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Quadriplegia

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https://www.readbyqxmd.com/read/27920716/acute-clinical-worsening-after-steroid-administration-in-cervical-myelitis-may-reveal-a-subdural-arteriovenous-fistula
#1
Silvia Rain, Jan Udding, Daniel Broere
Subdural arteriovenous fistula (SDAVF) is a rare condition characterized by clinical manifestations ranging from mild bilateral sensory deficits to quadriplegia. The diagnosis is often delayed due to unspecific neurological symptoms, initially diagnosed as polyneuropathy or myelopathy. The diagnosis can be delayed for as long as 1-15 years. The following report describes a cervical SDAVF case initially misdiagnosed as myelitis transversa and treated with intravenous steroids. A 56-year-old male presented with sensory deficits and mild leg and right arm weakness...
September 2016: Case Reports in Neurology
https://www.readbyqxmd.com/read/27909638/four-rod-instrumentation-for-treatment-of-charcot-spinal-arthropathy-causing-autonomic-dysreflexia-case-report-and-literature-review
#2
Stephanie Zyck, Gentian Toshkezi, John Pizzuti, Satya Marawar
Late complications of spinal cord injury can include Charcot arthropathy, in which spinal instability occurs as a result of repetitive trauma in the insensate spine. In rare cases, this can present as autonomic dysreflexia. We present the case of a 60-year-old man with longstanding C6 quadriplegia who presented with six months of hypertension, diaphoresis and dizziness. After an extensive workup, the patient's symptoms were attributed to autonomic dysreflexia in the setting of spinal instability from Charcot spinal arthropathy...
October 27, 2016: Curēus
https://www.readbyqxmd.com/read/27871959/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#3
REVIEW
Lucie Chochina, Florian Naudet, Clément Chéhensse, Andrea Manunta, Mireille Damphousse, Isabelle Bonan, François Giuliano
INTRODUCTION: Despite improvements in the care of patients after spinal cord injury (SCI), permanent impairment of locomotion, sensation, and autonomic function remains a major hurdle. After the acute stage of injury, recovering sexual function is a high priority. AIM: To review the efficacy of intracavernous injections (ICIs) in men with SCI and to identify prognostic factors affecting the efficacy of ICIs in this population. METHODS: Systematic review of the literature was conducted using the PubMed-Medline, Embase, EBSCO, Web of Science, and Cochrane Library databases...
July 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27801768/severe-relapse-after-cessation-of-immunosuppressive-therapy-in-a-patient-with-neuromyelitis-optica-spectrum-disorder
#4
Jae-Won Hyun, Gayoung Kim, Yeseul Kim, In Hye Jeong, Su-Hyun Kim, Ho Jin Kim
INTRODUCTION: The optimal duration of immunosuppressive therapy (IT) for neuromyelitis optica spectrum disorder (NMOSD) has not been established. Here, we report a case of severe relapse after early cessation of IT. CASE REPORT: A 32-year-old woman presented with a 2-week history of intractable vomiting and hiccups followed by quadriplegia with respiratory insufficiency. Spinal cord MRI showed longitudinally extensive transverse myelitis (LETM) and aquaporin-4-immunoglobulin-G (AQP4-IgG) was positive...
November 2016: Neurologist
https://www.readbyqxmd.com/read/27797801/weston-hurst-syndrome-a-rare-fulminant-form-of-acute-disseminated-encephalomyelitis-adem
#5
Sumaira Nabi, Mazhar Badshah, Shahzad Ahmed, Ali Zohair Nomani
A 25-year-old Pakistani woman presented to the emergency department with a 2-day history of rapidly progressive tetraplegia followed by sudden loss of consciousness. This was preceded by an upper respiratory tract infection. On examination, she was deeply comatose with a GCS of 3/15 and intact brainstem reflexes. She was in respiratory distress, and an endotracheal tube had been passed. She had flaccid quadriplegia with depressed deep tendon reflexes and upgoing plantar response. Her MRI brain with contrast showed extensive brainstem involvement with haemorrhagic foci along with signal changes in the corpus callosum...
October 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27766904/intraspinal-hypotension-syndrome-presents-as-transient-quadriplegia
#6
Miki Katzir, Svetlana Tov, Ayelet Eran, Gill E Sviri
Intracranial hypotension can be a complication of epidural anaesthesia. Pure clinical spinal hypotension manifesting as acute transient quadriplegia following epidural anaesthesia is a severe, life-threatening complication that have not been described before. This complication can be solved with an epidural blood patch; thus, it should be familiar to doctors across all specialities.
October 21, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27762171/decrease-of-spasticity-after-hybrid-assistive-limb-%C3%A2-training-for-a-patient-with-c4-quadriplegia-due-to-chronic-sci
#7
Akira Ikumi, Shigeki Kubota, Yukiyo Shimizu, Hideki Kadone, Aiki Marushima, Tomoyuki Ueno, Hiroaki Kawamoto, Yasushi Hada, Akira Matsumura, Yoshiyuki Sankai, Masashi Yamazaki
CONTEXT: Recently, locomotor training with robotic assistance has been found effective in treating spinal cord injury (SCI). Our case report examined locomotor training using the robotic suit hybrid assistive limb (HAL) in a patient with complete C4 quadriplegia due to chronic SCI. This is the first report examining HAL in complete C4 quadriplegia. FINDINGS: The patient was a 19-year-old man who dislocated C3/4 during judo 4 years previously. Following the injury, he underwent C3/4 posterior spinal fusion but remained paralyzed despite rehabilitation...
October 20, 2016: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/27743885/the-first-report-of-japanese-patients-with-asparagine-synthetase-deficiency
#8
Takahiro Yamamoto, Wakaba Endo, Hidenori Ohnishi, Kazuo Kubota, Norio Kawamoto, Takehiko Inui, Atsushi Imamura, Jun-Ichi Takanashi, Masaaki Shiina, Hirotomo Saitsu, Kazuhiro Ogata, Naomichi Matsumoto, Kazuhiro Haginoya, Toshiyuki Fukao
BACKGROUND: Asparagine synthetase (ASNS) deficiency was recently discovered as a metabolic disorder of non-essential amino acids, and presents as severe progressive microcephaly, intellectual disorder, dyskinetic quadriplegia, and intractable seizures. METHODS: Two Japanese children with progressive microcephaly born to unrelated patients were analyzed by whole exome sequencing and novel ASNS mutations were identified. The effects of the ASNS mutations were analyzed by structural evaluation and in silico predictions...
October 12, 2016: Brain & Development
https://www.readbyqxmd.com/read/27705010/therapeutic-effects-of-intensive-voice-treatment-lsvt-loud-for-children-with-spastic-cerebral-palsy-and-dysarthria-a-phase-i-treatment-validation-study
#9
Carol A Boliek, Cynthia M Fox
PURPOSE: The aim of the present study was to validate and extend the evaluation of treatment outcomes following LSVT LOUD® in children with dysarthria secondary to cerebral palsy (CP). METHOD: Seven children (5 females, 6-10 years) with spastic quadriplegia and dysarthria received LSVT LOUD. Outcomes included: (a) quantitative and qualitative indices of communication and social functioning representing therapeutic effects and (b) features of the acoustic signal representing physiological effects on the speech mechanism...
October 5, 2016: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/27692425/orthodontic-treatment-and-follow-up-of-a-patient-with-cerebral-palsy-and-spastic-quadriplegia
#10
Muhsin Çifter, Nil Cura
INTRODUCTION: This report describes the clinical orthodontic management of a patient with spastic quadriplegia and cerebral palsy. Guidelines to overcome difficulties encountered during the treatment period are suggested. METHODS: A 13-year-old boy with cerebral palsy and spastic quadriplegia complained of an undesirable oral appearance because of his malocclusion. He had a Class II molar relationship, with severe maxillary and moderate mandibular anterior crowding...
October 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27679535/predominant-corticospinal-tract-involvement-in-a-late-infant-with-krabbe-disease
#11
Ayumi Yoshimura, Tetsuya Kibe, Kaori Irahara, Norio Sakai, Kenji Yokochi
A case of late-infantile Krabbe disease in a patient who presented with developmental regression and spastic quadriplegia in late infancy is reported. Brain magnetic resonance imaging (MRI) at 11 months of age showed predominant corticospinal tract involvement, which usually appears in adult Krabbe disease. Galactocerebrosidase activity in lymphocytes and skin fibroblasts was very low. Genetic testing revealed compound heterozygous mutations of the galactocerebrosidase (GALC) gene, c.635_646 delinsCTC and c...
2016: Japanese Clinical Medicine
https://www.readbyqxmd.com/read/27677045/management-in-a-rehabilitation-department-in-pott-s-disease
#12
Emna Toulgui, Sonia Jemni, Samia Frioui, Nadia Lazreg, Sahbi Mtaouaa, Fayçal Khachnaoui
OBJECTIVE: Tuberculous spondylitis, or Pott's disease, is a public health problem in Tunisia, where it occurs as an endemic disease. It is the most common and most severe articular bone tuberculosis. It is responsible for a major handicap because of its location and its destructive nature. This work aims to assess the contribution of rehabilitation for patients with Pott's disease. MATERIAL/PATIENTS AND METHODS: A retrospective study that included 29 patients with Pott's disease and hospitalized in PMR Service...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27676717/intracavernous-injections-in-spinal-cord-injured-men-with-erectile-dysfunction-a-systematic-review-and-meta-analysis
#13
Lucie Chochina, Florian Naudet, Isabelle Bonan, Clément Chehensse, Mireille Damphousse, Andrea Manunta, François Giuliano
OBJECTIVE: To review the efficacy of intracavernous injections (ICI) in spinal cord injured (SCI) men and to identify prognostic factors affecting the efficacy of ICI in this population. MATERIAL/PATIENTS AND METHODS: Systematic review of the literature using 5 databases. Articles published up to november 2014 using the keywords: alprostadil; papaverine; moxisylyte; alpha-blocking agent; phentolamine; intracavernous injection; spinal cord injuries; paraplegia; quadriplegia; erectile dysfunction; were included...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27673216/poster-472-8-year-old-male-with-flaccid-quadriplegia-after-bone-marrow-transplant-a-case-report
#14
Mariella Hillebrand, Suzanne L Woodbury
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27671278/incidental-occlusion-of-anterior-spinal-artery-due-to-onyx-reflux-in-embolization-of-spinal-type-ii-arteriovenous-malformation
#15
Joohyun Kim, Jang-Bo Lee, Tai-Hyoung Cho, Junseok W Hur
PURPOSE: Onyx embolization is one of the standard treatments for brain arteriovenous malformations (AVMs) and is a promising method for spinal AVMs as well. Its advantages have been emphasized, and few complications have been reported with Onyx embolization in spinal AVMs. Here, we report an incidental anterior spinal artery (ASA) occlusion due to Onyx reflux during embolization of a spinal type II AVM. METHODS: A 15-year-old boy presented with weakness in both upper and lower extremities...
September 26, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27669485/guillain-barr%C3%A3-syndrome-and-cerebral-hemorrhage-two-cases-and-literature-review
#16
Qian Wu, Na Liu, Chao Pan, Bitao Bu, Zhouping Tang
AIMS: The study aimed to investigate the potential relationships between Guillain-Barré syndrome (GBS) and cerebral hemorrhage. METHODS: Two patients diagnosed with hemorrhagic stroke and GBS were reported. More specifically, the sequential occurrence and the corresponding mechanisms of these 2 diseases were analyzed. RESULTS: Two patients with cerebral hemorrhagic stroke developed progressive flaccid quadriplegia and life-threatening dyspnea in acute stage...
2016: European Neurology
https://www.readbyqxmd.com/read/27666370/biallelic-mutations-in-tbcd-encoding-the-tubulin-folding-cofactor-d-perturb-microtubule-dynamics-and-cause-early-onset-encephalopathy
#17
Elisabetta Flex, Marcello Niceta, Serena Cecchetti, Isabelle Thiffault, Margaret G Au, Alessandro Capuano, Emanuela Piermarini, Anna A Ivanova, Joshua W Francis, Giovanni Chillemi, Balasubramanian Chandramouli, Giovanna Carpentieri, Charlotte A Haaxma, Andrea Ciolfi, Simone Pizzi, Ganka V Douglas, Kara Levine, Antonella Sferra, Maria Lisa Dentici, Rolph R Pfundt, Jean-Baptiste Le Pichon, Emily Farrow, Frank Baas, Fiorella Piemonte, Bruno Dallapiccola, John M Graham, Carol J Saunders, Enrico Bertini, Richard A Kahn, David A Koolen, Marco Tartaglia
Microtubules are dynamic cytoskeletal elements coordinating and supporting a variety of neuronal processes, including cell division, migration, polarity, intracellular trafficking, and signal transduction. Mutations in genes encoding tubulins and microtubule-associated proteins are known to cause neurodevelopmental and neurodegenerative disorders. Growing evidence suggests that altered microtubule dynamics may also underlie or contribute to neurodevelopmental disorders and neurodegeneration. We report that biallelic mutations in TBCD, encoding one of the five co-chaperones required for assembly and disassembly of the αβ-tubulin heterodimer, the structural unit of microtubules, cause a disease with neurodevelopmental and neurodegenerative features characterized by early-onset cortical atrophy, secondary hypomyelination, microcephaly, thin corpus callosum, developmental delay, intellectual disability, seizures, optic atrophy, and spastic quadriplegia...
October 6, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27658585/using-an-artificial-neural-bypass-to-restore-cortical-control-of-rhythmic-movements-in-a-human-with-quadriplegia
#18
Gaurav Sharma, David A Friedenberg, Nicholas Annetta, Bradley Glenn, Marcie Bockbrader, Connor Majstorovic, Stephanie Domas, W Jerry Mysiw, Ali Rezai, Chad Bouton
Neuroprosthetic technology has been used to restore cortical control of discrete (non-rhythmic) hand movements in a paralyzed person. However, cortical control of rhythmic movements which originate in the brain but are coordinated by Central Pattern Generator (CPG) neural networks in the spinal cord has not been demonstrated previously. Here we show a demonstration of an artificial neural bypass technology that decodes cortical activity and emulates spinal cord CPG function allowing volitional rhythmic hand movement...
September 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27651339/acute-traumatic-quadriplegia-in-adults-predictors-of-acute-in-hospital-mortality
#19
Khalid Alsaleh, Drew Bednar, Forough Farrokhyar
AIM: To assess the in-hospital mortality in adult patients suffering acute traumatic complete quadriplegia and determine the possible predictors of mortality in these patients. MATERIAL AND METHODS: A retrospective review of adult traumatic complete quadriplegia cases treated at our spine injuries unit from 1996 to 2004 was undertaken in the attempt to define risk factors for acute and subacute (within 3 months of injury) in-hospital mortality Results: We identified 126 cases of cervical SCI treated at our hospital from January 1996 to March 2004 and identified only 62 cases of complete quadriplegia...
May 5, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27641254/microsurgical-resection-of-cervical-spinal-cord-arteriovenous-malformations-report-of-six-cases
#20
Zhuo-Peng Ye, Xiao-Yan Yang, Wen-Shen Li, Bo Hou, Ying Guo
OBJECTIVE: This study aims to summarize the experience of microsurgical resection of cervical spinal cord arteriovenous malformation (AVM). METHODS: Six cases receiving microsurgical resection of cervical intramedullary AVMs in the Third Affiliated Hospital of Sun Yat-sen University, China, from March 2005 to 2015, were retrospectively reviewed, and their clinical manifestations, imaging examination, surgical treatment, and results of long-term follow-up were analyzed...
September 15, 2016: World Neurosurgery
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