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https://www.readbyqxmd.com/read/29341504/a-multi-institutional-analysis-of-children-on-long-term-non-invasive-respiratory-support-and-their-outcomes
#1
Monica L Koncicki, Philip Zachariah, Adam R Lucas, Jeffrey D Edwards
OBJECTIVES: To characterize a multi-institutional cohort of children with chronic respiratory failure that use long-term, non-invasive respiratory support, perform a time-to-event analysis of transitions to transtracheal ventilation and identify factors associated with earlier transition to transtracheal ventilation. STUDY DESIGN: A retrospective cohort study of patients less than 21 years of age with diagnoses associated with chronic respiratory failure and discharged on non-invasive respiratory support was performed using data from the Pediatric Health Information System (PHIS) between 2007 and 2015...
January 17, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29250451/hypokalemic-paralysis-secondary-to-immune-checkpoint-inhibitor-therapy
#2
Pragathi Balakrishna, Augusto Villegas
Introduction of immune checkpoint inhibitors (ICIs) has led to significant improvements in the treatment of multiple malignancies. Anti-programmed cell death protein 1 (PD-1) and anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) are two essential ICIs that have been FDA approved since 2011. As the use of immunotherapy in melanoma and other malignancies increases, the potential of adverse events also increases. Overall, anti-PD-1 agents are well tolerated. In rare instances, colitis, endocrinopathies, skin, and renal toxicities have been observed...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29245289/perioperative-management-of-a-patient-with-coffin-lowry-syndrome-complicated-by-severe-obesity-a-case-report-and-literature-review
#3
Mikako Hirakawa, Tasuku Nishihara, Kazuo Nakanishi, Sakiko Kitamura, Sonoko Fujii, Keizo Ikemune, Kentaro Dote, Yasushi Takasaki, Toshihiro Yorozuya
RATIONALE: Coffin-Lowry syndrome (CLS) is a rare inherited disease with specific clinical features, such as mental retardation, facial dysmorphism, and cardiac abnormality. In particular, the characteristic facial features of CLS, including retrognathia and large tongue, are associated with difficult ventilation and/or intubation, which is a serious problem of anesthesia management. However, case reports on anesthesia management of CLS are very limited as there are only two published English reports till date...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245281/spontaneous-spinal-epidural-hematoma-mimicking-transient-ischemic-attack-a-case-report
#4
Chuqiao Li, Rui He, Xiaoqiang Li, Yulan Zhong, Li Ling, Fangming Li
RATIONALE: Spontaneous spinal epidural hematoma (SSEH) is a rare but highly disabling neurological emergency. The initial presentations are variable. Most patients of SSEH present with paraplegia or tetraplegia clinically, but recurrent hemiparesis with complete spontaneous recovery, mimicking transient ischemic attack (TIA), is a very rare initial presentation of SSEH. PATIENT CONCERNS: A 71-year-old female presented to the emergency department with 2 episodes of transient right hemiparesis in 5 hours...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29245227/spinal-intramedullary-tuberculoma-following-pulmonary-tuberculosis-a-case-report-and-literature-review
#5
Guan-Chyuan Wang, Sheng-Wen Wu
RATIONALE: Spinal intramedullary tuberculoma (IMTB) is a rare disease that accounts for 1 to 2/100,000 patients with tuberculosis. We presented a case with pulmonary tuberculosis and concurrent IMTB at C3 to C5 level and reviewed the recent case series and discussed the diagnosis, treatment, and outcome. PATIENT CONCERNS: A 33-year-old male had concurrent pulmonary TB and IMTB at the C3 to C5 level. He had quadriplegia (muscle power 0 at 4 limbs) and sensory loss below C5 level...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29237660/disseminated-coccidioidomycosis-related-cervical-intramedullary-lesion-causing-quadriplegia-in-an-immunocompetent-host
#6
James Michael Noto, Raquel Nahra, Tapan Kavi
No abstract text is available yet for this article.
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29209163/voluntary-ambulation-by-upper-limb-triggered-hal%C3%A2-in-patients-with-complete-quadri-paraplegia-due-to-chronic-spinal-cord-injury
#7
Yukiyo Shimizu, Hideki Kadone, Shigeki Kubota, Kenji Suzuki, Tetsuya Abe, Tomoyuki Ueno, Yuichiro Soma, Yoshiyuki Sankai, Yasushi Hada, Masashi Yamazaki
Patients with complete paraplegia after spinal cord injury (SCI) are unable to stand or walk on their own. Standing exercise decreases the risk of decubitus ulcers, osteoporosis, and joint deformities in patients with SCI. Conventional gait training for complete paraplegia requires excessive upper limb usage for weight bearing and is difficult in cases of complete quadriplegia. The purpose of this study was to describe voluntary ambulation triggered by upper limb activity using the Hybrid Assistive Limb® (HAL) in patients with complete quadri/paraplegia after chronic SCI...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29176492/the-weight-bearing-shoulder
#8
Ronak M Patel, Jonathan D Gelber, Mark S Schickendantz
The shoulder achieves a wide spectrum of motion, and in a subset of patients, including those who use manual wheelchairs and upper extremity walking aids, the shoulder also serves as the primary weight-bearing joint. Because the weight-bearing shoulder is subject to considerable joint reaction forces and overuse, a broad spectrum of pathology can affect the joint. The combination of muscle imbalance and repetitive trauma presents most commonly as subacromial impingement syndrome but can progress to other pathology...
November 20, 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29123343/multiple-nutritional-deficiencies-in-cerebral-palsy-compounding-physical-and-functional-impairments
#9
P G Hariprasad, K E Elizabeth, Mathew J Valamparampil, D Kalpana, T S Anish
Introduction: Cerebral palsy (CP) refers to a spectrum of disorders causing physical and intellectual morbidity. Macro and micro nutrient deficiencies often contribute to the subnormal physical and mental capabilities of them. Objectives: To assess the growth, nutritional status, physical and functional ability and quality of life in cerebral palsy children and to determine any relation with their gross motor and functional capabilities. Method: The study was conducted at a Tertiary Care Centre, with the participants in the age group 1-16 years...
October 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29117788/recurrent-admissions-for-hypothermia-from-concomitant-topiramate-and-phenobarbital-a-case-report
#10
Alisha M Mutch
INTRODUCTION: This article presents an additional case of concomitant topiramate and phenobarbital administration that resulted in 8 hospital admissions for hypothermia that resolved after discontinuation of phenobarbital. CASE: A 56-year-old white female with cerebral palsy and quadriplegia, epilepsy, and hypothyroidism was admitted to a community teaching hospital multiple times with documented hypothermia. These admissions followed a subsequent dose increase of topiramate in December 2014...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29116382/selective-dorsal-rhizotomy-for-the-treatment-of-severe-spastic-cerebral-palsy-efficacy-and-therapeutic-durability-in-gmfcs-grade-iv-and-v-children
#11
Daniel D'Aquino, Ahmad A Moussa, Amr Ammar, Harshal Ingale, Michael Vloeberghs
BACKGROUND: Selective dorsal rhizotomy (SDR) has been established as an effective surgical treatment for spastic diplegia. The applicability of SDR to the full spectrum of spastic cerebral palsy and the durability of its therapeutic effects remain under investigation. There are currently limited data in the literature regarding efficacy and outcomes following SDR in Gross Motor Function Classification System (GMFCS) IV and V patients. Intrathecal baclofen has traditionally been the surgical treatment of choice for these patients...
November 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29082563/magnetic-resonance-imaging-of-the-upper-airway-in-patients-with-quadriplegia-and-obstructive-sleep-apnea
#12
Fergal J O'donoghue, Hailey Meaklim, Lynne Bilston, Alice Hatt, Alan Connelly, Graeme Jackson, Shawna Farquharson, Kate Sutherland, Peter A Cistulli, Douglas J Brown, David J Berlowitz
The aim of this study was to investigate upper airway anatomy in quadriplegics with obstructive sleep apnea. Fifty subjects were recruited from three hospitals in Australia: people with quadriplegia due to spinal cord injury and obstructive sleep apnea (n = 11), able-bodied people with obstructive sleep apnea (n = 18), and healthy, able-bodied controls (n = 19). All underwent 3-Tesla magnetic resonance imaging of their upper airway. A subgroup (n = 34) received a topical vasoconstrictor, phenylephrine and post-phenylephrine magnetic resonance imaging...
October 30, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29074369/transient-hypokalemic-quadriplegia-following-a-lumbar-transforaminal-epidural-dexamethasone-injection-a-case-report
#13
Maryam Tahmasbi Sohi, William J Sullivan, Dustin J M Anderson
A 30-year-old male with no significant past medical history presented with hypokalemic quadriplegia four hours after he received a lumbar transforaminal epidural steroid injection (TFESI) containing dexamethasone and lidocaine. A comprehensive work up ruled out acquired and hereditary causes of hypokalemic paralysis. Symptoms gradually resolved within hours after potassium restoration with no residual neurologic deficits. Paralysis after TFESI is uncommon, but has been associated with particulate steroids that can coalesce into aggregates and occlude vessels...
October 23, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29021885/fracture-dislocation-at-c6-c7-level-with-quadriplegia-after-traditional-massage-in-a-patient-with-ankylosing-spondylitis-a-case-report
#14
Kak Abilash, Qmq Mohd, Zah Ahmad, Basir Towil
Ankylosing spinal disorders (ASD) tend to result in fractures and/or dislocations after minor trauma because of the altered biomechanical properties. The relative risk of traumatic vertebral fractures in patients with ankylosing spondylitis has been estimated as three times higher than in the general population. These spine traumas, which are located at cervical level in 81% of patients with ankylosing spondylitis, are complicated by neurological lesions in 65% of patients, due to the high inherent instability of these fractures...
July 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29020869/a-review-of-four-health-procedures-that-school-nurses-may-encounter
#15
Rebecca Toothaker, Pamela Cook
The school nurse plays a vital role in providing care and meeting the health needs of students in the school setting. Students attend school with chronic conditions and complex medical problems such as quadriplegia, cerebral palsy, spina bifida, and muscular dystrophy. It is the responsibility of the school nurse to provide appropriate assessment, early intervention, and care for children in the school environment. The purpose of this article is to review and discuss the knowledge and skills the school nurse needs to care for students with central venous lines, gastrostomy tubes, altered urinary elimination, and tracheostomies...
October 1, 2017: NASN School Nurse
https://www.readbyqxmd.com/read/29017982/clinical-presentation-diagnosis-and-surgical-treatment-of-spontaneous-cervical-intradural-disc-herniations-a-review-of-the-literature
#16
REVIEW
Arunprasad Gunasekaran, Nova Kristine M de Los Reyes, Jerry Walters, Noojan Kazemi
OBJECTIVE: Spontaneous cervical intradural disc herniation (IDH) is a rare occurrence with limited and disparate information available regarding its presentation, diagnosis, and treatment. However, its accurate detection is vital for planning surgical treatment. In this review of the literature, we collected data from all cervical intradural disc herniations described to date. Particular attention is paid to diagnostic findings, surgical approach and causation for cervical IDH, especially at the cervicothoracic junction...
October 7, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28990647/-medullar-thoracic-compression-by-tophaceous-gout-presentation-of-a-case-and-review-of-the-literature
#17
(no author information available yet)
INTRODUCTION: Spine involvement in gout is an extremely uncommon complication. Dorsalgia and quadriplegia are some manifestations that may occur, although these symptoms are seen more frequently in other more prevalent pathologies, such as spinal tumors. CASE REPORT: We present an unusual case of thoracic spinal cord compression at T10-T11 level caused by the extradural deposit of tophaceous material in a 52-year-old woman with uncontrolled chronic tophaceous gout...
October 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28983951/development-of-a-cerebral-palsy-follow-up-registry-in-jordan-cpup-jordan
#18
N A Almasri, M Saleh, S Abu-Dahab, S H Malkawi, E Nordmark
AIMS: This study aims to describe the development of a Cerebral Palsy Follow-up Registry in Jordan (CPUP-Jordan) and to provide a baseline child and parent demographic information, birth history of the child participants, and distribution of the participants based on topographical distribution of cerebral palsy (CP) and functional classification systems. METHODS: The CPUP-Jordan was developed using a similar framework of a follow-up surveillance programme for persons with CP in Sweden (CPUP)...
October 6, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28973395/tubb4a-mutations-result-in-specific-neuronal-and-oligodendrocytic-defects-that-closely-match-clinically-distinct-phenotypes
#19
Julian Curiel, Guillermo Rodríguez Bey, Asako Takanohashi, Marianna Bugiani, Xiaoqin Fu, Nicole I Wolf, Bruce Nmezi, Raphael Schiffmann, Mona Bugaighis, Tyler Pierson, Guy Helman, Cas Simons, Marjo S van der Knaap, Judy Liu, Quasar Padiath, Adeline Vanderver
Hypomyelinating leukodystrophies are heritable disorders defined by lack of development of brain myelin, but the cellular mechanisms of hypomyelination are often poorly understood. Mutations in TUBB4A, encoding the tubulin isoform tubulin beta class IVA (Tubb4a), result in the symptom complex of hypomyelination with atrophy of basal ganglia and cerebellum (H-ABC). Additionally, TUBB4A mutations are known to result in a broad phenotypic spectrum, ranging from primary dystonia (DYT4), isolated hypomyelination with spastic quadriplegia, and an infantile onset encephalopathy, suggesting multiple cell types may be involved...
November 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28953517/acute-onset-quadriplegia-with-recovery-after-high-voltage-electrical-injury
#20
Daniel Delgadillo, Stephanie Chapman, Matthew P Fahrenkopf, Matthew D Martin
Although uncommon, electrical injuries are associated with significant morbidity and mortality. There have been several reports of neurological sequelae secondary to electrical injury; however, the neurophysiology is still not completely understood. These neurological complications pose the greatest risk for permanent disability. We present a case of acute-onset quadriplegia after high-voltage electrical injury without radiographic evidence. Two months after the injury, the patient went on to regain partial sensorimotor function...
November 2017: Annals of Plastic Surgery
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