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https://www.readbyqxmd.com/read/29346671/hematological-analysis-in-thai-samples-with-deletional-and-nondeletional-hbh-diseases
#1
Sakorn Pornprasert, Nur-Afsan Salaeh, Monthathip Tookjai, Manoo Punyamung, Panida Pongpunyayuen, Kallayanee Treesuwan
Objectives: To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods: Samples of 43 deletional HbH diseases, which included 39 --SEA/-α3.7, 4 - -SEA/-α4.2, and 22 nondeletional HbH diseases (- -SEA/αcsα), were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed...
January 13, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29343036/-analysis-of-genotype-and-hematological-phenotype-of-14-patients-with-coinheritance-hk%C3%AE-%C3%AE-and-south-east-deletion-thalassemia
#2
L Y Zhong, F Wang, P S Chen, Y J Xie, J Y Tan, M Liu, B Huang, W B Lin
Objective: To analyze the genotype-phenotype correlations among those thalassemia samples with the presence of -α(3.7,) --(SEA) and normal α(2) alleles on their α-globin gene clusters. Methods: Fourteen patients(including 1fetus, 4 males and 9 females, aged 0- 56 years old)who were suspected diagnosed by hematologic analysis and genetic testing among 16 080 participants in our laboratory since from August 2011 to August 2016, were enrolled. Complete blood cell count was performed on XE4000i automatic hemocyte analyzer...
January 9, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29340128/hematological-reference-intervals-for-healthy-iranian-blood-donors
#3
Mahboubeh Rasouli, Mojgan Pourmokhtar, Shaghayegh Sarkardeh
Background: Development of locally-derived hematological reference intervals is necessary for improving the quality of health care and clinical trials. However hematological reference intervals are affected by several variables including age, gender and environmental factors. Therefore this study was conducted to determine the gender and age-specific hematological reference intervals of healthy Iranian blood donors. Materials and Methods: Selected hematological indices of 394 healthy blood donor volunteers, donating blood at Tehran Blood Transfusion Center were analyzed...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29338568/lactoferrin-plus-health-education-versus-total-dose-infusion-tdi-of-low-molecular-weight-lmw-iron-dextran-for-treating-iron-deficiency-anemia-ida-in-pregnancy-a-randomized-controlled-trial
#4
A M Darwish, Fouly Ha, W H Saied, E Farah
BACKGROUND: Iron deficiency anemia (IDA) is one of the most common medical disorder disturbing pregnancies particularly in low resources countries, and contributes significantly to morbidities and mortalities. Thus, early diagnosis and prompt management of IDA is highly recommended. AIM: To Test the efficacy and safety of oral lactoferrin plus health education provided by a nurse versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating IDA in the second and third trimester of pregnancy...
January 16, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29335480/novel-analgesic-effects-of-melanin-concentrating-hormone-on-persistent-neuropathic-and-inflammatory-pain-in-mice
#5
Jae-Hwan Jang, Ji-Yeun Park, Ju-Young Oh, Sun-Jeong Bae, Hyunchul Jang, Songhee Jeon, Jongpil Kim, Hi-Joon Park
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons in the lateral hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, indicating the involvements of many physiological functions, but the role in pain has yet to be determined. In this study, we found that pMCH-/- mice showed lower baseline pain thresholds to mechanical and thermal stimuli than did pMCH+/+ mice, and the time to reach the maximum hyperalgesic response was also significantly earlier in both inflammatory and neuropathic pain...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331737/hematology-reference-intervals-for-neonatal-holstein-calves
#6
Nikolaos Panousis, Nektarios Siachos, Georgios Kitkas, Emmanouil Kalaitzakis, Maria Kritsepi-Konstantinou, Georgios E Valergakis
Data regarding hematologic reference intervals (RI) for neonatal calves have not been published yet. The aims of this study were: a) to establish hematology RIs for neonatal Holstein calves, b) to compare them with the RIs for lactating cows, and c) to investigate the relationship of age and gender with the hematologic profile of calves. Two-hundred and fifty-four clinically healthy Holstein calves (1-9days old, from 30 farms) and 82 healthy Holstein cows (between 30 and 150days in milk, from 10 farms) were blood sampled once for a complete blood count evaluation, using the ADVIA 120 hematology analyzer...
January 9, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29327348/respiratory-dysfunction-progresses-with-age-in-kcna1-null-mice-a-model-of-sudden-unexpected-death-in-epilepsy
#7
Kristina A Simeone, Jodi Hallgren, Charles S Bockman, Ankita Aggarwal, Vikash Kansal, Lauren Netzel, Shruthi H Iyer, Stephanie A Matthews, Malavika Deodhar, Peter J Oldenburg, Peter W Abel, Timothy A Simeone
OBJECTIVE: Increased breathing rate, apnea, and respiratory failure are associated with sudden unexpected death in epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kcna1-/- mice, a model of temporal lobe epilepsy and SUDEP. Here we tested the hypothesis that respiratory dysfunction progresses with age in Kcna1-/- mice, thereby increasing risk of respiratory failure and sudden death (SD). METHODS: Respiratory parameters were determined in conscious mice at baseline and following increasing doses of methacholine (MCh) using noninvasive airway mechanics (NAM) systems...
January 12, 2018: Epilepsia
https://www.readbyqxmd.com/read/29325171/maternal-and-child-health-handbook-use-for-maternal-and-child-care-a-cluster-randomized-controlled-study-in-rural-java-indonesia
#8
Keiko Osaki, Tomoko Hattori, Akemi Toda, Erna Mulati, Lukas Hermawan, Kirana Pritasari, Saptawati Bardosono, Soewarta Kosen
Background: Effectiveness of the Maternal and Child Health Handbook (MCHHB), a home-based booklet for pregnancy, delivery and postnatal/child health, was evaluated on care acquisition and home care in rural Java, a low service-coverage area. Methods: We conducted a health centre-based randomized trial, with a 2-year follow-up. Intervention included (i) MCHHB provision at antenatal care visits; (ii) records and guides by health personnel on and with the MCHHB; and (iii) sensitization of care by volunteers using the MCHHB...
January 9, 2018: Journal of Public Health
https://www.readbyqxmd.com/read/29323189/il-13-in-lps-induced-inflammation-causes-bcl-2-expression-to-sustain-hyperplastic-mucous-cells
#9
Hitendra S Chand, Jennifer F Harris, Yohannes Tesfaigzi
Exposure to lipopolysaccharides (LPS) causes extensive neutrophilic inflammation in the airways followed by mucous cell hyperplasia (MCH) that is sustained by the anti-apoptotic protein, Bcl-2. To identify inflammatory factor(s) that are responsible for Bcl-2 expression, we established an organ culture system consisting of airway epithelial tissue from the rat nasal midseptum. The highest Muc5AC and Bcl-2 expression was observed when organ cultures were treated with brochoalveolar lavage (BAL) fluid harvested from rats 10 h post LPS instillation...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321527/a-hospital-based-retrospective-study-of-factors-influencing-therapeutic-leukapheresis-in-patients-presenting-with-hyperleukocytic-leukaemia
#10
Yanxia Jin, Shishang Guo, Qin Cui, Sichao Chen, Xiaoping Liu, Yongchang Wei, Yunbao Pan, Liang Tang, Tingting Huang, Hui Shen, Guanghui Xu, Xuelan Zuo, Shangqin Liu, Hui Xiao, Fei Chen, Fayun Gong, Fuling Zhou
Therapeutic leukapheresis is a rapid and effective method to reduce early mortality of patients with hyperleukocytic leukaemia (HLL). However, few studies on factors influencing the efficiency have been reported. In this study, 67 cases who underwent leukapheresis were retrospectively analysed and factors related to the collection efficiency of leukapheresis (CEWBC) were also evaluated. Paired t test showed that there was a significant decrease in statistics of white blood cell (WBC) counts after apheresis...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314865/il-17-plays-a-role-in-rsv-induced-lung-inflammation-and-emphysema-in-elastase-and-lps-injured-mice
#11
Yohannes A Mebratu, Yohannes Tesfaigzi
Respiratory syncytial virus (RSV) is associated with enhanced progression of chronic obstructive pulmonary disease (COPD) and COPD exacerbations. However, little is known about the role of IL-17 in RSV-induced lung injury. We first investigated the role of RSV infection in enhancing mucous cell hyperplasia and airspace enlargement in the lungs of mice injured with elastase and lipopolysaccharide (E/LPS). Mice injured with E/LPS had an enhanced and prolonged neutrophilic response to RSV that was associated with decreased levels of type I IFN and increased levels of IL-17, IL-23, CXCL-1, GCSF and CXCL-5 and MMP-9...
January 9, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29310654/pattern-and-determinants-of-contraceptive-usage-among-women-of-reproductive-age-from-the-digo-community-residing-in-kwale-kenya-results-from-a-cross-sectional-household-survey
#12
Vernon Mochache, Amyn Lakhani, Hajara El-Busaidy, Marleen Temmerman, Peter Gichangi
BACKGROUND: Contraceptive usage has been associated with improved maternal and child health (MCH) outcomes. Despite significant resources being allocated to programs, there has been sub-optimal uptake of contraception, especially in the developing world. It is important therefore, to granulate factors that determine uptake and utilization of contraceptive services so as to inform effective programming. METHODS: Between March and December 2015, we conducted a cross-sectional survey among women of reproductive age (WRA) from the Digo community residing in Kwale County, Kenya...
January 8, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29308662/physiological-variations-among-blood-parameters-of-domestic-cats-at-high-and-low-altitude-regions-of-china
#13
Hui Zhang, Hailong Dong, Khalid Mehmood, Kun Li, Fazul Nabi, Zhenyu Chang, Mujeeb Ur Rehman, Muhammad Ijaz, Qingxia Wu, Jiakui Li
This study aims to determine the comparative haematological parameters and to check possible physiological changes among blood parameters of domestic cats living at high- and low-altitude regions of China. For this purpose, blood samples were randomly collected from healthy semi-long-haired Tonkinese cats in Tibet (high altitude) and Zhejiang (low altitude) regions of China. The results of present study showed that RBCs, HGB, MCH and MCHC values of Tibetan Tonkinese cats were significantly (p < .01) higher as compared to Zhejiang Tonkinese cats...
January 8, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29303771/short-and-medium-term-biological-variation-estimates-of-red-blood-cell-and-reticulocyte-parameters-in-healthy-subjects
#14
Sabrina Buoro, Anna Carobene, Michela Seghezzi, Barbara Manenti, Paola Dominoni, Aurelio Pacioni, Ferruccio Ceriotti, Cosimo Ottomano, Giuseppe Lippi
BACKGROUND: The integrated evaluation of traditional and innovative red blood cell (RBC) and reticulocyte parameters is a rapid, inexpensive and non-invasive diagnostic tools for differential diagnosis and follow-up of anemia and other pathological conditions needing bone marrow erythropoiesis assessment. Therefore, estimating the biological variation (BV) of these parameters is essential for evaluating the analytical performance of hematological analyzers, and for enabling accurate data interpretation and appropriate clinical management...
January 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29302863/innovations-in-maternal-and-child-health-pairing-undergraduate-and-graduate-maternal-and-child-health-students-in-summer-practica-in-state-title-v-agencies
#15
Arden Handler, Jaime Klaus, Deneen Long-White, Marcia Roth, Rebecca Greenleaf, Olivia R Sappenfield, Dorothy Cilenti
Objective As part of the National MCH Workforce Development Center, an innovative internship program placed MCH undergraduate and graduate students in summer practica in state Title V agencies. Graduate student mentoring of undergraduates and leadership and professional development training and support are key features of the program. The objective of this paper is to report on the results of the evaluation of the MCH Paired Practica Program in its pilot years, 2014-2016. Methods Students completed pre and post internship questionnaires which included closed as well as open-ended questions...
January 4, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29299793/bed-sharing-in-the-first-8-weeks-of-life-an-australian-study
#16
H M Cunningham, H Vally, L Bugeja
Background As the evidence continues to emerge about the relationship between sudden unexpected death in infancy (SUDI) and the way an infant sleeps, providing consistent and evidence-informed recommendations on how best to sleep infants is an ongoing challenge. A recent case series study in the state of Victoria, Australia, identified 45.8% of sleep-related infant deaths occurred whilst bed-sharing. This study prompted the need for further exploration of infant sleeping practices, including bed-sharing, in this population...
January 3, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29297135/stem-cell-factor-supports-migration-in-canine-mesenchymal-stem-cells
#17
Nathaly Enciso, Luciana L K Ostronoff, Guillermo Mejías, Leticia G León, María Luisa Fermín, Elena Merino, Cristina Fragio, Luis Avedillo, Concepción Tejero
Adult Mesenchymal Stem Cells (MSC) are cells that can be defined as multipotent cells able to differentiate into diverse lineages, under appropriate conditions. These cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Initially discovered in bone marrow, MSC can now be isolated from a wide spectrum of adult and foetal tissues. Studies to evaluate the therapeutic potential of these cells are based on their ability to arrive to damaged tissues. In this paper we have done a comparative study analyzing proliferation, surface markers and OCT4, SOX9, RUNX2, PPARG genes expression in MSC cells from Bone marrow (BMMSC) and Adipose tissue (ASC)...
January 3, 2018: Veterinary Research Communications
https://www.readbyqxmd.com/read/29294734/intimate-partner-violence-prevalence-recurrence-types-and-risk-factors-among-arab-and-jewish-immigrant-and-nonimmigrant-women-of-childbearing-age-in-israel
#18
Nihaya Daoud, Ruslan Sergienko, Ilana Shoham-Vardi
This research set out to determine prevalence, recurrence, types, and risk factors for intimate partner violence (IPV) among women of childrearing age across Israel, attending to diversity in these factors by ethnicity and immigration status. The first nationwide study of its kind, this research was based on a stratified proportional cluster sample of 1,401 Arab, and Jewish immigrant and nonimmigrant women (aged 16-48 years) who visited 63 maternal and child health (MCH) clinics between October 2014 and October 2015...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29287802/acute-and-sub-chronic-toxicological-studies-of-the-iridoid-glycosides-extract-of-lamiophlomis-rotata-benth-kudo-in-rats
#19
Quanlong Zhang, Zhujun Mao, Qiaoyan Zhang, Jianguo Qiu, Zhengping Jia, Luping Qin
Lamiophlomis rotata(Benth.) Kudo is widely used in traditional Chinese medicine and its iridoid glycosides extract (IGLR) was the main active ingredient with hemostatic, antinociceptive and anti-inflammatory effects. This study was aimed to evaluate the safety of IGLR using acute and sub-chronic toxicity study methods on Sprague-Dawley rats. In acute toxicity test, IGLR caused slight diarrhea in three dose groups and a decreased of RBC and increased of MCH and Ret (P < .05) were observed in 16 g/kg group...
December 26, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29260901/development-and-physicochemical-toxicity-and-immunogenicity-assessments-of-recombinant-hepatitis-b-surface-antigen-rhbsag-entrapped-in-chitosan-and-mannosylated-chitosan-nanoparticles-as-a-novel-vaccine-delivery-system-and-adjuvant
#20
Mohsen Mehrabi, Naser Mohammadpour Dounighi, Seyed Mahdi Rezayat Sorkhabadi, Delaram Doroud, Amir Amani, Mehdi Khoobi, Soheila Ajdary, Younes Pilehvar-Soltanahmadi
In this study chitosan nanoparticles (CS NPs) and mannosylated chitosan nanoparticles (MCH NPs) loaded with recombinant hepatitis B surface antigen (rHBsAg) was synthesized as a vaccine delivery system and assessed toxically and immunologically. The physicochemical properties of the nanoparticles (NPs) were determined by methods including scanning electron microscope (SEM) and dynamic light scattering (DLS). The morphology of the NPs was semi spherical and the average diameter of the loaded CS and MCH NPs was found to be 189 and 239 nm, respectively...
December 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
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