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https://www.readbyqxmd.com/read/29453018/-management-of-rhinosinusitis-in-primary-care
#1
N Gómez Gabaldón, C Manzanares Arnaiz, L Noguero Cánovas, J Juan Armas
Acute rhinosinusitis is an important health problem. Even though its frequency is not well documented in our country?, the economic burden it bears is not insignificant as it notably alters the quality of life of affected patients. Its diagnosis is generally clinical in nature, with further studies reserved only for the differential diagnoses of complications or tumour-like processes. The most frequent causes are viral infections, although Streptococcus pneumoniae and Haemophilus influenzae are the most commonly isolated bacterial agents...
February 13, 2018: Semergen
https://www.readbyqxmd.com/read/29452620/pathogen-specific-bacterial-imaging-in-nuclear-medicine
#2
REVIEW
Alvaro A Ordonez, Sanjay K Jain
When serious infections are suspected, patients are often treated empirically with broad-spectrum antibiotics while awaiting results that provide information on the bacterial class and species causing the infection, as well as drug susceptibilities. For deep-seated infections, these traditional diagnostic techniques often rely on tissue biopsies to obtain clinical samples which can be expensive, dangerous, and has the potential of sampling bias. Moreover, these procedures and results can take several days and may not always provide reliable information...
March 2018: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/29445954/normal-boundary-intersection-applied-as-multivariate-and-multiobjective-optimization-in-the-treatment-of-amoxicillin-synthetic-solution
#3
Deberton Moura, Vithor Barcelos, Gisella Rossana Lamas Samanamud, Alexandre Boscaro França, Renata Lofrano, Carla Cristina Almeida Loures, Luzia Lima Rezende Naves, Mateus Souza Amaral, Fabiano Luiz Naves
Amoxicillin is a useful antibiotic to combat bacterial infections. However, this drug can cause serious problems when discarded in waterways due to its great bioaccumulation potential. This compound can be treated via advanced oxidation processes (AOPs), which are capable of converting amoxicillin into carbon dioxide and water. In this context, the use of ozone as an oxidizer has excelled in amoxicillin degradation. This paper aims at treating a synthetic solution of amoxicillin (0.1 g L -1 ) in a reactor with ozone bubbling...
February 14, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29443761/haemolytic-uremic-syndrome-due-to-infection-with-adenovirus-a-case-report-and-literature-review
#4
Victoria Birlutiu, Rares Mircea Birlutiu
RATIONALE: Haemolytic-uremic syndrome is a rare but serious complication of bacterial and viral infections, which is characterized by the triad of: acute renal failure, microangiopathic haemolytic anemia and thrombocytopenia, sometimes severe, requiring peritoneal dialysis. In Europe, hemolytic-uremic syndrome (HUS) in paediatric pathology is primarily caused by Shiga toxin-producing Escherichia coli (STEC) O157, followed by O26. Beside these etiologies, there are other bacterial and viral infections, and also noninfectious ones that have been associated to lead to HUS as well: in the progression of neoplasia, medication-related, post-transplantation, during pregnancy or associated with the antiphospholipid syndrome, systemic lupus erythematosus or family causes with autosomal dominant or recessive inheritance...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29443508/development-of-an-infection-responsive-fluorescent-sensor-for-the-early-detection-of-urinary-catheter-blockage
#5
Scarlet Milo, Florianne B Acosta, Hollie J Hathaway, Laura A Wallace, Naing T Thet, A Toby A Jenkins
Formation of crystalline biofilms following infection by Proteus mirabilis can lead to encrustation and blockage of long-term indwelling catheters, with serious clinical consequences. We describe a simple sensor, placed within the catheter drainage bag, to alert of impending blockage via a urinary color change. The pH-responsive sensor is a dual-layered polymeric "lozenge", able to release the self-quenching dye 5(6)-carboxyfluorescein in response to the alkaline urine generated by the expression of bacterial urease...
February 14, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29434579/prevalence-and-molecular-characterization-of-campylobacter-spp-isolated-from-patients-with-diarrhea-in-shunyi-beijing
#6
Ying Li, Shuang Zhang, Mu He, Yanchun Zhang, Yanyan Fu, Hao Liang, Hongbo Jing, Yindong Li, Hongmei Ma, Maojun Zhang
Bacterial pathogens have been confirmed as the major cause of acute diarrhea among outpatients in China. In this study, 370 stool samples from the patients aged from 15 to 87 years old with diarrhea were collected over 12 months (from May 2016 to April 2017) in two hospitals in Shunyi, Beijing. Bacterial isolation was performed for the common enteric pathogens: Campylobacter, Salmonella, Shigella, Diarrheagenic Escherichia coli, and Vibrio parahaemolyticus for 370 samples. The filtration method was used for the Campylobacter isolation in this study...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29429889/comparison-with-the-osteoconductivity-and-bone-bonding-ability-of-the-iodine-supported-titanium-titanium-with-porous-oxide-layer-and-the-titanium-alloy-in-the-rabbit-model
#7
Tadashi Taga, Tamon Kabata, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Takashi Yamamoto, Tomoharu Takagi, Hiroyuki Tsuchiya
BACKGROUND: One of the serious postoperative complications associated with joint replacement is bacterial infection. In our recent investigations, iodine supported titanium implants demonstrated antibacterial activity in both in vitro and in vivo studies. The surfaces of the implants have porous anodic oxide layer with the antiseptic properties of iodine. According to the literature the titanium with porous anodic oxide have good osteoconductivity. But it is not clear whether the properties of iodine influence bone bonding of implants...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29429394/understanding-the-resistance-mechanism-of-penicillin-binding-protein-1a-mutant-against-cefotaxime-using-molecular-dynamic-simulation
#8
Esmaeil Behmard, Ali Najafi, Ali Ahmadi
Antibiotic resistance is a threatening challenge for global health, as the expansion of resistance to current antibiotics has made serious therapeutic problems. Genome mutations are key evolutionary mechanisms conferring antibiotic resistance in bacterial pathogens. For example, penicillin and cephalosporins resistance is mostly mediated by mutations in penicillin binding proteins to change the affinity of the drug. Accordingly, threonine point mutations were reported to develop antibiotic resistance in various bacterial infections including pneumococcal infections...
February 11, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29428235/sequence-and-structure-based-computational-analyses-of-gram-negative-tripartite-efflux-pumps-in-the-context-of-bacterial-membranes
#9
Timothy Travers, Katherine J Wang, Cesar A López, S Gnanakaran
Gram-negative multidrug resistance currently presents a serious threat to public health with infections effectively rendered untreatable. Multiple molecular mechanisms exist that cause antibiotic resistance and in addition, the last three decades have seen slowing rates of new drug development. In this review, we summarize the use of various computational techniques for investigating the mechanisms of multidrug resistance mediated by Gram-negative tripartite efflux pumps and membranes. Recent work in our lab combines data-driven sequence and structure analyses to study the interactions and dynamics of these bacterial components...
February 8, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29423317/design-and-production-of-conjugate-vaccines-against-s-paratyphi-a-using-an-o-linked-glycosylation-system-in-vivo
#10
Peng Sun, Chao Pan, Ming Zeng, Bo Liu, Haoyu Liang, Dongshu Wang, Xiankai Liu, Bin Wang, Yufei Lyu, Jun Wu, Li Zhu, Hengliang Wang
Enteric fever, mainly caused by Salmonella enterica serovar Paratyphi A, remains a common and serious infectious disease worldwide. As yet, there are no licensed vaccines against S. Paratyphi A. Biosynthesis of conjugate vaccines has become a promising approach against bacterial infection. However, the popular biosynthetic strategy using N-linked glycosylation systems does not recognize the specialized O-polysaccharide structure of S. Paratyphi A. Here, we describe an O-linked glycosylation approach, the only currently available glycosylation system suitable for an S...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29407232/t-cell-subsets-play-an-important-role-in-the-determination-of-the-clinical-outcome-of-helicobacter-pylori-infection
#11
REVIEW
Abdollah Jafarzadeh, Tiziana Larussa, Maryam Nemati, Shila Jalapour
Helicobacter pylori (H. pylori) is one of the most prevalent human pathogen and a persistent infection with this bacterium causes common pathologies, such as gastritis or peptic ulcers, and also less common but more serious pathologies, such as gastric cancer or gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The clinical outcome of gastrointestinal infection sustained by H. pylori is determined by the reciprocal interactions between virulence factors of the bacterium and host factors, including immune response genes...
January 30, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29407045/antibiofilm-activity-of-bioactive-hop-compounds-humulone-lupulone-and-xanthohumol-toward-susceptible-and-resistant-staphylococci
#12
Katerina Bogdanova, Magdalena Röderova, Milan Kolar, Katerina Langova, Martin Dusek, Petr Jost, Klara Kubelkova, Pavel Bostik, Jana Olsovska
Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of Humulus lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp...
January 30, 2018: Research in Microbiology
https://www.readbyqxmd.com/read/29404414/an-optimized-synthetic-bioinformatic-natural-product-antibiotic-sterilizes-multidrug-resistant-acinetobacter-baumannii-infected-wounds
#13
Xavier Vila-Farres, John Chu, Melinda A Ternei, Christophe Lemetre, Steven Park, David S Perlin, Sean F Brady
The antibiotic paenimucillin A was originally identified using a culture-independent synthetic-bioinformatic natural product (syn-BNP) discovery approach. Here we report on a bioinformatics-guided survey of paenimucillin A analogs that led to the discovery of paenimucillin C. Paenimucillin C inhibits the growth of multidrug-resistant (MDR) Acinetobacter baumannii clinical isolates, as well as other Gram-negative bacterial pathogens. In a rat cutaneous wound model, it completely sterilized MDR A. baumannii wound infections with no sign of rebound...
January 2018: MSphere
https://www.readbyqxmd.com/read/29399648/insights-into-key-interactions-between-vancomycin-and-bacterial-cell-wall-structures
#14
Feng Wang, Hongyu Zhou, Olatunde P Olademehin, Sung Joon Kim, Peng Tao
Vancomycin is a glycopeptide antibiotic used for the treatment of serious infections by Gram-positive pathogens. Vancomycin inhibits cell wall biosynthesis by targeting the d-Ala-d-Ala terminus of peptidoglycan (PG). The highly cross-linked heptapeptide aglycon structure of vancomycin is the d-Ala-d-Ala binding site. The first residue of vancomycin is N-methyl-leucine, which is crucial for the dipeptide binding. The removal of N-methyl-leucine by Edman degradation results in desleucyl-vancomycin devoid of antimicrobial activities...
January 31, 2018: ACS Omega
https://www.readbyqxmd.com/read/29392389/coumarin-a-novel-player-in-microbial-quorum-sensing-and-biofilm-formation-inhibition
#15
REVIEW
F Jerry Reen, José A Gutiérrez-Barranquero, María L Parages, Fergal O Gara
Antibiotic resistance is a growing threat worldwide, causing serious problems in the treatment of microbial infections. The discovery and development of new drugs is urgently needed to overcome this problem which has greatly undermined the clinical effectiveness of conventional antibiotics. An intricate cell-cell communication system termed quorum sensing (QS) and the coordinated multicellular behaviour of biofilm formation have both been identified as promising targets for the treatment and clinical management of microbial infections...
February 1, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29387980/hyperpyrexia-and-high-fever-as-a-predictor-for-serious-bacterial-infection-sbi-in-children-a-systematic-review
#16
REVIEW
Noa Rosenfeld-Yehoshua, Shiri Barkan, Ibrahim Abu-Kishk, Meirav Booch, Ruth Suhami, Eran Kozer
It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI. Our data sources were Embase, Medline, and Pubmed; from their inception until the last week of March 2017. The study selection were of cohort and case control studies comparing the incidence of SBI in children with hyperpyrexia with children with fever of 41 °C or less, and children with a temperature higher than 40 °C, with children with fever of 40 °C or less...
January 31, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29386122/comprehensive-analysis-of-the-lysine-acetylome-and-its-potential-regulatory-roles-in-the-virulence-of-streptococcus-pneumoniae
#17
Yu-Tong Liu, Ying Pan, Fubin Lai, Xing-Feng Yin, Ruiguang Ge, Qing-Yu He, Xuesong Sun
Protein lysine acetylation is a well-known modification with vital regulatory roles in various biological processes. Currently, the acetylated proteome in Streptococcus pneumoniae (S. pneumoniae) is not yet clear. Combining immune-affinity enrichment with mass spectrometry-based proteomics, we identified the first lysine acetylome of S. pneumoniae. In total, 653 lysine acetylated sites on 392 proteins were identified, which are involved in diverse important biological pathways, including gene expression and central metabolism...
January 28, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29384665/broad-spectrum-antibacterial-activity-of-proteolytically-stable-self-assembled-%C3%AE-%C3%AE-hybrid-peptide-gels
#18
Kamal Malhotra, Sudha Shankar, Rajkishor Rai, Yashveer Singh
Bacterial infections pose a serious threat to mankind and there is immense interest in the design and development of self-assembled peptide gels using ultra short peptides for antibacterial applications. The peptide gels containing natural amino acids suffer from poor stability against proteolytic enzymes. Therefore, there is a need to design and develop peptide gels with improved stability against proteolytic enzymes. In the present work, we report the synthesis and characterization of α/γ hybrid peptides, Boc-D-Phe-γ4-L-Phe-PEA (NH007) and Boc-L-Phe-γ4-L-Phe-PEA (NH009) to improve the proteolytic stability...
January 31, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29383666/clostridium-difficile-biofilm
#19
Claudia Vuotto, Gianfranco Donelli, Anthony Buckley, Caroline Chilton
Clostridium difficile infection (CDI) is an important healthcare-associated disease worldwide, mainly occurring after antimicrobial therapy. Antibiotics administered to treat a number of infections can promote C. difficile colonization of the gastrointestinal tract and, thus, CDI. A rise in multidrug resistant clinical isolates to multiple antibiotics and their reduced susceptibility to the most commonly used antibiotic molecules have made the treatment of CDI more complicated, allowing the persistence of C...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29378799/a-vaginal-tract-signal-detected-by-the-gbs-saers-system-elicits-transcriptomic-changes-and-enhances-murine-colonization
#20
Laura C Cook, Hong Hu, Mark Maienschein-Cline, Michael J Federle
Streptococcus agalactiae (Group B Streptococcus, GBS) can colonize the human vaginal tract leading to both superficial and serious infections in adults and neonates. To study bacterial colonization of the reproductive tract in a mammalian system, we employ a murine vaginal carriage model. Using RNASeq, the transcriptome of GBS growing in vivo during vaginal carriage was determined. Over one-quarter of the genes in GBS are found to be differentially regulated during in vivo colonization as compared to laboratory cultures...
January 29, 2018: Infection and Immunity
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