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https://www.readbyqxmd.com/read/28526080/post-weaning-diarrhea-in-pigs-risk-factors-and-non-colistin-based-control-strategies
#1
REVIEW
Mohamed Rhouma, John Morris Fairbrother, Francis Beaudry, Ann Letellier
Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used in swine for the oral treatment of intestinal infections caused by E. coli, and particularly of PWD. However, despite the effectiveness of this antibiotic in the treatment of PWD, several studies have reported high rates of colistin resistant E. coli in swine...
May 19, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28525670/hemoadsorption-treatment-of-patients-with-acute-infective-endocarditis-during-surgery-with-cardiopulmonary-bypass-a-case-series
#2
Karl Träger, Christian Skrabal, Guenther Fischer, Thomas Datzmann, Janpeter Schroeder, Daniel Fritzler, Jan Hartmann, Andreas Liebold, Helmut Reinelt
INTRODUCTION: Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery and valve replacement may be needed, posing additional risks to patients who may simultaneously suffer from septic shock. The combination of surgery bacterial spreadout and artificial cardiopulmonary bypass (CPB) surfaces results in a release of key inflammatory mediators leading to an overshooting systemic hyperinflammatory state frequently associated with compromised hemodynamic and organ function...
May 19, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28517960/a-rapid-seedling-resistance-assay-identifies-wild-tomato-lines-that-are-resistant-to-pseudomonas-syringae-pv-tomato-race-1
#3
Jana A Hassan, Yan-Ming Jane Zhou, Jennifer D Lewis
Bacterial speck caused by Pseudomonas syringae has historically been controlled by the Pto/Prf gene cluster. Emerging strains like P. syringae pv. tomato (Pst) race 1 overcome resistance conferred by Pto/Prf, and can cause serious crop loss under appropriate environmental conditions. We developed a rapid assay to screen wild tomato seedlings for resistance to Pst race 1. We established the seedling resistance assay using the well-characterized Pst race 0 strain, PstDC3000, that is recognized in tomato cultivars carrying Pto/Prf (PtoR) and causes disease in isogenic lines lacking this cluster (PtoS)...
May 18, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28511414/a-community-based-study-on-pelvic-inflammatory-disease-in-postmenopausal-females-microbiological-spectrum-and-socio-demographic-correlates
#4
Samreen Khan, M Athar Ansari, Shaista M Vasenwala, Zehra Mohsin
INTRODUCTION: Pelvic Inflammatory Disease (PID) is a common and serious complication of sexually transmitted diseases in young women but is rarely diagnosed in the postmenopausal women. Very few studies have been done regarding post-menopausal PID. AIM: To determine the burden of PID, associated micro-organisms, pathophysiology and risk factors among post-menopausal women of the community. MATERIALS AND METHODS: A cross-sectional study was conducted among 530 post-menopausal women in the registered field practice areas of the JN Medical College and Hospital, Aligarh, Uttar Pradesh, India...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506653/inhibition-of-denture-plaque-deposition-on-complete-dentures-by-2-methacryloyloxyethyl-phosphorylcholine-polymer-coating-a-clinical-study
#5
Kenji Ikeya, Fuminori Iwasa, Yuuki Inoue, Miya Fukunishi, Nana Takahashi, Kazuhiko Ishihara, Kazuyoshi Baba
STATEMENT OF PROBLEM: Denture plaque-associated infections are regarded as a source of serious dental and medical complications in the elderly population. Methods of managing this problem are needed. PURPOSE: The purpose of this clinical study was to evaluate the effects of treatment with a 2-methacryloyloxyethyl phosphorylcholine polymer, PMBPAz, on plaque deposition in complete dentures. MATERIAL AND METHODS: The study protocol was approved by the Ethics Committee of Showa University (#2013-013)...
May 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28501465/candiduria-evidence-based-approach-to-management-are-we-there-yet
#6
REVIEW
W A Alfouzan, R Dhar
Candiduria is considered one of the most controversial issues in patient management. Neither the diagnosis nor the optimal treatment options are standardized. This is further complicated by lack of defined laboratory criteria for diagnosis as most of the studies were set for bacterial rather than fungal urinary tract infection (UTI). Furthermore, since Candida species is a known commensal of the genitourinary tract its presence in the urine sample adds ambiguity to making a definitive diagnosis of candidal UTI...
May 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28491861/enteric-coated-and-highly-standardized-cranberry-extract-reduces-antibiotic-and-nonsteroidal-anti-inflammatory-drug-use-for-urinary-tract-infections-during-radiotherapy-for-prostate-carcinoma
#7
Alberto Bonetta, Giandomenico Roviello, Daniele Generali, Laura Zanotti, Maria Rosa Cappelletti, Chiara Pacifico, Francesco Di Pierro
INTRODUCTION: Worldwide, bacterial resistance to antibiotic therapy is a major concern for the medical community. Antibiotic resistance mainly affects Gram-negative bacteria that are an important cause of lower urinary tract infections (LUTIs). Pelvic irradiation for prostate cancer is a risk factor for LUTIs. Cranberry extract is reported to reduce the incidence of LUTIs. The prophylactic role of an enteric-coated, highly standardized cranberry extract (VO370(®)) in reducing LUTI episodes, urinary discomfort, and nonsteroidal anti-inflammatory drug (NSAID) and antibiotic use during radiotherapy for prostate carcinoma was evaluated...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28484498/evaluating-the-trends-of-bloodstream-infections-among-pediatric-and-adult-patients-at-a-teaching-hospital-of-kathmandu-nepal-role-of-drug-resistant-pathogens
#8
Narayan Prasad Parajuli, Hridaya Parajuli, Roshan Pandit, Jyotsna Shakya, Puspa Raj Khanal
Bloodstream infections (BSIs) are among the significant causes of morbidity and mortality for patients of all age groups. However, very little is known about the trends of bacterial bloodstream infections and antimicrobial susceptibilities among pediatric and adult population from Nepal. In this study, we have investigated the different etiological agents responsible for bloodstream infections among pediatric and adult patients and the role of drug resistant organisms in these infections at a tertiary care teaching hospital of Kathmandu, Nepal...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28483953/ceftolozane-tazobactam-activity-against-pseudomonas-aeruginosa-clinical-isolates-from-us-hospitals-report-from-an-antimicrobial-surveillance-program-pacts-2012-2015
#9
Dee Shortridge, Mariana Castanheira, Michael A Pfaller, Robert K Flamm
The activity of ceftolozane-tazobactam was compared to the activity of 7 antimicrobials against 3,851 Pseudomonas aeruginosa isolates collected from 32 US hospitals in the Program to Assess Ceftolozane-Tazobactam Susceptibility from 2012-2015. Ceftolozane-tazobactam and comparator susceptibilities were determined using the CLSI broth microdilution method at a central monitoring laboratory. For ceftolozane-tazobactam, 97.0% of the isolates were susceptible. Susceptibilities of the other antibacterials tested were: amikacin, 96...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28483701/prevention-of-bacterial-adhesion-to-zwitterionic-biocompatible-mesoporous-glasses
#10
S Sánchez-Salcedo, A García, María Vallet-Regí
Novel materials, based on Mesoporous Bioactive Glasses (MBGs) in the ternary system SiO2-CaO-P2O5, decorated with (3-aminopropyl)triethoxysilane (APTES) and subsequently with amino acid Lysine (Lys), by post-grafting method on the external surface of the glasses (named MBG-NH2 and MBG-Lys), are reported. The surface functionalization with organic groups did not damage the mesoporous network and their structural and textural properties were also preserved despite the high solubility of MBG matrices. The incorporation of Lys confers a zwitterionic nature to these MBG materials due to the presence of adjacent amine and carboxylic groups in the external surface...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28482836/assessment-of-herbal-drugs-for-promising-anti-candida-activity
#11
Sameh S M Soliman, Mohammad H Semreen, Ali A El-Keblawy, Arbab Abdullah, Priya Uppuluri, Ashraf S Ibrahim
BACKGROUND: Microbial infections are diverse and cause serious human diseases. Candida albicans infections are serious healthcare-related infections that are complicated by its morphological switching from yeast to hyphae, resistant biofilm formation and mixed infections with bacteria. Due to the increase in drug resistance to currently used antimicrobial agents and the presence of undesirable side effects, the need for safe and effective novel therapies is important. Compounds derived from plants are known for their medicinal properties including antimicrobial activities...
May 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28482226/microbially-and-phytofabricated-agnps-with-different-mode-of-bactericidal-action-were-identified-to-have-comparable-potential-for-surface-fabrication-of-central-venous-catheters-to-combat-staphylococcus-aureus-biofilm
#12
Roshmi Thomas, Shiji Mathew, A R Nayana, Jyothis Mathews, E K Radhakrishnan
In spite of newer innovations and process improvements, catheter related infections still pose serious threat to hospitalized patients. Silver nanoparticles (AgNPs) are well demonstrated to have antibacterial properties and also have been implemented for surface fabrication of many indwelling medical devices. So, herein we sought to compare the performance of AgNPs generated through biogenic routes using bacteria and plant extract for their antibacterial and antibiofilm potential against biofilm forming Staphylococcus aureus...
April 28, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28481506/functional-silver-nanocomposites-as-broad-spectrum-antimicrobial-and-biofilm-disrupting-agents
#13
Qianqian Guo, Yu Zhao, Xiaomei Dai, Tianqi Zhang, Yunjian Yu, Xinge Zhang, Chaoxing Li
Biofilms' tolerance has become a serious clinical concern due to their formidable resistance to conventional antibiotics and prevalent virulence. Therefore, there is an urgent need to develop alternative antimicrobial agents to eradicate biofilms but avoid using antibiotics. Herein, we successfully developed polymer functional silver nanocomposites by reduction of silver nitrate in the presence of a biocompatible carbohydrate polymer and a membrane-disrupting cationic polymer. The nanocomposites presented effective antimicrobial activity against Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus and Bacillus amyloliquefaciens)...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28480404/inhibitory-activity-of-mangiferin-on-helicobacter-pylori-induced-inflammation-in-human-gastric-carcinoma-ags-cells
#14
Qiu-Jie Zhang, Lu Yue
BACKGROUND: Gastric cancer is a serious health issue caused by H. pylori and claims more lives in developing and undeveloped countries. Hence, the need for a natural drug with several pharmacological activities with no adverse effect are highly recommended. The target of this study was to verify the anti-H. pyloric efficacy of mangiferin (MF) on H. pylori-infected AGS cells. MATERIALS AND METHODS: AGS cells were co-cultured with H. pylori and incubated with increased concentration of MF (10, 20, 50 and 100 μg/mL) or amoxicillin (AMX) and DMSO (control) group to assess its anti-H...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28471863/serious-bacterial-infections-in-hospitalized-febrile-infants-in-the-first-and-second-months-of-life
#15
Lior Carmon, Aviv Goldbart, David Greenberg, Shalom Ben-Shimol
OBJECTIVE: Most protocols evaluating serious bacterial infection (SBI) risk in febrile infants, classify neonates <30 days as high-risk (HR), while other protocols do not distinguish between infants <30 and 30-60 days. We compared SBI rates in febrile infants at the first and the second months of life. METHODS: This was a retrospective, population-based, cohort study. All febrile infants ≤60 days hospitalized in southern-Israel, January 2013 through May 2014, were included...
May 3, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28466611/occult-bacteremia-should-we-look-for-the-needle-in-the-haystack
#16
Neta Baram, Orli Megged, Giora Weiser
BACKGROUND: Once a well-recognized entity, occult bacteremia (OB) is no longer a significant or serious bacterial infection. First following the introduction of the Haemophilus influenzae type B vaccine and now with the implementation of the conjugate pneumococcal vaccine (PCV), the number of cases has declined significantly. This has led to a change in many published guidelines to avoid taking blood cultures in fully vaccinated children presenting with fever. In Israel, the introduction of the PCV13 is now widespread...
November 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28465626/synthesis-and-biological-evaluation-of-indole-core-based-derivatives-with-potent-antibacterial-activity-against-resistant-bacterial-pathogens
#17
Wei Hong, Jingyang Li, Zhe Chang, Xiaoli Tan, Hao Yang, Yifan Ouyang, Yanhui Yang, Sargit Kaur, Ian C Paterson, Yun Fong Ngeow, Hao Wang
The emergence of drug resistance in bacterial pathogens is a growing clinical problem that poses difficult challenges in patient management. To exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. Here we describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by molecular modeling to be potential glycosyltransferase inhibitors. Twenty of these derivatives were found to show in vitro inhibition of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus...
May 3, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28463660/increased-drug-resistance-of-meticillin-resistant-staphylococcus-aureus-biofilms-formed-on-a-mouse-dermal-chip-model
#18
Shiro Jimi, Motoyasu Miyazaki, Tohru Takata, Hiroyuki Ohjimi, Sadanori Akita, Shuuji Hara
PURPOSE: Meticillin-resistant Staphylococcus aureus (MRSA) biofilm formation in humans is of serious clinical concern. Previous in vitro studies have been performed with biofilms grown only on inorganic substrates; therefore, we investigated the vancomycin (VCM) resistance of MRSA biofilms grown on skin tissue. METHODOLOGY: We established a novel tissue substrate model, namely MRSA grown on segments of mouse skin tissue (dermal chips, DCs), and compared its resistance capacity against VCM with that of MRSA biofilms grown on plastic chips (PCs)...
April 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28462212/animal-models-of-hospital-acquired-pneumonia-current-practices-and-future-perspectives
#19
REVIEW
Kenny Bielen, Bart 's Jongers, Surbhi Malhotra-Kumar, Philippe G Jorens, Herman Goossens, Samir Kumar-Singh
Lower respiratory tract infections are amongst the leading causes of mortality and morbidity worldwide. Especially in hospital settings and more particularly in critically ill ventilated patients, nosocomial pneumonia is one of the most serious infectious complications frequently caused by opportunistic pathogens. Pseudomonas aeruginosa is one of the most important causes of ventilator-associated pneumonia as well as the major cause of chronic pneumonia in cystic fibrosis patients. Animal models of pneumonia allow us to investigate distinct types of pneumonia at various disease stages, studies that are not possible in patients...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28460302/silver-decorated-copper-oxide-ag-cuo-nanocomposite-enhances-ros-mediated-bacterial-architecture-collapse
#20
Mei-Lang Kung, Ming-Hong Tai, Pei-Ying Lin, Deng-Chyang Wu, Wen-Jeng Wu, Bi-Wen Yeh, Huey-Shan Hung, Chao-Hung Kuo, Yun-Wen Chen, Shu-Ling Hsieh, Shuchen Hsieh
The increasing prevalence of hospital-acquired infection and the evolution and increasing resistance of pathogens toward antibiotics can cause serious health problems and disease-related mortality. In this study, we introduce a simple process and inexpensive method to synthesize CuO nanoparticles and silver-functionalized copper oxide (Ag@CuO) nanocomposites as well as to validate their potential antibacterial efficiency against the following three common nosocomial infection-associated bacterial pathogens: E...
April 23, 2017: Colloids and Surfaces. B, Biointerfaces
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