Do-Yeon Cho, Shaoyan Zhang, Daniel Skinner, Connor G Koch, Metta J Smith, Dong-Jin Lim, Jessica W Grayson, Guillermo J Tearney, Steven M Rowe, Bradford A Woodworth
BACKGROUND: We previously discovered that Korean red ginseng aqueous extract (RGAE) potentiates the TMEM16A channel, improved mucociliary transport (MCT) parameters in CF nasal epithelia in vitro, and thus could serve as a therapeutic strategy to rescue the MCT defect in cystic fibrosis (CF) airways. The hypothesis of this study is that RGAE can improve epithelial Cl- secretion, MCT, and histopathology in an in-vivo CF rat model. METHODS: Seventeen 4-month old CFTR-/- rats were randomly assigned to receive daily oral control (saline, n = 9) or RGAE (Ginsenosides 0...
September 11, 2023: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society