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Korean ginseng

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https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#1
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
July 14, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28707603/ginseng-for-the-treatment-of-hypertension-a-systematic-review-and-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#2
Hye Won Lee, Hyun- Ja Lim, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
BACKGROUND: Evidence of ginseng for reducing blood pressure (BP) in hypertensive patients is controversial. This systematic review updated the previous reviews and evidence for it. METHODS: Ten databases were searched from their inception through October 2016, without language restriction. Randomized clinical trials (RCTs) were included if any types of ginseng were tested as the sole treatment or as an adjunct to other treatments for pre-hypertension or hypertension...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28701883/20s-protopanaxadiol-an-aglycosylated-ginsenoside-metabolite-induces-hepatic-stellate-cell-apoptosis-through-liver-kinase-b1-amp-activated-protein-kinase-activation
#3
Sang Mi Park, Eun Hye Jung, Jae Kwang Kim, Kyung Hwan Jegal, Chung A Park, Il Je Cho, Sang Chan Kim
BACKGROUND: Previously, we reported that Korean Red Ginseng inhibited liver fibrosis in mice and reduced the expressions of fibrogenic genes in hepatic stellate cells (HSCs). The present study was undertaken to identify the major ginsenoside responsible for reducing the numbers of HSCs and the underlying mechanism involved. METHODS: Using LX-2 cells (a human immortalized HSC line) and primary activated HSCs, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) assays were conducted to examine the cytotoxic effects of ginsenosides...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701882/comparison-of-anticancer-activities-of-korean-red-ginseng-derived-fractions
#4
Kwang-Soo Baek, Young-Su Yi, Young-Jin Son, Deok Jeong, Nak Yoon Sung, Adithan Aravinthan, Jong-Hoon Kim, Jae Youl Cho
BACKGROUND: Korean Red Ginseng (KRG) is an ethnopharmacological plant that is traditionally used to improve the body's immune functions and ameliorate the symptoms of various diseases. However, the antitumorigenic effects of KRG and its underlying molecular and cellular mechanisms are not fully understood in terms of its individual components. In this study, in vitro and in vivo antitumorigenic activities of KRG were explored in water extract (WE), saponin fraction (SF), and nonsaponin fraction (NSF)...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701873/molecular-differentiation-of-russian-wild-ginseng-using-mitochondrial-nad7-intron-3-region
#5
Guisheng Li, Yan Cui, Hongtao Wang, Woo-Saeng Kwon, Deok-Chun Yang
BACKGROUND: Cultivated ginseng is often introduced as a substitute and adulterant of Russian wild ginseng due to its lower cost or misidentification caused by similarity in appearance with wild ginseng. The aim of this study is to develop a simple and reliable method to differentiate Russian wild ginseng from cultivated ginseng. METHODS: The mitochondrial NADH dehydrogenase subunit 7 (nad7) intron 3 regions of Russian wild ginseng and Chinese cultivated ginseng were analyzed...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701870/nuclear-factor-kappa-b-and-activator-protein-1-mediated-immunostimulatory-activity-of-compound-k-in-monocytes-and-macrophages
#6
Woo Seok Yang, Young-Su Yi, Donghyun Kim, Min Ho Kim, Jae Gwang Park, Eunji Kim, Sang Yeol Lee, Keejung Yoon, Jong-Hoon Kim, Junseong Park, Jae Youl Cho
BACKGROUND: Compound K (CK) is a bioactive derivative of ginsenoside Rb1 in Panax ginseng (Korean ginseng). Its biological and pharmacological activities have been studied in various disease conditions, although its immunomodulatory role in innate immunity mediated by monocytes/macrophages has been poorly understood. In this study, we aimed to elucidate the regulatory role of CK on cellular events mediated by monocytes and macrophages in innate immune responses. METHODS: The immunomodulatory role of CK was explored by various immunoassays including cell-cell adhesion, fibronectin adhesion, cell migration, phagocytic uptake, costimulatory molecules, reactive oxygen species production, luciferase activity, and by the measurement of mRNA levels of proinflammatory genes...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701868/protective-effect-of-korean-red-ginseng-against-fk506-induced-damage-in-llc-pk1-cells
#7
Dahae Lee, Ki Sung Kang, Jae Sik Yu, Jung-Yoon Woo, Gwi Seo Hwang, Dae-Woon Eom, Seung-Hoon Baek, Hye Lim Lee, Ki Hyun Kim, Noriko Yamabe
BACKGROUND: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated. METHODS: LLC-PK1 cells were exposed to FK506 with KRG and cell viability was measured...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701867/effects-of-korean-ginseng-berry-on-skin-antipigmentation-and-antiaging-via-foxo3a-activation
#8
Juewon Kim, Si Young Cho, Su Hwan Kim, Donghyun Cho, Sunmi Kim, Chan-Woong Park, Takahiko Shimizu, Jae Youl Cho, Dae Bang Seo, Song Seok Shin
BACKGROUND: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701866/inhibitory-effects-of-ginsenosides-on-basic-fibroblast-growth-factor-induced-melanocyte-proliferation
#9
Ji Eun Lee, Jong Il Park, Cheol Hwan Myung, Jae Sung Hwang
BACKGROUND: UV-B-exposed keratinocytes secrete various paracrine factors. Among these factors, basic fibroblast growth factor (bFGF) stimulates the proliferation of melanocytes. Ginsenosides, the major active compounds of ginseng, are known to have broad pharmacological effects. In this study, we examined the antiproliferative effects of ginsenosides on bFGF-induced melanocyte proliferation. METHODS: We investigated the inhibitory effects of Korean Red Ginseng and ginsenosides from Panax ginseng on bFGF-induced proliferation of melan-a melanocytes...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28701863/inhibition-of-hypoxia-induced-cyclooxygenase-2-by-korean-red-ginseng-is-dependent-on-peroxisome-proliferator-activated-receptor%C3%A2-gamma
#10
Heewon Song, Young Joo Lee
BACKGROUND: Korean Red Ginseng (KRG) is a traditional herbal medicine made by steaming and drying fresh ginseng. It strengthens the endocrine and immune systems to ameliorate various inflammatory responses. The cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway has important implications for inflammation responses and tumorigenesis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates not only adipogenesis and lipid homeostasis, but also angiogenesis and inflammatory responses...
July 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28690526/a-case-of-t-cell-lymphoma-treated-by-korean-medicine-therapy-alone
#11
Jun-Suk Jung, Dong-Hyun Lee, Shin Seong, Sung Su Kim
This case report is aimed to investigate the effects of Korean medicine therapy (KMT) alone including oral herbal medicine on treating a patient with atypical peripheral CD4 T cell lymphoma. The oral medicine used is Hyunamdan made of heat-processed ginseng and Hangamdan S. An 87-year-old man who was diagnosed as having atypical peripheral CD4 T cell lymphoma on November 30, 2015 was treated with KMT from December 23, 2015 until October 22, 2016. The effectiveness of therapies was evaluated with PET-CT scan as well as the change of the main sign of lymphoma...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28568743/interventions-for-treatment-and-or-prevention-of-alcohol-hangover-systematic-review
#12
REVIEW
Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C Verster
OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: "Alcohol," "Ethanol," and "C2 H5 OH," in combination with the terms "Hangover," "Treatment," and "Prevention." The search comprised studies listed between January 1, 2009 and June 30, 2016...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28558522/saponin-extracts-induced-apoptosis-of-endometrial-cells-from-women-with-endometriosis-through-modulation-of-mir-21-5p
#13
Ji Hyun Park, Seung Kyun Lee, Min Kyoung Kim, Jae Hoon Lee, Bo Hyun Yun, Joo Hyun Park, Seok Kyo Seo, SiHyun Cho, Young Sik Choi
Among the several components in Korean red ginseng, the saponin components are known to have various pharmacologic activities. The objective of this study was to evaluate therapeutic effects of saponin extracts from Korean red ginseng on endometriosis and to identify microRNAs (miRNAs) associated with saponin treatment. This is an in vitro study which used human endometrial stromal cells (HESCs) obtained from patients who underwent laparoscopic surgery for endometriosis and other benign conditions. Human endometrial stromal cells were treated with saponin extracts, and microarray profiling was performed...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28544385/korean-red-ginseng-extract-enhances-the-anticancer-effects-of-sorafenib-through-abrogation-of-creb-and-c-jun-activation-in-renal-cell-carcinoma
#14
Chulwon Kim, Jong Hyun Lee, Seung Ho Baek, Jeong-Hyeon Ko, Dongwoo Nam, Kwang Seok Ahn
Although application of sorafenib in the treatment of human renal cell carcinoma (RCC) remains one of the best examples of successful targeted therapy, majority of RCC patients suffer from its side effects as well as develop resistance to this targeted therapy. Thus, there is a need to promote novel alternative therapies for the treatment of RCC. In this study, we investigated whether Korean red ginseng extract (KRGE) could inhibit the proliferation and induce chemosensitization in human renal cancer cells...
May 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28527763/aluminium-resistant-plant-growth-promoting-bacteria-induce-overexpression-of-aluminium-stress-related-genes-in-arabidopsis-thaliana-and-increase-the-ginseng-tolerance-against-aluminium-stress
#15
Mohamed El-Agamy Farh, Yeon-Ju Kim, Johan Sukweenadhi, Priyanka Singh, Deok-Chun Yang
Panax ginseng is an important cash crop in the Asian countries due to its pharmaceutical effects, however the plant is exposed to various abiotic stresses, lead to reduction of its quality. One of them is the Aluminum (Al) accumulation. Plant growth promoting bacteria which able to tolerate heavy metals has been considered as a new trend for supporting the growth of many crops in heavy metal occupied areas. In this study, twelve bacteria strains were isolated from rhizosphere of diseased Korean ginseng roots located in Gochang province, Republic of Korea and tested for their ability to grow in Al-embedded broth media...
July 2017: Microbiological Research
https://www.readbyqxmd.com/read/28462122/rg3-enriched-korean-red-ginseng-enhances-blood-pressure-stability-in-spontaneously-hypertensive-rats
#16
Harsha Nagar, Sujeong Choi, Saet-Byel Jung, Byeong Hwa Jeon, Cuk-Seong Kim
BACKGROUND: Korean Red Ginseng (Panax ginseng) has been shown to exert antihypertensive effects. In particular, ginsenoside Rg3 is thought to be a potent modulator of vascular function. The present study was performed to examine the antihypertensive efficacy of Korean Red Ginseng (KRG) extract and Rg3-enriched KRG (REKRG) extract. METHODS: Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) were divided into six groups (WKY control, WKY-KRG, WKY-REKRG, SHR control, SHR-KRG, and SHR-REKRG), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at the carotid artery, followed by injection of 3 mg/kg KRG or 3 mg/kg REKRG...
September 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28461813/a-case-report-of-metastatic-breast-cancer-treated-with-korean-medicine-therapy-as-a-substitute-for-chemotherapy
#17
Dong-Hyun Lee, Sung-Su Kim, Shin Seong
The purpose of this case report is to show the potential benefit of Korean medicine therapy for treating multiple metastatic breast cancer. A 45-year-old Korean woman was diagnosed with right breast invasive ductal carcinoma in August 2012 but did not receive any treatment until October 2015 when she was diagnosed with stage 4 right breast cancer with multiple liver, bone, mesentery, retroperitoneum, and axillary lymph node metastases. After chemo-port insertion, she was treated with palliative chemotherapy and the first line of trastuzumab and paclitaxel, and the port was removed due to port infection...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28447311/attenuation-of-glutamate-induced-excitotoxicity-by-withanolide-a-in-neuron-like-cells-role-for-pi3k-akt-mapk-signaling-pathway
#18
Nawab John Dar, Naresh Kumar Satti, Prabhu Dutt, Abid Hamid, Muzamil Ahmad
Glutamate-induced excitotoxicity is one of the major underlying mechanisms for neurodegenerative diseases. Efforts are being made to treat such conditions with an array of natural compounds that can modulate the release of glutamate or the underlying mechanisms associated with it. Withania somnifera extract has potent pharmacologic activity similar to that of Korean Ginseng tea and is used to treat several neuronal disorders. However, to date, little efforts have been made to evaluate individual constituents of this plant for neurodegenerative disorders...
April 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28413328/effect-of-korean-red-ginseng-intake-on-the-survival-duration-of-human-immunodeficiency-virus-type-1-patients
#19
Young-Keol Cho, Jung-Eun Kim
BACKGROUND: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection. METHODS: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947 ± 4,943 g) for 86 ± 63 mo...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28413325/the-psychopharmacological-activities-of-vietnamese-ginseng-in-mice-characterization-of-its-psychomotor-sedative-hypnotic-antistress-anxiolytic-and-cognitive-effects
#20
Irene Joy I Dela Peña, Hee Jin Kim, Chrislean Jun Botanas, June Bryan de la Peña, Thi Hong Van Le, Minh Duc Nguyen, Jeong Hill Park, Jae Hoon Cheong
BACKGROUND: Panax vietnamensis Ha et Grushv. or Vietnamese ginseng (VG) is a recently discovered ginseng species. Studies on its chemical constituents have shown that VG is remarkably rich in ginseng saponins, particularly ocotillol saponins. However, the psychopharmacological effects of VG have not been characterized. Thus, in the present study we screened the psychopharmacological activities of VG in mice. METHODS: VG extract (VGE) was orally administered to mice at various dosages to evaluate its psychomotor (open-field and rota-rod tests), sedative-hypnotic (pentobarbital-induced sleeping test), antistress (cold swimming test), anxiolytic (elevated plus-maze test), and cognitive (Y-maze and passive-avoidance tests) effects...
April 2017: Journal of Ginseng Research
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