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https://www.readbyqxmd.com/read/29100799/two-new-dammarane-type-triterpene-saponins-from-korean-red-ginseng-and-their-anti-inflammatory-effects
#1
Le Ba Vinh, Yunjeong Lee, Yoo Kyong Han, Jong Seong Kang, Jung Up Park, Young Ran Kim, Seo Young Yang, Young Ho Kim
Panax ginseng has been the subject of extensive research on potential medicinal materials. The goal of this study was search the chemical constituents and biological activities of processed Panax ginseng, Korean red ginseng. Our efforts led to the isolation eleven compounds (1-11) including two new compounds 1 and 2 from Korean red ginseng using various chromatographic techniques. Chemical structures of isolated compounds were demonstrated by spectroscopic methods (1D-, 2D-NMR, and HR-ESI-MS). The anti-inflammatory effects of the compounds were investigated by inhibiting IL-6 and TNF-α secretion in LPS-activated RAW264...
October 31, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29090563/-comparative-analysis-on-industrial-standardization-degree-of-chinese-and-korean-ginseng
#2
Qiao Chu, Xing-Jun Xi, He-Yan Wang, Ding-Hua Si, Fei Tang, Tao Lan
Panax ginseng is a well-known medicinal plant all over the world. It has high nutritional value and medicinal value. China and South Korea are the major countries in the world for ginseng cultivation, production and exportation. China's ginseng production accounts for more than half of the world, but the output value is less than that of Korea. The standardization process of ginseng industry plays an important role. This paper makes a detailed analysis of the Chinese and Korean ginseng national standards and the standardization process, and makes a detailed comparative analysis of the categories, standard contents, index selection, age, implementation and promotion status of the Chinese and Korean ginseng standards...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29082711/-research-on-ginseng-trade-competitiveness-between-china-and-korea
#3
Min-Tong Xin, Guang Yang, Xiao-Jing Tang
Ginseng is one of China's valuable Chinese herbal medicines, with a long using history. Ginseng has worldwide reputation, and widely used in food, medicine, health products, cosmetics and other production. China and South Korea have a big ginseng industrial, and sharing half of the export market. The ginseng export competitiveness analysis seems important and necessary between China and South Korea. In this paper, the data of customs and trade of ginseng in COMTRADE database were studied, and ginseng export competitiveness was analyzed between China and Korea...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29021709/subacute-oral-toxicity-and-bacterial-mutagenicity-study-of-korean-red-ginseng-oil
#4
Hwi Won Seo, Jae Hyun Suh, Seung-Ho So, Jong-Soo Kyung, Yong-Soon Kim, Chang-Kyun Han
BACKGROUND: Red ginseng oil (RGO) is produced by supercritical CO2 extraction of secondary products derived from Korean Red Ginseng extract. As the use of RGO has increased, product safety concerns have become more important. METHODS: In the present study, the subacute oral toxicity and bacterial reverse mutagenicity of RGO were evaluated. Sprague-Dawley rats were orally administered with RGO for 28 d by gavage. Daily RGO dose concentrations were 0 mg/kg body weight (bw), 500 mg/kg bw, 1,000 mg/kg bw, or 2,000 mg/kg bw per day...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021703/ginsenoside-rg3-enriched-red-ginseng-extract-inhibits-platelet-activation-and-in%C3%A2-vivo-thrombus-formation
#5
Dahye Jeong, Muhammad Irfan, Sung-Dae Kim, Suk Kim, Jun-Hwan Oh, Chae-Kyu Park, Hyun-Kyoung Kim, Man Hee Rhee
BACKGROUND: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021700/ginsenoside-rg12-a-new-dammarane-type-triterpene-saponin-from-panax-ginseng-root
#6
Dong Gu Lee, Jaemin Lee, Ik-Hyun Cho, Hak-Jae Kim, Sang-Won Lee, Young-Ock Kim, Chun-Gun Park, Sanghyun Lee
BACKGROUND: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. METHODS: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. RESULTS AND CONCLUSION: New dammarane-type triterpene saponin was isolated for the first time from nature...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021698/nonsaponin-fractions-of-korean-red-ginseng-extracts-prime-activation-of-nlrp3-inflammasome
#7
Byung-Cheol Han, Huijeong Ahn, Jiseon Lee, Eunsaem Jeon, Sanghoon Seo, Kyoung Hwa Jang, Seung-Ho Lee, Cheon Ho Kim, Geun-Shik Lee
BACKGROUND: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. METHODS: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021694/korean-red-ginseng-extract-induces-angiogenesis-through-activation-of-glucocorticoid-receptor
#8
Wai-Nam Sung, Hoi-Hin Kwok, Man-Hee Rhee, Patrick Ying-Kit Yue, Ricky Ngok-Shun Wong
BACKGROUND: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021690/effect-of-korean-red-ginseng-in-chronic-liver-disease
#9
REVIEW
Tae Young Park, Meegun Hong, Hotaik Sung, Sangyeol Kim, Ki Tae Suk
Chronic liver disease, one of the most common diseases, typically arises from nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma. Therefore, there is a pressing need for improved treatment strategies. Korean Red Ginseng has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of Korean Red Ginseng on chronic liver disease, a condition encompassing nonalcoholic fatty liver disease, alcoholic liver disease, chronic viral hepatitis, and hepatocellular carcinoma, as supported by experimental evaluation and clinical investigation...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021689/applications-of-molecular-markers-in-the-discrimination-of-panax-species-and-korean-ginseng-cultivars-panax-ginseng
#10
REVIEW
Ick Hyun Jo, Young Chang Kim, Dong Hwi Kim, Kee Hong Kim, Tae Kyung Hyun, Hojin Ryu, Kyong Hwan Bang
The development of molecular markers is one of the most useful methods for molecular breeding and marker-based molecular associated selections. Even though there is less information on the reference genome, molecular markers are indispensable tools for determination of genetic variation and identification of species with high levels of accuracy and reproducibility. The demand for molecular approaches for marker-based breeding and genetic discriminations in Panax species has greatly increased in recent times and has been successfully applied for various purposes...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29018312/diffusible-and-volatile-antifungal-compounds-produced-by-an-antagonistic-bacillus-velezensis-g341-against-various-phytopathogenic-fungi
#11
Seong Mi Lim, Mi-Young Yoon, Gyung Ja Choi, Yong Ho Choi, Kyoung Soo Jang, Teak Soo Shin, Hae Woong Park, Nan Hee Yu, Young Ho Kim, Jin-Cheol Kim
The aim of this study was to identify volatile and agar-diffusible antifungal metabolites produced by Bacillus sp. G341 with strong antifungal activity against various phytopathogenic fungi. Strain G341 isolated from four-year-old roots of Korean ginseng with rot symptoms was identified as Bacillus velezensis based on 16S rDNA and gyrA sequences. Strain G341 inhibited mycelial growth of all phytopathogenic fungi tested. In vivo experiment results revealed that n-butanol extract of fermentation broth effectively controlled the development of rice sheath blight, tomato gray mold, tomato late blight, wheat leaf rust, barley powdery mildew, and red pepper anthracnose...
October 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28989572/effects-of-ingredients-of-korean-brown-rice-cookies-on-attenuation-of-cholesterol-level-and-oxidative-stress-in-high-fat-diet-fed-mice
#12
Sun Hee Hong, Mijeong Kim, Minji Woo, Yeong Ok Song
BACKGROUND/OBJECTIVES: Owing to health concerns related to the consumption of traditional snacks high in sugars and fats, much effort has been made to develop functional snacks with low calorie content. In this study, a new recipe for Korean rice cookie, dasik, was developed and its antioxidative, lipid-lowering, and anti-inflammatory effects and related mechanisms were elucidated. The effects were compared with those of traditional rice cake dasik (RCD), the lipid-lowering effect of which is greater than that of traditional western-style cookies...
October 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28981384/the-effects-of-a-korean-ginseng-ginst15-on-hypo-pituitary-adrenal-and-oxidative-activity-induced-by-intense-work-stress
#13
Shawn D Flanagan, William H DuPont, Lydia K Caldwell, Vincent H Hardesty, Emily C Barnhart, Matthew K Beeler, Emily M Post, Jeff S Volek, William J Kraemer
The effect of GINST15, an enzyme fermented ginseng supplement, on hormonal and inflammatory responses to physical stress in humans is unknown. The purpose of this investigation was to examine the constitutive and stress-induced effects of GINST15 supplement on hypo-pituitary-adrenal (HPA) and antioxidant activity in addition to muscle damage. Ten women (age: 38.7 ± 7.8 years; height: 163.81 ± 4.4 cm; body mass 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 177.4 ± 5...
October 5, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28927488/investigation-of-the-antifatigue-effects-of-korean-ginseng-on-professional-athletes-by-gas-chromatography-time-of-flight-mass-spectrometry-based-metabolomics
#14
Bei Yan, Yao Liu, Aixin Shi, Zhihong Wang, Jiye Aa, Xiaoping Huang, Yi Liu
Ginseng is usually used for alleviating fatigue. The purpose of this paper was to evaluate the regulatory effect of Korean ginseng on the metabolic pattern in professional athletes, and, further, to explore the underlying mechanism of the antifatigue effect of Korean ginseng. GC-time-of-flight-MS was used to profile serum samples from professional athletes before training and after 15 and 30 day training, and professional athletes administered with Korean ginseng in the meanwhile. Biochemical parameters of all athletes were also analyzed...
September 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28919589/from-woohwang-cheongsimwon-to-ginseng-the-history-of-medicine-use-in-the-joseon-era
#15
Seong-Su Kim
In Korean traditional medicine, though herbal decoction, acupuncture, and moxibustion are all used to treat diseases, restorative medicines are the most widely preferred treatment method. This paper explores the historical background of restorative herbal medicines and ginseng among the Korean public and Korean traditional medicine practice. It also seeks to clarify how social and cultural perspectives on drug use have changed since restorative medicine became mainstream during the Joseon era. Drug use tendencies were affected by the medical system of the Joseon Dynasty, patients' desires for reliable treatment, and perceptions of the human body and the causes of disease...
August 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/28914759/isoform-sequencing-provides-a-more-comprehensive-view-of-the-panax-ginseng-transcriptome
#16
Ick-Hyun Jo, Jinsu Lee, Chi Eun Hong, Dong Jin Lee, Wonsil Bae, Sin-Gi Park, Yong Ju Ahn, Young Chang Kim, Jang Uk Kim, Jung Woo Lee, Dong Yun Hyun, Sung-Keun Rhee, Chang Pyo Hong, Kyong Hwan Bang, Hojin Ryu
Korean ginseng (Panax ginseng C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides. To obtain transcriptomic data that offers a more comprehensive view of functional genomics in P. ginseng, we generated genome-wide transcriptome data from four different P. ginseng tissues using PacBio isoform sequencing (Iso-Seq) technology. A total of 135,317 assembled transcripts were generated with an average length of 3.2 kb and high assembly completeness...
September 15, 2017: Genes
https://www.readbyqxmd.com/read/28891956/panax-ginseng-leaf-extracts-exert-anti-obesity-effects-in-high-fat-diet-induced-obese-rats
#17
Seul-Gi Lee, Yoon-Jeong Lee, Myeong-Hwan Jang, Tae-Ryong Kwon, Ju-Ock Nam
Recent studies have reported that the aerial parts of ginseng contain various saponins, which have anti-oxidative, anti-inflammatory, and anti-obesity properties similar to those of ginseng root. However, the leaf extracts of Korean ginseng have not yet been investigated. In this study, we demonstrate the anti-obesity effects of green leaf and dried leaf extracts (GL and DL, respectively) of ginseng in high-fat diet (HFD)-induced obese rats. The administration of GL and DL to HFD-induced obese rats significantly decreased body weight (by 96...
September 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28884396/ginsenoside-re-protects-trimethyltin-induced-neurotoxicity-via-activation-of-il-6-mediated-phosphoinositol-3-kinase-akt-signaling-in-mice
#18
Thu-Hien Thi Tu, Naveen Sharma, Eun-Joo Shin, Hai-Quyen Tran, Yu Jeung Lee, Ji Hoon Jeong, Jung Hwan Jeong, Seung Yeol Nah, Hoang-Yen Phi Tran, Jae Kyung Byun, Sung Kwon Ko, Hyoung-Chun Kim
Ginseng (Panax ginseng), an herbal medicine, has been used to prevent neurodegenerative disorders. Ginsenosides (e.g., Re, Rb1, or Rg1) were obtained from Korean mountain cultivated ginseng. The anticonvulsant activity of ginsenoside Re (20 mg/kg/day × 3) against trimethyltin (TMT) insult was the most pronounced out of ginsenosides (e.g., Re, Rb1, and Rg1). Re itself did not significantly alter tumor necrosis factor-α (TNF-α), interferon-ϒ (IFN-ϒ), and interleukin-1β (IL-1β) expression, however, it significantly increases the interleukin-6 (IL-6) expression...
November 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28844680/korean-red-ginseng-panax-ginseng-inhibits-obesity-and-improves-lipid-metabolism-in-high-fat-diet-fed-castrated-mice
#19
Soon Shik Shin, Michung Yoon
ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are strongly associated with many of the aforementioned metabolic diseases. The aim of this study was to determine the effects of ginseng on obesity and lipid metabolism in a mouse model of testosterone deficiency (castrated C57BL/6J mice)...
August 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28759009/ginseng-extract-reduces-tacrolimus-induced-oxidative-stress-by-modulating-autophagy-in-pancreatic-beta-cells
#20
COMPARATIVE STUDY
Sun Woo Lim, Long Jin, Kang Luo, Jian Jin, Chul Woo Yang
We previously reported that long-term treatment with a calcineurin inhibitor impairs autophagy process in pancreatic beta cells. This study investigated the effect of Korean red ginseng extract (KRGE) on autophagy modulated by oxidative stress. In mice with tacrolimus (Tac)-induced diabetes mellitus, KRGE alleviated islet dysfunction and decreased oxidative stress and autophagic vacuoles. In vitro, KRGE decreased autophagosome formation and attenuated lysosomal degradation, accompanied by improved beta cell viability and insulin secretion...
November 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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