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N K Lohiya, K Balasubramanian, A S Ansari
India is a home for a large variety of plants with remarkable medicinal and pharmacological value. Traditional medicine in the form of Ayurveda, Siddha and Unani has used many of these plants since ancient days for treating and curing various ailments of the body. When it comes to issues related to reproductive health, people still hesitate to discuss and/or accept it openly and hence look for alternate and natural remedies. The various tribal populations distributed across different parts of the country still use these plant extracts in various formulations for maintenance of good health...
October 2016: Andrologia
Kalaiselvi Selvaraj, Manikandan Srinivasan, Venkatachalam Duraisamy, Gomathi Ramaswamy, Vinayagamurthy Venugopal, Palanivel Chinnakali
BACKGROUND: Recently, under National Health Mission alternate systems of Medicine are mainstreamed in public health care system. Effective action plan generation, logistic arrangement and roll out of these alternate systems of Medicine needs understanding on profile of morbidities among attendees who come to these facilities. OBJECTIVES: This study was planned to report profile of morbidities, age and sex differentials in specific morbidities among geriatric attendees in secondary level siddha health facilities...
April 2016: Ancient Science of Life
Soumyajit Biswas, Rupa Shaw, Sanjay Bala, Asis Mazumdar
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal Plant resources of forest origin are extensively used in India for various systems of medicine like Ayurveda, Unani, Homeopathy, Allopathy, Siddha and Ethnic etc. The tribal communities around the Kakrajhore forest in West Medinipur district of West Bengal have their own traditional knowledge based system of curing many diseases using the forest based plant resources similar to ayurveda. The forest comprises of one of the unique treasure and rich source of diversified ethno-botanical wealth and therefore extensive studies is required for proper documentation including ethnomedicinal knowledge of local tribes...
August 30, 2016: Journal of Ethnopharmacology
K Lakshmi Josyula, Kabir Sheikh, Devaki Nambiar, Venkatesh V Narayan, T N Sathyanarayana, John D H Porter
The government of India has, over the past decade, implemented the "integration" of traditional, complementary and alternative medical (TCAM) practitioners, specifically practitioners of Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-rigpa, and Homoeopathy (collectively known by the acronym AYUSH), in government health services. A range of operational and ethical challenges has manifested during this process of large health system reform. We explored the practices and perceptions of health system actors, in relation to AYUSH providers' roles in government health services in three Indian states - Kerala, Meghalaya, and Delhi...
October 2016: Social Science & Medicine
Arokiasamy Justin Thenmozhi, Mathiyazahan Dhivyabharathi, Thamilarasan Manivasagam, Musthafa Mohamed Essa
ETHNOPHARMACOLOGICAL RELEVANCE: Fruits of Phyllanthus emblica Linn. or Emblica officinalis Gaertn. (Phyllanthaceae) are used in Ayurveda, Siddha, Unani, Arabic, Tibetan and various other folk medicinal systems to promote intelligence and memory. Recent study from our lab indicated the neuroprotective effect of tannoids principles of Emblica officinalis (EoT) against memory loss caused by aluminium chloride (AlCl3) intoxication through attenuating acetylcholine esterase activity and the expression of amyloid β protein biosynthesis related markers...
August 23, 2016: Journal of Ethnopharmacology
Chingiz Underbayev, Siddha Kasar, William Ruezinsky, Heba Degheidy, Joel Solomon Schneider, Gerald Marti, Steven R Bauer, Diego Fraidenraich, Marilyn M Lightfoote, Vijay Parashar, Elizabeth Raveche, Mona Batish
In both human chronic lymphocytic leukemia (CLL) and the New Zealand Black (NZB) murine model of CLL, decreased levels of microRNAs miR-15a/16 play an important role in the disease. Here we investigate the effects of this microRNA on early steps of B cell development and the capacity of miR-15a-deficient hematopoietic stem cells (HSC) and B1 progenitor cells (B1P) to reproduce CLL-like phenotype both in vitro and in vivo. Our results demonstrate that both miR-15a deficient HSC and B1P cells are capable of repopulating irradiated recipients and produce higher numbers of B1 cells than sources with normal miR-15a/16 levels...
August 14, 2016: Oncotarget
Lijian Yu, Haesook Kim, Siddha N Kasar, Parul Benien, Wei Du, Kevin Hoang, Andrew Aw, Bethany Tesar, Reina Improgo, Stacey Fernandes, Saranya Radhakrishnan, Josephine L Klitgaard, Charles Lee, Gad Getz, Sunita R Setlur, Jennifer R Brown
Purpose Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving event in CLL progression. We hypothesize that other concomitant genetic abnormalities underlie the clinical heterogeneity of del(17p) CLL. Experimental Design We profiled the somatic mutations and copy number alterations (CNA) in a large group of del(17p) CLL as well as wild type CLL and analyzed the genetic basis of their clinical heterogeneity...
August 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Fazlin Mohd Fauzi, Cini Mathew John, Arunkumar Karunanidhi, Hamse Y Mussa, Rajesh Ramasamy, Aishah Adam, Andreas Bender
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia auriculata (CA) is used as an antidiabetic therapy in Ayurvedic and Siddha practice. This study aimed to understand the mode-of-action of CA via combined cheminformatics and in vivo biological analysis. In particular, the effect of 10 polyphenolic constituents of CA in modulating insulin and immunoprotective pathways were studied. MATERIALS AND METHODS: In silico target prediction was first employed to predict the probability of the polyphenols interacting with key protein targets related to insulin signalling, based on a model trained on known bioactivity data and chemical similarity considerations...
July 21, 2016: Journal of Ethnopharmacology
Saravanan V Sathasivampillai, Pholtan R S Rajamanoharan, Michael Munday, Michael Heinrich
INTRODUCTION AND BACKGROUND: In recent decades diabetes mellitus has become a considerable health problem in countries like Sri Lanka and results in an increasing economic burden hampering the social and economic development of these countries. About 60 to 70 % of the rural population in Sri Lanka rely on indigenous medicinal systems as their main source for primary health care. Siddha (Tamil) Medicine is one of the four Sri Lankan traditional medicinal systems and it is practised mostly in the eastern and northern provinces of Sri Lanka where the majority of Tamils reside...
July 19, 2016: Journal of Ethnopharmacology
Vinod Kumar Joshi, Apurva Joshi, Kartar Singh Dhiman
ETHNOPHARMACOLOGICAL RELEVANCE: The Ayurvedic Pharmacopoeia of India (API) is a unique book of standards describing the quality, purity and strength of selected drugs that are manufactured, distributed, and sold by the licensed manufacturers in pan India. It is developed in two parts; the part one comprises of mono-monographs of medicinal substances of natural origin and part two includes selected compound formulations sourced from the schedule- I books under the Drugs and Cosmetics Act, 1940 comprising of popular Ayurvedic classics of different period of times...
July 9, 2016: Journal of Ethnopharmacology
Shanthi Palanivelu, Sugapriya Dhanasekeran, Haseena Banu Hedayathullah Khan, Sachdanandam Tiruvaiyaru Panchanadham
OBJECTIVE: To evaluate the protective effect of Kalpaamruthaa (KA), a modified Siddha preparation, in BCR-ABL(+) leukemic mouse model. METHODS: BCR-ABL leukemia was induced in 6-10-week-old female BALB/c mice by a single tail vein injection of the 12B1 cell line. Leukemia-induced animals were treated with KA at a dosage of 200 mg/kg body weight dissolved in 0.5 mL of olive oil for 14 days by gastrogavage. Imatinib mesylate was used as the control drug. Glycolytic, gluconeogenic, mitochondrial, tricarboxylic acid cycle and respiratory chain enzymes in the spleen and liver of mouse were compared between the control and experiment groups by biochemical assays...
June 23, 2016: Chinese Journal of Integrative Medicine
Sundararaman Swaminathan
Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in excess) and Paracelsus ("Die Dosis macht das Gift," the dose makes the poison) are of practical relevance in understanding the role of this ancient metal in acute kidney injury.
July 2016: Kidney International
Sharmistha Mallick
This paper is an attempt to understand the project of mainstreaming in India's health care system that has started with an aim to bring marginalized and alternative systems of medicine in mainstream. The project has gained much attention with the establishment of Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homeopathy (AYUSH) in the year 2003, which is now a ministry. It has ushered some positive results in terms of growth of AYUSH hospitals and dispensaries. However, it has also raised challenges around the theory and practice of mainstreaming...
March 2016: Journal of Ayurveda and Integrative Medicine
S Kannan, S Gowri
BACKGROUND: Clinical trials are mandatory for evidence-based practice. Hardly, any data are available regarding the number of clinical trials and their methodological quality that are conducted in allied fields of medicine. OBJECTIVE: The present study was envisaged to assess methodological quality of trials in allied medical fields. MATERIALS AND METHODS: Registered clinical trials in World Health Organization International Clinical Trials Registry Platform (http://apps...
March 2016: Journal of Ayurveda and Integrative Medicine
Suresh Bada Math, Sydney Moirangthem, Naveen C Kumar, Maria Christine Nirmala
Recent changes in policies allowing practitioners of Ayurveda, Yoga, Naturopathy, Unani, Siddha and Homoeopathy (AYUSH) to integrate into the mainstream of healthcare and also allowing practitioners of Ayurveda and Homoeopathy to perform medical termination of pregnancy (MTP) under the proposed amendment to the MTP bill have brought crosssystem practice into the limelight. We evaluate cross-system practice from its legal and ethical perspectives. Across judgments, the judiciary has held that cross-system practice is a form of medical negligence; however, it is permitted only in those states where the concerned governments have authorized it by a general or special order...
November 2015: National Medical Journal of India
Benjamin L Lampson, Siddha N Kasar, Tiago R Matos, Elizabeth A Morgan, Laura Rassenti, Matthew S Davids, David C Fisher, Arnold S Freedman, Caron A Jacobson, Philippe Armand, Jeremy S Abramson, Jon E Arnason, Thomas J Kipps, Joshua Fein, Stacey Fernandes, John Hanna, Jerome Ritz, Haesook T Kim, Jennifer R Brown
Idelalisib is a small-molecule inhibitor of PI3Kδ with demonstrated efficacy for the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL). To evaluate idelalisib as front-line therapy, we enrolled 24 subjects in a phase 2 study consisting of 2 months of idelalisib monotherapy followed by 6 months of combination therapy with idelalisib and the anti-CD20 antibody ofatumumab. After a median follow-up period of 14.7 months, hepatotoxicity was found to be a frequent and often severe adverse event...
July 14, 2016: Blood
(no author information available yet)
Merman E, Siddha S, Keystone JS, Al Habeeb A, Ghazarian D, Cy A, Rosen CF. Cutaneous strongyloides infection postchemotherapy. J Cutan Med Surg 2016;20:XXX-XXX. Original DOI: 10.1177/1203475416633693.
May 26, 2016: Journal of Cutaneous Medicine and Surgery
S Esakkimuthu, S Mutheeswaran, S Arvinth, M Gabriel Paulraj, P Pandikumar, S Ignacimuthu
ETHNOBOTANICAL RELEVANCE: The burden of cardiometabolic diseases such as dyslipidemia, hyperglycemia, hypertension, visceral obesity and atherosclerotic cardiovascular diseases and the use of traditional medicine for the management of such diseases are high in India; hence there is a need to document and analyze such therapies. AIM OF THE STUDY: This study documented and analyzed the medicinal plants prescribed for cardiometabolic diseases by the non-institutionally trained siddha practitioners of Tiruvallur district of Tamil Nadu, India...
June 20, 2016: Journal of Ethnopharmacology
J Arunachalam
Ayurvedic and Siddha medicinal preparations containing mercury have been used over centuries in India. The recent WHO guidelines on the use of mercurials as well as actions by other international organizations into eliminating mercury in all forms have put the people practicing Rasa Shastra in a quandary. Active research in the mechanism of curative actions of mercurials is very much essential, to have widespread acceptance of the ancient practice. The toxicity of a substance depends on its bio-availability; the chemical form in which it is present and the biochemical reactions it participates...
April 2015: Ayu
Siddha Kasar, Chingiz Underbayev, Moinuddin Hassan, Ilko Ilev, Heba Degheidy, Steven Bauer, Gerald Marti, Carol Lutz, Elizabeth Raveche, Mona Batish
New Zealand Black (NZB) mice, a de novo model of CLL, share multiple characteristics with CLL patients, including decreased expression of miR-15a/16-1. We previously discovered a point mutation and deletion in the 3' flanking region of mir-16-1 of NZB and a similar mutation has been found in a small number of CLL patients. However, it was unknown whether the mutation is the cause for the reduced miR-15a/16-1 expression and CLL development. Using PCR and in vitro microRNA processing assays, we found that the NZB sequence alterations in the mir-15a/16-1 loci result in deficient processing of the precursor forms of miR-15a/16-1, in particular, we observe impaired conversion of pri-miR-15a/16-1 to pre-miR-15a/16-1...
2016: PloS One
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