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https://www.readbyqxmd.com/read/28344029/herbasl-remedies-for-urinary-stones-used-in-india-and-china-a-review
#1
REVIEW
Deepak M Kasote, Suresh D Jagtap, Dinesh Thapa, Mahendra S Khyade, Wendy R Russell
ETHANOPHARMACOLOGICAL RELEVANCE: The process of formation or appearance of a urinary stone anywhere in the renal tract is known as urolithiasis. It is a longstanding health problem, known to exist since early age of civilization. Records about symptoms, signs and treatment strategies of urinary stones diseases are found in the several ancient texts of traditional medicines such as Ayurveda, Traditional Chinese Medicine (TCM), Siddha and Unani. In Ayurveda, urolithiasis has been considered as one of the eight most troublesome diseases...
March 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28217622/can-the-recent-public-notice-by-the-ministry-of-ayurveda-yoga-and-naturopathy-unani-siddha-and-homoeopathy-be-helpful-in-combating-the-irrational-use-of-herbal-drugs
#2
Janmejaya Samal
No abstract text is available yet for this article.
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28199309/phosphatidylinositol-3-kinase-%C3%AE-blockade-increases-genomic-instability-in-b-cells
#3
Mara Compagno, Qi Wang, Chiara Pighi, Taek-Chin Cheong, Fei-Long Meng, Teresa Poggio, Leng-Siew Yeap, Elif Karaca, Rafael B Blasco, Fernanda Langellotto, Chiara Ambrogio, Claudia Voena, Adrian Wiestner, Siddha N Kasar, Jennifer R Brown, Jing Sun, Catherine J Wu, Monica Gostissa, Frederick W Alt, Roberto Chiarle
Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation. In addition, through off-target activity, AID has a much broader effect on genomic instability by initiating oncogenic chromosomal translocations and mutations involved in the development and progression of lymphoma. AID expression is tightly regulated in B cells and its overexpression leads to enhanced genomic instability and lymphoma formation...
February 15, 2017: Nature
https://www.readbyqxmd.com/read/28182033/preliminary-screening-of-a-classical-ayurvedic-formulation-for-anticonvulsant-activity
#4
Arnab Dhar, Santosh Kumar Maurya, Ashish Mishra, Gireesh Kumar Singh, Manoj Kumar Singh, Ankit Seth
BACKGROUND: Epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmitters level in the brain. The available treatments are neither competent to control the seizures nor prevent progress of disease. Since ages, Herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional systems of medicine i...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28163968/antioxidant-activity-phenolic-flavonoid-content-and-high-performance-liquid-chromatography-profiling-of-three-different-variants-of-syzygium-cumini-seeds-a-comparative-study
#5
Syama Hari Priya, Nisha Prakasan, Jayamurthy Purushothaman
BACKGROUND: The medicinally important phytochemicals present in Syzygium cumini seeds probably accounts for its wide use in traditional systems of medicines in India, like Ayurveda, Unani, and Siddha. AIM: The aim of the study was to determine the antioxidant potential of three different geographical variants of S. cumini seeds and to compare the phenolic profiling to know the effect of geographical variation in phenolic composition. MATERIALS AND METHODS: Total phenolic and flavonoid content of S...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28095356/a-systems-pharmacology-perspective-to-decipher-the-mechanism-of-action-of-parangichakkai-chooranam-a-siddha-formulation-for-the-treatment-of-psoriasis
#6
Sudharsana Sundarrajan, Mohanapriya Arumugam
Psoriasis is a chronic relapsing immune mediated disorder of the skin. The disease presents itself with well featured clinical and histological characteristics however the aetiology of the disease still remains obscure. The current systemic therapies aim to eliminate the symptoms of disease rather than offering a complete cure. Parangichakkai chooranam (PC), a Siddha oral herbal formulation has been widely prescribed for the treatment of psoriasis. Though the medication is highly prescribed by the Siddha healers the mechanism of PC for the treatment of psoriasis remains to be elucidated...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068637/assembling-of-multifunctional-latex-based-hybrid-nanocarriers-from-calotropis-gigantea-for-sustained-doxorubicin-dox-releases
#7
Periyakaruppan Pradeepkumar, Dharman Govindaraj, Murugaraj Jeyaraj, Murugan A Munusamy, Mariappan Rajan
Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27774418/nephroprotective-effect-of-ethanolic-extract-of-azima-tetracantha-root-in-glycerol-induced-acute-renal-failure-in-wistar-albino-rats
#8
Venugopala Rao Konda, Ruckmani Arunachalam, Madhavi Eerike, Ramesh Rao K, Arun Kumar Radhakrishnan, Lakshmipathy Prabhu Raghuraman, Vinayak Meti, Sobita Devi
The gravity of the impact of renal failure on human health is well known and as there is no specific pharmacotherapy for renal failure, the current study was undertaken to evaluate the effect of root extract of Azima tetracantha, an ancient medicinal plant used in Siddha and Ayurvedhic systems of medicine. The experiment was done in glycerol-induced acute renal failure in Wistar albino rats. Thirty rats were divided into five groups. Group 1 was given normal saline (10 ml/kg) per oral, group 2 with single dose of hypertonic glycerol (8 ml/kg) by intramuscular injection into the hind limbs, group 3 with glycerol and ethanolic extract of A...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27681646/indian-folklore-medicine-in-managing-men-s-health-and-wellness
#9
REVIEW
N K Lohiya, K Balasubramanian, A S Ansari
India is a home for a large variety of plants with remarkable medicinal and pharmacological value. Traditional medicine in the form of Ayurveda, Siddha and Unani has used many of these plants since ancient days for treating and curing various ailments of the body. When it comes to issues related to reproductive health, people still hesitate to discuss and/or accept it openly and hence look for alternate and natural remedies. The various tribal populations distributed across different parts of the country still use these plant extracts in various formulations for maintenance of good health...
October 2016: Andrologia
https://www.readbyqxmd.com/read/27621518/morbidity-profile-of-elderly-outpatients-attending-selected-sub-district-siddha-health-facilities-in-tamil-nadu-india
#10
Kalaiselvi Selvaraj, Manikandan Srinivasan, Venkatachalam Duraisamy, Gomathi Ramaswamy, Vinayagamurthy Venugopal, Palanivel Chinnakali
BACKGROUND: Recently, under National Health Mission alternate systems of Medicine are mainstreamed in public health care system. Effective action plan generation, logistic arrangement and roll out of these alternate systems of Medicine needs understanding on profile of morbidities among attendees who come to these facilities. OBJECTIVES: This study was planned to report profile of morbidities, age and sex differentials in specific morbidities among geriatric attendees in secondary level siddha health facilities...
April 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27590732/inventorization-of-some-ayurvedic-plants-and-their-ethnomedicinal-use-in-kakrajhore-forest-area-of-west-bengal
#11
Soumyajit Biswas, Rupa Shaw, Sanjay Bala, Asis Mazumdar
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal Plant resources of forest origin are extensively used in India for various systems of medicine like Ayurveda, Unani, Homeopathy, Allopathy, Siddha and Ethnic etc. The tribal communities around the Kakrajhore forest in West Medinipur district of West Bengal have their own traditional knowledge based system of curing many diseases using the forest based plant resources similar to ayurveda. The forest comprises of one of the unique treasure and rich source of diversified ethno-botanical wealth and therefore extensive studies is required for proper documentation including ethnomedicinal knowledge of local tribes...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27575933/-getting-the-water-carrier-to-light-the-lamps-discrepant-role-perceptions-of-traditional-complementary-and-alternative-medical-practitioners-in-government-health-facilities-in-india
#12
K Lakshmi Josyula, Kabir Sheikh, Devaki Nambiar, Venkatesh V Narayan, T N Sathyanarayana, John D H Porter
The government of India has, over the past decade, implemented the "integration" of traditional, complementary and alternative medical (TCAM) practitioners, specifically practitioners of Ayurveda, Yoga and Naturopathy, Unani, Siddha, Sowa-rigpa, and Homoeopathy (collectively known by the acronym AYUSH), in government health services. A range of operational and ethical challenges has manifested during this process of large health system reform. We explored the practices and perceptions of health system actors, in relation to AYUSH providers' roles in government health services in three Indian states - Kerala, Meghalaya, and Delhi...
October 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27566203/tannoid-principles-of-emblica-officinalis-attenuated-aluminum-chloride-induced-apoptosis-by-suppressing-oxidative-stress-and-tau-pathology-via-akt-gsk-3%C3%AE-signaling-pathway
#13
Arokiasamy Justin Thenmozhi, Mathiyazahan Dhivyabharathi, Thamilarasan Manivasagam, Musthafa Mohamed Essa
ETHNOPHARMACOLOGICAL RELEVANCE: Fruits of Phyllanthus emblica Linn. or Emblica officinalis Gaertn. (Phyllanthaceae) are used in Ayurveda, Siddha, Unani, Arabic, Tibetan and various other folk medicinal systems to promote intelligence and memory. Recent study from our lab indicated the neuroprotective effect of tannoids principles of Emblica officinalis (EoT) against memory loss caused by aluminum chloride (AlCl3) intoxication through attenuating acetylcholine esterase activity and the expression of amyloid β protein biosynthesis related markers...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27533467/role-of-mir-15a-16-1-in-early-b-cell-development-in-a-mouse-model-of-chronic-lymphocytic-leukemia
#14
Chingiz Underbayev, Siddha Kasar, William Ruezinsky, Heba Degheidy, Joel Solomon Schneider, Gerald Marti, Steven R Bauer, Diego Fraidenraich, Marilyn M Lightfoote, Vijay Parashar, Elizabeth Raveche, Mona Batish
In both human chronic lymphocytic leukemia (CLL) and the New Zealand Black (NZB) murine model of CLL, decreased levels of microRNAs miR-15a/16 play an important role in the disease. Here we investigate the effects of this microRNA on early steps of B cell development and the capacity of miR-15a-deficient hematopoietic stem cells (HSC) and B1 progenitor cells (B1P) to reproduce CLL-like phenotype both in vitro and in vivo. Our results demonstrate that both miR-15a deficient HSC and B1P cells are capable of repopulating irradiated recipients and produce higher numbers of B1 cells than sources with normal miR-15a/16 levels...
September 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27503198/survival-of-del17p-cll-depends-on-genomic-complexity-and-somatic-mutation
#15
Lijian Yu, Haesook T Kim, Siddha N Kasar, Parul Benien, Wei Du, Kevin Hoang, Andrew Aw, Bethany Tesar, Reina Improgo, Stacey M Fernandes, Saranya Radhakrishnan, Josephine L Klitgaard, Charles Lee, Gad Getz, Sunita R Setlur, Jennifer R Brown
PURPOSE: Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving event in CLL progression. We hypothesize that other concomitant genetic abnormalities underlie the clinical heterogeneity of del(17p) CLL. EXPERIMENTAL DESIGN: We profiled the somatic mutations and copy number alterations (CNA) in a large group of del(17p) CLLs as well as wild-type CLL and analyzed the genetic basis of their clinical heterogeneity...
August 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27452659/understanding-the-mode-of-action-of-cassia-auriculata-via-in-silico-and-in-vivo-studies-towards-validating-it-as-a-long-term-therapy-for-type-ii-diabetes
#16
Fazlin Mohd Fauzi, Cini Mathew John, Arunkumar Karunanidhi, Hamse Y Mussa, Rajesh Ramasamy, Aishah Adam, Andreas Bender
ETHNOPHARMACOLOGICAL RELEVANCE: Cassia auriculata (CA) is used as an antidiabetic therapy in Ayurvedic and Siddha practice. This study aimed to understand the mode-of-action of CA via combined cheminformatics and in vivo biological analysis. In particular, the effect of 10 polyphenolic constituents of CA in modulating insulin and immunoprotective pathways were studied. MATERIALS AND METHODS: In silico target prediction was first employed to predict the probability of the polyphenols interacting with key protein targets related to insulin signalling, based on a model trained on known bioactivity data and chemical similarity considerations...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27448453/plants-used-to-treat-diabetes-in-sri-lankan-siddha-medicine-an-ethnopharmacological-review-of-historical-and-modern-sources
#17
REVIEW
Saravanan V Sathasivampillai, Pholtan R S Rajamanoharan, Michael Munday, Michael Heinrich
INTRODUCTION AND BACKGROUND: In recent decades diabetes mellitus has become a considerable health problem in countries like Sri Lanka and results in an increasing economic burden hampering the social and economic development of these countries. About 60% to 70% of the rural population in Sri Lanka rely on indigenous medicinal systems as their main source for primary health care. Siddha (Tamil) Medicine is one of the four Sri Lankan traditional medicinal systems and it is practised mostly in the eastern and northern provinces of Sri Lanka where the majority of Tamils reside...
July 19, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27404231/the-ayurvedic-pharmacopoeia-of-india-development-and-perspectives
#18
Vinod Kumar Joshi, Apurva Joshi, Kartar Singh Dhiman
ETHNOPHARMACOLOGICAL RELEVANCE: The Ayurvedic Pharmacopoeia of India (API) is a unique book of standards describing the quality, purity and strength of selected drugs that are manufactured, distributed, and sold by the licensed manufacturers in pan India. It is developed in two parts; the part one comprises of mono-monographs of medicinal substances of natural origin and part two includes selected compound formulations sourced from the schedule - I books under the Drugs and Cosmetics Act, 1940 comprising of popular Ayurvedic classics of different period of times...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27338823/ameliorating-effect-of-kalpaamruthaa-on-altered-energy-metabolism-in-bcr-abl-cell-line-induced-leukemic-mouse-model
#19
Shanthi Palanivelu, Sugapriya Dhanasekeran, Haseena Banu Hedayathullah Khan, Sachdanandam Tiruvaiyaru Panchanadham
OBJECTIVE: To evaluate the protective effect of Kalpaamruthaa (KA), a modified Siddha preparation, in BCR-ABL(+) leukemic mouse model. METHODS: BCR-ABL leukemia was induced in 6-10-week-old female BALB/c mice by a single tail vein injection of the 12B1 cell line. Leukemia-induced animals were treated with KA at a dosage of 200 mg/kg body weight dissolved in 0.5 mL of olive oil for 14 days by gastrogavage. Imatinib mesylate was used as the control drug. Glycolytic, gluconeogenic, mitochondrial, tricarboxylic acid cycle and respiratory chain enzymes in the spleen and liver of mouse were compared between the control and experiment groups by biochemical assays...
June 23, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27312440/iron-hormesis-and-protection-in-acute-kidney-injury
#20
Sundararaman Swaminathan
Iron is critical for cellular, organismal, and possibly universal existence. Use of iron complexes to treat human diseases is ancient and is described in detail in Ayurveda/Siddha systems of medicine. Old aphorisms from Siddha medicine ("Alavukku Minjinal Amirdhamum Nanjagum," an elixir turns poisonous when taken in excess) and Paracelsus ("Die Dosis macht das Gift," the dose makes the poison) are of practical relevance in understanding the role of this ancient metal in acute kidney injury.
July 2016: Kidney International
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