Nara Lins Meira Quintão, Jaqueline Pavesi Reis, Larissa Benvenutti, Roberta Nunes, Fernanda Capitanio Goldoni, Manuela Somensi Cozer, Priscila de Souza, Rita de Cássia Melo Vilhena de Andrade Fonseca da Silva, Jessica Melato, Carlos Rafael Vaz, Juliana Cristina Pereira Whitaker, Flavia Werner Jesuíno, Mariana Couto Costa, Maria Verônica Dávila Pastor, Angela Malheiros, Christiane Meyre-Silva, José Roberto Santin
The effects of Piper malacophyllum (C. Pesl) C. DC extracts and its isolated compounds were analysed in a mouse model of primary dysmenorrhoea (PD). Female Swiss mice (6-8 weeks old) on proestrus were intraperitoneally treated with estradiol benzoate for 3 days, to induce PD. Twenty-four hours later, animals were treated 24 h later with vehicle, plant extract, gibbilimbol B, 4,6-dimethoxy-5-E-phenylbutenolide, mixture of 4,6-dimethoxy-5-E-phenylbutenolide and 4,6-dimethoxy-5-Z-phenylbutenolide, or ibuprofen...
July 22, 2022: Inflammopharmacology