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https://www.readbyqxmd.com/read/27899300/role-of-the-endocannabinoid-system-in-the-control-of-mouse-myometrium-contractility-during-the-menstrual-cycle
#1
Ester Pagano, Pierangelo Orlando, Stefania Finizio, Antonietta Rossi, Lorena Buono, Fabio Arturo Iannotti, Fabiana Piscitelli, Angelo A Izzo, Vincenzo Di Marzo, Francesca Borrelli
Cannabis and cannabinoids are known to affect female reproduction. However, the role of the endocannabinoid system in mouse uterine contractility in the dioestrus and oestrus phases has not been previously investigated. The present study aimed at filling this gap. Endocannabinoid (anandamide and 2-arachidonoylglycerol) levels were measured in mouse uterus at dioestrus and oestrus phases by liquid chromatography-mass spectrometry; quantitative reverse transcription-PCR measured mRNA expression of cannabinoid receptors and enzymes involved in the metabolism of endocannabinoids...
November 26, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27898948/%C3%AE-and-%C3%AE-adrenergic-receptors-stimulation-relaxes-porcine-myometrium-in-the-peri-implantation-period
#2
W Markiewicz, J J Jaroszewski
These studies were to demonstrate whether the β-receptor is involved in regulating the contractility of the swine myometrium in the peri-implantation period and to compare a relaxing activity of selective β- and β-adrenergic agonists (salbutamol and BRL 37344, respectively). Myometrial strips were collected form the gilts ( = 8) on d 12 to 14 of pregnancy. Changes in the contractility of myometrial strips were assessed further to the administration of increasing concentrations of the agonists (10 to 10 ) with and without β-adrenergic receptor antagonists: butoxamine, propranolol, and bupranolol at 10 ...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27798640/altered-expression-of-human-smooth-muscle-myosin-phosphatase-targeting-mypt-isovariants-with-pregnancy-and-labor
#3
Jon Lartey, Julie Taggart, Stephen Robson, Michael Taggart
BACKGROUND: Myosin light-chain phosphatase is a trimeric protein that hydrolyses phosphorylated myosin II light chains (MYLII) to cause relaxation in smooth muscle cells including those of the uterus. A major component of the phosphatase is the myosin targeting subunit (MYPT), which directs a catalytic subunit to dephosphorylate MYLII. There are 5 main MYPT family members (MYPT1 (PPP1R12A), MYPT2 (PPP1R12B), MYPT3 (PPP1R16A), myosin binding subunit 85 MBS85 (PPP1R12C) and TIMAP (TGF-beta-inhibited membrane-associated protein (PPP1R16B))...
2016: PloS One
https://www.readbyqxmd.com/read/27782742/short-term-administration-of-melatonin-or-ghrelin-on-diabetic-rats-effects-on-angiotensin-ii-and-vasopressin-induced-uterine-contractility
#4
T Georgiev, A Tolekova, R Kalfin, P Hadzhibozheva
The aim of the present study was to investigate the effects of Angiotensin II (AngII) and Arginin-Vasopressin (AVP) on contractility of non-pregnant uterus in diabetic Wistar rats and to explore whether one-week administration of Melatonin (MLT) or Ghrelin (GHR) will change the response of diabetic uterine muscle to AngII and AVP. Uterine horns, prepared by the method of isolated tissues were investigated as well as glycemic profile, blood pressure and body weight. The research of smooth muscle contractions was made by a new method of analysis, characterizing in detail the various phases of the myometrial activity...
October 26, 2016: Physiological Research
https://www.readbyqxmd.com/read/27739411/inhibition-of-uterine-contractility-by-thalidomide-analogs-via-phosphodiesterase-4-inhibition-and-calcium-entry-blockade
#5
Eduardo Fernández-Martínez, Héctor Ponce-Monter, Luis E Soria-Jasso, Mario I Ortiz, José-Antonio Arias-Montaño, Guillermo Barragán-Ramírez, Cynthia Mayén-García
Uterine relaxation is crucial during preterm labor. Phosphodiesterase-4 (PDE-4) inhibitors have been proposed as tocolytics. Some thalidomide analogs are PDE-4 inhibitors. The aim of this study was to assess the uterus-relaxant properties of two thalidomide analogs, methyl 3-(4-nitrophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate (4NO2PDPMe) and methyl 3-(4-aminophthalimido)-3-(3,4-dimethoxyphenyl)-propanoate (4APDPMe) and were compared to rolipram in functional studies of spontaneous phasic, K⁺-induced tonic, and Ca(2+)-induced contractions in isolated pregnant human myometrial tissues...
October 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27690099/ex-vivo-smooth-muscle-pharmacological-effects-of-a-novel-bradykinin-related-peptide-and-its-analogue-from-chinese-large-odorous-frog-odorrana-livida-skin-secretions
#6
Jie Xiang, Hui Wang, Chengbang Ma, Mei Zhou, Yuxin Wu, Lei Wang, Shaodong Guo, Tianbao Chen, Chris Shaw
Bradykinin-related peptides (BRPs) are one of the most extensively studied frog secretions-derived peptide families identified from many amphibian species. The diverse primary structures of BRPs have been proven essential for providing valuable information in understanding basic mechanisms associated with drug modification. Here, we isolated, identified and characterized a dodeca-BRP (RAP-L1, T6-BK), with primary structure RAPLPPGFTPFR, from the skin secretions of Chinese large odorous frogs, Odorrana livida...
2016: Toxins
https://www.readbyqxmd.com/read/27648097/association-of-helicobacter-pylori-infection-and-ectopic-pregnancy
#7
Fariba Nanbakhsh, Tahereh Behrouzi-Lak, Mahsa Tabean, Sima Oshnouei, Pooya Mazlumi
OBJECTIVE: To evaluate the importance of cytokine type in embryo implantation in uterus specified and activated macrophages interfere the tube movements and embryo retention in uterine tubes by smooth muscle relaxation and disrupting ciliary function. Therefore, increased risk of infection with HP during pregnancy, we investigated relation between Helicobacter pylori (HP) infection and prevalence of ectopic pregnancy (EP) in this study. MATERIALS AND METHODS: This is cross-sectional study from March 2012 to May 2013...
June 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/27610042/myometrial-relaxation-of-mice-via-expression-of-two-pore-domain-acid-sensitive-k-task-2-channels
#8
Kyu-Sang Kyeong, Seung Hwa Hong, Young Chul Kim, Woong Cho, Sun Chul Myung, Moo Yeol Lee, Ra Young You, Chan Hyung Kim, So Yeon Kwon, Hikaru Suzuki, Yeon Jin Park, Eun-Hwan Jeong, Hak Soon Kim, Heon Kim, Seung Woon Lim, Wen-Xie Xu, Sang Jin Lee, Il Woon Ji
Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K(+) channels (TASK-2) might be one of the candidates for the regulation of uterine circular smooth muscles in mice. In this study, we tried to show the mechanisms of relaxation via TASK-2 channels in marine myometrium. Isometric contraction measurements and patch clamp technique were used to verify TASK conductance in murine myometrium...
September 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27543267/a-dynamical-systems-model-of-progesterone-receptor-interactions-with-inflammation-in-human-parturition
#9
Douglas Brubaker, Alethea Barbaro, Mark R Chance, Sam Mesiano
BACKGROUND: Progesterone promotes uterine relaxation and is essential for the maintenance of pregnancy. Withdrawal of progesterone activity and increased inflammation within the uterine tissues are key triggers for parturition. Progesterone actions in myometrial cells are mediated by two progesterone receptor (PR) isoforms, PR-A and PR-B, that function as ligand-activated transcription factors. PR-B mediates relaxatory actions of progesterone, in part, by decreasing myometrial cell responsiveness to pro-inflammatory stimuli...
2016: BMC Systems Biology
https://www.readbyqxmd.com/read/27437313/chronic-uterine-inversion-presenting-as-a-painless-vaginal-mass-at-6-months-post-partum-a-case-report
#10
Eram Ali, Manisha Kumar
Uterine inversion is an abnormal protrusion of internal surface of relaxed uterus through the vaginal orifice. Its causes can be broadly classified as puerperal and non-puerperal with puerperal uterine inversion more common than non-puerperal uterine inversion. Acute inversions occurring immediately, or within 24 hours post-partum are the most common type. Chronic Uterine Inversions (CUI) occurring more than four weeks after the delivery are rare identities. There differential diagnosis includes prolapsed fibroids and endometrial polyp...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27396394/a-systematic-review-of-the-uterine-relaxant-effect-of-herbal-sources
#11
REVIEW
Golnaz Rezaeizadeh, Sedigheh Hantoushzadeh, Sima Ghiasi, Shekoufeh Nikfar, Mohammad Abdollahi
BACKGROUND: Preterm birth is a worldwide tragedy with a high incidence. Several medications are used to inhibit acute preterm labor, but tocolysis by these medicines do not extend pregnancy beyond 1-2 days. OBJECTIVES: The purpose of this study was to discover new medications from plant extracts or their active compounds which inhibit the uterine contractions in order to treat preterm labor. DATA SOURCES: PubMed, Google Scholar, Scopus and IranMedex databases were searched up to 1st February 2012 with the most relevant keywords...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27340106/traditional-chinese-medicine-guizhi-fuling-capsule-used-for-therapy-of-dysmenorrhea-via-attenuating-uterus-contraction
#12
Lan Sun, Lina Liu, Shaobo Zong, Zhengzhong Wang, Jun Zhou, Zhiliang Xu, Gang Ding, Wei Xiao, Junping Kou
ETHNOPHARMACOLOGICAL RELEVANCE: Guizhi Fuling formula, a well-known Chinese herbal formula recorded in the Eastern Han Dynasty, is composed of Cinnamomum cassia (L.) J.Presl (Cassia bark), Poria cocos (Schw.) Wolf (Poria), Paeonia suffruticosa andrews (Moutan Cortex), Paeonia lactiflora Pall (Herbaceous peony), and Amygdalus persica L.(Persicae Semen). It has clinical efficacy of activating blood circulation to dissipate blood stasis and is commonly used for the treatment of primary dysmenorrhea...
September 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27326921/l-cys-cse-h2s-pathway-modulates-mouse-uterus-motility-and-sildenafil-effect
#13
Emma Mitidieri, Teresa Tramontano, Erminia Donnarumma, Vincenzo Brancaleone, Giuseppe Cirino, Roberta d'Emmanuele di Villa Bianca, Raffaella Sorrentino
Sildenafil, a selective phosphodiesterase type 5 (PDE5) inhibitor, commonly used in the oral treatment for erectile dysfunction, relaxes smooth muscle of human bladder through the activation of hydrogen sulfide (H2S) signaling. H2S is an endogenous gaseous transmitter with myorelaxant properties predominantly formed from l-cysteine (l-Cys) by cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE). Sildenafil also relaxes rat and human myometrium during preterm labor but the underlying mechanism is still unclear...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27164925/functional-involvement-of-l-type-calcium-channels-and-cyclic-nucleotide-dependent-pathways-in-cadmium-induced-myometrial-relaxation-in-rats
#14
V K Saroj, U P Nakade, A Sharma, R S Yadav, S W Hajare, S K Garg
Modulation of myometrial spontaneity by cadmium (Cd) and its regulatory pathways was studied in rat uterus in the absence and presence of blockers of different signaling pathways. Isometric tension in myometrial strips, under a resting tension of 1 g, mounted in organ bath containing Ringer-Locke solution (RLS) continuously aerated with carbogen, was measured using data acquisition system-based physiograph and Lab Chart Pro V7.3.7 software. Mean integral tension was measured for 8 min. Cd (1 nM-0.1 mM) not only produced concentration-dependent inhibitory effect on rat myometrium but it (10 µM) also significantly (p < 0...
May 10, 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/27132415/effects-of-piroxicam-administration-on-pregnancy-outcome-in-intrauterine-insemination-iui-cycles-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
A Zarei, M Mahboubi, M E Parsanezhad, S Alborzi, M Younesi, G Madadi
BACKGROUND: Uterus contractibility is considered a powerful prognostic factor in predicting the embryo transfer outcome. Moreover, uterine contractions are known to be stimulated by prostaglandins which are produced by cyclooxygenase from arachidonic acid. As such, suppressing the inflammatory response and contractions using anti-inflammatory and relaxant agents is expected to result in increased success rate of embryo transfer and artificial insemination. OBJECTIVE: To investigate the effect of piroxicam administration on the success rate in intrauterine insemination (IU) cycles in patients presenting with unexplained infertility...
2016: Clinical and Experimental Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27109906/a-systematic-review-of-the-uterine-relaxant-effect-of-herbal-sources
#16
Golnaz Rezaeizadeh, Sedigheh Hantoushzadeh, Sima Ghiasi, Shekoufeh Nikfar, Mohammad Abdollahi
BACKGROUND: Preterm birth is a worldwide tragedy with a high incidence. Several medications are used to inhibit acute preterm labor, but tocolysis by these medicines do not extend pregnancy beyond 1-2 days. OBJECTIVES: The purpose of this study was to discover new medications from plant extracts or their active compounds which inhibit the uterine contractions in order to treat preterm labor. DATA SOURCES: PubMed, Google Scholar, Scopus and IranMedex databases were searched up to 1st February 2012 with the most relevant keywords...
April 25, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/26968678/ge-gen-decoction-attenuates-oxytocin-induced-uterine-contraction-and-writhing-response-potential-application-in-primary-dysmenorrhea-therapy
#17
Lu Yang, Cheng-Zhi Chai, Xin-Yi Yue, Yan Yan, Jun-Ping Kou, Zheng-Yu Cao, Bo-Yang Yu
The uterine tetanic contraction and uterine artery blood flow reduction are possible reasons for primary dysmenorrhea (PD). In the present study, we aimed to evaluate the uterine relaxant effect and the influence on uterine artery blood velocity of Ge-Gen Decoction (GGD), a well-known Chinese herbal formula. In female ICR mice, uterine contraction was induced by oxytocin exposure following estradiol benzoate pretreatment, and the uterine artery blood velocity was detected by Doppler ultrasound. Histopathological examination of the uterine tissue samples were performed by H&E staining...
February 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/26827159/techniques-for-assisting-difficult-delivery-at-caesarean-section
#18
REVIEW
Heather Waterfall, Rosalie M Grivell, Jodie M Dodd
BACKGROUND: Caesarean section involves making an incision in the woman's abdomen and cutting through the uterine muscle. The baby is then delivered through that incision. Difficult caesarean birth may result in injury for the infant or complications for the mother. Methods to assist with delivery include vacuum or forceps extraction or manual delivery utilising fundal pressure. Medication that relaxes the uterus (tocolytic medication) may facilitate the birth of the baby at caesarean section...
January 31, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26607809/mr-imaging-of-fetuses-to-evaluate-placental-insufficiency
#19
Yoshimitsu Ohgiya, Hiroshi Nobusawa, Noritaka Seino, Osamu Miyagami, Naomi Yagi, Sasamori Hiroto, Jiro Munechika, Masanori Hirose, Nobuyuki Takeyama, Nobuyuki Ohike, Ryu Matsuoka, Akihiko Sekizawa, Takehiko Gokan
PURPOSE: To evaluate morphological and signal intensity (SI) changes of placental insufficiency on magnetic resonance imaging (MRI) and to assess morphological changes and decreased flow voids (FVs) on T2-weighted rapid acquisition with relaxation enhancement (RARE) images for diagnosing placental insufficiency. METHODS: Fifty singleton fetuses underwent MRI using a 1.5-T MR scanner. Placental thickness, area, volume, SI, amniotic fluid SI, and size of FVs between the uterus and the placenta were measured on MR images...
2016: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/26586278/effects-on-the-equine-endometrium-of-cervical-occlusion-after-insemination
#20
Tiina Reilas, Maria Montserrat Rivera Del Alamo, Evija Liepina, Marc Yeste, Terttu Katila
Cervical patency is considered to be important for uterine drainage after mating or artificial insemination (AI), and failure to relax or premature tightening of the cervix can lead to persistent endometritis. This study investigated the hypothesis that cervical occlusion after AI increases accumulation of fluid, polymorphonuclear leukocytes (PMNs), and cytokines in the uterine lumen. Endometrial swabs were obtained from 29 normal cyclic mares during the first, third, and fifth estrus and biopsies during the first and fifth estrus...
March 1, 2016: Theriogenology
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