Esther Pilar García-Santos, María del Carmen Manzanares-Campillo, David Padilla-Valverde, Pedro Villarejo-Campos, Aurora Gil-Rendo, Virginia Muñoz-Atienza, Susana Sánchez-García, Ana María Puig-Rullán, José Luis Rodríguez-Peralto, Jesús Martín-Fernández
INTRODUCTION: Nesidioblastosis is a rare disease caused by hyperplasia of pancreatic islets, developing a state of hypoglycemia due to an increase in the insulin production. It is the leading cause of hyperinsulinic hypoglycemia in childhood, whereas in adults it only represents the 0.5-5% of cases. The pathogenesis is still unknown. We have studied several genetic mutations associated with dependent potassium channel of ATP present in the beta cells of the pancreas, as well as in patients underwent bariatric surgery because of the metabolic changes involved...
September 2013: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]