Xiaoyue Zhang, Zhengshuo Li, Qiu Peng, Can Liu, Yangge Wu, Yuqing Wen, Run Zheng, Chenxiao Xu, Junrui Tian, Xiang Zheng, Qun Yan, Jia Wang, Jian Ma
Epstein-Barr virus (EBV) is a human tumor virus associated with a variety of malignancies, including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas. N6 -methyladenosine (m6 A) modifications modulate a wide range of cellular processes and participate in the regulation of virus-host cell interactions. Here, we discovered that EBV infection downregulates Toll-like receptor 9 (TLR9) m6 A modification levels and thus inhibits TLR9 expression. TLR9 has multiple m6 A modification sites. Knockdown of METTL3, an m6 A "writer", decreases TLR9 protein expression by inhibiting its mRNA stability...
March 25, 2024: Journal of Biological Chemistry