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Toshihiro Mita, Richard Culleton, Nobuyuki Takahashi, Masatoshi Nakamura, Takahiro Tsukahara, Carol W Hunja, Zin Zayar Win, Wah Win Htike, Aung S Marma, Lek Dysoley, Mathieu Ndounga, Mawuli Dzodzomenyo, Willis S Akhwale, Jun Kobayashi, Haruki Uemura, Akira Kaneko, Francis Hombhanje, Marcelo U Ferreira, Anders Björkman, Hiroyoshi Endo, Jun Ohashi
The emergence and spread of artemisinin-resistant Plasmodium falciparum is of huge concern for the global effort toward malaria control and elimination. Artemisinin resistance, defined as a delayed time to parasite clearance following administration of artemisinin, is associated with mutations in the Pfkelch13 gene of resistant parasites. To date, as many as 60 nonsynonymous mutations have been identified in this gene, but whether these mutations have been selected by artemisinin usage or merely reflect natural polymorphism independent of selection is currently unknown...
June 2016: Antimicrobial Agents and Chemotherapy
Amanda K Marma, Alexander R Opotowsky, Brian S Fromm, Ana Ubeda-Tikkanen, Diego Porras, Jonathan Rhodes
BACKGROUND: Inert gas rebreathing (IGR) techniques provide rapid, reliable estimates of cardiac output in adults with structurally normal hearts. Data on IGR reliability in pediatric and congenital heart disease populations are lacking. Our objective was to validate pulmonary blood flow (Qp) measurement by IGR compared with clinical reference tests, cardiovascular magnetic resonance (CMR), and indirect Fick. METHODS: Pulmonary blood flow was measured by IGR and CMR or indirect Fick in 80 patients grouped by presence and type of shunt lesion...
April 2016: American Heart Journal
Kerry L Shannon, Sabeena Ahmed, Hafizur Rahman, Chai S Prue, Jacob Khyang, Malathi Ram, M Zahirul Haq, Ashish Chowdhury, Jasmin Akter, Gregory E Glass, Timothy Shields, Myaing M Nyunt, Wasif A Khan, David A Sack, David J Sullivan
Hemoglobin E is largely confined to south and southeast Asia. The association between hemoglobin E (HbE) and malaria is less clear than that of hemoglobin S and C. As part of a malaria study in the Chittagong Hill Districts of Bangladesh, an initial random sample of 202 individuals showed that 39% and 49% of Marma and Khyang ethnic groups, respectively, were positive for either heterozygous or homozygous hemoglobin E. In this group, 6.4% were also found to be severely deficient and 35% mildly deficient for glucose-6-phosphate dehydrogenase (G6PD)...
August 2015: American Journal of Tropical Medicine and Hygiene
Tafsina Haque Aurin, Saurab Kishore Munshi, S M Mostofa Kamal, Md Mostafizur Rahman, Md Shamim Hossain, Thaythayhla Marma, Farjana Rahman, Rashed Noor
The principal obstacles in the treatment of tuberculosis (TB) are delayed and inaccurate diagnosis which often leads to the onset of the drug resistant TB cases. To avail the appropriate treatment of the patients and to hinder the transmission of drug-resistant TB, accurate and rapid detection of resistant isolates is critical. Present study was designed to demonstrate the efficacy of molecular techniques inclusive of line probe assay (LPA) and GeneXpert MTB/RIF methods for the detection of multi-drug resistant (MDR) TB...
2014: PloS One
P Oscarson, B Ingemarsson, M Af Ugglas, C M Larsson
Influx, efflux and net uptake of NO 3 (-) was studied in Pisum sativum L. cv. Marma in short-term experiments where (13)NO 3 (-) was used to trace influx. The influx rate in N-limited plants was similar both during net uptake at external concentrations of around 50 μM, and at low external NO 3 (-) concentrations (4-6 μM) when net uptake was practically zero. Efflux could be inferred from discrepancies between influx and net uptake but was never very high in the N-limited plants during net uptake. Close to the threshold concentration for not NO 3 (-) uptake, efflux was high and equalled influx...
April 1987: Planta
Nurun Nahar Gazi, Rakesh Tamang, Vipin Kumar Singh, Ahmed Ferdous, Ajai Kumar Pathak, Mugdha Singh, Sharath Anugula, Pandichelvam Veeraiah, Subburaj Kadarkaraisamy, Brijesh Kumar Yadav, Alla G Reddy, Deepa Selvi Rani, Syed Saleheen Qadri, Lalji Singh, Gyaneshwer Chaubey, Kumarasamy Thangaraj
Human settlement and migrations along sides of Bay-of-Bengal have played a vital role in shaping the genetic landscape of Bangladesh, Eastern India and Southeast Asia. Bangladesh and Northeast India form the vital land bridge between the South and Southeast Asia. To reconstruct the population history of this region and to see whether this diverse region geographically acted as a corridor or barrier for human interaction between South Asia and Southeast Asia, we, for the first time analyzed high resolution uniparental (mtDNA and Y chromosome) and biparental autosomal genetic markers among aboriginal Bangladesh tribes currently speaking Tibeto-Burman language...
2013: PloS One
Toshihiro Mita, Jun Ohashi, Meera Venkatesan, Aung Swi Prue Marma, Masatoshi Nakamura, Christopher V Plowe, Kazuyuki Tanabe
BACKGROUND: Monitoring the prevalence of drug resistant Plasmodium falciparum is essential for effective malaria control. Resistance to pyrimethamine and sulfadoxine increases as mutations accumulate in the parasite genes encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps), respectively. Although parasites are exposed to these antifolate drugs simultaneously, it remains virtually unknown whether dhfr and dhps mutations accumulate along interrelated paths. METHODS: We investigated the order of step-wise accumulation in dhfr and dhps by cumulative analyses using binomial tests in 575 P...
January 1, 2014: Journal of Infectious Diseases
Julia Aigner, Frederik Marmé, Katharina Smetanay, Florian Schuetz, Dirk Jaeger, Andreas Schneeweiss
AIM: To compare treatment results with use of nab-paclitaxel in routine clinical practice with data obtained from clinical trials. PATIENTS AND METHODS: A retrospective chart review of all 36 patients with metastatic breast cancer treated with nab-paclitaxel was performed. Nab-paclitaxel was given weekly and usually started at 150 mg/m(2). RESULTS: Thirteen (36.1%) patients received nab-paclitaxel as first-line, seven (19.4%) as second-line and 16 as third- or further line treatment...
August 2013: Anticancer Research
Irène Baccelli, Andreas Schneeweiss, Sabine Riethdorf, Albrecht Stenzinger, Anja Schillert, Vanessa Vogel, Corinna Klein, Massimo Saini, Tobias Bäuerle, Markus Wallwiener, Tim Holland-Letz, Thomas Höfner, Martin Sprick, Martina Scharpff, Frederik Marmé, Hans Peter Sinn, Klaus Pantel, Wilko Weichert, Andreas Trumpp
It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of circulating tumor cells (CTCs) found in the blood of patients. However, although the presence of CTCs is an indicator of poor prognosis in several carcinoma entities, the existence and phenotype of metastasis-initiating cells (MICs) among CTCs has not been experimentally demonstrated. Here we developed a xenograft assay and used it to show that primary human luminal breast cancer CTCs contain MICs that give rise to bone, lung and liver metastases in mice...
June 2013: Nature Biotechnology
Moazzem Hossain, Kamruddin Ahmed, Aung Swi Prue Marma, Sohrab Hossain, Mohammad Azmat Ali, Abul Khair Mohammad Shamsuzzaman, Akira Nishizono
Globally, Bangladesh ranks third in the number of human deaths from rabies. Although dogs are the principal known transmitters of rabies and knowledge of dog populations is essential for effective national control and proper planning, dog control programs are scarce in Bangladesh. Our objective was to count dogs in a rural area to understand the dog population of the country. For this purpose we selected six unions of Raipura upazila in Narsingdi district. Dog counting was done by direct observation following accepted guidelines...
August 1, 2013: Preventive Veterinary Medicine
Frederik Marmé, Julia Aigner, Justo Lorenzo Bermejo, Peter Sinn, Christof Sohn, Dirk Jäger, Andreas Schneeweiss
We previously reported primary endpoints of two consecutive phase I/II trials, evaluating different schedules of neoadjuvant epirubicin (E), gemcitabine (G) and docetaxel (Doc) for primary breast cancer (PBC). Here, we report mature survival data and prognostic factors. One hundred fifty-one patients were recruited into two consecutive phase I/II trials of neoadjuvant chemotherapy for T2-4 N0-2 M0 PBC. Patients received six cycles of G/E/Doc every 3 weeks with G repeated on d8 (GEDoc, n = 84) or five cycles of G/E followed by four cycles of Doc all given every two weeks (GEsDoc, n = 67)...
August 15, 2013: International Journal of Cancer. Journal International du Cancer
Julia Aigner, Katharina Smetanay, Holger Hof, Hans-Peter Sinn, Christof Sohn, Andreas Schneeweiss, Frederik Marmé
OBJECTIVE: A recent, randomized trial (ACOSOG Z0011) has demonstrated that omission of completion axillary lymph node dissection (ALND) in patients with one or two sentinel lymph node (SLN) metastases treated with breast conserving therapy (BCT) does not have a negative impact on survival. This study evaluates the impact of omitting ALND on adjuvant treatment recommendations. METHODS: Performing a search of our clinical database, we identified patients meeting the main inclusion and exclusion criteria of ACOSOG Z0011 treated at the University of Heidelberg Breast Center...
May 2013: Annals of Surgical Oncology
Katharina Buck, Sarah Hug, Petra Seibold, Irmgard Ferschke, Peter Altevogt, Christof Sohn, Andreas Schneeweiss, Barbara Burwinkel, Dirk Jäger, Dieter Flesch-Janys, Jenny Chang-Claude, Frederik Marmé
Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence of CD24 polymorphisms on breast cancer prognosis and risk. A total of 2,514 patients and 4,858 controls recruited as part of the MARIE study, a population-based case-control study, were genotyped for two CD24 polymorphisms (rs52812045, rs3838646) using TaqMan custom genotyping assays...
February 2013: Breast Cancer Research and Treatment
Markus Wallwiener, Andreas Daniel Hartkopf, Irène Baccelli, Sabine Riethdorf, Sarah Schott, Klaus Pantel, Frederik Marmé, Christof Sohn, Andreas Trumpp, Brigitte Rack, Bahriye Aktas, Erich-Franz Solomayer, Volkmar Müller, Wolfgang Janni, Andreas Schneeweiss, Tanja Natascha Fehm
The detection of circulating tumor cells (CTCs) in the peripheral blood of metastatic breast cancer (MBC) patients is an independent marker of prognosis. This large prospective multicenter study aimed to assess the impact of CTCs on overall survival (OS) and progression free survival (PFS) in patients with predefined molecular subgroups of MBC. To this end, 468 MBC patients were divided into three subgroups based on immunohistochemical staining of the primary tumor: (1) hormone receptor-positive/HER2-negative (HorR+/HER2-), (2) HER2-positive (HER2+), and (3) HorR-negative/HER2-negative (HorR-/HER2-) patients...
January 2013: Breast Cancer Research and Treatment
S K Muley, N N Ingale, S D Bhingare
This study was undertaken to study Kurpara Marma in relation to its Vaikalyakara effects when injured. The location of Kurpara Marma was found with the help of the description of Marma in Ayurvedic texts, dissection of the elbow joint, and with help of X-ray documentation. Total 80 patients having trauma to elbow joints due to various causes such as fall, road traffic accident, direct trauma on elbow joint, history of trauma a year back, and injury due to burn were included in this study. These patients were observed for 3 months for any changes in symptoms...
October 2011: Ayu
Kristen N Stevens, Zachary Fredericksen, Celine M Vachon, Xianshu Wang, Sara Margolin, Annika Lindblom, Heli Nevanlinna, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Jenny Chang-Claude, Alina Vrieling, Dieter Flesch-Janys, Hans-Peter Sinn, Shan Wang-Gohrke, Stefan Nickels, Hiltrud Brauch, Yon-Dschun Ko, Hans-Peter Fischer, Rita K Schmutzler, Alfons Meindl, Claus R Bartram, Sarah Schott, Christoph Engel, Andrew K Godwin, Joellen Weaver, Harsh B Pathak, Priyanka Sharma, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Penelope Miron, Drakoulis Yannoukakos, Alexandra Stavropoulou, George Fountzilas, Helen J Gogas, Ruth Swann, Miriam Dwek, Annie Perkins, Roger L Milne, Javier Benítez, María Pilar Zamora, José Ignacio Arias Pérez, Stig E Bojesen, Sune F Nielsen, Børge G Nordestgaard, Henrik Flyger, Pascal Guénel, Thérèse Truong, Florence Menegaux, Emilie Cordina-Duverger, Barbara Burwinkel, Frederick Marmé, Andreas Schneeweiss, Christof Sohn, Elinor Sawyer, Ian Tomlinson, Michael J Kerin, Julian Peto, Nichola Johnson, Olivia Fletcher, Isabel Dos Santos Silva, Peter A Fasching, Matthias W Beckmann, Arndt Hartmann, Arif B Ekici, Artitaya Lophatananon, Kenneth Muir, Puttisak Puttawibul, Surapon Wiangnon, Marjanka K Schmidt, Annegien Broeks, Linde M Braaf, Efraim H Rosenberg, John L Hopper, Carmel Apicella, Daniel J Park, Melissa C Southey, Anthony J Swerdlow, Alan Ashworth, Nicholas Orr, Minouk J Schoemaker, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Chen-Yang Shen, Jyh-Cherng Yu, Huan-Ming Hsu, Chia-Ni Hsiung, Ute Hamann, Thomas Dünnebier, Thomas Rüdiger, Hans Ulrich Ulmer, Paul P Pharoah, Alison M Dunning, Manjeet K Humphreys, Qin Wang, Angela Cox, Simon S Cross, Malcom W Reed, Per Hall, Kamila Czene, Christine B Ambrosone, Foluso Ademuyiwa, Helena Hwang, Diana M Eccles, Montserrat Garcia-Closas, Jonine D Figueroa, Mark E Sherman, Jolanta Lissowska, Peter Devilee, Caroline Seynaeve, Rob A E M Tollenaar, Maartje J Hooning, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Esther M John, Alexander Miron, Grethe Grenaker Alnæs, Vessela Kristensen, Anne-Lise Børresen-Dale, Graham G Giles, Laura Baglietto, Catriona A McLean, Gianluca Severi, Matthew L Kosel, V S Pankratz, Susan Slager, Janet E Olson, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Diether Lambrechts, Sigrid Hatse, Anne-Sophie Dieudonne, Marie-Rose Christiaens, Georgia Chenevix-Trench, Jonathan Beesley, Xiaoqing Chen, Arto Mannermaa, Veli-Matti Kosma, Jaana M Hartikainen, Ylermi Soini, Douglas F Easton, Fergus J Couch
The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with the risk of ovarian cancer. Here, we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 OR, 1...
April 1, 2012: Cancer Research
J Heil, A Gondos, G Rauch, F Marmé, J Rom, M Golatta, H Junkermann, P Sinn, S Aulmann, J Debus, H Hof, F Schütz, H Brenner, C Sohn, A Schneeweiss
INTRODUCTION: Evaluation of oncological outcome and prognostic factors of patients with primary breast cancer treated at a certified academic breast unit. PATIENTS AND METHODS: We prospectively collected data of 3338 patients, diagnosed with primary breast cancer between 01.01.2003 and 31.12.2010 and treated at the Breast Unit Heidelberg, Germany, in order to analyze outcome in clinical practice. We evaluated local control rate (LCR), disease-free survival (DFS), distant disease-free survival (DDFS), observed overall survival (OS) and age-adjusted relative overall survival (ROS)...
June 2012: Breast: Official Journal of the European Society of Mastology
Frederik Marmé, Andreas Schneeweiss
Systemic treatment of non-metastatic breast cancer is based on endocrine therapy, cytotoxic chemotherapy, and molecular targeted therapy - with the major problems of immense overtreatment of patients who would not relapse without systemic therapy and the failure of treatment in others whose disease still recurs. These deficits can only be overcome by the identification of new and better prognostic and predictive markers. Currently, adjuvant treatment stratification is based on a limited number of established factors, namely locoregional tumour stage, age, grade, expression of hormone receptors, HER2, and Ki-67...
2012: Onkologie
Dieter Marmé, Michael Hallek
No abstract text is available yet for this article.
2012: Onkologie
Frederik Marmé, Thomas Hielscher, Sarah Hug, Sandra Bondong, Robert Zeillinger, Dan Cacsire Castillo-Tong, Jalid Sehouli, Ioana Braicu, Ignace Vergote, Cadron Isabella, Sven Mahner, Irmgard Ferschke, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Peter Altevogt
FGFR4 has been shown to play an important role in the etiology and progression of solid tumors. A single nucleotide polymorphism (SNP) within the FGFR4 gene has previously been linked to prognosis and response to chemotherapy in breast cancer and other malignancies. This study evaluates the relevance of this SNP in advanced ovarian cancer. FGFR4-genotype was analyzed in 236 patients recruited as part of the OVCAD project. Genotyping was performed on germ-line DNA using a TaqMan based genotyping assay. Results were correlated with clinicopathological variables and survival...
August 15, 2012: International Journal of Cancer. Journal International du Cancer
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