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Paraplegia

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https://www.readbyqxmd.com/read/29457116/a-spinal-cord-infarction-that-occurred-after-laparoscopic-gastrectomy-performed-under-general-anesthesia-and-epidural-analgesia
#1
Kei Houri, Shinichi Hamasaki, Takatoshi Tsujimoto, Tomohisa Uchida, Tatsushige Iwamoto, Toru Shirai, Shinichi Nakao
Background: Spinal cord infarction (SCI) after epidural anesthesia is quite rare. Although most cases of perioperative SCI are associated with aortic, cardiac, or spinal surgery, and/or abnormal preoperative conditions, such as spinal stenosis or hypercoagulopathy, intraoperative events, such as severe hypotension or epidural puncture and catheterization, can be contributory factors. Case presentation: A 52-year-old male was underwent laparoscopic gastrectomy. Before induction of general anesthesia, an epidural catheter was placed without any problems...
2018: JA Clin Rep
https://www.readbyqxmd.com/read/29455493/-classification-of-upper-cervical-fractures-a-review
#2
REVIEW
Peng-Rong Ouyang, Xi-Jing He, Xuan Cai
Upper cervical fracture-dislocations are series of pathological injuries occurred in occipital, atlas and axis caused by traumatic impact, which often results in severe clinical consequences, such as paraplegia, quadriplegia, and even death. In light of the potential severe clinical outcomes, it is important to define the type of upper cervical fracture-dislocations depending on which the clinician can deal with the disease properly. Owing to its specific anatomical structures, the upper cervical fractures occurr to the unique osseous structures or ligamentous connections always present in predictable patterns...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29454663/novel-pla2g6-mutations-and-clinical-heterogeneity-in-chinese-cases-with-phospholipase-a2-associated-neurodegeneration
#3
Yi-Jun Chen, Yu-Chao Chen, Hai-Lin Dong, Li-Xi Li, Wang Ni, Hong-Fu Li, Zhi-Ying Wu
INTRODUCTION: Phospholipase A2-associated neurodegeneration (PLAN) is an autosomal recessive movement disorder with abnormal iron deposition in basal ganglia, substantial nigra and adjacent areas, and cerebellar atrophy. It is caused by PLA2G6 mutations and comprises three phenotypes. We aimed to investigate genetic mutations in patients with predominantly extrapyramidal symptoms. METHODS: Eighteen Chinese patients with early onset of extrapyramidal symptoms were identified and underwent targeted next-generation sequencing, followed by Sanger sequencing...
February 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29453783/affordances-after-spinal-cord-injury
#4
Anna Sedda, Ettore Ambrosini, Giada Dirupo, Diana Tonin, Laura Valsecchi, Tiziana Redaelli, Michele Spinelli, Marcello Costantini, Gabriella Bottini
Spinal cord injury can cause cognitive impairments even when no cerebral lesion is appreciable. As patients are forced to explore the environment in a non-canonical position (i.e., seated on a wheelchair), a modified relation with space can explain motor-related cognitive differences compared to non-injured individuals. Peripersonal space is encoded in motor terms, that is, in relation to the representation of action abilities and is strictly related to the affordance of reachability. In turn, affordances, the action possibilities suggested by relevant properties of the environment, are related to the perceiver's peripersonal space and motor abilities...
February 16, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29453415/erlin1-mutations-cause-teenage-onset-slowly-progressive-als-in-a-large-turkish-pedigree
#5
Ceren Tunca, Fulya Akçimen, Cemre Coşkun, Aslı Gündoğdu-Eken, Cemile Kocoglu, Betül Çevik, Can Ebru Bekircan-Kurt, Ersin Tan, A Nazlı Başak
Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disease with mostly dominant inheritance and a life expectancy of 2-5 years; however, a quite common occurrence of atypical forms of the disease, due to recessive inheritance, has become evident with the use of NGS technologies. In this paper, we describe a family with close consanguinity for at least four generations, suffering from a slowly progressive form of ALS. Spastic walking is observed since teenage years, while bulbar symptoms start much later, at the fifth or sixth decade of life...
February 16, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29453362/long-term-bladder-and-bowel-management-after-spinal-cord-injury-a-20-year-longitudinal-study
#6
Gordana Savic, Hans L Frankel, Mohamed Ali Jamous, Bakulesh M Soni, Susan Charlifue
STUDY DESIGN: Prospective observational. AIM: The aim of this study was to analyse changes in bladder and bowel management methods in persons with long-standing spinal cord injury (SCI). SETTING: Two spinal centres in UK. METHOD: Data were collected through interviews and examinations between 1990 and 2010 in a sample of persons injured more than 20 years prior to 1990. RESULTS: For the 85 participants who completed the 2010 follow-up, the mean age was 67...
February 16, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29451229/m-aaa-proteases-mitochondrial-calcium-homeostasis-and-neurodegeneration
#7
REVIEW
Maria Patron, Hans-Georg Sprenger, Thomas Langer
The function of mitochondria depends on ubiquitously expressed and evolutionary conserved m-AAA proteases in the inner membrane. These ATP-dependent peptidases form hexameric complexes built up of homologous subunits. AFG3L2 subunits assemble either into homo-oligomeric isoenzymes or with SPG7 (paraplegin) subunits into hetero-oligomeric proteolytic complexes. Mutations in AFG3L2 are associated with dominant spinocerebellar ataxia (SCA28) characterized by the loss of Purkinje cells, whereas mutations in SPG7 cause a recessive form of hereditary spastic paraplegia (HSP7) with motor neurons of the cortico-spinal tract being predominantly affected...
February 16, 2018: Cell Research
https://www.readbyqxmd.com/read/29445509/a-case-of-paraplegia-that-developed-6-years-after-thoracic-endovascular-aortic-repair-for-blunt-traumatic-aortic-injury
#8
Hiroyuki Takahashi, Tomohisa Shoko, Fumino Taketazu, Keiichi Kuriyama, Kazuhide Yoshikawa, Yoshizumi Deguchi
Case: Thoracic endovascular aortic repair (TEVAR) is becoming the standard therapy for blunt thoracic aortic injury (BTAI). However, the long-term outcomes of TEVAR for BTAI remain unclear. A 36-year-old man was admitted to our emergency department with dyspnea. He had been involved in a serious traffic accident 6 years earlier, requiring TEVAR for BTAI. Outcome: Acute heart failure and pneumonia were diagnosed on this admission. His respiratory condition improved, but paraplegia developed 10 h after hospitalization...
January 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29438993/identification-of-progesterone-receptor-membrane-component-1-as-an-interaction-partner-and-possible-regulator-of-fatty-acid-2-hydroxylase
#9
Robert Hardt, Dominic Winter, Volkmar Gieselmann, Matthias Eckhardt
The fatty acid 2-hydroxylase (FA2H) is essential for synthesis of 2-hydroxylated fatty acids in myelinating and other cells and deficiency of this enzyme causes a complicated form of hereditary spastic paraplegia also known as fatty acid hydroxylase-associated neurodegeneration. Despite its important role in sphingolipid metabolism, regulation of FA2H and its interaction with other proteins involved in the same or other metabolic pathways is poorly understood. To identify potential interaction partners of the enzyme, quantitative mass-spectrometry using stable isotope labeling of cells was combined with formaldehyde cross-linking and proximity biotinylation, respectively...
February 9, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29429247/-clinical-research-on-acute-paraplegia-resulting-from-intrathecal-chemotherapy
#10
M Cheng, L Xue, Y J Li, Q Jiang, J Zhang, X G Gao
Objective: To investigate the potential pathogenesis of acute paraplegia resulting from intrathecal chemotherapy and to analyze the factors influencing prognosis. Methods: Six cases presented with acute paraplegia after intrathecal chemotherapy for leukemia from January 1(st,) 2015 to June 1(st,) 2017 in our hospital. The patients' clinical manifestation, data of imaging and cerebrospinal fluid were analyzed. Result: Six patients with leukemia were with an average age of 27.3 (7 to 55) years old. Four cases were intrathecally injected with cytarabine, and two cases were intrathecally injected with cytarabine and methotrexate...
January 30, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29428293/impact-of-spine-alignment-on-the-rotator-cuff-in-long-term-wheelchair-users
#11
Yasser Kentar, Manuela Brunner, Thomas Bruckner, Andreas Hug, Patric Raiss, Felix Zeifang, Markus Loew, Haidara Almansour, Michael Akbar
BACKGROUND: We investigated the impact of poor seated posture on the prevalence of rotator cuff tears (RCTs) among wheelchair-dependent individuals with long-standing paraplegia. METHODS: The study included 319 patients. Lateral radiographs of the spine were collected from a database and analyzed to assess the global spinopelvic alignment (SPA). Magnetic resonance images of both shoulders were obtained to detect the presence of cuff tears. Patients were divided into 2 groups: Group RCT-I included all patients with cuff tears (right, left, or bilateral), whereas group RCT-II consisted exclusively of patients with bilateral cuff tears...
February 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29427797/severe-lower-limb-cellulitis-defining-the-epidemiology-and-risk-factors-for-primary-episodes-in-a-population-based-case-control-study
#12
Jeffrey Cannon, Gawri Rajakaruna, John Dyer, Jonathan Carapetis, Laurens Manning
OBJECTIVE: To describe the epidemiology and risk factors for primary episodes of severe lower leg cellulitis (LLC). METHODS: A longitudinal cohort study using state-wide data linkage of adults presenting to Western Australian (WA) hospitals with a first ever LLC from January 2002 to December 2013. To determine risk factors, medical records from the index patient, together with comparable data from controls matched by age, sex, postcode and month of admission were extracted...
February 7, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29423886/paraplegic-patients-how-to-measure-balance-and-what-is-normal-or-functional
#13
REVIEW
Kaku Barkoh, Joshua W Lucas, Larry Lee, Patrick C Hsieh, Jeffrey C Wang, Kevin Rolfe
PURPOSE: To review the current understanding and data of sagittal balance and alignment considerations in paraplegic patients. METHODS: A PubMed literature search was conducted to identify all relevant articles relating to sagittal alignment and sagittal balance considerations in paraplegic and spinal cord injury patients. RESULTS: While there are numerous studies and publications on sagittal balance in the ambulatory patient with spinal deformity or complex spine disorders, there is paucity of the literature on "normal" sagittal balance in the paraplegic patients...
February 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29423566/clinical-and-neuroimaging-features-of-autosomal-recessive-spastic-paraplegia-35-spg35-case-reports-new-mutations-and-brief-literature-review
#14
Francesco Mari, Beatrice Berti, Alessandro Romano, Jacopo Baldacci, Riccardo Rizzi, M Grazia Alessandrì, Alessandra Tessa, Elena Procopio, Anna Rubegni, Charles Marques Lourenḉo, Alessandro Simonati, Renzo Guerrini, Filippo Maria Santorelli
Spastic paraplegia 35 (SPG35) is a recessive condition characterized by childhood onset, progressive course, complicated by dystonia, dysarthria, cognitive impairment, and epilepsy. Mutations in the FA2H gene have been described in several families, leading to the proposal of a single entity, named fatty acid hydrolase-associated neurodegeneration (FAHN). Several reports have described a polymorphic radiological picture with white matter lesions of various degrees and a distinct form of neurodegeneration with brain iron accumulation...
February 8, 2018: Neurogenetics
https://www.readbyqxmd.com/read/29423314/adverse-cognitive-effect-of-gabapentin-in-individuals-with-spinal-cord-injury-preliminary-findings
#15
Kazuko Shem, Steven Barncord, Kara Flavin, Manoj Mohan
Study design: Prospective observational cohort study. Objectives: To assess the effects of gabapentin on neuropsychological variables including memory, attention, and executive function in individuals with spinal cord injury. Setting: Santa Clara Valley Medical Center inpatient spinal cord injury unit. Methods: Ten patients (three females, seven males) with traumatic spinal cord injury underwent testing, with a mean age of 35...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29423312/epidemiological-profile-of-spinal-cord-injuries-at-a-tertiary-rehabilitation-center-in-kuwait
#16
L Prasad, S Al Kandari, U Ramachandran, D Shehab, S Alghunaim
Study design: Retrospective, descriptive study. Objective: To describe the epidemiological profile of patients with spinal cord injury (SCI) in Kuwait. Setting: Physical Medicine and Rehabilitation Hospital, Kuwait. Methods: Review of medical records of 241 adult patients with SCI admitted during the period 2010-2015. The data collected included gender, age, etiology, neurological and vertebral level of injury and American Spinal Injury Association impairment scale (AIS)...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29423310/audio-visual-distraction-as-an-adjunct-to-standby-anaesthesia-in-persons-with-paraplegia-a-case-series-of-five-operations
#17
Khurram Ayub, Ruth A Corrigan, Jyoti Misra, Svetlana Galitzine
Introduction: Persons with paraplegia present complex challenges to anaesthetists. Complications experienced by these patients can require major orthoplastic surgery such as excision of infected bone and soft tissue due to pressure sores and soft tissue reconstruction. Anaesthetic strategies deemed both safe and acceptable to this population are essential. Case presentation: We report a case series of five procedures in four patients with complete chronic spinal cord injury (CSCI) who underwent operations in lateral position under standby anaesthesia and audio-visual distraction (AVD) with minimal sedation...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29421991/association-of-early-onset-spasticity-and-risk-for-cognitive-impairment-with-mutations-at-amino-acid-499-in-spast
#18
Meredith K Gillespie, Peter Humphreys, Hugh J McMillan, Kym M Boycott
Hereditary spastic paraplegia is a phenotypically and genetically heterogeneous group of neurodegenerative disorders characterized by lower extremity weakness and spasticity. Spastic paraplegia 4 (SPG4), caused by heterozygous mutations in the gene SPAST, typically causes a late-onset, uncomplicated form of hereditary spastic paraplegia in affected individuals. Additional clinical features in SPG4 have been reported on occasion, but no genotype-phenotype correlation has been established. Through targeted clinical testing, we identified 2 unrelated female patients with the same de novo p...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29417244/secondary-raynaud-s-phenomenon-and-skin-necrosis-of-toes-in-the-paraplegic-patient-with-hypertension
#19
Yong Jig Lee, Kisoo Park
We present two cases of paraplegic patients who developed secondary Raynaud's phenomenon. A 43-year-old man with paraplegia presented with dark purple discoloration and skin defects on his left second and third toes and complained of a cold sensation in both feet for a period of 1 year. He had been taking diuretics for 4 years. The capillary refilling time for both affected toes was delayed. His antihypertensive drug was changed to a calcium channel blocker under suspicion of Raynaud's phenomenon aggravated by hydrochlorothiazide, and the capillary refilling time normalized within 3 days...
February 7, 2018: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29416908/acute-tetraplegia-following-laryngotracheal-reconstruction-surgery
#20
Belgin Erhan, Rahsan Kemerdere, Osman Kizilkilic, Berrin Gunduz, Murat Hanci
Background: Paraplegia following thoracic spinal surgery or abdominal operations is usually attributed to spinal cord ischemia due to interruption of the segmental spinal vascular supply. Alternatively, the etiology of spinal cord ischemia following cervical surgery is less clear. Case Description: A 14-year-old male became acutely tetraplegic with a C4 sensory level and sphincteric dysfunction 12 h following surgery for tracheal stenosis due to prior intubation...
2018: Surgical Neurology International
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