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https://www.readbyqxmd.com/read/28649492/relationship-between-brainstem-neurodegeneration-and-clinical-impairment-in-traumatic-spinal-cord-injury
#1
Patrick Grabher, Claudia Blaiotta, John Ashburner, Patrick Freund
BACKGROUND: Brainstem networks are pivotal in sensory and motor function and in recovery following experimental spinal cord injury (SCI). OBJECTIVE: To quantify neurodegeneration and its relation to clinical impairment in major brainstem pathways and nuclei in traumatic SCI. METHODS: Quantitative MRI data of 30 chronic traumatic SCI patients (15 with tetraplegia and 15 with paraplegia) and 23 controls were acquired. Patients underwent a full neurological examination...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28645597/spinal-arteriovenous-malformation-associated-with-parkes-weber-syndrome-report-of-two-cases-and-literature-review
#2
Zi-Fu Li, Qiang Li, Yi Xu, Bo Hong, Qing-Hai Huang, Jian-Min Liu
OBJECTIVE: To present two cases of Parkes Weber syndrome (PWS) with spinal arteriovenous malformation(AVM), and discuss the radiological features and clinical treatment with literature review. METHODS: Clinical data on two PWS patients with spinal AVM was acquired in a prospective follow-up investigation. Clinical manifestations, radiographic features, procedural results and follow-up outcome were collected and reviewed together with literature review. RESULTS: The first patient presented with limb weakness and urinary dysfunction and the second with repetitive subarachnoid hemorrhage followed by paraplegia...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28642680/weight-bearing-over-ground-stepping-in-an-exoskeleton-with-non-invasive-spinal-cord-neuromodulation-after-motor-complete-paraplegia
#3
Parag Gad, Yury Gerasimenko, Sharon Zdunowski, Amanda Turner, Dimitry Sayenko, Daniel C Lu, V Reggie Edgerton
We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely absent of vision (>15 year) using two novel strategies-transcutaneous electrical spinal cord stimulation at selected sites over the spine as well as pharmacological neuromodulation by buspirone. We also asked whether these neuromodulatory strategies could facilitate stepping assisted by an exoskeleton (EKSO, EKSO Bionics, CA) that is designed so that the subject can voluntarily complement the work being performed by the exoskeleton...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28637146/instilling-positive-beliefs-about-disabilities-pilot-testing-a-novel-experiential-learning-activity-for-rehabilitation-students
#4
Arielle M Silverman, Jennifer S Pitonyak, Ian K Nelson, Patricia N Matsuda, Deborah Kartin, Ivan R Molton
PURPOSE: To develop and test a novel impairment simulation activity to teach beginning rehabilitation students how people adapt to physical impairments. METHODS: Masters of Occupational Therapy students (n = 14) and Doctor of Physical Therapy students (n = 18) completed the study during the first month of their program. Students were randomized to the experimental or control learning activity. Experimental students learned to perform simple tasks while simulating paraplegia and hemiplegia...
February 25, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28629784/-from-paediatric-urological-care-to-adult-urology-assessment-of-a-transition-consultation-for-adolescents
#5
L Even, S Mouttalib, J Moscovici, M Soulie, P Rischmann, X Game, P Galinier, O Bouali
To provide an adequate lifelong urological care in the complex period of adolescence, a transition consultation conducted by a paediatric surgeon and an urologist was developed in our institution. As a real rite of passage, it allows the follow-up and the adapted care of urological conditions, sometimes complex, and permits the transition between childhood and the world of grown-ups. We reported our experience at the Children Hospital of our institution (paediatric surgery and urology departments). During a 6 months period (January-July 2015), forty-five young adults with a mean age of 17...
June 16, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28629390/results-of-the-first-interim-analysis-of-the-rapper-ii-trial-in-patients-with-spinal-cord-injury-ambulation-and-functional-exercise-programs-in-the-rex-powered-walking-aid
#6
Nick Birch, Jon Graham, Tom Priestley, Chris Heywood, Mohamed Sakel, Angela Gall, Andrew Nunn, Nada Signal
BACKGROUND: The RAPPER II study investigates the feasibility, safety and acceptability of using the REX self-stabilising robotic exoskeleton in people with spinal cord injury (SCI) who are obligatory wheelchair users. Feasibility is assessed by the completion of transfer into the REX device, competency in achieving autonomous control and completion of upper body exercise in an upright position in the REX device. Safety is measured by the occurrence of serious adverse events. Device acceptability is assessed with a user questionnaire...
June 19, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28628542/a-rare-intramedullary-spinal-cord-metastasis-from-a-retroperitoneal-leiomyosarcoma-presenting-as-a-non-traumatic-spinal-cord-injury
#7
Andrew Lamberth Parker, Terrence Pugh, Mark A Hirsch
Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28626794/febrile-ataxia-and-myokymia-broaden-the-spg26-hereditary-spastic-paraplegia-phenotype
#8
Rubina Dad, Susan Walker, Stephen W Scherer, Muhammad Jawad Hassan, Mohammad Domaia Alghamdi, Berge A Minassian, Reem A Alkhater
No abstract text is available yet for this article.
June 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28625083/spinal-cord-ischemia-after-endoscopic-ultrasound-guided-celiac-plexus-neurolysis-case-report-and-review-of-the-literature
#9
Ibrahim Hakkı Köker, Ayşe Aralaşmak, Nurcan Ünver, Talip Asil, Hakan Şentürk
INTRODUCTION: Endosonography guided celiac plexus neurolysis is efficacious in the management of severe pain due to advanced pancreatic cancer. Although endoscopic ultrasound (EUS) guided celiac neurolysis (CN) is mostly a safer procedure than the percutaneous posterior approach, severe complications such as paraplegia have been reported. CASE REPORT: We describe a patient with advanced adenocarcinoma of the pancreas and severe pain who developed irreversible paraplegia after EUS guided CN...
June 18, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28623144/cardiovascular-stress-during-inpatient-spinal-cord-injury-rehabilitation
#10
Dominik Zbogar, Janice J Eng, William C Miller, Andrei V Krassioukov, Mary C Verrier
OBJECTIVES: 1) To measure the amount of a) cardiovascular stress, b) self-reported physical activity and c) accelerometry-measured physical activity by individuals with SCI during physical therapy (PT) and occupational therapy (OT) and, 2) to investigate the relationship between these measures. DESIGN: Observational study. SETTING: Two inpatient SCI rehabilitation centres. PARTICIPANTS: SCI patients (n=87) were recruited from consecutive admissions to rehabilitation...
June 13, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28616291/intensive-blood-pressure-control-in-patients-with-acute-type-b-aortic-dissection-raid-study-protocol-for-randomized-controlled-trial
#11
REVIEW
Jian-Cang Zhou, Nan Zhang, Zhong-Heng Zhang, Ting-Ting Wang, Yue-Feng Zhu, Hui Kang, Wei-Min Zhang, Dong-Lin Li, Wei-Dong Li, Zhen-Jie Liu, Xi-Min Qian, Ming-You Zhang, Jue Wang, Mi Zhou, Zhi-Tao Yang, Yun-Xian Yu, Hang-Yang Li, Jian Zhang, Yong-Gang Wang, Jian-Ping Gao, Lin Ling, Kong-Han Pan
BACKGROUND: Blood pressure control is an essential therapy for patients with acute type B aortic dissection (ABAD) and should be maintained throughout the entire treatment. Thus, vast majority current guidelines recommend control the blood pressure to lower than 140/90 mmHg. Theoretically, a much lower target may further decrease the risk of propagation of dissection. However, some argued that too lower blood pressure would compromise the organ perfusion. Thus, there is no unanimous optimal target for blood pressure in patients with ABAD so far...
May 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28611986/scipad-effective-implementation-of-telemedicine-using-ipads-with-individuals-with-spinal-cord-injuries-a-case-series
#12
Kazuko Shem, Samantha J Sechrist, Eleanor Loomis, Linda Isaac
BACKGROUND: Individuals with spinal cord injury (SCI) must often travel long distances to see a rehabilitation specialist. While telemedicine (TM) for pressure ulcer management has been used in this population, real-time video telecommunication using iPad has never been described. OBJECTIVE: The objective of this study was to provide specialized care for persons with SCI through TM consultation expediently in order to address medical needs, manage secondary complications, and to improve quality of life (QoL) of individuals with SCI...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28611846/safety-of-allogeneic-canine-adipose-tissue-derived-mesenchymal-stem-cell-intraspinal-transplantation-in-dogs-with-chronic-spinal-cord-injury
#13
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28605479/collapsed-stent-graft-and-severe-malperfusion-2%C3%A2-years-after-endovascular-aortic-repair
#14
Yoshihiro Goto, Soh Hosoba, Shinji Ogawa, Yoshihisa Kinoshita
Late collapsing of a stent graft is an extremely rare event, with one existing report describing this phenomenon. A 65-year-old man with a history of endovascular aortic repair for an abdominal aortic aneurysm presented with paraplegia and bilateral lower limb ischaemia. Contrast-enhanced computed tomography showed a dissection of the descending thoracic aorta and a collapsed stent graft, resulting in bilateral lower limb ischaemia. Subsequent axillo-bifemoral bypass resolved his lower extremity functions. The patient required haemodialysis due to acute kidney failure...
June 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28604325/characteristics-and-outcomes-of-gunshot-acquired-spinal-cord-injury-in-south-africa
#15
Conran Joseph
BACKGROUND: Spinal cord injuries (SCIs) caused by assault present a unique challenge facing the healthcare system, in that very little is known about how these injuries manifest compared with other causes of injury. Understanding the nuances of gunshot SCIs could contribute towards better care provision. OBJECTIVE: To determine the characteristics of gunshot SCI and compare both injury characteristics and outcomes between gunshot SCI and all other traumatic causes taken together...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28600743/-ataxias-and-hereditary-spastic-paraplegias
#16
REVIEW
R Schüle, L Schöls
Hereditary ataxias and spastic paraplegias are genetic disorders with age-dependent nearly complete penetrance. The mostly monogenetic etiology allows one to establish the diagnosis, study pathogenesis and to develop new causative therapeutic approaches for these diseases. Both the causative genes as well as the clinical presentation overlap considerably between hereditary ataxias and spastic paraplegias. This strongly argues towards a united classification for these two groups of diseases. Next generation sequencing technologies have greatly expanded the number of genes known to be causative for hereditary ataxias and spastic paraplegias and allow simultaneous time- and cost-effective diagnostic testing of > 200 genes...
June 9, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28599840/complications-and-operative-spine-fusion-construct-length-in-parkinson-s-disease-a-nationwide-population-based-analysis
#17
Shearwood McClelland, Joseph F Baker, Justin S Smith, Breton G Line, Robert A Hart, Christopher P Ames, R Shay Bess
There remains a dearth of information regarding the surgical complications following multilevel spine surgery in Parkinson's disease (PD) patients. This retrospective cohort study was performed to address this issue on a nationwide level using the Nationwide Inpatient Sample from 2001 to 2012. More than 25 postoperative variables were analyzed to assess the impact of fusion construct length on each variable. Subsequently, the same analysis was performed on admissions without PD. 4301 PD patients with spine fusion were identified, of whom 934 (21...
June 6, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28597908/chronic-pain-depression-and-quality-of-life-in-individuals-with-spinal-cord-injury-mediating-role-of-participation
#18
Rachel Müller, Gunther Landmann, Markus Béchir, Timo Hinrichs, Ursina Arnet, Xavier Jordan, Martin W G Brinkhof
OBJECTIVE: To test the hypotheses that: (i) pain is associated with depressive symptoms and quality of life; and (ii) participation restriction, satisfaction, and frequency mediate these relationships. DESIGN: Population-based, cross-sectional study. SUBJECTS/PATIENTS: Community-dwelling individuals with spinal cord injury (n = 1,549). METHODS: Hypotheses were tested in individuals with at least moderate chronic pain on the spinal cord injury - Secondary Conditions Scale (n = 834), applying structural equation modelling to data for spinal cord injury subgroups related to lesion severity (paraplegia, tetraplegia, complete, incomplete) and time since injury (≤ 10 vs ≥ 10 years)...
June 8, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28593744/thermosensitive-heparin-poloxamer-hydrogels-enhance-the-effects-of-gdnf-on-neuronal-circuit-remodelling-and-neuroprotection-after-spinal-cord-injury
#19
Ying-Zheng Zhao, Xi Jiang, Qian Lin, He-Lin Xu, Ya-Dong Huang, Cui-Tao Lu, Jun Cai
Traumatic spinal cord injury (SCI) results in paraplegia or quadriplegia, and currently, therapeutic interventions for axonal regeneration after SCI are not clinically available. Animal studies have revealed that glial cell-derived neurotrophic factor (GDNF) plays multiple beneficial roles in neuroprotection, glial scarring remodelling, axon regeneration and remyelination in SCI. However, the poor physicochemical stability of GDNF, as well as its limited ability to cross the blood-spinal cord barrier, hampers the development of GDNF as an effective therapeutic intervention in clinical practice...
June 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28592010/-clinical-diagnosis-and-treatment-of-three-cases-with-hyperornithinemia-hyperammonemia-homocitrullinuria-syndrome
#20
H Z Guan, Y Ding, D X Li, H Dong, J Q Song, Y Jin, Z J Zhu, L Y Sun, Y L Yang
Objective: To study the clinical characteristics, methods of diagnosis and treatment of hyperornithinemia-hyperammonemia- homocitrullinuria (HHH) syndrome. Method: From July 2011 to August 2016, 3 Chinese patients with HHH syndrome were enrolled in this study. The clinical course, biochemical features, brain MRI findings, and gene mutations were analyzed. Result: The three patients' age at onset of symptoms was 3 months to 7 years, and the age of diagonosis was 3 years and 10 months to 9 years and 10 months...
June 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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