Hamid Hasanpour, Reza Falak, Kobra Mokhtarian, Fatemeh Sadeghi, Elham Masoumi, Parisa Asadollahi, Alireza Badirzadeh, Sanaz Jafarpour Azami, Mohammad Davoodzadeh Gholami, Salar Pashangzadeh, Mohammad Javad Gharagozlou, Razi Naserifar, Gholamreza Mowlavi
The immunomodulatory potential of the excretory-secretory (E/S) proteins of the helminths has been shown in previous investigations. This study evaluated the effects of the recombinants and excretory-secretory proteins of the Fasciola hepatica on induced colitis in Balb/c mice. The F. hepatica Recombinant proteins, Cathepsin L1 and Peroxiredoxin, and E/S proteins were intraperitoneally injected into the three mice groups as the case groups, while the control groups received PBS. Colitis was induced in mice by intraluminal administration of the 2, 4, 6-Trinitrobenzenesulfonic acid solution (TNBS)...
January 2024: Parasite Immunology