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https://www.readbyqxmd.com/read/28079156/a-mucin-like-peptide-from-fasciola-hepatica-instructs-dendritic-cells-with-parasite-specific-th1-polarizing-activity
#1
Verónica Noya, Natalie Brossard, Ernesto Rodríguez, L Sebastián Dergan-Dylon, Carlos Carmona, Gabriel A Rabinovich, Teresa Freire
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote dendritic cell (DC) maturation, endowing these cells with Th1-polarizing capacity. Exposure of DCs to Fhmuc in presence of LPS induced enhanced secretion of pro-inflammatory cytokines and expression of co-stimulatory molecules by DCs, promoting their T cell stimulatory capacity and selectively augmenting IFN-γ secretion by allogeneic T cells...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060841/genomes-of-fasciola-hepatica-from-the-americas-reveal-colonization-with-neorickettsia-endobacteria-related-to-the-agents-of-potomac-horse-and-human-sennetsu-fevers
#2
Samantha N McNulty, Jose F Tort, Gabriel Rinaldi, Kerstin Fischer, Bruce A Rosa, Pablo Smircich, Santiago Fontenla, Young-Jun Choi, Rahul Tyagi, Kymberlie Hallsworth-Pepin, Victoria H Mann, Lakshmi Kammili, Patricia S Latham, Nicolas Dell'Oca, Fernanda Dominguez, Carlos Carmona, Peter U Fischer, Paul J Brindley, Makedonka Mitreva
Food borne trematodes (FBTs) are an assemblage of platyhelminth parasites transmitted through the food chain, four of which are recognized as neglected tropical diseases (NTDs). Fascioliasis stands out among the other NTDs due to its broad and significant impact on both human and animal health, as Fasciola sp., are also considered major pathogens of domestic ruminants. Here we present a reference genome sequence of the common liver fluke, Fasciola hepatica isolated from sheep, complementing previously reported isolate from cattle...
January 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28043381/characterization-and-vaccine-potential-of-fasciola-gigantica-saposin-like-protein-1-sap-1
#3
Pornanan Kueakhai, Narin Changklungmoa, Pinkamon Waseewiwat, Thanaporn Thanasinpaiboon, Werachon Cheukamud, Pannigan Chaichanasak, Prasert Sobhon
The recombinant Fasciola gigantica Saposin-like protien-1 (rFgSAP-1) was cloned by polymerase chain reaction (PCR) from NEJ cDNA, expressed in Escherichia coli BL21 (DE3) and used for production of a polyclonal antibody in rabbits (anti-rFgSAP-1). By immunoblotting and immunohistochemistry, rabbit IgG anti-rFgSAP-1 reacted with rFgSAP-1 at a molecular weight 12kDa, but not with rFgSAP-2. The rFgSAP-1 reacted with antisera from mouse infected with F. gigantica metacercariae collected at 2, 4, and 6 weeks after infection...
January 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28026895/self-fertilization-long-distance-flash-invasion-and-biogeography-shape-the-population-structure-of-pseudosuccinea-columella-at-the-worldwide-scale
#4
M Lounnas, A C Correa, A A Vázquez, A Dia, J S Escobar, A Nicot, J Arenas, R Ayaqui, M P Dubois, T Gimenez, A Gutiérrez, C González-Ramírez, O Noya, L Prepelitchi, N Uribe, C Wisnivesky-Colli, M Yong, P David, E S Loker, P Jarne, J P Pointier, S Hurtrez-Boussès
Population genetic studies are efficient for inferring the invasion history based on a comparison of native and invasive populations, especially when conducted at species scale. An expected outcome in invasive populations is variability loss, and this is especially true in self-fertilizing species. We here focus on the self-fertilizing Pseudosuccinea columella, an invasive hermaphroditic freshwater snail that has greatly expanded its geographic distribution and that acts as intermediate host of Fasciola hepatica, the causative agent of human and veterinary fasciolosis...
December 27, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/28000591/relative-importance-of-meteorological-and-geographical-factors-in-the-distribution-of-fasciola-hepatica-infestation-in-farmed-sheep-in-qinghai-province-china
#5
Hongyu Qin, Xiang Gao, Hongbin Wang, Jianhua Xiao
Fasciola hepatica is an important trematode parasite of economic importance that infests sheep and cattle worldwide. We conducted a detailed investigation into the spatial distribution of F. hepatica infestation in farmed sheep in Qinghai (Wutumeiren) province, Mainland China. Mathematical modelling was used to assess the inter-relationships between meteorological and geographical factors and the risk of F. hepatica infestation across the province. A capture enzyme-linked immunosorbent assay (ELISA) test (MM3-SERO) was used to detect F...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27957438/molecular-characterization-of-animal-fasciola-spp-isolates-from-kermanshah-western-iran
#6
Arezoo Bozorgomid, Naser Nazari, Hamzeh Rahimi, Eshrat Beigom Kia, Homa Hajjaran, Mehdi Mohebali, Mojgan Aryaeipour, Peyman Heidarian, Mohammad Saeid Ezati, Mohamad Bagher Rokni
BACKGROUND: We evaluated the genetic diversity of samples identified morphologically as Fasciola spp. from sheep, cattle and goat from Kermanshah Province, western Iran using PCR-RFLP method. METHODS: We used PCR-RFLP analysis of ribosomal ITS1 fragment using RsaI restriction enzyme to investigate the genetic characteristics of Fasciola species obtained from different hosts (16 sheep, 28 cattle, 4 goats). The species of Fasciola were confirmed by sequencing the 700 bp region of ribosomal ITS1 gene...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27940066/fasciola-hepatica-demonstrates-high-levels-of-genetic-diversity-a-lack-of-population-structure-and-high-gene-flow-possible-implications-for-drug-resistance
#7
Nicola J Beesley, Diana J L Williams, Steve Paterson, Jane Hodgkinson
Fasciola hepatica, the liver fluke, is a trematode parasite of considerable economic importance to the livestock industry and is a re-emerging zoonosis that poses a risk to human health in F. hepatica-endemic areas worldwide. Drug resistance is a substantial threat to the current and future control of F. hepatica, yet little is known about how the biology of the parasite influences the development and spread of resistance. Given that F. hepatica can self-fertilise and therefore inbreed, there is the potential for greater population differentiation and an increased likelihood of recessive alleles, such as drug resistance genes, coming together...
December 7, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27906040/identity-of-fasciola-spp-in-sheep-in-egypt
#8
Said Amer, Ahmed ElKhatam, Shereif Zidan, Yaoyu Feng, Lihua Xiao
BACKGROUND: In Egypt, liver flukes, Fasciola spp. (Digenea: Fasciolidae), have a serious impact on the farming industry and public health. Both Fasciola hepatica and Fasciola gigantica are known to occur in cattle, providing the opportunity for genetic recombination. Little is known on the identity and genetic variability of Fasciola populations in sheep. METHODS: This study was performed to determine the prevalence of liver flukes in sheep in Menofia Province as a representative area of the delta region in Egypt, as measured by postmortem examination of slaughtered animals at three abattoirs...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27905284/parasites-determined-by-fecal-examination-in-horses-in-erzurum
#9
Hamza Avcıoğlu, Esin Güven, İbrahim Balkaya, Şevki Yavuz, Uğur Abay, Muzaffer Akyüz, Ömer Eltas
OBJECTIVE: This study aimed to determine the parasites present in horses belonging to the Erzurum Province. METHODS: Fecal samples were collected from 76 horses of different ages, genders and breeds in Erzurum. Individual fecal samples were collected and examined by flotation and sedimentation methods. RESULTS: The following species were detected: strongylid egg (57.89%), Parascaris equorum (10.52%), Dicrocoelium dendriticum (2.63%), Fasciola spp...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27894356/transmission-of-calicophoron-daubneyi-and-fasciola-hepatica-in-galicia-spain-temporal-follow-up-in-the-intermediate-and-definitive-hosts
#10
Javier Iglesias-Piñeiro, Marta González-Warleta, José Antonio Castro-Hermida, María Córdoba, Camino González-Lanza, Yolanda Manga-González, Mercedes Mezo
BACKGROUND: Paramphistomosis caused by Calicophoron daubneyi and fasciolosis caused by Fasciola hepatica are common parasitic diseases of livestock animals. Transmission of the diseases depends on the presence of intermediate hosts, i.e. freshwater gastropods such as lymnaeids. We carried out a 2-year-long study of the dynamics of the snail population acting as the intermediate host for these parasites, considering the population structure in terms of size/age and infection status. In addition, we determined the kinetics of trematode egg excretion in grazing cows...
November 29, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27890084/comparison-of-molecular-and-conventional-methods-for-the-diagnosis-of-fasciola-hepatica-infection-in-the-field
#11
COMPARATIVE STUDY
Maria Immaculata Arifin, Johan Höglund, Adam Novobilský
The liver fluke, Fasciola hepatica, is one of the major parasite threats to livestock industries world-wide. In sheep and cattle, F. hepatica infection is commonly diagnosed using a range of methods. Aside from conventional coprological and serological diagnostic methods, there are also several molecular methods available based on the detection of liver fluke DNA in faeces. In this study, the outcomes of faecal egg count (FEC), serology and coproantigen ELISA (cELISA) were compared with the performance of polymerase chain reaction (PCR) and loop-mediated isothermal amplification (LAMP) in diagnosis of F...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27890078/animal-fascioliasis-perspectives-from-high-altitudinal-regions
#12
Damanbha Lyngdoh, Sunil Sharma, Bishnupada Roy, Veena Tandon
The parasitic flukes of the genus Fasciola (Platyhelminthes: Trematoda: Digenea) cause fascioliasis or liver-rot disease in ruminant livestock in tropical and sub-tropical regions of the world. Classically, two species of Fasciola- F. hepatica and F. gigantica, are universally recognized as taxonomically valid species. Our survey studies on ovid and bovid animals including yak and mithun from high altitudinal mountainous regions in Northeast India revealed the occurrence of Fasciola gigantica and also Fasciola sp...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27884440/re-infection-with-fasciola-gigantica-6-month-post-treatment-with-triclabendazole-in-cattle-from-mobile-pastoralist-husbandry-systems-at-lake-chad
#13
Helena Greter, Annour A Batil, Idriss O Alfaroukh, Felix Grimm, Bongo N Ngandolo, Jennifer Keiser, Jürg Utzinger, Jakob Zinsstag, Jan Hattendorf
At Lake Chad in central Africa, livestock fascioliasis caused by Fasciola gigantica represents a major veterinary health problem, particularly in cattle reared in mobile pastoralist husbandry systems. We assessed re-infection after a single dose of triclabendazole with fascioliasis in cattle in a mobile pastoralist setting towards the end of the dry season. Within the cattle herds of 14 groups of mobile pastoralists, 375 cattle were randomly selected. A faecal sample was obtained from each animal to determine the prevalence of F...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27884436/distribution-of-foxp3-t-cells-in-the-liver-and-hepatic-lymph-nodes-of-goats-and-sheep-experimentally-infected-with-fasciola-hepatica
#14
A Escamilla, R Zafra, J Pérez, T N McNeilly, I L Pacheco, L Buffoni, F J Martínez-Moreno, V Molina-Hernández, A Martínez-Moreno
Foxp3 regulatory T cells (Tregs) are now considered to play a key role in modulation of immune responses during parasitic helminth infections. Immunomodulation is a key factor in Fasciola hepatica infection; however, the distribution and role of Foxp3(+) Tregs cells have not been investigated in F. hepatica infected ruminants. The aim of this study was to evaluate the presence of Foxp3(+) Tregs in the liver and hepatic lymph nodes from experimentally infected sheep and goats during acute and chronic stages of infection...
October 30, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27883079/a-parasite-derived-68-mer-peptide-ameliorates-autoimmune-disease-in-murine-models-of-type-1-diabetes-and-multiple-sclerosis
#15
Maria E Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T Hutchinson, Mark W Robinson, Ann M Simpson, Bronwyn A O'Brien, John P Dalton, Sheila Donnelly
Helminth parasites secrete molecules that potently modulate the immune responses of their hosts and, therefore, have potential for the treatment of immune-mediated human diseases. FhHDM-1, a 68-mer peptide secreted by the helminth parasite Fasciola hepatica, ameliorated disease in two different murine models of autoimmunity, type 1 diabetes and relapsing-remitting immune-mediated demyelination. Unexpectedly, FhHDM-1 treatment did not affect the proliferation of auto-antigen specific T cells or their production of cytokines...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876981/detection-of-fasciola-hepatica-and-fasciola-gigantica-common-and-uncommon-antigens-using-rabbit-hyper-immune-serum-raised-against-their-excretory-secretory-and-somatic-antigens
#16
S Abdolahi Khabisi, B Sarkari
Fasciolosis is an important neglected helminth disease caused by two liver flukes, Fasciola hepatica and Fasciola gigantica. The two species of Fasciola are usually different in their morphological and molecular features. They have also common and uncommon antigens in both their somatic and excretory secretory metabolites. In this study, we compared somatic and excretory-secretory (ES) antigens of F. hepatica and F. gigantica, by using rabbit hyper immune serum raised against these antigens. Adult worms were collected from bile ducts of infected animals and species of the fluke was confirmed by RFLP-PCR...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876956/comparison-between-in-house-indirect-elisa-and-dot-elisa-for-the-diagnosis-of-fasciola-gigantica-in-cattle
#17
Jafar Arjmand Yamchi, Nasser Hajipour, Seyyed Meysam Abtahi Froushani, Mojtaba Keighobadi
This survey was done to investigate the efficacy of the in-house indirect ELISA (iELISA) and Dot-ELISA methods Prepared from excretion-secretory (ES Ag) and Crude (Cr Ag) antigens of Fasciola for sero-diagnosis of Fasciola gigantica in cattle. The liver specimens of slaughtered cattle were collected and their liver examined macroscopically and microscopically for infestation to fasciolosis. Sera from two groups of cattle, one infected with fasciolosis (n = 60) and the other non-infected with fasciolosis (n = 60), were used in the iELISA and Dot-ELISA test; grouping based on histopathology results...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876944/seasonal-incidence-of-parasitic-diseases-in-bovines-of-south-western-gujarat-junagadh-india
#18
Binod Kumar, B R Maharana, Amit Prasad, Joice P Joseph, Bhavika Patel, J S Patel
The current study was conducted to investigate the incidence of parasitic diseases in bovines which were sick and brought at veterinary hospital for treatment. A total of 366 samples were investigated from cattle (n = 175) and buffaloes (n = 191) presented at Teaching Veterinary Clinical Complex (TVCC), Veterinary College, Junagadh, Gujarat during January to December 2014. Examination of Giemsa-stained peripheral blood smears exhibited that 58.6 % of cattle and 41.2 % of buffaloes were infected with haemoparasites comprising Babesia bigemina, Theileria annulata, and Anaplasma marginale @ of 54...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27876909/prevalence-of-gastrointestinal-parasites-in-bovines-in-and-around-junagadh-gujarat
#19
B R Maharana, Binod Kumar, N R Sudhakar, S K Behera, T K Patbandha
Coprological examination of 416 bovine faecal samples revealed the presence of parasitic stages of Toxocara vitulorum, strongyles, Strongyloides spp., Fasciola spp., amphistomes, coccidia (Eimeria spp. and Cryptosporidium spp.) and Buxtonella sulcata. About 42 % (n = 302) faecal samples from cattle and 36 % (n = 114) samples from buffaloes were positive for gastrointestinal (GI) parasitic infections. Both cattle (14.57 %) and buffalo (15.79 %) had the highest incidence of Buxtonella sulcata, respectively...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27866265/proteomic-analysis-of-fasciola-hepatica-excretory-and-secretory-products-fhesps-involved-in-interacting-with-host-pbmcs-and-cytokines-by-shotgun-lc-ms-ms
#20
Qing Liu, Si-Yang Huang, Dong-Mei Yue, Jin-Lei Wang, Yujian Wang, Xiangrui Li, Xing-Quan Zhu
Fasciola hepatica is a helminth parasite with a worldwide distribution, which can cause chronic liver disease, fasciolosis, leading to economic losses in the livestock and public health in many countries. Control is mostly reliant on the use of drugs, and as a result, drug resistance has now emerged. The identification of F. hepatica genes involved in interaction between the parasite and host immune system is utmost important to elucidate the evasion mechanisms of the parasite and develop more effective strategies against fasciolosis...
November 19, 2016: Parasitology Research
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