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Liposomal bupivacaine

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https://www.readbyqxmd.com/read/27924842/effects-of-liposomes-charge-on-extending-sciatic-nerve-blockade-of-n-ethyl-bromide-of-lidocaine-in-rats
#1
Qinqin Yin, Bowen Ke, Xiaobing Chen, Yikai Guan, Ping Feng, Guo Chen, Yi Kang, Wensheng Zhang, Yu Nie
N-methyl bromide of lidocaine (QX-314) is a potential local anaesthetic with compromised penetration through cell membranes due to its obligated positive charge. Liposomes have been widely used for drug delivery with promising efficacy and safety. Therefore we investigated the local anaesthetic effects and tissue reactions of QX-314 in combination with anionic, cationic or neutral liposomes in rat sciatic nerve block model, and explored the effects of these liposomes on cellular entry of QX-314 in human embryonic kidney 293 cells...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27909614/long-acting-liposomal-bupivacaine-decreases-inpatient-narcotic-requirements-in-men-undergoing-penile-prosthesis-implantation
#2
Brittney H Cotta, Charles Welliver, Anand Brahmamdam, Cynthia L Bednarchik, Danuta Dynda, Tobias S Köhler
OBJECTIVE: A new extended-release bupivacaine suspension bupivacaine (ERSB) delivers 3 days of local anesthetic and has been shown to reduce pain and narcotic usage in some patient groups but this issue is largely unstudied in urologic surgery. MATERIAL AND METHODS: We performed a single-surgeon retrospective chart review of the patients who underwent penile prosthesis implantation. Pain scores and standardized morphine equivalent (ME) dose data were collected during 23 hour- observation period...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27856385/wound-infiltration-with-extended-release-versus-short-acting-bupivacaine-before-laparoscopic-hysterectomy-a-randomized-controlled-trial
#3
Kenneth I Barron, Georgine M Lamvu, R Cole Schmidt, Matthew Fisk, Emily Blanton, Insiyyah Patanwala
STUDY OBJECTIVE: To evaluate if pre-incision infiltration with extended-release liposomal bupivacaine provides improved overall pain relief compared to 0.25% bupivacaine after laparoscopic or robotic-assisted hysterectomy. DESIGN: Single center double-masked randomized controlled trial (Canadian Task Force Classification I). SETTING: Tertiary-care community hospital PATIENTS: Patients recruited from July 2015 through January 2016. Sixty-four patients were randomized and 59 were analyzed for the primary outcome...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27856266/local-injection-of-liposomal-bupivacaine-combined-with-intravenous-dexamethasone-reduces-postoperative-pain-and-hospital-stay-after-shoulder-arthroplasty
#4
Howard D Routman, Logan R Israel, Molly A Moor, Andrew D Boltuch
BACKGROUND: Alternative techniques have been developed to address pain after shoulder arthroplasty and are well documented. We evaluated the effect of adding intraoperative liposomal bupivacaine and intravenous dexamethasone during shoulder arthroplasty. METHODS: We retrospectively reviewed 2 consecutive cohorts undergoing elective shoulder arthroplasty. The 24 patients in cohort 1 and the 31 patients in cohort 2 received perioperative multimodal management with preoperative and postoperative intravenous and oral narcotics, gabapentin, nonsteroidal anti-inflammatory drugs, acetaminophen, and single-injection interscalene block...
November 15, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27824434/a-randomized-multicenter-double-blind-study-of-local-infiltration-analgesia-with-liposomal-bupivacaine-for-postsurgical-pain-following-total-knee-arthroplasty-rationale-and-design-of-the-pillar-trial
#5
Stan Dysart, Mark A Snyder, Michael A Mont
INTRODUCTION: Liposomal bupivacaine, a prolonged-release formulation of bupivacaine hydrochloride, is indicated for infiltration into the surgical site for postsurgical analgesia. Results from previous total knee arthroplasty (TKA) studies suggest that analgesic efficacy associated with liposomal bupivacaine may be impacted by variability in infiltration technique. The PILLAR study is designed to assess liposomal bupivacaine efficacy in TKA using a standardized infiltration protocol. Materials and Methods/Design: This phase 4, multicenter, randomized, double-blind, controlled, parallel-group study will compare the safety and efficacy of infiltration with liposomal bupivacaine versus standard bupivacaine for postsurgical pain control in adults undergoing primary unilateral TKA...
November 11, 2016: Surgical Technology International
https://www.readbyqxmd.com/read/27769675/pain-reduction-in-untreated-symptomatic-irreversible-pulpitis-using-liposomal-bupivacaine-exparel-a-prospective-randomized-double-blind-trial
#6
Kristy Bultema, Sara Fowler, Melissa Drum, Al Reader, John Nusstein, Mike Beck
INTRODUCTION: In the treatment of patients with symptomatic irreversible pulpitis, endodontic debridement is a predictable method to relieve pain. However, there are clinical situations in which emergency care cannot be provided immediately. An unexplored treatment option in these cases may be the use of a long-acting anesthetic to reduce pain in untreated irreversible pulpitis. Some medical studies have shown potential for infiltrations of liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, San Diego, CA) to prolong pain relief and reduce opioid use postoperatively...
October 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27749354/continuous-peripheral-nerve-blocks-an-update-of-the-published-evidence-and-comparison-with-novel-alternative-analgesic-modalities
#7
Brian M Ilfeld
A continuous peripheral nerve block (CPNB) consists of a percutaneously inserted catheter with its tip adjacent to a target nerve/plexus through which local anesthetic may be administered, providing a prolonged block that may be titrated to the desired effect. In the decades after its first report in 1946, a plethora of data relating to CPNB was published, much of which was examined in a 2011 Anesthesia & Analgesia article. The current update is an evidence-based review of the CPNB literature published in the interim...
October 3, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27747127/a-content-incontinent-report-of-liposomal-bupivacaine-induced-fecal-incontinence
#8
Emanuel A Shapera, Vinay K Rai
Proper surgical management of anal fistula demands sound clinical judgment and extraordinary care to prevent incontinence and adequate postoperative pain control and provide satisfactory resolution to optimize quality of life. Fecal incontinence can be a devastating complication of procedures performed for fistula in ano. We report a unique case in which temporary incontinence (for less than 4 days) followed injection of liposomal bupivacaine for postoperative pain control after draining seton placement for fistula in ano...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27742564/liposomal-bupivacaine-infiltration-versus-femoral-nerve-block-for-pain-control-in-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#9
REVIEW
Jianbing Ma, Weijie Zhang, Shuxin Yao
OBJECTIVE: Total knee arthroplasty (TKA) usually results in postoperative pain. The objective of this meta-analysis was to compare the effectiveness and safety of liposomal bupivacaine (LB) infiltration and femoral nerve block (FNB) for pain control in total knee arthroplasty. METHODS: We systemically searched electronic databases, including Embase (1980-2016.7), MEDLINE (1966-2016.7), PubMed (1966-2016.7), ScienceDirect (1985-2016.7), Web of Science (1950-2016...
October 11, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27741199/abdominal-incision-injection-of-liposomal-bupivacaine-and-opioid-use-after-laparotomy-for-gynecologic-malignancies
#10
Eleftheria Kalogera, Jamie N Bakkum-Gamez, Amy L Weaver, James P Moriarty, Bijan J Borah, Carrie L Langstraat, Christopher J Jankowski, Jenna K Lovely, William A Cliby, Sean C Dowdy
OBJECTIVE: To investigate opioid use and pain scores associated with incisional injection of liposomal bupivacaine compared with bupivacaine hydrochloride after laparotomy for gynecologic malignancies. METHODS: A retrospective cohort study was conducted to compare abdominal incision infiltration with liposomal bupivacaine with bupivacaine hydrochloride after modification of a pre-existing enhanced recovery pathway. Patients undergoing staging laparotomy or complex cytoreductive surgery under the updated pathway were compared with patients treated under the original pathway (historic controls)...
November 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27732710/efficacy-of-liposomal-bupivacaine-infiltration-on-the-management-of-total-knee-arthroplasty
#11
Bryan Sakamoto, Shelly Keiser, Russell Meldrum, Gene Harker, Andrew Freese
Importance: Liposomal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltration in total knee arthroplasty (TKA). Athough liposomal bupivacaine is widely used, it is unknown if the benefits justify the cost in the veteran population at our institution. Objective: To evaluate a change in practice: the effect of local infiltration of liposomal bupivacaine on perioperative outcomes in patients undergoing primary TKA. Design, Setting, and Participants: A retrospective cohort study was conducted among patients who underwent primary TKA at a Veterans Affairs Medical Center before (March 3, 2013-March 2, 2014) and after (March 3, 2014-March 2, 2015) the implementation of liposomal bupivacaine for local infiltration in TKA...
October 12, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27679220/comparison-of-laparoscopically-assisted-transversus-abdominis-plane-block-using-liposomal-bupivacaine-with-pre-incisional-bupivacaine-for-post-operative-pain-control-in-patients-undergoing-laparoscopic-or-robotic-assisted-laparoscopic-hysterectomy-a-randomized
#12
https://www.readbyqxmd.com/read/27673545/systematic-review-of-liposomal-bupivacaine-exparel-for-postoperative-analgesia
#13
Krishna S Vyas, Sibi Rajendran, Shane D Morrison, Afaaf Shakir, Samir Mardini, Valerie Lemaine, Maurice Y Nahabedian, Stephen B Baker, Brian D Rinker, Henry C Vasconez
BACKGROUND: Management of postoperative pain often requires multimodal approaches. Suboptimal dosages of current therapies can leave patients experiencing periods of insufficient analgesia, often requiring rescue therapy. With absence of a validated and standardized approach to pain management, further refinement of treatment protocols and targeted therapeutics is needed. Liposomal bupivacaine (Exparel) is a longer acting form of traditional bupivacaine that delivers the drug by means of a multivesicular liposomal system...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27667533/periarticular-injection-of-liposomal-bupivacaine-offers-no-benefit-over-standard-bupivacaine-in-total-knee-arthroplasty-a-prospective-randomized-controlled-trial
#14
Pouya Alijanipour, Timothy L Tan, Christopher N Matthews, Jessica R Viola, James J Purtill, Richard H Rothman, Javad Parvizi, Matthew S Austin
BACKGROUND: Periarticular injection of liposomal bupivacaine has been adopted as part of multimodal pain management after total knee arthroplasty (TKA). METHODS: In this prospective, randomized clinical trial, we enrolled 162 patients undergoing primary TKA in a single institution between January 2014 and May 2015. Eighty-seven patients were randomized to liposomal bupivacaine (experimental group), and 75 patients were randomized to free bupivacaine (control group)...
August 9, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27648263/treatment-of-complex-regional-pain-syndrome-with-stellate-ganglion-local-anesthetic-blockade-a-case-report-of-one-patient-s-experiences-with-traditional-bupivacaine-hcl-and-liposome-bupivacaine
#15
Martin G Ferrillo
Complex regional pain syndrome (CRPS) is a poorly understood, debilitating disorder characterized by severe chronic pain in an affected limb or region of the body. This case presentation is the first to describe the effectiveness and prolonged duration of the effect of liposome bupivacaine in stellate ganglion block for CRPS.
September 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27558150/liposomal-bupivacaine-peripheral-nerve-block-for-the-management-of-postoperative-pain
#16
REVIEW
Thomas W Hamilton, Vassilis Athanassoglou, Marialena Trivella, Louise H Strickland, Stephen Mellon, David Murray, Hemant G Pandit
BACKGROUND: Postoperative pain remains a significant issue with poor perioperative pain management associated with an increased risk of morbidity and mortality. Liposomal bupivacaine is an analgesic consisting of bupivacaine hydrochloride encapsulated within multiple, non-concentric lipid bi-layers offering a novel method of sustained release. OBJECTIVES: To assess the analgesic efficacy and adverse effects of liposomal bupivacaine infiltration peripheral nerve block for the management of postoperative pain...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27531019/pilot-randomized-placebo-controlled-clinical-field-study-to-evaluate-the-effectiveness-of-bupivacaine-liposome-injectable-suspension-for-the-provision-of-post-surgical-analgesia-in-dogs-undergoing-stifle-surgery
#17
B Duncan X Lascelles, Lesley C Rausch-Derra, Jessica A Wofford, Margie Huebner
BACKGROUND: Local anesthetics are an important component of perioperative pain management, but the duration of action of available products is limited. We hypothesized that a single local infiltration of a novel bupivacaine liposome injectable suspension (AT-003) would provide clinically effective analgesia over a 72-h period. In a masked, randomized, placebo-controlled, multi-center pilot field study, dogs undergoing lateral retinacular suture placement for cranial cruciate insufficiency were randomly assigned to surgical site infiltration with AT-003 (5...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27505115/effectiveness-of-liposomal-bupivacaine-in-colorectal-surgery-a-pragmatic-nonsponsored-prospective-randomized-double-blinded-trial-in-a-community-hospital
#18
Rachel A Knudson, Paul W Dunlavy, Jan Franko, Shankar R Raman, Soren R Kraemer
BACKGROUND: Prior industry conducted studies have shown that long acting liposomal bupivacaine injection improves pain control postoperatively. OBJECTIVE: To evaluate whether liposomal bupivacaine reduced the use of postoperative opioid (http://links.lww.com/DCR/A253) pain medication as compared to standard bupivacaine following colorectal surgery. DESIGN: A double blinded, prospective, randomized controlled trial comparing liposomal bupivacaine versus standard bupivacaine in patients undergoing elective colon resection...
September 2016: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27461787/does-liposomal-bupivacaine-exparel-significantly-reduce-postoperative-pain-numbness-in-symptomatic-teeth-with%C3%A2-a%C3%A2-diagnosis-of-necrosis-a-prospective-randomized-double-blind-trial
#19
Brandon Glenn, Melissa Drum, Al Reader, Sara Fowler, John Nusstein, Mike Beck
INTRODUCTION: Medical studies have shown some potential for infiltrations of liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, San Diego, CA), a slow-release bupivacaine solution, to extend postoperative benefits of numbness/pain relief for up to several days. Because the Food and Drug Administration has approved Exparel only for infiltrations, we wanted to evaluate if it would be effective as an infiltration to control postoperative pain. The purpose of this study was to compare an infiltration of bupivacaine with liposomal bupivacaine for postoperative numbness and pain in symptomatic patients diagnosed with pulpal necrosis experiencing moderate to severe preoperative pain...
September 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27444032/corr-insights-%C3%A2-no-difference-in-early-analgesia-between-liposomal-bupivacaine-injection-and-intrathecal-morphine-after-tka
#20
Philippe Richebé, Véronique Brulotte
No abstract text is available yet for this article.
July 21, 2016: Clinical Orthopaedics and related Research
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