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https://www.readbyqxmd.com/read/29453468/prevention-of-shivering-during-spinal-anesthesia-comparison-between-tramadol-ketamine-and-ondansetron
#1
Gajal Lakhe, Krishna Murari Adhikari, Kiran Khatri, Anil Maharjan, Akriti Bajracharya, Himdip Khanal
INTRODUCTION: Shivering is an unpleasant experience after spinal anesthesia. We conducted this study to evaluate the efficacy of ondansetron, ketamine and tramadol for prevention of shivering. METHODS: In this randomized controlled study, 120 patients aged 18-65 years of American Society of Anesthesiologist (ASA) physical status I and II undergoing various surgical procedures were included and allocated alternately to one of the 4 groups; Normal saline (Group1), Ondansetron 4mg (Group2), Ketamine 0...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29452834/pain-and-analgesic-drugs-in-chronic-venous-ulcers-with-topical-sevoflurane-use
#2
Adrian Imbernon-Moya, Francisco Javier Ortiz-de Frutos, Mónica Sanjuan-Alvarez, Isabel Portero-Sanchez, Raúl Merinero-Palomares, Victoria Alcazar
OBJECTIVE: Pain in chronic venous ulcers (CVUs) notably increases with the usual cleaning of the wound. Chronic pain is usually poorly controlled even with the multiple analgesic treatments available. Analgesics can have different serious adverse effects and medical interactions in old patients with several comorbidities. This study reports the efficacy and safety of topical sevoflurane for treatment of pain in CVUs. METHODS: We report a descriptive and retrospective study of 30 patients older than 65 years with painful CVUs refractory to conventional analgesic treatments...
February 13, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29433564/high-dose-thiotepa-related-neurotoxicity-and-the-role-of-tramadol-in-children
#3
Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet, Christelle Dufour
BACKGROUND: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to high-dose thiotepa and to identify potential contributing factors that could exacerbate the occurrence of this neurotoxicity. METHODS: From May 1987 to March 2011, children with solid tumours treated with high-dose thiotepa were retrospectively identified...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29429391/comparative-effectiveness-of-oral-pharmacologic-interventions-for-knee-osteoarthritis-a-network-meta-analysis
#4
Sun-Young Jung, Eun Jin Jang, Seoung Wan Nam, Hyuk Hee Kwon, Seul Gi Im, Dam Kim, Soo-Kyung Cho, Dalho Kim, Yoon-Kyoung Sung
OBJECTIVES: To explore the relative efficacy of oral pharmacologic interventions in the treatment of knee OA. METHODS: A systematic literature review was conducted using the MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases to identify trials conducted in patients with knee OA with a minimum 6 weeks of follow-up. The standardized mean differences of the change from baseline to week 6 in Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain between the treatment groups were estimated using Bayesian random-effects network meta-analyses...
February 12, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29427348/the-effect-of-tramadol-on-sneeze-induced-urethral-continence-reflex-through-%C3%AE-opioid-receptors-in-the-spinal-cord-in-rats
#5
Asuka Ashikari, Minoru Miyazato, Ryu Kimura, Takuma Oshiro, Seiichi Saito
AIMS: We examined the efficacy of tramadol on the urethral reflex during sneezing, as well as the role of µ-opioid receptors in the spinal cord, in rats. METHODS: Forty-one female Sprague-Dawley rats were used. The rats were divided into normal female rats and rats with vaginal distension (VD), which mimics stress urinary incontinence (SUI) in humans. Under urethane anesthesia, the sneeze-induced amplitude of urethral responses (AUR) and baseline pressure (BP) were examined after intravenous injection of tramadol using a microtransducer-tipped catheter in both rat groups...
February 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29416862/tramadol-sparing-effect-of-dexmedetomidine-as-an-adjuvant-with-lignocaine-in-preoperative-stellate-ganglion-block-for-postoperative-pain-relief-following-upper-limb-surgeries
#6
Deepak Thapa, Deepanshu Dhiman, Vanita Ahuja, Satinder Gombar, Ravi K Gupta
Background: Recent literature has established the role of stellate ganglion block (SGB) for management of acute postoperative pain. The effects of dexmedetomidine as an adjuvant to lignocaine in a preoperative SGB for postoperative pain relief have not been evaluated so far. Methods: The following randomised, double-blinded, control trail included 54 patients scheduled for upper limb orthopaedic surgery under general anaesthesia. Preoperative ultrasound-guided (USG) SGB was performed in all patients...
February 2018: British Journal of Pain
https://www.readbyqxmd.com/read/29416258/tramadol-induced-hypoglycemia-an-unusual-adverse-effect
#7
Subramanian Senthilkumaran, Chidambaram Ananth, Ritesh G Menezes, Ponniah Thirumalaikolundusubramanian
No abstract text is available yet for this article.
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29412051/prehospital-analgesia-for-pediatric-trauma-patients-in-iraq-and-afghanistan
#8
Steven G Schauer, Allyson A Arana, Jason F Naylor, Guyon J Hill, Michael D April
BACKGROUND: Previous studies have evaluated prehospital analgesia during combat operations in Iraq and Afghanistan, but were limited to the adult population. However, a significant portion of the casualties of those conflicts were children. We describe the prehospital analgesia administered to wartime pediatric trauma patients. METHODS: We queried the Department of Defense Trauma Registry (DODTR) for all pediatric patients (<18 years of age) admitted to United States and Coalition fixed-facility hospitals in Iraq and Afghanistan from January 2007 to January 2016...
February 7, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29406179/disambiguating-pharmacological-mechanisms-from-placebo-in-neuropathic-pain-using-functional-neuroimaging
#9
V Wanigasekera, K Wartolowska, J P Huggins, E P Duff, W Vennart, M Whitlock, N Massat, L Pauer, P Rogers, B Hoggart, I Tracey
BACKGROUND: A lack of objective outcome measures and overreliance on subjective pain reports in early proof-of-concept studies contribute to the high attrition of potentially effective new analgesics. We studied the utility of neuroimaging in providing objective evidence of neural activity related to drug modulation or a placebo effect in a double-blind, randomized, placebo-controlled, three-way crossover trial. METHODS: We chronically administered pregabalin or tramadol (first-line and second-line analgesics, respectively), recommended for neuropathic pain, in 16 post-traumatic neuropathic pain patients...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29402712/patients-at-risk-preoperative-opioid-use-affects-opioid-prescribing-refills-and-outcomes-after-total-knee-arthroplasty
#10
Nicholas M Hernandez, Joshua A Parry, Tad M Mabry, Michael J Taunton
BACKGROUND: The purpose of this study was to evaluate the effect of preoperative opioid use on opioid prescriptions, refills, and clinical outcomes after total knee arthroplasty (TKA). METHODS: A retrospective review identified 53 patients on preoperative opioids who were matched 1:2 to 106 opioid-naive patients undergoing primary TKA with at least 2-year follow-up. Opioid refills, Knee Society Score (preoperative and follow-up), morphine equivalent dose (MED) prescribed, and persistent opioid use were compared between groups...
January 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29393998/prevention-and-treatment-of-postoperative-pain-after-lumbar-spine-procedures-a-systematic-review
#11
REVIEW
Sergio Terracina, Chiara Robba, Anna Prete, Paola G Sergi, Federico Bilotta
BACKGROUND AND OBJECTIVE: In the last decades, in developed countries, spine procedures (surgical and percutaneous) had the highest absolute increase in case volume trend. Optimal approach to prevent and treat postoperative pain is continuously evolving. This systematic literature review presents evidence on safety and efficacy of pharmacological and non-pharmacological therapies to prevent and treat postoperative pain after lumbar spine procedures. DATABASES AND DATA TREATMENT: Publications listed in PUBMED and EMBASE were considered to identify randomized clinical trials suitable for inclusion in this systematic review...
February 2, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29393818/comparison-of-intraperitoneal-nebulization-of-ropivacaine-with-ropivacaine-fentanyl-combination-for-pain-control-following-laparoscopic-cholecystectomy-a-randomized-double-blind-placebo-controlled-trial
#12
Nidhi Bhatia, Swati Mehta, Vikas Saini, Babita Ghai, Lileshwar Kaman
PURPOSE: Intraperitoneal local anesthetic nebulization is a new and novel technique for providing pain relief following laparoscopic cholecystectomy. We compared the analgesic efficacy of intraperitoneal ropivacaine-fentanyl nebulization with ropivacaine nebulization alone for providing pain relief following laparoscopic cholecystectomy Materials and Methods: This prospective, randomized, double-blind, placebo-controlled trial included 75 American Society of Anesthesiologists I/II patients, 18-60 years old, scheduled to undergo laparoscopic cholecystectomy under general anesthesia...
February 2, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29393744/lack-of-effectiveness-of-tramadol-hydrochloride-for-the-treatment-of-pain-and-joint-dysfunction-in-dogs-with-chronic-osteoarthritis
#13
Steven C Budsberg, Bryan T Torres, Stephanie A Kleine, Gabriella S Sandberg, Amanda K Berjeski
OBJECTIVE To investigate the effectiveness of tramadol for treatment of osteoarthritis in dogs. DESIGN Randomized, blinded, placebo-controlled crossover study. ANIMALS 40 dogs with clinical osteoarthritis of the elbow or stifle joint. PROCEDURES Dogs orally received 3 times/d (morning, midday, and night) for a 10-day period each of 3 identically appearing treatments (placebo; carprofen at 2.2 mg/kg [1 mg/lb], q 12 h [morning and night], with placebo at midday; or tramadol hydrochloride at 5 mg/kg [2.3 mg/lb], q 8 h) in random order, with treatment sessions separated by a minimum 7-day washout period...
February 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29391825/tramadol-use-in-a-patient-with-brugada-syndrome-and-morphine-allergy-a-case-report
#14
Cengiz Sahutoglu, Seden Kocabas, Fatma Zekiye Askar
Brugada syndrome is a rare syndrome characterized by arrhythmias and sudden death, particularly in younger individuals. A mutation in a gene encoding the human cardiac sodium channels is responsible for this syndrome. In the literature, there are several case reports of Brugada syndrome in association with the use of several anesthetic agents. Herein, we present our anesthetic practice and the use of tramadol in a 75-year-old female patient who underwent pulmonary lobectomy under general anesthesia and was diagnosed with Brugada syndrome...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29378991/postoperative-analgesia-using-bupivacaine-wound-infiltration-with-intravenous-tramadol-or-dexamethasone-following-obstetric-spinal-anaesthesia
#15
N P Edomwonyi, M O Osazuwa, O I Iribhogbe, S E Esangbedo
CONTEXT: Effective management of postcesarean section (CS) pain is important for the well-being of mother and child; even in limited-resource areas, there are drug options which can be explored to achieve this. AIM: This study aimed to compare the analgesic effects of a combination of bupivacaine wound infiltration with either intravenous (IV) dexamethasone or tramadol after CS. SETTING AND DESIGN: This study was a randomized, double-blind, comparative study in a tertiary hospital...
December 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29376494/antiarthritic-effect-of-polar-extract-of-curcuma-longa-on-monosodium-iodoacetate-induced-osteoarthritis-in-rats
#16
Sasikumar Murugan, Bharathi Bethapudi, Divya Purusothaman, Prasanna Raja, Chandrasekaran Chinampudur Velusami
BACKGROUND: Curcuma longa Linn, "the golden spice" is a common spice used in southern Asia and Middle East countries. It has a history of ethnopharmacological use for its various functional activities like antiseptic, anti-inflammatory, antioxidant, antimicrobial, anticancer and so on. OBJECTIVE: To investigate the effects of polar extract of C. longa (PCL) against monosodium iodoacetate (MIA) induced osteoarthritis in rat and to compare with curcuminoids, which are contemporarily believed to be the only active phytochemicals of C...
January 26, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29369473/comparative-pharmacology-and-toxicology-of-tramadol-and-tapentadol
#17
REVIEW
J Faria, J Barbosa, R Moreira, O Queirós, F Carvalho, R J Dinis-Oliveira
BACKGROUND AND OBJECTIVE: Moderate to severe pain represent a heavy burden in patients' quality of life, and ultimately in the society and in healthcare costs. The aim of this review was to summarize data on tramadol and tapentadol adverse effects, toxicity, potential advantages and limitations according to the context of clinical use. DATABASES AND DATA TREATMENT: We compared data on the pharmacological and toxicological profiles of tramadol and tapentadol, after an extensive literature search in the U...
January 25, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29361312/the-usefulness-of-interpectoral-block-as-an-analgesic-technique-in-breast-cancer-surgery
#18
R Ortiz de la Tabla González, P Gómez Reja, D Moreno Rey, C Pérez Naranjo, I Sánchez Martín, M Echevarría Moreno
OBJECTIVE: To compare the analgesic efficacy of continuous interpectoral block (CIPB) compared to intravenous analgesia (IV) after breast surgery. MATERIAL AND METHOD: A prospective, comparative and randomised study of women aged from 18-75years, ASAI-III, operated for breast cancer. In group1 (CIPB) after general anaesthetic, an ultrasound-guided interpectoral catheter was placed and 30mL of 0.5% ropivacaine was administered through it. In the event of an increase in heart rate and blood pressure >15% after the surgical incision, intravenous fentanyl 1μg·kg-1 was administered, repeating the dose as necessary...
January 17, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29354587/botulinum-toxin-type-a-injection-for-neuropathic-pain-in-a-patient-with-a-brain-tumor-a-case-report
#19
Kyung Eun Nam, Joon Sung Kim, Bo Young Hong, Bomi Sul, Hyehoon Choi, So Yeon Jun, Seong Hoon Lim
Neuropathic pain is usually managed pharmacologically, rather than with botulinum toxin type A (BTX-A). However, medications commonly fail to relieve pain effectively or have intolerable side effects. We present the case of a 62-year-old man diagnosed with an intracranial chondrosarcoma, which was removed surgically and treated with radiation therapy. He suffered from neuropathic pain despite combined pharmacological therapy with gabapentin, amitriptyline, tramadol, diazepam, and duloxetine because of adverse effects...
December 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29344826/phytochemical-analysis-and-evaluation-of-the-antioxidant-anti-inflammatory-and-antinociceptive-potential-of-phlorotannin-rich-fractions-from-three-mediterranean-brown-seaweeds
#20
Amal Abdelhamid, Meriem Jouini, Haifa Bel Haj Amor, Zeineb Mzoughi, Mehdi Dridi, Rafik Ben Said, Abderrahman Bouraoui
Phlorotannins, phenolic compounds produced exclusively by seaweeds, have been reported to possess various pharmacological properties. However, there have been few works on these compounds from Mediterranean seaweeds. In this study, we investigated the phytochemical analysis and pharmacological potential of phlorotannin-rich fractions from three brown seaweeds collected along the Tunisia coast: Cystoseira sedoides (PHT-SED), Cladostephus spongeosis (PHT-CLAD), and Padina pavonica (PHT-PAD). Phytochemical determinations showed considerable differences in total phenolic content (TPC) and phlorotannin content (PHT)...
January 18, 2018: Marine Biotechnology
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