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https://www.readbyqxmd.com/read/29033355/evaluation-of-the-effect-of-serratus-anterior-plane-block-for-pain-treatment-after-video-assisted-thoracoscopic-surgery
#1
Korgun Okmen, Burcu Metin Okmen
BACKGROUND: Analgesia following video-assisted thoracoscopic surgery (VATS) is important for the prevention of postoperative pulmonary complications. Various regional methods of anaesthesia are currently being used to achieve this goal. In our study, we aim to assess the effectiveness of SAPB on postoperative VATS analgesia in our study. METHODS: A total of 40 patients aged between 18 and 70 years, those who were in the Society of Anaesthesiologists (ASA) I-III class and underwent VATS were included in the study...
October 12, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29028417/opioid-prescription-trends-among-patients-with-cancer-referred-to-outpatient-palliative-care-over-a-6-year-period
#2
Ali Haider, Donna S Zhukovsky, Yee Choon Meng, Joseph Baidoo, Kimberson C Tanco, Holly A Stewart, Tonya Edwards, Manju P Joy, Leela Kuriakose, Zhanni Lu, Janet L Williams, Diane D Liu, Eduardo Bruera
INTRODUCTION: In the United States, opioid regulations have become increasingly stringent in recent years. Increased regulatory scrutiny, in part, is related to heightened awareness through literature and a recent media blitz on the opioid prescription epidemic. These regulations have the potential to impact prescription trends by health care providers. Our objective was to evaluate changes in the type and dose of opioid prescriptions among patients who are referred by oncologists to an outpatient palliative care clinic...
October 13, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29027194/predictive-performance-of-physiologically-based-pharmacokinetic-pbpk-modeling-of-drugs-extensively-metabolized-by-major-cytochrome-p450s-in-children
#3
Wangda Zhou, Trevor N Johnson, Khanh H Bui, S Y Amy Cheung, Jianguo Li, Hongmei Xu, Nidal Al-Huniti, Diansong Zhou
The accuracy of physiologically-based pharmacokinetic (PBPK) model prediction in children, especially those younger than 2 years old has not been systematically evaluated. The aim of this study was to characterize the pediatric predictive performance of the PBPK approach for ten drugs extensively metabolized by CYP1A2 (theophylline), CYP2C8 (desloratidine, montelukast), CYP2C9 (diclofenac), CYP2C19 (esomeprazole, lansoprazole), CYP2D6 (tramadol) and CYP3A4 (itraconazole, ondansetron, sufentanil). Model performance in children was evaluated by comparing simulated plasma concentration-time profiles with observed clinical results for each drug and age group...
October 13, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29024536/etanercept-induced-lymphocytic-infiltration-of-jessner-kanof
#4
Noémie Abbad, Tristan Lanal, Céline Brenuchon, Gauthier Morel, Xavier Deprez
The patient, a 52-year-old man presented a two-week history of asymptomatic multiple erythematous papules on the upper back (Panel A). The skin lesion had arisen 3 weeks after starting therapy with etanercept for axial spondyloarthritis. For several months, the patient had been taking NSAI and tramadol. A biopsy specimen from a lesion revealed a dense lymphocytic infiltrate of the superficial and mid-dermis (arrow) with perivascular and perifollicular distribution (Panel B). This article is protected by copyright...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28987074/combination-of-rheum-ribes-and-metformin-against-diabetes-thermal-hyperalgesia-and-tactile-allodynia-in-a-mice-model
#5
Karim Raafat, Abdalla El-Lakany
Context • The prevalence of diabetes mellitus (DM) is increasing. Because of its progressive nature, therapeutic shifts and combinations are often required to reduce the risk of glucose toxicity and avoid serious side effects. To treat DM and its related complications, a combination therapy may offer a promising remedy to counteract those issues. Objectives • The study was established to evaluate the phytochemical content of a standardized aqueous extract of Rheum ribes (RR) and to determine the antidiabetic, antihyperalgesic, and antimechanical allodynic effects of 50 mg/kg of RR alone, 25 mg/kg of metformin (MTF) alone, and a combination of the 2 substances (MTF+RR) in mice with alloxan-induced diabetes...
October 2, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28977743/uptake-and-metabolism-of-human-pharmaceuticals-by-fish-a-case-study-with-the-opioid-analgesic-tramadol
#6
Rumi Tanoue, Luigi Margiotta-Casaluci, Belinda Huerta, Tamsin J Runnalls, Kei Nomiyama, Tatsuya Kunisue, Shinsuke Tanabe, John P Sumpter
Recent species-extrapolation approaches to predict the potential effects of pharmaceuticals present in the environment on wild fish are based on the assumption that pharmacokinetics and metabolism in humans and fish are comparable. To test this hypothesis, we exposed fathead minnows to the opiate pro-drug tramadol and examined uptake from the water into the blood and brain, and metabolism of the drug into its main metabolites. We found that plasma concentrations could be predicted reasonably accurately based on the lipophilicity of the drug, once the pH of the water was taken into account...
October 4, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28974843/characteristics-and-treatment-of-breakthrought-pain-btcp-in-palliative-care
#7
Samir Husic, Semir Imamovic, Srecko Matic, Aziz Sukalo
INTRODUCTION: This research was to follow characteristics of breakthrough pain caused by cancer (BTcP) and other most common sympthoms (ESAS) at patients in advanced stage of cancer disease in palliative care. PATIENTS AND METHODS: Prospective study included 433 patients which were treated in Palliative Care Centre in UKC Tuzla, Bosnia and Herzegovina. Group 1 was consisted of 353 patients whose basal cancer pain of intensity 4-7 NRS was treated weak opiates (basal analgetic- fixed combination of tramadol/paracetamol (37...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28969013/low-dose-of-dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-cesarean-surgery-provides-better-intraoperative-somato-visceral-sensory-block-characteristics-and-postoperative-analgesia
#8
Yong-Hong Bi, Xiao-Guang Cui, Rui-Qin Zhang, Chun-Yu Song, Yan-Zhuo Zhang
OBJECT: In this study, we aimed to investigate the beneficial effects of dexmedetomidine on somato-visceral sensory block characteristcs, postoperative analgesia and stress response of intrathecal bupivacaine administration in women undergoing cesarean section, and to find out which dose is better. METHODS: Sixty parturients with the American Society of Anesthesiologists (ASA) physical status I or II were anesthetized with intrathecal bupivacaine(10mg) alone or in combination with dexmedetomidine (3 μg and 5 μg) to undergo cesarean section...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28965648/nurse-practitioner-led-pain-management-the-day-after-caesarean-section-a-randomised-controlled-trial-and-follow-up-study
#9
Anthony Schoenwald, Carol Windsor, Edward Gosden, Clint Douglas
BACKGROUND: Pain on the day after caesarean section is often treated with controlled-release oxycodone to supplement the decline in analgesia from intrathecal opioids. Evidence suggests that caesarean birth is a biopsychosocial experience where a comprehensive approach is needed that promotes control and participation in pain management. OBJECTIVES: This study compared immediate-release oxycodone integrated with supportive educational strategies to controlled-release oxycodone...
September 1, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28964282/adherence-to-swedish-guidelines-for-pain-treatment-in-relation-to-pediatric-tonsil-surgery-a-survey-of-the-multidisciplinary-team
#10
F Alm, M Jaensson, S Lundeberg, E Ericsson
BACKGROUND: Pain management in children after tonsil surgery is essential, and optimal pain treatment has been discussed for many years. Data from the National Tonsil Register in Sweden (NTRS) and a national mapping have demonstrated the need for national pain treatment guidelines for pediatric tonsil surgery. As a result, Swedish national guidelines, together with updated patient information on the website tonsilloperation.se, were developed and implemented in 2013. OBJECTIVES: The objective of this study was to evaluate the professionals' opinions of and adherence to pain treatment guidelines for pediatric tonsil surgery patients in a two-year follow-up...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28955004/successful-treatment-of-mixed-mainly-cancer-pain-by-tramadol-preparations
#11
Shinji Kawahito, Tomohiro Soga, Naoji Mita, Shiho Satomi, Hiroyuki Kinoshita, Tomoko Arase, Akira Kondo, Hitoshi Miki, Kazumi Takaishi, Hiroshi Kitahata
The patient, a 70-year-old Japanese woman diagnosed with parotid gland cancer, underwent wide excision and reconstruction (facial nerve ablation, nerve transposition). At 1 month after the surgery, she was brought to our hospital's pain medicine department because her postoperative pain and cancer-related pain were poorly controlled. She had already been prescribed a tramadol (37.5 mg)/acetaminophen (325 mg) combination tablet (5 tablets/day). However, in addition to the continuous pain in her face and lower limbs, she was troubled by a trigeminal neuralgia-like prominence ache...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28953949/effect-of-tramadol-as-an-adjuvant-to-local-anesthetics-for-brachial-plexus-block-a-systematic-review-and-meta-analysis
#12
Hye Won Shin, Bum Jun Ju, Yoo Kyung Jang, Hae Seun You, Hyun Kang, Ji Yong Park
BACKGROUND: Tramadol, a 4-phenyl-piperidine analog of codeine, has a unique action in that it has a central opioidergic, noradrenergic, serotonergic analgesic, and peripheral local anesthetic (LA) effect. Many studies have reported contradictory findings regarding the peripheral analgesic effect of tramadol as an adjuvant to LA in brachial plexus block (BPB). This meta-analysis aimed to evaluate the effects of tramadol as an adjunct to LA in BPB during shoulder or upper extremity surgery...
2017: PloS One
https://www.readbyqxmd.com/read/28953472/laboratory-and-full-scale-studies-on-the-removal-of-pharmaceuticals-in-an-aerated-constructed-wetland-effects-of-aeration-and-hydraulic-retention-time-on-the-removal-efficiency-and-assessment-of-the-aquatic-risk
#13
Hannele Auvinen, Wilhelm Gebhardt, Volker Linnemann, Gijs Du Laing, Diederik P L Rousseau
Pharmaceutical residues in wastewater pose a challenge to wastewater treatment technologies. Constructed wetlands (CWs) are common wastewater treatment systems in rural areas and they discharge often in small water courses in which the ecology can be adversely affected by the discharged pharmaceuticals. Hence, there is a need for studies aiming to improve the removal of pharmaceuticals in CWs. In this study, the performance of a full-scale aerated sub-surface flow hybrid CW treating wastewater from a healthcare facility was studied in terms of common water parameters and pharmaceutical removal...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28950819/developmental-pharmacokinetics-in-neonates-maturational-changes-and-beyond
#14
Karel Allegaert, Paola Mian, John van den Anker
BACKGROUND: Effective and safe pharmacotherapy in an individual neonate necessitates understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a specific drug together with the characteristics of this neonate. METHODS: Developmental PK hereby provides estimates of the concentration-time profile. Multiple maturational, disease and treatment related differences can result in differences in PK and probably also in PD in neonates compared to other populations...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28950389/design-and-evaluation-of-chronomodulated-drug-delivery-of-tramadol-hydrochloride
#15
Thota Alekya, Dudhipala Narendar, Donthi Mahipal, Narala Arjun, Banala Nagaraj
Rheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100...
September 26, 2017: Drug Research
https://www.readbyqxmd.com/read/28944519/a-15-year-overview-of-increasing-tramadol-utilisation-and-associated-mortality-and-the-impact-of-tramadol-classification-in-the-united-kingdom
#16
Teng-Chou Chen, Li-Chia Chen, Roger David Knaggs
PURPOSE: This study aimed to develop hypotheses to explain the increasing tramadol utilisation, evaluate the impact of tramadol classification, and explore the trend between tramadol utilisation and related deaths in the United Kingdom. METHODS: This cross-sectional study used individual patient data, the Clinical Practice Research Datalink from 1993 to 2015, to calculate monthly defined daily dose (DDD)/1000 registrants, monthly prevalence and incidence of tramadol users, annual supply days, and mean daily dose of tramadol...
September 24, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28943040/treatment-of-musculo-skeletal-pain-in-haemophilia
#17
REVIEW
E Carlos Rodriguez-Merchan
Musculo-skeletal pain treatment is inadequate in many haemophilic patients. Analgesics are used only by 36% of adult patients. FVIII/FIX intravenous infusion is mainly used to lessen pain, followed in frequency by usage of NSAIDS (primarily COX-2 inhibitors). In about 30% of patients, pain continues after infusion of F VIII/IX. In acute haemarthroses pain treatment must continue until total disappearance (checked by ultrasonography) and include haematologic treatment, short-term rest of the involved joint, cryotherapy, joint aspiration and analgesic medication (paracetamol in mild pain, metamizole for more intense pain, and in a few precise patients, soft opioids such as codeine or tramadol)...
September 19, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28940476/impact-of-cyp2d6-functional-allelic-variations-on-phenoconversion-and-drug-drug-interactions
#18
F Storelli, A Matthey, S Lenglet, A Thomas, J Desmeules, Y Daali
We investigated whether CYP2D6 extensive metabolizers (EM) carrying a non-functional allele are at higher risk of phenoconversion to poor metabolizers in presence of CYP2D6 inhibitors. Seventeen homozygous carriers of two fully-functional alleles and seventeen heterozygous carriers of one fully-functional and one non-functional allele participated in this trial. Dextromethorphan 5mg and tramadol 10mg were given at each of the three study sessions. CYP2D6 was inhibited by duloxetine 60mg (session 2) and paroxetine 20mg (session 3)...
September 23, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28939321/ultrasound-guided-interscalene-brachial-plexus-nerve-block-with-an-ultralow-volume-of-local-anesthetic-for-post-thoracotomy-shoulder-girdle-pain
#19
Theodosios Saranteas, Anastasia Alevizou, Tatiana Sidiropoulou, Andreas Mavrogenis, Periklis Tomos, Panagiota Florou, Thomas Papadimos, Georgia Kostopanagiotou
OBJECTIVES: To evaluate the efficacy of ultrasound-guided interscalene nerve block using an ultralow volume of local anesthetic (5 mL of ropivacaine, 0.75%) for the management of post-thoracotomy shoulder girdle pain. DESIGN: Open-cohort, prospective, single-center study. SETTING: University hospital. INTERVENTIONS: Patients with post-thoracotomy shoulder girdle pain (visual analog scale [VAS] ≥5) received an ultrasound-guided interscalene nerve block...
April 26, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28936080/maintainence-treatment-of-opioid-dependence-with-tramadol
#20
Siddharth Sarkar, Mohit Varshney, Vaibhav Patil, Rakesh Lal
BACKGROUND: Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients with opioid dependence who were treated with tramadol for long-term maintenance. METHODS: Patients with opioid dependence who received treatment at the National Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New Delhi, were included in the study...
August 2017: Journal of Neurosciences in Rural Practice
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