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https://www.readbyqxmd.com/read/29932927/administration-of-a-co-crystal-of-tramadol-and-celecoxib-in-a-1-1-molecular-ratio-produces-synergistic-antinociceptive-effects-in-a-postoperative-pain-model-in-rats
#1
Manuel Merlos, Enrique Portillo-Salido, Alex Brenchat, Bertrand Aubel, Jordi Buxens, Angels Fisas, Xavier Codony, Luz Romero, Daniel Zamanillo, José Miguel Vela
Drug combination for the treatment of pain is common clinical practice. Co-crystal of Tramadol-Celecoxib (CTC) consists of two active pharmaceutical ingredients (APIs), namely the atypical opioid tramadol and the preferential cyclooxygenase-2 inhibitor celecoxib, at a 1:1 molecular ratio. In this study, a non-formulated 'raw' form of CTC administered in suspension (referred to as ctcsusp ) was compared with both tramadol and celecoxib alone in a rat plantar incision postoperative pain model. For comparison, the strong opioids morphine and oxycodone, and a tramadol plus acetaminophen combination at a molecular ratio of 1:17 were also tested...
June 19, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#2
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29929169/ultrasound-guided-posterior-quadratus-lumborum-block-for-postoperative-pain-after-laparoscopic-cholecystectomy-a-randomized-controlled-double-blind-study
#3
Korgün Ökmen, Burcu Metin Ökmen, Serra Topal
STUDY OBJECTIVE: Laparoscopic techniques are commonly used in surgical operations of the gallbladder. There are very few regional anesthesia methods used to achieve this goal. We aimed to investigate the effect of ultrasound-guided posterior quadratus lumborum block (QLB), administered bilaterally on pain scores after laparoscopic cholecystectomy operations. DESIGN: Prospective, double blind, randomized controlled clinical trial. SETTING: Single-institution, tertiary hospital...
June 18, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29926998/prescription-of-pain-medication-in-prisons-a-comparative-analysis-of-younger-and-older-male-prisoners
#4
Beatrice Annaheim, Wiebke Bretschneider, Violet Handtke, Angelo Belardi, Bernice S Elger
PURPOSE: In prison populations, treating pain is particularly challenging, especially for the growing number of older prisoners. The objective was to find out about prevalence, frequency, and types of pain medications prescribed to older prisoners (≥50 years) in comparison with younger prisoners (<50 years). METHODS: Data were collected in Switzerland as part of a study on ageing prisoners' health. Fifteen prisons (out of 26 of the total eligible population) agreed to take part, and data from medical records of 190 older and 190 younger male prisoners were analysed...
June 21, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29922476/antibacterial-effect-of-tramadol-against-staphylococcus-aureus-and-pseudomonas-aeruginosa-an-in-vivo-study
#5
H Farzam, A Farahani, A Tafkik, A Gorgin Karaji, P Mohajeri, M Rezaei, F Jalalvandi
Some important adverse effects of local and regional anaesthesia including injection-site infection, epidural abscess and meningitis, are usually caused by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. These infections can even cause the patient's death in severe cases. In the present study, the antimicrobial activity of tramadol was investigated on S. aureus and P. aeruginosa in BALB/c-sensitive mice. This experimental multigroup research study evaluated the effect of two different concentrations of injectable tramadol (12...
July 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29921893/pharmacological-interventions-for-premature-ejaculation-a-mixed-treatment-comparison-network-meta-analysis-of-randomized-clinical-trials
#6
Kannan Sridharan, Gowri Sivaramakrishnan, Reginald P Sequeira, Khalid Aj Al-Khaja
Premature ejaculation (PE) is the most common sexual dysfunction in men. The present study is a network meta-analysis of drugs used for treating PE. Electronic databases were searched for randomized controlled trials comparing medical interventions with either placebo or with other active drugs in patients with PE. Inverse variance heterogeneity model was used for mixed-treatment comparisons. Intravaginal ejaculatory latency time (IELT) and adverse events were the main outcome measures. A total of 44 studies were included in the meta-analysis...
June 20, 2018: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29916863/parasympathetic-tone-activity-evaluation-to-discriminate-ketorolac-and-ketorolac-tramadol-analgesia-level-in-swine
#7
Carlos J Leitão, Juan Rafael Lima-Rodríguez, Fatima Ferreira, Catarina Avelino, Francisco M Sánchez-Margallo, Luís Antunes
BACKGROUND: Evaluation of nociceptive-antinociceptive balance during general anesthesia is still challenging and routinely based on clinical criteria. Analgesic drug delivered may be optimized with parasympathetic tone activity (PTA) monitor. This study compares ketorolac and ketorolac/tramadol balance analgesia using a PTA monitor. METHODS: Pain intensity response was assessed using a 0-100 numerical state scale (PTA) after nociceptive stimuli in pigs under stable sevoflurane anesthesia...
June 14, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29916050/opioid-analgesic-drugs-and-serotonin-toxicity-syndrome-mechanisms-animal-models-and-links-to-clinical-effects
#8
REVIEW
Brian A Baldo
Drugs may cause serotonin toxicity by a number of different mechanisms including inhibition of serotonin uptake and metabolism, increased serotonin synthesis and release, activation of serotonin receptors, and inhibition of cytochrome P450 oxidases. Some drug interactions involving opioids can increase intrasynaptic levels of serotonin, and opioid analgesic drugs are now recognized as being involved in some cases of serotonin toxicity especially if administered in conjunction with other serotonergic medications including monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and tricyclic antidepressants...
June 18, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29914572/prescription-opioid-dispensing-in-new-south-wales-australia-spatial-and-temporal-variation
#9
M Mofizul Islam, Ian S McRae, Soumya Mazumdar, Paul Simpson, Dennis Wollersheim, Kaniz Fatema, Tony Butler
BACKGROUND: Patterns of opioid dispensing often exhibit substantial temporal and geographical variability, which has implications for public health policy decisions and interventions. The study examined recent trends in prescription opioid dispensing and identified high dispensing areas and factors associated with the doses dispensed. METHODS: Three years (1 January 2013-31 December 2015) of dispensing data of prescription opioids in local government areas (LGAs) for New South Wales (NSW), Australia's most populous state, were analyzed...
June 18, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29913392/evaluation-of-ultrasound-guided-erector-spinae-plane-block-for-postoperative-analgesia-in-laparoscopic-cholecystectomy-a-prospective-randomized-controlled-clinical-trial
#10
Serkan Tulgar, Mahmut Sertan Kapakli, Ozgur Senturk, Onur Selvi, Talat Ercan Serifsoy, Zeliha Ozer
STUDY OBJECTIVE: Laparoscopic cholecystectomy (LC) is a commonly performed minimally invasive procedure that has led to a decrease in procedure-related mortality and morbidity. However, LC requires analgesia that blocks both visceral and somatic nerve fibers. In this study, we evaluated the effectiveness of Erector Spinae Plane Block (ESPB) for postoperative analgesia management in LC. DESIGN: Single-blinded, prospective, randomized, efficiency study. SETTING: Tertiary university hospital, postoperative recovery room & ward...
June 15, 2018: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/29910546/comparision-of-analgesic-efficacy-of-tramadol-infusion-versus-tramadol-plus-ondansetron-infusion-in-medical-intensive-care-unit
#11
Surya Prakash Yarramalle, Kartik Munta, S Manimala Rao, Pradeep Marur Venkategowda, Sagar Sunka, Sai Kiran Dudam
Background: Tramadol, a preferred analgesic due to its less respiratory depression. It also has a central action that blocks the reuptake and enhances the release of serotonin at spinal antinociceptive pathways. Ondansetron, an antiemetic is a serotonin receptor antagonist. Due to the contradictory actions of the two drugs, co-administration of these drugs resulted in higher usage of tramadol. All these studies were done in the postoperative period. Aim: The aim of this study is to evaluate the analgesic efficacy of tramadol infusion versus tramadol plus ondansetron infusion in Medical Intensive Care Unit (ICU) patients...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910495/effect-of-addition-of-dexamethasone-to-ropivacaine-on-post-operative-analgesia-in-ultrasonography-guided-transversus-abdominis-plane-block-for-inguinal-hernia-repair-a-prospective-double-blind-randomised-controlled-trial
#12
Uma Datt Sharma, Prateek, Himani Tak
Background and Aims: Ultrasonography (USG)-guided transversus abdominis plane (TAP) block is an abdominal field block with high efficacy. This study was undertaken with the aim of determining the effect of the addition of dexamethasone to 0.5% ropivacaine on post-operative analgesia in USG-guided TAP block for inguinal hernia repair. Methods: A double-blind randomised control study was conducted on sixty patients posted for inguinal hernia repair with the American Society of Anesthesiologists physical Status I or II, who were allocated two groups of 30 each...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910493/a-study-to-compare-caudal-levobupivacaine-tramadol-and-a-combination-of-both-in-paediatric-inguinal-hernia-surgeries
#13
Neelam Dogra, Rajat Dadheech, Mahipal Dhaka, Anupama Gupta
Background and Aims: Caudal block is a safe and simple method of pain relief in young children with the drawback of a short duration of analgesia which can be overcome by adding various adjuvants to the injected local anaesthetic. We compared the effects of caudal levobupivacaine, tramadol and a combination of both in paediatric patients undergoing inguinal herniotomy. Methods: A total of 78 children aged 1-7 years, planned for inguinal herniotomy were randomly allocated into three groups...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29906478/does-nicotine-impact-tramadol-abuse-insights-from-neurochemical-and-neurobehavioral-changes-in-mice
#14
Shimaa M Azmy, Mai A Abd El Fattah, Sahar S Abd El-Rahman, Somia A Nada, Omar M E Abdel Salam, Mohammed F El-Yamany, Noha N Nassar
Nicotine and tramadol concomitant drug dependence pose increasing social, economic as well as public threats. Accordingly, the present study investigated neurochemical, neurobehavioral and neuropathological changes in the brain subsequent to the interaction of nicotine and tramadol. To this end, tramadol (20 mg/kg, i.p) and nicotine (0.25 mg/kg, i.p) were administrated to male albino mice once daily for 30 days. Consequent to microglial activation, nicotine exacerbated oxidative/nitrosative stress induced by tramadol as manifest by the step-up in thiobarbituric acid reactive substances and nitric oxide subsequent to the enhanced levels of neuronal and inducible nitric oxide synthases; paralleled by decreased non-protein sulfhydryls...
June 12, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29904327/pregabalin-misuse-and-abuse-in-jordan-a-qualitative-study-of-user-experiences
#15
Amneh Al-Husseini, Mayyada Wazaify, Marie Claire Van Hout
Pregabalin is currently approved for the treatment of epilepsy, generalized anxiety disorder, neuropathic pain, and fibromyalgia. A qualitative study was undertaken in Jordan, where concerns have been raised about its unprescribed availability in community pharmacies and thereby its abuse. Semi-structured interviews were conducted with all patients with a history of pregabalin use in two Jordanian addiction treatment centers. All were male patients aged 21-30 years ( n  = 11). The majority was poly-drug abusers and had a previous history of substance abuse (tramadol, Captagon, synthetic cannabinoids, and marijuana) ...
2018: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/29903752/what-place-is-there-for-tramadol-dexketoprofen
#16
(no author information available yet)
No single analgesic provides effective pain relief in all patients and increasing the dose of an analgesic may increase its unwanted effects.1 In addition, pain frequently results from multiple mechanisms that may respond to different pharmacological interventions.2 One suggested approach is to combine analgesics with different modes of action, with the aim of delivering better analgesia using lower doses of each drug.1 Skudexa (A. Menarini Farmaceutica Internazionale SRL), a combination of tramadol hydrochloride (a synthetic opioid analgesic that is a partial agonist at the μ, δ and κ opioid receptors) and dexketoprofen (a NSAID), is licensed for short term treatment of moderate to severe acute pain in adults...
June 2018: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/29881433/gender-dependency-in-streoselective-pharmacokinetics-of-tramadol-and-its-phase-i-metabolites-in-relation-to-cyp2d6-phenotype-in-iranian-population
#17
Yalda Hosseinzadeh Ardakani, Hoda Lavasani, Mohammad-Reza Rouini
The stereoselective pharmacokinetic of Tramadol (T) and its main metabolites concerning the influence of CYP2D6 phenotype and gender on the phase I metabolism of this compound was studied after administration of 100 mg single oral dose of racemic T to 24 male and female subjects. The pharmacokinetic parameters were estimated from plasma concentrations of the analytes enantiomers. The metabolic ratio of T enantiomers was used for CYP2D6 phenotype determination. The plasma concentrations of both tramadol enantiomers were considerably higher in Poor metabolizers (PM) than in extensive metabolizers (EM), resulting in 43% and 37% increase in AUC values of (+)-T and (-)-T respectively...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29880563/opioid-prescribing-for-chronic-musculoskeletal-pain-in-uk-primary-care-results-from-a-cohort-analysis-of-the-copers-trial
#18
Tomi Ashaye, Natalia Hounsome, Dawn Carnes, Stephanie J C Taylor, Kate Homer, Sandra Eldridge, Anne Spencer, Anisur Rahman, Jens Foell, Martin R Underwood
OBJECTIVE: To establish the level of opioid prescribing for patients with chronic musculoskeletal pain in a sample of patients from primary care and to estimate prescription costs. DESIGN: Secondary data analyses from a two-arm pragmatic randomised controlled trial (COPERS) testing the effectiveness of group self-management course and usual care against relaxation and usual care for patients with chronic musculoskeletal pain (ISRCTN 24426731). SETTING: 25 general practices and two community musculoskeletal services in the UK (London and Midlands)...
June 6, 2018: BMJ Open
https://www.readbyqxmd.com/read/29872601/serotonin-syndrome-presenting-with-concomitant-tramadol-and-diphenhydramine-use-a-case-report-of-an-unlikely-side-effect
#19
Salman Khan, Shakir Saud, Imran Khan, Muhammad Asif, Osama Ismail, Arqam Salam, Tsu Jung Yang, Kim J Norville
Serotonin syndrome is a condition that occurs following the administration of serotonergic drugs. Interestingly, on rare occasions, it can occur with various drug combinations that can secondarily affect the serum levels of 5-hydroxytryptamin. Tramadol is an analgesic that has mu opioid receptor agonist activity and has also been shown to inhibit the reuptake of serotonin and noradrenaline. Diphenhydramine is a first-generation histamine antagonist prescribed to treat or prevent allergic reactions and can also be used as a sleeping aid...
April 4, 2018: Curēus
https://www.readbyqxmd.com/read/29872240/new-findings-on-local-tramadol-use-in-oral-surgery
#20
REVIEW
Petar Đanić, Ivan Salarić, Darko Macan
In modern times, all procedures in oral surgery need to be painless and management of postoperative pain needs to be adequate. The surgical extraction of the third molar or alveolectomy of the wisdom tooth is one of the most common surgical procedures carried out in oral surgery and it includes rising a flap, bone removal and suturing. These surgical procedures usually cause swelling, trismus and moderate to severe pain. Third molar surgery is often used as a model in clinical trials that are directed toward reducing postoperative pain and improving its management...
December 2017: Acta Stomatologica Croatica
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