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Non-allergic asthma

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https://www.readbyqxmd.com/read/27925656/mold-and-dampness-exposure-and-allergic-outcomes-from-birth-to-adolescence-data-from-the-bamse-cohort
#1
Jesse D Thacher, Olena Gruzieva, Göran Pershagen, Erik Melén, Johnny C Lorentzen, Inger Kull, Anna Bergström
BACKGROUND: Exposure to moldy or damp indoor environments is associated with allergic disease in young children, but it is unclear if the effects persist to adolescence. Our objective was to assess if exposure to mold or dampness during infancy increases the risk of asthma, rhinitis, or IgE sensitization in children followed from birth to 16 years of age. METHODS: We collected questionnaire derived reports of mold or dampness indicators and allergic outcomes from 3798 children in a Swedish birth cohort (BAMSE)...
December 7, 2016: Allergy
https://www.readbyqxmd.com/read/27918476/antenatal-dexamethasone-exposure-in-preterm-infants-is-associated-with-allergic-diseases-and-the-mental-development-index-in-children
#2
Wan-Ning Tseng, Chih-Cheng Chen, Hong-Ren Yu, Li-Tung Huang, Ho-Chang Kuo
Background: Antenatal steroid administration may benefit fetal lung maturity in preterm infants. Although some studies have shown that this treatment may increase asthma in childhood, the correlation between antenatal dexamethasone exposure and allergic diseases remains unclear. The purpose of this study is to investigate the association between antenatal dexamethasone and T cell expression in childhood allergic diseases. Methods: We recruited a cohort of preterm infants born at Kaohsiung Chang Gung Memorial Hospital between 2007 and 2010 with a gestational age of less than 35 weeks and body weight at birth of less than 1500 g...
December 3, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27917628/association-between-ptpn22-ctla-4-gene-polymorphism-and-allergic-rhinitis-with-asthma-in-children
#3
Shang Hua Song, Xiao Qiang Wang, Yang Shen, Su Ling Hong, Xia Ke
Allergic rhinitis (AR) is an IgE-mediated upper airway disease, and its impact on asthma has been widely recognized. Protein tyrosine phosphatase non-receptor 22 (PTPN22) gene and the cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms have been reported to be associated with several immune-related diseases. Here we investigated the reffect of these two genes' polymorphisms on the risk of AR and asthma in Chinese Han children. A total of 106 AR patients, 112 AR with asthma patients, and 109 healthy children were enrolled in the study...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27916272/regulation-and-function-of-anaphylatoxins-and-their-receptors-in-allergic-asthma
#4
Yves Laumonnier, Anna V Wiese, Julia Figge, Christian Karsten
Allergic asthma is a disease of the airways driven by maladaptive T helper 2 (Th2) and Th17 immune response against harmless, airborne substances. The hallmarks of this disease are airway hyperresponsiveness (AHR), eosinophilic and neutrophilic airway inflammation and mucus overproduction. Distinct dendric cell (DC) subsets together with airway epithelial and pulmonary vascular endothelial cells play critical roles in allergen sensing and in driving T cell differentiation towards Th2 and Th17 effector or regulatory T cells (Treg)...
December 1, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27906453/syk-inhibition-blocks-airway-constriction-and-protects-from-th2-induced-airway-inflammation-and-remodeling-in-mice
#5
Christoph Tabeling, Julia Herbert, Andreas C Hocke, David Lamb, Lutz Wollin, Klaus Erb, Ekaterina Boiarina, Hesam Movassagh, Jörg Scheffel, Jan M Doehn, Stefan Hippenstiel, Marcus Maurer, Abdelilah S Gounni, Wolfgang M Kuebler, Norbert Suttorp, Martin Witzenrath
BACKGROUND: Spleen tyrosine kinase (Syk) is an intracellular non-receptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk inhibition on airway constriction independent of allergen sensitization remain elusive. METHODS: Spectral confocal microscopy of human and murine lung tissue was performed to localize Syk expression...
December 1, 2016: Allergy
https://www.readbyqxmd.com/read/27891156/usefulness-of-component-resolved-analysis-of-cat-allergy-in-routine-clinical-practice
#6
Katharina Eder, Sven Becker, Marion San Nicoló, Alexander Berghaus, Moritz Gröger
BACKGROUND: Cat allergy is of great importance, and its prevalence is increasing worldwide. Cat allergens and house dust mite allergens represent the major indoor allergens; however, they are ubiquitous. Cat sensitization and allergy are known risk factors for rhinitis, bronchial hyperreactivity and asthma. Thus, the diagnosis of sensitization to cats is important for any allergist. METHODS: 70 patients with positive skin prick tests for cats were retrospectively compared regarding their skin prick test results, as well as their specific immunoglobulin E antibody profiles with regard to their responses to the native cat extract, rFel d 1, nFel d 2 and rFel d 4...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27888720/postmortem-serum-levels-of-ige-and-mast-cell-tryptase-in-fatal-asthma
#7
Maria Pia Scarpelli, Sanjiv Keller, Lara Tran, Cristian Palmiere
The aim of this study was to characterize the concentrations of total and specific IgE as well as mast cell-derived tryptase in postmortem serum from femoral blood and evaluate the usefulness of their determination for diagnostic purposes in cases of fatal asthma attacks. 36 autopsy cases were retrospectively selected including cases of witnessed death in asthmatic subjects, deaths in asthmatics and atopic subjects with causes of death unrelated to asthma or allergic anaphylaxis as well as deaths in non-atopic, non-allergic individuals with causes of death unrelated to asthma or allergic anaphylaxis...
December 2016: Forensic Science International
https://www.readbyqxmd.com/read/27886391/estimate-of-the-total-costs-of-allergic-rhinitis-in-specialized-care-based-on-real-world-data-the-ferin-study
#8
C Colás, M Brosa, E Antón, J Montoro, A Navarro, M T Dordal, I Dávila, B Fernández-Parra, M D P Ibáñez, M Lluch-Bernal, V Matheu, C Rondón, M C Sánchez, A Valero
BACKGROUND: Despite the socioeconomic importance of allergic rhinitis (AR), very few prospective studies have been performed under conditions of routine clinical practice and with a sufficiently long observation period outside the clinical trial scenario. We prospectively estimated the direct and indirect costs of AR in patients attending specialized clinics in Spain. METHODS: Patients were recruited at random from allergy outpatient clinics in 101 health centers throughout Spain over 12 months...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27880031/increased-levels-of-plasma-soluble-human-leukocyte-antigen-g-in-persistent-wheezy-infants
#9
Fulya Tahan, Hatice Eke Gungor, Himmet Haluk Akar, Berkay Saraymen
BACKGROUND: Human leukocyte antigen (HLA)-G is a non-classical major histocompatibility complex (MHC) class I antigen characterized by limited polymorphism in its coding region, unique tissue expression pattern in physiologic conditions and immunomodulatory properties. Recently, many studies suggest that the levels of sHLA-G were higher in atopic asthma and allergic rhinitis (AR). However, this remains to be uncertain in wheezy infants. In the present study, it was aimed to determine sHLA-G levels in wheezy infants...
November 23, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27843000/changes-in-gene-expression-induced-by-histamine-fexofenadine-and-osthole-expression-of-histamine-h1-receptor-cox-2-nf-%C3%AE%C2%BAb-ccr1-chemokine-ccl5-rantes-and-interleukin-1%C3%AE-in-pbmc-allergic-and-non-allergic-patients
#10
Natalia Karolina Kordulewska, Elżbieta Kostyra, Anna Cieślińska, Michał Matysiewicz, Ewa Fiedorowicz, Edyta Sienkiewicz-Szłapka
INTRODUCTION: Fexofenadine (FXF) is a third-generation antihistamine drug and osthole is assumed as a natural antihistamine alternative. This paper compares results of histamine, FXF and osthole impact on HRH-1, COX-2, NF-κB-p50, CCR1 mRNA expression. We also measured mRNA expression of IL-1β and CCL5/RANTES in incubated peripheral blood mononuclear cells (PBMC) to compared how histamine, FXF and osthole had influence on expression level and interacts on product secretion. OBJECTIVE: The purpose was to investigate expression pattern in asthma PBMC...
November 10, 2016: Immunobiology
https://www.readbyqxmd.com/read/27829417/administration-of-jte013-abrogates-experimental-asthma-by-regulating-proinflammatory-cytokine-production-from-bronchial-epithelial-cells
#11
Tomomi Terashita, Kazuyuki Kobayashi, Tatsuya Nagano, Yoshitaka Kawa, Daisuke Tamura, Kyosuke Nakata, Masatsugu Yamamoto, Motoko Tachihara, Hiroshi Kamiryo, Yoshihiro Nishimura
BACKGROUND: Sphingosine-1-phosphate (S1P) is a bioactive phospholipid that acts as a signal transducer by binding to S1P receptors (S1PR) 1 to 5. The S1P/S1PRs pathway has been associated with remodeling and allergic inflammation in asthma, but the expression pattern of S1PR and its effects on non-immune cells have not been completely clarified. The aim of this study was to examine the contribution of the signaling of S1P and S1PRs expressed in airway epithelial cells (ECs) to asthma responses in mice...
November 9, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27828843/increase-risk-of-allergic-diseases-in-patients-with-ankylosing-spondylitis-a-10-year-follow-up-population-based-study-in-taiwan
#12
Wei-Pin Chang, Chun-Nan Kuo, Li-Na Kuo, Yao-Tung Wang, Wuu-Tsun Perng, Ho-Chang Kuo, James Cheng-Chung Wei
Th2 and Th17 cells are both associated with developing ankylosing spondylitis (AS) and asthma. Th2 cells are also associated with allergic rhinitis and atopic dermatitis (AD). The prevalence of such allergic diseases in AS patients is unknown. In this study, we intended to study the risk of allergic diseases in a 10-year follow-up population of newly diagnosed patients with AS. We used a nationwide 10-year population-based database retrieved from the Longitudinal Health Insurance Database 2005 (LHID2005) in Taiwan...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27827953/blocking-trpa1-in-respiratory-disorders-does-it-hold-a-promise
#13
REVIEW
Indranil Mukhopadhyay, Abhay Kulkarni, Neelima Khairatkar-Joshi
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles, respiratory bronchioles and upto alveolar ducts and alveoli. Functional presence of TRPA1 on non-neuronal cells got recognized recently. TRPA1 plays a well-recognized role of "chemosensor", detecting presence of exogenous irritants and endogenous pro-inflammatory mediators that are implicated in airway inflammation and sensory symptoms like chronic cough, asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis and cystic fibrosis...
November 5, 2016: Pharmaceuticals
https://www.readbyqxmd.com/read/27826964/comorbidities-and-phenotypes-of-rhinitis-in-korean-children-and-adolescents-a-cross-sectional-multicenter-study
#14
Kyung Suk Lee, Hye Yung Yum, Youn Ho Sheen, Yong Mean Park, Yong Ju Lee, Bong Seok Choi, Hye Mi Jee, Sun Hee Choi, Hyun Hee Kim, Yang Park, Hyo Bin Kim, Yeong Ho Rha
PURPOSE: Rhinitis is a nasal inflammatory disease in children and adolescents. However, little is known about the phenotypes and characteristics of allergic rhinitis (AR) in Korean children and adolescents. The objective of this study was to analyze the symptoms and comorbidities of rhinitis, to compare AR to non-allergic rhinitis (NAR), and to reveal the phenotypes and features of AR in a Korean pediatric population. METHODS: Patients under 18 years of age with rhinitis symptoms were recruited from January 2013 to January 2015 by pediatric allergists...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27823578/measuring-nasal-nitric-oxide-in-allergic-rhinitis-patients
#15
V S Nesic, V Z Djordjevic, V Tomic-Spiric, Z R Dudvarski, I A Soldatovic, N A Arsovic
OBJECTIVE: This study aimed to compare two sampling methods for nasal nitric oxide in healthy individuals and allergic rhinitis patients, and to examine the within-subject reliability of nasal nitric oxide measurement. METHODS: The study included 23 allergic rhinitis patients without concomitant asthma and 10 healthy individuals. For all participants, nitric oxide levels were measured non-invasively from the lungs through the mouth (i.e. the oral fractional exhaled nitric oxide) and the nose...
November 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27820664/compliance-with-allergen-immunotherapy-and-factors-affecting-compliance-among-patients-with-respiratory-allergies
#16
Fardous Musa, Mona Al-Ahmad, Nermina Arifhodzic, Waleed Al-Herz
BACKGROUND: Allergen-specific immunotherapy (AIT) is safe and effective for the treatment of allergic rhinitis and allergic asthma. However, patient non-compliance is a major barrier to achieving optimal outcomes. OBJECTIVE: To determine the level of compliance among patients using AIT and to identify factors associated with non-compliance. METHODS: A retrospective analysis using questionnaires was conducted to study compliance among 236 patients with allergic rhinitis with or without asthma who began AIT in 2009 or 2010...
November 7, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27801958/nasal-obstructive-disorders-induce-medical-treatment-failure-in-pediatric-persistent-allergic-rhinitis-the-nodpar-study
#17
Franklin S Mariño-Sánchez, Meritxell Valls-Mateus, Karen Ruiz-Echevarría, Isam Alobid, Paulina Cardenas-Escalante, Rosa Jiménez-Feijoo, Jaime Lozano-Blasco, María T Giner-Muñoz, Jesús Rodríguez-Jorge, Oliver Haag, Ana M Plaza-Martin, Joaquim Mullol
BACKGROUND: Allergic rhinitis (AR) is the most common chronic disease among children. To characterize the disease, a modified classification of severity (m-ARIA) has recently been validated in AR children. When medical treatment fails, surgery for nasal obstructive disorders (NOD) may be a therapeutic option. Our objective was to assess the prevalence of NOD and their influence in medical treatment response among children with persistent AR (PER). METHODS: In a prospective, real-life study, 130 pediatric PER patients (13...
November 1, 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/27790282/association-of-specific-immunoglobulin-e-to-staphylococcal-enterotoxin-with-airway-hyperresponsiveness-in-asthma-patients
#18
Seong Han Kim, Seo Yeon Yang, Jihong You, Sang Bae Lee, Jin You, Yoon Soo Chang, Hyung Jung Kim, Chul Min Ahn, Min Kwang Byun, Hye Jung Park, Jung-Won Park
BACKGROUND: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. METHODS: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects...
October 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27783037/mir-155-a-novel-target-in-allergic-asthma
#19
REVIEW
Hong Zhou, Junyao Li, Peng Gao, Qi Wang, Jie Zhang
MicroRNAs (miRNAs), a class of small non-coding RNAs of 18-24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma...
October 24, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27782330/old-dogs-new-tricks-immunoregulatory-properties-of-c3-and-c5-cleavage-fragments
#20
REVIEW
Admar Verschoor, Christian M Karsten, Steven P Broadley, Yves Laumonnier, Jörg Köhl
The activation of the complement system by canonical and non-canonical mechanisms results in the generation of multiple C3 and C5 cleavage fragments including anaphylatoxins C3a and C5a as well as opsonizing C3b/iC3b. It is now well appreciated that anaphylatoxins not only act as pro-inflammatory mediators but as immunoregulatory molecules that control the activation status of cells and tissue at several levels. Likewise, C3b/iC3b is more than the opsonizing fragment that facilitates engulfment and destruction of targets by phagocytes...
November 2016: Immunological Reviews
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