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https://www.readbyqxmd.com/read/28533689/medication-related-costs-of-rhinitis-in-australia-a-nostradata-cross-sectional-study-of-pharmacy-purchases
#1
Pete Smith, David Price, Richard Harvey, Andrew Simon Carney, Vicky Kritikos, Sinthia Z Bosnic-Anticevich, Louise Christian, Derek Skinner, Victoria Carter, Alice Marie Sybille Durieux
PURPOSE: There is a relative paucity of research regarding medication expenditure associated with multiple-therapy use for rhinitis in Australia. To describe 1) the nature and extent of multiple-therapy use for rhinitis in Australia using data on therapies purchased with prescription or over-the-counter (OTC) and 2) additional costs incurred by multiple-therapy use compared with intranasal corticosteroid (INCS) therapy alone. PATIENTS AND METHODS: A retrospective observational study was carried out using a database containing anonymous pharmacy transaction data available from 20% of pharmacies in Australia that links doctor prescriptions and OTC purchase information...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28500687/epidemiological-analysis-and-follow-up-of-human-rhinovirus-infection-in-children-with-asthma-exacerbation
#2
Shou-Yan Zheng, Li-Li Wang, Luo Ren, Jian Luo, Wei Liao, En-Mei Liu
To determine the prevalence of human rhinovirus (HRV) infection in children with acute asthma exacerbations, investigation of HRV viral load and severity of asthma exacerbations is also required. Nasopharyngeal aspirates and swabs were collected and assessed for respiratory viruses. HRV-positive samples were sequenced to identify types and determine viral load. Outpatients with asthma exacerbations underwent follow-up evaluations, their swabs were collected and clinical outcomes were recorded at their next clinic visit 4 weeks later...
May 13, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28497924/real-life-efficacy-of-omalizumab-after-9-years-of-follow-up
#3
Francesco Menzella, Carla Galeone, Debora Formisano, Claudia Castagnetti, Patrizia Ruggiero, Anna Simonazzi, Luigi Zucchi
Omalizumab is frequently used as add-on treatment to inhaled corticosteroids (ICS) and long-acting β2-agonists in patients with suboptimal control of severe asthma. Patients with severe asthma will typically require chronic treatment, although due to the limited amount of data available there are still some concerns about the safety and efficacy of long-term therapy with omalizumab. Herein, in an extension of a previous 4-year study, we report disease-related outcomes of 8 patients with severe persistent allergic asthma who have been followed for a total of 9 years in a real-life setting...
July 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28497854/allergic-sinusitis-and-severe-asthma-caused-by-occupational-exposure-to-locust-bean-gum-case-report
#4
Brie Hawley, Kristin J Cummings, Mohammed Mohammed, Anne E Dimmock, Rebecca Bascom
We present a case that highlights the difficulties with diagnosis and the dangers of occupational allergic sinusitis and asthma left unrecognized. We describe the case history of a man who experienced work-related symptoms 1 year after beginning work as a cheesemaker at a creamery, and whose respiratory symptoms progressively worsened over 16 years before an occupational cause of his asthma was identified. His initial discrete episodes of sinusitis and acute bronchitis evolved into persistent asthma of increasing severity with exacerbations requiring repeated emergency room treatment...
May 12, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28489129/growth-velocity-and-weight-gain-in-prepubertal-asthmatic-children
#5
Larissa Celiberto Renosto, Carla Acatauassu, Itana Andrade, Marina Rafael, Talita Lemos Paulino, Fabíola Isabel Suano-Souza, Dirceu Solé, Roseli Oselka Saccardo Sarni
Objective: To evaluate the stature growth rate (GR) and the weight gain of prepubertal asthmatic children. Method: A retrospective cohort study evaluating medical records of 85 children diagnosed with asthma, aged less than 9 years, of both sexes, with at least one year of follow-up in the allergy outpatient clinic. The data on the disease, weights and heights were collected through a standardized questionnaire on two occasions, with an interval of one year. The curves proposed by Tanner were applied for the analysis of the GR, and the Z-score of the GR (ZGR) was calculated...
March 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28487836/allergic-conjunctivitis-in-asia
#6
REVIEW
Bernard Yu-Hor Thong
Allergic conjunctivitis (AC), which may be acute or chronic, is associated with rhinitis in 30%-70% of affected individuals, hence the term allergic rhinoconjunctivitis (AR/C). Seasonal and perennial AC is generally milder than the more chronic and persistent atopic and vernal keratoconjunctivitis. Natural allergens like house dust mites (HDM), temperate and subtropical grass and tree pollen are important triggers that drive allergic inflammation in AC in the Asia-Pacific region. Climate change, environmental tobacco smoke, pollutants derived from fuel combustion, Asian dust storms originating from central/north Asia and phthalates may also exacerbate AR/C...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28482010/study-toward-resolving-the-controversy-over-the-definition-of-allergic-fungal-rhinosinusitis
#7
Aleksandra Barac, Goran Stevanovic, Marina Pekmezovic, Zoran Rakocevic, Rajica Stosovic, Boban Erovic, Vesna Tomic Spiric
Dysbiosis of the microbiome on the airway mucosa leads to the development of chronic inflammatory and allergic disorders. The aim of this study was to consider the potential diagnostic criteria for allergic fungal rhinosinusitis (AFRS) and nonallergic fungal rhinosinusitis (FRS), and the role of fungal presence in an environment for the development of AFRS. In this study, 136 patients were divided into two groups: patients with positive specific immunoglobulin E (sIgE) and fungal finding (AFRS group), and patients with negative sIgE and positive fungal finding (FRS group)...
May 6, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28481134/the-role-of-oxidative-stress-in-the-clinical-manifestations-of-childhood-asthma
#8
Aleksandra Topic, Djordje Francuski, Aleksandra Nikolic, Katarina Milosevic, Snezana Jovicic, Bojan Markovic, Mirjana Djukic, Dragica Radojkovic
INTRODUCTION: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. MATERIALS AND METHODS: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn- superoxide dismutase (Cu,Zn-SOD) in serum...
May 8, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28479192/predictors-of-emergency-department-use-in-children-with-persistent-asthma-in-metropolitan-atlanta-georgia
#9
Jeffery M Franklin, Jocelyn R Grunwell, Alice C Bruce, Robin C Smith, Anne M Fitzpatrick
BACKGROUND: Racial disparities are evident among children with asthma in the United States, with non-Hispanic black children at particularly high risk for poor asthma outcomes, including frequent emergency department (ED) use for asthma exacerbations. OBJECTIVE: To compare asthma features in non-Hispanic black vs white children in Atlanta, Georgia, and determine what clinical features predict future ED use for asthma. METHODS: Self-reported black and white children 6 to 17 years of age with persistent asthma treated with controller medications completed medical history questionnaires, lung function testing, aeroallergen sensitization testing, and venipuncture...
May 4, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28474652/correlation-of-total-serum-immunoglobulin-e-level-sputum-and-peripheral-eosinophil-count-in-assessing-the-clinical-severity-in-bronchial-asthma
#10
Roshan M Kumar, R Pajanivel, G Koteeswaran, Surendra K Menon, Pravin Mv Charles
CONTEXT: Asthma is a chronic inflammatory disorder of the airway with involvement of various cellular populations and release of many inflammatory mediators. Eosinophils and serum immunoglobulin E (IgE) are considered a good marker of airway inflammation in asthma. The correlation of clinical assessment with various markers of airway inflammation in asthma is not well established in the Indian population. AIMS: This study aims to study the correlation of serum IgE, sputum eosinophil count, and peripheral eosinophil count with clinical severity of Asthma...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28474411/a-trial-of-oral-corticosteroids-for-persistent-systemic-and-airway-inflammation-in-severe-asthma
#11
Keiji Oishi, Tsunahiko Hirano, Ryo Suetake, Syuichiro Ohata, Yoshikazu Yamaji, Kosuke Ito, Nobutaka Edakuni, Kazuto Matsunaga
INTRODUCTION: The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. METHODS: Twenty severe asthmatics with persistent FeNO elevation (≥40 ppb) and blood eosinophilia (≥3%) despite maintenance therapy including high-daily-dose inhaled corticosteroids were analyzed...
May 4, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28464895/predictive-factors-for-moderate-or-severe-exacerbations-in-asthma-patients-receiving-outpatient-care
#12
Francisco Javier Álvarez Gutiérrez, Marta Ferrer Galván, Juan Francisco Medina Gallardo, Marta Barrera Mancera, Beatriz Romero Romero, Auxiliadora Romero Falcón
BACKGROUND: Asthma exacerbations are important events that affect disease control, but predictive factors for severe or moderate exacerbations are not known. The objective was to study the predictive factors for moderate (ME) and severe (SE) exacerbations in asthma patients receiving outpatient care. METHODS: Patients aged > 12 years with asthma were included in the study and followed-up at 4-monthly intervals over a 12-month period. Clinical (severity, level of control, asthma control test [ACT]), atopic, functional, inflammatory, SE and ME parameters were recorded...
May 2, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28461761/managing-the-pediatric-patient-with-refractory-asthma-a-multidisciplinary-approach
#13
REVIEW
James Cook, Fran Beresford, Valentina Fainardi, Pippa Hall, Georgie Housley, Angela Jamalzadeh, Michelle Nightingale, David Winch, Andrew Bush, Louise Fleming, Sejal Saglani
Children with asthma that is refractory to high levels of prescribed treatment are described as having problematic severe asthma. Those in whom persistent symptoms result from a failure of basic asthma management are described as having "difficult asthma", while those who remain symptomatic despite these factors having been addressed are described as having "severe therapy-resistant asthma" (STRA). The majority of children have difficult asthma; asthma that is poorly controlled because of a failure to get the basics of asthma management right...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28461300/addressing-unmet-needs-in-understanding-asthma-mechanisms-from-the-european-asthma-research-and-innovation-partnership-earip-work-package-wp-2-collaborators
#14
REVIEW
Michael R Edwards, Sejal Saglani, Jurgen Schwarze, Chrysanthi Skevaki, Jaclyn A Smith, Ben Ainsworth, Mark Almond, Evangelos Andreakos, Maria G Belvisi, Kian Fan Chung, William Cookson, Paul Cullinan, Catherine Hawrylowicz, Marek Lommatzsch, David Jackson, Rene Lutter, Benjamin Marsland, Miriam Moffatt, Mike Thomas, J Christian Virchow, Georgina Xanthou, Jessica Edwards, Samantha Walker, Sebastian L Johnston
Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28458590/does-co-payment-for-inhaler-devices-affect-therapy-adherence-and-disease-outcomes-a-historical-matched-cohort-study
#15
Jaco Voorham, Bernard Vrijens, Job Fm van Boven, Dermot Ryan, Marc Miravitlles, Lisa M Law, David B Price
BACKGROUND: Adherence to asthma and chronic obstructive pulmonary disease (COPD) treatment has been shown to depend on patient-level factors, such as disease severity, and medication-level factors, such as complexity. However, little is known about the impact of prescription charges - a factor at the health care system level. This study used real-life data to investigate whether co-payment affects adherence (implementation and persistence) and disease outcomes in patients with asthma or COPD...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28449653/a-case-report-of-parapneumonic-pleural-effusion-caused-by-streptococcus-pneumoniae-serotype-19a-in-a-child-immunized-with-13-valent-conjugate-pneumococcal-vaccine
#16
Idrissa Diawara, Khalid Zerouali, Naima Elmdaghri, Abderrahman Abid
BACKGROUND: Simple parapneumonic effusion is a pleural effusion associated with lung infection (i.e., pneumonia). Streptococcus pneumoniae remains the most common pathogen causing parapneumonic effusions. In Morocco, the pneumococcal conjugate vaccine 13-valent (PCV13) was introduced in the national immunization program in October 2010 in 2 + 1 schedule for prevention of pneumococcal disease, and replaced by the PCV10 in July 2012 in the same schedule. We report a case of parapneumonic pleural effusions caused by S...
April 27, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28438546/clinical-predictors-of-remission-and-persistence-of-adult-onset-asthma
#17
Guus A Westerhof, Hanneke Coumou, Selma B de Nijs, ElsJ Weersink, Elizabeth H Bel
BACKGROUND: Adult-onset asthma is an important but relatively understudied asthma phenotype and little is known about its natural course and prognosis. The remission rate is believed to be low, and it is still obscure which factors predict remission or persistence of the disease. OBJECTIVE: To determine the remission rate, and identify predictors of persistence and remission of adult-onset asthma. METHODS: Two hundred adult patients with recently diagnosed (<1 year) asthma were recruited from secondary and tertiary pulmonary clinics and prospectively followed for 5 years...
April 21, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28421345/long-term-predictors-of-anxiety-and-depression-in-adult-patients-with-asthma
#18
Marina Labor, Slavica Labor, Iva Jurić, Vladimir Fijačko, Sanja Popović Grle, Davor Plavec
BACKGROUND: It is well established that anxiety and depression are associated with asthma, but there is limited evidence about the persistence of anxiety/depression in asthma. The aim of our study was to assess the long-term predictors of anxiety and depression in adult asthmatic patients. METHODS: A total of 90 adult asthma patients (63 women, age 18-50 years) with different levels of disease control (28 uncontrolled and 34 partially controlled) were assessed at baseline and at follow-up after 7 years for anxiety, depression and asthma control...
April 18, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28417624/cow-s-milk-desensitization-in-anaphylactic-patients-a-new-personalized-dose-method
#19
Delara Babaie, Mohammad Nabavi, Saba Arshi, Mehrnaz Mesdaghi, Zahra Chavoshzadeh, Mohammad Hasan Bemanian, Mitra Tafakori, Mehrdad Amirmoini, Hosein Esmailzadeh, Rasoul Molatefi, Mahsa Rekabi, Nadieh Akbarpour, Farimah Masoumi, Morteza Fallahpour
Cow's milk allergy (CMA) is the most frequent food allergy in children and oral immunotherapy (OIT) is a promising approach for treatment of patients. The most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. Considering that CMA varies among patients, an individualized OIT protocol would be beneficial to achieve a safer and more efficient method of desensitization. 18 children more than 3 years of age with IgE-mediated CMA were enrolled...
February 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28392707/factors-predicting-persistence-of-early-wheezing-through-childhood-and-adolescence-a-systematic-review-of-the-literature
#20
Carlos E Rodríguez-Martínez, Monica P Sossa-Briceño, Jose A Castro-Rodriguez
BACKGROUND: For the early identification of persistent asthma symptoms among young children with recurrent wheezing, it would be helpful to identify all available studies that have identified at least one factor for predicting the persistence of early wheezing. The objective of the present study was to perform a systematic review of all studies that have identified factors that predict the persistence of symptoms among young patients with recurring wheezing. METHODS: A systematic review of relevant studies was conducted through searching in MEDLINE, EMBASE, CINHAL, and SCOPUS databases up to June 2016...
2017: Journal of Asthma and Allergy
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