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https://www.readbyqxmd.com/read/29333638/rapid-profiling-of-polymeric-phenolic-acids-in-salvia-miltiorrhiza-by-hybrid-data-dependent-targeted-multistage-mass-spectrometry-acquisition-based-on-expected-compounds-prediction-and-fragment-ion-searching
#1
Yao Shen, Zijin Feng, Min Yang, Zhe Zhou, Sumei Han, Jinjun Hou, Zhenwei Li, Wanying Wu, De-An Guo
Phenolic acids are the major water-soluble components in Salvia miltiorrhiza (> 5%). According to previous studies, many of them contribute to the cardiovascular effects and antioxidant effects of S. miltiorrhiza. Polymeric phenolic acids can be considered as the tanshinol derived metabolites, e.g., dimmers, trimers and tetramers. A strategy combined with tanshinol-based expected compounds prediction, total ion chromatogram filtering, Fragment Ion Searching and parent list-based multistage mass spectrometry acquisition by Linear Trap Quadropole-orbitrap Velos Mass Spectrometry was proposed to rapid profile polymeric phenolic acids in S...
January 15, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29331276/analyzing-recommender-systems-for-health-promotion-using-a-multidisciplinary-taxonomy-a-scoping-review
#2
Santiago Hors-Fraile, Octavio Rivera-Romero, Francine Schneider, Luis Fernandez-Luque, Francisco Luna-Perejon, Anton Civit-Balcells, Hein de Vries
BACKGROUND: Recommender systems are information retrieval systems that provide users with relevant items (e.g., through messages). Despite their extensive use in the e-commerce and leisure domains, their application in healthcare is still in its infancy. These systems may be used to create tailored health interventions, thus reducing the cost of healthcare and fostering a healthier lifestyle in the population. OBJECTIVE: This paper identifies, categorizes, and analyzes the existing knowledge in terms of the literature published over the past 10 years on the use of health recommender systems for patient interventions...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29329979/how-acute-stress-may-enhance-subsequent-memory-for-threat-stimuli-outside-the-focus-of-attention-dlpfc-amygdala-decoupling
#3
Yu Luo, Guillén Fernández, Erno Hermans, Susanne Vogel, Yu Zhang, Hong Li, Floris Klumpers
Stress-related disorders, e.g., anxiety and depression, are characterized by decreased top-down control for distracting information, as well as a memory bias for threatening information. However, it is unclear how acute stress biases mnemonic encoding and leads to prioritized storage of threat-related information even if outside the focus of attention. In the current study, healthy adults (N = 53, all male) were randomly assigned to stress induction using the socially evaluated cold-pressor test (SECPT) or a control condition...
January 9, 2018: NeuroImage
https://www.readbyqxmd.com/read/29328995/filter-base-a-web-accessible-chemical-database-for-small-compound-libraries
#4
Baban S Kolte, Sanjay R Londhe, Bhushan R Solanki, Rajesh N Gacche, Rohan J Meshram
Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup...
January 6, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29327814/systematic-evaluation-of-protein-sequence-filtering-algorithms-for-proteoform-identification-using-top-down-mass-spectrometry
#5
Qiang Kou, Si Wu, Xiaowen Liu
Complex proteoforms contain various primary structural alterations resulting from variations in genes, RNA, and proteins. Top-down mass spectrometry is commonly used for analyzing complex proteoforms because it provides whole sequence information of the proteoforms. Proteoform identification by top-down mass spectral database search is a challenging computational problem because the types and/or locations of some alterations in target proteoforms are in general unknown. Although spectral alignment and mass graph alignment algorithms have been proposed for identifying proteoforms with unknown alterations, they are extremely slow to align millions of spectra against tens of thousand protein sequences in high throughput proteome level analyses...
January 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29318991/in-vitro-investigation-of-the-pediculicidal-activities-of-the-volatile-oil-components-of-some-medical-plants-raised-in-turkey
#6
M Emin Limoncu, Cüneyt Balcıoğlu, Tuğba Oyur, Gizem Zeybek, Ulvi Zeybek
OBJECTIVE: The human head louse Pediculus capitis has recently acquired resistance to commercially available insecticides, which has expanded the search concerning the pediculicidal activities of some herbal products. The present study aimed to assess the in vitro pediculicidal activities of volatile oils extracted from 10 medical plants raised in Turkey: Rosa damascena (red provins rose), Pelargonium graveolens (geranium), Lavandula angustifolia (lavender), Salvia triloba (salvia), Rosmarinus officinalis (rosemary; two different chemotypes), Citrus bergamia (citrus tree), Cymbopogon nardus (citronella), Citrus limonum (lemon), and Cymbopogon flexuosus (lemongrass)...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29316968/improving-the-interoperability-of-biomedical-ontologies-with-compound-alignments
#7
Daniela Oliveira, Catia Pesquita
BACKGROUND: Ontologies are commonly used to annotate and help process life sciences data. Although their original goal is to facilitate integration and interoperability among heterogeneous data sources, when these sources are annotated with distinct ontologies, bridging this gap can be challenging. In the last decade, ontology matching systems have been evolving and are now capable of producing high-quality mappings for life sciences ontologies, usually limited to the equivalence between two ontologies...
January 9, 2018: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/29316548/determinants-of-dental-care-attendance-during-pregnancy-a-systematic-review
#8
Juliana Schaia Rocha, Letícia Yumi Arima, Renata Iani Werneck, Samuel Jorge Moysés, Márcia Helena Baldani
Despite the fact that dental care attendance during pregnancy has been recommended by guidelines and institutions, the demand for dental services is still low among pregnant women. The aim of this study was to identify and analyze the determinants of dental care attendance during pregnancy. We performed a systematic literature search in the electronic databases PubMed, Scopus, Web of Science, Latin American and Caribbean Health Sciences Literature, Brazilian Library in Dentistry, Cumulative Index to Nursing and Allied Health Literature, and Medline using relevant keywords...
January 10, 2018: Caries Research
https://www.readbyqxmd.com/read/29316306/information-retrieval-for-systematic-reviews-in-food-and-feed-topics-a-narrative-review
#9
Hannah Wood, Annette O'Connor, Jan Sargeant, Julie Glanville
INTRODUCTION: Systematic review methods are now being used for reviews of food production, food safety and security, plant health, and animal health and welfare. Information retrieval methods in this context have been informed by human healthcare approaches and ideally should be based on relevant research and experience. OBJECTIVE: This narrative review seeks to identify and summarise current research-based evidence and experience on information retrieval for systematic reviews in food and feed topics...
January 9, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29314757/machine-learning-for-identifying-randomized-controlled-trials-an-evaluation-and-practitioner-s-guide
#10
Iain Marshall, Anna Noel Storr, Joël Kuiper, James Thomas, Byron C Wallace
Machine learning (ML) algorithms have proven highly accurate for identifying Randomized Controlled Trials (RCTs), but are not used much in practice, in part because the best way to make use of the technology in a typical workflow is unclear. In this work we evaluate ML models for RCT classification (Support Vector Machines [SVMs], Convolutional Neural Networks [CNNs], and ensemble approaches). We trained and optimised SVM and CNN models on the titles and abstracts of the Cochrane Crowd RCT set. We evaluated the models on an external dataset (Clinical Hedges), allowing direct comparison with traditional database search filters...
January 4, 2018: Research Synthesis Methods
https://www.readbyqxmd.com/read/29313209/an-ensemble-framework-coping-with-instability-in-the-gene-selection-process
#11
José A Castellanos-Garzón, Juan Ramos, Daniel López-Sánchez, Juan F de Paz, Juan M Corchado
This paper proposes an ensemble framework for gene selection, which is aimed at addressing instability problems presented in the gene filtering task. The complex process of gene selection from gene expression data faces different instability problems from the informative gene subsets found by different filter methods. This makes the identification of significant genes by the experts difficult. The instability of results can come from filter methods, gene classifier methods, different datasets of the same disease and multiple valid groups of biomarkers...
January 8, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29312854/antibiotic-bone-cement-s-effect-on-infection-rates-in-primary-and-revision-total-knee-arthroplasties
#12
Donald Kleppel, Jacob Stirton, Jiayong Liu, Nabil A Ebraheim
AIM: To compare infection rates in primary and revision total knee arthroplasty (TKA) procedures using antibiotic impregnated bone cement (AIBC) to those rates in procedures not using AIBC. METHODS: A systematic review and meta-analysis was conducted in search for randomized controlled trials/studies (RCTs) pertaining to the field of antibiotic AIBC vs non-AIBC groups in both primary and revision TKA procedures. The primary literature search performed was to identify all RCTs that assessed AIBC in primary and revision TKA procedures...
December 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29304432/the-largest-lyapunov-exponent-of-gait-in-young-and-elderly-individuals-a-systematic-review
#13
REVIEW
Sina Mehdizadeh
The largest Lyapunov exponent (LyE) is an accepted method to quantify gait stability in young and old adults. However, a range of LyE values has been reported in the literature for healthy young and elderly adults in normal walking. Therefore, it has been impractical to use the LyE as a clinical measure of gait stability. The aims of this systematic review were to summarize different methodological approaches of quantifying LyE, as well as to classify LyE values of different body segments and joints in young and elderly individuals during normal walking...
December 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29304002/a-new-approach-to-design-autonomous-wireless-sensor-node-based-on-rf-energy-harvesting-system
#14
Alex Mouapi, Nadir Hakem
Energy Harvesting techniques are increasingly seen as the solution for freeing the wireless sensor nodes from their battery dependency. However, it remains evident that network performance features, such as network size, packet length, and duty cycle, are influenced by the sum of recovered energy. This paper proposes a new approach to defining the specifications of a stand-alone wireless node based on a Radio-frequency Energy Harvesting System (REHS). To achieve adequate performance regarding the range of the Wireless Sensor Network (WSN), techniques for minimizing the energy consumed by the sensor node are combined with methods for optimizing the performance of the REHS...
January 5, 2018: Sensors
https://www.readbyqxmd.com/read/29284543/external-validation-of-type-2-diabetes-computer-simulation-models-definitions-approaches-implications-and-room-for-improvement-a-protocol-for-a-systematic-review
#15
Katherine Ogurtsova, Thomas L Heise, Ute Linnenkamp, Charalabos-Markos Dintsios, Stefan K Lhachimi, Andrea Icks
BACKGROUND: Type 2 diabetes mellitus (T2DM), a highly prevalent chronic disease, puts a large burden on individual health and health care systems. Computer simulation models, used to evaluate the clinical and economic effectiveness of various interventions to handle T2DM, have become a well-established tool in diabetes research. Despite the broad consensus about the general importance of validation, especially external validation, as a crucial instrument of assessing and controlling for the quality of these models, there are no systematic reviews comparing such validation of diabetes models...
December 29, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29284417/abstract-analysis-method-facilitates-filtering-low-methodological-quality-and-high-bias-risk-systematic-reviews-on-psoriasis-interventions
#16
Francisco Gómez-García, Juan Ruano, Macarena Aguilar-Luque, Patricia Alcalde-Mellado, Jesús Gay-Mimbrera, José Luis Hernández-Romero, Juan Luis Sanz-Cabanillas, Beatriz Maestre-López, Marcelino González-Padilla, Pedro J Carmona-Fernández, Antonio Vélez García-Nieto, Beatriz Isla-Tejera
BACKGROUND: Article summaries' information and structure may influence researchers/clinicians' decisions to conduct deeper full-text analyses. Specifically, abstracts of systematic reviews (SRs) and meta-analyses (MA) should provide structured summaries for quick assessment. This study explored a method for determining the methodological quality and bias risk of full-text reviews using abstract information alone. METHODS: Systematic literature searches for SRs and/or MA about psoriasis were undertaken on MEDLINE, EMBASE, and Cochrane database...
December 29, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29283007/how-to-write-a-systematic-review-of-the-literature
#17
Debajyoti Pati, Lesa N Lorusso
This article provides a step-by-step approach to conducting and reporting systematic literature reviews (SLRs) in the domain of healthcare design and discusses some of the key quality issues associated with SLRs. SLR, as the name implies, is a systematic way of collecting, critically evaluating, integrating, and presenting findings from across multiple research studies on a research question or topic of interest. SLR provides a way to assess the quality level and magnitude of existing evidence on a question or topic of interest...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29275145/taxane-based-combination-therapies-for-metastatic-prostate-cancer
#18
REVIEW
Paul G Corn, Neeraj Agarwal, John Charles Araujo, Guru Sonpavde
CONTEXT: Multiple single-agent therapies improving survival are approved for the treatment of metastatic castration-resistant prostate cancer (mCRPC), including two chemotherapies, two androgen-signaling axis-targeting agents, an immunotherapeutic vaccine, and a radiopharmaceutical. Combination therapy can target multiple oncogenic pathways simultaneously, while potentially curbing the development of treatment resistance. OBJECTIVE: To provide a succinct overview of taxane-based combination therapies currently being evaluated for the treatment of metastatic prostate cancer...
December 20, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29274907/rna-seq-transcriptomic-analysis-of-the-morus-alba-l-leaves-exposed-to-high-level-uvb-with-or-without-dark-treatment
#19
Qijie Guan, Jiaojiao Yu, Wei Zhu, Bingxian Yang, Yaohan Li, Lin Zhang, Jingkui Tian
Ultraviolet-B (UVB) irradiation induces oxidative stress in plant cells due to the generation of excessive reactive oxygen species. Morus alba L. (M. abla) is an important medicinal plant used for the treatment of human diseases. Also, its leaves are widely used as food for silkworms. In our previous research, we found that a high level of UVB irradiation with dark incubation led to the accumulation of secondary metabolites in M. abla leaf. The aim of the present study was to describe and compare M. alba leaf transcriptomics with different treatments (control, UVB, UVB+dark)...
December 21, 2017: Gene
https://www.readbyqxmd.com/read/29274494/an-integrative-review-developing-and-measuring-creativity-in-nursing
#20
REVIEW
Xing Ma, Yuanyuan Yang, Xue Wang, Yuli Zang
OBJECTIVE: To analyze and synthesise the existing evidence on creativity in nursing. DESIGN: An integrative review. DATA SOURCES: A systematic search was conducted using seven English databases (PubMed, Science Direct, Web of Science, Cochrane, EBSCO, Wiley, and Medline) and the top three best Chinese databases (CNKI, Wanfang Data, and VIP). REVIEW METHODS: The combined keywords, creativity and nursing/nurse, were used to search for relevant journal articles that were written in English or Chinese from January 1995 to December 2016...
December 13, 2017: Nurse Education Today
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