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https://www.readbyqxmd.com/read/29786830/blue-light-filtering-intraocular-lenses-iols-for-protecting-macular-health
#1
REVIEW
Laura E Downie, Ljoudmila Busija, Peter R Keller
BACKGROUND: An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called blue-blocking or blue-light filtering IOLs, also reduce short-wavelength visible light transmission. The rationale for blue-light filtering IOLs derives primarily from cell culture and animal studies, which suggest that short-wavelength visible light can induce retinal photoxicity...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29781353/clinical-trials-with-multiple-endpoints-can-establish-a-correlation-but-not-yet-causality-between-dietary-supplementation-with-omega-3-fatty-acids-and-keratoconjunctivitis-sicca
#2
Roger Lee Mendoza
AIM: We review clinical evidence of therapeutic efficacy and effectiveness of omega-3 fatty acids (omega-3s) in keratoconjunctivitis sicca, colloquially known as dry eye disease. In doing so, we identify relevant literature to address the following questions: 1) What definitive guidance can clinical evidence offer eye physicians and their patients? 2) What aspects of omega-3 supplementation lack definitive evidence, and how might economic assessments help? METHODS: A targeted and systematic search strategy based on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) was designed in this study for refereed clinical trials of omega-3s in dry eye treatment...
May 21, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29780188/science-map-metaphors-a-comparison-of-network-versus-hexmap-based-visualizations
#3
Katy Börner, Adam H Simpson, Andreas Bueckle, Robert L Goldstone
Most maps of science use a network layout; few use a landscape metaphor. Human users are trained in reading geospatial maps, yet most have a hard time reading even simple networks. Prior work using general networks has shown that map-based visualizations increase recall accuracy of data. This paper reports the result of a comparison of two comparable renderings of the UCSD map of science that are: the original network layout and a novel hexmap that uses a landscape metaphor to layout the 554 subdisciplines grouped into 13 color-coded disciplines of science...
February 2018: Scientometrics
https://www.readbyqxmd.com/read/29772731/energy-efficient-gnss-signal-acquisition-using-singular-value-decomposition-svd
#4
Juan Carlos Bermúdez Ordoñez, Rosa María Arnaldo Valdés, Fernando Gómez Comendador
A significant challenge in global navigation satellite system (GNSS) signal processing is a requirement for a very high sampling rate. The recently-emerging compressed sensing (CS) theory makes processing GNSS signals at a low sampling rate possible if the signal has a sparse representation in a certain space. Based on CS and SVD theories, an algorithm for sampling GNSS signals at a rate much lower than the Nyquist rate and reconstructing the compressed signal is proposed in this research, which is validated after the output from that process still performs signal detection using the standard fast Fourier transform (FFT) parallel frequency space search acquisition...
May 16, 2018: Sensors
https://www.readbyqxmd.com/read/29770277/a-strategy-to-find-novel-candidate-anti-alzheimer-s-disease-drugs-by-constructing-interaction-networks-between-drug-targets-and-natural-compounds-in-medical-plants
#5
Bi-Wen Chen, Wen-Xing Li, Guang-Hui Wang, Gong-Hua Li, Jia-Qian Liu, Jun-Juan Zheng, Qian Wang, Hui-Juan Li, Shao-Xing Dai, Jing-Fei Huang
Background: Alzheimer' disease (AD) is an ultimately fatal degenerative brain disorder that has an increasingly large burden on health and social care systems. There are only five drugs for AD on the market, and no new effective medicines have been discovered for many years. Chinese medicinal plants have been used to treat diseases for thousands of years, and screening herbal remedies is a way to develop new drugs. Methods: We used molecular docking to screen 30,438 compounds from Traditional Chinese Medicine (TCM) against a comprehensive list of AD target proteins...
2018: PeerJ
https://www.readbyqxmd.com/read/29770176/the-top-50-most-cited-articles-on-total-ankle-arthroplasty-a-bibliometric-analysis
#6
Azeem Tariq Malik, Shahryar Noordin
Total Ankle Arthroplasty (TAA) is a relatively new and evolving field in Foot and Ankle surgery. We conducted a citation analysis to identify the characteristics of the top 50 most cited articles on total ankle arthroplasty. Using the Web of Science database and the search strategy total ankle arthroplasty OR total ankle replacement , we identified 2445 articles. After filtering for relevant articles, the top 50 cited articles on total ankle arthroplasty were retrieved for descriptive and statistical analysis...
March 29, 2018: Orthopedic Reviews
https://www.readbyqxmd.com/read/29769129/a-powerful-nonparametric-method-for-detecting-differentially-co-expressed-genes-distance-correlation-screening-and-edge-count-test
#7
Qingyang Zhang
BACKGROUND: Differential co-expression analysis, as a complement of differential expression analysis, offers significant insights into the changes in molecular mechanism of different phenotypes. A prevailing approach to detecting differentially co-expressed genes is to compare Pearson's correlation coefficients in two phenotypes. However, due to the limitations of Pearson's correlation measure, this approach lacks the power to detect nonlinear changes in gene co-expression which is common in gene regulatory networks...
May 16, 2018: BMC Systems Biology
https://www.readbyqxmd.com/read/29768105/identification-of-a-recurrent-lmo7-braf-fusion-in-papillary-thyroid-carcinoma
#8
Huiling He, Wei Li, Pearlly Yan, Ralf Bundschuh, Jackson A Killian, Jadwiga Labanowska, Pamela Brock, Rulong Shen, Nyla A Heerema, Albert de la Chapelle
BACKGROUND: The BRAFV600E mutation is the most common driver in papillary thyroid carcinoma (PTC) tumors. In recent years, gene fusions have also been recognized as important drivers of cancer in PTC. Previous studies have suggested that thyroid tumors with fusion genes frequently display an aggressive course. These observations prompted further exploration of gene fusions in PTC tumors. The aim was to search for previously unrecognized gene fusions using thyroid tissue samples from PTC patients...
May 16, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29766937/enhanced-resection-of-primary-high-grade-gliomas-using-a-combination-of-intraoperative-magnetic-resonance-imaging-and-intraoperative-fluorescence-5-aminolevulinic-acid-a-single-centre-experience
#9
Vikas Sharma, Rishabh Kedia, Karanjit S Narang, Ajaya N Jha
Background: The extent of resection (EOR) of a tumor is a proven prognostic factor in patients undergoing surgery for suspected high grade glioma. A few recent publications have shown the importance of intraoperative magnetic resonance imaging (iMRI) with 5-aminolevulinic acid (5-ALA) fluorescence-guidance in order to maximally increase the EOR. Aim: The objective of our study was to calculate the effect on survival of patients with high grade gliomas of resection using both iMRI and 5-ALA fluorescence-guidance as intraoperative adjuncts...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764783/an-analysis-of-the-parameters-used-in-speech-abr-assessment-protocols
#10
Milaine D Sanfins, Stavros Hatzopoulos, Caroline Donadon, Thais A Diniz, Leticia R Borges, Piotr H Skarzynski, Maria Francisca Colella-Santos
The aim of this study was to assess the parameters of choice, such as duration, intensity, rate, polarity, number of sweeps, window length, stimulated ear, fundamental frequency, first formant, and second formant, from previously published speech ABR studies. To identify candidate articles, five databases were assessed using the following keyword descriptors: speech ABR, ABR-speech, speech auditory brainstem response, auditory evoked potential to speech, speech-evoked brainstem response, and complex sounds...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29759531/biphasic-anaphylaxis-a-review-of-the-literature-and-implications-for-emergency-management
#11
REVIEW
Ali Pourmand, Chelsea Robinson, Wahab Syed, Maryann Mazer-Amirshahi
BACKGROUND: The biphasic reaction is a feared complication of anaphylaxis management in the emergency department (ED). The traditional recommended ED observation time is 4-6 h after complete resolution of symptoms for every anaphylaxis patient. However, there has been great controversy regarding whether this standard of care is evidence-based. METHODS: Articles were selected using a PubMed, MEDLINE search for the keywords "biphasic anaphylaxis", yielding 155 articles...
May 9, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29756125/distributed-query-aware-quantization-for-high-dimensional-similarity-searches
#12
Gheorghi Guzun, Guadalupe Canahuate
The concept of similarity is used as the basis for many data exploration and data mining tasks. Nearest Neighbor (NN) queries identify the most similar items, or in terms of distance the closest points to a query point. Similarity is traditionally characterized using a distance function between multi-dimensional feature vectors. However, when the data is high-dimensional, traditional distance functions fail to significantly distinguish between the closest and furthest points, as few dissimilar dimensions dominate the distance function...
March 2018: Advances in Database Technology: Proceedings
https://www.readbyqxmd.com/read/29753897/comparison-of-multilevel-cervical-disc-replacement-and-multilevel-anterior-discectomy-and-fusion-a-systematic-review-of-biomechanical-and-clinical-evidence
#13
REVIEW
Yang Li, Hangkai Shen, Kamran Z Khan, Shushu Fang, Zhenhua Liao, Weiqiang Liu
The present study aimed to comprehensively compare the clinical and biomechanical efficiency of combined anterior cervical discectomy and fusion (ACDF) with the anterior cervical disc replacement (ACDR) for treatment of multilevel cervical disc diease (CDD) using a meta-analysis and systematical review. A literature search was performed using Pubmed, MEDLINE, EMBASE and the Cochrane Library for papers published between January 1960 and December 2017. Both clinical and biomechanical parameters were analyzed...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751501/automated-inspection-of-defects-in-optical-fiber-connector-end-face-using-novel-morphology-approaches
#14
Shuang Mei, Yudan Wang, Guojun Wen, Yang Hu
Increasing deployment of optical fiber networks and the need for reliable high bandwidth make the task of inspecting optical fiber connector end faces a crucial process that must not be neglected. Traditional end face inspections are usually performed by manual visual methods, which are low in efficiency and poor in precision for long-term industrial applications. More seriously, the inspection results cannot be quantified for subsequent analysis. Aiming at the characteristics of typical defects in the inspection process for optical fiber end faces, we propose a novel method, “difference of min-max ranking filtering” (DO2MR), for detection of region-based defects, e...
May 3, 2018: Sensors
https://www.readbyqxmd.com/read/29750798/guidelines-for-safe-handling-of-hazardous-drugs-a-systematic-review
#15
Mari A Bernabeu-Martínez, Mateo Ramos Merino, Juan M Santos Gago, Luis M Álvarez Sabucedo, Carmina Wanden-Berghe, Javier Sanz-Valero
OBJECTIVE: To review the scientific literature related to the safe handling of hazardous drugs (HDs). METHOD: Critical analysis of works retrieved from MEDLINE, the Cochrane Library, Scopus, CINHAL, Web of Science and LILACS using the terms "Hazardous Substances", "Antineoplastic Agents" and "Cytostatic Agents", applying "Humans" and "Guidelines" as filters. Date of search: January 2017. RESULTS: In total, 1100 references were retrieved, and from those, 61 documents were selected based on the inclusion and exclusion criteria: 24 (39...
2018: PloS One
https://www.readbyqxmd.com/read/29746100/combining-ion-mobility-and-cryogenic-spectroscopy-for-structural-and-analytical-studies-of-biomolecular-ions
#16
Michael Z Kamrath, Thomas R Rizzo
Ion mobility spectrometry (IMS) has become a valuable tool in biophysical and bioanalytical chemistry because of its ability to separate and characterize the structure of gas-phase biomolecular ions on the basis of their collisional cross section (CCS). Its importance has grown with the realization that in many cases, biomolecular ions retain important structural characteristics when produced in the gas phase by electrospray ionization (ESI). While a CCS can help distinguish between structures of radically different types, one cannot expect a single number to differentiate similar conformations of a complex molecule...
May 10, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29745866/astral-iii-polynomial-time-species-tree-reconstruction-from-partially-resolved-gene-trees
#17
Chao Zhang, Maryam Rabiee, Erfan Sayyari, Siavash Mirarab
BACKGROUND: Evolutionary histories can be discordant across the genome, and such discordances need to be considered in reconstructing the species phylogeny. ASTRAL is one of the leading methods for inferring species trees from gene trees while accounting for gene tree discordance. ASTRAL uses dynamic programming to search for the tree that shares the maximum number of quartet topologies with input gene trees, restricting itself to a predefined set of bipartitions. RESULTS: We introduce ASTRAL-III, which substantially improves the running time of ASTRAL-II and guarantees polynomial running time as a function of both the number of species (n) and the number of genes (k)...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29745472/advanced-practice-radiation-therapists-an-australian-context
#18
REVIEW
Bronwyn Hilder, Pieter VanDam, Kathleen Doherty
The purpose of this scoping review is to examine the literature regarding the development, implementation, scope and extent of Advanced Practice Radiation Therapist (APRT) roles in Australia in peer reviewed journals, government reports, conference proceedings and reports. A search was undertaken of PubMed, Web of Science and CINAHL, the ASMIRT website and, and Google Scholar to identify relevant documents. Combinations of keywords with Boolean operators ((advanced practice) OR (advanced practitioner) OR (specialist)) AND ((radiation therapist) OR (radiation therapy)) were used...
May 10, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29742157/an-optimal-set-of-features-for-predicting-type-iv-secretion-system-effector-proteins-for-a-subset-of-species-based-on-a-multi-level-feature-selection-approach
#19
Zhila Esna Ashari, Nairanjana Dasgupta, Kelly A Brayton, Shira L Broschat
Type IV secretion systems (T4SS) are multi-protein complexes in a number of bacterial pathogens that can translocate proteins and DNA to the host. Most T4SSs function in conjugation and translocate DNA; however, approximately 13% function to secrete proteins, delivering effector proteins into the cytosol of eukaryotic host cells. Upon entry, these effectors manipulate the host cell's machinery for their own benefit, which can result in serious illness or death of the host. For this reason recognition of T4SS effectors has become an important subject...
2018: PloS One
https://www.readbyqxmd.com/read/29730764/status-report-on-the-high-throughput-characterization-of-complex-intact-o-glycopeptide-mixtures
#20
Adam Pap, Eva Klement, Eva Hunyadi-Gulyas, Zsuzsanna Darula, Katalin F Medzihradszky
A very complex mixture of intact, human N- and O-glycopeptides, enriched from the tryptic digest of urinary proteins of three healthy donors using a two-step lectin affinity enrichment, was analyzed by LC-MS/MS, leading to approximately 45,000 glycopeptide EThcD spectra. Two search engines, Byonic and Protein Prospector, were used for the interpretation of the data, and N- and O-linked glycopeptides were assigned from separate searches. The identification rate was very low in all searches, even when results were combined...
May 5, 2018: Journal of the American Society for Mass Spectrometry
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