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Wesam Saleh A Al Attar, Najeebullah Soomro, Peter J Sinclair, Evangelos Pappas, Ross H Sanders
BACKGROUND: Hamstring injuries are among the most common non-contact injuries in sports. The Nordic hamstring (NH) exercise has been shown to decrease risk by increasing eccentric hamstring strength. OBJECTIVE: The purpose of this systematic review and meta-analysis was to investigate the effectiveness of the injury prevention programs that included the NH exercise on reducing hamstring injury rates while factoring in athlete workload. METHODS: Two researchers independently searched for eligible studies using the following databases: the Cochrane Central Register of Controlled Trials via OvidSP, AMED (Allied and Complementary Medicine) via OvidSP, EMBASE, PubMed, MEDLINE, SPORTDiscus, Web of Science, CINAHL and AusSportMed, from inception to December 2015...
October 17, 2016: Sports Medicine
Aliza K Llovet
The purpose of the activity reported in this article was to conduct an exhaustive search of the Journal of Music Therapy, filter the articles on the desired parameters, and organize data for analysis and interpretation. Specifically, the researcher studied whether (a) there was a significant difference in physiological measures, (b) there was a significant difference in quality of life, (c) there was a significant difference in satisfaction levels, (d) there was a significant difference in pain reduction, (e) there was a significant difference in procedural length, (f) there was a significant difference in length of stay, and (g) whether the overall effect size and 95% confidence level support the recommendation of music therapy in the health care setting...
September 30, 2016: Health Care Manager
András Lánczky, Ádám Nagy, Giulia Bottai, Gyöngyi Munkácsy, András Szabó, Libero Santarpia, Balázs Győrffy
PURPOSE: The proper validation of prognostic biomarkers is an important clinical issue in breast cancer research. MicroRNAs (miRNAs) have emerged as a new class of promising breast cancer biomarkers. In the present work, we developed an integrated online bioinformatic tool to validate the prognostic relevance of miRNAs in breast cancer. METHODS: A database was set up by searching the GEO, EGA, TCGA, and PubMed repositories to identify datasets with published miRNA expression and clinical data...
October 15, 2016: Breast Cancer Research and Treatment
Richa Barsainya, Tarun Kumar Rawat, Manjeet Kumar
In this paper, a novel design of fractional order differentiator (FOD) based on lattice wave digital filter (LWDF) is proposed which requires minimum number of multiplier for its structural realization. Firstly, the FOD design problem is formulated as an optimization problem using the transfer function of lattice wave digital filter. Then, three optimization algorithms, namely, genetic algorithm (GA), particle swarm optimization (PSO) and cuckoo search algorithm (CSA) are applied to determine the optimal LWDF coefficients...
October 12, 2016: ISA Transactions
Yi Zhou, Wenjuan Yu, Huan Zhong, Jianlin Li, Hongxia Li, Feng He, Jie Zhou, Yongkai Tang, Juhua Yu, Fan Yu
Common carp (Cyprinus carpio) is a widespread freshwater fish and economically important species in China and other East Asian countries. Recent studies suggest that insulin can alter the expression of immune genes and, thus, can be regarded as an immunomodulatory hormone. To understand the mechanism of the immune response to insulin, we performed a comparative RNA-seq transcriptome analysis using livers from common carp injected with insulin (5 μg/g bodyweight) or saline as a control. After filtering the low-quality reads and removing the adaptors, the clean raw reads were assembled into 60,421 unigenes with mean length of 746...
October 11, 2016: Fish & Shellfish Immunology
Jiangbo Lu, Yu Li, Hongsheng Yang, Dongbo Min, Weiyong Eng, Minh Do
Though many tasks in computer vision can be formulated elegantly as pixel-labeling problems, a typical challenge discouraging such a discrete formulation is often due to computational efficiency. Recent studies on fast cost volume filtering based on efficient edge-aware filters provide a fast alternative to solve discrete labeling problems, with the complexity independent of the support window size. However, these methods still have to step through the entire cost volume exhaustively, which makes the solution speed scale linearly with the label space size...
October 11, 2016: IEEE Transactions on Pattern Analysis and Machine Intelligence
Carlos Henrique Tomich de Paula da Silva, Carlton Anthony Taft
The knowledge of the bioactive conformation for an active hit is relevant because of the easier interpretation and the general quality of the recognition models of protein and ligand. With the aim of investigating potential bioactive conformations without previous structural knowledge of the molecular target, we present herewith a 'protocol' that could be used which includes generation of low-energy conformations, calculations of tridimensional descriptors and investigation of structural similarity via principal component analysis...
October 14, 2016: Journal of Biomolecular Structure & Dynamics
Zixing Wang, Yaoda Hu, Yuyan Wang, Wei Han, Lei Wang, Fang Xue, Xin Sui, Wei Song, Ruihong Shi, Jingmei Jiang
OBJECTIVES: To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there's universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach. MATERIALS AND METHODS: EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2...
2016: PloS One
Osmar A Cuoghi, Francielle Topolski, Lorraine P de Faria, Marcos R de Mendonça
AIM: To evaluate the correlation between pain and tissue damage in response to orthodontic tooth movement (OTM), such as hyalinization and external apical root resorption (EARR). MATERIALS AND METHODS: The literature review was used as a methodological strategy, following the knowledge development process - constructivist (ProKnow-C). Study axes were defined and keywords that best represented each axis were selected. The terms were submitted to an adherence test and validation, resulting in 12 keyword combinations...
September 1, 2016: Journal of Contemporary Dental Practice
Oleksa G Rewa, Pierre-Marc Villeneuve, Philippe Lachance, Dean T Eurich, Henry T Stelfox, R T Noel Gibney, Lisa Hartling, Robin Featherstone, Sean M Bagshaw
OBJECTIVES: Renal replacement therapy is increasingly utilized in the intensive care unit (ICU), of which continuous renal replacement therapy (CRRT) is most common. Despite CRRT being a relatively invasive and resource intensive technology, there remains wide practice variation in its application. This systematic review appraised the evidence for quality indicators (QIs) of CRRT care in critically ill patients. DESIGN: A comprehensive search strategy was developed and performed in five citation databases (Medline, Embase, CINAHL, Cochrane Library, and PubMed) and select grey literature sources...
October 11, 2016: Intensive Care Medicine
Eva Tyteca, Mohammad Talebi, Ruth Amos, Soo Hyun Park, Maryam Taraji, Yabin Wen, Roman Szucs, Christopher A Pohl, John W Dolan, Paul R Haddad
Quantitative Structure-Retention Relationships (QSRR) have the potential to speed up the screening phase of chromatographic method development as the initial exploratory experiments are replaced by prediction of analyte retention based solely on the structure of the molecule. The present study offers further proof-of-concept of localized QSRR modelling, in which the retention of any given compound is predicted using only the most chromatographically similar compounds in the available dataset. To this end, each compound in the dataset was sequentially removed from the database and individually utilized as a test analyte...
September 27, 2016: Journal of Chromatography. A
Nicholas Thapen, Donal Simmie, Chris Hankin
BACKGROUND: Twitter updates now represent an enormous stream of information originating from a wide variety of formal and informal sources, much of which is relevant to real-world events. They can therefore be highly useful for event detection and situational awareness applications. RESULTS: In this paper we apply customised filtering techniques to existing bio-surveillance algorithms to detect localised spikes in Twitter activity, showing that these correspond to real events with a high level of confidence...
October 7, 2016: Journal of Biomedical Semantics
Barry K Lavine, Collin G White, Matthew D Allen, Andrew Weakley
Multilayered automotive paint fragments, which are one of the most complex materials encountered in the forensic science laboratory, provide crucial links in criminal investigations and prosecutions. To determine the origin of these paint fragments, forensic automotive paint examiners have turned to the paint data query (PDQ) database, which allows the forensic examiner to compare the layer sequence and color, texture, and composition of the sample to paint systems of the original equipment manufacturer (OEM)...
October 5, 2016: Applied Spectroscopy
Wei Shen, Shuai Le, Yan Li, Fuquan Hu
FASTA and FASTQ are basic and ubiquitous formats for storing nucleotide and protein sequences. Common manipulations of FASTA/Q file include converting, searching, filtering, deduplication, splitting, shuffling, and sampling. Existing tools only implement some of these manipulations, and not particularly efficiently, and some are only available for certain operating systems. Furthermore, the complicated installation process of required packages and running environments can render these programs less user friendly...
2016: PloS One
Mitsuhiro Fujishiro, Shuntaro Yoshida, Rie Matsuda, Akiko Narita, Hiroharu Yamashita, Yasuyuki Seto
BACKGROUND: Endoscopic resection for early gastric cancer (EGC) plays a central role in the treatment of EGC in Japan. However, there is still room for improvement, and it is necessary to summarize the recently obtained knowledge from Japan for further improvement. METHODS: We conducted a PubMed search to select relevant articles in the 5 years until September 18, 2016, using the keywords "gastric cancer" and "endoscopic treatment," "endoscopic submucosal dissection," "endoscopic mucosal resection," or "polypectomy" and filtering article types as "clinical study" or "clinical trial...
October 4, 2016: Gastric Cancer
Joanne Jordan, Louise Rose, Katie N Dainty, Jane Noyes, Bronagh Blackwood
BACKGROUND: Prolonged mechanical ventilation is associated with a longer intensive care unit (ICU) length of stay and higher mortality. Consequently, methods to improve ventilator weaning processes have been sought. Two recent Cochrane systematic reviews in ICU adult and paediatric populations concluded that protocols can be effective in reducing the duration of mechanical ventilation, but there was significant heterogeneity in study findings. Growing awareness of the benefits of understanding the contextual factors impacting on effectiveness has encouraged the integration of qualitative evidence syntheses with effectiveness reviews, which has delivered important insights into the reasons underpinning (differential) effectiveness of healthcare interventions...
October 4, 2016: Cochrane Database of Systematic Reviews
Clemens Scott Kruse, Benjamin Frederick, Taylor Jacobson, D Kyle Monticone
BACKGROUND: The adoption of healthcare technology is arduous, and it requires planning and implementation time. Healthcare organizations are vulnerable to modern trends and threats because it has not kept up with threats. OBJECTIVE: The objective of this systematic review is to identify cybersecurity trends, including ransomware, and identify possible solutions by querying academic literature. METHODS: The reviewers conducted three separate searches through the CINAHL and PubMed (MEDLINE) and the Nursing and Allied Health Source via ProQuest databases...
September 20, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Angélique Vétillard, Wafa Bouzid
Animal venoms are complex mixtures containing simple organic molecules, proteins, peptides, and other bioactive elements with extraordinary biological properties associated with their ability to act on a number of molecular receptors in the process of incapacitating their target organisms. In such a context, arthropod venoms are invaluable sources of bioactive substances, with therapeutic interest but the limited availability of some venom such as those from ants, has restricted the potential that these biomolecules could represent...
2016: Biologie Aujourd'hui
Yanhua Xu, Jiye Xie
OBJECTIVE: To compare the treatment effects of mini-implants as anchor units with conventional methods of anchorage reinforcement in maxillary dentoalveolar protrusion patients in terms of skeletal, dental, and soft tissue changes. MATERIALS AND METHODS: We searched the databases of the Cochrane Library, PubMed, OVIDSP, CBM, VIP, WanFang Data, and CNKI covering December 1966 to March 2016 for randomized controlled trials (RCTs) and clinical controlled trials that compared the treatment effects of mini-implants with conventional anchorage reinforcement in maxillary dentoalveolar protrusion patients...
September 29, 2016: Angle Orthodontist
Krishna S Vyas, Sibi Rajendran, Shane D Morrison, Afaaf Shakir, Samir Mardini, Valerie Lemaine, Maurice Y Nahabedian, Stephen B Baker, Brian D Rinker, Henry C Vasconez
BACKGROUND: Management of postoperative pain often requires multimodal approaches. Suboptimal dosages of current therapies can leave patients experiencing periods of insufficient analgesia, often requiring rescue therapy. With absence of a validated and standardized approach to pain management, further refinement of treatment protocols and targeted therapeutics is needed. Liposomal bupivacaine (Exparel) is a longer acting form of traditional bupivacaine that delivers the drug by means of a multivesicular liposomal system...
October 2016: Plastic and Reconstructive Surgery
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