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https://www.readbyqxmd.com/read/28546863/ecg-signal-analysis-using-modified-s-transform
#1
Birendra Biswal
Accurate detection of QRS complexes is essential for the investigation of heart rate variability. Several transform techniques have been proposed and extensively used for the detection and analysis of QRS complexes. In this proposed work, the de-noised ECG signal is subjected to a modified S-transform for QRS complex detection.The performance analysis of the proposed work is evaluated using parameters such as sensitivity, positive predictivity and accuracy. The algorithm delivers sensitivity, positive predictivity and overall accuracy of 99...
April 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28542266/underwater-sonar-image-detection-a-combination-of-non-local-spatial-information-and-quantum-inspired-shuffled-frog-leaping-algorithm
#2
Xingmei Wang, Shu Liu, Zhipeng Liu
This paper proposes a combination of non-local spatial information and quantum-inspired shuffled frog leaping algorithm to detect underwater objects in sonar images. Specifically, for the first time, the problem of inappropriate filtering degree parameter which commonly occurs in non-local spatial information and seriously affects the denoising performance in sonar images, was solved with the method utilizing a novel filtering degree parameter. Then, a quantum-inspired shuffled frog leaping algorithm based on new search mechanism (QSFLA-NSM) is proposed to precisely and quickly detect sonar images...
2017: PloS One
https://www.readbyqxmd.com/read/28537071/clmsvault-a-software-suite-for-protein-cross-linking-mass-spectrometry-data-analysis-and-visualization
#3
Mathieu Courcelles, Jasmin Coulombe-Huntington, Émilie Cossette, Anne-Claude Gingras, Pierre Thibault, Michael Tyers
Protein cross-linking mass spectrometry (CL-MS) enables the sensitive detection of protein interactions and the inference of protein complex topology. The detection of chemical cross-links between protein residues can identify intra- and inter-protein contact sites and/or provide physical constraints for molecular modeling of protein structure. Recent innovations in cross-linker design, sample preparation, mass spectrometry and software tools have significantly improved CL-MS approaches. Although a number of algorithms now exist for the identification of cross-linked peptides from mass spectral data, a dearth of user-friendly analysis tools represent a practical bottleneck to the broad adoption of the approach...
May 24, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28532469/a-pipeline-combining-multiple-strategies-for-prioritizing-heterozygous-variants-for-the-identification-of-candidate-genes-in-exome-datasets
#4
Teresa Requena, Alvaro Gallego-Martinez, Jose A Lopez-Escamez
BACKGROUND: The identification of disease-causing variants in autosomal dominant diseases using exome-sequencing data remains a difficult task in small pedigrees. We combined several strategies to improve filtering and prioritizing of heterozygous variants using exome-sequencing datasets in familial Meniere disease: an in-house Pathogenic Variant (PAVAR) score, the Variant Annotation Analysis and Search Tool (VAAST-Phevor), Exomiser-v2, CADD, and FATHMM. We also validated the method by a benchmarking procedure including causal mutations in synthetic exome datasets...
May 22, 2017: Human Genomics
https://www.readbyqxmd.com/read/28531115/a-low-complexity-doa-and-polarization-method-of-polarization-sensitive-array
#5
Wen Dong, Ming Diao, Lipeng Gao, Lutao Liu
This paper proposes a low-complexity method to estimate the direction of arrival and polarization based on the polarization sensitive array (PSA) which is composed of cross-dipoles. We built a half-quaternions model through the Cayley-Dickson form to remove the redundant information. Then, the directions of arrival (DOAs) were estimated via the root-MUSIC algorithm. Finally, the polarizations were estimated by generalized eigenvalue method. Unlike some existing searching algorithms, such as multiple signal classification (MUSIC), this method can avoid the peak searching and maintains high estimation accuracy...
May 20, 2017: Sensors
https://www.readbyqxmd.com/read/28520890/vcf-filter-interactive-prioritization-of-disease-linked-genetic-variants-from-sequencing-data
#6
Heiko Müller, Raul Jimenez-Heredia, Ana Krolo, Tatjana Hirschmugl, Jasmin Dmytrus, Kaan Boztug, Christoph Bock
Next generation sequencing is widely used to link genetic variants to diseases, and it has massively accelerated the diagnosis and characterization of rare genetic diseases. After initial bioinformatic data processing, the interactive analysis of genome, exome, and panel sequencing data typically starts from lists of genetic variants in VCF format. Medical geneticists filter and annotate these lists to identify variants that may be relevant for the disease under investigation, or to select variants that are reported in a clinical diagnostics setting...
May 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28520535/optimal-z-score-use-in-surgical-decision-making-in-pulmonary-atresia-with-intact-ventricular-septum
#7
Mark Nelson Awori, Nikita P Mehta, Frederick O Mitema, Naomi Kebba
OBJECTIVES: In the surgical treatment of pulmonary atresia with intact ventricular septum, the size of the tricuspid valve annulus (as measured by z-scores) has emerged as a significant factor in deciding which repair to perform. Various tricuspid valve annulus z-scores are reported as "cutoffs" for successful biventricular repair. We aimed to determine whether the use of different z-score data sets contributed to the gross variation in "cutoffs" for successful biventricular repair reported in the literature...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28520403/integrated-strategy-for-unknown-ei-ms-identification-using-quality-control-calibration-curve-multivariate-analysis-ei-ms-spectral-database-and-retention-index-prediction
#8
Teruko Matsuo, Hiroshi Tsugawa, Hiromi Miyagawa, Eiichiro Fukusaki
Compound identification using unknown electron ionization (EI) mass spectra in gas chromatography coupled with mass spectrometry (GC-MS) is challenging in untargeted metabolomics, natural product chemistry, or exposome research. While the total count of EI-MS records included in publicly or commercially available databases is over 900 000, efficient use of this huge database has not been achieved in metabolomics. Therefore, we proposed a "four-step" strategy for the identification of biologically significant metabolites using an integrated cheminformatics approach: (i) quality control calibration curve to reduce background noise, (ii) variable selection by hypothesis testing in principal component analysis for the efficient selection of target peaks, (iii) searching the EI-MS spectral database, and (iv) retention index (RI) filtering in combination with RI predictions...
May 26, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28508816/physicians-use-of-online-clinical-evidence-in-mashhad-university-of-medical-sciences-iran
#9
Masoumeh Sarbaz, Khalil Kimiafar, Alireza Banaye Yazdipour
The Internet is an important source of medical information. It is expected that the use of online sources will improve clinical decisions. This study aims to evaluate online information seeking behavior of physicians of Mashhad University of Medical Sciences on the use of online clinical evidence. A cross-sectional, questionnaire-based study was carried out between November and December 2014 in the five academic hospitals. A total of 252 physicians completed the questionnaire. The majority of physicians (63...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506863/the-null-test-for-peptide-identification-algorithm-in-shotgun-proteomics
#10
Shu-Rong Zhang, Yi-Chu Shan, Hao Jiang, Jian-Hui Liu, Yuan Zhou, Li-Hua Zhang, Yu-Kui Zhang
The present research proposed general evaluation strategy named Null-Test for peptide identification algorithm in Shotgun proteomics. The Null-Test method based on random matching can be utilized to check whether the algorithm has a tendency to make a mistake or has potential bugs, faultiness, errors etc., and to validate the reliability of the identification algorithm. Unfortunately, none of the five famous identification software could pass the most stringent Null-Test. PatternLab had good performance in both Null-Test and routine search by making a good control on the overfitting with sound design...
May 12, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28504951/a-sequential-learning-approach-for-scaling-up-filter-based-feature-subset-selection
#11
Gregory Ditzler, Robi Polikar, Gail Rosen
Increasingly, many machine learning applications are now associated with very large data sets whose sizes were almost unimaginable just a short time ago. As a result, many of the current algorithms cannot handle, or do not scale to, today's extremely large volumes of data. Fortunately, not all features that make up a typical data set carry information that is relevant or useful for prediction, and identifying and removing such irrelevant features can significantly reduce the total data size. The unfortunate dilemma, however, is that some of the current data sets are so large that common feature selection algorithms-whose very goal is to reduce the dimensionality-cannot handle such large data sets, creating a vicious cycle...
May 11, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28503105/neurobiological-evidence-for-the-primacy-of-mania-hypothesis
#12
REVIEW
Georgios D Kotzalidis, Chiara Rapinesi, Valeria Savoja, Ilaria Cuomo, Alessio Simonetti, Elisa Ambrosi, Isabella Panaccione, Silvia Gubbini, Pietro De Rossi, Lavinia De Chiara, Delfina Janiri, Gabriele Sani, Alexia E Koukopoulos, Giovanni Manfredi, Flavia Napoletano, Matteo Caloro, Lucia Pancheri, Antonella Puzella, Gemma Callovini, Gloria Angeletti, Antonio Del Casale
BACKGROUND: Athanasios Koukopoulos proposed the primacy of mania hypothesis (PoM) in a 2006 book chapter and later, in two peer-reviewed papers with Nassir Ghaemi and other collaborators. This hypothesis supports that in bipolar disorder, mania leads to depression, while depression does not lead to mania. OBJECTIVE: To identify evidence in literature that supports or falsifies this hypothesis. METHOD: We searched the medical literature (PubMed, Embase, PsycINFO, and the Cochrane Library) for peer-reviewed papers on the primacy of mania, the default mode function of the brain in normal people and in bipolar disorder patients, and on illusion superiority until 6 June, 2016...
April 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28502688/evaluating-outcomes-of-stand-alone-anterior-lumbar-interbody-fusion-a-systematic-review
#13
Gloria Giang, Ralph Mobbs, Steven Phan, Tommy Manh Tran, Kevin Phan
BACKGROUND: Stand-alone anterior lumbar interbody fusion (ALIF) is an effective surgical approach for selected spinal pathologies. It avoids the morbidity and complications associated with instrumented ALIF such as plate fixation and the traditionally used posterior approach. Despite improved disc space visualisation and clearance, the associated posterior instability and increased risk of non-fusion present major challenges to this approach. The integral cage design aims to address these challenges by providing the necessary stabilisation through intracorporeal screws...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28498870/brg1-chromatin-remodeling-atpase-balances-germ-layer-patterning-by-amplifying-the-transcriptional-burst-at-midblastula-transition
#14
Gabriele Wagner, Nishant Singhal, Dario Nicetto, Tobias Straub, Elisabeth Kremmer, Ralph A W Rupp
Zygotic gene expression programs control cell differentiation in vertebrate development. In Xenopus, these programs are initiated by local induction of regulatory genes through maternal signaling activities in the wake of zygotic genome activation (ZGA) at the midblastula transition (MBT). These programs lay down the vertebrate body plan through gastrulation and neurulation, and are accompanied by massive changes in chromatin structure, which increasingly constrain cellular plasticity. Here we report on developmental functions for Brahma related gene 1 (Brg1), a key component of embyronic SWI/SNF chromatin remodeling complexes...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28498612/design-of-a-modulated-orthovoltage-stereotactic-radiosurgery-system
#15
Jessica M Fagerstrom, Edward T Bender, Michael J Lawless, Wesley S Culberson
PURPOSE: To achieve stereotactic radiosurgery (SRS) dose distributions with sharp gradients using orthovoltage energy fluence modulation with inverse planning optimization techniques. METHODS: A pencil beam model was used to calculate dose distributions from an orthovoltage unit at 250 kVp. Kernels for the model were derived using Monte Carlo methods. A Genetic Algorithm search heuristic was used to optimize the spatial distribution of added tungsten filtration to achieve dose distributions with sharp dose gradients...
May 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28488460/the-efficacy-of-evolocumab-in-the-management-of-hyperlipidemia-a-systematic-review
#16
Lamia AlHajri, Asma AlHadhrami, Shama AlMheiri, Yalwah AlMutawa, Zainab AlHashimi
BACKGROUND: Hyperlipidemia or dyslipidemia has been a concern for a long time, with various guidelines emphasizing the importance of managing the lipid profile to prevent cardiac incidences. Although statins have been found to be highly effective, resistance and intolerability to side effects will continue to be a stumbling block for certain patients. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors tackle lipid profile via a novel mechanism and therefore provide an additional effective option for managing lipid profile...
May 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28487831/a-new-parallel-approach-for-accelerating-the-gpu-based-execution-of-edge-detection-algorithms
#17
Zahra Emrani, Soroosh Bateni, Hossein Rabbani
Real-time image processing is used in a wide variety of applications like those in medical care and industrial processes. This technique in medical care has the ability to display important patient information graphi graphically, which can supplement and help the treatment process. Medical decisions made based on real-time images are more accurate and reliable. According to the recent researches, graphic processing unit (GPU) programming is a useful method for improving the speed and quality of medical image processing and is one of the ways of real-time image processing...
January 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28487275/a-phenome-database-neauhlfpd-designed-and-constructed-for-broiler-lines-divergently-selected-for-abdominal-fat-content
#18
Li Min, Dong Xiangyu, Liang Hao, Leng Li, Zhang Hui, Wang Shouzhi, Li Hui, Du Zhi-Qiang
Effective management and analysis of precisely recorded phenotypic traits are important components of the selection and breeding of superior livestocks. Over two decades, we divergently selected chicken lines for abdominal fat content at Northeast Agricultural University (Northeast Agricultural University High and Low Fat, NEAUHLF), and collected large volume of phenotypic data related to the investigation on molecular genetic basis of adipose tissue deposition in broilers. To effectively and systematically store, manage and analyze phenotypic data, we built the NEAUHLF Phenome Database (NEAUHLFPD)...
May 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28483467/the-effect-of-social-media-some-on-journal-impact-factor-and-parental-awareness-in-paediatric-urology
#19
F O'Kelly, G J Nason, R P Manecksha, S Cascio, F J Quinn, M Leonard, M A Koyle, W Farhat, M J Leveridge
BACKGROUND: Social media (SoMe) comprises a number of internet-based applications that have the capability to disseminate multimodal media and allow for unprecedented inter-user connectivity. The role of Twitter has been studied in conferences and education; moreover, there is increasing evidence that patients are more likely to use social media for their own health education. OBJECTIVE: The aim of this study was to assess the impact of social media platforms on the impact factor of both urological and paediatric journals that publish on paediatric urology, and to assess parental awareness of social media in paediatric urology...
April 21, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28482459/synthetic-fibers-as-microplastics-in-the-marine-environment-a-review-from-textile-perspective-with-a-focus-on-domestic-washings
#20
REVIEW
Flavia Salvador Cesa, Alexander Turra, Julia Baruque-Ramos
The ubiquity of plastic materials in the environment has been, for long, a matter of discussion. Smaller particles, named microplastics (<5mm), gained attention more recently and are now the focus of many studies, especially for their particularities regarding sources, characteristics and effects (e.g., surface-area-to-volume ratio which can increase their potential to transport toxic substances). Fibers from textile materials are a subgroup of microplastics and can be originated from domestic washings, as machine filters and wastewater treatment plants (WWTPs) are not specifically designed to retain them...
May 2, 2017: Science of the Total Environment
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