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https://www.readbyqxmd.com/read/28098939/a-systematic-review-of-economic-evaluations-of-treatments-for-patients-with-epilepsy
#1
REVIEW
Ben F M Wijnen, Ghislaine A P G van Mastrigt, Silvia M A A Evers, Olga Gershuni, Danielle A J E Lambrechts, Marian H J M Majoie, Debby Postulart, Bert A P Aldenkamp, Reina J A de Kinderen
The increasing number of treatment options and the high costs associated with epilepsy have fostered the development of economic evaluations in epilepsy. It is important to examine the availability and quality of these economic evaluations and to identify potential research gaps. As well as looking at both pharmacologic (antiepileptic drugs [AEDs]) and nonpharmacologic (e.g., epilepsy surgery, ketogenic diet, vagus nerve stimulation) therapies, this review examines the methodologic quality of the full economic evaluations included...
January 18, 2017: Epilepsia
https://www.readbyqxmd.com/read/28095810/neonatal-screening-for-congenital-adrenal-hyperplasia-in-southern-brazil-a-population-based-study-with-108-409-infants
#2
Cristiane Kopacek, Simone Martins de Castro, Mayara Jorgens Prado, Claudia Maria Dornelles da Silva, Luciana Amorim Beltrão, Poli Mara Spritzer
BACKGROUND: Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder associated with inborn errors of steroid metabolism. 21-hydroxylase enzyme deficiency occurs in 90 to 95% of all cases of CAH, with accumulation of 17 hydroxyprogesterone (17-OHP). Early diagnosis of CAH based on newborn screening is possible before the development of symptoms and allows proper treatment, correct sex assignment, and reduced mortality rates. This study describes the results obtained in the first year of a public CAH screening program in the state of Rio Grande do Sul, Brazil...
January 17, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28092532/improved-shear-wave-group-velocity-estimation-method-based-on-spatiotemporal-peak-and-thresholding-motion-search
#3
Carolina Amador Carrascal, Shigao Chen, Armando Manduca, James F Greenleaf, Matthew Urban
Quantitative ultrasound elastography is increasingly being used in the assessment of chronic liver disease. Many studies have reported ranges of liver shear wave velocities values for healthy individuals and patients with different stages of liver fibrosis. Nonetheless, ongoing efforts exist to stabilize quantitative ultrasound elastography measurements by assessing factors that influence tissue shear wave velocity values, such as food intake, body mass index (BMI), ultrasound scanners, scanning protocols, ultrasound image quality, etc...
January 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28088798/the-intracranial-b2leed3s-score-and-the-risk-of-intracranial-hemorrhage-in-ischemic-stroke-patients-under-antiplatelet-treatment
#4
Pierre Amarenco, Leila Sissani, Julien Labreuche, Eric Vicaut, Marie Germaine Bousser, Angel Chamorro, Marc Fisher, Ian Ford, Kim M Fox, Michael G Hennerici, Heinrich Mattle, Peter M Rothwell, Philippe Gabriel Steg, Hans-Christoph Diener, Ralph L Sacco, Jacoba P Greving, Ale Algra
BACKGROUND: Chronic antiplatelet therapy in the post-acute phase of non-cardioembolic ischemic stroke is limited by the risk of intracranial hemorrhage (ICH) complications. METHODS: We developed an ICH risk score based on the PERFORM trial cohort (n = 19,100), which included patients with a non-cardioembolic ischemic stroke or transient ischemic attack, and externally validated this score in one contemporary trial of very similar size and inclusion criteria, the PRoFESS trial (n = 20,332 patients)...
January 14, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28070751/case-control-studies-in-diabetes-do-they-really-use-a-case-control-design
#5
Analía Ramos, Lilian Cristina Mendoza, Fernanda Rabasa, Ignasi Bolíbar, Teresa Puig, Rosa Corcoy
AIMS: Studies defined as case-control do not always use this design. We aimed to estimate the frequency of mislabelled case-control studies in published articles in the area of diabetes and to identify the predictors of incorrect labelling. METHODS: We searched Medline and Web of Science for articles with "diabetes" and "case control" in title and filtered for language (English/Romance) and period (January 2010-December 2014). Inclusion criteria were: (1) statement to use a case-control design in title, (2) to be a final full-length publication and (3) to have original data in the area of diabetes...
January 9, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28070683/do-we-have-the-right-proms-for-measuring-outcomes-in-lumbar-spinal-surgery
#6
REVIEW
O M Stokes, A A Cole, L M Breakwell, A J Lloyd, C M Leonard, M Grevitt
PURPOSE: Patient-reported outcome measures (PROMs) have become an important part of routine auditing of outcomes in spinal surgery in the UK. PROMs can be used to help assess the quality of care provided by surgical units by determining the comparative health status of patients, before and after surgery. This study was designed to review the PROMs used to assess outcomes in spinal surgery and to determine if they are fit for the purpose. METHODS: A systematic literature search was undertaken to identify studies that reported PROMs data following lumbar spinal surgery...
January 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28069918/posterior-alpha-eeg-dynamics-dissociate-current-from-future-goals-in-working-memory-guided-visual-search
#7
Ingmar E J de Vries, Joram van Driel, Christian N L Olivers
: Current models of visual search assume that search is guided by an active visual working memory representation of what we are currently looking for. This attentional template for currently relevant stimuli can be dissociated from accessory memory representations that are only needed prospectively, for a future task, and that should be prevented from guiding current attention. However, it remains unclear what electrophysiological mechanisms dissociate currently relevant (serving upcoming selection) from prospectively relevant memories (serving future selection)...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28067860/3d-visual-tracking-of-an-articulated-robot-in-precision-automated-tasks
#8
Hamza Alzarok, Simon Fletcher, Andrew P Longstaff
The most compelling requirements for visual tracking systems are a high detection accuracy and an adequate processing speed. However, the combination between the two requirements in real world applications is very challenging due to the fact that more accurate tracking tasks often require longer processing times, while quicker responses for the tracking system are more prone to errors, therefore a trade-off between accuracy and speed, and vice versa is required. This paper aims to achieve the two requirements together by implementing an accurate and time efficient tracking system...
January 7, 2017: Sensors
https://www.readbyqxmd.com/read/28062516/systems-thinking-in-public-health-a-bibliographic-contribution-to-a-meta-narrative-review
#9
Saad Chughtai, Karl Blanchet
BACKGROUND: Research across the formal, natural and social sciences has greatly expanded our knowledge about complex systems in recent decades, informing a broadly inclusive, cross-disciplinary conceptual framework referred to as Systems Thinking (ST). Its use in public health is rapidly increasing, although there remains a poor understanding of how these ideas have been imported, adapted and elaborated by public health research networks worldwide. METHOD: This review employed a mixed methods approach to narrate the development of ST in public health...
January 6, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28060869/evaluation-of-the-quality-of-reporting-of-observational-studies-in-otorhinolaryngology-based-on-the-strobe-statement
#10
Martine Hendriksma, Michiel H M A Joosten, Jeroen P M Peters, Wilko Grolman, Inge Stegeman
BACKGROUND: Observational studies are the most frequently published studies in literature. When randomized controlled trials cannot be conducted because of ethical or practical considerations, an observational study design is the first choice. The STROBE Statement (STrengthening the Reporting of OBservational studies in Epidemiology) was developed to provide guidance on how to adequately report observational studies. OBJECTIVES: The objectives were 1) to evaluate the quality of reporting of observational studies of otorhinolaryngologic literature using the STROBE Statement checklist, 2) to compare the quality of reporting of observational studies in the top 5 Ear, Nose, Throat (ENT) journals versus the top 5 general medical journals and 3) to formulate recommendations to improve adequate reporting of observational research in otorhinolaryngologic literature...
2017: PloS One
https://www.readbyqxmd.com/read/28048832/su-f-p-43-use-of-freeware-business-intelligence-software-to-trend-tg-142-compliant-linac-qa-parameters
#11
A Ayan, D DiCostanzo, J Woollard, N Gupta
PURPOSE: To develop a software platform to track linac QA parameter trends using readily available freeware business intelligence (BI) software METHODS: Spreadsheets were used to collect QA data by many, if not all, institutions; but the trending analysis with data from separate spreadsheets could be a cumbersome task. A freeware version of the Microsoft Power BI software was adapted to trend linac QA parameters to allow us to maintain nine dosimetrically equivalent linacs. A monthly QA spreadsheet (Microsoft Excel) has been used in our institution to collect QA data...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048406/su-g-iep2-01-a-method-to-reduce-information-loss-in-jpeg-compressed-medical-images-using-richardson-lucy-deconvolution
#12
Y Choi, M Han, J Baek
PURPOSE: To minimize the information loss of medical images compressed by JPEG using Richardson-Lucy (RL) deconvolution. METHODS: We first generated reference images having three different noise structures; low-passed noise, high-passed noise, and white noise, which mimic noise structures for different medical imaging modalities. Each reference image was filtered by a Gaussian function and compressed/decompressed by JPEG 2000 algorithm. After decompression, RL deconvolution was applied to recover the reference image using the same Gaussian function...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048151/su-f-r-43-recursive-k-means-filter-for-preserving-signals-of-interest
#13
A Chu, P Yan, R Shih, C Wuu
PURPOSE: To use recursive cluster analysis to filter noises and artifacts out of useful signals. The method was applied to CT or CBCT for preserving interested low Hounsfield Unit (HU) signals such as lung tissues while the HU of lung tissues is often overlapped with CT (or CBCT) artifacts. METHODS: Cluster analysis is to search for the similarity among data points, which could employ multi-dimensional techniques. For our purpose, we searched for a robust, fast, and automatic process for sorting interested low HU object in CT, Therefore, 1-D cluster analysis is suitable for the purpose...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048043/su-f-j-212-enabling-conventional-cone-beam-ct-with-the-capability-of-dual-energy-imaging-using-a-simple-add-on-beam-modifier
#14
R Vinke, S Takao, K Umegaki, H Shirato, H Peng, L Xing
PURPOSE: In searching for a robust, efficient and cost-effective dual energy cone beam CT (DECBCT) solution for various radiation oncology applications, in particularly for improved proton dose planning/replanning accuracy and DE-CBCT guided radiation therapy, we investigate a novel energy modulation scheme using a beam modifier placed between the source and patient and optimize its geometric configuration for routine clinical use. METHODS: The study was performed using a Hitachi CBCT scanner and the tube voltage was set at 125 kVp...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047435/mo-de-bra-06-3d-image-acquisition-and-reconstruction-explained-with-online-animations
#15
A Kesner
PURPOSE: Understanding the principles of 3D imaging and image reconstruction is fundamental to the field of medical imaging. Clinicians, technologists, physicists, patients, students, and inquisitive minds all stand to benefit from greater comprehension of the supporting technologies. To help explain the basic principles of 3D imaging, we developed multi-frame animations that convey the concepts of tomographic imaging. The series of free (gif) animations are accessible online, and provide a multimedia introduction to the main concepts of image reconstruction...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047197/tu-h-brc-05-stereotactic-radiosurgery-optimized-with-orthovoltage-beams
#16
J Fagerstrom, E Bender, W Culberson
PURPOSE: To achieve improved stereotactic radiosurgery (SRS) dose distributions using orthovoltage energy fluence modulation with inverse planning optimization techniques. METHODS: A pencil beam model was used to calculate dose distributions from the institution's orthovoltage unit at 250 kVp. Kernels for the model were derived using Monte Carlo methods as well as measurements with radiochromic film. The orthovoltage photon spectra, modulated by varying thicknesses of attenuating material, were approximated using open-source software...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046911/mo-de-207a-11-sparse-view-ct-reconstruction-via-a-novel-non-local-means-method
#17
Z Chen, H Qi, S Wu, Y Xu, L Zhou
PURPOSE: Sparse-view computed tomography (CT) reconstruction is an effective strategy to reduce the radiation dose delivered to patients. Due to its insufficiency of measurements, traditional non-local means (NLM) based reconstruction methods often lead to over-smoothness in image edges. To address this problem, an adaptive NLM reconstruction method based on rotational invariance (RIANLM) is proposed. METHODS: The method consists of four steps: 1) Initializing parameters; 2) Algebraic reconstruction technique (ART) reconstruction using raw projection data; 3) Positivity constraint of the image reconstructed by ART; 4) Update reconstructed image by using RIANLM filtering...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046783/su-f-t-20-novel-catheter-lumen-recognition-algorithm-for-rapid-digitization
#18
J Dise, D McDonald, M Ashenafi, J Peng, C Mart, N Koch, K Vanek
PURPOSE: Manual catheter recognition remains a time-consuming aspect of high-dose-rate brachytherapy (HDR) treatment planning. In this work, a novel catheter lumen recognition algorithm was created for accurate and rapid digitization. METHODS: MatLab v8.5 was used to create the catheter recognition algorithm. Initially, the algorithm searches the patient CT dataset using an intensity based k-means filter designed to locate catheters. Once the catheters have been located, seed points are manually selected to initialize digitization of each catheter...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046771/su-f-j-93-automated-segmentation-of-high-resolution-3d-wholebrain-spectroscopic-mri-for-glioblastoma-treatment-planning
#19
E Schreibmann, J Cordova, S Gurbani, C Holder, L Cooper, H Shu, H Shim
PURPOSE: We report on an automated segmentation algorithm for defining radiation therapy target volumes using spectroscopic MR images (sMRI) acquired at nominal voxel resolution of 100 microliters. METHODS: Wholebrain sMRI combining 3D echo-planar spectroscopic imaging, generalized auto-calibrating partially-parallel acquisitions, and elliptical k-space encoding were conducted on 3T MRI scanner with 32-channel head coil array creating images. Metabolite maps generated include choline (Cho), creatine (Cr), and N-acetylaspartate (NAA), as well as Cho/NAA, Cho/Cr, and NAA/Cr ratio maps...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042699/development-and-testing-of-a-medline-search-filter-for-identifying-patient-and-public-involvement-in-health-research
#20
Morwenna Rogers, Alison Bethel, Kate Boddy
BACKGROUND: Research involving the public as partners often proves difficult to locate due to the variations in terms used to describe public involvement, and inability of medical databases to index this concept effectively. OBJECTIVE: To design a search filter to identify literature where patient and public involvement (PPI) was used in health research. METHODS: A reference standard of 172 PPI papers was formed. The references were divided into a development set and a test set...
January 1, 2017: Health Information and Libraries Journal
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