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https://www.readbyqxmd.com/read/29132349/measurement-properties-of-comorbidity-indices-in-maternal-health-research-a-systematic-review
#1
Kazuyoshi Aoyama, Rohan D'Souza, Eiichi Inada, Stephen E Lapinsky, Robert A Fowler
BACKGROUND: Maternal critical illness occurs in 1.2 to 4.7 of every 1000 live births in the United States and approximately 1 in 100 women who become critically ill will die. Patient characteristics and comorbid conditions are commonly summarized as an index or score for the purpose of predicting the likelihood of dying; however, most such indices have arisen from non-pregnant patient populations. We sought to systematically review comorbidity indices used in health administrative datasets of pregnant women, in order to critically appraise their measurement properties and recommend optimal tools for clinicians and maternal health researchers...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29126202/activedriverdb-human-disease-mutations-and-genome-variation-in-post-translational-modification-sites-of-proteins
#2
Michal Krassowski, Marta Paczkowska, Kim Cullion, Tina Huang, Irakli Dzneladze, B F Francis Ouellette, Joseph T Yamada, Amelie Fradet-Turcotte, Jüri Reimand
Interpretation of genetic variation is needed for deciphering genotype-phenotype associations, mechanisms of inherited disease, and cancer driver mutations. Millions of single nucleotide variants (SNVs) in human genomes are known and thousands are associated with disease. An estimated 21% of disease-associated amino acid substitutions corresponding to missense SNVs are located in protein sites of post-translational modifications (PTMs), chemical modifications of amino acids that extend protein function. ActiveDriverDB is a comprehensive human proteo-genomics database that annotates disease mutations and population variants through the lens of PTMs...
November 8, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29125628/genomics-based-non-invasive-prenatal-testing-for-detection-of-fetal-chromosomal-aneuploidy-in-pregnant-women
#3
REVIEW
Mylène Badeau, Carmen Lindsay, Jonatan Blais, Leon Nshimyumukiza, Yemisi Takwoingi, Sylvie Langlois, France Légaré, Yves Giguère, Alexis F Turgeon, William Witteman, François Rousseau
BACKGROUND: Common fetal aneuploidies include Down syndrome (trisomy 21 or T21), Edward syndrome (trisomy 18 or T18), Patau syndrome (trisomy 13 or T13), Turner syndrome (45,X), Klinefelter syndrome (47,XXY), Triple X syndrome (47,XXX) and 47,XYY syndrome (47,XYY). Prenatal screening for fetal aneuploidies is standard care in many countries, but current biochemical and ultrasound tests have high false negative and false positive rates. The discovery of fetal circulating cell-free DNA (ccfDNA) in maternal blood offers the potential for genomics-based non-invasive prenatal testing (gNIPT) as a more accurate screening method...
November 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29119240/ivc-filter-placements-in-children-nationwide-comparison-of-practice-patterns-at-adult-and-children-s-hospitals-using-the-kids-inpatient-database
#4
Vibhor Wadhwa, Premal S Trivedi, Sumera Ali, Robert K Ryu, Amir Pezeshkmehr
BACKGROUND: Inferior vena cava (IVC) filter placement in children has been described in literature, but there is variability with regard to their indications. No nationally representative study has been done to compare practice patterns of filter placements at adult and children's hospitals. OBJECTIVE: To perform a nationally representative comparison of IVC filter placement practices in children at adult and children's hospitals. MATERIALS AND METHODS: The 2012 Kids' Inpatient Database was searched for IVC filter placements in children <18 years of age...
November 8, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29117143/a-smartphone-step-counter-using-imu-and-magnetometer-for-navigation-and-health-monitoring-applications
#5
Maan Khedr, Nasser El-Sheimy
The growing market of smart devices make them appealing for various applications. Motion tracking can be achieved using such devices, and is important for various applications such as navigation, search and rescue, health monitoring, and quality of life-style assessment. Step detection is a crucial task that affects the accuracy and quality of such applications. In this paper, a new step detection technique is proposed, which can be used for step counting and activity monitoring for health applications as well as part of a Pedestrian Dead Reckoning (PDR) system...
November 8, 2017: Sensors
https://www.readbyqxmd.com/read/29117014/what-s-new-in-pediatric-upper-extremity-sports-injuries
#6
Jennifer J Beck, Connor G Richmond, Marc A Tompkins, Ann Heyer, Kevin G Shea, Aristides I Cruz
BACKGROUND: Sports injuries are common in pediatric and adolescent patients and the evaluation and treatment of these injuries continues to evolve. The purpose of this review is to provide a comprehensive appraisal of the most recent literature, highlighting updates on sports-related upper extremity injuries in pediatric patients. METHODS: An electronic search of the PubMed, EMBASE, and Google Scholar databases was performed for keywords related to pediatric overhead athletes, osteochondritis dissecans (OCD) of the capitellum, medial epicondyle fractures, shoulder instability, and clavicle fractures...
November 7, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29116615/immunity-to-attentional-capture-at-ignored-locations
#7
Eric Ruthruff, Nicholas Gaspelin
Certain stimuli have the power to rapidly and involuntarily capture spatial attention against our will. The present study investigated whether such stimuli capture spatial attention even when they appear in ignored regions of visual space. In other words, which force is more powerful: attentional capture or spatial filtering? Participants performed a spatial cuing task, searching for a letter target defined by color (e.g., green) and then reporting that letter's identity. Two of the four search locations were always irrelevant...
November 7, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29112546/european-guidelines-on-perioperative-venous-thromboembolism-prophylaxis-surgery-in-the-obese-patient
#8
Linas Venclauskas, Almantas Maleckas, Juan I Arcelus
: A systematic literature search was performed and patients were selected as obese patients undergoing bariatric surgery or obese patients undergoing nonbariatric surgical procedures. In addition, patients were stratified according to low risk of venous thromboembolism and high risk of venous thromboembolism (age >55 years, BMI >55 kg m, history of venous thromboembolism, venous disease, sleep apnoea, hypercoagulability or pulmonary hypertension). Prophylaxis of venous thromboembolism was analysed depending on the type of modality: compression devices of the lower extremities (including intermittent pneumatic compression and graduated compression stockings), pharmacological prophylaxis or inferior vena cava filters...
November 6, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/29106641/the-mar-databases-development-and-implementation-of-databases-specific-for-marine-metagenomics
#9
Terje Klemetsen, Inge A Raknes, Juan Fu, Alexander Agafonov, Sudhagar V Balasundaram, Giacomo Tartari, Espen Robertsen, Nils P Willassen
We introduce the marine databases; MarRef, MarDBand MarCat (https://mmp.sfb.uit.no/databases/), which are publicly available resources that promote marine research and innovation. These data resources, which have been implemented in the Marine Metagenomics Portal (MMP) (https://mmp.sfb.uit.no/), are collections of richly annotated and manually curated contextual (metadata) and sequence databases representing three tiers of accuracy. While MarRef is a database for completely sequenced marine prokaryotic genomes, which represent a marine prokaryote reference genome database, MarDB includes all incomplete sequenced prokaryotic genomes regardless level of completeness...
November 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29106455/virapipe-scalable-parallel-pipeline-for-viral-metagenome-analysis-from-next-generation-sequencing-reads
#10
Altti Ilari Maarala, Zurab Bzhalava, Joakim Dillner, Keijo Heljanko, Davit Bzhalava
Motivation: Next Generation Sequencing (NGS) technology enables identification of microbial genomes from massive amount of human microbiomes more rapidly and cheaper than ever before. However, the traditional sequential genome analysis algorithms, tools, and platforms are inefficient for performing large-scale metagenomic studies on ever-growing sample data volumes. Currently, there is an urgent need for scalable analysis pipelines that enable harnessing all the power of parallel computation in computing clusters and in cloud computing environments...
November 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29099922/draft-genome-of-the-reindeer-rangifer-tarandus
#11
Zhipeng Li, Zeshan Lin, Hengxing Ba, Lei Chen, Yongzhi Yang, Kun Wang, Qiu Qiang, Wen Wang, Guangyu Li
Background: Reindeer (Rangifer tarandus) is the only fully domesticated species in the Cervidae family, and is the only cervid with a circumpolar distribution. Unlike all other cervids, female reindeer regularly grow cranial appendages (antlers, the defining characteristics of cervids), as well as males. Moreover, reindeer milk contains more protein and less lactose than bovids' milk. A high quality reference genome of this species will assist efforts to elucidate these and other important features in the reindeer...
November 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29098829/-difference-of-chemical-constituents-in-eucommiae-cortex-from-different-habitats-by-lc-qtof-ms-ms
#12
Ying Yan, Hui Zhao, Li-Si Zou, Xun-Hong Liu, Chuan Chai, Sheng-Nan Wang, Yu-Jiao Hua
In order to study the influence of ecological environment regarding the synthesis and accumulation of metabolites in Eucommiae Cortex, LC-QTOF MS/MS method combined with multivariate statistical analysis was used to analyze the differences of chemical constituents in Eucommiae Cortex from different habitats. Through the analysis of the multistage tandem mass spectrometry, the characteristic peaks were extracted with mass spectrometry data peak matching, peak alignment, and noise filtering. Principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) were used for data processing...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29096874/altering-spatial-priority-maps-via-statistical-learning-of-target-selection-and-distractor-filtering
#13
Oscar Ferrante, Alessia Patacca, Valeria Di Caro, Chiara Della Libera, Elisa Santandrea, Leonardo Chelazzi
The cognitive system has the capacity to learn and make use of environmental regularities - known as statistical learning (SL), including for the implicit guidance of attention. For instance, it is known that attentional selection is biased according to the spatial probability of targets; similarly, changes in distractor filtering can be triggered by the unequal spatial distribution of distractors. Open questions remain regarding the cognitive/neuronal mechanisms underlying SL of target selection and distractor filtering...
October 9, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29096382/a-novel-approach-for-dimension-reduction-of-microarray
#14
Rabia Aziz, C K Verma, Namita Srivastava
This paper proposes a new hybrid search technique for feature (gene) selection (FS) using Independent component analysis (ICA) and Artificial Bee Colony (ABC) called ICA+ABC, to select informative genes based on a Naïve Bayes (NB) algorithm. An important trait of this technique is the optimization of ICA feature vector using ABC. ICA+ABC is a hybrid search algorithm that combines the benefits of extraction approach, to reduce the size of data and wrapper approach, to optimize the reduced feature vectors. This hybrid search technique is facilitated by evaluating the performance of ICA+ABC on six standard gene expression datasets of classification...
October 28, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29095940/expressiondb-an-open-source-platform-for-distributing-genome-scale-datasets
#15
Laura D Hughes, Scott A Lewis, Michael E Hughes
RNA-sequencing (RNA-seq) and microarrays are methods for measuring gene expression across the entire transcriptome. Recent advances have made these techniques practical and affordable for essentially any laboratory with experience in molecular biology. A variety of computational methods have been developed to decrease the amount of bioinformatics expertise necessary to analyze these data. Nevertheless, many barriers persist which discourage new labs from using functional genomics approaches. Since high-quality gene expression studies have enduring value as resources to the entire research community, it is of particular importance that small labs have the capacity to share their analyzed datasets with the research community...
2017: PloS One
https://www.readbyqxmd.com/read/29092202/simpplified-extended-kalman-filter-phase-noise-estimation-for-co-ofdm-transmissions
#16
Tu T Nguyen, Son T Le, Marc Wuilpart, Tatiana Yakusheva, Patrice Mégret
We propose a flexible simplified extended Kalman filter (S-EKF) scheme that can be applied in both pilot-aided and blind modes for phase noise compensation in 16-QAM CO-OFDM transmission systems employing a small-to-moderate number of subcarriers. The performance of the proposed algorithm is evaluated and compared with conventional pilot-aided (PA) and blind phase search (BPS) methods via extensive an Monte Carlo simulation in a back-to-back configuration and with a dual polarization fiber transmission. For 64 subcarrier 32 Gbaud 16-QAM CO-OFDM systems with 200 kHz combined laser linewidths, an optical signal-to-noise ratio penalty as low as 1 dB can be achieved with the proposed S-EKF scheme using only 2 pilots in the pilot-aided mode and just 4 inputs in the blind mode, resulting in a spectrally efficient enhancement by a factor of 3 and a computational effort reduction by a factor of more than 50 in comparison with the conventional PA and the BPS methods, respectively...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29081410/whole-exome-sequencing-to-identify-novel-mutations-of-nevoid-basal-cell-carcinoma-syndrome-in-a-chinese-population
#17
Nanhang Lu, Jinzeng Wang, Bijun Zhu, Miaomiao Zhang, Fazhi Qi, Xiangdong Wang, Jianying Gu
BACKGROUND: Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease with a complex genetic etiology. Although three causative genes (PTCH1, PTCH2, SUFU) have been identified through linkage analysis and Sanger sequencing, the genetic background of NBCCS hasn't been fully understood. METHODS: We performed a whole-exome sequencing (WES) in a Han Chinese NBCCS family and two unaffected volunteers to search for its causative gene. Bioinformatic analysis was used to select candidate genes and analyze the functional networks of each candidate gene...
October 20, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29077859/panx-pan-genome-analysis-and-exploration
#18
Wei Ding, Franz Baumdicker, Richard A Neher
Horizontal transfer, gene loss, and duplication result in dynamic bacterial genomes shaped by a complex mixture of different modes of evolution. Closely related strains can differ in the presence or absence of many genes, and the total number of distinct genes found in a set of related isolates-the pan-genome-is often many times larger than the genome of individual isolates. We have developed a pipeline that efficiently identifies orthologous gene clusters in the pan-genome. This pipeline is coupled to a powerful yet easy-to-use web-based visualization for interactive exploration of the pan-genome...
October 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29065947/taking-patient-heterogeneity-and-preferences-into-account-in-health-technology-assessments
#19
Wietske Kievit, Marcia Tummers, Ralph van Hoorn, Andrew Booth, Kati Mozygemba, Pietro Refolo, Dario Sacchini, Lisa Pfadenhauer, Ansgar Gerhardus, Gert Jan Van der Wilt
OBJECTIVES: The INTEGRATE-HTA project provided methodology to evaluate complex technologies. This study provides guidance on how to retrieve and critically appraise available evidence on moderators and predictors of treatment effects and on patient preferences for treatment outcomes as a source of complexity. METHODS: Search filters for PubMed were developed by hand-searching a large volume of articles reporting on relevant aspects. Search terms were retrieved from selected papers and algorithmically combined to find the optimal combination of search terms...
October 25, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29065942/performance-of-ovid-medline-search-filters-to-identify-health-state-utility-studies
#20
Mick Arber, Sonia Garcia, Thomas Veale, Mary Edwards, Alison Shaw, Julie M Glanville
OBJECTIVES: This study was designed to assess the sensitivity of three Ovid MEDLINE search filters developed to identify studies reporting health state utility values (HSUVs), to improve the performance of the best performing filter, and to validate resulting search filters. METHODS: Three quasi-gold standard sets (QGS1, QGS2, QGS3) of relevant studies were harvested from reviews of studies reporting HSUVs. The performance of three initial filters was assessed by measuring their relative recall of studies in QGS1...
October 25, 2017: International Journal of Technology Assessment in Health Care
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