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https://www.readbyqxmd.com/read/29668129/-tuberculosis-in-the-era-of-anti-tnf-alpha-therapy-why-does-the-risk-still-exist
#1
John-Leonardo Torres-Castiblanco, Jorge Alberto Carrillo, Daniel Hincapié-Urrego, Adriana Rojas-Villarraga
Rheumatoid arthritis is an autoimmune systemic disease characterized mainly by inflammatory compromise of diarthrodial joints. Multiple drug therapies have been developed to control the activity of rheumatoid arthritis, among them, the first line of disease-modifying antirheumatic drugs (DMARD), and novel drug therapies such as the anti-TNF alpha therapy, with satisfactory clinical outcomes.Despite this positive fact, the use of this therapy implies the risk of producing negative effects due to its mechanism of action, which has been associated with multiple infections, especially tuberculosis, making it necessary to use screen tests before resorting to this kind of drugs...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29668128/tuberculosis-associated-with-tumor-necrosis-factor-%C3%AE-antagonists-case-description-and-analysis-of-reported-cases-in-colombia
#2
Leandro Galvis, Ángel Y Sánchez, Leonardo F Jurado, Martha I Murcia
Tumor necrosis factor-α (TNF-α) is an important fundamental cytokine during the immune response against cancer and infections such as tuberculosis. This molecule also plays a key pathogenic role in complex and difficult-to-treat diseases such as rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, psoriasis and ulcerative colitis. The treatment of these diseases frequently needs TNF-α antagonists, which has been related to an increased risk of developing tuberculosis, mycoses, and other severe infections...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667146/cost-effectiveness-analysis-of-crohn-s-disease-treatment-with-vedolizumab-and-ustekinumab-after-failure-of-tumor-necrosis-factor-%C3%AE-antagonist
#3
Przemysław Holko, Paweł Kawalec, Andrzej Pilc
OBJECTIVE: The aim was to evaluate the cost-effectiveness of Crohn's disease (CD) treatment with vedolizumab and ustekinumab after failure of therapy with tumor necrosis factor-α antagonists (anti-TNFs). METHODS: The Markov model incorporated the lifetime horizon, synthesis-based estimates of biologics' efficacy in relation to anti-TNF exposure, and administration of biologics reflecting clinical practice (e.g., sequence of biologics, retreatment, 12-month treatment)...
April 17, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29666076/histoplasma-meets-crohn-s-disease-a-rare-case-of-new-onset-ascites
#4
Charles Robert Bosshardt, John Gnann, Nilesh Lodhia
A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665498/glabridin-an-isoflavan-from-licorice-root-ameliorates-imiquimod-induced-psoriasis-like-inflammation-of-balb-c-mice
#5
Penghui Li, Yonglian Li, Hong Jiang, Yuting Xu, Xiaoying Liu, Biao Che, Jian Tang, Guangrong Liu, Yadong Tang, Wei Zhou, Langyue Zhang, Changzhi Dong, Huixiong Chen, Kun Zhang, Zhiyun Du
In this paper, we investigate the effect of glabridin (Glab) on psoriasis. We observed that Glab significantly suppressed the levels of nitric oxide (NO), NF-κB subunit p65, interleukin (IL)-6, and IL-1β in lipopolysaccharide (LPS)-stimulated HaCaT cells. In addition, Glab treatment reduced the expression of IL-17A, IL-22, and IL-23 in TNF-α-stimulated-HaCaT cells. These findings prompted us to test whether Glab could be used to treat psoriasis in vivo. The effects of Glab on PASI scores, histopathological changes, oxidative/anti-oxidative indexes and pro-inflammatory cytokines in IMQ-induced mice were investigated...
April 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29663878/role-of-angiogenenic-growth-factors-in-psoriasis-a-review
#6
Tahseena Akhtar, Willayat Yousuf Wani, Mohammad A Kamal, Rajinder Kaur
BACKGROUND: Psoriasis is a chronic inflammatory disease, involving autoimmune mechanism wherein immune system, autoantigens and various environmental triggers all interact to create the systemically diseased state. It is a multifactorial skin disease of complex nature characterized by infiltration of multiple immune cells, kerationcyte proliferation, and increased dermal vascularity. Among all factors, vascular alterations present a significant feature of the disease and angiogenesis seems to have an important role in giving rise to psoriasis phenotype...
April 16, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29663266/hepatitis-b-virus-screening-and-reactivation-in-a-national-va-cohort-of-patients-with-inflammatory-bowel-disease-treated-with-tumor-necrosis-factor-antagonists
#7
Rajesh Shah, Edith Y Ho, Jennifer R Kramer, Peter Richardson, Shubhada Sansgiry, Hashem B El-Serag, Jason K Hou
BACKGROUND: Practice guidelines recommend screening for hepatitis B virus (HBV) infection prior to initiating treatment of inflammatory bowel disease (IBD) with anti-tumor necrosis factor (anti-TNF) therapy. However, the adherence to these screening guidelines and the clinical outcomes of HBV reactivation following anti-TNF use are not well known. METHODS: This is a retrospective cohort study using the Veterans Health Administration datasets for IBD patients with filled prescriptions for anti-TNFs from 2003 to 2011...
April 16, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29662549/tumour-necrosis-factor-interferon-gamma-and-interleukins-as-predictive-markers-of-antiprogrammed-cell-death-protein-1-treatment-in-advanced-non-small-cell-lung-cancer-a-pragmatic-approach-in-clinical-practice
#8
Efimia Boutsikou, Kalliopi Domvri, Georgia Hardavella, Dora Tsiouda, Konstantinos Zarogoulidis, Theodoros Kontakiotis
Background: The emergence of novel antiprogrammed cell death protein-1 (PD-1) inhibitors in non-small cell lung cancers (NSCLC) has revolutionized the therapeutic landscape of this disease. Although overall survival (OS) has improved in the first- and second-line therapy settings for advanced NSCLC, the benefit is not universal. In a climate of global scrutiny for healthcare costs and potential for toxicities related to immunotherapy, appropriate patient selection is crucial. The aim of this study was to evaluate potential prognostic and predictive biomarkers interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and a panel of interleukins (ILs) in the peripheral blood, and assess any correlation with response to anti-PD-1 inhibition, progression-free survival and OS in NSCLC patients...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29662489/immunological-approaches-towards-cancer-and-inflammation-a-cross-talk
#9
REVIEW
Xinglong Qu, Ying Tang, Shucheng Hua
The inflammation is the protective response of the body against various harmful stimuli; however, the aberrant and inappropriate activation tends to become harmful. The acute inflammatory response tends to resolved once the offending agent is subside but this acute response becomes chronic in nature when the body is unable to successfully neutralized the noxious stimuli. This chronic inflammatory microenvironment is associated with the release of various pro-inflammatory and oncogenic mediators such as nitric oxide (NO), cytokines [IL-1β, IL-2, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)], growth factor, and chemokines...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661087/allylpyrocatechol-attenuates-methotrexate-induced-hepatotoxicity-in-a-collagen-induced-model-of-arthritis
#10
Soumita De, Sunanda Kundu, Uttara Chatterjee, Subrata Chattopadhyay, Mitali Chatterjee
The cornerstone of treatment for rheumatoid arthritis is low dose methotrexate (MTX), but its use is limited by concerns regarding its potential for hepatotoxicity. Allylpyrocatechol (APC), a phytoconstituent sourced from leaves of Piper betle demonstrated antioxidant, anti-inflammatory and antiarthritic properties. The present study aimed to evaluate the combined effect of APC and MTX on limiting progression of lipopolysaccharide accelerated collagen-induced arthritis, along with reduction of MTX-induced hepatic damage...
April 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29659324/montelukast-attenuates-radioactive-i131-induced-pulmonary-damage-on-rats
#11
Arif Osman Tokat, Aylin Akbulut, Deniz Billur, Gokhan Koca, Pinar Bayram, Serdar Kuru, Sezgin Karasu, Suheyla Aydogmus, Hüseyin Cakmak, Sengul Ozmert, Meliha Korkmaz
PURPOSE: Radioactive I131 (RAI) therapy is a standard method to ablate the remnant thyroidal tissue after total thyroidectomy and its metastases in differentiated thyroid carcinomas, however, I131 also accumulates in non-thyroidal tissue, which may cause adverse effects and limit the I131 dose required for treatment. We hypothesized that montelukast, a known agent with anti-inflammatory and anti-oxidant properties, would ameliorate the radiation-induced histopathological characteristics such as pneumonitis and fibrosis in rat lungs after RAI...
April 16, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29658573/hedgehog-signaling-regulates-the-expression-levels-of-inflammatory-mediators-in-cigarette%C3%A2-induced-airway-inflammation
#12
Yi Guo, Guochao Shi, Huanying Wan, Min Zhou
Chronic obstructive pulmonary disease (COPD) is a persistent airway inflammation influenced by cigarette smoke. Previous studies have reported that Hedgehog (Hh) signaling is aberrantly activated by cigarette smoke and dysregulated in COPD. The present study explored the role of the Hh signaling pathway on the expression levels of certain inflammatory mediators in cigarette‑induced airway inflammation. Herein, a total of three A549 cell populations were generated: The A0 group as control cells, the A1 group cells treated with nicotine at a concentration of 10 µM for 12, 24 and 48 h, and the A2 group cultured simultaneously with nicotine and cyclopamine for the same duration...
April 11, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29657867/the-relationship-of-serum-endocan-levels-and-anti-tnf-alpha-therapy-in-patients-with-ankylosing-spondylitis
#13
Fatma Zehra Kadayıfçı, Makbule Gezmen Karadağ
Objective: Endocan is a marker for vascular pathogenesis and important mediator of angiogenesis that strongly associates with inflammation and vascular diseases. Growing evidence suggest that inflammatory cytokine tumor necrosis factor (TNF-alpha) plays a role in its regulation and secretion, whereas TNF-alpha inhibitors may have the opposite influence. The aim of this research is to investigate the association between serum endocan and anti-TNF-alpha drug treatment in patients with ankylosing spondylitis (AS)...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29656414/add-on-memantine-treatment-for-bipolar-ii-disorder-comorbid-with-alcohol-dependence-a-12-week-follow-up-study
#14
Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
BACKGROUND: Bipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproate (VPA) treatment ameliorated clinical symptoms, reduced alcohol use and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29655972/effectiveness-and-safety-of-anti-tnf-therapy-for-inflammatory-bowel-disease-in-liver-transplant-recipients-for-primary-sclerosing-cholangitis-a-nationwide-case-series
#15
Romain Altwegg, Roman Combes, David Laharie, Victor De Ledinghen, Sylvie Radenne, Filomena Conti, Olivier Chazouilleres, Christophe Duvoux, Jérôme Dumortier, Vincent Leroy, Xavier Treton, François Durand, Sébastien Dharancy, Maria Nachury, Félix Goutorbe, Géraldine Lamblin, Lucile Boivineau, Laurent Peyrin-Biroulet, Georges-Philippe Pageaux
BACKGROUND: There is a lack of consensus regarding the treatment of inflammatory bowel disease (IBD) after liver transplantation (LT) forprimary sclerosing cholangitis (PSC). AIM: To investigate the safety and effectiveness of anti-TNF therapy in patients with IBD after a LT for PSC. METHODS: We reviewed the medical files of all of the IBD patients who underwent a LT for PSC and who were treated with anti-TNF therapy at 23 French liver transplantation centers between 1989 and 2012...
March 13, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29655835/risk-of-serious-and-opportunistic-infections-associated-with-treatment-of-inflammatory-bowel-diseases
#16
Julien Kirchgesner, Magali Lemaitre, Fabrice Carrat, Mahmoud Zureik, Md Franck Carbonnel, Rosemary Dray-Spira
BACKGROUND & AIMS: The risk of infection associated with tumor necrosis factor antagonists (anti-TNF) and thiopurines (combination therapy) is uncertain. We assessed the risk of serious and opportunistic infections in patients with IBD treated with thiopurine monotherapy, anti-TNF monotherapy, or combination therapy in a large cohort of patients in France. METHODS: We performed a nationwide population-based study of patients (18 years or older) with a diagnosis of IBD in the French national health insurance database; we collected data from January 1, 2009 until December 31, 2014...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29651017/effects-of-different-doses-of-granulocyte-colony-stimulating-factor-mobilization-therapy-on-ischemic-cardiomyopathy
#17
Rongchong Huang, Haichen Lv, Kang Yao, Lei Ge, Zhishuai Ye, Huaiyu Ding, Yiqi Zhang, Hao Lu, Zheyong Huang, Shuning Zhang, Yunzeng Zou, Junbo Ge
G-CSF mobilization might be beneficial to ICM, but the relationship between effect/safety and the dosage of G-CSF remains unclear. In this study, 24 pigs were used to build ICM models and were randomized into four groups. Four weeks later, different dosages of G-CSF were given daily by subcutaneous injection for 5 days. Another 4 weeks later, all the animals were sacrificed. Electrocardiography, coronary arteriography, left ventriculography, transthoracic echocardiography, cardiac MRI, and SPECT, histopathologic analysis, and immunohistochemistry techniques were used to evaluate left ventricular function and myocardial infarct size...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650491/fecal-microbiota-composition-drives-immune-activation-in-hiv-infected-individuals
#18
Charles Preston Neff, Owen Krueger, Kathy Xiong, Sabrina Arif, Nichole Nusbacher, Jennifer M Schneider, Annie W Cunningham, Abigail Armstrong, Sam Li, Martin D McCarter, Thomas B Campbell, Catherine A Lozupone, Brent E Palmer
The inflammatory properties of the enteric microbiota of Human Immunodeficiency Virus (HIV)-infected individuals are of considerable interest because of strong evidence that bacterial translocation contributes to chronic immune activation and disease progression. Altered enteric microbiota composition occurs with HIV infection but whether altered microbiota composition or increased intestinal permeability alone drives peripheral immune activation is controversial. To comprehensively assess the inflammatory properties of HIV-associated enteric microbiota and relate these to systemic immune activation, we developed methods to purify whole fecal bacterial communities (FBCs) from stool for use in in vitro immune stimulation assays with human cells...
March 26, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29649840/-therapeutic-concepts-for-treatment-of-patients-with-non-infectious-uveitis-biologic-disease-modifying-antirheumatic-drugs
#19
Karoline Walscheid, Uwe Pleyer, Arnd Heiligenhaus
Biologic disease modifying antirheumatic drugs (bDMARDs) can be highly efficient in the treatment of various non-infectious uveitis entities. Currently, the TNF-α-inhibitor Adalimumab is the only in-label therapeutic option, whereas, all other bDMARDs need to be given as an off-label therapy. bDMARDs are indicated in diseases refractory to conventional synthetic DMARD therapy and/or systemic steroids, or in patients in whom treatment with those is not possible due to side effects. Therapeutic mechanisms currently employed are cytokine-specific (interferons, inhibition of TNF-α or of interleukin [IL]-1-, IL-6- or IL-17-signalling), inhibit T cell costimulation (CTLA-4 fusion protein), or act via depletion of B cells (anti-CD20)...
April 12, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29648839/a-novel-immunoliposome-technology-for-enhancing-the-activity-of-agonistic-antibody-against-tumor-necrosis-factor-receptor-superfamily
#20
Takako Niwa, Yuji Kasuya, Yukie Suzuki, Kimihisa Ichikawa, Hiroko Yoshida, Akiko Kurimoto, Kento Tanaka, Koji Morita
We have developed a technology for efficiently enhancing the anti-cancer apoptosis-inducing activity of agonistic antibodies against the tumor necrosis factor receptor (TNFR) superfamily by the formation of immunoliposomes. To induce apoptosis in cancer cells, agonistic antibodies to the TNFR superfamily normally need cross-linking by internal immune effector cells via the Fc region after binding to receptors on the cell membrane. To develop apoptosis-inducing antibodies that do not require the support of cross-linking by immune cells, we prepared immunoliposomes conjugated with TRA-8, an agonistic antibody against death receptor 5 (DR5), with various densities of antibody on the liposome surface, and evaluated their activities...
April 12, 2018: Molecular Pharmaceutics
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