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https://www.readbyqxmd.com/read/28211343/immediate-reactions-to-more-than-1-nsaid-must-not-be-considered-cross-hypersensitivity-unless-tolerance-to-asa-is-verified
#1
D Pérez-Alzate, J A Cornejo-García, N Pérez-Sánchez, I Andreu, A García-Moral, J A Agúndez, J Bartra, I Doña, M J Torres, M Blanca, N Blanca-López, G Canto
BACKGROUND AND OBJECTIVES: Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents a reaction after intake of or challenge with acetylsalicylic acid (ASA). Whether patients react to 2 or more NSAIDs while tolerating ASA remains to be studied (selective reactions, SRs). Objective: To identify patients with SRs to 2 or more NSAIDs including strong COX-1 inhibitors...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28207522/prisma-combined-%C3%AE-blockers-and-antimuscarinics-for-ureteral-stent-related-symptoms-a-meta-analysis
#2
Yu-Ming Zhang, Pei Chu, Wen-Jin Wang
BACKGROUND: As a monotherpay, a-blockers and anti-muscarinics are both efficacy for ureteral stent-related symptoms (SRS). The aim of the study was to systematically evaluate their efficacy of a combination therapy for SRS. METHODS: Relevant studies investigating α-blockers and/or anti-muscarinics for SRS were identified though searching online databases including PubMed, EMBASE, Cochrane Library, and other sources up to March 2016. The RevMan software was used for data analysis, and senesitivity analysis and inverted funnel plot were also adopted...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28199771/thyroid-dysfunction-in-children-with-autism-spectrum-disorder-is-associated-with-folate-receptor-alpha-autoimmune-disorder
#3
Richard E Frye, Rebecca Wynne, Shannon Rose, John Slattery, Leanna Delhey, Marie Tippett, Stephen G Kahler, Sirish C Bennuri, Stepan Melnyk, Jeffrey M Sequeira, Edward Quadros
Folate receptor α (FRα) autoantibodies (FRAAs) are prevalent in Autism Spectrum Disorder (ASD). FRAAs disrupt folate transport across the blood-brain barrier by binding to the FRα. Thyroid dysfunction is frequently found in children with ASD. We measured blocking and binding FRAAs and thyroid stimulating hormone (TSH), free T4 (FT4), total T3 (TT3), reverse T3 (rT3), thyroid releasing hormone (TRH) and other metabolites in 87 children with ASD, 84 of whom also underwent behavior and cognition testing and in 42 of whom FRAAs, TSH and FT4 were measured at two time points...
February 15, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28198892/stimulated-raman-scattering-microscopy-and-spectroscopy-with-a-rapid-scanning-optical-delay-line
#4
Ruoyu He, Zhiping Liu, Yongkui Xu, Wei Huang, Hong Ma, Minbiao Ji
Stimulated Raman scattering (SRS) microscopy that is capable of both high-speed imaging and rapid spectroscopy will be advantageous for detailed chemical analysis of heterogeneous biological specimens. We have developed a system based on spectral focusing SRS technology with the integration of a rapid scanning optical delay line, which allows continuous tuning of SRS spectra by scanning a galvo mirror. We demonstrate SRS spectral measurements of dimethyl sulfoxide solution at low concentrations and multi-color imaging of rice pollens and HeLa cells with line-by-line delay tuning to reduce motion artifacts, as well as fast acquisition of SRS spectra at specific regions of interest...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28196399/relationship-of-the-recurrent-laryngeal-nerve-to-the-inferior-thyroid-artery-a-comparison-of-findings-from-two-systematic-reviews
#5
REVIEW
Anthony P Polednak
Systematic reviews (SRs) of anatomical studies may include a meta-analysis (MA) that provides weighted averages as pooled estimates of prevalence. The relationship of the recurrent laryngeal nerve (RLN) to the inferior thyroid artery (ITA) or its branches has been assessed in two published SRs, one without MA of 32 studies (SR1) and the other with MA of 79 studies (SR2). Both SRs reported differences in RLN-ITA patterns (in three categories) by side of the body, but the anterior pattern was less frequent in SR1 vs...
February 14, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28195750/dosimetric-analysis-of-neural-and-vascular-structures-in-skull-base-tumors-treated-with-stereotactic-radiosurgery
#6
Yarah M Haidar, Jay M Bhatt, Yaser Ghavami, Omid Moshtaghi, Amanda Schwer, Stafford Chenery, Hamid R Djalilian
Objective To examine the relationship between the prescribed target dose and the dose to healthy neurovascular structures in patients with vestibular schwannomas treated with stereotactic radiosurgery (SRS). Study Design Case series with chart review. Setting SRS center from 2011 to 2013. Subjects Twenty patients with vestibular schwannomas treated at the center from 2011 to 2013. Methods Twenty patients with vestibular schwannomas were included. The average radiation dose delivered to healthy neurovascular structures (eg, carotid artery, basilar artery, facial nerve, trigeminal nerve, and cochlea) was analyzed...
February 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28193137/risk-factors-for-adjacent-segment-degeneration-after-iliac-screw-fixation-in-lumbar-degenerative-kyphoscoliosis
#7
Sang-Il Kim, Kee-Yong Ha, Dong-Whan Suh, In-Soo Oh
PURPOSE: To analyze pre- and postoperative spinopelvic parameters and sagittal profiles in lumbar degenerative kyphoscoliosis (LDK) patients who underwent surgery using iliac screw (IS) and the incidence and risk factor of radiological adjacent segment degeneration (ASD). METHODS: A total of 32 patients, who had undergone surgical correction and lumbar/thoracolumbar fusion with pedicle screws and IS instrumentation for LDK with a minimum 2-year follow-up, were included...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28192600/systematic-reviews-and-meta-analyses-on-psoriasis-role-of-funding-sources-conflict-of-interest-and-bibliometric-indices-as-predictors-of-methodological-quality
#8
F Gómez-García, J Ruano, M Aguilar-Luque, J Gay-Mimbrera, B Maestre-Lopez, J L Sanz-Cabanillas, P J Carmona-Fernández, M González-Padilla, A Vélez García-Nieto, B Isla-Tejera
BACKGROUND: The quality of systematic reviews (SRs) and meta-analyses about psoriasis, a chronic inflammatory skin disease that severely impairs quality of life and is associated with high costs, remains unknown. OBJECTIVES: To assess the methodological quality of SRs published on psoriasis. METHODS: After a comprehensive search in MEDLINE, EMBASE, and the Cochrane Database (PROSPERO:CDR4201604161), the quality was assessed by two raters using Assessment of Multiple Systematic Reviews (AMSTAR) tool...
February 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28186473/minimally-invasive-scoliosis-surgery-assisted-by-o-arm-navigation-for-lenke-type-5c-adolescent-idiopathic-scoliosis-a-comparison-with-standard-open-approach-spinal-instrumentation
#9
Weiguo Zhu, Weixiang Sun, Leilei Xu, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu
OBJECTIVE Recently, minimally invasive scoliosis surgery (MISS) was introduced for the correction of adult scoliosis. Multiple benefits including a good deformity correction rate and fewer complications have been demonstrated. However, few studies have reported on the use of MISS for the management of adolescent idiopathic scoliosis (AIS). The purpose of this study was to investigate the outcome of posterior MISS assisted by O-arm navigation for the correction of Lenke Type 5C AIS. METHODS The authors searched a database for all patients with AIS who had been treated with either MISS or PSF between November 2012 and January 2014...
February 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28181411/infant-muscle-tone-and-childhood-autistic-traits-a-longitudinal-study-in-the-general-population
#10
Fadila Serdarevic, Akhgar Ghassabian, Tamara van Batenburg-Eddes, Tonya White, Laura M E Blanken, Vincent W V Jaddoe, Frank C Verhulst, Henning Tiemeier
In a longitudinal population-based study of 2,905 children, we investigated if infants' neuromotor development was associated with autistic traits in childhood. Overall motor development and muscle tone were examined by trained research assistants with an adapted version of Touwen's Neurodevelopmental Examination between ages 2 and 5 months. Tone was assessed in several positions and items were scored as normal, low, or high tone. Parents rated their children's autistic traits with the Social Responsiveness Scale (SRS) and the Pervasive Developmental Problems (PDP) subscale of the Child Behavior Checklist at 6 years...
February 9, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28180979/the-influence-of-isolated-thoracoplasty-on-the-evolution-of-pulmonary-function-after-treatment-of-severe-thoracic-scoliosis
#11
Heiko Koller, Tobias L Schulte, Oliver Meier, Juliane Koller, Viola Bullmann, Wolfgang Hitzl, Michael Mayer, Tobias Lange, Jens Schmücker
INTRODUCTION AND PURPOSE: Isolated thoracoplasty (iTP) on the convex side is performed long time after scoliosis surgery has been performed. ITP is thought to cause a further decline in pulmonary function (PF); however, the amount of decline is ill defined. The objectives of this study were to examine the influence of iTP on the postoperative evolution of PF and rib hump reduction in patients that previously undergone scoliosis surgery. METHODS: Over an 11-year period, 75 patients underwent iTP...
February 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28179176/peri-srs-administration-of-immune-checkpoint-therapy-for-melanoma-metastatic-to-the-brain-investigating-efficacy-and-the-effects-of-relative-treatment-timing-on-lesion-response
#12
Mehran B Yusuf, Mark J Amsbaugh, Eric Burton, Jason Chesney, Shiao Woo
OBJECTIVE(S): To investigate the efficacy of immune checkpoint therapy (ICT) administered with stereotactic radiosurgery (SRS) and determine the effects of relative treatment timing on lesion response. METHODS: A prospective institutional database of all patients with intact brain metastases treated with SRS from 2007 to 2015 was reviewed for patients diagnosed with malignant melanoma. Lesion response was determined using a modified RECIST v1.1 criteria. Patients were grouped according to if they received ICT and the timing of ICT relative to SRS...
February 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28178376/treatment-trends-for-patients-with-brain-metastases-does-practice-reflect-the-data
#13
Kiri A Sandler, Narek Shaverdian, Ryan R Cook, Amar U Kishan, Christopher R King, Isaac Yang, Michael L Steinberg, Percy Lee
BACKGROUND: Published guidelines regarding the optimal treatment strategies for brain metastases focus on patients with ≤3 lesions. As delivery techniques for stereotactic radiosurgery (SRS) improve, radiation oncologists are increasingly using it for patients with >3 metastases. In the current study, the authors sought to characterize practice patterns among practitioners to identify areas of controversy. METHODS: A survey of practicing radiation oncologists was distributed via e-mail...
February 8, 2017: Cancer
https://www.readbyqxmd.com/read/28175505/343%C3%A2-results-of-the-2015-srs-survey-on-single-versus-two-attending-surgeon-approach-for-adult-spinal-deformity-surgery
#14
Justin K Scheer, Lloyd Hey, Michael LaGrone, Michael Daubs, Christopher P Ames
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28174224/endorsement-of-prisma-statement-and-quality-of-systematic-reviews-and-meta-analyses-published-in-nursing-journals-a-cross-sectional-study
#15
Wilson W S Tam, Kenneth K H Lo, Parames Khalechelvam
OBJECTIVE: Systematic reviews (SRs) often poorly report key information, thereby diminishing their usefulness. Previous studies evaluated published SRs and determined that they failed to meet explicit criteria or characteristics. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was recommended as a reporting guideline for SR and meta-analysis (MA), but previous studies showed that adherence to the statement was not high for SRs published in different medical fields...
February 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28169234/salvage-stereotactic-radiosurgery-for-recurrent-glioblastoma-multiforme-with-prior-radiation-therapy
#16
Douglas E Holt, Mark E Bernard, Kimmen Quan, David A Clump, Johnathan A Engh, Steven A Burton, Dwight E Heron
BACKGROUND: Glioblastoma multiforme (GBM) carries a poor prognosis with high recurrence rates. Salvage stereotactic radiosurgery (SRS) may be an effective treatment option. METHODS: We retrospectively reviewed 34 patients (41 lesions) treated with salvage SRS for recurrent GBM between 2004 and 2012. Initial surgical treatments were gross total resection (58%), subtotal resection (STR) (24%), and biopsy (18%). All patients were treated with prior radiation therapy...
October 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28168125/role-of-gamma-knife%C3%A2-radiosurgery-for-the-treatment-of-brain-metastases-from-gynecological-cancers
#17
Andrew Keller, Rahim Ismail, Peter S Potrebko, Julie Pepe, Meiling Wu, Kunal Saigal, Matthew Biagioli, Ravi Shridhar, Robert Holloway, Melvin Field, Nikhil G Rao
OBJECTIVE: Gamma Knife(®) (GK) (Elekta Instruments, Stockholm, Sweden) radiosurgery is well established for treatment of brain metastases. There are limited data on patients treated with GK from gynecological cancers. The authors sought to determine the effectiveness of the GK in patients with brain metastases from gynecological cancers. METHODS: An IRB-approved database was queried for patients with gynecologic cancers treated with GK between June 1996 and May 2016...
December 31, 2016: Curēus
https://www.readbyqxmd.com/read/28166747/investigating-the-validation-of-the-chinese-mandarin-version-of-the-social-responsiveness-scale-in-a-mainland-china-child-population
#18
Chao-Qun Cen, Ya-Yong Liang, Qiu-Ru Chen, Kai-Yun Chen, Hong-Zhu Deng, Bi-Yuan Chen, Xiao-Bing Zou
BACKGROUND: Researchers from several different countries have found the Social Responsiveness Scale (SRS) to have good psychometric properties. However, to our knowledge, no studies on this subject have been reported in Mainland China. In this study, we investigated the psychometric properties of the Chinese Mandarin version of the SRS when used in Mainland China. METHODS: The reliability and validity of the parent-report SRS in a sample of 749 children of 4- to 14-year-olds: 411 typically developing and 338 clinical participants (202 with autism spectrum disorder (ASD)) were examined...
February 6, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28166388/toll-like-receptor-3-deficiency-decreases-epileptogenesis-in-a-pilocarpine-model-of-se-induced-epilepsy-in-mice
#19
Adi Gross, Felix Benninger, Ravit Madar, Tomer Illouz, Kathleen Griffioen, Israel Steiner, Daniel Offen, Eitan Okun
OBJECTIVE: Epilepsy affects 60 million people worldwide. Despite the development of antiepileptic drugs, up to 35% of patients are drug refractory with uncontrollable seizures. Toll-like receptors (TLRs) are central components of the nonspecific innate inflammatory response. Because TLR3 was recently implicated in neuronal plasticity, we hypothesized that it may contribute to the development of epilepsy after status epilepticus (SE). METHODS: To test the involvement of TLR3 in epileptogenesis, we used the pilocarpine model for SE in TLR3-deficient mice and their respective wild-type controls...
February 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28164480/real-time-raman-and-srs-imaging-of-living-human-macrophages-reveals-cell-to-cell-heterogeneity-and-dynamics-of-lipid-uptake
#20
Clara Stiebing, Tobias Meyer, Ingo Rimke, Christian Matthäus, Michael Schmitt, Stefan Lorkowski, Jürgen Popp
Monitoring living cells in real-time is important in order to unravel complex dynamic processes in life sciences. In particular the dynamics of initiation and progression of degenerative diseases is intensely studied. In atherosclerosis the thickening of arterial walls is related to high lipid levels in the blood stream, which trigger the lipid uptake and formation of droplets as neutral lipid reservoirs in macrophages in the arterial wall. Unregulated lipid uptake finally results in foam cell formation, which is a hallmark of atherosclerosis...
February 6, 2017: Journal of Biophotonics
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