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https://www.readbyqxmd.com/read/29228343/long-term-outcome-following-stereotactic-radiosurgery-for-glomus-jugulare-tumors-a-single-institution-experience-of-20-years
#1
Mayur Sharma, Antonio Meola, Sushma Bellamkonda, Xuefei Jia, Joshua Montgomery, Samuel T Chao, John H Suh, Lilyana Angelov, Gene H Barnett
BACKGROUND: Glomus jugulare tumors (GJTs) are rare benign tumors, which pose significant treatment challenges due to proximity to critical structures. OBJECTIVE: To evaluate the long-term clinical and radiological outcome in patients undergoing stereotactic radiosurgery (SRS) for GJTs through retrospective study. METHODS: Forty-two patients with 43 GJTs were treated using Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) at our institute from 1997 to 2016...
December 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29228152/effectiveness-of-nutritional-interventions-addressed-to-elderly-persons-umbrella-systematic-review-with-meta-analysis
#2
Andrea Poscia, Sonja Milovanovic, Daniele Ignazio La Milia, Mariusz Duplaga, Marcin Grysztar, Francesco Landi, Umberto Moscato, Nicola Magnavita, Agnese Collamati, Walter Ricciardi
Background: The number of Europeans aged over 65 will double between 2010 and 2060, reaching 30% of the European population. Nutrition is emerging as a key element of healthy life since both obesity and malnutrition are established risk factors for morbidity and disability. The aim of this umbrella review (UR) is to summarize the findings of all current systematic reviews (SRs) and meta-analyzes (MAs) on the effectiveness of nutritional intervention designed to promote healthy aging in older individuals...
December 8, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29228139/authorship-characteristics-of-orthodontic-randomized-controlled-trials-systematic-reviews-and-meta-analyses-in-non-orthodontic-journals-with-impact-factor
#3
Ahlam R Alqaydi, Georgios Kanavakis, Shazia Naser-Ud-Din, Athanasios E Athanasiou
Background/Objective: This study was conducted to explore authorship characteristics and publication trends of all orthodontic randomized controlled trials (RCTs), systematic reviews (SRs), and meta-analyses (MAs) published in non-orthodontic journals with impact factor (IF). Materials and methods: Appropriate research strategies were developed to search for all articles published until December 2015, without restrictions regarding language or publication status...
December 8, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29227788/posterior-only-surgical-correction-of-adolescent-idiopathic-scoliosis-an-egyptian-experience
#4
Belal Elnady, Mohammad M El-Sharkawi, Mohamed El-Meshtawy, Faisal F Adam, Galal Zaki Said
INTRODUCTION: The aim of this prospective case series study is to document safety and effectiveness of high density pedicle screws through posterior only approach with intraoperative wake-up test in correction of adolescent idiopathic scoliosis (AIS). METHODS: Between 2011 and 2015, all surgically treated patients for AIS were followed up for a minimum of 2 years. Clinical outcomes were evaluated using scoliosis research society-22 (SRS) questionnaire. All patients were classified according to Lenke classification...
2017: SICOT-J
https://www.readbyqxmd.com/read/29223987/radiosurgery-for-brain-metastases-changing-practice-patterns-and-disparities-in-the-united-states
#5
Benjamin H Kann, Henry S Park, Skyler B Johnson, Veronica L Chiang, James B Yu
Background: Management of brain metastases typically includes radiotherapy (RT) with conventional fractionation and/or stereotactic radiosurgery (SRS). However, optimal indications and practice patterns for SRS remain unclear. We sought to evaluate national practice patterns for patients with metastatic disease receiving brain RT. Methods: We queried the National Cancer Data Base (NCDB) for patients diagnosed with metastatic non-small cell lung cancer, breast cancer, colorectal cancer, or melanoma from 2004 to 2014 who received upfront brain RT...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29223973/chromosomal-rearrangements-in-the-11p15-imprinted-region-17-new-11p15-5-duplications-with-associated-phenotypes-and-putative-functional-consequences
#6
Solveig Heide, Sandra Chantot-Bastaraud, Boris Keren, Madeleine D Harbison, Salah Azzi, Sylvie Rossignol, Caroline Michot, Marilyn Lackmy-Port Lys, Bénédicte Demeer, Claudine Heinrichs, Ron S Newfield, Pierre Sarda, Lionel Van Maldergem, Véronique Trifard, Eloise Giabicani, Jean-Pierre Siffroi, Yves Le Bouc, Irène Netchine, Frédéric Brioude
BACKGROUND: The 11p15 region contains two clusters of imprinted genes. Opposite genetic and epigenetic anomalies of this region result in two distinct growth disturbance syndromes: Beckwith-Wiedemann (BWS) and Silver-Russell syndromes (SRS). Cytogenetic rearrangements within this region represent less than 3% of SRS and BWS cases. Among these, 11p15 duplications were infrequently reported and interpretation of their pathogenic effects is complex. OBJECTIVES: To report cytogenetic and methylation analyses in a cohort of patients with SRS/BWS carrying 11p15 duplications and establish genotype/phenotype correlations...
December 9, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29223524/gamma-knife-stereotactic-radiosurgery-for-non-vestibular-cranial-nerve-schwannomas
#7
Anne-Marie Langlois, Christian Iorio-Morin, Laurence Masson-Côté, David Mathieu
BACKGROUND: Non-vestibular cranial schwannomas represent a rare type of benign intracranial tumor. Few studies have evaluated the use of stereotactic radiosurgery (SRS) as a primary management option for these lesions. We therefore performed a retrospective review of our institution's experience focussing on efficacy with regards to tumor control and clinical symptom stabilization, as well as treatment safety. METHODS: Patients were included if they underwent at least one SRS procedure for a non-vestibular schwannoma and had at least 6 months of available imaging follow-up...
December 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29221028/cascaded-second-order-optical-nonlinearities-in-on-chip-micro-rings
#8
Richard Wolf, Ingo Breunig, Hans Zappe, Karsten Buse
We demonstrate cascaded Stimulated Raman Scattering (SRS), Second-Harmonic Generation (SHG), and Sum-Frequency Generation (SFG) in integrated on-chip whispering-gallery resonators (WGRs). These lithium niobate-based WGRs are fabricated using highly-parallel semiconductor manufacturing techniques coupled with specialized polishing as a post-processing step and thus represent a novel means for batch fabrication of this family of non-linear devices. We achieved record high Q-factors for on-chip lithium niobate WGRs reaching up to 3 × 106...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29218431/external-validity-of-two-nomograms-for-predicting-distant-brain-failure-after-radiosurgery-for-brain-metastases-in-a-bi-institutional-independent-patient-cohort
#9
Roshan S Prabhu, Robert H Press, Danielle M Boselli, Katherine R Miller, Scott P Lankford, Robert J McCammon, Benjamin J Moeller, John H Heinzerling, Carolina E Fasola, Kirtesh R Patel, Anthony L Asher, Ashley L Sumrall, Walter J Curran, Hui-Kuo G Shu, Stuart H Burri
Patients treated with stereotactic radiosurgery (SRS) for brain metastases (BM) are at increased risk of distant brain failure (DBF). Two nomograms have been recently published to predict individualized risk of DBF after SRS. The goal of this study was to assess the external validity of these nomograms in an independent patient cohort. The records of consecutive patients with BM treated with SRS at Levine Cancer Institute and Emory University between 2005 and 2013 were reviewed. Three validation cohorts were generated based on the specific nomogram or recursive partitioning analysis (RPA) entry criteria: Wake Forest nomogram (n = 281), Canadian nomogram (n = 282), and Canadian RPA (n = 303) validation cohorts...
December 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29218301/long-term-outcomes-after-salvage-stereotactic-radiosurgery-srs-following-in-field-failure-of-initial-srs-for-brain-metastases
#10
Nitesh Rana, Praveen Pendyala, Ryan K Cleary, Guozhen Luo, Zhiguo Zhao, Lola B Chambless, Anthony J Cmelak, Albert Attia, Mark J Stavas
Purpose: The optimal treatment strategy following local recurrence after stereotactic radiosurgery (SRS) remains unclear. While upfront SRS has been extensively studied, few reports focus on outcomes after retreatment. Here, we report the results following a second course of SRS for local recurrence of brain metastases previously treated with SRS. Methods: Using institutional database, patients who received salvage SRS (SRS2) following in-field failure of initial SRS (SRS1) for brain metastases were identified...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29215503/minimum-detectable-measurement-difference-mdmd-for-health-related-quality-of-life-hrql-measures-varies-according-age-and-disability-in-adult-spinal-deformity-asd-implications-for-calculating-minimal-clinically-important-difference-mcid
#11
Michael P Kelly, Han Jo Kim, Christopher P Ames, Douglas C Burton, Leah Yacat Carreon, David W Polly, Richard Hostin, Amit Jain, Jeffrey L Gum, Virginie Lafage, Frank J Schwab, Christopher I Shaffrey, Justin S Smith, Shay Bess
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To investigate the minimum detectable measurement difference (MDMD) in the Scoliosis Research Society-22r (SRS-22r) outcomes instrument in adult spinal deformity (ASD) and to evaluate the effect of baseline data on measurable difference. SUMMARY OF BACKGROUND DATA: The minimum clinically important difference (MCID) is the smallest, clinically relevant change observed and has been proposed for the SRS-22r instrument in ASD as 0...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29214980/ion-chambers-compliance-results-of-brazilian-radiation-therapy-facilities
#12
Georgia Santos Joana, Camila Salata, Paulo Leal, Renato Oliveira, Nozimar do Couto, Flavia Cristina Teixeira, Abner Duarte Soares, Eduardo Sergio Santini, Marcello Gomes Gonçalves
Brazilian Nuclear Energy Commission (cnen) has been making a constant effort to keep updated with international standards and national needs to strengthen the status of radiological protection of the country. The guidelines related to radiation therapy facilities have been revised in the last five years in order to take in consideration the most relevant aspects of the growing technology as well as to mitigate the accidents or incidents observed in practice. Hence, clinical dosimeters have gained special importance in this matter...
December 7, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29214341/sternocostal-slipping-rib-syndrome
#13
Patrick C Bonasso, Shannon N Petrus, Samuel D Smith, Richard J Jackson
PURPOSE: Classical slipping rib syndrome (SRS) can be subclassified based on anatomical location. We describe our experience with three patients suffering from symptomatic sternocostal slipping rib syndrome (SCSRS), a much less common variant of SRS. METHODS: This was a retrospective review of patients with SRS from 1988 to 2016. Described is our experience. RESULTS: Of 44 patients identified with SRS, three patients underwent operations for SCSRS variant...
December 6, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29210582/a-selective-suppression-of-stimulated-raman-scattering-with-another-competing-stimulated-raman-scattering
#14
Doyeon Kim, Dae Sik Choi, Jiwoong Kwon, Sang-Hee Shim, Hanju Rhee, Minhaeng Cho
A three-beam femtosecond stimulated Raman scattering (SRS) scheme is formulated and demonstrated to simultaneously induce two different SRS processes associated with Raman-active modes in the same molecule. Two SR gains involving a common pump pulse are coupled and compete: as one of the Stokes beam intensities increases, the other SRS is selectively suppressed. We provide theoretical description and experimental evidence that the selective suppression behavior is due to the limited number of pump photons used for both two SRS processes when an intense depletion beam induces one SRS process...
December 6, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29209960/systematic-reviews-meta-analyses-of-integrative-medicine-in-chinese-need-regulation-and-monitoring-urgently-and-some-suggestions-for-its-solutions
#15
Jia-Ying Wang, Gui-Hua Tian, You-Ping Li, Tai-Xiang Wu, Zhao-Xiang Bian, Liang Du, Hong-Cai Shang
With the introduction and development of evidence-based medicine in China, it has been spread rapidly in the area of integrative medicine (IM) and has become a new unique discipline. During almost 20 years, as one of the most important parts of evidence-based IM, systematic review (SR)/meta-analysis (MA) of IM have shown a good development momentum in the aspects of quantity, depth, breadth and influence, but also face the harsh situation of the uncontrolled quantity and quality, especially for SRs in Chinese...
December 5, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29208054/unpublished-systematic-reviews-and-financial-support-a-meta-epidemiological-study
#16
Hiraku Tsujimoto, Yasushi Tsujimoto, Yuki Kataoka
OBJECTIVE: PROSPERO, an international prospective register of systematic reviews, was launched in February 2011 to reduce publication bias of systematic reviews (SRs). A questionnaire survey of SR researchers conducted in 2005 indicated the existence of unpublished SRs and the potential influence of lack of funding as a reason for non-publication. Here, we investigated the publication status of registered SRs in the 1st year that PROSPERO launched and assessed the association between publication and the existence of funding or conflicts of interest (COIs)...
December 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29205177/evaluation-of-latent-variances-in-monte-carlo-dose-calculations-with-varian-truebeam-photon-phase-spaces-used-as-a-particle-source
#17
Eyad Ali Alhakeem, Sergei F Zavgorodni
<b>Purpose:</b> To evaluate the latent variance (LV) of Varian TrueBeam photon phase-space files (PSF) for open 10x10 cm<sup>2</sup> and small stereotactic fields and estimate the number of phase spaces required to be summed up in order to maintain sub-percent latent variance in Monte Carlo (MC) dose calculations. <b>Method:</b> BEAMnrc/DOSXYZnrc software was used to transport particles from Varian phase-space files (PSFA) through the secondary collimators. Transported particles were scored into another phase-space located under the jaws (PSFB), or transported further through the cone collimators and scored straight below, forming PSFC...
December 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29204841/stereotactic-radiosurgery-for-central-nervous-system-hemangioblastoma-systematic-review-and-meta-analysis
#18
REVIEW
James Pan, Rashad Jabarkheel, Yuhao Huang, Allen Ho, Steven D Chang
Hemangioblastomas are rare, benign, vascular tumors of the central nervous system (CNS), often associated with von-hippel lindau (VHL) disease. Current therapeutic options include microsurgical resection or stereotactic radiosurgery (SRS). With no randomized controlled studies and minimal data beyond single-institution reviews, the optimal management approach for patients with CNS hemangioblastomas is unclear. We completed a Pubmed/SCOPUS literature search from January 1990 to January 2017 for eligible studies on SRS for CNS hemangioblastomas...
December 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29204838/volumetric-response-of-progressing-post-srs-lesions-treated-with-laser-interstitial-thermal-therapy
#19
Vivek B Beechar, Sujit S Prabhu, Dhiego Bastos, Jeffrey S Weinberg, R Jason Stafford, David Fuentes, Kenneth R Hess, Ganesh Rao
We analyzed volumetric response of metastatic brain tumors that progressed despite treatment with stereotactic radiosurgery (SRS) after treatment with laser interstitial thermal therapy (LITT). We retrospectively reviewed consecutive patients treated from 1/2012 to 10/2015 with LITT for metastatic brain tumors demonstrating progression after SRS. Volumes were quantified using MRI with contrast-enhanced T1-weighted (T1W) and fluid-attenuated inversion recovery (FLAIR). Fifty lesions from 36 patients were studied...
December 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29204524/distant-intracranial-failure-in-melanoma-brain-metastases-treated-with-stereotactic-radiosurgery-in-the-era-of-immunotherapy-and-targeted-agents
#20
Sahaja Acharya, Mustafaa Mahmood, Daniel Mullen, Deshan Yang, Christina I Tsien, Jiayi Huang, Stephanie M Perkins, Keith Rich, Michael Chicoine, Eric Leuthardt, Joshua Dowling, Gavin Dunn, Jesse Keller, Clifford G Robinson, Christopher Abraham
Purpose: Stereotactic radiosurgery (SRS) in combination with immunotherapy (IMT) or targeted therapy is increasingly being used in the setting of melanoma brain metastases (MBMs). The synergistic properties of combination therapy are not well understood. We compared the distant intracranial failure rates of intact MBMs treated with SRS, SRS + IMT, and SRS + targeted therapy. Methods and materials: Combination therapy was defined as delivery of SRS within 3 months of IMT (anti-CTLA-4 /anti-PD-1 therapy) or targeted therapy (BRAF/MEK inhibitors)...
October 2017: Advances in Radiation Oncology
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