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https://www.readbyqxmd.com/read/29691775/cranial-nerve-outcomes-after-primary-stereotactic-radiosurgery-for-symptomatic-skull-base-meningiomas
#1
Andrew Faramand, Hideyuki Kano, Ajay Niranjan, Stephen A Johnson, Mohab Hassib, Kyung-Jae Park, Yoshio Arai, John C Flickinger, L Dade Lunsford
OBJECTIVE: To evaluate cranial nerve (CN) outcomes after primary stereotactic radiosurgery (SRS) for petroclival, cavernous sinus, and cerebellopontine angle meningiomas. METHODS: From our prospectively maintained database of 2022 meningioma patients who underwent Leksell stereotactic radiosurgery (SRS) during a 30-year interval, we found 98 patients with petroclival, 242 with cavernous sinus, and 55 patients with cerebellopontine angle meningiomas. Primary radiosurgery was performed in 245 patients...
April 24, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29690911/quality-ratings-of-reviews-in-overviews-a-comparison-of-reviews-with-and-without-dual-co-authorship
#2
Dawid Pieper, Andreas Waltering, Jakob Holstiege, Roland Brian Büchter
BACKGROUND: Previous research shows that many authors of Cochrane overviews were also involved in some of the included systematic reviews (SRs). This type of dual (co-)authorship (DCA) may be a conflict of interest and a potential source of bias. Our objectives were to (1) additionally investigate DCA in non-Cochrane overviews; (2) investigate whether there is an association between DCA and quality assessments of SRs in Cochrane and non-Cochrane overviews. METHODS: We selected a sample of Cochrane (n = 20) and non-Cochrane (n = 78) overviews for analysis...
April 24, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29689602/buffer-gas-additives-modifiers-shift-reagents-in-ion-mobility-spectrometry-applications-predictions-of-mobility-shifts-and-influence-of-interaction-energy-and-structure
#3
REVIEW
Roberto Fernandez-Maestre
Ion mobility spectrometry (IMS) is an analytical technique used for fast and sensitive detection of illegal substances in customs and airports, diagnosis of diseases through detection of metabolites in breath, fundamental studies in physics and chemistry, space exploration and many more applications. IMS separates ions in the gas-phase drifting under an electric field according to their size to charge ratio. IMS disadvantages are false positives that delay transportation, compromise patient's health and other negative issues when IMS is used for detection...
April 24, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29688562/stereotactic-radiosurgery-for-trigeminal-neuralgia-in-patients-with-multiple-sclerosis-a-multicenter-study
#4
Zhiyuan Xu, David Mathieu, France Heroux, Mahmoud Abbassy, Gene Barnett, Alireza M Mohammadi, Hideyuki Kano, James Caruso, Han-Hsun Shih, Inga S Grills, Kuei Lee, Sandeep Krishnan, Anthony M Kaufmann, John Y K Lee, Michelle Alonso-Basanta, Marie Kerr, John Pierce, Douglas Kondziolka, Judith A Hess, Jason Gerrard, Veronica Chiang, L Dade Lunsford, Jason P Sheehan
BACKGROUND: Facial pain response (PR) to various surgical interventions in patients with multiple sclerosis (MS)-related trigeminal neuralgia (TN) is much less optimal. No large patient series regarding stereotactic radiosurgery (SRS) has been published. OBJECTIVE: To evaluate the clinical outcomes of MS-related TN treated with SRS. METHODS: This is a retrospective cohort study. A total of 263 patients contributed by 9 member tertiary referral Gamma Knife centers (2 in Canada and 7 in USA) of the International Gamma Knife Research Consortium (IGKRF) constituted this study...
April 23, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29688510/study-protocol-early-stereotactic-gamma-knife-radiosurgery-to-residual-tumor-after-surgery-of-newly-diagnosed-glioblastoma-gamma-gbm
#5
Stefanie Brehmer, Mario Alexander Grimm, Alex Förster, Marcel Seiz-Rosenhagen, Grit Welzel, Florian Stieler, Frederik Wenz, Christoph Groden, Sabine Mai, Daniel Hänggi, Frank Anton Giordano
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adult patients. Tumor recurrence commonly occurs around the resection cavity, especially after subtotal resection (STR). Consequently, the extent of resection correlates with overall survival (OS), suggesting that depletion of postoperative tumor remnants will improve outcome. OBJECTIVE: To assess safety and efficacy of adding stereotactic radiosurgery (SRS) to the standard treatment of GBM in patients with postoperative residual tumor...
April 24, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29680768/utilization-of-stereotactic-radiosurgery-for-renal-cell-carcinoma-brain-metastases
#6
Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
BACKGROUND: Because renal cell carcinoma (RCC) has been traditionally considered a "radioresistant" histology, it may be advantageous to treat brain metastases (BMs) with ablative dosing by means of stereotactic radiosurgery (SRS). This is the first known analysis evaluating utilization of SRS for RCC BMs in the United States. METHODS: The National Cancer Data Base was queried (2005-2014) for metastatic RCC and delivery of intracranial radiotherapy. Patients were stratified into groups receiving either SRS or non-SRS treatment...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29680510/srs-schwab-grade-4-osteotomy-for-congenital-thoracolumbar-kyphosis-a-minimum-of-2-years-follow-up-study
#7
Benlong Shi, Qinghua Zhao, Liang Xu, Zhen Liu, Xu Sun, Zezhang Zhu, Yong Qiu
BACKGROUND: Several osteotomy techniques including pedicle subtraction osteotomy and vertebral column resection have been employed in the correction of congenital kyphosis (CK) and satisfying outcomes have been demonstrated. However, the SRS-Schwab Grade 4 osteotomy, defined as resection of posterior elements, partial vertebral body and superior adjacent disc, is rarely reported in the treatment of CK. PURPOSE: To evaluate the efficiency and safety of SRS-Schwab Grade 4 osteotomy in CK patients, and to propose its optimal indication...
April 19, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29678530/improved-overall-survival-and-locoregional-disease-control-with-concurrent-pd-1-pathway-inhibitors-and-stereotactic-radiosurgery-for-lung-cancer-patients-with-brain-metastases
#8
Emily Schapira, Harper Hubbeling, Beow Y Yeap, William A Mehan, Alice T Shaw, Kevin Oh, Justin F Gainor, Helen A Shih
PURPOSE: Despite the emerging role of programmed cell death-1 (PD-1) pathway inhibitors for patients with advanced lung cancer, a paucity of data are available on the activity of these agents among patients with brain metastases. We investigated the outcomes of PD-1 pathway inhibitors and stereotactic radiosurgery (SRS) for the treatment of patients with brain metastases from lung cancer. METHODS AND MATERIALS: We retrospectively reviewed the medical records of non-small-cell lung cancer patients with brain metastases consecutively treated with PD-1 pathway inhibitors and SRS at our institution from 2012 to 2017...
March 22, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678526/long-term-outcomes-after-stereotactic-radiosurgery-for-spine-metastases-radiation-dose-response-for-late-toxicity
#9
Diane C Ling, John C Flickinger, Steven A Burton, Dwight E Heron, Annette E Quinn, Ghassan K Bejjani, Johnathan A Engh, Peter C Gerszten, Nduka M Amankulor, John A Vargo
PURPOSE: To document the 5- and 10-year rates of late toxicity and vertebral compression fracture (VCF) in long-term survivors after stereotactic radiosurgery for spine metastases. METHODS AND MATERIALS: A retrospective review was performed on 562 patients treated with SRS for spine metastases between April 2001 and July 2011. Selecting those with at least 5-year survival after SRS, included were 43 patients who collectively underwent 84 treatments at 54 spine sites...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29678524/hypopituitarism-after-single-fraction-pituitary-adenoma-radiosurgery-dosimetric-analysis-based-on-patients-treated-using-contemporary-techniques
#10
Christopher S Graffeo, Michael J Link, Paul D Brown, William F Young, Bruce E Pollock
PURPOSE: To analyze factors associated with post-stereotactic radiosurgery (SRS) hypopituitarism among radiation-naïve patients with pituitary adenomas who underwent single-fraction SRS between 2007 and 2014. METHODS AND MATERIALS: This was a retrospective review of 97 patients having single-fraction SRS from 2007 until 2014. Eligible patients had no history of prior radiation, normal age- and sex-specific pituitary function before SRS, and at least 24 months of endocrine follow-up...
March 8, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29676690/does-size-matter-investigating-the-optimal-planning-target-volume-margin-for-postoperative-stereotactic-radiosurgery-to-resected-brain-metastases
#11
Jaymin Jhaveri, Mudit Chowdhary, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Matthew J Ferris, Tiffany M Morgan, Justin Roper, Anees Dhabaan, Eric Elder, Bree R Eaton, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Kirtesh R Patel
OBJECTIVE The optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated the effect of SRS planning target volume (PTV) margin on local recurrence and symptomatic radiation necrosis postoperatively. METHODS Records of patients who received postoperative LINAC-based SRS for brain metastases between 2006 and 2016 were reviewed and stratified based on PTV margin size (1.0 or > 1.0 mm). Patients were treated using frameless and framed SRS techniques, and both single-fraction and hypofractionated dosing were used based on lesion size...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29670942/hydrophilic-directional-slippery-rough-surfaces-for-water-harvesting
#12
Xianming Dai, Nan Sun, Steven O Nielsen, Birgitt Boschitsch Stogin, Jing Wang, Shikuan Yang, Tak-Sing Wong
Multifunctional surfaces that are favorable for both droplet nucleation and removal are highly desirable for water harvesting applications but are rare. Inspired by the unique functions of pitcher plants and rice leaves, we present a hydrophilic directional slippery rough surface (SRS) that is capable of rapidly nucleating and removing water droplets. Our surfaces consist of nanotextured directional microgrooves in which the nanotextures alone are infused with hydrophilic liquid lubricant. We have shown through molecular dynamics simulations that the physical origin of the efficient droplet nucleation is attributed to the hydrophilic surface functional groups, whereas the rapid droplet removal is due to the significantly reduced droplet pinning of the directional surface structures and slippery interface...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29667141/triplanar-correction-of-adolescent-idiopathic-scoliosis-by-asymmetrically-shaped-and-simultaneously-applied-rods-associated-with-direct-vertebral-rotation-clinical-and-radiological-analysis-of-36-patients
#13
Cesare Faldini, Fabrizio Perna, Giuseppe Geraci, Francesco Pardo, Antonio Mazzotti, Federico Pilla, Alberto Ruffilli
PURPOSE: Aim of this study was to investigate the effectiveness of a new surgical corrective manoeuvre for adolescent idiopathic scoliosis (AIS) by asymmetrically shaped and simultaneously applied rods and in combination with direct vertebral rotation, to control both the triplanar deformity and the kyphosis apex location. METHODS: We retrospectively reviewed 36 patients who undergo surgical treatment using simultaneous translation on two differently contoured rods, in combination with direct vertebral rotation...
April 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29667079/fetal-regional-myocardial-strain-rate-in-the-membranous-ventricular-septum-changes-with-gestational-age-and-the-left-ventricular-mass-and-predictive-value-for-a-complete-membranous-ventricular-septum-without-defect
#14
Li-Juan Zhang, Ke-Qi Chen, Yun-Yan Shi, Xiao-Zhi Zheng
To describe the fetal regional myocardial strain rate in the membranous ventricular septum across gestation and to determine their predictive value for a complete membranous ventricular septum (without defect) after delivery. In 1150 fetuses, the peak systolic strain rate (SRs), peak early diastolic strain rate (SRe) and peak late diastolic strain rate (SRa) in the membranous ventricular septum were measured at four time points across gestation (18-20, 24-26, 30-32 and 36-38 weeks). The integrity of the interventricular septum was examined at 12 weeks' postnatal age...
April 17, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29666135/study-protocol-for-the-saron-trial-a-multicentre-randomised-controlled-phase-iii-trial-comparing-the-addition-of-stereotactic-ablative-radiotherapy-and-radical-radiotherapy-with-standard-chemotherapy-alone-for-oligometastatic-non-small-cell-lung-cancer
#15
John Conibear, Brendan Chia, Yenting Ngai, Andrew Tom Bates, Nicholas Counsell, Rushil Patel, David Eaton, Corinne Faivre-Finn, John Fenwick, Martin Forster, Gerard G Hanna, Susan Harden, Philip Mayles, Syed Moinuddin, David Landau
INTRODUCTION: Following growing evidence to support the safety, local control (LC) and potential improvement in overall survival (OS) in patients with oligometastatic non-small cell lung cancer (NSCLC) that have been treated with local ablative therapy such as stereotactic ablative radiotherapy (SABR) and stereotactic radiosurgery (SRS), we initiate the SARON trial to investigate the impact and feasibility of adding SABR/SRS and radical radiotherapy (RRT) following standard chemotherapy on OS...
April 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29664852/lower-extremity-motor-function-following-complex-adult-spinal-deformity-surgery-two-year-follow-up-in-the-scoli-risk-1-prospective-multicenter-international-study
#16
Lawrence G Lenke, Christopher I Shaffrey, Leah Y Carreon, Kenneth M C Cheung, Benny T Dahl, Michael G Fehlings, Christopher P Ames, Oheneba Boachie-Adjei, Mark B Dekutoski, Khaled M Kebaish, Stephen J Lewis, Yukihiro Matsuyama, Hossein Mehdian, Ferran Pellisé, Yong Qiu, Frank J Schwab
BACKGROUND: The reported neurologic complication rate following surgery for complex adult spinal deformity (ASD) is variable due to several factors. Most series have been retrospective with heterogeneous patient populations and use of nonuniform neurologic assessments. The aim of this study was to prospectively document lower extremity motor function by means of the American Spinal Injury Association (ASIA) lower extremity motor score (LEMS) before and through 2 years after surgical correction of complex ASD...
April 18, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29664812/health-related-quality-of-life-and-body-image-disturbance-of-adolescents-with-severe-untreated-idiopathic-early-onset-scoliosis-in-a-developing-country
#17
Hany Abdel Gawwad Soliman
STUDY DESIGN: A cross sectional study OBJECTIVE.: This study aimed to investigate the health-related quality of life (HRQOL) and body image disturbance of adolescents with untreated severe idiopathic early-onset scoliosis (IEOS) in a developing country. SUMMARY OF BACKGROUND DATA: IEOS has the potential to progress rapidly and may lead to significant disability if left untreated. Moreover, it can lead to significant body image changes that may lead to social and psychological stresses on developing adolescents...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29662739/decompression-in-adult-lumbar-deformity-surgery-is-associated-with-increased-perioperative-complications-but-favorable-long-term-outcomes
#18
Isaac O Karikari, Keith H Bridwell, Aladine A Elsamadicy, Lawrence G Lenke, Patrick Sugrue, David Bumpass, Azeem Ahmad, Jeffrey Gum
Study Design: Retrospective cohort study. Objectives: To analyze the impact of performing a formal decompression in patients with adult lumbar scoliosis with symptomatic spinal stenosis on perioperative complications and long-term outcomes. Methods: Adult patients undergoing at least 5 levels of fusion to the sacrum with iliac fixation from 2002 to 2008 who had a minimum 5-year follow-up at one institution were studied. Patients who had 3-column osteotomy were excluded from the study...
April 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29661275/preinjury-statin-use-and-thromboembolic-events-in-trauma-a-10-year-retrospective-evaluation
#19
Ryan A McMahon, John L Fletcher, James K Aden, Seth R Holland, Scott T Trexler, Lorne H Blackbourne
BACKGROUND: Traumatic injury is well known to increase the risk of venous thromboembolic events (VTEs), occurring in up to 58% of trauma patients. Statin medications have significant anti-inflammatory properties and have been shown to reduce the risk of VTE. We hypothesized that trauma patients who received statin medication before injury would have a lower incidence of VTE after injury. METHODS: A 10-y retrospective review identified all patients admitted to our trauma service with an injury severity score >9 and an intensive care unit stay of >3 d...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29659920/chromosome-14q32-2-imprinted-region-disruption-as-an-alternative-molecular-diagnosis-of-silver-russell-syndrome
#20
Sophie Geoffron, Walid Abi Habib, Sandra Chantot-Bastaraud, Béatrice Dubern, Virginie Steunou, Salah Azzi, Alexandra Afenjar, Tiffanny Busa, Ana P Canton, Christel Chalouhi, Marie-Noëlle Dufourg, Blandine Esteva, Mélanie Fradin, David Geneviève, Solveig Heide, Bertrand Isidor, Agnès Linglart, Fanny Morice Picard, Catherine Naud-Saudreau, Isabelle Oliver Petit, Nicole Philip, Catherine Pienkowski, Marlène Rio, Sylvie Rossignol, Maithé Tauber, Julien Thevenon, Thuy-Ai Vu-Hong, Madeleine D Harbison, Jennifer Salem, Frédéric Brioude, Irène Netchine, Eloïse Giabicani
Context: Silver-Russell syndrome (SRS) (mainly secondary to 11p15 molecular disruption) and Temple syndrome (TS) (secondary to 14q32.2 molecular disruption) are imprinting disorders with phenotypic (prenatal and postnatal growth retardation, early feeding difficulties) and molecular overlap. Objective: To describe the clinical overlap between SRS and TS and extensively study the molecular aspects of TS. Patients: We retrospectively collected data on 28 patients with disruption of the 14q32...
April 11, 2018: Journal of Clinical Endocrinology and Metabolism
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