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https://www.readbyqxmd.com/read/28718316/predictors-of-complications-and-readmission-following-spinal-stereotactic-radiosurgery
#1
Daniel Lubelski, Joseph E Tanenbaum, Taylor E Purvis, Thomas T Bomberger, Courtney Rory Goodwin, Ilya Laufer, Daniel M Sciubba
AIM: to identify preoperative factors associated with morbidity/mortality, hospital length of stay (LOS), 30-day readmission and operation rates following spinal stereotactic radiosurgery (SRS) for spinal tumors. METHODS: The American College of Surgeons National Quality Improvement Program was queried from 2012 to 2014 to identify patients undergoing SRS for spinal tumors. Logistic regression was performed to identify predictors. RESULTS: 2714 patients were identified; 6...
July 18, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28716082/efficacy-of-hormonal-and-mental-treatments-with-mmpi-in-ftm-individuals-cross-sectional-and-longitudinal-studies
#2
Hiroyuki Oda, Toshihiko Kinoshita
BACKGROUND: Cross-sex hormone treatment (CSHT) is an important option for gender dysphoria (GD) individuals to improve the quality of life. However, in Japan, sex reassignment surgery (SRS) and CSHT for GD had been discontinued until 1998 (over 30 years). After resumption, the number of GD individuals wishing treatment rapidly increased. On the other hand, the number of medical institutions available for evaluation was limited. For this reason, hormonal treatment has been administered to GD individuals requiring the prompt start of CSHT in the absence of mental health assessment by specialists...
July 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28716058/srf-modulates-seizure-occurrence-activity-induced-gene-transcription-and-hippocampal-circuit-reorganization-in-the-mouse-pilocarpine-epilepsy-model
#3
Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer Zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic, Bernd Knöll
A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as Fos and Egr1.We employed the mouse pilocarpine model to analyze the transcription factor (TF) serum response factor (SRF) in epileptogenesis, seizure induced histopathology and IEG induction. SRF is a neuronal activity regulated TF stimulating IEG expression as well as nerve fiber growth and guidance...
July 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28715124/chemical-imaging-of-fresh-vascular-smooth-muscle-cell-response-by-epi-detected-stimulated-raman-scattering
#4
Delong Zhang, Wei Chen, Huan Chen, Han-Qing Yu, Ghassan Kassab, Ji-Xin Cheng
An understanding of deformation of cardiovascular tissue under hemodynamic load is crucial for understanding the health and disease of blood vessels. In the present work, an epi-detected stimulated Raman scattering (epi-SRS) imaging platform was designed for in situ functional imaging of vascular smooth muscle cells (VMSCs) in fresh coronary arteries. For the first time, the pressure-induced morphological deformation of fresh VSMCs was imaged with no fixation and in a label free manner. The relation between the loading pressure and the morphological parameters, including angle and length of the VSMCs, were apparent...
July 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28714067/evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#5
Yujiao Qin, Stephen J Gardner, Joshua Kim, Yimei Huang, Ning Wen, Anthony Doemer, Indrin J Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance (QA) measurements using flattening-filter-free beam. METHODS: A total of ten spherical targets (volume range: [0.03cc-2cc]) were planned with two techniques: (1) Dynamic Conformal Arc (DCA-10 plans), and (2) Volumetric Modulated Arc Therapy (VMAT-10 plans). All plans were generated using Varian Eclipse treatment planning system, and AcurosXB v...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28711334/fully-automated-comprehensive-knowledge-based-planning-for-stereotactic-radiosurgery-preclinical-validation-through-blinded-physician-review
#6
Benjamin P Ziemer, Satomi Shiraishi, Jona A Hattangadi-Gluth, Parag Sanghvi, Kevin Lawrence Moore
PURPOSE: As knowledge-based planning (KBP) attempts to augment and potentially supplant manual treatment planning, it is imperative to ensure any implementation maintains or improves overall plan quality in any disease site. The purpose of this study was to demonstrate the overall quality of KBP-driven automated stereotactic radiosurgery (SRS) treatment planning using blinded physician comparison and determine systematic factors predictive of physician plan preference to guide future KBP refinement...
April 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28710613/self-retaining-support-implant-an-anchorless-system-for-the-treatment-of-pelvic-organ-prolapse-2-year-follow-up
#7
Gil Levy, Anna Padoa, Zoltan Fekete, George Bartfai, Laszlo Pajor, Mauro Cervigni
INTRODUCTION AND HYPOTHESIS: The search for an improved vaginal mesh prompted the development of a new anchorless implant. The objective was to report on outcome after 2 years of a technique using a self-retaining support (SRS) implant. METHODS: Patients with anterior vaginal wall prolapse, with/without apical prolapse, were recruited. Participants underwent surgical repair using the SRS device. Demographic data, pre-surgical Pelvic Organ Prolapse Quantification (POP-Q) scoring, quality of life (QoL) questionnaires (Pelvic Floor Distress Inventory Short Form 20 [PFDI-20], Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire 12 [PISQ-12]), and surgical data were collected...
July 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28710086/onyx-embolization-prior-to-stereotactic-radiosurgery-for-brain-arteriovenous-malformations-a-single-center-treatment-algorithm
#8
John D Nerva, Jason Barber, Michael R Levitt, Jason K Rockhill, Danial K Hallam, Basavaraj V Ghodke, Laligam N Sekhar, Louis J Kim
BACKGROUND: Embolization before stereotactic radiosurgery (SRS) for brain arteriovenous malformations (BAVMs) is controversial. OBJECTIVE: To compare clinical and radiographic outcomes in patients undergoing pre-SRS embolization with ethylene copolymer (Onyx) with outcomes in patients undergoing SRS alone. METHODS: Seventy consecutive patients with BAVMs who underwent SRS were retrospectively reviewed. Univariate and multivariate analyses were performed to assess the factors associated with radiographic obliteration and complication...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28709615/transcriptional-profiling-of-rickettsia-prowazekii-coding-and-non-coding-transcripts-during-in-vitro-host-pathogen-and-vector-pathogen-interactions
#9
Casey L C Schroeder, Hema P Narra, Abha Sahni, Kamil Khanipov, Jignesh Patel, Yuriy Fofanov, Sanjeev K Sahni
Natural pathogen transmission of Rickettsia prowazekii, the etiologic agent of epidemic typhus, to humans is associated with arthropods, including human body lice, ticks, and ectoparasites of eastern flying squirrel. Recently, we have documented the presence of small RNAs in Rickettsia species and expression of R. prowazekii sRNAs during infection of cultured human microvascular endothelial cells (HMECs), which represent the primary target cells during human infections. Bacterial noncoding transcripts are now well established as critical post-transcriptional regulators of virulence and adaptation mechanisms in varying host environments...
June 29, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28709138/multimodal-nonlinear-microscope-based-on-a-compact-fiber-format-laser-source
#10
Francesco Crisafi, Vikas Kumar, Antonio Perri, Marco Marangoni, Giulio Cerullo, Dario Polli
We present a multimodal non-linear optical (NLO) laser-scanning microscope, based on a compact fiber-format excitation laser and integrating coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS) and two-photon-excitation fluorescence (TPEF) on a single platform. We demonstrate its capabilities in simultaneously acquiring CARS and SRS images of a blend of 6-μm poly(methyl methacrylate) beads and 3-μm polystyrene beads. We then apply it to visualize cell walls and chloroplast of an unprocessed fresh leaf of Elodea aquatic plant via SRS and TPEF modalities, respectively...
July 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28707997/gamma-knife-radiosurgery-for-large-vestibular-schwannomas-greater-than-3-cm-in-diameter
#11
Cheng-Wei Huang, Hsien-Tang Tu, Chun-Yi Chuang, Cheng-Siu Chang, Hsi-Hsien Chou, Ming-Tsung Lee, Chuan-Fu Huang
OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors reviewed their recent experience to assess the potential role of SRS in larger-sized VSs. METHODS Between 2000 and 2014, 35 patients with large VSs, defined as having both a single dimension > 3 cm and a volume > 10 cm(3), underwent Gamma Knife radiosurgery (GKRS)...
July 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28697206/an-overview-of-systematic-reviews-related-to-aspects-of-the-shortened-dental-arch-and-its-variants-in-adults
#12
Saadika B Khan, Usuf Me Chikte, Ridwaan Omar
PURPOSE: The aim of this study was to conduct an overview of systematic reviews (SRs) related to aspects of the shortened dental arch (SDA) and its variants and critically appraise the methodologic quality of included SRs using the AMSTAR checklist. MATERIALS AND METHODS: A comprehensive computerized search and a hand search of reference lists were conducted for SRs related to SDAs to identify publications from 2000 to 2016. All the present authors and a research assistant independently screened the results of the electronic searches using an eligibility form and extracted information using a specially designed prepiloted data extraction form...
July 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28696286/intranasal-oxytocin-treatment-for-social-deficits-and-biomarkers-of-response-in-children-with-autism
#13
Karen J Parker, Ozge Oztan, Robin A Libove, Raena D Sumiyoshi, Lisa P Jackson, Debra S Karhson, Jacqueline E Summers, Kyle E Hinman, Kara S Motonaga, Jennifer M Phillips, Dean S Carson, Joseph P Garner, Antonio Y Hardan
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in part, because existing medications target only associated ASD features. Emerging evidence suggests that the neuropeptide oxytocin (OXT) may be a blood-based biomarker of social functioning and a possible treatment for ASD. However, prior OXT treatment trials have produced equivocal results, perhaps because of variability in patients' underlying neuropeptide biology, but this hypothesis has not been tested. Using a double-blind, randomized, placebo-controlled, parallel design, we tested the efficacy and tolerability of 4-wk intranasal OXT treatment (24 International Units, twice daily) in 32 children with ASD, aged 6-12 y...
July 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28695968/robotic-assisted-radical-prostatectomy-with-the-use-of-barbed-sutures
#14
Angelo Porreca, Antonio Salvaggio, Matteo Dandrea, Emanuele Cappa, Alessio Zuccala, Alessandro Del Rosso, Daniele D'Agostino
OBJECTIVES: The aim of this study is to analyze the principal advantages of posterior muscolo-fascial reconstruction using knotless barbed sutures (BS) during robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS: We analyzed the available evidence regarding the efficacy and safety of principal BS (Quill™ SRS Angiotech Pharmaceuticals Inc., Vancouver, Canada; V-Loc™ Medtronic, Dublin, Ireland; STRATAFIX™ Ethicon Inc., Somerville, New Jersey; Filbloc® Assut Europe S...
July 11, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28693442/evaluation-of-the-relationship-between-marco-and-cd36-single-nucleotide-polymorphisms-and-susceptibility-to-pulmonary-tuberculosis-in-a-chinese-han-population
#15
Wenting Lao, Hui Kang, Guojiang Jin, Li Chen, Yang Chu, Jiao Sun, Bingqi Sun
BACKGROUND: Gene polymorphisms impact greatly on a person's susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosis infection. Gene polymorphisms of MARCO and CD36 may contribute to tuberculosis risk. METHODS: To investigate whether genetic polymorphisms of MARCO and CD36 are associated with susceptibility to PTB, genomic DNA samples from patients (n = 202) and healthy controls (n = 216) were collected and analyzed by polymerase chain reaction with high-resolution melting analysis...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28690616/comparative-transcriptome-analysis-reveals-critical-function-of-sucrose-metabolism-related-enzymes-in-starch-accumulation-in-the-storage-root-of-sweet-potato
#16
Kai Zhang, Zhengdan Wu, Daobin Tang, Kai Luo, Huixiang Lu, Yingying Liu, Jie Dong, Xin Wang, Changwen Lv, Jichun Wang, Kun Lu
The starch properties of the storage root (SR) affect the quality of sweet potato (Ipomoea batatas (L.) Lam.). Although numerous studies have analyzed the accumulation and properties of starch in sweet potato SRs, the transcriptomic variation associated with starch properties in SR has not been quantified. In this study, we measured the starch and sugar contents and analyzed the transcriptome profiles of SRs harvested from sweet potatoes with high, medium, and extremely low starch contents, at five developmental stages [65, 80, 95, 110, and 125 days after transplanting (DAP)]...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28689306/targeted-spine-strengthening-exercise-and-posture-training-program-to-reduce-hyperkyphosis-in-older-adults-results-from-the-study-of-hyperkyphosis-exercise-and-function-sheaf-randomized-controlled-trial
#17
W B Katzman, E Vittinghoff, F Lin, A Schafer, R K Long, S Wong, A Gladin, B Fan, B Allaire, D M Kado, N E Lane
A 6-month randomized controlled trial of spine-strengthening exercise and posture training reduced both radiographic and clinical measures of kyphosis. Participants receiving the intervention improved self-image and satisfaction with their appearance. Results suggest that spine-strengthening exercise and postural training may be an effective treatment option for older adults with hyperkyphosis. INTRODUCTION: The purpose of the present study is to determine in a randomized controlled trial whether spine-strengthening exercises improve Cobb angle of kyphosis in community-dwelling older adults...
July 8, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28688984/patient-profiling-can-identify-adult-spinal-deformity-asd-patients-at-risk-for-conversion-from-nonoperative-to-surgical-treatment-initial-steps-to-reduce-ineffective-asd-management
#18
Peter G Passias, Cyrus M Jalai, Breton G Line, Gregory W Poorman, Justin K Scheer, Justin S Smith, Christopher I Shaffrey, Douglas C Burton, Kai-Ming G Fu, Eric O Klineberg, Robert A Hart, Frank Schwab, Virginie Lafage, Shay Bess
BACKGROUND CONTEXT: Non-operative management is a common initial treatment for adult spinal deformity (ASD) patients despite reported superiority of surgery with regard to outcomes. Ineffective medical care is a large source of resource drain on the health system. Characterization of ASD patients likely to elect for operative treatment from nonoperative management may allow for more efficient patient counseling and cost savings. PURPOSE: To identify deformity and disability characteristics of ASD patients that ultimately convert to operative treatment compared to those that remain non-operative and those that initially choose surgery...
July 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28687377/postoperative-stereotactic-radiosurgery-compared-with-whole-brain-radiotherapy-for-resected-metastatic-brain-disease-ncctg-n107c-cec%C3%A2-3-a-multicentre-randomised-controlled-phase-3-trial
#19
Paul D Brown, Karla V Ballman, Jane H Cerhan, S Keith Anderson, Xiomara W Carrero, Anthony C Whitton, Jeffrey Greenspoon, Ian F Parney, Nadia N I Laack, Jonathan B Ashman, Jean-Paul Bahary, Costas G Hadjipanayis, James J Urbanic, Fred G Barker, Elana Farace, Deepak Khuntia, Caterina Giannini, Jan C Buckner, Evanthia Galanis, David Roberge
BACKGROUND: Whole brain radiotherapy (WBRT) is the standard of care to improve intracranial control following resection of brain metastasis. However, stereotactic radiosurgery (SRS) to the surgical cavity is widely used in an attempt to reduce cognitive toxicity, despite the absence of high-level comparative data substantiating efficacy in the postoperative setting. We aimed to establish the effect of SRS on survival and cognitive outcomes compared with WBRT in patients with resected brain metastasis...
July 4, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28687375/post-operative-stereotactic-radiosurgery-versus-observation-for-completely-resected-brain-metastases-a-single-centre-randomised-controlled-phase-3-trial
#20
Anita Mahajan, Salmaan Ahmed, Mary Frances McAleer, Jeffrey S Weinberg, Jing Li, Paul Brown, Stephen Settle, Sujit S Prabhu, Frederick F Lang, Nicholas Levine, Susan McGovern, Erik Sulman, Ian E McCutcheon, Syed Azeem, Daniel Cahill, Claudio Tatsui, Amy B Heimberger, Sherise Ferguson, Amol Ghia, Franco Demonte, Shaan Raza, Nandita Guha-Thakurta, James Yang, Raymond Sawaya, Kenneth R Hess, Ganesh Rao
BACKGROUND: After brain metastasis resection, whole brain radiotherapy decreases local recurrence, but might cause cognitive decline. We did this study to determine if stereotactic radiosurgery (SRS) to the surgical cavity improved time to local recurrence compared with that for surgical resection alone. METHODS: In this randomised, controlled, phase 3 trial, we recruited patients at a single tertiary cancer centre in the USA. Eligible patients were older than 3 years, had a Karnofsky Performance Score of 70 or higher, were able to have an MRI scan, and had a complete resection of one to three brain metastases (with a maximum diameter of the resection cavity ≤4 cm)...
July 4, 2017: Lancet Oncology
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