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https://www.readbyqxmd.com/read/28213861/peri-operative-allogeneic-blood-transfusion-and-outcomes-after-radical-cystectomy-a-population-based-study
#1
D Robert Siemens, Melanie T Jaeger, Xuejiao Wei, Francisco Vera-Badillo, Christopher M Booth
INTRODUCTION: To describe factors associated with peri-operative blood transfusion (PBT) at radical cystectomy (RC) for patients with bladder cancer and evaluate its association on both early and late outcomes. METHODS: Electronic records of treatment and surgical pathology reports were linked to the population-based Ontario Cancer Registry to identify all patients who underwent RC between 2000 and 2008. Modified Poisson regression model was used to determine the factors associated with PBT...
February 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28181538/epigenetic-editing-of-ascl1-gene-in-neural-stem-cells-by-optogenetics
#2
Chiao-Ling Lo, Samrat Roy Choudhury, Joseph Irudayaraj, Feng C Zhou
Enzymes involved in epigenetic processes such as methyltransferases or demethylases are becoming highly utilized for their persistent DNA or histone modifying efficacy. Herein, we have developed an optogenetic toolbox fused to the catalytic domain (CD) of DNA-methyltransferase3A (DNMT3A-CD) or Ten-Eleven Dioxygenase-1 (TET1-CD) for loci-specific alteration of the methylation state at the promoter of Ascl1 (Mash1), a candidate proneuron gene. Optogenetical protein pairs, CRY2 linked to DNMT3A-CD or TET1-CD and CIB1 fused to a Transcription Activator-Like Element (TALE) locating an Ascl1 promoter region, were designed for site specific epigenetic editing...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28169926/variation-in-the-utilization-of-minimally-invasive-surgical-operations
#3
Lindsay E Kuo, Kenric Murayama, Kristina D Simmons, Rachel R Kelz
OBJECTIVE: The goal of this study was to examine regional variation in use of minimally invasive surgical (MIS) operations. SUMMARY BACKGROUND DATA: Regional variation exists in performance of surgical operations. Variation in the use of MIS has not been studied. METHODS: Five operations that are performed open or MIS were selected: cholecystectomy, appendectomy, colectomy, antireflux, and bariatric. A 3-state database from 2008 to 2011 was used; states were divided into hospital service areas (HSAs)...
March 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28162926/-effectiveness-of-an-intervention-to-improve-safety-culture-less-is-more
#4
J J López-Picazo, P Ferrer-Bas, B Garrido-Corro, V Pujalte-Ródenas, P de la Cruz Murie, M Blázquez-Pedrero, S Sánchez-Lorca, P Soler-Gallego, C Albacete-Moreno, T Alcaraz-Pérez, S Pérez-Romero
OBJECTIVE: To assess the impact of a long-term initiative to improve safety culture among professionals working in a Health Area, and to know their perceived usefulness. MATERIAL AND METHODS: An uncontrolled intervention study was designed in a public health care organization including a 3rd level hospital and 5,000 professionals. To measure the impact, the AHRQ Survey was conducted by telephone. A total of 7 dimensions of culture were measured, before starting the project (2012, n=100) and 3 years later (2015, n=207)...
February 2, 2017: Revista de Calidad Asistencial: Organo de la Sociedad Española de Calidad Asistencial
https://www.readbyqxmd.com/read/28156538/variation-in-utilization-of-palliative-surgery-in-patients-with-metastatic-colorectal-cancer
#5
Hari Nathan, Scott E Regenbogen, Samantha Hendren, Arden M Morris, Pasithorn Amy Suwanabol
: 120 Background: Twenty-five percent of patients with colorectal cancer will present with unresectable disease. Palliative surgery has been shown to improve symptom control and improve patient satisfaction as well as demonstrate improved cost and decreased healthcare utilization. However, it is unclear what factors influence use. We sought to determine patient and hospital factors associated with palliative surgery use in advanced colorectal cancers. METHODS: Using the National Cancer Data Base (NCDB) Participant User File from 2006 to 2012, 162,967 patients with metastatic colorectal cancer were identified...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151760/titin-truncating-mutations-in-dilated-cardiomyopathy-the-long-and-short-of-it
#6
Diane Fatkin, Inken G Huttner
PURPOSE OF REVIEW: Truncating variants in the TTN gene (TTNtv) are frequently identified in patients with dilated cardiomyopathy (DCM) but are also present in apparently healthy people in the general population. Consequently, there is considerable uncertainty about what it means for any single individual if a TTNtv is found. The aim of this review is to summarize current evidence implicating TTNtv in DCM pathogenesis and to provide some interpretative guidelines for clinical management...
February 1, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28149949/cyp450-enzymes-effect-oxygen-dependent-reduction-of-azide-based-fluorogenic-dyes
#7
Liam J O'Connor, Ishna N Mistry, Sarah L Collins, Lisa K Folkes, Graham Brown, Stuart J Conway, Ester M Hammond
Azide-containing compounds have broad utility in organic synthesis and chemical biology. Their use as powerful tools for the labeling of biological systems in vitro has enabled insights into complex cellular functions. To date, fluorogenic azide-containing compounds have primarily been employed in the context of click chemistry and as sensitive functionalities for hydrogen sulfide detection. Here, we report an alternative use of this functionality: as fluorogenic probes for the detection of depleted oxygen levels (hypoxia)...
January 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28135211/clinical-assessment-of-the-impact-of-pelvic-pain-on-women
#8
K Jane Chalmers, Mark J Catley, Susan F Evans, G Lorimer Moseley
We aimed to develop a questionnaire that assesses the impact of pelvic pain on women, regardless of diagnosis, that has high utility, sound psychometric performance, easy scoring, and high reliability. Two studies, with 3 separate cohorts, were undertaken. Both studies were completed online. Studies included women with self-reported pelvic pain. Women were eligible to participate regardless of whether their pelvic pain was undiagnosed, self-diagnosed, or diagnosed by a clinician. Study 1 used a 3-round "patient-as-expert" Delphi technique...
March 2017: Pain
https://www.readbyqxmd.com/read/28122848/developing-a-patient-and-family-research-advisory-panel-to-include-people-with-significant-disease-multimorbidity-and-advanced-age
#9
Laura B Portalupi, Carmen L Lewis, Carl D Miller, Kerry L Whiteman-Jones, Kay A Sather, Donald E Nease, Daniel D Matlock
BACKGROUND: People who have experienced illness due to significant disease, multimorbidity and/or advanced age are high utilizers of the health care system. Yet this population has had little formal opportunity to participate in guiding the health care research agenda, and few mechanisms exist for researchers to engage this population in an efficient way. OBJECTIVE: We describe the process of developing a standing patient and family advisory panel to incorporate this population's voice into research in the USA...
January 24, 2017: Family Practice
https://www.readbyqxmd.com/read/28118861/a-report-of-the-efforts-of-the-veterans-health-administration-national-antimicrobial-stewardship-initiative
#10
Allison A Kelly, Makoto M Jones, Kelly L Echevarria, Stephen M Kralovic, Matthew H Samore, Matthew B Goetz, Karl J Madaras-Kelly, Loretta A Simbartl, Anthony P Morreale, Melinda M Neuhauser, Gary A Roselle
OBJECTIVE To detail the activities of the Veterans Health Administration (VHA) Antimicrobial Stewardship Initiative and evaluate outcomes of the program. DESIGN Observational analysis. SETTING The VHA is a large integrated healthcare system serving approximately 6 million individuals annually at more than 140 medical facilities. METHODS Utilization of nationally developed resources, proportional distribution of antibiotics, changes in stewardship practices and patient safety measures were reported. In addition, inpatient antimicrobial use was evaluated before and after implementation of national stewardship activities...
January 25, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28110978/impact-of-the-affordable-care-act-medicaid-expansion-on-emergency-department-high-utilizers-with-ambulatory-care-sensitive-conditions-a-cross-sectional-study
#11
Daniel B Gingold, Rachelle Pierre-Mathieu, Brandon Cole, Andrew C Miller, Joneigh S Khaldun
OBJECTIVES: The effect of the Affordable Care Act on emergency department (ED) high utilizers has not yet been thoroughly studied. We sought to determine the impact of changes in insurance eligibility following the 2014 Medicaid expansion on ED utilization for ambulatory care sensitive conditions (ACSC) by high ED utilizers in an urban safety net hospital. METHODS: High utilizers were defined as patients with ≥4 visits in the 6months before their most recent visit in the study period (July-December before and after Maryland's Medicaid expansion in January 2014)...
January 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28110677/predictors-of-medical-and-mental-health-care-use-in-patients-with-irritable-bowel-syndrome-in-the-united-states
#12
Gregory D Gudleski, Nikhil Satchidanand, Laura J Dunlap, Varnita Tahiliani, Xiaohua Li, Laurie Keefer, Jeffrey M Lackner
Because health care demand among IBS patients imposes a heavy economic burden, identifying high utilizers has potential for improving quality and efficiency of care. Previous research has not identified reliable predictors of utilization of IBS patients. We sought to identify factors predictive of health care utilization among severe IBS patients. 291 IBS patients completed testing whose content mapped onto the Andersen model of health care utilization. 2-stage hurdle models were used to determine predictors of health care use (probability and frequency)...
January 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28101815/developing-a-crowdsourcing-approach-and-tool-for-pharmacovigilance-education-material-delivery
#13
Andrew Bate, Jürgen Beckmann, Alexander Dodoo, Linda Härmark, Kenneth Hartigan-Go, Anna Hegerius, Marie Lindquist, Eugène van Puijenbroek, Marco Tuccori, Ulrich Hagemann
The number of pharmacovigilance professionals worldwide is increasing with a high staff turnover. There is a constant stream of new colleagues with an interest or need to learn about the discipline. Consequently, there is an increasing need for training in pharmacovigilance. An important step towards this has been made through developing and publishing the World Health Organization (WHO)-International Society of Pharmacovigilance (ISoP) Pharmacovigilance Curriculum. Using the Pharmacovigilance Curriculum effectively, it should be supplemented by providing comprehensive training material from various sources, and making the Pharmacovigilance Curriculum attractive and a high-utility product...
January 18, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28070474/recent-trends-in-the-prevalence-of-low-dose-aspirin-use-for-primary-and-secondary-prevention-of-cardiovascular-disease-in-the-united-states-2012-2015
#14
Mark Stuntz, Brent Bernstein
Aspirin therapy has been shown to be an effective prevention measure to reduce the risk of new or recurring cardiovascular events. The aim of this study was to provide an epidemiological analysis of low-dose aspirin use for primary and secondary CVD prevention from 2012 to 2015. Estimates of self-reported low-dose aspirin use for primary and secondary CVD prevention were obtained from the National Health Interview Survey for the years 2012-2015. Temporal changes in the prevalence of aspirin use for primary and secondary CVD prevention were assessed using logistic regression...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28068954/cognitively-and-physically-demanding-exergaming-to-improve-executive-functions-of-children-with-attention-deficit-hyperactivity-disorder-a-randomised-clinical-trial
#15
Valentin Benzing, Mirko Schmidt
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common mental disorders observed in childhood and adolescence. Its key symptoms - reduced attention, poor control of impulses as well as increased motor activity - are associated with decreased executive functions performance, finally affecting academic achievement. Although drug treatments usually show some effect, alternative treatments are continually being sought, due to lack of commitment and possible side effects...
January 10, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28035775/reducing-liberal-red-blood-cell-transfusions-at-an-academic-medical-center
#16
Harry S Saag, Claudette M Lajam, Simon Jones, Nikita Lakomkin, Joseph A Bosco, Rebecca Wallack, Spiros G Frangos, Prashant Sinha, Nicole Adler, Patti Ursomanno, Leora I Horwitz, Frank M Volpicelli
BACKGROUND: Educational and computerized interventions have been shown to reduce red blood cell (RBC) transfusion rates, yet controversy remains surrounding the optimal strategy needed to achieve sustained reductions in liberal transfusions. STUDY DESIGN AND METHODS: The purpose of this study was to assess the impact of clinician decision support (CDS) along with targeted education on liberal RBC utilization to four high-utilizing service lines compared with no education to control service lines across an academic medical center...
December 30, 2016: Transfusion
https://www.readbyqxmd.com/read/27995539/use-of-electronic-resources-for-psychiatry-clerkship-learning-a-medical-student-survey
#17
Caitlin E Snow, John Torous, Janna S Gordon-Elliott, Julie B Penzner, Fermonta Meyer, Robert Boland
OBJECTIVE: The primary aim of this study is to examine medical students' use patterns, preferences, and perceptions of electronic educational resources available for psychiatry clerkship learning. METHODS: Eligible participants included medical students who had completed the psychiatry clerkship during a 24-month period. An internet-based questionnaire was used to collect information regarding the outcomes described above. RESULTS: A total of 68 medical students responded to the survey...
December 19, 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/27939174/challenges-in-the-development-of-an-m4-pam-in-vivo-tool-compound-the-discovery-of-vu0467154-and-unexpected-dmpk-profiles-of-close-analogs
#18
Michael R Wood, Meredith J Noetzel, Michael S Poslusney, Bruce J Melancon, James C Tarr, Atin Lamsal, Sichen Chang, Vincent B Luscombe, Rebecca L Weiner, Hyekyung P Cho, Michael Bubser, Carrie K Jones, Colleen M Niswender, Michael W Wood, Darren W Engers, Nicholas J Brandon, Mark E Duggan, P Jeffrey Conn, Thomas M Bridges, Craig W Lindsley
This letter describes the chemical optimization of a novel series of M4 positive allosteric modulators (PAMs) based on a 5-amino-thieno[2,3-c]pyridazine core, developed via iterative parallel synthesis, and culminating in the highly utilized rodent in vivo tool compound, VU0467154 (5). This is the first report of the optimization campaign (SAR and DMPK profiling) that led to the discovery of VU0467154, and details all of the challenges faced in allosteric modulator programs (steep SAR, species differences in PAM pharmacology and subtle structural changes affecting CNS penetration)...
January 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27913830/genome-scale-modeling-of-thermophilic-microorganisms
#19
Sanjeev Dahal, Suresh Poudel, R Adam Thompson
Thermophilic microorganisms are of increasing interest for many industries as their enzymes and metabolisms are highly efficient at elevated temperatures. However, their metabolic processes are often largely different from their mesophilic counterparts. These differences can lead to metabolic engineering strategies that are doomed to fail. Genome-scale metabolic modeling is an effective and highly utilized way to investigate cellular phenotypes and to test metabolic engineering strategies. In this review we chronicle a number of thermophilic organisms that have recently been studied with genome-scale models...
December 3, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27890750/the-use-of-social-media-communications-in-brain-aneurysms-and-subarachnoid-hemorrhage-a-mixed-method-analysis
#20
Naif M Alotaibi, Nardin Samuel, Justin Wang, Christopher S Ahuja, Daipayan Guha, George M Ibrahim, Tom A Schweizer, Gustavo Saposnik, R Loch Macdonald
BACKGROUND: The diagnosis of a ruptured or unruptured brain aneurysm has a significant impact on patients' quality of life and their psychosocial wellbeing. As a result, patients and caregivers may resort to social media platforms for support and education. The aim of this report is to evaluate the current use of social media and the online communications regarding brain aneurysms. METHODS: Three social media platforms (Facebook, Twitter and YouTube) were assessed for public content pertaining to brain aneurysms in March 2016...
November 24, 2016: World Neurosurgery
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