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https://www.readbyqxmd.com/read/27913830/genome-scale-modeling-of-thermophilic-microorganisms
#1
Sanjeev Dahal, Suresh Poudel, R Adam Thompson
Thermophilic microorganisms are of increasing interest for many industries as their enzymes and metabolisms are highly efficient at elevated temperatures. However, their metabolic processes are often largely different from their mesophilic counterparts. These differences can lead to metabolic engineering strategies that are doomed to fail. Genome-scale metabolic modeling is an effective and highly utilized way to investigate cellular phenotypes and to test metabolic engineering strategies. In this review we chronicle a number of thermophilic organisms that have recently been studied with genome-scale models...
December 3, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27890750/the-use-of-social-media-communications-in-brain-aneurysms-and-subarachnoid-hemorrhage-a-mixed-method-analysis
#2
Naif M Alotaibi, Nardin Samuel, Justin Wang, Christopher S Ahuja, Daipayan Guha, George M Ibrahim, Tom A Schweizer, Gustavo Saposnik, R Loch Macdonald
BACKGROUND: The diagnosis of a ruptured or unruptured brain aneurysm has a significant impact on patients' quality of life and their psychosocial wellbeing. As a result, patients and caregivers may resort to social media platforms for support and education. The aim of this report is to evaluate the current use of social media and the online communications regarding brain aneurysms. METHODS: Three social media platforms (Facebook, Twitter and YouTube) were assessed for public content pertaining to brain aneurysms in March 2016...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27825700/boronate-affinity-based-surface-molecularly-imprinted-polymers-using-glucose-as-fragment-template-for-excellent-recognition-of-glucosides
#3
Mijun Peng, Haiyan Xiang, Xin Hu, Shuyun Shi, Xiaoqing Chen
Rapid and efficient extraction of bioactive glycosides from complex natural origins poses a difficult challenge, and then is often inherent bottleneck for their highly utilization. Herein, we propose a strategy to fabricate boronate affinity based surface molecularly imprinted polymers (MIPs) for excellent recognition of glucosides. d-glucose was used as fragment template. Boronic acid, dynamic covalent binding with d-glucose under different pH conditions, was selected as functional monomer to improve specificity...
October 25, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27824190/biomass-lysine-derived-nitrogen-doped-carbon-hollow-cubes-via-a-nacl-crystal-template-an-efficient-bifunctional-electrocatalyst-for-oxygen-reduction-and-evolution-reactions
#4
Xiangjun Zheng, Xuecheng Cao, Xiaowei Li, Jinghua Tian, Chao Jin, Ruizhi Yang
Nitrogen-doped carbon hollow cubes (NCHCs) are fabricated from biomass l-lysine monohydrochloride via a facile and low-cost NaCl template process, showing efficient bifunctional electrocatalytic activities towards the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The resultant lysine-derived carbon hollow cubes with hierarchical pores on the wall are conducive to mass transport and high utilization of nitrogen dopant-induced active sites during the electrocatalytic process. When used as electrocatalysts for the ORR, an onset potential of 0...
November 8, 2016: Nanoscale
https://www.readbyqxmd.com/read/27800600/cholestyramine-as-a-promising-strong-anion-exchange-resin-for-direct-capture-of-genetic-biomarkers-from-raw-pancreatic-fluids
#5
Andrew J Hilmer, R Brooke Jeffrey, Walter G Park, Chaitan Khosla
The ability to capture cell-free DNA from the gastrointestinal tract, in a minimally invasive manner, could enhance our ability to diagnose gastrointestinal disease, or gain a better understanding of the spatial mapping of the intestinal microbiota. We therefore sought to identify a class of capture agents that could directly and efficiently sequester genetic material from intestinal fluids. As a particular case study, we examined the ability to capture DNA from pancreatic secretions, for potential application in enabling the sequestration of early, genetic biomarkers of pancreatic disease...
November 1, 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/27774384/janus-separator-of-polypropylene-supported-cellular-graphene-framework-for-sulfur-cathodes-with-high-utilization-in-lithium-sulfur-batteries
#6
Hong-Jie Peng, Dai-Wei Wang, Jia-Qi Huang, Xin-Bing Cheng, Zhe Yuan, Fei Wei, Qiang Zhang
Owing to the conversion chemistry of the sulfur cathode, the lithium-sulfur (Li-S) batteries exhibit high theoretical energy density. However, the intrinsic mobile redox centers during the sulfur/Li2S-to-lithium polysulfides solid-to-liquid phase transition induce low sulfur utilization and poor cycling life. Herein, the Janus separator of mesoporous cellular graphene framework (CGF)/polypropylene membrane to promote the utilization of sulfur cathode is introduced. The porous polypropylene membrane serves as an insulating substrate in contact with lithium anode while CGFs that possess high electrical conductivity of 100 S cm(-1), a large mesopore volume of 3...
January 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27758090/the-rise-and-future-of-glyphosate-and-glyphosate-resistant-crops
#7
Jerry M Green
Glyphosate and glyphosate-resistant crops had a revolutionary impact on weed management practices, but the epidemic of glyphosate-resistant (GR) weeds is rapidly decreasing the value of these technologies. In areas that fully adopted glyphosate and GR crops, GR weeds evolved and glyphosate and glyphosate traits now must be combined with other technologies. The chemical company solution is to combine glyphosate with other chemicals, and the seed company solution is to combine glyphosate resistance with other traits...
October 18, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27735930/prenatal-visit-utilization-and-outcomes-in-pregnant-women-with-type-ii-and-gestational-diabetes
#8
E B Carter, M G Tuuli, A O Odibo, G A Macones, A G Cahill
OBJECTIVE: To investigate the association between the number of prenatal visits (PNVs) and pregnancy outcomes in women with gestational diabetes (GDM) and Type 2 diabetes mellitus (DM). STUDY DESIGN: A 4-year prospective cohort study of women with GDM and DM and was conducted. Patients ⩾75th percentile for number of PNVs were compared with those ⩽25th percentile. The primary outcomes were large for gestational age (LGA) with birth weight >90% and neonatal intensive care unit (NICU) admission for >24 h...
October 13, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27733138/a-qualitative-study-on-factors-that-influence-women-s-choice-of-delivery-in-health-facilities-in-addis-ababa-ethiopia
#9
Tigest Shifraw, Yemane Berhane, Hanna Gulema, Tamil Kendall, Anne Austin
BACKGROUND: Facility based delivery for mothers is one of the proven interventions to reduce maternal and neonatal morbidity and mortality. This study identified women's reasons for seeking to give birth in a health facility and captured their perceptions of the quality of care they received during their most recent birth, in a population with high utilization of facility based deliveries. METHODS: This qualitative study was conducted in eight health centers in Addis Ababa...
October 12, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27723317/selenocysteine-as-a-latent-bioorthogonal-electrophilic-probe-for-deubiquitylating-enzymes
#10
Samuel D Whedon, Nagula Markandeya, Ambar S J B Rana, Caroline E Weller, Nicholas A Senger, Frantisek Turecek, Eric R Strieter, Champak Chatterjee
Deubiquitylating enzymes (DUBs) remove ubiquitin (Ub) from various cellular proteins and render eukaryotic ubiquitylation a dynamic process. The misregulation of protein ubiquitylation is associated with many human diseases, and there is an urgent need to identify specific DUBs associated with therapeutically relevant targets of Ub. We report the development of two facile selenocysteine-based strategies to generate the DUB probe dehydroalanine (Dha). Optimized oxidative or alkylative elimination of Se yielded Dha at the C-terminus of Ub...
October 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27720381/borrelia-burgdorferi-dna-absent-multiple-rickettsia-spp-dna-present-in-ticks-collected-from-a-teaching-forest-in-north-central-florida
#11
Katherine Sayler, Jessica Rowland, Carisa Boyce, Emma Weeks
Tick-borne diseases are an emerging public health threat in the United States. In Florida, there has been public attention directed towards the possibility of locally acquired Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, in association with the lone star tick. The aim of this study was to determine the prevalence of ticks and the pathogens they carry and potentially transmit, such as B. burgdorferi, in a highly utilized teaching and research forest in North Central Florida. Ticks were collected by dragging and flagging methods over a four month period in early 2014, identified, and tested by PCR for multiple pathogens including Anaplasma, Borrelia, Rickettsia, and Ehrlichia species...
January 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27712896/choroid-detachment-a-rare-cause-of-vision-loss-diagnosed-by-point-of-care-ultrasound
#12
Brian Jarrett, Michael Secko
BACKGROUND: Choroid detachment is a rare disease process that has a multitude of etiologies; usually related to recent ophthalmological surgery, eye trauma, corneal ulcers, or intraocular pressure-lowering agents. Point-of-care ocular ultrasound has high utility and accuracy in diagnosing pathology of the eye. CASE REPORT: We present a case of a patient who presented with vision loss caused by a choroid detachment diagnosed on point-of-care ultrasound because fundoscopic examination was limited due to cataracts...
October 3, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27700621/use-of-visual-range-measurements-to-predict-pm2-5-exposures-in-southwest-asia-and-afghanistan
#13
Shahir Masri, Eric Garshick, Jaime Hart, Walid Bouhamra, Petros Koutrakis
Implication Statement This study demonstrates the ability to use airport visibility to estimate PM2.5 concentrations in Southwest Asian and Afghanistan. This supports the use of historical and ongoing visibility data to estimate PM2.5 exposure in this region of the world, where PM exposure information is otherwise scarce. This is of high utility to epidemiologists investigating the relationship between chronic exposure to PM2.5 and respiratory diseases among deployed military personnel stationed at various military bases throughout the region...
October 4, 2016: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/27677560/comparison-of-emergency-department-wait-times-in-adults-with-sickle-cell-disease-versus-other-painful-etiologies
#14
Dianne Pulte, Paris B Lovett, David Axelrod, Albert Crawford, John McAna, Rhea Powell
Sickle cell disease is characterized by intermittent painful crises often requiring treatment in the emergency department (ED). Past examinations of time-to-provider (TTP) in the ED for patients with sickle cell disease demonstrated that these patients may have longer TTP than other patients. Here, we examine TTP for patients presenting for emergency care at a single institution, comparing patients with sickle cell disease to both the general population and to those with other painful conditions, with examination of both institutional and patient factors that might affect wait times...
September 28, 2016: Hemoglobin
https://www.readbyqxmd.com/read/27640612/the-home-team-evaluating-the-effect-of-an-ems-based-outreach-team-to-decrease-the-frequency-of-911-use-among-high-utilizers-of-ems
#15
Niels Tangherlini, Julian Villar, John Brown, Robert M Rodriguez, Clement Yeh, Benjamin T Friedman, Paul Wada
OBJECTIVES: The San Francisco Fire Department's (SFFD; San Francisco, California USA) Homeless Outreach and Medical Emergency (HOME) Team is the United States' first Emergency Medical Services (EMS)-based outreach effort using a specially trained paramedic to redirect frequent users of EMS to other types of services. The effectiveness of this program at reducing repeat use of emergency services during the first seven months of the team's existence was examined. METHODS: A retrospective analysis of EMS use frequency and demographic characteristics of frequent users was conducted...
December 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27623540/perspectives-on-root-causes-of-high-utilization-that-extend-beyond-the-patient
#16
Lauran Hardin, Adam Kilian, Michael Olgren
No abstract text is available yet for this article.
September 13, 2016: Population Health Management
https://www.readbyqxmd.com/read/27613732/factors-associated-with-repeated-health-resource-utilization-in-patients-with-diverticulitis
#17
Steven N Mathews, Ryan Lamm, Jie Yang, Lijuan Kang, Dana Telem, Aurora D Pryor, Mark Talamini, Jill Genua
Conservative management trends in diverticulitis may lead to increased hospitalizations secondary to repeated attacks. The study aimed to characterize trends in management and risk-assess patients with diverticulitis that required multiple admissions to identify high utilizers. A total of 265,724 patients with diverticulitis were identified from 1995 to 2014 from the New York SPARCS database. Patients with ≥2 hospital admissions were stratified across demographics, comorbidities, insurance status, and surgical intervention...
September 9, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27612010/tumour-and-normal-tissue-radiobiology-in-mouse-models-how-close-are-mice-to-mini-humans
#18
Bridget F Koontz, Frank Verhaegen, Dirk De Ruysscher
Animal modelling is essential to the study of radiobiology and the advancement of clinical radiation oncology by providing preclinical data. Mouse models in particular, have been highly utilized in the study of both tumour and normal tissue radiobiology because of their cost effectiveness and versatility. Technology has significantly advanced in preclinical radiation techniques to allow highly conformal image guided irradiation of small animals in an effort to mimic human treatment capabilities. However, the biological and physical limitations of animal modelling should be recognized and considered when interpreting preclinical radiotherapy studies...
September 9, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27607309/variation-in-the-utilization-of-minimally-invasive-surgical-operations
#19
Lindsay E Kuo, Kenric Murayama, Kristina D Simmons, Rachel R Kelz
OBJECTIVE: The goal of this study was to examine regional variation in use of minimally invasive surgical (MIS) operations. SUMMARY BACKGROUND DATA: Regional variation exists in performance of surgical operations. Variation in the use of MIS has not been studied. METHODS: Five operations that are performed open or MIS were selected: cholecystectomy, appendectomy, colectomy, antireflux, and bariatric. A 3-state database from 2008 to 2011 was used; states were divided into hospital service areas (HSAs)...
March 11, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27605957/on-the-way-to-universal-coverage-of-maternal-services-in-iringa-rural-district-in-tanzania-who-is-yet-to-be-reached
#20
Manuela Straneo, Piera Fogliati, Ingrid Pellis, Catherine Goodman, Donata Dalla Riva, Firma Kisika, Ezekiel Mpuya, Giovanni Putoto
BACKGROUND: Strategies to tackle maternal mortality in sub-Saharan Africa include expanding coverage of reproductive services. Even where high, more vulnerable women may not access services. No data is available on high coverage determinants. We investigated this in Tanzania in a predicted high utilization area. METHODS: Data was collected through a household survey of 464 women with a recent delivery. Primary outcomes were facility delivery and ≥4 ANC visits...
June 2016: African Health Sciences
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