Qian Zhou, Fay Y Womer, Lingtao Kong, Feng Wu, Xiaowei Jiang, Yifang Zhou, Dahai Wang, Chuan Bai, Miao Chang, Guoguang Fan, Ke Xu, Yong He, Yanqing Tang, Fei Wang
BACKGROUND: Bipolar disorder is a systemic brain disorder. Accumulated evidence suggested that cortical-subcortical imbalance could be a trait-related pathogenic factor of bipolar disorder. Degree centrality, a robust index of focal connectivity in which the number of direct connections from one node to all nodes is counted, has not previously been studied in bipolar disorder as a whole. METHODS: Resting state functional magnetic resonance imaging was performed on 52 patients with DSM-IV bipolar I disorder and 70 healthy controls recruited between September 2009 and July 2014...
May 2017: Journal of Clinical Psychiatry