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https://www.readbyqxmd.com/read/28635408/assisted-reproductive-technologies-and-the-iranian-community-attitude-towards-infertility
#1
Aliyar Ahmadi, Sara Bamdad
Since the late 1990s, assisted reproductive technologies (ARTs) have been legitimized in Iran through an official religious endorsement. Iran, under the dominant authority of the Shia sect, is now the most enthusiastic adopter of ARTs in the Muslim world, permitting all forms of treatments, including third party donation. This study examined the public perception of assisted conception and its influence on the adoption of these methods in Iran. The study was questionnaire-based and conducted in 2012 in Shiraz, the most populated city in the south of Iran...
February 7, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28632498/can-early-ultrasonography-explain-the-lower-miscarriage-rates-in-twin-as-compared-to-singleton-pregnancies-following-assisted-reproduction
#2
Ana Póvoa, Alexandra Matias, Pedro Xavier, Isaac Blickstein
OBJECTIVE: To compare first trimester 2D conventional and 3D power Doppler angiography measures in twins and singletons following assisted reproduction. METHODS: We prospectively evaluated 50 singleton and 47 twin pregnancies that eventually ended in live births. Patients were recruited from a single assisted reproductive technology (ART) center with standard treatment protocols. Obstetric ultrasound was performed at 8-9 weeks +6 days. Intervillous flow, uteroplacental circulation and uterine artery pulsatility (PI) and resistance index (RI) using two-dimensional (2D) ultrasound examination were evaluated...
June 20, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28629925/a-50-reduction-in-multiple-live-birth-rate-is-associated-with-a-13-cost-saving-a-real-life-retrospective-cost-analysis
#3
Karen Peeraer, Thomas M D'Hooghe, Cindy Vandoren, Jeroen Trybou, Carl Spiessens, Sophie Debrock, Diane De Neubourg
Belgian legislation limiting the number of embryos for transfer has been shown to result in a 50% reduction of the multiple live birth rate (MLBR) per cycle without having a negative impact on the cumulative delivery rate per patient within six cycles or 36 months. The objective of the current study was to evaluate the cost saving associated with a 50% reduction in MLBR. A retrospective cost analysis was performed of 213 couples, who became pregnant and had a live birth after one or more assisted reproductive technology treatment cycles, and their 254 children...
June 5, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28624766/dhea-protects-mitochondria-against-dual-modes-of-apoptosis-and-necroptosis-in-human-granulosa-ho23-cells
#4
Kuan-Hao Tsui, Peng-Hui Wang, Li-Te Lin, Chia-Jung Li
Because ovarian granulosa cells are essential for oocyte maturation and development, we validated human granulosa HO23 cells to evaluate the ability of the DHEA to prevent cell death after starvation. The present study was aimed to investigate whether DHEA could protect against starvation-induced apoptosis and necroptosis in human oocyte granulosa HO23 cells. The starvation was induced by treatment of serum-free (SF) medium for 4 h in vitro Starvation-induced mitochondrial depolarization, cytochrome c release and caspase-3 activation were largely prevented by DHEA in HO23 cells...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28621618/placental-imprinting-variation-associated-with-assisted-reproductive-technologies-and-subfertility
#5
Julia F Litzky, Maya A Deyssenroth, Todd M Everson, David A Armstrong, Luca Lambertini, Jia Chen, Carmen J Marsit
Infertility affects one in six couples in developed nations, resulting in an increasing use of assisted reproductive technologies (ART). Both ART and subfertility appear to be linked to lower birth weight outcomes, setting infants up for poor long-term health. Prenatal growth is, in part, regulated via epigenetically controlled imprinted genes in the placenta. Although differences in DNA methylation between ART and control infants have been found, it remains unclear whether these differences are due to the ART procedures or to the underlying parental subfertility and how these methylation differences affect imprinted gene expression...
June 16, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28621049/lower-foxo3-mrna-expression-in-granulosa-cells-is-involved-in-unexplained-infertility
#6
Hikaru Yamamoto, Yoshiki Yamashita, Natsuho Saito, Atsushi Hayashi, Masami Hayashi, Yoshito Terai, Masahide Ohmichi
AIM: The aim of this study was to investigate whether FOXO1 and FOXO3 mRNA expression in granulosa cells is the cause of unexplained infertility. METHODS: Thirty-one patients aged <40 years (13 with unexplained infertility and 18 with male partner infertility as a control group) whose serum anti-Müllerian hormone level was >0.5 ng/μL were enrolled in the study. All patients underwent oocyte retrieval under a short protocol from June 2012 to October 2013...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28620352/efficacy-of-follicle-stimulating-hormone-fsh-alone-fsh%C3%A2-%C3%A2-luteinizing-hormone-human-menopausal-gonadotropin-or-fsh%C3%A2-%C3%A2-human-chorionic-gonadotropin-on-assisted-reproductive-technology-outcomes-in-the-personalized-medicine-era-a-meta-analysis
#7
Daniele Santi, Livio Casarini, Carlo Alviggi, Manuela Simoni
SETTING: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) act on the same receptor, activating different signal transduction pathways. The role of LH or hCG addition to follicle-stimulating hormone (FSH) as well as menopausal gonadotropins (human menopausal gonadotropin; hMG) in controlled ovarian stimulation (COS) is debated. OBJECTIVE: To compare FSH + LH, or FSH + hCG or hMG vs. FSH alone on COS outcomes. DESIGN: A meta-analysis according to PRISMA statement and Cochrane Collaboration was performed, including prospective, controlled clinical trials published until July 2016, enrolling women treated with FSH alone or combined with other gonadotropins...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28612975/the-effect-of-endometrial-scratch-injury-on-pregnancy-outcome-in-women-with-previous-intrauterine-insemination-failure-a-randomized-clinical-trial
#8
Mahnaz Ashrafi, Ensieh Shahrokh Tehraninejad, Mansooreh Haghiri, Masoumeh Masomi, Shahideh Jahanian Sadatmahalleh, Arezoo Arabipoor
AIM: Endometrial scratch injury (ESI) has been recently proposed to enhance the implantation rate in assisted reproductive technology cycles. The present study was conducted to determine the effect of ESI on pregnancy rate in women with intrauterine insemination (IUI) failure. METHODS: This prospective randomized controlled study was carried out in Imam-Khomeini Hospital and Royan Institute, Tehran, during a 12-month period from January 2013 to January 2014. After assessment, 169 patients who had IUI failure twice or more (no chemical or clinical pregnancy) with normal uterine anatomy and hysterosalpingography, were enrolled...
June 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28609806/what-do-infertile-women-think-about-oocyte-reception-oocyte-donation-and-child-adoption
#9
Juliana Straehl, Lúcia Alves da Silva Lara, Marcos Felipe Silva de Sá, Rosana Maria Reis, Ana Carolina Japur de Sá Rosa-E-Silva
Purpose The views of infertile couples regarding oocyte donation by third parties and adoption are unknown, as these may be interpreted as a final closure of the available options for conception. This study aimed to determine the acceptance of oocyte donation, oocyte reception, and child adoption of infertile women who submitted to assisted reproductive technology (ART) treatment Methods Sixty-nine women who were under treatment for infertility and submitted to ART procedures were included in this cross-sectional study...
June 13, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28609278/do-women-offered-assisted-reproduction-technologies-have-a-higher-incidence-of-gynecologic-cancer-a-systematic-review-and-meta-analysis
#10
REVIEW
Juan Enrique Schwarze, Paulina Valdebenito, Carolina Ortega, Sonia Villa, Javier Crosby, Ricardo Pommer
The last two decades have seen an increase in the number of women diagnosed with infertility. The consequent growth in the use of assisted reproductive technologies (ART) calls for the determination of its long-term effects, including the risk of cancer. Many studies have attempted to answer this question, albeit with contradictory results. This review aimed to assess whether assisted reproductive technologies are associated with an increased risk of gynecological cancer. A search for papers in the literature was carried out on MEDLINE, TRIP DATABASE and NICE, resulting in 11 studies enrolling 3,900,231 patients altogether...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28609272/outcome-of-assisted-reproductive-technology-in-overweight-and-obese-women
#11
Antonio MacKenna, Juan Enrique Schwarze, Javier A Crosby, Fernando Zegers-Hochschild
OBJECTIVE: The main objective of this study was to assess the prevalence of overweight and obesity among patients undergoing assisted reproductive technology (ART) in Latin America and its consequences on treatment outcomes. METHODS: We used the Latin American Registry of ART to obtain women's age and body mass index (BMI), cancellation rate, number of oocytes retrieved and embryos transferred, clinical pregnancy, live birth and miscarriage rates from 107.313 patients undergoing autologous IVF and ICSI during four years; a multivariable analysis was performed to determine the effect of BMI on cancellation, oocytes retrieved, pregnancy, live birth and miscarriage, adjusting for age, number of embryos transferred and embryo developmental stage upon embryo transfer, when appropriate...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28609270/a-prospective-study-comparing-two-embryo-transfer-soft-catheters
#12
Emily De Conto, Artur K Schuster, Vanessa K Genro, Rita Chapon, Daniela S da Silva, João Sabino Cunha-Filho
OBJECTIVES: To compare reproductive outcomes using two different soft catheters i.e. Set TDT® and Cook® Sydney IVF. The primary outcome was defined as a positive β-human chorionic gonadotropin (β-hCG) test. METHODS: Our prospective study recruited 68 patients undergoing in vitro fertilization cycles in a private fertility clinic in Porto Alegre, Brazil, between January 2014 and April 2016. They were divided into two groups according to the catheter that would be used for the embryo transfer, and the groups were matched by age...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28606231/-nkx2-5-and-tbx5-gene-mutations-in-in-vitro-fertilization-children-with-congenital-heart-disease
#13
Jing-Hui Yang, Xiao-Yan Xu, Hong-Ying Mi, Yan Jiang, Xin-Mei Ma, Li Li
OBJECTIVE: To explore the differences of NKX2.5 and TBX5 gene mutations between in vitro fertilization (IVF) children with congenital heart disease (CHD) and naturally conceived children with CHD. METHODS: Blood samples from 68 IVF children with CHD and 98 naturally conceived children with CHD were collected. The mutations in coding regions 1 and 2 of the NKX2.5 gene, and coding regions 4, 5, and 8 of the TBX5 gene were examined by polymerase chain reaction (PCR) and DNA sequencing...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28606230/-a-survey-of-pubertal-development-in-children-born-with-assisted-reproductive-technology
#14
Zi-Yuan Liu, Xin-Li Wang, Tong-Yan Han, Yun-Pu Cui, Xue-Mei Wang, Xiao-Mei Tong, Yi Song, Hai-Jun Wang, Song Li
OBJECTIVE: To investigate the status of pubertal development in children born with assisted reproductive technology (ART). METHODS: A retrospective analysis was performed on the pubertal development data of children born with ART in Peking University Third Hospital from 1994 to 2003 (ART group). The data in the cross-sectional study "Reports on the Physical Fitness and Health Research of Chinese School Students in 2010" were used as a control. The age at menarche and the age at spermarche were compared between the two groups...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28602789/age-associated-and-deslorelin-induced-declines-in-serum-anti-m%C3%A3-llerian-hormone-concentrations-in-female-cheetahs-acinonyx-jubatus
#15
Ned J Place, Adrienne E Crosier, Pierre Comizzoli, Jennifer B Nagashima, Holly Haefele, Anne Schmidt-Küntzel, Laurie L Marker
Anti-Müllerian hormone (AMH) is widely used in human medicine to non-invasively estimate the size of the ovarian follicle reserve and to predict the ovarian response to gonadotropin stimulation in the context of assisted reproductive technologies (e.g., IVF). These applications of AMH testing have recently expanded to non-human mammals, with production animals, such as cows, goats and sheep being the primary focus of AMH research. However, few investigations have involved exotic species, and in particular carnivores...
June 8, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28600105/ovarian-stimulation-and-risk-of-breast-cancer-in-swedish-women
#16
Frida E Lundberg, Anastasia N Iliadou, Kenny Rodriguez-Wallberg, Christina Bergh, Kristina Gemzell-Danielsson, Anna L V Johansson
OBJECTIVE: To investigate whether ovarian stimulation for treating infertility is associated with the risk of breast cancer. DESIGN: Nationwide register-based cohort study. SETTING: Not applicable. PATIENT(S): In a cohort of 1,340,211 women who gave birth 1982-2012, we investigated the relationship between assisted reproductive technology (ART) and incidence of breast cancer. Associations between any ovarian stimulation since 2005 and breast cancer incidence were studied in a separate cohort of 1,877,140 women born 1960-92...
June 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28595591/effect-of-race-and-ethnicity-on-utilization-and-outcomes-of-assisted-reproductive-technology-in-the-usa
#17
Alice J Shapiro, Sarah K Darmon, David H Barad, David F Albertini, Norbert Gleicher, Vitaly A Kushnir
BACKGROUND: The purpose of this study was to determine the utilization and live birth rates of assisted reproductive technology (ART) modalities among various racial and ethnic groups in recent years. METHODS: We reviewed ART data reported to the Society for Assisted Reproductive Technologies Clinic Outcome Reporting System (SART CORS) for autologous ART and third-party ART (3ART) cycles which involved donor oocytes, sperm, embryos and gestational carrier, performed in the U...
June 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28594091/contingent-maternities-maternal-claims-making-in-third-party-reproduction
#18
Katherine M Johnson
The new reproductive technologies have significantly impacted definitions of motherhood. Historically, mothers were defined through the act of giving birth, but egg donation, embryo donation, and surrogacy disrupt this. Now multiple women can potentially claim maternity through gestational, genetic, legal, and social ties. Although there is some legal precedent for designating parentage, there is no simple solution to identify the 'true' mother. I address maternal claims-making in third party reproduction via a content analysis of US patient literature for infertile women...
June 8, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28592340/influence-of-gonadotropins-on-ovarian-follicle-growth-and-development-in-vivo-and-in-vitro
#19
Maxim Filatov, Yulia Khramova, Elena Parshina, Tatiana Bagaeva, Maria Semenova
Gonadotropins are the key regulators of ovarian follicles development. They are applied in therapeutic practice in assisted reproductive technology clinics. In the present review we discuss the basic gonadotropic hormones - recombinant human follicle-stimulating hormone, its derivatives, luteinizing hormone and gonadotropin serum of pregnant mares, their origin, and application in ovarian follicle systems in in vitro culture systems.
June 8, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28589740/a-survey-of-scientists-awareness-of-and-attitudes-to-the-use-of-human-blood-products-and-alternatives-in-human-assisted-reproductive-technology
#20
Kelli Peirce, Peter Roberts, Jaffar Ali, Jacqui Coombes, Phillip Matson
Scientists working in assisted reproduction [members of Scientists in Reproductive Technology (SIRT) Australia, and subscribers of the online forums EmbryoMail and Quartec] were invited to complete an online questionnaire on the use of human blood products in assisted reproductive technologies (ART). A total of 260 started the questionnaire, with 208 (80%) completing it. A total of 62% of respondents had worked in human ART ≥8 years and 68% had post-graduate qualifications. The majority (82%) reported using products of animal or human origin, with 75% knowing why protein was added to culture media and 41% not worried by this...
June 7, 2017: Human Fertility: Journal of the British Fertility Society
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