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https://www.readbyqxmd.com/read/27920521/celastrol-nanomicelles-attenuate-cytokine-secretion-in-macrophages-and-inhibit-macrophage-induced-corneal-neovascularization-in-rats
#1
Zhanrong Li, Jingguo Li, Lei Zhu, Ying Zhang, Junjie Zhang, Lin Yao, Dan Liang, Liya Wang
The aim of the present study was to investigate the inhibitory effects of celastrol-loaded nanomicelles (CNMs) on activated macrophage-induced corneal neovascularization (CNV) in rats and cytokine secretion in macrophages. Using an angiogenesis assay in vitro, we detected the effects of CNMs on human umbilical vein endothelial cell (HUVEC) migration and invasion. In addition, the expression levels of cytokines secreted from hypoxia-induced macrophages were assessed through cytokine array analysis. The expression of hypoxia-inducible factors-1α (HIF-1α), nuclear factor-kappa B p65 (NF-κB p65), phospho-nuclear factor-kappa B p65 (phospho-NF-κB p65), p38 mitogen-activated protein kinase (p38 MAPK), phospho-p38 MAPK, extracellular signal-regulated kinase 1/2 (ERK1/2), and phospho-ERK1/2 was analyzed by western blotting...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27904815/pneumorrhachis-resulting-in-transient-paresis-after-picc-line-insertion-into-the-ascending-lumbar-vein
#2
Russell Payne, Emily P Sieg, Arabinda Choudhary, Mark Iantosca
Obtaining intravascular access in the neonatal intensive care unit (NICU) is not only critical but also technically challenging. Malposition of the catheter tip is a known and well-documented complication. Specifically, peripherally inserted central venous catheter (PICC) line insertion into the ascending lumbar vein can lead to neurological dysfunction and, in some cases, even death. We present the first reported case of pneumorrhachis (PR) following PICC line insertion into the ascending lumbar vein. Our patient presented with lower extremity weakness and imaging confirmed the presence of air within the spinal canal...
October 17, 2016: Curēus
https://www.readbyqxmd.com/read/27853815/anatomical-variations-of-the-venous-drainage-from-the-left-adrenal-gland-an-anatomical-study
#3
Matthieu Siebert, Yohann Robert, Romain Didier, Antonin Minster, Wassila M'sallaoui, Alexandre Bellier, Philippe C J Chaffanjon
BACKGROUND: For radiologists, the venous drainage of adrenal glands is a key to the technique of selective adrenal venous sampling. For endocrine surgeons, it is key to adrenalectomy for carcinoma and pheochromocytoma. This study aims to demonstrate direct anastomosis between the left adrenal vein, the diaphragmatic circulation and the azygos system. Anatomical textbooks only offer very little information concerning the left adrenal vein (LAV) and its potential anastomosis with the reno-lumbo-azygo trunk (RLAT) and the diaphragmatic circulation...
November 16, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27853341/effect-of-the-wide-spread-use-of-endovenous-laser-ablation-on-the-treatment-of-varicose-veins-in-japan-a-large-scale-single-institute-study
#4
Masatoshi Jibiki, Tetsuro Miyata, Sachiko Futatsugi, Mitsumasa Iso, Yasutaka Sakanushi
Background and aims: In Japan, stripping under general anesthesia, lumbar anesthesia and tumescent local anesthesia has been used in the treatment of primary varicose veins due to saphenous vein insufficiency. However endovenous laser ablation (EVLA) using a 980 nm diode laser has received National Health Insurance (NHI) coverage in 2011, while EVLA using a 1470 nm diode laser with a radial 2-ring fiber has received coverage in 2014. As a result, the use of EVLA has become widespread in Japan. We herein report on the results of varicose veins treatment at our hospital...
October 1, 2016: Laser Therapy
https://www.readbyqxmd.com/read/27822948/delayed-high-output-heart-failure-due-to-arteriovenous-fistula-complicated-with-herniated-disc-surgery
#5
Taeshik Park, Sang Ho Park, Alok Arora
A 36-year-old male presented with progressive exertional dyspnea over months. Physical examination showed jugular venous distension, lung crecipitations, femoral bruit and pitting pedal edema. Echocardiogram showed a dilated right ventricle with severe pulmonary hypertension and a non collapsing inferior vena cava (IVC). On right heart catheterization, IVC oxygen saturation was noted at 92% suggesting arterial mixing; a computed tomography of the abdomen showed a fistula between the right common iliac artery to the right common iliac vein at L4 level and a massive IVC; this was linked to trauma from a disectomy done 16 years ago at L4-L5 level...
December 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27814888/dynamic-contrast-enhanced-magnetic-resonance-angiography-for-the-localization-of-spinal-dural-arteriovenous-fistulas-at-3t
#6
G Zhou, M H Li, C Lu, Y L Yin, Y Q Zhu, X E Wei, H T Lu, Q Q Zheng, W W Gao
OBJECTIVE: This study was undertaken to evaluate the accuracy of dynamic contrast-enhanced magnetic resonance angiography (DCE-MRA) in the precise location and demonstration of fistulous points in spinal dural arteriovenous fistulas (SDAVFs). METHODS: Fifteen patients (14 men, 1 woman; age range: 40-78 years; mean: 55.5 years) harboring SDAVF who underwent preoperative DCE-MRA and spinal digital subtraction angiography (DSA) between January 2012 and January 2015 were evaluated retrospectively...
November 1, 2016: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/27813034/-horner-syndrome-following-combined-spinal-epidural-anesthesia
#7
Ömer Karaca, Sezen Kumaş Solak, Serdar Demirgan, Mehmet Bademci
Horner syndrome is rarely observed in connection with epidural anesthesia. It is characterized by ptosis, enophthalmos, miosis, anisocoria, and conjunctival hyperemia in the affected eye, as well as anhydrosis and flushing on the affected side of the face. It is usually a complication spontaneously resolved without permanent neurological deficits. Intraoral anesthesia; stellate ganglion, cervical or brachial plexus blocks; thoracic, lumbar or caudal epidural anesthesia, and intrapleural analgesia are the main causes for Horner syndrome related to anesthesia...
July 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/27790323/efficacy-of-tachosil-a-fibrin-based-hemostat-for-anterior-lumbar-spine-surgery
#8
Jo Watanabe, Seiji Ohtori, Sumihisa Orita, Kazuyo Yamauchi, Yawara Eguchi, Yasuchika Aoki, Junichi Nakamura, Miyako Suzuki, Kazuhide Inage, Jun Sato, Yasuhiro Shiga, Koki Abe, Kazuki Fujimoto, Hirohito Kanamoto, Eiji Hanaoka, Kazuhisa Takahashi
STUDY DESIGN: Retrospective case series. PURPOSE: To examine the efficacy of TachoSil for vessel injury in 6 patients who underwent anterior lumbar fusion surgery (ALF). OVERVIEW OF LITERATURE: ALF for the lumbar spine has a high rate of success, although intraoperative concerns and iatrogenic complications are known, and injury of a major vessel is sometimes a complication. The efficacy of TachoSil, a fibrin-based hemostat, has been reported for several types of surgery; however, use of TachoSil for ALF surgery has not been described...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27766176/one-step-posterior-and-anterior-combined-approach-for-l5-retroperitoneal-schwannoma-eroding-a-lumbar-vertebra
#9
Giancarlo D'Andrea, Giovanni Sessa, Veronica Picotti, Antonino Raco
We report the case of a large lumbar schwannoma eroding the vertebra and originating from spinal canal with invasion of the retroperitoneal space. We also review all the cases in literature reporting lumbar schwannomas eroding the vertebral bodies and invading the retroperitoneal space focusing on the surgical strategies to manage them. Spinal CT-scan revealed a 44 mm × 55 mm inhomogeneous soft-tissue mass arising from the right L5-S1 neural foramen and its most anterior portion had a clear colliquative aspect...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27734797/deep-vein-thrombosis-of-the-lower-limb-secondary-to-lumbar-discal-hernia-compression-a-rarity-review-of-the-literature
#10
P Di Cello, S Izzo, F Pugliese, I Di Poce, A Orsini, L Izzo, G Mazzone, F Biancucci, G Sinaimeri, S Valabrega, M Almansour, P Izzo
This case report is about a 70-years-old female patient, suffering from discal hernia, with compression of the iliac vein, that led to the formation of deep vein thrombosis of the lower limbs. The angio-CT scan revealed the starting point of the L4- L5 compression where a voluminous discal hernia caused deep vein thrombosis, with the involvement the femoro-popliteal venous axis. Blood samples and PET-CT scans excluded other possible etiologic factors. This case demonstrates how a voluminous discal hernia can cause venous thrombosis...
May 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/27661564/anatomical-differences-in-patients-with-lumbosacral-transitional-vertebrae-and-implications-for-minimally-invasive-spine-surgery
#11
Darnell T Josiah, SoHyun Boo, Abdul Tarabishy, Sanjay Bhatia
OBJECTIVE The objective of this study was to investigate the neurovascular and anatomical differences in patients with lumbosacral transitional vertebrae (LSTV) and the associated risk of neurovascular injury in minimally invasive spine surgery. METHODS The authors performed a retrospective study of CT and MR images of the lumbar spine obtained at their institution between 2010 and 2014. The following characteristics were evaluated: level of the iliac crest in relation to the L4-5 disc space, union level of the iliac veins and arteries in relation to the L4-5 disc space, distribution of the iliac veins and inferior vena cava according to the different Moro zones (A, I, II, III, IV, P) at the L4-5 disc space, and the location of the psoas muscle at the L4-5 disc space...
September 23, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27659814/the-application-of-a-compact-hd-exoscope-for-illumination-and-magnification-in-high-precision-surgical-procedures
#12
Kartik G Krishnan, Karsten Schöller, Eberhard Uhl
BACKGROUND: The basic necessities for surgical procedures are illumination, exposure and magnification. These have undergone transformation in par with technology. One of the recent developments is the compact magnifying exoscope system. In this report we describe the application of this system for surgical operations and discuss its advantages and pitfalls. METHODS: We used the ViTOM(®) exoscope mounted on the mechanical holding arm. The following surgical procedures were conducted: lumbar and cervical spinal canal decompression (n=5); laminotomy and removal of lumbar migrated disc herniations (n=4); anterior cervical discectomy and fusion (n=1); removal of intraneural schwannomas (n=2); removal of a acute cerebellar hemorrhage (n=1); removal of a parafalcine atypical cerebral hematoma caused by a dural arterio-venous fistula (n=1); microsutures and anastomoses of a nerve (n=1), an artery (n=1) and veins (n=2)...
September 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27637163/induced-wedge-technique-to-improve-liquid-embolic-agent-penetration-into-spinal-dural-arteriovenous-fistula
#13
Dae Chul Suh, Ji Eun Park, Hairi Liu, Sung Chul Jung
OBJECTIVE: To promote embolization of spinal dural arteriovenous fistula (SDAVF) with a small long tortuous feeder that may impede successful application of an embolic agent. METHODS: An induced-wedge technique was developed in which blood flow was blocked by coiling at the proximal part of the microcatheter for secure injection of N-butyl cyanoacrylate. We used this techniques in 11 SDAVF patients (M:F = 8:3): 7 thoracic, 2 lumbar, 1 sacral, and 1 cervical. Clinical outcome was evaluated by the Aminoff-Logue Disability Scale...
September 13, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27615153/minimally-invasive-approach-for-the-treatment-of-lumbar-epidural-arteriovenous-fistulas-with-intradural-venous-reflux
#14
A Najjar, F Zairi, T Sunna, A Weil, L Estrade, A Weill, D Shedid
BACKGROUND: Vascular lesions of the spinal cord are increasingly recognized. The most common types of these lesions are dural arteriovenous fistulas (AVFs) whereas, extradural AVFs are a very rare type of spinal AVF and can be associated with either extradural or intradural venous reflux. This results in neurological deficits through congestive or compressive myeloradiculopathy. These lesions must be treated to allow stabilization or improvement of neurologic status, either by endovascular therapy or microsurgical interruption...
September 8, 2016: Neuro-Chirurgie
https://www.readbyqxmd.com/read/27538140/-retroperitoneal-laparoscopic-nephrectomy-with-autotransplantation-for-severe-iatrogenic-ureteral-injury
#15
H X Zhang, L Zhao, L L Ma, X F Hou, L Liu, S H Deng
OBJECTIVE: To evaluate the safety and efficacy of retroperitoneal laparoscopic nephrectomy with autotransplantation in cases of severe iatrogenic proximal ureteral damage. METHODS: From July 2011 to March 2015, two patients, aged 44 (female) and 54 years (male), underwent retroperitoneal laparoscopic nephrectomy and autotransplantation for treatment of severe iatrogenic proximal ureteral injuries. Both injuries were proximal ureteral avulsion during ureterolithotomy with the holmium laser for ureteral calculi...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27535287/intracardiac-bone-cement-embolism-as-a-complication-of-vertebroplasty-management-strategy
#16
Catherine Hatzantonis, Marcin Czyz, Renata Pyzik, Bronek M Boszczyk
BACKGROUND: Vertebroplasty carries multiple complications due to the leakage of polymethylmethacrylate (PMMA) into the venous system through the iliolumbar or epidural veins. The rate of venous cement complications may vary from 1 to 10 %, with cement extravasation into the venous system in 24 % of patients. Emboli may further migrate into the right heart chambers and pulmonary arteries. Patients may vary in presentation from asymptomatic or symptoms such as syncope to life-threatening complications...
August 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27500272/successful-kidney-transplantation-in-children-with-a-compromised-inferior-vena-cava
#17
Seiichiro Shishido, Takeshi Kawamura, Yuko Hamasaki, Yusuke Takahashi, Yoshihiro Itabashi, Masaki Muramatsu, Hiroyuki Satoh, Atsushi Aikawa
BACKGROUND: Children with a compromised inferior vena cava (IVC) were previously considered unsuitable for kidney transplantation because of the technical difficulties and the increased risk of graft thrombosis secondary to inadequate renal venous outflow. METHODS: We conducted a retrospective study of 11 transplants in 9 patients with end-stage renal disease and thrombosed IVCs who received adult kidney allografts between 2000 and 2015. The mean age at transplantation was 7...
June 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27401745/duplication-of-the-inferior-vena-cava-from-a-division-of-the-left-external-iliac-vein
#18
Sirinad Tankruad, Athikhun Suwannakhan, Chinnawut Suriyonplengsaeng, Krai Meemon
Duplication of the inferior vena cava was detected in a 71-year-old Thai male cadaver with unknown cause of death. Two inferior vena cavae located on each side of the lumbar vertebrae were identified. The right inferior vena cava was formed by fusion of the right and left common iliac veins and had a normal course, while the left inferior vena cava arose from the left branch of the left external iliac vein and ascended parallel to the abdominal aorta. To our knowledge, no similar case has been previously reported...
January 2017: Anatomical Science International
https://www.readbyqxmd.com/read/27389330/retroperitoneal-lymph-node-dissection-anatomical-and-technical-considerations-from-a-cadaveric-study
#19
Tyler S Beveridge, Brian L Allman, Marjorie Johnson, Adam Power, Joel Sheinfeld, Nicholas E Power
PURPOSE: Metastatic testis cancer in the retroperitoneum presents a technical challenge to urologists in the primary and post-chemotherapy settings. Where possible, bilateral nerve sparing retroperitoneal lymph node dissection should be performed in an effort to preserve ejaculatory function. However, this is often difficult to achieve, given the complex neurovascular anatomy. We performed what is to our knowledge the first comprehensive examination of the anatomical relationships between the sympathetic nerves of the aortic plexus and the lumbar vessels to facilitate navigation and nerve sparing during bilateral retroperitoneal lymph node dissection...
July 5, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27379417/the-underlying-anatomy-and-typing-diagnosis-of-may-thurner-syndrome-and-clinical-significance-an-observation-based-on-ct
#20
Lin Ou-Yang, Guang-Ming Lu
STUDY DESIGN: Cross-sectional study. OBJECTIVE: To explore the underlying anatomy of MTS using CT and discuss its clinical significance for typing diagnosis. SUMMARY OF BACKGROUND DATA: Because the anatomical position of the corpse cannot fully illustrate the actual clinical situation in vivo, the diversity of MTS has not been fully elucidated yet. METHODS: Retrospectively analysed the data of 69 patients with MTS. By CT showing, patients were categorized to simple MTS (sMTS, 22), lumbar degeneration-related MTS (dMTS, 33) and other causes MTS (oMTS, 14); meanwhile, a healthy control group were set...
July 1, 2016: Spine
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