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JOURNAL ARTICLE
Brian M Casey, Lisa Mele, Alan M Peaceman, Michael W Varner, Uma M Reddy, Ronald J Wapner, John M Thorp, George R Saade, Alan T N Tita, Dwight J Rouse, Baha M Sibai, Maged M Costantine, Brian M Mercer, Steve N Caritis
OBJECTIVE: Our objective was to evaluate whether iodine status in pregnant patients with either subclinical hypothyroidism or hypothyroxinemia in the first half of pregnancy is associated with measures of behavior and neurodevelopment in children through the age of 5 years. STUDY DESIGN: This is a secondary analysis of a multicenter study consisting of two randomized, double-masked, placebo-controlled treatment trials conducted in parallel. Patients with a singleton gestation before 20 weeks' gestation underwent thyroid screening using serum thyrotropin and free thyroxine...
January 16, 2024: American Journal of Perinatology
#22
RANDOMIZED CONTROLLED TRIAL
Jiajie Chen, Haiping Shi, Wanli Gao, Xiaowei Li, Yuling Shu, Yongzhe Wang, Binjian Jiang, Jun Yang, Pin Wang
OBJECTIVES: To compare the clinical effect on Bell's facial palsy in the acute stage between the staging comprehensive treatment with acupuncture-moxibustion and western medication. METHODS: Sixty patients with Bell's facial palsy in the acute stage were randomly divided into an observation group and a control group, with 30 cases in each one. The patients in the control group were administered orally with prednisone acetate tablets and methylcobalamin tablets until the 28th day of illness...
January 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
#23
MULTICENTER STUDY
Jennifer L Grasch, Jessica A de Voest, George R Saade, Brenna L Hughes, Uma M Reddy, Maged M Costantine, Edward K Chien, Alan T N Tita, John M Thorp, Torri D Metz, Ronald J Wapner, Vishakha Sabharwal, Hyagriv N Simhan, Geeta K Swamy, Kent D Heyborne, Baha M Sibai, William A Grobman, Yasser Y El-Sayed, Brian M Casey, Samuel Parry
OBJECTIVE: To characterize breastfeeding behaviors and identify factors associated with breastfeeding initiation among people with hepatitis C virus (HCV) infection. METHODS: We conducted a secondary analysis of a multicenter observational cohort of pregnant people with singleton gestations and HCV seropositivity. This analysis includes individuals with data on breastfeeding initiation and excludes those with human immunodeficiency virus (HIV) co-infection. The primary outcome was self-reported initiation of breastfeeding or provision of expressed breast milk...
March 1, 2024: Obstetrics and Gynecology
#24
JOURNAL ARTICLE
Marta B Davidson, James A Kennedy, Jose-Mario Capo-Chichi, Yuliang Shi, Wei Xu, Verna Cheung, Andrea Arruda, Aniket Bankar, Guillaume Richard-Carpentier, Steven Chan, Dawn Maze, Mark D Minden, Aaron D Schimmer, Andre C Schuh, Hassan Sibai, Karen Yee, Anne Tierens, Auro Viswabandya, Vikas Gupta
Transformation of BCR::ABL1-negative myeloproliferative neoplasms (MPN) to an accelerated or blast phase is associated with poor outcomes. The efficacy of acute myeloid leukemia (AML)-type intensive and nonintensive hypomethylating agent-based regimens is not well studied. We therefore performed a retrospective analysis of patients with MPN-AP/BP (N = 138) treated with intensive (N = 81) and nonintensive (N = 57) blast-reduction strategies. We used clinically relatable response criteria developed at the Princess Margaret Cancer Centre...
March 12, 2024: Blood Advances
#25
JOURNAL ARTICLE
Federico C Carini, Federico Angriman, Damon C Scales, Laveena Munshi, Lisa D Burry, Hassan Sibai, Sangeeta Mehta, Bruno L Ferreyro
PURPOSE: The aim of this study was to describe the incidence of venous thromboembolism (VTE) and major bleeding among hospitalized patients with hematologic malignancy, assessing its association with critical illness and other baseline characteristics. METHODS: We conducted a population-based cohort study of hospitalized adults with a new diagnosis of hematologic malignancy in Ontario, Canada, between 2006 and 2017. The primary outcome was VTE (pulmonary embolism or deep venous thrombosis)...
January 3, 2024: Intensive Care Medicine
#26
JOURNAL ARTICLE
Tracy Murphy, Jacqueline M Mason, Brian Leber, Mark R Bray, Steven M Chan, Vikas Gupta, Dina Khalaf, Dawn Maze, Caroline J McNamara, Aaron D Schimmer, Andre C Schuh, Hassan Sibai, Michael Trus, Debbie Valiquette, Kylie Martin, Linh Nguyen, Xuan Li, Tak W Mak, Mark D Minden, Karen W L Yee
CFI-400945 is a selective oral polo-like kinase 4 (PLK4) inhibitor that regulates centriole duplication. PLK4 is aberrantly expressed in patients with acute myeloid leukemia (AML). Preclinical studies indicate that CFI-400945 has potent in vivo efficacy in hematological malignancies and xenograft models, with activity in cells harboring TP53 mutations. In this phase 1 study in very high-risk patients with relapsed/refractory AML and myelodysplastic syndrome (MDS) (NCT03187288), 13 patients were treated with CFI-400945 continuously in dose escalation from 64 mg/day to 128 mg/day...
December 19, 2023: Leukemia
#27
JOURNAL ARTICLE
Ahmet Özer Şehirli, Umut Aksoy, Abdullah Sibai, Kaan Orhan, Serkan Sayıner
AIM: This study aimed to investigate the potential protective effects of N-acetyl-L-cysteine (NAC) against apical periodontitis (AP) in rats with adriamycin (ADR)-induced kidney and heart diseases. METHODOLOGY: Fourty-eight Wistar albino rats were divided into six groups: (1) Control group, (2) ADR group (1 mg/kg/day ip for 10 days), (3) AP Group (1st mandibular molar tooth), (4) AP + ADR Group, (5) AP + NAC group (150 mg/kg/day ip), and (6) AP + ADR + NAC group...
December 9, 2023: International Endodontic Journal
#28
Transient ovarian torsion in a pregnant woman after vitrified-warmed embryo transfer: a case report.
Hoda Sibai, Ahmed Ismail Heraiz, Nadia M Madkour
Assisted reproduction is a risk factor for adnexal torsion due to ovarian hyperstimulation and increased incidence of twin pregnancy. Both risk factors can be eliminated in frozen embryo transfers, but in our case ovarian torsion occurred after the use of an aromatase inhibitor (Femara) in endometrium preparation due to the presence of corpus luteum. Case presentation: G2P1+0 presented at 7 weeks gestation after vitrified-warmed embryo transfer with right loin pain and mild right iliac pain and tenderness. Ultrasound examination revealed transient or incomplete ovarian torsion...
November 14, 2023: JBRA Assisted Reproduction
#29
JOURNAL ARTICLE
Beth L Pineles, Mallory Vial, Tania Castro, Tala Ghorayeb, Oluwadare Ajishegiri, Sandra Sadek, Claudia Pedroza, Sean C Blackwell, Suneet P Chauhan, Baha M Sibai
BACKGROUND: Individuals hospitalized with preterm prelabor rupture of membranes are often advised to limit their activity or adhere to bed rest. Some evidence suggests that greater activity is associated with longer latency and improved outcomes, but no high-quality evidence from a randomized controlled trial exists. OBJECTIVE: This study aimed to evaluate whether encouragement to ambulate at least 2000 steps daily affects latency among individuals with preterm prelabor rupture of membranes compared with usual care...
November 8, 2023: American journal of obstetrics & gynecology MFM
#30
JOURNAL ARTICLE
Dawn Maze, Murat O Arcasoy, Ryan Henrie, Sonia Cerquozzi, Rammurti Kamble, Samer Al-Hadidi, Abdulraheem Yacoub, Anurag K Singh, Mahmoud Elsawy, Shireen Sirhan, Elliot Smith, Curtis Marcoux, Auro Viswabandya, Andrew Daly, Hassan Sibai, Caroline McNamara, Yuliang Shi, Wei Xu, Katherine Lajkosz, Lynda Foltz, Vikas Gupta
Allogeneic hematopoietic cell transplantation (HCT) is the only curative therapy for myelofibrosis (MF) and is recommended for patients with higher risk disease. However, there is a risk of early mortality, and optimal timing is unknown. JAK inhibitor (JAKi) therapy may offer durable improvement in symptoms, splenomegaly and quality of life. The aim of this multicentre, retrospective observational study was to compare outcomes of patients aged 70 years or below with MF in chronic phase who received upfront JAKi therapy vs...
November 8, 2023: Bone Marrow Transplantation
#31
JOURNAL ARTICLE
E Hernandez-Andrade, E S Huntley, B Sibai, S C Blackwell, E E Soto-Torres
OBJECTIVE: To associate changes in cervical length (CL) after vaginal progesterone treatment with preterm delivery (PTD) METHODS: This is a retrospective cohort study that included 197 singleton pregnancies without (n=178) and with (n=19) history of PTD who were found to have a short cervix (≤25mm) between 18+0 and 23+6 weeks/days of gestation and subsequently had a follow up transvaginal cervical length at least one-week after vaginal progesterone treatment started. ROC analysis was performed and three CL shortening patterns evaluated: 1) ≥10% reduction, 2) ≥20% reduction, and 3) ≥5 mm reduction in relation to the first measurement...
November 2, 2023: Ultrasound in Obstetrics & Gynecology
#32
JOURNAL ARTICLE
Melodie Al Daccache, Laila Al-Shaar, Abla Mehio Sibai, Hussain Ismaeel, Kamal Badr, Lara Nasreddine
Cardiovascular diseases are increasing at an alarming rate worldwide, reaching epidemic proportions in countries of the Eastern Mediterranean Region, including Lebanon. Despite the growing number of patients suffering from cardiovascular diseases in Lebanon, there is scarce data on whether cardiac patients adhere to therapeutic dietary guidelines, drug prescriptions, and physical activity recommendations and whether such adherence differs according to sociodemographic, lifestyle, or psychosocial characteristics...
2023: PloS One
#33
JOURNAL ARTICLE
Nayla G Kazzi, Han-Yang Chen, Linden Lee, Sarah Nazeer, Kendra Brown, Baha M Sibai, Suneet Chauhan
OBJECTIVE: (1) To study the effect of sustained hypotension after spinal on neonatal acidosis and adverse outcomes in those undergoing scheduled cesarean delivery (CD) with universal prophylactic vasopressor exposure. (2) To examine differences in spinal-to-delivery time by neonatal acidosis status. STUDY DESIGN: This retrospective cohort study conducted at a quaternary care center from January 2019 to December 2021 included singleton, term, non-anomalous pregnancies, with scheduled CD under spinal anesthesia...
October 23, 2023: American Journal of Perinatology
#34
Sahil Navlani, Akshata Mestha, Amritendu Mukherjee, Ahmad Saadat Abdelmuhdi, Ayman A Sibaie
Developmental venous anomalies (DVAs) are intracranial vascular malformations typically characterized by their benign nature, often obviating the need for radiological follow-up. These anomalies arise from variations in the standard drainage pattern. While previously deemed congenital, there has been ongoing debate about a developmental component contributing to their etiology. They frequently coexist with other cerebral venous malformations (CVM); however, their association with arteriovenous malformations (AVM) is exceedingly rare...
August 2023: Curēus
#35
JOURNAL ARTICLE
Rebecca Horgan, Yara Hage Diab, Michal Fishel Bartal, Baha M Sibai, George Saade
Diabetes mellitus in pregnancy is associated with adverse maternal and neonatal outcomes. Optimal glycemic control is associated with improved outcomes. Continuous glucose monitoring is a less invasive alternative to blood glucose measurements. Two types of continuous glucose monitoring are available in the market: real time and intermittently scanned. Continuous glucose monitoring is gaining popularity and is now recommended by some societies for glucose monitoring in pregnant women. In this review, we discuss the differences between the two types of continuous glucose monitoring, optimal treatment goals, and whether there is an improvement in maternal or neonatal outcomes...
September 28, 2023: Obstetrics and Gynecology
#36
JOURNAL ARTICLE
Erin J Bailey, Alan T N Tita, Justin Leach, Kim Boggess, Lorraine Dugoff, Baha Sibai, Kirsten Lawrence, Brenna L Hughes, Joseph Bell, Kjersti Aagaard, Rodney K Edwards, Kelly Gibson, David M Haas, Lauren Plante, Torri D Metz, Brian M Casey, Sean Esplin, Sherri Longo, Matthew Hoffman, George R Saade, Janelle Foroutan, Methodius G Tuuli, Michelle Y Owens, Hyagriv N Simhan, Heather A Frey, Todd Rosen, Anna Palatnik, Susan Baker, Phyllis August, Uma M Reddy, Wendy Kinzler, Emily J Su, Iris Krishna, Nicki Nguyen, Mary E Norton, Daniel Skupski, Yasser Y El-Sayed, Dotun Ogunyemi, Zorina S Galis, Lorie Harper, Namasivayam Ambalavanan, Suzanne Oparil, Hui-Chien Kuo, Jeff M Szychowski, Kara Hoppe
OBJECTIVE: To evaluate the association between maternal blood pressure (BP) below 130/80 mm Hg compared with 130-139/80-89 mm Hg and pregnancy outcomes. METHODS: We conducted a planned secondary analysis of CHAP (Chronic Hypertension and Pregnancy), an open label, multicenter, randomized controlled trial. Participants with mean BP below 140/90 mm Hg were grouped as below 130/80 mm Hg compared with 130-139/80-89 mm Hg by averaging postrandomization clinic BP throughout pregnancy...
September 28, 2023: Obstetrics and Gynecology
#37
JOURNAL ARTICLE
Nicholas Errol Rahim, David Flood, Maja E Marcus, Michaela Theilmann, Taing N Aung, Kokou Agoudavi, Krishna Kumar Aryal, Silver Bahendeka, Brice Bicaba, Pascal Bovet, Alpha Oumar Diallo, Farshad Farzadfar, David Guwatudde, Corine Houehanou, Dismand Houinato, Nahla Hwalla, Jutta Jorgensen, Gibson Bernard Kagaruki, Mary Mayige, Roy Wong-McClure, Bagher Larijani, Sahar Saeedi Moghaddam, Omar Mwalim, Kibachio Joseph Mwangi, Sudipa Sarkar, Abla M Sibai, Lela Sturua, Chea Wesseh, Pascal Geldsetzer, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Justine Davies, Mohammed K Ali, Jacqueline A Seiglie, Jennifer Manne-Goehler
BACKGROUND: The global burden of diabetes is rising rapidly, yet there is little evidence on individual-level diabetes prevention activities undertaken by health systems in low-income and middle-income countries (LMICs). Here we describe the population at high risk of developing diabetes, estimate diabetes prevention activities, and explore sociodemographic variation in these activities across LMICs. METHODS: We performed a pooled, cross-sectional analysis of individual-level data from nationally representative, population-based surveys conducted in 44 LMICs between October, 2009, and May, 2019...
October 2023: Lancet Global Health
#38
JOURNAL ARTICLE
Cara Buskmiller, Michal Fishel Bartal, Miguel Bonilla, Chloe Denham, Rachel Nguyen, Baha Sibai, Claudia Pedroza, Edgar Hernandez-Andrade
OBJECTIVE: Second-trimester ultrasound is the standard technique for fetal anatomy evaluation in the United States despite international guidelines and literature that suggest that first-trimester timing may be superior in obese patients. First-trimester imaging performs well in cohorts of obese participants. Our aim was to compare the completion rate of first-trimester fetal anatomy to second-trimester fetal anatomy ultrasound in pregnant people with body mass index (BMI) ≥ 35 kg/m2 ...
September 3, 2023: American journal of obstetrics & gynecology MFM
#39
(no author information available yet)
Professor Abla Mehio Sibai talks to Lynn Eaton about the need for cross-disciplinary approaches to supporting healthy ageing and the challenges posed by the collapsing public sector in Lebanon.
September 1, 2023: Bulletin of the World Health Organization
#40
JOURNAL ARTICLE
Andria Theophanous, Andri Christodoulou, Charalambia Mattheou, Dany S Sibai, Tom Moss, Niovi Santama
Transcription/processing of the rRNA precursor, as part of ribosome biosynthesis, is intensively studied and characterized in eukaryotic cells. Here, we constructed shRNA-based mouse cell lines partially silenced for the Upstream Binding Factor UBF, master regulator of rRNA transcription and organizer of open rDNA chromatin. Full Ubf silencing in vivo is not viable and these new tools allow further characterization of rRNA transcription and its co-ordination with cellular signaling. shUBF cells display cell cycle G1 delay, reduced 47S rRNA precursor and 28S rRNA at baseline and serum-challenged conditions...
September 1, 2023: Journal of Biological Chemistry
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