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RANDOMIZED CONTROLLED TRIAL
Xinyue Hou, Jianquan Wang, Zefeng Kang, Yingxin Yang, Xiaoping Yao, Fengmei Zhang, Jing Yao, Jingsheng Yu, Xinquan Liu, Fengming Liang, Xiaoyi Yu, Man Song
OBJECTIVES: To observe the clinical effect and safety of auricular point sticking combined with periocular needle-embedding therapy for pseudomyopia and prevention of true myopia. METHODS: A total of 269 children with pseudomyopia were randomized into an observation group (134 cases, 2 cases dropped out) and a control group (135 cases, 5 cases dropped out). In the control group, the healthy education was provided. In the observation group, besides the intervention as the control group, the auricular point sticking was delivered at gan (CO12 ), pi (CO13 ), xin (CO15 ) and yan (LO5 ) on one ear in each treatment, combined with periocular needle-embedding technique at bilateral Cuanzhu (BL 2), Yuyao (EX-HN 4) and Sibai (ST 2)...
April 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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JOURNAL ARTICLE
Erin S Huntley, Benjamin Jf Huntley, Miguel Bonilla Moreno, Ellen Crowe, Claudia Pedroza, Hector Mendez-Figueroa, Baha M Sibai, Suneet Chauhan
BACKGROUND: Standardization of procedures improves outcomes. Though systematic reviews have summarized the evidence-based steps (EBS) of cesarean delivery (CD), their bundled implementation has not been investigated. OBJECTIVE: In this pre- and post-implementation trial, we sought to ascertain if bundled EBS of CD, compared to surgeon's preference, improves outcomes. STUDY DESIGN: A StaRI (Standards for Reporting Implementation Studies) compliant, multi-center pre- and post-implementation trial at 4 teaching hospitals was conducted...
April 8, 2024: American Journal of Obstetrics and Gynecology
#3
JOURNAL ARTICLE
Yossi Bart, Suneet P Chauhan, Michal Fishel Bartal, Sean Blackwell, Baha M Sibai
BACKGROUND: The recent paradigm shift of treating individuals at risk of late preterm birth with antenatal corticosteroids warrants an assessment of the effect of single dosage. OBJECTIVE: To compare outcomes of neonates born in the late preterm period (34.0-36.6 weeks) following a single dose of antenatal corticosteroids versus placebo. STUDY DESIGN: We performed a secondary analysis of the Antenatal Late Preterm Steroids (ALPS) trial (Gyamfi-Bannerman C...
April 6, 2024: American Journal of Obstetrics and Gynecology
#4
JOURNAL ARTICLE
Aaron W Roberts, Mr John Hotra, Eleazar Soto, Claudia Pedroza, Baha M Sibai, Sean C Blackwell, Suneet P Chauhan
BACKGROUND: In low-risk pregnancies, third trimester ultrasound examination is indicated if fundal height measurement and gestational age discrepancy is observed. Despite potential improvement in detection of ultrasound abnormality, prior trials to date on universal third trimester ultrasound examination in low-risk pregnancies, compared to indicated ultrasound examination, have not demonstrated improvement in neonatal or maternal adverse outcomes. OBJECTIVE: The primary objective was to determine if universal third trimester ultrasound examination in low-risk pregnancies could attenuate composite neonatal adverse outcome...
April 5, 2024: American journal of obstetrics & gynecology MFM
#5
JOURNAL ARTICLE
Kristen Cagino, Rachel L Wiley, Ipsita Ghose, Hailie Ciomperlik, Baha M Sibai, Hector Mendez-Figueroa, Suneet Chauhan
We aimed to determine the composite maternal hemorrhagic outcome (CMHO) among individuals with and without HDP, stratified by disease severity. Additionally, we investigated the composite neonatal adverse outcome (CNAO) among individuals with HDP who had versus did not have PPH. Our retrospective cohort study included all singletons who delivered at a Level IV center over two consecutive years. The primary outcome was the rate of CMHO, defined as blood loss ≥ 1000 mL, use of uterotonics, mechanical tamponade, surgical techniques for atony, transfusion, venous thromboembolism, ICU admission, hysterectomy, or maternal death...
April 2, 2024: American Journal of Perinatology
#6
JOURNAL ARTICLE
Sayed Emal Wahezi, Trent D Emerick, Moorice Caparó, Heejung Choi, Yashar Eshraghi, Tahereh Naeimi, Lynn Kohan, Magdalena Anitescu, Thelma Wright, Rene Przkora, Kiran Patel, Tim J Lamer, Susan Moeschler, Ugur Yener, Jonathan Alerte, Radhika Grandhe, Alexander Bautista, Boris Spektor, Kristen Noon, Rajiv Reddy, Uzondu C Osuagwu, Anna Carpenter, Frederic J Gerges, Danielle B Horn, Casey A Murphy, Chong Kim, Scott G Pritzlaff, Cameron Marshall, Gwynne Kirchen, Christine Oryhan, Tejinder S Swaran Singh, Dawood Sayed, Timothy R Lubenow, Nalini Sehgal, Charles E Argoff, Amit Gulati, Miles R Day, Naum Shaparin, Nabil Sibai, Anterpreet Dua, Meredith Barad
INTRODUCTION: The Accreditation Council for Graduate Medical Education (ACGME) approved the first pain medicine fellowship programs over three decades ago, designed around a pharmacological philosophy. Following that, there has been a rise in the transition of pain medicine education toward a multidisciplinary interventional model based on a tremendous surge of contemporaneous literature in these areas. This trend has created variability in clinical experience and education amongst accredited pain medicine programs with minimal literature evaluating the differences and commonalities in education and experience of different pain medicine fellowships through Program Director (PD) experiences...
March 30, 2024: Pain Practice: the Official Journal of World Institute of Pain
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JOURNAL ARTICLE
Alpha Oumar Diallo, Maja E Marcus, David Flood, Michaela Theilmann, Nicholas E Rahim, Alan Kinlaw, Nora Franceschini, Til Stürmer, Dessie V Tien, Mohsen Abbasi-Kangevari, Kokou Agoudavi, Glennis Andall-Brereton, Krishna Aryal, Silver Bahendeka, Brice Bicaba, Pascal Bovet, Maria Dorobantu, Farshad Farzadfar, Seyyed-Hadi Ghamari, Gladwell Gathecha, David Guwatudde, Mongal Gurung, Corine Houehanou, Dismand Houinato, Nahla Hwalla, Jutta Jorgensen, Gibson Kagaruki, Khem Karki, Joao Martins, Mary Mayige, Roy Wong McClure, Sahar Saeedi Moghaddam, Omar Mwalim, Kibachio Joseph Mwangi, Bolormaa Norov, Sarah Quesnel-Crooks, Abla Sibai, Lela Sturua, Lindiwe Tsabedze, Chea Wesseh, Pascal Geldsetzer, Rifat Atun, Sebastian Vollmer, Till Bärnighausen, Justine Davies, Mohammed K Ali, Jacqueline A Seiglie, Emily W Gower, Jennifer Manne-Goehler
The prevalence of multiple age-related cardiovascular disease (CVD) risk factors is high among individuals living in low- and middle-income countries. We described receipt of healthcare services for and management of hypertension and diabetes among individuals living with these conditions using individual-level data from 55 nationally representative population-based surveys (2009-2019) with measured blood pressure (BP) and diabetes biomarker. We restricted our analysis to non-pregnant individuals aged 40-69 years and defined three mutually exclusive groups (i...
2024: PLOS Glob Public Health
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JOURNAL ARTICLE
Maria Agustina Perusini, Claire Andrews, Eshetu G Atenafu, Vikas Gupta, Dawn Maze, Andre C Schuh, Karen Wl Yee, Aniket Bankar, Marta B Davidson, Guillaume Richard-Carpentier, Steven M Chan, Jad Sibai, Aaron D Schimmer, Mark D Minden, Hassan Sibai
This retrospective report presents the outcomes and adverse events (AEs) observed in 73 patients aged 60 years or older diagnosed with Philadelphia Chromosome-negative Acute Lymphoblastic Leukemia (Ph-negative ALL) treated with a pediatric-inspired protocol incorporating either Pegylated (PEG-ASP) or Native Asparaginase (EC-ASP). Notably, 61% of patients experienced AEs of Grade III-IV severity. The most prevalent AEs included thrombosis (35.6%), febrile neutropenia (38.4%), and transaminitis (34.2%). AEs did not translate into significant differences concerning overall survival, leukemia-free survival, or early mortality...
December 2024: Hematology (Amsterdam, Netherlands)
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EDITORIAL
Jad Sibai, Keyvan Karkouti, Stuart A McCluskey
No abstract text is available yet for this article.
March 20, 2024: Canadian Journal of Anaesthesia
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JOURNAL ARTICLE
Mahmoud Elshenawy, Sarah Khaled Aldahoul, Abduljalil Mohamed El-Sibai, Alaa Hamad, Tarek Ziad Arabi, Saleha Abdul Rab, Ahmed Badran, Tariq Alzaid, Belal Nedal Sabbah, Jean Paul Atallah
BACKGROUND Adamantinoma is a rare low-grade malignant bone tumor, usually found in the tibial diaphysis and metaphysis, with histological similarities to mandibular ameloblastoma. The most effective treatment of recurrent adamantinoma is not yet clear. This report is of a 22-year-old woman with recurrent tibial adamantinoma treated with the tyrosine kinase inhibitor pazopanib. CASE REPORT We report the case of a 22-year-old woman who was referred to our center for a suspicious bone lesion in the right tibia...
March 15, 2024: American Journal of Case Reports
#11
REVIEW
Asma Ghazzy, Hamdi Nsairat, Rana Said, Obada A Sibai, Aseel AbuRuman, Alaa S Shraim, Afnan Al Hunaiti
Iron oxide nanozymes (IONzymes) are a class of magnetic nanoparticles that mimic the enzymatic activity of natural enzymes. These particles have received significant attention in recent years due to their unique properties, such as high stability, tunable magnetic responsiveness, and ability to act as biocatalysts for various chemical reactions. In this review, we aim to provide an overview of the production methods of magnetic nanozymes, including chemical, physical, and biological synthesis. The structure and design of magnetic nanozymes are also discussed in detail, as well as their applications in various fields such as biomedicine and environmental science...
March 12, 2024: Nanoscale advances
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JOURNAL ARTICLE
Ryan F Relich, Kayla Van Benten, Guang-Sheng Lei, Christopher M Robinson, Mariel Carozza, Malaya K Sahoo, ChunHong Huang, Daniel Solis, Mamdouh Sibai, Christopher A Myers, Cynthia Sikorski, Caroline Balagot, David Yang, Benjamin A Pinsky, Michael J Loeffelholz
Despite having high analytical sensitivities and specificities, qualitative SARS-CoV-2 nucleic acid amplification tests (NAATs) cannot distinguish infectious from non-infectious virus in clinical samples. In this study, we determined the highest cycle threshold (Ct) value of the SARS-CoV-2 targets in the Xpert Xpress SARS-CoV-2/Flu/RSV (Xpert 4plex) test that corresponded to the presence of detectable infectious SARS-CoV-2 in anterior nasal swab samples. A total of 111 individuals with nasopharyngeal swab specimens that were initially tested by the Xpert Xpress SARS-CoV-2 test were enrolled...
March 11, 2024: Microbiology Spectrum
#13
Mason Hui, Baha Sibai, Alvaro Montealegre, Mateo G Leon
Uterine leiomyomas are common benign smooth muscle tumors that often occur during the reproductive years. Although many cases may not result in significant complications, negative pregnancy outcomes have been associated with the size and location of the fibroids. Degeneration of fibroids can occur as early as the late first trimester when they undergo significant volumetric growth, contributing to pain during pregnancy. While myomectomy is typically avoided during pregnancy, conservative management with anti-inflammatory medications may be effective...
January 2024: American Journal of Perinatology Reports
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JOURNAL ARTICLE
James T England, Natasha Szuber, Shireen Sirhan, Tom Dunne, Sonia Cerquozzi, Madeleine Hill, Pierre J A Villeneuve, Jenny M Ho, Bekim Sadikovic, Pratibha Bhai, Nupur Krishnan, Sebastian Dowhanik, Chris Hillis, Jose-Mario Capo-Chichi, Hubert Tsui, Verna Cheung, Karine Gauthier, Hassan Sibai, Marta B Davidson, Aniket Bankar, Rouslan Kotchetkov, Vikas Gupta, Dawn Maze
Myeloproliferative neoplasms (MPNs) are a group of chronic hematologic malignancies that lead to morbidity and early mortality due to thrombotic complications and progression to acute leukemia. Clinical and mutational risk factors have been demonstrated to predict outcomes in patients with MPNs and are used commonly to guide therapeutic decisions, including allogenic stem cell transplant, in myelofibrosis. Adolescents and young adults (AYA, age ≤45 years) comprise less than 10% of all MPN patients and have unique clinical and therapeutic considerations...
March 2024: Leukemia
#15
JOURNAL ARTICLE
Paula Punzon-Jimenez, Alba Machado-Lopez, Raul Perez-Moraga, Jaime Llera-Oyola, Daniela Grases, Marta Galvez-Viedma, Mustafa Sibai, Elena Satorres-Perez, Susana Lopez-Agullo, Rafael Badenes, Carolina Ferrer-Gomez, Eduard Porta-Pardo, Beatriz Roson, Carlos Simon, Aymara Mas
Age-associated myometrial dysfunction can prompt complications during pregnancy and labor, which is one of the factors contributing to the 7.8-fold increase in maternal mortality in women over 40. Using single-cell/single-nucleus RNA sequencing and spatial transcriptomics, we have constructed a cellular atlas of the aging myometrium from 186,120 cells across twenty perimenopausal and postmenopausal women. We identify 23 myometrial cell subpopulations, including contractile and venous capillary cells as well as immune-modulated fibroblasts...
January 31, 2024: Nature Communications
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JOURNAL ARTICLE
Josephine Lucero, Muhned Alhumaid, Igor Novitzky-Basso, Jose-Mario Capo-Chichi, Tracy Stockley, Vikas Gupta, Aniket Bankar, Steven Chan, Andre C Schuh, Mark Minden, Jonas Mattsson, Rajat Kumar, Hassan Sibai, Anne Tierens, Dennis D H Kim
Measurable residual disease (MRD) monitoring independently predicts long-term outcomes in patients with acute myeloid leukemia (AML). Of the various modalities available, multiparameter flow cytometry-based MRD analysis is widely used and relevant for patients without molecular targets. In the transplant (HCT) setting, the presence of MRD pre-HCT is associated with adverse outcomes. MRD-negative remission status pre-HCT was also associated with longer overall (OS) and progression-free survival and a lower risk of relapse...
January 30, 2024: Annals of Hematology
#17
REVIEW
Rebecca Horgan, Yara Hage Diab, Michal Fishel Bartal, Baha M Sibai, George Saade
In recent years, the American College of Cardiology and the American Heart Association have reduced the thresholds for a hypertension diagnosis among nonpregnant adults. This change has led to more individuals with reproductive potential to be labeled as being chronically hypertensive, and some were started on antihypertensive medications. When these individuals become pregnant, the obstetrical care provider will have to decide whether to manage them as individuals with chronic hypertensive when only a few years ago they would have been managed as normotensive individuals and when the evidence regarding treatment of these patients during pregnancy is limited...
March 2024: American journal of obstetrics & gynecology MFM
#18
Dawn Maze, Murat O Arcasoy, Ryan Henrie, Sonia Cerquozzi, Rammurti Kamble, Samer Al-Hadidi, Abdulraheem Yacoub, Anurag K Singh, Mahmoud Elsawy, Shireen Sirhan, Elliot Smith, Curtis Marcoux, Auro Viswabandya, Andrew Daly, Hassan Sibai, Caroline McNamara, Yuliang Shi, Wei Xu, Katherine Lajkosz, Lynda Foltz, Vikas Gupta
No abstract text is available yet for this article.
January 26, 2024: Bone Marrow Transplantation
#19
REVIEW
Salma Adeeb, Tarek Ziad Arabi, Hassan Shah, Sulaiman Alsalameh, Mylia Abu-Shaar, Abduljalil Mohamed El-Sibai, Khaled Alkattan, Ahmed Yaqinuddin
Neutrophil extracellular traps (NETs) play an essential role in antimicrobial defense. However, NETs have also been shown to promote and mediate a wide spectrum of diseases, including cancer, diabetes mellitus, cardiovascular diseases, and ocular diseases. Data regarding NETs in ocular diseases remain limited. In physiological conditions, NETs protect the eye from debris and cleave proinflammatory cytokines, including several interleukins. On the other hand, NETs play a role in corneal diseases, such as dry eye disease and ocular graft-versus-host disease, where they promote acinar atrophy and delayed wound healing...
January 17, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Sarah A Nazeer, Han-Yang Chen, Suneet P Chauhan, Sean C Blackwell, Baha Sibai, Michal Fishel Bartal
BACKGROUND: Unlike pregestational diabetes mellitus, the American College of Obstetricians and Gynecologists recommends antenatal corticosteroids in those with gestational diabetes mellitus at risk for preterm birth. However, this recommendation is based on limited data, only 10.6% of the Antenatal Late Preterm Steroids study sample had gestational diabetes mellitus. There is a paucity of data on the risk of neonatal respiratory and other morbidity in this population. OBJECTIVE: This study aimed to examine respiratory outcomes in parturients with gestational diabetes mellitus who received antenatal corticosteroids and delivered during the late preterm period vs those who did not...
March 2024: American journal of obstetrics & gynecology MFM
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