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https://www.readbyqxmd.com/read/28885783/uterine-balloon-tamponade-for-the-management-of-postpartum-haemorrhage-a-challenge-and-an-opportunity-for-better-evidence
#1
O A Viteri, B M Sibai
Postpartum haemorrhage (PPH) is a leading cause of maternal morbidity and mortality worldwide.The most common cause of PPH is uterine atony (80%) of cases, resulting from suboptimal uterine involution and poor contraction of spiral arteries following placental separation. The goal of therapy is timely intervention to prevent haemorrhagic hypovolemic shock, intravascular disseminated coagulopathy, reduced tissue perfusion, and metabolic acidosis. This article is protected by copyright. All rights reserved.
September 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28885417/association-of-nonsteroidal-antiinflammatory-drugs-and-postpartum-hypertension-in-women-with-preeclampsia-with-severe-features
#2
Oscar A Viteri, Joey A England, Mesk A Alrais, Kayla A Lash, Maria I Villegas, Olaide A Ashimi Balogun, Suneet P Chauhan, Baha M Sibai
OBJECTIVE: To estimate whether nonsteroidal antiinflammatory drugs (NSAIDs) are associated with persistent postpartum hypertension in a cohort of women with preeclampsia and severe features. METHODS: We conducted a retrospective cohort study at a single, tertiary center from January 2013 to December 2015. All women diagnosed with severe preeclampsia who remained hypertensive for greater than 24 hours after delivery were included. The primary outcome was the rate of persistent postpartum hypertension, defined as systolic blood pressure 150 mm Hg or greater or diastolic 100 mm Hg or greater (or both), on two occasions, at least 4 hours apart...
September 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28872682/%C3%AE-2-himachalen-6-ol-protects-against-skin-cancer-development-in%C3%A2-vitro-and-in%C3%A2-vivo
#3
Hamid E Daaboul, Costantine F Daher, Robin I Taleb, Joelle Boulos, Kikki Bodman-Smith, Petra Boukamp, Wassim N Shebaby, Carol Dagher, Mirvat El-Sibai, Mohamad A Mroueh
BACKGROUND: Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses remarkable in-vitro anticancer activity and antitumour promoting effect against DMBA/TPA skin carcinogenesis in mice. Chemical analysis of DCOE led to the isolation of the β-2-himachalen-6-ol (HC), major sesquiterpene with a potent anticancer activity against various colon, breast, brain and skin cancer cells. This study investigated the anticancer activity of HC against invasive epidermal squamous cell carcinoma cells and evaluated its effect in a DMBA/TPA skin carcinogenesis Balb/c murine model...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28872218/adolescents-self-perceived-and-actual-weight-which-plays-a-dominant-role-in-weight-loss-behaviour-in-lebanon
#4
S Assaad, S Anouti, F Naja, L Nasreddine, N Hwalla, A M Sibai
BACKGROUND: The decision to lose weight among adolescents is complex and is guided by a number of body-related factors. This study examined the extent of agreement between actual weight, measured as body mass index, and self-perceived weight and assessed their relative importance in weight loss behaviour among Lebanese adolescents. METHODS: Data on 278 adolescents aged 13-17 years were drawn from the nationwide Nutrition and Non-Communicable Disease Risk Factor Survey (Lebanon, 2009)...
September 4, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28865040/the-impact-of-peri-operative-dexamethasone-administration-on-the-normal-hypothalamic-pituitary-adrenal-response-to-major-surgical-procedures
#5
Katia El-Sibai, Aman Rajpal, Ribal Al-Aridi, Warren R Selman, Baha M Arafah
BACKGROUND: Surgical procedures are associated with activation of the hypothalamic-pituitary-adrenal axis (HPA). Studies examining HPA dynamics peri-operatively are limited and the modulating influence of peri-operatively administered glucocorticoids on that is not well established. This investigation examined alterations in HPA function and the impact of dexamethasone (DEX) administration during the peri-operative period. METHODS: We examined HPA function in 297 patients with normal function who had surgical procedures including pituitary mass resection (n = 191), craniotomy (n = 17) and other thoracic/ abdominal/ pelvic surgeries (n = 89)...
September 1, 2017: Endocrine
https://www.readbyqxmd.com/read/28852635/parental-perception-of-oral-health-related-quality-of-life-of-syrian-refugee-children
#6
Sharat Chandra Pani, Salam Atef Al-Sibai, Akanksha S Rao, Samira Najeebullah Kazimoglu, Hezekiah Adeyemi Mosadomi
AIMS AND OBJECTIVES: The conflict in Syria has resulted in the displacement of over 5 million people, many of whom intend to return home at the cessation of hostilities. Oral health plays a critical role in early childhood and this study aimed to qualitatively and quantitatively assess the oral health-related quality of life (OHRQoL) of these children. MATERIALS AND METHODS: The quantitative assessment of OHRQoL was done using a validated Arabic version of the short-form Parental-Caregiver Perceptions Questionnaire-8 (P-CPQ-8)...
July 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28782499/antitumor-activity-of-%C3%AE-2-himachalen-6-ol-in-colon-cancer-is-mediated-through-its-inhibition-of-the-pi3k-and-mapk-pathways
#7
Hamid E Daaboul, Costantine F Daher, Kikki Bodman-Smith, Robin I Taleb, Wassim N Shebaby, Joelle Boulos, Carole Dagher, Mohamad A Mroueh, Mirvat El-Sibai
Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses in vitro and in vivo anticancer activities. Chemical analysis of DCOE led to the isolation of β-2-himachalen-6-ol (HC) which exhibited potent anticancer activity against colon, breast, brain and skin cancer cells. The present study investigates the anticancer activity of HC against SW1116 colon cancer cell lines, and evaluates its effect in a 1,2-dimethylhydrazine (DMH) colon carcinogenesis black6 mice model. The SW1116 colon cancer cell line was treated with HC (1, 5, 10 and 25 μg/ml) and cell viability was evaluated with WST 1 assay kit...
August 3, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28748239/phototoxicity-of-strained-ru-ii-complexes-is-it-the-metal-complex-or-the-dissociating-ligand
#8
Daniel F Azar, Hassib Audi, Stephanie Farhat, Mirvat El-Sibai, Ralph J Abi-Habib, Rony S Khnayzer
A photochemically dissociating ligand in Ru(bpy)2(dmphen)Cl2 [bpy = 2,2'-bipyridine; dmphen = 2,9-dimethyl-1,10-phenanthroline] was found to be more cytotoxic on the ML-2 Acute Myeloid Leukemia cell line than Ru(bpy)2(H2O)2(2+) and prototypical cisplatin. Our findings illustrate the potential potency of diimine ligands in photoactivatable Ru(ii) complexes.
September 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28715482/impact-of-maternal-body-mass-index-and-gestational-weight-gain-on-neonatal-outcomes-among-healthy-middle-eastern-females
#9
Tatiana Papazian, Georges Abi Tayeh, Darine Sibai, Hala Hout, Imad Melki, Lydia Rabbaa Khabbaz
BACKGROUND: Studies on the relative impact of body mass index in women in childbearing age and gestational weight gain on neonatal outcomes are scarce in the Middle East. OBJECTIVES: The primary objective of this research was to assess the impact of maternal body mass index (BMI) and gestational weight gain (GWG) on neonatal outcomes. The effect of maternal age and folic acid supplementation before and during pregnancy was also examined. SUBJECTS AND METHODS: This is a retrospective cross sectional observational study of 1000 full term deliveries of women enrolled thru the National Collaborative Perinatal Neonatal Network, in Lebanon...
2017: PloS One
https://www.readbyqxmd.com/read/28711573/distribution-and-impact-of-comorbidities-on-survival-and-leukemic-transformation-in-myeloproliferative-neoplasm-associated-myelofibrosis-a-retrospective-cohort-study
#10
Justyna Bartoszko, Tony Panzarella, Caroline Jane McNamara, Anthea Lau, Aaron D Schimmer, Andre C Schuh, Hassan Sibai, Dawn Maze, Karen W L Yee, Rebecca Devlin, Vikas Gupta
BACKGROUND: We sought to describe the distribution and impact of comorbidities on outcomes in patients with myelofibrosis, a disease characterized by aberrant bone marrow function with eventual fibrosis. Comorbidities were scored using the Adult Comorbidity Evaluation-27 (ACE-27) and the Hematopoietic Cell Transplant Comorbidity Index (HCT-CI), in which a score ≥ 3 indicates severe comorbidities. PATIENTS AND METHODS: We conducted a retrospective study of 306 patients with a confirmed diagnosis of myelofibrosis...
June 29, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28708975/short-term-costs-of-preeclampsia-to-the-united-states-health-care-system
#11
Warren Stevens, Tiffany Shih, Devin Incerti, Thanh G N Ton, Henry C Lee, Desi Peneva, George A Macones, Baha M Sibai, Anupam B Jena
BACKGROUND: Preeclampsia is a leading cause of maternal morbidity and mortality and adverse neonatal outcomes. Little is known about the extent of the health and cost burden of preeclampsia in the United States. OBJECTIVE: This study sought to quantify the annual epidemiological and health care cost burden of preeclampsia to both mothers and infants in the United States in 2012. STUDY DESIGN: We used epidemiological and econometric methods to assess the annual cost of preeclampsia in the United States using a combination of population-based and administrative data sets: the National Center for Health Statistics Vital Statistics on Births, the California Perinatal Quality Care Collaborative Databases, the US Health Care Cost and Utilization Project database, and a commercial claims data set...
September 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28697235/preclinical-evaluation-of-spatial-frequency-domain-enabled-wide-field-quantitative-imaging-for-enhanced-glioma-resection
#12
Mira Sibai, Carl Fisher, Israel Veilleux, Jonathan T Elliott, Frederic Leblond, David W Roberts, Brian C Wilson
5-Aminolevelunic acid-induced protoporphyrin IX (PpIX) fluorescence-guided resection (FGR) enables maximum safe resection of glioma by providing real-time tumor contrast. However, the subjective visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to reliably delineating only high-grade tumors that display strong fluorescence. We have previously shown, using a fiber-optic probe, that quantitative assessment using noninvasive point spectroscopic measurements of the absolute PpIX concentration in tissue further improves the accuracy of FGR, extending it to surgically curable low-grade glioma...
July 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28690885/cancer-research-in-the-arab-world-a-review-of-publications-from-seven-countries-between-2000-2013
#13
REVIEW
Randah R Hamadeh, Saif M Borgan, Abla M Sibai
This review aimed to examine trends in cancer research in the Arab world and identify existing research gaps. A search of the MEDLINE® database (National Library of Medicine, Bethesda, Maryland, USA) was undertaken for all cancer-related publications published between January 2000 and December 2013 from seven countries, including Bahrain, Kuwait, Iraq, Lebanon, Morocco, Palestine and Sudan. A total of 1,773 articles were identified, with a significant increase in yearly publications over time (P <0.005)...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28651448/adverse-pregnancy-outcomes-in-deliveries-prior-to-at-and-beyond-39-weeks-low-and-high-risk-women
#14
Hind N Moussa, Susan Hosseini Nasab, Farah H Amro, Jennifer Hoayek, Ziad A Haidar, Sean C Blackwell, Baha M Sibai
BACKGROUND: Hypertensive disorders are associated with maternal and neonatal complications. Though they are more common in women with history of prior preeclampsia, they can occur in uncomplicated pregnancies. OBJECTIVE: To determine the proportion of adverse pregnancy outcomes in deliveries prior to or at ≥39 weeks, in uncomplicated singleton nulliparous women (low-risk), as well as women with history of preeclampsia in a prior gestation (high-risk). STUDY DESIGN: This was a secondary analysis from the multicenter trials of low dose aspirin for preeclampsia prevention in low and high-risk pregnancies...
July 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28648694/removal-notice-to-the-relationship-between-primary-cesarean-delivery-skin-incision-type-and-wound-complications%C3%A2-in%C3%A2-women-with-morbid-obesity-am-j-obstet-gynecol-2014-210-319-e1-4
#15
Caroline C Marrs, Hind N Moussa, Baha M Sibai, Sean C Blackwell
This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been removed at the request of the Editors-in-Chief and Authors. The original publication reported that univariate analysis showed that a vertical skin incision in obese women undergoing Cesarean delivery was associated with a higher odds ratio for wound complications than a transverse skin incision. Multivariable analyses showed a reversal of the association (i...
July 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28595467/remissions-after-third-induction-chemotherapy-for-primary-non-responders-with-acute-myeloid-leukemia-aml-are-uncommon-and-short-lived
#16
Sara Farshchi Zarabi, Steven Chan, Vikas Gupta, Dina Khalaf, Andrzej Lutynski, Mark D Minden, Amr Rostom, Anna Rydlewski, Andre C Schuh, Hassan Sibai, Karen W L Yee, Aaron D Schimmer
No abstract text is available yet for this article.
June 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28575065/does-published-research-on-non-communicable-disease-ncd-in-arab-countries-reflect-ncd-disease-burden
#17
Abla M Sibai, Neil V Singh, Samer Jabbour, Shadi Saleh, Sawsan Abdulrahim, Farah Naja, Soha Yazbek
OBJECTIVES: To review trends in non-communicable (NCD) research output in the Arab region, in terms of quantity and quality, study design, setting and focus. We also examined differences by time and place, and assessed gaps between research output and NCD burden. METHODS: A scoping review of a total of 3,776 NCD-related reports published between 2000 and 2013 was conducted for seven Arab countries. Countries were selected to represent diverse socio-economic development levels in the region: Regression analyses were used to assess trends in publications over time and by country...
2017: PloS One
https://www.readbyqxmd.com/read/28420273/role-of-inflammation-in-the-association-between-the-western-dietary-pattern-and-metabolic-syndrome-among-lebanese-adults
#18
Farah Naja, Nitin Shivappa, Lara Nasreddine, Samer Kharroubi, Leila Itani, Nahla Hwalla, Abla Mehio Sibai, James R Hebert
The aim of this study was to investigate whether inflammation mediates the previously observed direct association between the western dietary pattern (WDP) and metabolic syndrome (MetS) among Lebanese adults. Sociodemographic, lifestyle, dietary pattern scores, anthropometric and biochemical data of 331 adults were used in this study. Inflammation indicators considered were: serum C-reactive protein (CRP) and the dietary inflammatory index (DII). The scores of the WDP were significantly associated with DII (r = ...
April 19, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28400306/can-3-dimensional-power-doppler-indices-improve-the-prenatal-diagnosis%C3%A2-of-a-potentially-morbidly-adherent-placenta-in-patients-with%C3%A2-placenta-previa
#19
Ziad A Haidar, Ramesha Papanna, Baha M Sibai, Nina Tatevian, Oscar A Viteri, Patricia C Vowels, Sean C Blackwell, Kenneth J Moise
BACKGROUND: Traditionally, 2-dimensional ultrasound parameters have been used for the diagnosis of a suspected morbidly adherent placenta previa. More objective techniques have not been well studied yet. OBJECTIVE: The objective of the study was to determine the ability of prenatal 3-dimensional power Doppler analysis of flow and vascular indices to predict the morbidly adherent placenta objectively. STUDY DESIGN: A prospective cohort study was performed in women between 28 and 32 gestational weeks with known placenta previa...
August 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28358020/nmr-based-metabolomics-reveals-alterations-of-electro-acupuncture-stimulations-on-chronic-atrophic-gastritis-rats
#20
Jingjing Xu, Xujuan Zheng, Kian-Kai Cheng, Xiaorong Chang, Guiping Shen, Mi Liu, Yadong Wang, Jiacheng Shen, Yuan Zhang, Qida He, Jiyang Dong, Zongbao Yang
Chronic atrophic gastritis (CAG) is a common gastrointestinal disease which has been considered as precancerous lesions of gastric carcinoma. Previously, electro-acupuncture stimulation has been shown to be effective in ameliorating symptoms of CAG. However the underlying mechanism of this beneficial treatment is yet to be established. In the present study, an integrated histopathological examination along with molecular biological assay, as well as (1)H NMR analysis of multiple biological samples (urine, serum, stomach, cortex and medulla) were employed to systematically assess the pathology of CAG and therapeutic effect of electro-acupuncture stimulation at Sibai (ST 2), Liangmen (ST 21), and Zusanli (ST 36) acupoints located in the stomach meridian using a rat model of CAG...
March 30, 2017: Scientific Reports
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