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https://www.readbyqxmd.com/read/29753357/personal-income-before-and-after-diagnosis-of-multiple-sclerosis
#1
Erik Landfeldt, Anna Castelo-Branco, Axel Svedbom, Emil Löfroth, Andrius Kavaliunas, Jan Hillert
BACKGROUND: Multiple sclerosis (MS) is associated with serious morbidity and labor force absenteeism, but little is known of the long-term impact of the disease on personal income. OBJECTIVES: To assess long-term consequences of MS on personal salary and disposable income. METHODS: Patients with MS in Sweden were identified in a nationwide, disease-specific register and matched with general population controls. We assessed mean annual personal gross salary and disposable income each year before and after index (i...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29747156/maternal-areola-ph-a-chemical-basis-for-mother-infant-recognition
#2
Vincenzo Zanardo, Francesca Volpe, Matteo Parotto, Lara Giliberti, Alphonse Simbi, Lorenzo Severino, Gianluca Straface
BACKGROUND: The human female's areolar region is the point of arrival of a natural progression from birth to breastfeeding continuum, supported by numerous functional features. AIMS: The aim of this study was to look more closely into the areola' skin chemical signals that are uniquely important for mother-infant chemoemission, chemoreception, and breastfeeding continuum. STUDY DESIGN: A dermatological study of the areolae and corresponding breast quadrants was undertaken on 71 healthy, at-term women...
May 7, 2018: Early Human Development
https://www.readbyqxmd.com/read/29706926/modulating-the-oxytocin-system-during-the-perinatal-period-a-new-strategy-for-neuroprotection-of-the-immature-brain
#3
REVIEW
Manuela Zinni, Marina Colella, Aline Rideau Batista Novais, Olivier Baud, Jérôme Mairesse
Oxytocin is a neurohypophysal hormone known for its activity during labor and its role in lactation. However, the function of oxytocin (OTX) goes far beyond the peripheral regulation of reproduction, and the central effects of OTX have been extensively investigated, since it has been recognized to influence the learning and memory processes. OTX has also prominent effects on social behavior, anxiety, and autism. Interaction between glucocorticoids, OTX, and maternal behavior may have long-term effects on the developmental program of the developing brain subjected to adverse events during pre and perinatal periods...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29692477/use-of-plan-do-study-act-cycles-to-decrease-incidence-of-neonatal-hypothermia-in-the-labor-room
#4
Subhash Chandra Shaw, Amit Devgan, Sushila Anila, Neha Anushree, Himadri Debnath
Background: Body temperature of a neonate continues to be under-documented, under-recognized, and under-managed, even though studies have shown that neonatal hypothermia increases mortality and morbidity. We aimed to reduce neonatal hypothermia (body temperature <36.5 °C) at 1 h following normal vaginal delivery in term and late preterm neonates in delivery room from 50% at baseline to less than 10% by 6 weeks. Methods: We implemented a quality improvement (QI) initiative using the rapid-cycle Plan-Do-Study-Act approach (PDSA) improvement model and the project was conducted from 15 Jan 2017 to 25 Feb 2017...
April 2018: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/29593048/effect-of-short-term-art-interruption-on-levels-of-integrated-hiv-dna
#5
Zachary Strongin, Radwa Sharaf, D Jake VanBelzen, Jeffrey M Jacobson, Elizabeth Connick, Paul Volberding, Daniel J Skiest, Rajesh T Gandhi, Daniel R Kuritzkes, Una O'Doherty, Jonathan Z Li
Analytic treatment interruption (ATI) studies are required to evaluate strategies aimed at achieving ART-free HIV remission, but the impact of ATI on the viral reservoir remains unclear. We validated a DNA size selection-based assay for measuring levels of integrated HIV DNA and applied it to assess the effects of short-term ATI on the HIV reservoir. Samples from participants from four AIDS Clinical Trials Group (ACTG) ATI studies were assayed for integrated HIV DNA levels. Cryopreserved PBMCs were obtained for 12 participants with available samples pre-ATI and approximately 6 months after ART resumption...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29566659/accelerating-newborn-survival-in-ghana-through-a-low-dose-high-frequency-health-worker-training-approach-a-cluster-randomized-trial
#6
Patricia P Gomez, Allyson R Nelson, Amos Asiedu, Etta Addo, Dora Agbodza, Chantelle Allen, Martha Appiagyei, Cynthia Bannerman, Patience Darko, Julia Duodu, Fred Effah, Hannah Tappis
BACKGROUND: Newborn deaths comprise nearly half of under-5 deaths in Ghana, despite the fact that skilled birth attendants (SBAs) are present at 68% of births, which implies that evidence-based care during labor, birth and the immediate postnatal period may be deficient. We assessed the effect of a low-dose, high-frequency (LDHF) training approach on long-term evidence-based skill retention among SBAs and impact on adverse birth outcomes. METHODS: From 2014 to 2017, we conducted a cluster-randomized trial in 40 hospitals in Ghana...
March 22, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29559801/vertical-transmission-of-group-b-streptococcus-and-associated-factors-among-pregnant-women-a-cross-sectional-study-eastern-ethiopia
#7
Tesfaye Assebe Yadeta, Alemayehu Worku, Gudina Egata, Berhanu Seyoum, Dadi Marami, Yemane Berhane
Background: Vertically transmitted group B Streptococcus (GBS) causes fetal and neonatal infections. However, there is limited information on the vertical transmission of GBS in low-income countries. This study, therefore, aimed to determine the rate of vertical transmission of GBS and associated factors among pregnant women in Eastern Ethiopia. Subjects and methods: A cross-sectional, facility-based study was conducted among pregnant women in Harar town, Eastern Ethiopia, from June to October, 2016...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29516643/labor-induction-versus-expectant-management-at-early-term-in-pregnancies-with-second-trimester-elevated-human-chorionic-gonadotropin-or-alpha-fetoprotein
#8
Enav Yefet, Olga Kuzmin, Naama Schwartz, Flora Basson, Zohar Nachum
AIM: Elevated human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) have been linked to placental dysfunction and associated morbidities. We aimed to compare the induction of labor with expectant management at term in those pregnancies for the prevention of neonatal and maternal morbidities. METHODS: Women with second trimester HCG ≥ 2 and/or AFP ≥ 2 multiples of the median, without additional maternal or fetal complications, from their 38th gestational week were offered the choice of labor induction or expectant management...
March 8, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29501074/placental-mitochondrial-biogenesis-and-function-was-slightly-changed-by-gestational-hypercholesterolemia-in-full-term-pregnant-women
#9
Z-Y Le, S Dong, R Zhang, X-P Cai, A Gao, R Xiao, H-L Yu
It was reported that high blood cholesterol levels increased the susceptibility to mitochondrial dysfunction. This study hypothesized that the gestational hypercholesterolemia (HC) could induce the mitochondrial dysfunction in term human placenta. The eligible pregnant women were recruited from Xuanwu Hospital in Beijing during their first prenatal visit (before their 10th week of pregnancy). In total, 19 pregnant women whose serum total cholesterol levels were higher than 7.25 mm at third trimester (measured at 36-38 weeks) were selected as gestational HC...
March 4, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29500186/monitoring-uterine-contractility-in-mice-using-a-transcervical-intrauterine-pressure-catheter
#10
Michael F Robuck, Christine M O'Brien, Kelsi M Knapp, Sheila D Shay, James D West, J M Newton, James C Slaughter, Bibhash C Paria, Jeff Reese, Jennifer L Herington
In mouse models used to study parturition or pre-clinical therapeutic testing, measurement of uterine contractions is limited to either ex vivo isometric tension or operative intrauterine pressure (IUP). The goal of this study was to: (1) develop a method for transcervical insertion of a pressure catheter to measure in vivo intrauterine contractile pressure during mouse pregnancy, (2) determine whether this method can be utilized numerous times in a single mouse pregnancy without affecting the timing of delivery or fetal outcome and (3) compare the in vivo contractile activity between mouse models of term and preterm labor (PTL)...
May 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29433462/early-onset-neonatal-hyperkalemia-associated-with-maternal-hypermagnesemia-a-case-report
#11
Kenichi Tanaka, Hiroko Mori, Rieko Sakamoto, Shirou Matsumoto, Hiroshi Mitsubuchi, Kimitoshi Nakamura, Masanori Iwai
BACKGROUND: Neonatal nonoliguric hyperkalemia (NOHK) is a metabolic abnormality that occurs in extremely premature neonates at approximately 24 h after birth and is mainly due to the immature functioning of the sodium (Na+ )/potassium (K+ ) pump. Magnesium sulfate is frequently used in obstetrical practice to prevent preterm labor and to treat preeclampsia; this medication can also cause hypermagnesemia and hyperkalemia by a mechanism that is different from that of NOHK. Herein, we report the first case of very early-onset neonatal hyperkalemia induced by maternal hypermagnesemia...
February 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29422706/women-s-age-at-first-marriage-and-long-term-economic-empowerment-in-egypt
#12
Kathryn M Yount, AliceAnn Crandall, Yuk Fai Cheong
Sustainable Development Goal (SDG) 5 calls on nations to promote gender equality and to empower women and girls. SDG5 also recognizes the value of women's economic empowerment, entailing equal rights to economic resources and full participation at all levels in economic decisions. Also according to SDG5, eliminating harmful practices-such as child marriage before age 18-is a prerequisite for women's economic empowerment. Using national data for 4,129 married women 15-43 years who took part in the Egypt Labor Market Panel Survey (ELMPS 1998-2012), we performed autoregressive, cross-lagged panel analyses to assess whether women's first marriage in adulthood (at 18 years or older, as reported in 2006), was positively associated with their long-term post-marital economic empowerment, measured as their engagement in market work and latent family economic agency in 2012...
February 2018: World Development
https://www.readbyqxmd.com/read/29374256/screening-a-small-molecule-library-to-identify-inhibitors-of-nf-%C3%AE%C2%BAb-inducing-kinase-and-pro-labor-genes-in-human-placenta
#13
Bingbing Wang, Nataliya Parobchak, Adriana Martin, Max Rosen, Lumeng Jenny Yu, Mary Nguyen, Kseniya Gololobova, Todd Rosen
The non-canonical NF-κB signaling (RelB/p52) pathway drives pro-labor genes in the human placenta, including corticotropin-releasing hormone (CRH) and cyclooxygenase-2 (COX-2), making this a potential therapeutic target to delay onset of labor. Here we sought to identify small molecule compounds from a pre-existing chemical library of orally active drugs that can inhibit this NF-κB signaling, and in turn, human placental CRH and COX-2 production. We used a cell-based assay coupled with a dual-luciferase reporter system to perform an in vitro screening of a small molecule library of 1,120 compounds for inhibition of the non-canonical NF-κB pathway...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325263/-analysis-of-2-204-stillbirths-in-11-hospitals-of-guangdong-province
#14
L Yu, M Tang, X H Fan, H M Du, H Tang, P Chen, S L Xing, C H Su, D J Chen
Objective: To analyze the incidence and causes of stillbirth in 11 hospitals of Guangdong province, and to explore the appropriate interventions. Methods: Clinical data of stillbirth in 11 hospitals of Guangdong province were collected from January 2014 to December 2016. The gestational weeks, causes, maternal conditions and other factors were analyzed. Results: (1) From 2014 to 2016, 103 472 newborns were delivered in the 11 hospitals, and the number of stillbirth was 2 204, with the incidence of 2.13%. Among them, 0...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29304769/a-comparison-of-misoprostol-vaginal-insert-and-misoprostol-vaginal-tablets-for-induction-of-labor-in-nulliparous-women-a-retrospective-cohort-study
#15
Kjersti Engen Marsdal, Ingvil Krarup Sørbye, Lise C Gaudernack, Mirjam Lukasse
BACKGROUND: Since Misoprostol Vaginal Insert (MVI - Misodel ®) was approved for labor induction in Europe in 2013, to date, no study has been published comparing MVI to Misoprostol vaginal tablets (MVT). The aim of this study, performed as part of a quality improvement project, was to compare the efficacy and safety of 200 μg MVI versus 25 μg MVT for labor induction in nulliparous women. METHODS: This retrospective cohort study included 171 nulliparous singleton term deliveries induced with MVI (n = 85) versus MVT (n = 86) at Oslo University Hospital Rikshospitalet, Norway, from November 2014 to December 2015...
January 5, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29286493/twenty-five-years-of-the-national-academy-of-medical-sciences-of-ukraine-progress-and-priorities-for-future-of-radiation-medicine-and-biology
#16
D Bazyka
After the creation of the Academy of Medical Sciences of Ukraine in 1993 the Research Center for Radiation Medicine was among the first institutions to join the Academy (fig. 1). Estab lishing the Academy was among the first steps of the independent Ukrainian government and aimed to provide a high level health care for population. It was extremely needed for the minimization of Chornobyl medical consequences. This choice was related to a growing recognition of the scientific research in fulfilling the Сenter's mission - study of the effects of low dose radiation on human body and radiation protection of the exposed population...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29272996/spontaneous-first-trimester-miscarriage-rates-per-woman-among-parous-women-with-1-or-more-pregnancies-of-24-weeks-or-more
#17
Judy Slome Cohain, Rina E Buxbaum, David Mankuta
BACKGROUND: The purpose of this study was to quantify spontaneous first trimester miscarriage rates per woman among parous women. A vast amount of data has accumulated regarding miscarriage rates per recognized pregnancy as well as about recurrent miscarriage. This is the second study of miscarriage rates per woman in a parous population and the first study of recurrent and non-recurrent, spontaneous first trimester miscarriage rates per woman in a large parous population. METHODS: Extraction of the following variables from all delivery room admissions from both Hadassah Medical Centers in Jerusalem Israel, 2004-2014: # of first trimester spontaneous miscarriages, # live births; # living children; age on admission, pre-pregnancy height and weight, any smoking this pregnancy, any alcohol or drug abuse this pregnancy, blood type, history of ectopic pregnancy, history of cesarean surgery (CS) and use of any fertility treatment(s)...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29211491/complications-and-care-related-to-pregnancy-labor-and-delivery-among-active-component-service-women-u-s-armed-forces-2012-2016
#18
Shauna Stahlman, Catherine T Witkop, Leslie L Clark, Stephen B Taubman
Diagnoses of "complications of pregnancy, childbirth, and the puerperium" include both morbid complications and indications for routine care of pregnant women. During 2012-2016, a total of 55,601 U.S. service members with live births (n=63,879) had 657,060 medical encounters with primary diagnoses of "pregnancy complications." The most frequent diagnoses were "other" specified conditions complicating pregnancy, childbirth, or the puerperium. Numbers of medical encounters with a primary (first-listed) diagnosis of any pregnancy-related complication or indication for care decreased marginally each year between 2012 (n=178,703) and 2016 (n=146,282)...
November 2017: MSMR
https://www.readbyqxmd.com/read/29201427/predictors-of-long-acting-and-permanent-contraceptive-methods-utilization-among-women-in-rural-north-shoa-ethiopia
#19
Fantahun Ayenew Mekonnen, Wassie Negash Mekonnen, Solomon Hailemeskel Beshah
Background: According to available evidence, one in three married women in Ethiopia tends to avoid multiple children. On the other hand, women using Long Acting and Permanent Contraceptive Methods (LAPMs) are just 5 %. So, we aimed at identifying the factors associated with the utilization of LAPMs. Methods: We conducted a community based unmatched case control study among married women living in the rural areas of North Shoa zone, Ethiopia, in March 2015. The cases were married women using LAPMs, while controls were married women who were using modern short term methods...
2017: Contraception and Reproductive Medicine
https://www.readbyqxmd.com/read/29182088/perinatal-maternal-mortality-in-sickle-cell-anemia-two-case-reports-and-review-of-the-literature
#20
Sanaa Rizk, Elizabeth D Pulte, David Axelrod, Samir K Ballas
As outcomes of patients with sickle cell anemia improve and survival into adulthood with good quality of life and expectation of long-term survival becomes more common, challenges have developed, including issues related to reproduction. Pregnancy is frequently complicated in patients with sickle cell anemia with mortality up to 4.0%. Here we report maternal perinatal mortality in two women with sickle cell anemia who died post-partum due to acute chest syndrome (ACS), caused by bone marrow fat embolism and review the literature pertinent to this subject...
July 2017: Hemoglobin
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