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Pre-term labor

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https://www.readbyqxmd.com/read/28286810/epidemiology-and-related-risk-factors-of-preterm-labor-as-an-obstetrics-emergency
#1
Ali Asghar Halimi Asl, Saeed Safari, Mohsen Parvareshi Hamrah
INTRODUCTION: Preterm birth is still a major health problem throughout the world, which results in 75% of neonatal mortality. Preterm labor not only inflicts financial and emotional distress, it may also lead to permanent disability. The present study was conducted to determine the related risk factors and preventive measures of preterm labor. METHODS: This retrospective cross-sectional study assessed all preterm labors, as well as an equal number of term labors, during seven years, at an educational hospital...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28277909/late-preterm-and-early-term-when-to-induce-a-growth-restricted-fetus-a-population-based-study
#2
Alex Rabinovich, Tehila Tsemach, Lena Novack, Moshe Mazor, Tal Rafaeli-Yehudai, Orna Staretz-Chacham, Ruth Beer Weisel, Vered Klaitman-Mayer, Salvatore A Mastrolia, Offer Erez
PURPOSE: 1) Compare fetal and neonatal morbidity and mortality associated with induction of labor (IOL) vs. expectant management (EM) in women with isolated fetal growth restriction (FGR) between [Formula: see text] - [Formula: see text] weeks; 2) Determine optimal gestational age for delivery of such fetuses. MATERIALS AND METHODS: A retrospective population based cohort study of 2232 parturients with isolated FGR, including two groups: 1) IOL (n = 1428); 2) EM (n= 804)...
March 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28276165/distribution-of-invariant-natural-killer-t-cells-and-dendritic-cells-in-late-pre-term-birth-without-acute-chorioamnionitis
#3
Yasuyuki Negishi, Yoshio Shima, Toshiyuki Takeshita, Hidemi Takahashi
PROBLEM: Acute chorioamnionitis (aCAM) is an important cause of pre-term birth. However, little is known about the pathogenesis of late pre-term birth without aCAM that was the most common category of pre-term birth. Here we analyze the kinetics of immune cells obtained from the decidua of women with late pre-term births with and without aCAM. METHOD OF STUDY: Deciduas were obtained from women who underwent labor with late pre-term birth without aCAM (PB-n/aCAM) or with aCAM (PB-w/aCAM)...
March 9, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28209491/the-preterm-cervix-reveals-a-transcriptomic-signature-in-the-presence-of-premature-prelabor-rupture-of-membranes
#4
Sofia Makieva, Aurelija Dubicke, Sara F Rinaldi, Emma Fransson, Gunvor Ekman-Ordeberg, Jane E Norman
BACKGROUND: Premature prelabor rupture of fetal membranes accounts for 30% of all premature births and is associated with detrimental long-term infant outcomes. Premature cervical remodeling, facilitated by matrix metalloproteinases, may trigger rupture at the zone of the fetal membranes overlying the cervix. The similarities and differences underlying cervical remodeling in premature prelabor rupture of fetal membranes and spontaneous preterm labor with intact membranes are unexplored...
February 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28012455/maternal-obesity-alters-brain-derived-neurotrophic-factor-bdnf-signaling-in-the-placenta-in-a-sexually-dimorphic-manner
#5
Calais S Prince, Alina Maloyan, Leslie Myatt
INTRODUCTION: Obesity is a major clinical problem in obstetrics being associated with adverse pregnancy outcomes and fetal programming. Brain derived neurotrophic factor (BDNF), a validated miR-210 target, is necessary for placental development, fetal growth, glucose metabolism, and energy homeostasis. Plasma BDNF levels are reduced in obese individuals; however, placental BDNF has yet to be studied in the context of maternal obesity. In this study, we investigated the effect of maternal obesity and sexual dimorphism on placental BDNF signaling...
January 2017: Placenta
https://www.readbyqxmd.com/read/27855185/aberrant-expression-of-timp-2-and-pbef-genes-in-the-placentae-of-cloned-mice-due-to-epigenetic-reprogramming-error
#6
Hong Rye Kim, Jae Eun Lee, Reza Kheirkhahi Oqani, So Yeon Kim, Teruhiko Wakayama, Chong Li, Su Jin Sa, Je Seok Woo, Dong Il Jin
Cloned mice derived from somatic or ES cells show placental overgrowth (placentomegaly) at term. We had previously analyzed cloned and normal mouse placentae by using two-dimensional gel electrophoresis and mass spectrometry to identify differential protein expression patterns. Cloned placentae showed upregulation of tissue inhibitor of metalloproteinase-2 (TIMP-2), which is involved in extracellular matrix degradation and tissue remodeling, and downregulation of pre-B cell colony enhancing factor 1 (PBEF), which inhibits apoptosis and induces spontaneous labor...
2016: PloS One
https://www.readbyqxmd.com/read/27776846/-prevention-of-preterm-birth-complications-by-antenatal-corticosteroid-administration
#7
T Schmitz
OBJECTIVE: To evaluate short- and long-term benefits and risks associated with antenatal administration of a single course of corticosteroids and the related strategies: multiple and rescue courses. METHODS: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: Antenatal administration of a single course of corticosteroids before 34 weeks of gestation is associated in the neonatal period with a significant reduction of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC) and death (LE1), and in possibly childhood with a reduction of cerebral palsy and increased psychomotor development index and intact survival (LE3)...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/27766978/prevalence-and-risk-factors-related-to-preterm-birth-in-brazil
#8
Maria do Carmo Leal, Ana Paula Esteves-Pereira, Marcos Nakamura-Pereira, Jacqueline Alves Torres, Mariza Theme-Filha, Rosa Maria Soares Madeira Domingues, Marcos Augusto Bastos Dias, Maria Elizabeth Moreira, Silvana Granado Gama
BACKGROUND: The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a significant public health challenge because of the higher levels of morbidity and mortality and long-term health effects associated with preterm birth. This study describes and quantifies factors affecting spontaneous and provider-initiated preterm birth in Brazil. METHODS: Data are from the 2011-2012 "Birth in Brazil" study, which used a national population-based sample of 23,940 women...
October 17, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27718494/the-value-of-ultrasound-measurement-of-cervical-length-and-parity-in-prediction-of-cesarean-section-risk-in-term-premature-rupture-of-membranes-and-unfavorable-cervix
#9
Nada Aracic, Ivica Stipic, Ivana Jakus Alujevic, Petar Poljak, Mario Stipic
AIM: To evaluate the influence of cervical length (CL) and parity as prediction factors for assessment of cesarean section (CS) risk in women with premature rupture of membranes (PROM) at term and unfavorable cervix, undergoing induction of labor (IOL) with dinoprostone intracervical gel. METHODS: A prospective study involved 50 nulliparous and 51 multiparous women admitted for IOL. Pre-induction CL was measured and delivery outcomes were recorded. RESULTS: Nulliparous women were younger than the multiparous (26...
January 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27690725/histological-chorioamnionitis-in-preterm-prelabor-rupture-of-the-membranes-is-associated-with-increased-expression-of-galectin-3-by-amniotic-epithelium
#10
Ivana Stefanoska, Jasmina Tadić, Aleksandra Vilotić, Milica Jovanović Krivokuća, Tamara Abu Rabi, Ljiljana Vićovac
PURPOSE: Gal-3, which can regulate immune responses upon infection and inflammation, was not studied so far in intrauterine infection leading to preterm prelabor rupture of the membranes (PPROM), although gal-1 was reported to be implicated in the process. Gal-3 mRNA and protein expression in amnion and its changes during histological chorioamnionitis were studied here. MATERIALS AND METHODS: Fetal membranes were obtained from women with PPROM with (n =15) and without histological chorioamnionitis (n =15) during second and third trimester...
October 25, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27680785/a4-egfl7-in-placenta-trophoblast-and-endothelial-cells-implications-in-the-pathogenesis-of-pre-eclampsia
#11
M Massimiani, S Salvi, D Piccirilli, L Vecchione, S Moresi, S Ferrazzani, H Stuhlmann, L Campagnolo
INTRODUCTION: Placental development requires invasion and differentiation of trophoblast cells, together with coordinated fetal vasculogenesis and maternal vascular remodeling. During placental development, extravillous cytotrophoblasts invade the uterine spiral arteries of the decidua and myometrium. These invasive cytotrophoblasts replace the endothelial layer of the maternal spiral arteries, transforming them from high-resistance vessels into large-caliber capacitance vessels capable of adequately nourishing the fetus...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27664809/finding-lost-genes-in-gwas-via-integrative-omics-analysis-reveals-novel-sub-networks-associated-with-preterm-birth
#12
Douglas Brubaker, Yu Liu, Junye Wang, Huiqing Tan, Ge Zhang, Bo Jacobsson, Louis Muglia, Sam Mesiano, Mark R Chance
Maternal genome influences associate with up to 40% of spontaneous preterm births (PTB). Multiple genome wide association studies (GWAS) have been completed to identify genetic variants associated with PTB. Disappointingly, no highly significant SNPs have replicated in independent cohorts so far. We developed an approach combining protein-protein interaction (PPI) network data with tissue specific gene expression data to "find" SNPs of modest significance to identify candidate genes of functional importance that would otherwise be overlooked...
September 23, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27634471/technology-assisted-stroke-rehabilitation-in-mexico-a-pilot-randomized-trial-comparing-traditional-therapy-to-circuit-training-in-a-robot-technology-assisted-therapy-gym
#13
Karla Bustamante Valles, Sandra Montes, Maria de Jesus Madrigal, Adan Burciaga, María Elena Martínez, Michelle J Johnson
BACKGROUND: Stroke rehabilitation in low- and middle-income countries, such as Mexico, is often hampered by lack of clinical resources and funding. To provide a cost-effective solution for comprehensive post-stroke rehabilitation that can alleviate the need for one-on-one physical or occupational therapy, in lower and upper extremities, we proposed and implemented a technology-assisted rehabilitation gymnasium in Chihuahua, Mexico. The Gymnasium for Robotic Rehabilitation (Robot Gym) consisted of low- and high-tech systems for upper and lower limb rehabilitation...
2016: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/27529696/leukocyte-lysis-and-cytokine-induction-by-the-human-sexually-transmitted-parasite-trichomonas-vaginalis
#14
Frances Mercer, Fitz Gerald I Diala, Yi-Pei Chen, Brenda M Molgora, Shek Hang Ng, Patricia J Johnson
Trichomonas vaginalis (Tv) is an extracellular protozoan parasite that causes the most common non-viral sexually transmitted infection: trichomoniasis. While acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased HIV susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. Heightened inflammation resulting from Tv infection could account for these complications. Effective cellular immune responses to Tv have not been characterized, and re-infection is common, suggesting a dysfunctional adaptive immune response...
August 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27501191/placental-growth-measures-in-relation-to-birth-weight-in-a-latin-american-population
#15
Carlos Grandi, Angélica Veiga, Nancy Mazzitelli, Ricardo de Carvalho Cavalli, Viviane Cardoso
Introduction The placenta, translates how the fetus experiences the maternal environment and is a principal influence on birth weight (BW). Objective To explore the relationship between placental growth measures (PGMs) and BW in a public maternity hospital. Methods Observational retrospective study of 870 singleton live born infants at Hospital Maternidad Sardá, Universidad de Buenos Aires, Argentina, between January 2011 and August 2012 with complete data of PGMs. Details of history, clinical and obstetrical maternal data, labor and delivery and neonatal outcome data, including placental measures derived from the records, were evaluated...
August 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27450900/elevated-c-reactive-protein-levels-in-histological-chorioamnionitis-at-term-impact-of-funisitis-on-term-neonates
#16
Taiki Samejima, Kimihiro Takechi
OBJECTIVE: To compare clinical features and inflammatory effects for mothers and newborns between cases with or without funisitis among histlogical chorioamnionitis (HCA) at term. METHODS: We recruited 42 patients who were diagnosed with HCA at term. The women were classified into group HCA1/2 (HCA without funisitis, n = 22) and group HCA3 (HCA with funisitis, n = 20). Medical records and cardiotocograms were retrospectively reviewed to analyze predelivery maternal signs, abnormal FHR patterns, and neonatal outcomes...
August 18, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27298523/correlation-of-vitamin-d-levels-in-term-normotensive-and-pre-eclamptic-patients-in-labor
#17
Taru Gupta, Sonika Wahi, Nupur Gupta, Sarika Arora, Sangeeta Gupta, Pushpa Bhatia
OBJECTIVE: To evaluate maternal vitamin D levels in term normotensive and preeclamptic patients in labor and to assess additional factors such as maternal and cord blood levels of calcium, phosphorus, parathormone, and alkaline phosphatase and associated factors such as BMI, birth weight, and mode of delivery. METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi, India from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each)...
June 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27054845/influence-of-gestational-weight-gain-and-bmi-on-cesarean-delivery-risk-in-adolescent-pregnancies
#18
M E Beaudrot, J A Elchert, E A DeFranco
OBJECTIVE: Obesity and excessive gestational weight gain (GWG) increase cesarean delivery (CD) risk; however, their influence on teen pregnancies is less clear. We describe the influence of GWG and pre-pregnancy body mass index (BMI) on primary CD (PCD) risk in adolescent compared with adult pregnancies. STUDY DESIGN: Population-based cohort study of Ohio births (2006 to 2012), n=1 034 552. Analyses were limited to 251 398 singleton live births in term (37 to 42 weeks) primiparas...
August 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27021576/maternal-and-perinatal-outcomes-of-pregnancies-in-women-with-cystic-fibrosis-a-single-centre-case-control-study
#19
Aude Girault, Julie Blanc, Vanessa Gayet, François Goffinet, Dominique Hubert
BACKGROUND: Due to increased survival, more women with cystic fibrosis become pregnant. However, studies on the specificities of pregnancy in CF versus healthy women are lacking. METHODS: In this retrospective case-control study, we compared the maternal and perinatal outcomes of 33 pregnancies in CF women who delivered in our maternity ward from December 2000 to December 2013 and were matched to 66 controls. RESULTS: The median term of delivery was similar in cases and controls (38...
April 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/26915924/gynecologic-and-obstetric-consequences-of-obesity-in-adolescent-girls
#20
Leticia Elizondo-Montemayor, Claudia Hernández-Escobar, Eduardo Lara-Torre, Bianca Nieblas, Merith Gómez-Carmona
In the past few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive for a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, during adolescence and also later in life...
February 22, 2016: Journal of Pediatric and Adolescent Gynecology
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