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Pre-term labor

Maria do Carmo Leal, Ana Paula Esteves-Pereira, Marcos Nakamura-Pereira, Jacqueline Alves Torres, Mariza Theme-Filha, Rosa Maria Soares Madeira Domingues, Marcos Augusto Bastos Dias, Maria Elizabeth Moreira, Silvana Granado Gama
BACKGROUND: The rate of preterm birth has been increasing worldwide, including in Brazil. This constitutes a significant public health challenge because of the higher levels of morbidity and mortality and long-term health effects associated with preterm birth. This study describes and quantifies factors affecting spontaneous and provider-initiated preterm birth in Brazil. METHODS: Data are from the 2011-2012 "Birth in Brazil" study, which used a national population-based sample of 23,940 women...
October 17, 2016: Reproductive Health
Nada Aracic, Ivica Stipic, Ivana Jakus Alujevic, Petar Poljak, Mario Stipic
AIM: To evaluate the influence of cervical length (CL) and parity as prediction factors for assessment of cesarean section (CS) risk in women with premature rupture of membranes (PROM) at term and unfavorable cervix, undergoing induction of labor (IOL) with dinoprostone intracervical gel. METHODS: A prospective study involved 50 nulliparous and 51 multiparous women admitted for IOL. Pre-induction CL was measured and delivery outcomes were recorded. RESULTS: Nulliparous women were younger than the multiparous (26...
October 8, 2016: Journal of Perinatal Medicine
Ivana Stefanoska, Jasmina Tadić, Aleksandra Vilotić, Milica Jovanović Krivokuća, Tamara Abu Rabi, Ljiljana Vićovac
PURPOSE: Gal-3, which can regulate immune responses upon infection and inflammation, was not studied so far in intrauterine infection leading to pre-term pre-labor rupture of the membranes (PPROM), although gal-1 was reported to be implicated in the process. Gal-3 mRNA and protein expression in amnion and its changes during histological chorioamnionitis were studied here. MATERIALS AND METHODS: Fetal membranes were obtained from women with PPROM with (n =15) and without histological chorioamnionitis (n =15) during second and third trimester...
October 3, 2016: Journal of Maternal-fetal & Neonatal Medicine
M Massimiani, S Salvi, D Piccirilli, L Vecchione, S Moresi, S Ferrazzani, H Stuhlmann, L Campagnolo
INTRODUCTION: Placental development requires invasion and differentiation of trophoblast cells, together with coordinated fetal vasculogenesis and maternal vascular remodeling. During placental development, extravillous cytotrophoblasts invade the uterine spiral arteries of the decidua and myometrium. These invasive cytotrophoblasts replace the endothelial layer of the maternal spiral arteries, transforming them from high-resistance vessels into large-caliber capacitance vessels capable of adequately nourishing the fetus...
August 2016: Journal of Maternal-fetal & Neonatal Medicine
Douglas Brubaker, Yu Liu, Junye Wang, Huijing Tan, Ge Zhang, Bo Jacobsson, Louis Muglia, Sam Mesiano, Mark R Chance
Maternal genome influences associate with up to 40% of spontaneous preterm births (PTB). Multiple genome wide association studies (GWAS) have been completed to identify genetic variants associated with PTB. Disappointingly, no highly significant SNPs have replicated in independent cohorts so far. We developed an approach combining protein-protein interaction (PPI) network data with tissue specific gene expression data to "find" SNPs of modest significance to identify candidate genes of functional importance that would otherwise be overlooked...
September 23, 2016: Human Molecular Genetics
Karla Bustamante Valles, Sandra Montes, Maria de Jesus Madrigal, Adan Burciaga, María Elena Martínez, Michelle J Johnson
BACKGROUND: Stroke rehabilitation in low- and middle-income countries, such as Mexico, is often hampered by lack of clinical resources and funding. To provide a cost-effective solution for comprehensive post-stroke rehabilitation that can alleviate the need for one-on-one physical or occupational therapy, in lower and upper extremities, we proposed and implemented a technology-assisted rehabilitation gymnasium in Chihuahua, Mexico. The Gymnasium for Robotic Rehabilitation (Robot Gym) consisted of low- and high-tech systems for upper and lower limb rehabilitation...
2016: Journal of Neuroengineering and Rehabilitation
Frances Mercer, Fitz Gerald I Diala, Yi-Pei Chen, Brenda M Molgora, Shek Hang Ng, Patricia J Johnson
Trichomonas vaginalis (Tv) is an extracellular protozoan parasite that causes the most common non-viral sexually transmitted infection: trichomoniasis. While acute symptoms in women may include vaginitis, infections are often asymptomatic, but can persist and are associated with medical complications including increased HIV susceptibility, infertility, pre-term labor, and higher incidence of cervical cancer. Heightened inflammation resulting from Tv infection could account for these complications. Effective cellular immune responses to Tv have not been characterized, and re-infection is common, suggesting a dysfunctional adaptive immune response...
August 2016: PLoS Neglected Tropical Diseases
Carlos Grandi, Angélica Veiga, Nancy Mazzitelli, Ricardo de Carvalho Cavalli, Viviane Cardoso
Introduction The placenta, translates how the fetus experiences the maternal environment and is a principal influence on birth weight (BW). Objective To explore the relationship between placental growth measures (PGMs) and BW in a public maternity hospital. Methods Observational retrospective study of 870 singleton live born infants at Hospital Maternidad Sardá, Universidad de Buenos Aires, Argentina, between January 2011 and August 2012 with complete data of PGMs. Details of history, clinical and obstetrical maternal data, labor and delivery and neonatal outcome data, including placental measures derived from the records, were evaluated...
August 2016: Revista Brasileira de Ginecologia e Obstetrícia
Taiki Samejima, Kimihiro Takechi
OBJECTIVE: To compare clinical features and inflammatory effects for mothers and newborns between cases with or without funisitis among Histlogical chorioamnionitis (HCA) at term. METHODS: We recruited 42 patients who were diagnosed with HCA at term. The women were classified into group HCA1/2 (HCA without funisitis, n = 22) and group HCA3 (HCA with funisitis, n = 20). Medical records and cardiotocograms were retrospectively reviewed to analyze pre-delivery maternal signs, abnormal FHR patterns, and neonatal outcomes...
July 22, 2016: Journal of Maternal-fetal & Neonatal Medicine
Taru Gupta, Sonika Wahi, Nupur Gupta, Sarika Arora, Sangeeta Gupta, Pushpa Bhatia
OBJECTIVE: To evaluate maternal vitamin D levels in term normotensive and preeclamptic patients in labor and to assess additional factors such as maternal and cord blood levels of calcium, phosphorus, parathormone, and alkaline phosphatase and associated factors such as BMI, birth weight, and mode of delivery. METHOD: This was a case control study carried out in Department of Obstetrics and Gynaecology, ESIC-PGIMSR, New Delhi, India from August 2012-April 2014. A total of 100 patients were divided into two equal groups (control and study groups of 50 each)...
June 2016: Journal of Obstetrics and Gynaecology of India
M E Beaudrot, J A Elchert, E A DeFranco
OBJECTIVE: Obesity and excessive gestational weight gain (GWG) increase cesarean delivery (CD) risk; however, their influence on teen pregnancies is less clear. We describe the influence of GWG and pre-pregnancy body mass index (BMI) on primary CD (PCD) risk in adolescent compared with adult pregnancies. STUDY DESIGN: Population-based cohort study of Ohio births (2006 to 2012), n=1 034 552. Analyses were limited to 251 398 singleton live births in term (37 to 42 weeks) primiparas...
August 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Aude Girault, Julie Blanc, Vanessa Gayet, François Goffinet, Dominique Hubert
BACKGROUND: Due to increased survival, more women with cystic fibrosis become pregnant. However, studies on the specificities of pregnancy in CF versus healthy women are lacking. METHODS: In this retrospective case-control study, we compared the maternal and perinatal outcomes of 33 pregnancies in CF women who delivered in our maternity ward from December 2000 to December 2013 and were matched to 66 controls. RESULTS: The median term of delivery was similar in cases and controls (38...
April 2016: Respiratory Medicine
Leticia Elizondo-Montemayor, Claudia Hernández-Escobar, Eduardo Lara-Torre, Bianca Nieblas, Merith Gómez-Carmona
In the last few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well-recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive to a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, both, during adolescence and later in life...
February 22, 2016: Journal of Pediatric and Adolescent Gynecology
Carolin Besenboeck, Silvija Cvitic, Uwe Lang, Gernot Desoye, Christian Wadsack
The phospholipase A2 (PLA2) family is a very diverse group of enzymes, all serving in the cleavage of phospholipids, thereby releasing high amounts of arachidonic acid (AA) and lysophospholipids. AA serves as a substrate for prostaglandin production, which is of special importance in pregnancy for the onset of parturition. Novel research demonstrates that PLA2 action affects the immune response of the mother toward the child and is therefore probably implied in the tolerance of the fetus and prevention of miscarriage...
June 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
Sharon Kay, Taruna Madan
Surfactant associated protein D (SFTPD, also known as SP-D), a pattern recognition molecule, is an integral component of the mucosal immune system of female reproductive tract (FRT). In addition to host defense functions in the FRT, recent evidences indicate immunomodulatory role of SFTPD in parturition and pre-term labor. Regulation of SFTPD expression by ovarian hormones in the mouse uterus implicates SFTPD of FRT in pregnancy establishment and maintenance. In the current study, we attempted to decipher the functional relevance of SFTPD in FRT by characterizing the fertility parameters of surfactant associated protein D knockout (Sftpd(tm1Jhf)/Sftpd(tm1Jhf)) female mice...
March 2016: Molecular Immunology
Anna Kedzierska-Markowicz, Michał Krekora, Lidia Biesiada, Ewa Głowacka, Grzegorz Krasomski
OBJECTIVES: The aim of the study was to evaluate IL-1β, II-8, IFN-γ cytokine concentrations in cervico-vaginal fluid in patients with threatening preterm delivery. MATERIAL AND METHODS: The study group included 84 patients between 27 and 34 weeks of pregnancy admitted with symptoms of threatened preterm delivery. The cervico-vaginal fluid was taken from each patient qualified for the study and IL-1β, II-8, IFN-γ concentration was analyzed by enzyme-linked immunosorbent assay (ELISA)...
November 2015: Ginekologia Polska
Igor Hudic, Adolf E Schindler, Julia Szekeres-Bartho, Babill Stray-Pedersen
Progestin supplementation appears to be a promising approach to both preventing initiation of pre-term labor and treating it once it is already established. Successful pregnancy depends on maternal tolerance of the fetal "semi-allograft". A protein called progesterone-induced blocking factor (PIBF), by inducing a Th2 dominant cytokine production mediates the immunological effects of progesterone. Over time, various attempts have been made to clarify the question, whether progestogens can contribute positively to either prevention or treatment of pre-term labor and birth...
September 1, 2016: Hormone Molecular Biology and Clinical Investigation
Maria Laura Annunziata, Salvatore Tagliaferri, Francesca Giovanna Esposito, Natascia Giuliano, Flavia Mereghini, Andrea Di Lieto, Marta Campanile
AIM: To analyze computerized cardiotocographic (cCTG) parameters (baseline fetal heart rate, baseline FHR; short term variability, STV; approximate entropy, ApEn; low frequency, LF; movement frequency, MF; high frequency, HF) in physiological pregnancy in order to correlate them with the stages of labor. This could provide more information for understanding the mechanisms of nervous system control of FHR during labor progression. METHODS: A total of 534 pregnant women were monitored on cCTG from the 37th week before the onset of spontaneous labor and during the first and the second stage of labor...
March 2016: Journal of Obstetrics and Gynaecology Research
Bibi Leila Hoseini, Zahra Miri Kalateh Sadati, Mohammad Hassan Rakhshani
INTRODUCTION: The neonatal mortality rate (NMR) is an essential index in the assessment of community health. With the rapid advancement of neonatal care, the causes of death in this group and the overall mortality rate have changed. For these reasons, the aim of this study was to determine the current NMR and its causes in Sabzevar City's Neonatal Intensive Care Unit (NICU). METHODS: This cross-sectional study was conducted in the NICU at Sabzevar Hospital from 2006 through 2013...
November 2015: Electronic Physician
Neda Dj Perunovic, Mia M Rakic, Ljubinka I Nikolic, Sasa M Jankovic, Zoran M Aleksic, Darko V Plecas, Phoebus N Madianos, Sasa S Cakic
BACKGROUND: Periodontitis is considered to be a risk factor for preterm birth. Mechanisms have been proposed for this pathologic relation, but the exact pathologic pattern remains unclear. Therefore, the objective of the present study is to evaluate levels of four major labor triggers, prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, in gingival crevicular fluid (GCF) and serum samples between women with preterm birth (PTB) and full-term birth (FTB) and correlate them with periodontal parameters...
March 2016: Journal of Periodontology
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