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https://www.readbyqxmd.com/read/29166454/the-clinical-genetics-of-phaeochromocytoma-and-paraganglioma
#1
P T Kavinga Gunawardane, Ashley Grossman
Phaeochromocytoma and paraganglioma are rare catecholamine-producing tumours, recognised to have one of the richest hereditary backgrounds of all neoplasms, with germline mutations seen in approximately 30% of patients. They can be a part of genetic syndromes such as MEN 2 or Neurofibromatosis type 1, or can be found as apparently sporadic tumours. Germline mutations are almost always found in syndromic patients. Nonetheless, apparently sporadic phaeochromocytoma too show high germline mutation rates. Early detection of a genetic mutation can lead to early diagnosis of further tumours via surveillance, early treatment and better prognosis...
October 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29165691/estradiol-protects-proopiomelanocortin-neurons-against-insulin-resistance
#2
Jian Qiu, Martha A Bosch, Cecilia Meza, Uyen-Vy Navarro, Casey C Nestor, Edward J Wagner, Oline K Rønnekleiv, Martin J Kelly
Insulin resistance is at the core of the metabolic syndrome, and men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage diminishes sharply when women reach the postmenopausal state. Since 17β-estradiol (E2) augments the excitability of the anorexigenic POMC neurons, we investigated the neuroprotective effects of E2 against insulin resistance in POMC neurons from diet-induced obese (DIO) female and male mice. The efficacy of insulin to activate canonical transient receptor potential 5 (TRPC5) channels and depolarize POMC neurons was significantly reduced in DIO male but not in DIO female mice...
November 20, 2017: Endocrinology
https://www.readbyqxmd.com/read/29164792/validity-and-correlates-of-the-international-physical-activity-questionnaire-in-first-episode-psychosis
#3
Davy Vancampfort, Marc De Hert, Inez Myin-Germeys, Simon Rosenbaum, Brendon Stubbs, Tine Van Damme, Michel Probst
AIM: The International Physical Activity Questionnaire (IPAQ) is a self-report tool commonly used in mental healthcare settings to assess physical activity. However, its validity has not yet been investigated in first-episode psychosis (FEP). The aim of this study was to examine the concurrent validity of the IPAQ compared with an objective real-life measure, the Sensewear Armband (SWA), in assessing moderate and vigorous physical activity (MVPA) in people with FEP. A secondary aim was to explore whether there are differences in correlates of the IPAQ vs SWA scores...
November 22, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29164643/interaction-between-alcohol-consumption-and-metabolic-syndrome-in-predicting-severe-liver-disease-in-the-general-population
#4
Fredrik Åberg, Jaana Helenius-Hietala, Pauli Puukka, Martti Färkkilä, Antti Jula
The metabolic syndrome and alcohol risk use are both associated with high prevalence of hepatic steatosis, but only a minority develop liver failure or liver cancer. Few general population studies have analyzed metabolic predictors of such severe liver complications. We studied which metabolic factors best predict severe liver complications, stratified by alcohol consumption. 6732 individuals without baseline liver disease who participated in the Finnish population-based Health 2000 Study (2000-2001), a nationally representative cohort...
November 22, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29155934/controlled-flow-diversion-in-hybrid-venoarterial-venous-extracorporeal-membrane-oxygenation
#5
Mehmet Cakici, Fatih Gumus, Evren Ozcinar, Cagdas Baran, Onat Bermede, Mustafa Bahadir Inan, Mustafa Serkan Durdu, Mustafa Sirlak, Ahmet Ruchan Akar
OBJECTIVES: Patients on venoarterial or venovenous extracorporeal membrane oxygenation (ECMO) support may require venoarterial-venous (VAV-ECMO) configuration during follow-up. We report 12 cases of VAV-ECMO with significant outflow steal. METHODS: Between October 2014 and November 2016, a total of 97 patients (56.6 ± 12.0 years; 59 men/38 women; body surface area 1.84 ± 0.36 m 2 ) were supported with venoarterial ECMO ( n  = 85) or venovenous ECMO ( n  = 12)...
August 16, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29153942/metabolic-syndrome-and-low-high-density-lipoprotein-cholesterol-are-associated-with-adverse-pathological-features-in-patients-with-prostate-cancer-treated-by-radical-prostatectomy
#6
Souhil Lebdai, Romain Mathieu, Julie Leger, Olivier Haillot, Sébastien Vincendeau, Nathalie Rioux-Leclercq, Georges Fournier, Marie-Aimée Perrouin-Verbe, Laurent Doucet, Abdel Rahmene Azzouzi, Jérome Rigaud, Karine Renaudin, Thomas Charles, Franck Bruyere, Gaelle Fromont
BACKGROUND: Previous studies have suggested a link between metabolic syndrome (MetS) and prostate cancer (PCa). In the present study, we aimed to assess the association between MetS and markers of PCa aggressiveness on radical prostatectomy (RP). METHODS: All patients consecutively treated for PCa by RP in 6 academic institutions between August 2013 and July 2016 were included. MetS was defined as at least 3 of 5 components (obesity, elevated blood pressure, diabetes, low high-density lipoprotein (HDL)-cholesterol, and hypertriglyceridemia)...
November 16, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29153594/the-effectiveness-of-extracorporeal-shockwave-treatment-in-subacromial-impingement-syndrome-and-its-relation-with-acromion-morphology
#7
Esra Circi, Sibel Caglar Okur, Ozge Aksu, Erhan Mumcuoglu, Tolga Tuzuner, Nil Caglar
OBJECTIVE: The aim of this study was to evaluate the effectiveness of the extracorporeal shock wave therapy in the subacromial impingement syndrome and its relationship with the acromion morphology. METHODS: Thirty patients (24 women, 6 men) with subacromial impingement were evaluated. The average age of patients was 53.6 ± 9.8 years (range 39-80). Patients were divided into 3 groups according to the acromion morphology. ESWT 1500 at 0.12 am mL/mm(2) violence was applied once a week for 3 weeks...
November 16, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29151477/nutrient-derived-dietary-patterns-and-their-association-with-metabolic-syndrome-in-a-japanese-population
#8
Tirani Bahari, Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Keisuke Miki, Masashi Ishizu, Kokichi Arisawa
BACKGROUND: Nutrients have been proposed to be related to metabolic syndrome (MetS). The aims of this study were to identify dietary patterns that correlated with several nutrients using reduced rank regression (RRR) and to examine the association between extracted dietary patterns and prevalence of MetS in a Japanese population. METHODS: The study population comprised 1,092 Japanese men and women (35-69 years old) who had participated in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study in Tokushima Prefecture...
November 18, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29151034/efficacy-and-safety-of-adding-ezetimibe-to-statin-therapy-among-women-and-men-insight-from-improve-it-improved-reduction-of-outcomes-vytorin-efficacy-international-trial
#9
Eri Toda Kato, Christopher P Cannon, Michael A Blazing, Erin Bohula, Sema Guneri, Jennifer A White, Sabina A Murphy, Jeong-Gun Park, Eugene Braunwald, Robert P Giugliano
BACKGROUND: IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) showed that adding the nonstatin ezetimibe to statin therapy further reduced cardiovascular events in patients after an acute coronary syndrome. In a prespecified analysis, we explore results stratified by sex. METHODS AND RESULTS: In IMPROVE-IT, patients with acute coronary syndrome and low-density lipoprotein cholesterol of 50 to 125 mg/dL were randomized to placebo/simvastatin 40 mg or ezetimibe/simvastatin 10/40 mg...
November 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29150168/exploring-the-path-between-depression-anxiety-and-10-year-cardiovascular-disease-incidence-among-apparently-healthy-greek-middle-aged-adults-the-attica-study
#10
Natasa Kollia, Demosthenes Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Mary Yannakoulia, Christodoulos Stefanadis, Somnath Chatterji, Josep Maria Haro, Charalabos Papageorgiou, Christos Pitsavos
OBJECTIVES: Although there is substantial evidence that psychological factors play an important role in the onset and course of cardiovascular disease (CVD), less is known about their combined effect and the pathways by which they affect cardiovascular health. The present work aimed to prospectively explore the effects of depression and anxiety on the 10-year CVD incidence, in relation to other lifestyle determinants, as linking factors in the context of the ATTICA study. Study design/Main outcome measures: The ATTICA study is a population-based, health and nutrition prospective cohort study (2002-2012), during which 853 middle-aged participants without a history of CVD [453 men (aged 45±13years) and 400 women (aged 44±18years)], underwent psychological evaluations at enrollment...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29146142/visceral-adiposity-index-as-a-predictor-of-chronic-kidney-disease-in-a-relatively-healthy-population-in-taiwan
#11
Yi-Chuan Chen, Shih-Han Lai, Yi-Wen Tsai, Shy-Shin Chang
OBJECTIVES: Abdominal obesity is an independent risk factor for cardiovascular disease and chronic kidney disease (CKD). Visceral adiposity index (VAI), a simple formula representing visceral adipose dysfunction, has already been proven to have a strong correlation with various cardiometabolic disorders. Limited studies are available regarding the relationship between VAI and renal function decline. Therefore, the purpose of this study was to evaluate the relationship between VAI and renal function and to estimate the risk of chronic kidney disease in a relatively healthy adult population in Taiwan...
November 14, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29144029/neck-circumference-a-valuable-anthropometric-measurement-to-detect-metabolic-syndrome-among-different-age-groups-in-china
#12
Ting Cui, Ban-Huao Yan, Zhan Liu, Hui Yang, Michael Gyan, Yu-Xia Ma
OBJECTIVES: The aim of this study was to investigate the correlation between neck circumference (NC) and metabolic syndrome (MS) in Chinese residents and to explore the cut-off points of NC for MS in different age groups. METHODS: In all, 4227 Chinese adults (18-90 years) were enrolled in the study and divided into three subgroups (young, middle-aged and elderly) according to their ages. The compared data for the subjects included anthropometric indicators and biochemical detection indices...
November 16, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29141844/architectural-t-wave-analysis-and-identification-of-on-therapy-breakthrough-arrhythmic-risk-in-type-1-and-type-2-long-qt-syndrome
#13
Alan Sugrue, Ram K Rohatgi, Peter A Noseworthy, Vaclav Kremen, J Martijn Bos, Bo Qiang, Yehu Sapir, Zachi I Attia, Christopher G Scott, Peter Brady, Samuel J Asirvatham, Paul A Friedman, Michael J Ackerman
BACKGROUND: Although the hallmark of long-QT syndrome (LQTS) is abnormal cardiac repolarization, there are varying degrees of phenotypic expression and arrhythmic risk. Our aim was to evaluate the performance of a morphological T-wave analysis program in defining breakthrough LQTS arrhythmic risk beyond the QTc value. METHODS AND RESULTS: We analyzed 407 genetically confirmed patients with LQT1 (n=246; 43% men) and LQT2 (n=161; 41% men) over the mean follow-up period of 6...
November 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29139249/-clinical-features-analysis-of-qingkailing-injection-for-adolescent-patients-based-on-real-world-his
#14
Li-Zhen Chen, Yan-Ming Xie, Lian-Xin Wang, Yin Zhang, Qun Wang, Ping-Ping Jia, Bo Feng
To explore the clinical application features of Qingkailing injection for adolescent patients. This study was based on the information from the hospitalized patients in 1998-2011 in HIS (hospital information system) of 16 tertiary hospitals in China. 615 adolescent patients with Qingkailing injection were used to investigate the clinical characteristics of Qingkailing injection. Apriori algorithm was adopted to establish the model, and Clementine 12.0 was used for correlation analysis. The results showed that male patients (355 cases) were more than female patients (243 cases); the age of the most patients was under 14 years old, with an average age of 9...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29136166/diabetes-induced-hyperglycemia-impairs-male-reproductive-function-a-systematic-review
#15
Constanze C Maresch, Dina C Stute, Marco G Alves, Pedro F Oliveira, David M de Kretser, Thomas Linn
BACKGROUND: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing...
November 10, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29132116/the-outcome-of-laparoscopic-subtotal-cholecystectomy-in-difficult-cases-a-case-series
#16
Caroline Supit, Tommy Supit, Yarman Mazni, Ibrahim Basir
INTRODUCTION: Laparoscopic subtotal cholecystectomy (LSC) is a widely used technique for managing cholelithiasis with severe cholecystitis. The increasing popularity its utilization is due to the good safety profile and acceptable results. This case series evaluates the short- and long-term results of Indonesian patients who underwent LSC with an objective to determine whether the procedure can be a standard approach for difficult cholecystectomy in our institution. PRESENTATION OF CASE: Thirty-four Indonesian patients (26 men, 8 women) with the mean age of 54...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29131401/nonalcoholic-fatty-liver-disease-and-the-development-of-reflux-esophagitis-a-cohort-study
#17
Yang Won Min, Youngha Kim, Geum-Youn Gwak, Seonhye Gu, Danbee Kang, Soo Jin Cho, Eliseo Guallar, Juhee Cho, Dong Hyun Sinn
BACKGROUNDS/AIMS: Nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of the metabolic syndrome, is associated with gastroesophageal reflux disease in cross-sectional studies, but a prospective association has not been evaluated. The current study aimed to determine whether NAFLD increases the risk of incident reflux esophagitis in a large cohort study. METHODS: We conducted a cohort study of 34,063 men and women without reflux esophagitis or other upper gastrointestinal disease at baseline who underwent health check-up examinations between January 2003 and December 2013...
November 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29130065/metabolic-syndrome-in-apparently-healthy-ghanaian-adults-a-systematic-review-and-meta-analysis
#18
REVIEW
Richard Ofori-Asenso, Akosua Adom Agyeman, Amos Laar
Background: Metabolic syndrome (MetS) is a major public health problem in Sub-Saharan Africa. We systematically reviewed the literature towards estimating the prevalence of MetS among apparently "healthy" Ghanaian adults. Methods: We searched PubMed, Web of Science, Scopus, Africa Journals Online, African Index Medicus, and Google scholar as well as the websites of the Ministry of Health and Ghana Health service through September 2016. Only studies conducted among apparently "healthy" (no established disease, e...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29129471/higher-intake-of-fish-and-fat-is-associated-with-lower-plasma-s-adenosylhomocysteine-a-cross-sectional-study
#19
Mads V Lind, Lotte Lauritzen, Oluf Pedersen, Henrik Vestergaard, Ken D Stark, Torben Hansen, Alastair B Ross, Mette Kristensen
Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome...
October 2, 2017: Nutrition Research
https://www.readbyqxmd.com/read/29128315/parathyroid-hormone-calcidiol-calcitriol-and-adverse-events-in-the-acute-coronary-syndrome
#20
P Ramos Ruiz, L Jaulent Huertas, M Castañeda Sancirilo, J J Martínez Díaz, G Clavel Ruipérez, L García de Guadiana Romualdo, S Wasniewski, M Merelo Nicolás, I García Escribano, F Soria Arcos, J A Castillo Moreno, L Consuegra Sánchez
OBJECTIVE: To know the clinical profile as well as the prognostic significance of elevated levels of parathyroid hormone (PTH) in patients admitted for acute coronary syndrome (ACS). DESIGN AND SETTING: Observational and prospective study of patients admitted for ACS in a single Spanish center during a period of six months. INTERVENTION AND VARIABLES OF INTEREST: The circulating concentrations of PTH, calcidiol, calcitriol, NT-proBNP, C-reactive protein, cystatinC and fibrinogen were determined within the first 48h at admission...
November 8, 2017: Medicina Intensiva
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