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https://www.readbyqxmd.com/read/29773953/mir-34a-mediated-regulation-of-xist-in-female-cells-under-inflammation
#1
Botros B Shenoda, Yuzhen Tian, Guillermo M Alexander, Enrique Aradillas-Lopez, Robert J Schwartzman, Seena K Ajit
Background: Evidence is overwhelming for sex differences in pain, with women representing the majority of the chronic pain patient population. There is a need to explore novel avenues to elucidate this sex bias in the development of chronic inflammatory pain conditions. Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder, and the incidence of CRPS is greater in women than in men by ~4:1. Since neurogenic inflammation is a key feature of CRPS, dysregulation of inflammatory responses can be a factor in predisposing women to chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29772682/the-association-of-dietary-fiber-intake-with-cardiometabolic-risk-in-four-countries-across-the-epidemiologic-transition
#2
Louise Lie, Laquita Brown, Terrence E Forrester, Jacob Plange-Rhule, Pascal Bovet, Estelle V Lambert, Brian T Layden, Amy Luke, Lara R Dugas
The greatest burden of cardiovascular disease is now carried by developing countries with cardiometabolic conditions such as metabolic syndrome, obesity and inflammation believed to be the driving force behind this epidemic. Dietary fiber is known to have protective effects against obesity, type 2 diabetes, cardiovascular disease and the metabolic syndrome. Considering the emerging prevalence of these cardiometabolic disease states across the epidemiologic transition, the objective of this study is to explore these associations of dietary fiber with cardiometabolic risk factors in four countries across the epidemiologic transition...
May 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29772387/validation-of-the-seattle-angina-questionnaire-in-women-with-ischemic-heart-disease
#3
Krishna K Patel, Suzanne V Arnold, Paul S Chan, Yuanyuan Tang, Philip G Jones, Jianping Guo, Donna M Buchanan, Mohammed Qintar, Carole Decker, David A Morrow, John A Spertus
BACKGROUND: Although the Seattle Angina Questionnaire (SAQ) has been widely used to assess disease-specific health status in patients with ischemic heart disease, it was originally developed in a predominantly male population and its validity in women has been questioned. METHODS: Using data from 8892 men and 4013 women across 2 multicenter trials and 5 registries, we assessed the construct validity, test-retest reliability, responsiveness to clinical change, and predictive validity of the SAQ Summary Score (SS) and its 5 subdomains (Physical Limitation (PL), Anginal Stability (AS), Angina Frequency (AF), Treatment Satisfaction (TS), and Quality of Life (QoL)) separately in men and women...
April 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29770485/elongated-transverse-aortic-arch-%C3%A4-n-subjects-without-turner-syndrome-a-preliminary-computed-tomography-study
#4
B Ece, H Yiğit, E Ergün, P N Koşar
INTRODUCTION: The purpose of the present study was to investigate the presence of an elongated transverse aortic arch (ETA), which has been reported to be specific for Turner syndrome, in a population without Turner syndrome. MATERIALS AND METHODS: A set of 1012 patients (713 men, 299 women) under 40 years old, who underwent thoracic CT examination in our radiology department between July 2016 and December 2016, were included in the study. CT scans were performed by 16-slice scanners...
May 17, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29768035/microgravity-induced-ocular-changes-are-related-to-body-weight
#5
Jay C Buckey, Scott D Phillips, Allison P Anderson, Ariane B Chepko, Veronique Archambault-Leger, Jiang Gui, Abigail M Fellows
On Earth, tissue weight generates compressive forces that press on body structures and act on the walls of vessels throughout the body. In microgravity tissues no longer have any weight and tissue compressive forces are lost, suggesting individuals who weigh more may show greater effects from microgravity exposure. One unique effect of long-duration microgravity exposure is the spaceflight-associated neuro-ocular syndrome (SANS) which can present with globe flattening, choroidal folds, optic disc edema, and a hyperopic visual shift...
May 16, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29765443/management-of-cardiac-hemochromatosis
#6
Wilbert S Aronow
Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration. Cardiac hemochromatosis is characterized by a dilated cardiomyopathy with dilated ventricles, reduced ejection fraction, and reduced fractional shortening. Deposition of iron may occur in the entire cardiac conduction system, especially the atrioventricular node. Cardiac hemochromatosis should be considered in any patient with unexplained heart failure...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29764718/metabolic-syndrome-associates-with-left-atrial-dysfunction
#7
K Nyman, M Granér, M O Pentikäinen, J Lundbom, A Hakkarainen, R Sirén, M S Nieminen, M-R Taskinen, N Lundbom, K Lauerma
BACKGROUND AND AIMS: Obesity and metabolic syndrome (MetS) are risk factors of atrial fibrillation (AF), but limited data exist on their effect on left atrial (LA) function. The aim of the study was to evaluate the effects of cardiac, hepatic and intra-abdominal ectopic fat depots and cardiometabolic risk factors on LA function in non-diabetic male subjects. METHODS AND RESULTS: Myocardial and hepatic triglyceride contents were measured with 1.5T 1 H-magnetic resonance spectroscopy and LA and left ventricular function, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial and pericardial fat by magnetic resonance imaging (MRI) in 33 men with MetS and 40 men without MetS...
February 21, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29759541/the-phenotypic-spectrum-of-a-mutation-hotspot-responsible-for-the-short-qt-syndrome
#8
Dan Hu, Yang Li, Jiancheng Zhang, Ryan Pfeiffer, Michael H Gollob, Jeff Healey, Daniel Toshio Harrell, Naomasa Makita, Haruhiko Abe, Yaxun Sun, Jihong Guo, Li Zhang, Ganxin Yan, Douglas Mah, Edward P Walsh, Harris B Leopold, Carla Giustetto, Fiorenzo Gaita, Agnieszka Zienciuk-Krajka, Andrea Mazzanti, Silvia G Priori, Charles Antzelevitch, Hector Barajas-Martinez
OBJECTIVES: This study sought to evaluate the phenotypic and functional expression of an apparent hotspot mutation associated with short QT syndrome (SQTS). BACKGROUND: SQTS is a rare channelopathy associated with a high risk of life-threatening arrhythmias and sudden cardiac death (SCD). METHODS: Probands diagnosed with SQTS and their family members were evaluated clinically and genetically. KCNH2 wild-type (WT) and mutant genes were transiently expressed in HEK293 cells, and currents were recorded using whole-cell patch clamp and action potential (AP) clamp techniques...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759108/a-western-dietary-pattern-is-prospectively-associated-with-cardio-metabolic-traits-and-incidence-of-the-metabolic-syndrome
#9
Isabel Drake, Emily Sonestedt, Ulrika Ericson, Peter Wallström, Marju Orho-Melander
The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL- and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin)...
May 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29757454/non-pharmacological-interventions-for-treating-chronic-prostatitis-chronic-pelvic-pain-syndrome
#10
REVIEW
Juan Va Franco, Tarek Turk, Jae Hung Jung, Yu-Tian Xiao, Stanislav Iakhno, Virginia Garrote, Valeria Vietto
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common disorder in which the two main clinical features are pelvic pain and lower urinary tract symptoms. There are currently many approaches for its management, using both pharmacological and non-pharmacological interventions. The National Institute of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) score is a validated measure commonly used to measure CP/CPPS symptoms. OBJECTIVES: To assess the effects of non-pharmacological therapies for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS)...
May 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29756419/growth-hormone-and-aging-updated-review
#11
REVIEW
Andrzej Bartke
Role of growth hormone (GH) in mammalian aging is actively explored in clinical, epidemiological, and experimental studies. The age-related decline in GH levels is variously interpreted as a symptom of neuroendocrine aging, as one of causes of altered body composition and other unwelcome symptoms of aging, or as a mechanism of natural protection from cancer and other chronic diseases. Absence of GH signals due to mutations affecting anterior pituitary development, GH secretion, or GH receptors produces an impressive extension of longevity in laboratory mice...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29750266/hyperuricemia-is-associated-with-a-higher-prevalence-of-metabolic-syndrome-in-military-individuals
#12
Cheng-Wei Liu, Wei-Cheng Chang, Chiao-Chin Lee, Ko-Hung Chen, Yen-Wen Wu, Juey-Jen Hwang
Introduction: Hyperuricemia (HUA) is associated with metabolic syndrome (MetS) in the general population. Military individuals who perform high-intensity physical training might have lower rates of MetS. The present study aimed to investigate whether HUA might be associated with the prevalence of MetS in military individuals. Material and Methods: We retrospectively collected data from the annual military exam and randomly selected a single unit to represent the overall study population...
May 10, 2018: Military Medicine
https://www.readbyqxmd.com/read/29746789/effect-of-carbohydrate-restriction-induced-weight-loss-on-aortic-pulse-wave-velocity-in-overweight-men-and-women
#13
Majid M Syed-Abdul, Qiong Hu, Miriam Jacome-Sosa, Jaume Padilla, Camila Manrique-Acevedo, Colette Heimowitz, Elizabeth J Parks
Increased aortic stiffness, measured by carotid-to-femoral pulse wave velocity (PWV), is an independent predictor of cardiovascular disease (CVD) and past data have shown that low-fat and low-energy diets, fed for 8-24 wks lower PWV. The purpose of this study was to determine whether a reduction in PWV would be achieved by dietary carbohydrate (CHO) restriction, shown to bring about weight loss over a shorter timeframe. Men [n=10, age: 41.8 ± 3.2 y, BMI: 34.2 ± 1.0 kg/m2 (mean±SE)] and women (n=10, age: 38...
May 10, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29743419/metabolic-syndrome-and-the-risk-of-new-onset-atrial-fibrillation-in-middle-aged-east-asian-men
#14
Yong-Giun Kim, Kee-Joon Choi, Seungbong Han, Ki Won Hwang, Chang Hee Kwon, Gyung-Min Park, Ki-Bum Won, Soe Hee Ann, Jun Kim, Shin-Jae Kim, Sang-Gon Lee, Gi-Byoung Nam, You-Ho Kim
BACKGROUND: Although the prevalence of both atrial fibrillation (AF) and metabolic syndrome (MetS) has been increasing in East Asia, the association between them is uncertain.Methods and Results:A total of 24,741 middle-aged Korean men without baseline AF were enrolled in a health screening program from January 2003 to December 2008. Among them, 21,981 subjects were evaluated to determine the risk of AF based on baseline MetS status through December 2016. At every visit, the subjects were evaluated for AF using ECG...
May 10, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29743317/longitudinal-associations-of-high-density-lipoprotein-cholesterol-or-low-density-lipoprotein-cholesterol-with-metabolic-syndrome-in-the-chinese-population-a-prospective-cohort-study
#15
Xiao-Rong Wang, Gui-Rong Song, Meng Li, Hong-Ge Sun, Yong-Jun Fan, Ying Liu, Qi-Gui Liu
OBJECTIVE: Currently, most studies only reveal the relationship between baseline high-density lipoprotein cholesterol (HDL-c) or low-density lipoprotein cholesterol (LDL-c) levels and metabolic syndrome (MetS). The relationship between dynamic changes in HDL-c or LDL-c and MetS remains unclear. We aimed to gain a deeper understanding of the relationship between the dynamic changes in HDL-c or LDL-c and MetS. DESIGN: A prospective study. SETTING: The Medical Centre of the Second Hospital affiliated with Dalian Medical University from 2010 to 2016...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29742999/mycoplasma-genitalium-infections-in-cuba-surveillance-of-urogenital-syndromes-2014-2015
#16
Brian A Mondeja, Nadia M Rodríguez, Orestes Blanco, Carmen Fernández, Jørgen S Jensen
Mycoplasma genitalium is an emerging sexually transmitted pathogen implicated in urethritis in men and several inflammatory reproductive tract syndromes in women. The prevalence of M. genitalium infections in Cuban patients with urogenital syndromes is unknown. The aim of this study was to analyse the prevalence of M. genitalium infection in sexually-active Cuban men and women with urogenital syndromes as a part of aetiological surveillance of urogenital syndromes in Cuba. Samples from men and women with urogenital syndromes submitted to the Mycoplasma Reference Laboratory for mycoplasma diagnosis from 1 January 2014 to 1 June 2015 were analysed by polymerase chain reaction (PCR) for detection of M...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29742114/the-magnitude-of-obesity-and-metabolic-syndrome-among-diabetic-chronic-kidney-disease-population-a-nationwide-study
#17
Piyawan Kittiskulnam, Nintita Sripaiboonkij Thokanit, Pisut Katavetin, Paweena Susanthitaphong, Nattachai Srisawat, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong
BACKGROUND: Although the prevalence of obesity and metabolic syndrome (MetS) among dialysis patients has been exceeding than general population, little is known regarding obesity and MetS in non-dialysis chronic kidney disease (CKD). We aimed to find the magnitude of obesity and MetS and their associations with impaired renal function among type 2 diabetes mellitus (T2DM) patients. METHODS: A national survey of T2DM patients was collected in the Thai National Health Security Office database during 2014-5...
2018: PloS One
https://www.readbyqxmd.com/read/29740550/effects-of-socioeconomic-status-health-behavior-and-physical-activity-on-the-prevalence-of-metabolic-syndrome
#18
Yong Hwan Kim, Hongkyu Kim, Haemi Jee
Routine medical checkups have been provided by both the government-led and private hospitals for the purposes of prevention and early detection of diseases. Various studies were conducted with clinical results obtained from both government and private hospital based results. However, results from two types of health checkups have not been conducted. The results should be compared for the prevalence of metabolic disease in the aspects of socioeconomic status and health care behaviors to observe the pros and cons of two types of health checkups...
April 2018: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29739793/association-between-adiposity-and-lean-mass-with-long-term-cardiovascular-events-in-patients-with-coronary-artery-disease-no-paradox
#19
Jose R Medina-Inojosa, Virend K Somers, Randal J Thomas, Nathalie Jean, Sarah M Jenkins, Miguel Angel Gomez-Ibarra, Marta Supervia, Francisco Lopez-Jimenez
BACKGROUND: Prognosis based on body fat percentage (BF%) in patients with coronary artery disease has not been extensively studied. We tested the hypothesis that patients with coronary artery disease and increased BF% have a higher risk for major adverse cardiovascular events (MACEs) and that fat-free mass is associated with better prognosis. METHODS AND RESULTS: We included 717 patients referred to cardiac rehabilitation after coronary artery disease events or procedures who underwent air displacement plethysmography to assess BF%; 75% were men, with a mean age 61...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29734698/disparate-habitual-physical-activity-and-dietary-intake-profiles-of-elderly-men-with-low-and-elevated-systemic-inflammation
#20
Dimitrios Draganidis, Athanasios Z Jamurtas, Theodoros Stampoulis, Vasiliki C Laschou, Chariklia K Deli, Kalliopi Georgakouli, Konstantinos Papanikolaou, Athanasios Chatzinikolaou, Maria Michalopoulou, Constantinos Papadopoulos, Panagiotis Tsimeas, Niki Chondrogianni, Yiannis Koutedakis, Leonidas G Karagounis, Ioannis G Fatouros
The development of chronic, low-grade systemic inflammation in the elderly (inflammaging) has been associated with increased incidence of chronic diseases, geriatric syndromes, and functional impairments. The aim of this study was to examine differences in habitual physical activity (PA), dietary intake patterns, and musculoskeletal performance among community-dwelling elderly men with low and elevated systemic inflammation. Nonsarcopenic older men free of chronic diseases were grouped as ‘low’ (LSI: n = 17; 68...
May 4, 2018: Nutrients
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