Pedro A M Mediano, Fernando E Rosas, Christopher Timmermann, Leor Roseman, David J Nutt, Amanda Feilding, Mendel Kaelen, Morten L Kringelbach, Adam B Barrett, Anil K Seth, Suresh Muthukumaraswamy, Daniel Bor, Robin L Carhart-Harris
Recent findings have shown that psychedelics reliably enhance brain entropy (understood as neural signal diversity), and this effect has been associated with both acute and long-term psychological outcomes, such as personality changes. These findings are particularly intriguing, given that a decrease of brain entropy is a robust indicator of loss of consciousness (e.g., from wakefulness to sleep). However, little is known about how context impacts the entropy-enhancing effect of psychedelics, which carries important implications for how it can be exploited in, for example, psychedelic psychotherapy...
January 12, 2024: ACS Chemical Neuroscience