Zhong-Da Li, Fangfang Liu, Yanqiao Zeng, Yingnan Liu, Wenhe Luo, Feng Yuan, Su Li, Qi Li, Jiaxin Chen, Mayumi Fujita, Guofang Zhang, Yang Li
Epigallocatechin-3-gallate (EGCG) is an important tea polyphenol with anti-tumor potential. Our previous studies revealed that EGCG was a promising immune checkpoint inhibitor (ICI) as it could downregulate expression of programmed cell death 1 ligand 1 (PD-L1) in tumor cells, thereby resulting tumor killing effect. In particular, EGCG can effectively avoid the inflammatory storm caused by anti-tumor therapy, which is a healthy green capacity absent from many ICIs. However, the relationship between EGCG and programmed cell death 1 (PD-1) of T cells remains unclear...
April 20, 2024: International Immunopharmacology