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https://www.readbyqxmd.com/read/27936296/antiangiogenic-and-toxic-effects-of-genistein-usnic-acid-and-their-copper-complexes-in-zebrafish-embryos-at-different-developmental-stages
#1
Heidrun Draut, Tobias Rehm, Gerrit Begemann, Rainer Schobert
Angiogenesis plays a major role in the normal embryonic development and in diseases such as cancer. Drugs that control angiogenesis are an alternative way to tackle this disease. The polyphenols usnic acid 3, genistein 5, and daidzein 6 were tested for antiangiogenic and unwanted effects in zebrafish embryos whose blood vessel system resembles that of mammals. The established tyrosine kinase inhibitors axitinib 1 and tyrphostin AG490 2 were included for comparison. All compounds except 6 caused distinct antiangiogenic effects such as a concentration-dependent reduction of intersegmental vessels, dorsal longitudinal anastomotic vessels, subintestinal veins and secondary sprouts...
December 9, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27936114/long-circulating-curcumin-loaded-liposome-formulations-with-high-incorporation-efficiency-stability-and-anticancer-activity-towards-pancreatic-adenocarcinoma-cell-lines-in-vitro
#2
Mohamed Mahmud, Adriana Piwoni, Nina Filiczak, Martyna Janicka, Jerzy Gubernator
The incorporation of hydrophobic drugs into liposomes improve their bioavailability and leads to increased stability and anticancer activity, along with decreased drug toxicity. Curcumin (Cur) is a natural polyphenol compound with a potent anticancer activity in pancreatic adenocarcinoma (PA). In the present study, different types of Cur-loaded liposomal formulations were prepared and characterized in terms of size, shape, zeta potential, optimal drug-to-lipid ratio and stability at 4°C, 37°C; and in human plasma in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/27936080/effects-of-pyrogallol-on-growth-and-cytotoxicity-of-wild-type-and-katg-mutant-strains-of-vibrio-vulnificus
#3
Ju Young Lim, Choon-Mee Kim, Joon Haeng Rhee, Young Ran Kim
Vibrio vulnificus is a causative agent of fatal septicemia and necrotic wound infection and the pathogen infection became an important public health problem in many counties. Vibrio vulnificus causes RtxA1 toxin-induced acute cell death. We tried to identify natural products that inhibit the acute cytotoxicity of V. vulnificus using a lactate hydrogenase assay. A polyphenol pyrogallol protected HeLa cells from V. vulnificus-induced cytotoxicity. Pyrogallol also decreased the growth of V. vulnificus; this inhibitory effect was more significant during log phase than stationary phase...
2016: PloS One
https://www.readbyqxmd.com/read/27936037/the-antioxidative-fraction-of-white-mulberry-induces-apoptosis-through-regulation-of-p53-and-nf%C3%AE%C2%BAb-in-eac-cells
#4
Ahm Khurshid Alam, Asm Sakhawat Hossain, Muhammad Ali Khan, Syed Rashel Kabir, Md Abu Reza, Md Mahbubur Rahman, Mohammad Saiful Islam, Md Aziz Abdur Rahman, Mamunur Rashid, Md Golam Sadik
In this study, the antioxidative fraction of white mulberry (Morus alba) was found to have an apotogenic effect on Ehrlich's ascites carcinoma cell-induced mice (EAC mice) that correlate with upregulated p53 and downregulated NFκB signaling. The antioxidant activities and polyphenolic contents of various mulberry fractions were evaluated by spectrophotometry and the ethyl acetate fraction (EAF) was selected for further analysis. Strikingly, the EAF caused 70.20% tumor growth inhibition with S-phase cell cycle arrest, normalized blood parameters including red/white blood cell counts and suppressed the tumor weight of EAC mice compared with untreated controls...
2016: PloS One
https://www.readbyqxmd.com/read/27935974/epigallocatechin-3-gallate-upregulates-mir-221-to-inhibit-osteopontin-dependent-hepatic-fibrosis
#5
M L Arffa, M A Zapf, A N Kothari, V Chang, G N Gupta, X Ding, M M Al-Gayyar, W Syn, N M Elsherbiny, P C Kuo, Z Mi
Osteopontin (OPN) promotes hepatic fibrosis, and developing therapies targeting OPN expression in settings of hepatic injury holds promise. The polyphenol epigallocatechin-3-gallate (EGCG), found in high concentrations in green tea, downregulates OPN expression through OPN mRNA degradation, but the mechanism is unknown. Previous work has shown that microRNAs can decrease OPN mRNA levels, and other studies have shown that EGCG modulates the expression of multiple microRNAs. In our study, we first demonstrated that OPN induces hepatic stellate cells to transform into an activated state...
2016: PloS One
https://www.readbyqxmd.com/read/27935764/morphofunctional-renal-alterations-in-progeny-of-mice-fed-rhodiola-kirilowii-extracts-or-epigallocatechin-during-pregnancy-and-lactation
#6
Sławomir Lewicki, Ewa Skopińska-Różewska, Barbara Joanna Bałan, Bolesław Kalicki, Janusz Patera, Jacek Wilczak, Aleksander Wasiutyński, Robert Zdanowski
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0...
December 9, 2016: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27935258/polyphenols-from-lonicera-caerulea-l-berry-attenuate-experimental-nonalcoholic-steatohepatitis-by-inhibiting-proinflammatory-cytokines-productions-and-lipid-peroxidation
#7
Shusong Wu, Satoshi Yano, Ayami Hisanaga, Xi He, Jianhua He, Kozue Sakao, De-Xing Hou
SCOPE: Nonalcoholic steatohepatitis (NASH) is a common disease that closely associated with inflammation and oxidative stress, and Lonicera caerulea L. polyphenols (LCP) are reported to possess both antioxidant and anti-inflammatory properties. This study aimed to study the protective effects and mechanisms of LCP on NASH in a high fat diet (HFD) plus carbon tetrachloride (CCL4 )-induced mouse model. METHODS AND RESULTS: Mice were fed with HFD containing LCP (0...
December 9, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27934293/fate-of-anthocyanins-through-cocoa-fermentation-emergence-of-new-polyphenolic-dimers
#8
Cédric De Taeye, Victor Jos Eyamo Evina, Gilles Caullet, Nicolas Niemenak, Sonia Collin
Fresh, ripe cocoa beans from Cameroon (German cocoa/Amelonado group and ICS 40/Trinitario group) were subjected to fermentation-like incubations in acetic acid, lactic acid, or both and to natural fermentation. Two naturally fermented samples from Cuba (UF 654/Trinitario group and C 411/Criollo group) were also investigated. Both cyanidin-3-galactoside and cyanidin-3-arabinoside (found as major anthocyanins in colored beans only) were drastically degraded through fermentation, especially in small beans and in the presence of acetic acid...
November 23, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933987/influence-of-geographical-location-of-orchards-on-green-kiwifruit-bioactive-components
#9
Ivana Giangrieco, Simona Proietti, Stefano Moscatello, Lisa Tuppo, Alberto Battistelli, Francesco La Cara, Maurizio Tamburrini, Franco Famiani, Maria Antonietta Ciardiello
Italy is one of the world's major kiwifruit producers and exporters with orchards located in different areas from the north to the south of the peninsula. This study sought to investigate for the first time the possible influence of the geographical location of kiwifruit orchards on some fruit components, selected because of their involvement in beneficial or negative effects on human health. The fruits harvested in 16 Italian areas were analyzed, and the results obtained show that the observed variations of the relative amounts of total proteins, kiwellin, the major allergen actinidin, ascorbate, polyphenols, and superoxide dismutase (SOD)-like activity seem not to be related to the geographical location of the orchards...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933871/food-polyphenol-apigenin-inhibits-the-cytochrome-p450-monoxygenase-branch-of-the-arachidonic-acid-cascade
#10
Maryvonne Steuck, Stefan Hellhake, Nils Helge Schebb
The product of cytochrome P450 monooxygenase (P450) ω-hydroxylation of arachidonic acid (AA), 20- hydroxyeicosatetraenoic acid (HETE), is a potent vasoconstrictor. Utilizing microsomes as well as individual CYP4 isoforms we demonstrate here that flavonoids can block 20-HETE formation. Apigenin inhibits CYP4F2 with an IC50 value of 4.6 μM and 20-HETE formation in human liver and kidney microsomes at 2.4-9.8 μM. Interestingly, the structurally similar naringenin shows no relevant effect on the formation of 20-HETE...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933848/polyphenol-coating-as-an-interlayer-for-thin-film-composite-membranes-with-enhanced-nanofiltration-performance
#11
Xi Zhang, Yan Lv, Hao-Cheng Yang, Yong Du, Zhi-Kang Xu
Thin-film composite (TFC) nanofiltration membranes are prepared via interfacial polymerization with a polyphenol coating as an interlayer for the thin and smooth polyamide selective layer. The polyphenol interlayer is simply fabricated by the codeposition of tannic acid and diethylenetriamine without changing the surface morphology of the polysulfone ultrafiltration substrate. An interfacial polymerization is conducted from piperazidine and trimesoyl chloride on the polyphenol interlayer to construct the polyamide selective layer...
November 30, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27931714/host-plant-growth-promotion-and-cadmium-detoxification-in-solanum-nigrum-mediated-by-endophytic-fungi
#12
Abdur Rahim Khan, Ihsan Ullah, Muhammad Waqas, Gun-Seok Park, Abdul Latif Khan, Sung-Jun Hong, Rehman Ullah, Byung Kwon Jung, Chang Eon Park, Shafiq Ur-Rehman, In-Jung Lee, Jae-Ho Shin
Current investigation conducted to evaluate the associated fungal endophyte interactions of a Cd hyper-accumulator Solanum nigrum Korean ecotype under varying concentrations of Cd. Two indole-3-acetic acid (IAA) producing fungal strains, RSF-4L and RSF-6L, isolated from the leaves of S. nigrum, were initially screened for Cd tolerance and accumulation potential. In terms of dry biomass production, the strain RSF-6L showed higher tolerance and accumulation capacity for Cd toxicity in comparison to RSF-4L. Therefore, RSF-6L was applied in vivo to S...
February 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27931126/%C3%AE-tocopherol-%C3%AE-carotene-lutein-squalene-and-secoiridoids-in-seven-monocultivar-italian-extra-virgin-olive-oils
#13
Roberto Ambra, Fausta Natella, Sabrina Lucchetti, Valentina Forte, Gianni Pastore
Fatty acids and bioactive lipophilic and hydrophilic compounds (tocopherols, β-carotene, lutein, squalene, total polyphenols and secoiridoids) in monocultivar Italian extra-virgin olive oil (EVOO) samples produced from the Leccino cultivar and six other yet uncharacterised cultivars (Rustica, Carpinetana, Dritta, Gentile di Chieti and Intosso) were analysed, also taking into account the effect of the type of decanter used for the oil extraction. Significant differences among cultivars were found for α-tocopherol and squalene, but not for carotenoids...
December 8, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27931115/secretory-structures-and-essential-oil-composition-in-stachys-officinalis-l-trevisan-subsp-officinalis-lamiaceae-from-italy
#14
Claudia Giuliani, Roberto Maria Pellegrino, Roberta Selvaggi, Corrado Tani, Bruno Tirillini, Laura Maleci Bini
The secretory structures and the volatile fraction of Stachys officinalis (L.) Trevisan subsp. officinalis (Lamiaceae) from Italy were studied for the first time. Peltate and small capitate trichomes were observed on the whole plant (leaves and inflorescences). In the peltate trichomes, an unusual polyphenols content was evidenced by the histochemical methods. The volatile fraction was obtained by a solvent extract from the distillation water of leaves and inflorescences and analysed by GC-MS. Forty-four constituents for leaves, representing 94...
December 8, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27930973/phytosomal-curcumin-a-review-of-pharmacokinetic-experimental-and-clinical-studies
#15
REVIEW
Hamed Mirzaei, Abolfazl Shakeri, Bahman Rashidi, Amin Jalili, Zarrin Banikazemi, Amirhossein Sahebkar
Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability...
December 5, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27929185/melatonin-and-hydroxytyrosol-protect-against-oxidative-stress-related-to-the-central-nervous-system-after-the-ingestion-of-three-types-of-wine-by-healthy-volunteers
#16
Javier Marhuenda, Sonia Medina, Pedro Martínez-Hernández, Simón Arina, Pilar Zafrilla, Juana Mulero, Camille Oger, Jean-Marie Galano, Thierry Durand, Federico Ferreres, Angel Gil-Izquierdo
Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related to oxidative damage in the central nervous system. Besides polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benefits of red wine (excluding colon derivatives). In order to elucidate whether these compounds are responsible for the protective antioxidant effects of red wine, a double-blind, crossover, placebo-controlled in vivo study - involving the intake of red wines and their native musts by healthy volunteers - was performed...
December 8, 2016: Food & Function
https://www.readbyqxmd.com/read/27928704/antioxidant-effects-of-curcuminoids-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#17
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Maryam Saberi Karimian, Muhammed Majeed, Amirhossein Sahebkar
BACKGROUND: Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals. METHODS: In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks...
December 7, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27928119/hypolipidemic-effect-of-the-autoclaved-extract-prepared-from-pea-pisum-sativum-l-pods-in-vivo-and-in-vitro
#18
Kae Inagaki, Yuuki Nishimura, Emiko Iwata, Sachinobu Manabe, Masahiro Goto, Yoshio Ogura, Hisako Hotta
By autoclaving, we obtained a polyphenol and dietary fiber from pea (Pisum sativum L.) pods in parallel without acid or alkali treatment or organic solvent extraction. Rats fed a high-sucrose (HS) diet containing 3% autoclaved extract (AE) for 4 wk exhibited significantly lower serum triglyceride and total cholesterol levels than rats fed a HS diet. AE and soluble dietary fiber (SDF) from AE exhibited pancreatic lipase inhibitory activity at 13.3 mg/mL in vitro. AE and insoluble dietary fiber (IDF) from AE adsorbed cholesterol...
2016: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/27927074/protective-activity-of-hertia-cheirifolia-extracts-against-dna-damage-lipid-peroxidation-and-protein-oxidation
#19
Seoussen Kada, Hamama Bouriche, Abderrahmane Senator, Ibrahim Demirtaş, Tevfik Özen, Bircan Çeken Toptanci, Göksel Kızıl, Murat Kızıl
CONTEXT: Hertia cheirifolia L. (Asteraceae), a perennial shrub widely distributed in Northern Africa, is traditionally used to treat inflammatory disorders. OBJECTIVE: The protective effect of methanol (Met E) and aqueous (Aq E) extracts of Hertia cheirifolia against DNA, lipid and protein oxidation was investigated. MATERIALS AND METHODS: Different concentrations (50-1000 μg/mL) of Hertia cheirifolia aerial part extracts were examined against DNA, lipid and protein oxidation induced by H2O2 + UV, FeSO4, and Fe(3+)/H2O2-ascorbic acid, respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27925493/the-effect-of-freeze-drying-on-the-nutrient-polyphenol-and-oxidant-levels-of-breast-milk
#20
Mariela Valentina Cortez, Elio Andrés Soria
OBJECTIVES: Human milk banks need to extend the suitability of milk for breastfeeding, and for this technological advances are required. Our aim was to establish the capacity of freeze-drying to conserve milk properties without further oxidative deterioration. METHODS: One hundred sixteen healthy women participated from the city of Cordoba (Argentina). Proteins, glucose, triglycerides, polyphenols, and markers (nitrites, superoxide anion, hydroperoxides, lipoperoxides, and γ-glutamyl transpeptidase) were measured in their fresh milk...
December 2016: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
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