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https://www.readbyqxmd.com/read/27915033/survivin-controls-biogenesis-of-microrna-in-smokers-a-link-to-pathogenesis-of-rheumatoid-arthritis
#1
Karin M E Andersson, Minna Turkkila, Malin C Erlandsson, Apostolos Bossios, Sofia Töyrä Silfverswärd, Dan Hu, Linda Ekerljung, Carina Malmhäll, Howard L Weiner, Bo Lundbäck, Maria I Bokarewa
MicroRNAs (miRs) represent a part of epigenetic control of autoimmunity gaining increasing attention in rheumatoid arthritis (RA). Since cigarette smoking plays important role in RA pathogenesis and reprograms transcriptional profile of miRNAs, we ask if the onco-protein survivin, a novel biomarker of RA, may provide a link between smoking and miRNA. Studying survivin expression in leukocytes of 144 female RA patients we observed that smoking patients had higher survivin transcription and a remarkable spreading of survivin isoforms...
November 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27914771/overview-of-electronic-nicotine-delivery-systems-a-systematic-review
#2
REVIEW
Allison M Glasser, Lauren Collins, Jennifer L Pearson, Haneen Abudayyeh, Raymond S Niaura, David B Abrams, Andrea C Villanti
CONTEXT: Rapid developments in e-cigarettes, or electronic nicotine delivery systems (ENDS), and the evolution of the overall tobacco product marketplace warrant frequent evaluation of the published literature. The purpose of this article is to report updated findings from a comprehensive review of the published scientific literature on ENDS. EVIDENCE ACQUISITION: The authors conducted a systematic review of published empirical research literature on ENDS through May 31, 2016, using a detailed search strategy in the PubMed electronic database, expert review, and additional targeted searches...
November 30, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27914770/cigarette-smoking-and-mortality-in-adults-aged-70-years-and-older-results-from-the-nih-aarp-cohort
#3
Sarah H Nash, Linda M Liao, Tamara B Harris, Neal D Freedman
INTRODUCTION: Tobacco use remains a leading modifiable cause of cancer incidence and premature mortality in the U.S. and globally. Despite increasing life expectancy worldwide, less is known about the effects of cigarette smoking on older populations. This study sought to determine the effects of smoking on mortality in older age. METHODS: Associations of mortality with self-reported age at smoking cessation, age at smoking initiation, and amount smoked after age 70 years were examined in 160,113 participants of the NIH-AARP Diet and Health Study aged >70 years...
November 22, 2016: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27914516/leukotriene-b4-induces-emt-and-vimentin-expression-in-panc-1-pancreatic-cancer-cells-involvement-of-blt2-via-erk2-activation
#4
You Ri Kim, Mi Kyung Park, Gyeong Jin Kang, Hyun Ji Kim, Eun Ji Kim, Hyun Jung Byun, Moo-Yeol Lee, Chang Hoon Lee
Leukotriene B4 (LTB4) is a leukocyte chemoattractant and plays a major role controlling inflammatory responses including pancreatitis. LTB4 is known to be correlated with cancer progression. LTB4 induces keratin phosphorylation and reorganization by activating extracellular regulated kinase (ERK) in PANC-1 pancreatic cancer cell lines. However, the role of LTB4 in epithelial mesenchymal transition (EMT) and vimentin expression in pancreatic cancer cells is unknown. We examined whether LTB4 induces EMT and vimentin expression by Western blot, si-RNA, and RT-PCR...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27914289/metals-transfer-from-tobacco-to-cigarette-smoke-evidences-in-smokers-lung-tissue
#5
Edgar Pinto, Mariana Cruz, Patrícia Ramos, Agostinho Santos, Agostinho Almeida
Tobacco use kills millions of people every year around the world. The current level of 11 metals in tobacco was determined and their transfer rate to cigarette smoke was calculated as the difference between the total metal content in cigarettes and the amount present in its ashes. The metals content was also determined in the lung tissue of smokers and non-smokers in order to evaluate the marks that smoking leaves in this tissue. Metals content in tobacco ranged from less than 1μg/g (Co, Cd, Pb, As and Tl) to several hundreds of μg/g (Al, Mn and Ba)...
November 27, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27913790/do-cigarette-graphic-warnings-encourage-smokers-to-attend-a-smoking-cessation-programme-a-quasi-experimental-study
#6
Joseph Guydish, Barbara Tajima, Thao Le, Catherine Henderson, Deborah Yip, Valerie Gruber, Wayne Garcia, Kevin L Delucchi
OBJECTIVE: This study assessed whether exposure to cigarette graphic warning labels (GWLs) increased attendance to a smoking cessation programme. METHOD: From 2014 to 2016, alternating cohorts of smokers in 3 residential drug treatment programmes received either GWLs (experimental) or transparent (control) labels placed on their cigarette packs for 30 days. The primary outcome was the proportion of participants who chose to attend a smoking cessation group after the labelling period...
December 2, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27912918/the-use-of-potassium-hydroxide-koh-solution-as-a-suitable-approach-to-isolate-plastics-ingested-by-marine-organisms
#7
Susanne Kühn, Bernike van Werven, Albert van Oyen, André Meijboom, Elisa L Bravo Rebolledo, Jan A van Franeker
In studies of plastic ingestion by marine wildlife, visual separation of plastic particles from gastrointestinal tracts or their dietary content can be challenging. Earlier studies have used solutions to dissolve organic materials leaving synthetic particles unaffected. However, insufficient tests have been conducted to ensure that different categories of consumer products partly degraded in the environment and/or in gastrointestinal tracts were not affected. In this study 63 synthetic materials and 11 other dietary items and non-plastic marine debris were tested...
November 29, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27912830/advances-in-small-cell-lung-cancer
#8
REVIEW
Gregory P Kalemkerian, Bryan J Schneider
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor characterized by early metastatic spread and responsiveness to initial therapy. The incidence of SCLC has been declining in the United States in parallel with the decreasing prevalence of cigarette smoking. Limited stage disease is potentially curable with chemoradiotherapy followed by cranial irradiation. Extensive stage disease is incurable, but systemic chemotherapy can improve quality of life and prolong survival. Nearly all patients relapse with chemoresistant disease...
February 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27912076/activating-transcription-factor-3-is-essential-for-cigarette-smoke-induced-mucin-expression-via-interaction-with-activator-protein-1
#9
Yan-Ping Wu, Yin-Fang Wu, Chao Zhang, Hong-Bin Zhou, Chao Cao, Miao Li, Chen Zhu, Song-Min Ying, Zhi-Hua Chen, Hua-Hao Shen, Wen Li
Mucus hypersecretion is an important pathologic feature of chronic obstructive pulmonary disease. Activating transcription factor 3 (ATF3) is an adaptive-response gene that participates in various cellular processes. However, little is known about its role in cigarette smoke (CS)-induced mucus hyperproduction. This study aimed to investigate the role and molecular mechanisms of ATF3 in CS-induced Mucin 5AC (MUC5AC) expression. ATF3 was elevated in lung tissues of mice exposed to CS for 12 weeks. Treatment with CS extract significantly induced ATF3 expression and MUC5AC production in human bronchial epithelial cells, NCI-H292, and mouse tracheal epithelial cells...
November 29, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27911957/tristetraprolin-down-regulation-contributes-to-persistent-tnf-alpha-expression-induced-by-cigarette-smoke-extract-through-a-post-transcriptional-mechanism
#10
Xue-Ke Zhao, Pulin Che, Ming-Liang Cheng, Quan Zhang, Mao Mu, Hong Li, Yuan Luo, Yue-Dong Liang, Xin-Hua Luo, Chang-Qing Gao, Patricia L Jackson, J Michael Wells, Yong Zhou, Meng Hu, Guoqiang Cai, Victor J Thannickal, Chad Steele, J Edwin Blalock, Xiaosi Han, Ching-Yi Chen, Qiang Ding
RATIONALE: Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced TNF-α expression has not been determined. METHODS: TTP expression was examined by western blot analysis in murine alveolar macrophages and alveolar epithelial cells challenged without or with cigarette smoke extract (CSE)...
2016: PloS One
https://www.readbyqxmd.com/read/27909413/sex-effects-on-smoking-cue-perception-in-non-smokers-smokers-and-ex-smokers-a-pilot-study
#11
Davide Zanchi, Arthur Brody, Stefan Borgwardt, Sven Haller
INTRODUCTION: Recent neuroimaging research suggests sex-related brain differences in smoking addiction. In the present pilot study, we assessed gender-related differences in brain activation in response to cigarette-related video cues, investigating non-smokers, smokers, and ex-smokers. METHODS: First, we compared 29 females (28.6 ± 5.3) vs. 23 males (31.5 ± 6.4), regardless of current smoking status to assess global gender-related effects. Second, we performed a post hoc analysis of non-smokers (9 females and 8 males), smokers (10 females and 8 males), and ex-smokers (10 females and 7 males)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27908385/the-mutagenic-assessment-of-an-electronic-cigarette-and-reference-cigarette-smoke-using-the-ames-assay-in-strains-ta98-and-ta100
#12
D Thorne, I Crooks, M Hollings, A Seymour, C Meredith, M Gaca
Salmonella typhimurium strains TA98 and TA100 were used to assess the mutagenic potential of the aerosol from a commercially available, rechargeable, closed system electronic-cigarette. Results obtained were compared to those for the mainstream smoke from a Kentucky reference (3R4F) cigarette. Two different test matrices were assessed. Aerosol generated from the e-cigarette was trapped on a Cambridge filter pad, eluted in DMSO and compared to cigarette smoke total particulate matter (TPM), which was generated in the same manner for mutagenicity assessment in the Salmonella assay...
December 2016: Mutation Research
https://www.readbyqxmd.com/read/27908378/erratum-to-cigarette-smoke-induces-alterations-in-the-drug-binding-properties-of-human-serum-albumin-blood-cells-mol-dis-52-4-2014-apr-166-174
#13
M Clerici, G Colombo, F Secundo, N Gagliano, R Colombo, N Portinaro, D Giustarini, A Milzani, R Rossi, I Dalle-Donne
No abstract text is available yet for this article.
November 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27908296/smoking-in-pregnancy-adolescent-mental-health-and-cognitive-performance-in-young-adult-offspring-results-from-a-matched-sample-within-a-finnish-cohort
#14
Hugh Ramsay, Jennifer H Barnett, Graham K Murray, Pirjo Mäki, Tuula Hurtig, Tanja Nordström, Jouko Miettunen, Vesa Kiviniemi, Solja Niemelä, Zdenka Pausova, Tomas Paus, Juha Veijola
BACKGROUND: The association between prenatal exposure to maternal cigarette smoking (PEMCS) and adult cognition is debated, including if there are differences according to sex. We aimed to determine if there are associations between PEMCS and cognition in early adulthood in men and women and examine if observed associations were mediated by adolescent mental health factors that are associated with cognition, namely psychotic-like experiences (PLEs), inattention and hyperactivity, and other externalizing behaviors...
December 1, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27907070/modulation-by-ethanol-of-cigarette-smoke-clastogenicity-in-cells-of-adult-mice-and-of-transplacentally-exposed-fetuses
#15
Roumen Balansky, Sebastiano La Maestra, Rosanna T Micale, Marietta Iltcheva, Krassimir Kirov, Silvio De Flora
Cigarette smoke (CS) and ethanol (EtOH) are known to synergize in the causation of cancers of the upper aerodigestive tract and of the liver. Little is known about possible interactions between these agents in other organs. These premises prompted us to evaluate the clastogenic effects resulting from the inhalation for 3 weeks of mainstream CS and oral administration of EtOH, which were tested either individually or in combination in cells of adult BDF1 mice and their fetuses. CS exerted clastogenic effects in haematopoietic cells of adult male mice by increasing the frequency of micronucleated erythroid cells both in bone marrow and in peripheral blood as well as the frequency of micronucleated and polynucleated pulmonary alveolar macrophages...
2016: PloS One
https://www.readbyqxmd.com/read/27907022/nicotine-induces-podocyte-apoptosis-through-increasing-oxidative-stress
#16
Xiqian Lan, Rivka Lederman, Judith M Eng, Seyedeh Shadafarin Marashi Shoshtari, Moin A Saleem, Ashwani Malhotra, Pravin C Singhal
BACKGROUND: Cigarette smoking plays an important role in the progression of chronic kidney disease (CKD). Nicotine, one of the major components of cigarette smoking, has been demonstrated to increase proliferation of renal mesangial cells. In this study, we examined the effect of nicotine on podocyte injury. METHODS: To determine the expression of nicotinic acetylcholine receptors (nAChR subunits) in podocytes, cDNAs and cell lysate of cultured human podocytes were used for the expression of nAChR mRNAs and proteins, respectively; and mouse renal cortical sections were subjected to immunofluorescant staining...
2016: PloS One
https://www.readbyqxmd.com/read/27906858/electronic-cigarettes-as-smoking-cessation-tool-are-we-there
#17
Sohini Ghosh, M Bradley Drummond
PURPOSE OF REVIEW: Electronic cigarette (e-cigarette) use is rapidly increasing, with many users reporting trying e-cigarettes as a method to quit combustible cigarettes. This review highlights recently published studies assessing the use of e-cigarettes as a tool for cessation of combustible cigarettes. RECENT FINDINGS: When evaluating data from four randomized controlled trials and multiple cohort studies, differential association between e-cigarette use and cessation rates was seen...
November 30, 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27906737/safety-and-efficacy-of-electronic-cigarettes-update-for-the-clinical-nurse-specialist
#18
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27906728/safety-and-efficacy-of-electronic-cigarettes-update-for-the-clinical-nurse-specialist
#19
Patricia Anne O'Malley
No abstract text is available yet for this article.
January 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/27906087/legionella-pneumonia-in-the-niagara-region-ontario-canada-a-case-series
#20
Stephanie Cargnelli, Jeff Powis, Jennifer L Y Tsang
BACKGROUND: Legionella pneumophila, a major cause of Legionnaires' disease, accounts for 2-15 % of all community-acquired pneumonia requiring hospitalization and up to 30 % of community-acquired pneumonia requiring intensive care unit admission. Early initiation of appropriate antimicrobial therapy is a crucial step in the prevention of morbidity and mortality. However, recognition of Legionnaires' disease continues to be challenging because of its nonspecific clinical features. We sought to describe hospitalized community-acquired Legionnaires' disease to increase awareness of this important and potentially lethal disease...
December 1, 2016: Journal of Medical Case Reports
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