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https://www.readbyqxmd.com/read/29531051/opinion-is-science-really-facing-a-reproducibility-crisis-and-do-we-need-it-to
#1
Daniele Fanelli
Efforts to improve the reproducibility and integrity of science are typically justified by a narrative of crisis, according to which most published results are unreliable due to growing problems with research and publication practices. This article provides an overview of recent evidence suggesting that this narrative is mistaken, and argues that a narrative of epochal changes and empowerment of scientists would be more accurate, inspiring, and compelling.
March 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29460082/testing-hypotheses-on-risk-factors-for-scientific-misconduct-via-matched-control-analysis-of-papers-containing-problematic-image-duplications
#2
Daniele Fanelli, Rodrigo Costas, Ferric C Fang, Arturo Casadevall, Elisabeth M Bik
It is commonly hypothesized that scientists are more likely to engage in data falsification and fabrication when they are subject to pressures to publish, when they are not restrained by forms of social control, when they work in countries lacking policies to tackle scientific misconduct, and when they are male. Evidence to test these hypotheses, however, is inconclusive due to the difficulties of obtaining unbiased data. Here we report a pre-registered test of these four hypotheses, conducted on papers that were identified in a previous study as containing problematic image duplications through a systematic screening of the journal PLoS ONE...
February 19, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29449312/prevalence-and-prognostic-impact-of-diabetes-in-takotsubo-syndrome-insights-from-the-international-multicenter-geist-registry
#3
Thomas Stiermaier, Francesco Santoro, Ibrahim El-Battrawy, Christian Möller, Tobias Graf, Giuseppina Novo, Andrea Santangelo, Enrica Mariano, Francesco Romeo, Pasquale Caldarola, Mario Fanelli, Holger Thiele, Natale Daniele Brunetti, Ibrahim Akin, Ingo Eitel
OBJECTIVE: In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. RESEARCH DESIGN AND METHODS: A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany)...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29440066/data-sharing-and-reanalysis-of-randomized-controlled-trials-in-leading-biomedical-journals-with-a-full-data-sharing-policy-survey-of-studies-published-in-the-bmj-and-plos-medicine
#4
REVIEW
Florian Naudet, Charlotte Sakarovitch, Perrine Janiaud, Ioana Cristea, Daniele Fanelli, David Moher, John P A Ioannidis
OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes. DESIGN: Survey of published RCTs. SETTING: PubMed/Medline. ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals...
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29369337/improving-the-integrity-of-published-science-an-expanded-taxonomy-of-retractions-and-corrections
#5
Daniele Fanelli, John Pa Ioannidis, Steven Goodman
Policies and practices to correct and retract scientific articles suffer from numerous limitations that are increasingly discussed in the literature. We briefly summarize these issues and propose a new and unified taxonomy of amendment types. The proposed 13-category system both simplifies and expands existing classifications and may be used as a heuristic tool to retrospectively classify literature amendments, as a taxonomy for electronic tagging, and as a blueprint for new amendment formats that journal editors could experiment with...
January 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29204892/erratum-to-hplc-determination-of-bioactive-sulfur-compounds-amino-acids-and-biogenic-amines-in-biological-specimens
#6
Antonio Francioso, Sergio Fanelli, Daniele Vigli, Laura Ricceri, Rosaria A Cavallaro, Alessia Baseggio Conrado, Mario Fontana, Maria D'Erme, Luciana Mosca
No abstract text is available yet for this article.
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28815787/evaluation-of-incidence-significance-and-prognostic-role-of-circulating-tumor-microemboli-and-transforming-growth-factor-%C3%AE-receptor-i-in-head-and-neck-cancer
#7
Marcello Ferretti Fanelli, Thiago Bueno Oliveira, Alexcia Camila Braun, Marcelo Corassa, Emne Ali Abdallah, Ulisses Ribaldo Nicolau, Vanessa da Silva Alves, Daniel Garcia, Vinicius F Calsavara, Luiz Paulo Kowalski, Ludmilla Thomé Domingos Chinen
BACKGROUND: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-β (TGF-β). The purpose of this study was to verify their role in progression-free survival (PFS). METHODS: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n = 53) was analyzed in 2 moments. TGF-β receptor I (TGF-βRI) expression was evaluated by immunocytochemistry...
November 2017: Head & Neck
https://www.readbyqxmd.com/read/28337643/recombinant-heat-shock-protein-27-hsp27-hspb1-protects-against-cadmium-induced-oxidative-stress-and-toxicity-in-human-cervical-cancer-cells
#8
Daiana G Alvarez-Olmedo, Veronica S Biaggio, Geremy A Koumbadinga, Nidia N Gómez, Chunhua Shi, Daniel R Ciocca, Zarah Batulan, Mariel A Fanelli, Edward R O'Brien
Cadmium (Cd) is a carcinogen with several well-described toxicological effects in humans, but its molecular mechanisms are still not fully understood. Overexpression of heat shock protein 27 (HSP27/HSPB1)-a multifunctional protein chaperone-has been shown to protect cells from oxidative damage and apoptosis triggered by Cd exposure. The aims of this work were to investigate the potential use of extracellular recombinant HSP27 to prevent/counteract Cd-induced cellular toxicity and to evaluate if peroxynitrite was involved in the development of Cd-induced toxicity...
May 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28321689/doing-the-right-thing-a-qualitative-investigation-of-retractions-due-to-unintentional-error
#9
Mohammad Hosseini, Medard Hilhorst, Inez de Beaufort, Daniele Fanelli
Retractions solicited by authors following the discovery of an unintentional error-what we henceforth call a "self-retraction"-are a new phenomenon of growing importance, about which very little is known. Here we present results of a small qualitative study aimed at gaining preliminary insights about circumstances, motivations and beliefs that accompanied the experience of a self-retraction. We identified retraction notes that unambiguously reported an honest error and that had been published between the years 2010 and 2015...
February 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28320937/meta-assessment-of-bias-in-science
#10
Daniele Fanelli, Rodrigo Costas, John P A Ioannidis
Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated bias-related patterns and risk factors, in a large random sample of meta-analyses taken from all disciplines. The magnitude of these biases varied widely across fields and was overall relatively small. However, we consistently observed a significant risk of small, early, and highly cited studies to overestimate effects and of studies not published in peer-reviewed journals to underestimate them...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28067604/central-hypogonadism-due-to-a-giant-silent-fsh-secreting-atypical-pituitary-adenoma-effects-of-adenoma-dissection-and-short-term-leydig-cell-stimulation-by-luteinizing-hormone-lh-and-human-chorionic-gonadotropin-hcg
#11
Daniele Santi, Giorgia Spaggiari, Livio Casarini, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Antonio R M Granata, Cesare Carani, Manuela Simoni
We present a case report of an atypical giant pituitary adenoma secreting follicle-stimulating hormone (FSH). A 55-year-old patient presented for erectile dysfunction, loss of libido and fatigue. The biochemical evaluation showed very high FSH serum levels in the presence of central hypogonadism. Neither testicular enlargement nor increased sperm count was observed, thus a secretion of FSH with reduced biological activity was supposed. The histological examination after neuro-surgery showed an atypical pituitary adenoma with FSH-positive cells...
June 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27270074/posterior-reversible-encephalopathy-syndrome-in-acute-pancreatitis-a-case-report
#12
Christian Compagnone, Daniele Bellantonio, Federica Pavan, Fernanda Tagliaferri, Maria Barbagallo, Guido Fanelli
No abstract text is available yet for this article.
June 7, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27252173/what-does-research-reproducibility-mean
#13
REVIEW
Steven N Goodman, Daniele Fanelli, John P A Ioannidis
The language and conceptual framework of "research reproducibility" are nonstandard and unsettled across the sciences. In this Perspective, we review an array of explicit and implicit definitions of reproducibility and related terminology, and discuss how to avoid potential misunderstandings when these terms are used as a surrogate for "truth."
June 1, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27100958/takotsubo-cardiomyopathy-and-betablockers-on-the-wall-of%C3%A2-the-cave-only-the-shadows-are-true
#14
LETTER
Francesco Santoro, Riccardo Ieva, Armando Ferraretti, Mario Fanelli, Francesco Musaico, Nicola Tarantino, Luigi Di Martino, Luisa De Gennaro, Pasquale Caldarola, Matteo Di Biase, Natale Daniele Brunetti
No abstract text is available yet for this article.
August 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27008933/set-up-a-self-retraction-system-for-honest-errors
#15
Daniele Fanelli
No abstract text is available yet for this article.
March 24, 2016: Nature
https://www.readbyqxmd.com/read/26960191/researchers-individual-publication-rate-has-not-increased-in-a-century
#16
Daniele Fanelli, Vincent Larivière
Debates over the pros and cons of a "publish or perish" philosophy have inflamed academia for at least half a century. Growing concerns, in particular, are expressed for policies that reward "quantity" at the expense of "quality," because these might prompt scientists to unduly multiply their publications by fractioning ("salami slicing"), duplicating, rushing, simplifying, or even fabricating their results. To assess the reasonableness of these concerns, we analyzed publication patterns of over 40,000 researchers that, between the years 1900 and 2013, have published two or more papers within 15 years, in any of the disciplines covered by the Web of Science...
2016: PloS One
https://www.readbyqxmd.com/read/26950035/mrp1-expression-in-ctcs-confers-resistance-to-irinotecan-based-chemotherapy-in-metastatic-colorectal-cancer
#17
Emne Ali Abdallah, Marcello Ferretti Fanelli, Virgílio Souza E Silva, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Daniel Vilarim Araújo, Luciana Menezes Mendonça Ocea, Marcilei Eliza Cavicchioli Buim, Milena Shizue Tariki, Vanessa da Silva Alves, Victor Piana de Andrade, Aldo Lourenço Abbade Dettino, Celso Abdon Lopes de Mello, Ludmilla Thomé Domingos Chinen
Circulating tumor cells are important markers of tumor progression and can reflect tumor behavior in metastatic colorectal cancer (mCRC). Identification of proteins that confer resistance to treatment is an important step to predict response and better selection of treatment for patients. Multidrug resistance-associated protein 1 (MRP1) and Multidrug resistance-associated protein 4 (MRP4) play a role in irinotecan-resistance, and Excision Repair Cross-Complementation group 1 (ERCC1) expression can confer resistance to platinum compounds...
August 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26946520/hemodynamic-effects-safety-and-feasibility-of-intravenous-esmolol-infusion-during-takotsubo-cardiomyopathy-with-left-ventricular-outflow-tract-obstruction-results-from-a-multicenter-registry
#18
MULTICENTER STUDY
Francesco Santoro, Riccardo Ieva, Armando Ferraretti, Mario Fanelli, Francesco Musaico, Nicola Tarantino, Luigi Di Martino, Luisa De Gennaro, Pasquale Caldarola, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: Left ventricular outflow tract obstruction (LVOTO) may complicate an episode of Takotsubo cardiomyopathy (TTC), potentially leading to cardiogenic shock. Beta-blockers are considered the most suitable treatment for such complication. AIM OF THE STUDY: The objective of this study was to evaluate the hemodynamic effects, safety, and feasibility of a selective beta-blocker (β1) with a short half-life, esmolol, in subjects with a TTC episode. METHODS: Ninety-six consecutive patients with TTC were enrolled in a multicenter registry...
June 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/26901834/conservative-tests-under-satisficing-models-of-publication-bias
#19
Justin McCrary, Garret Christensen, Daniele Fanelli
Publication bias leads consumers of research to observe a selected sample of statistical estimates calculated by producers of research. We calculate critical values for statistical significance that could help to adjust after the fact for the distortions created by this selection effect, assuming that the only source of publication bias is file drawer bias. These adjusted critical values are easy to calculate and differ from unadjusted critical values by approximately 50%-rather than rejecting a null hypothesis when the t-ratio exceeds 2, the analysis suggests rejecting a null hypothesis when the t-ratio exceeds 3...
2016: PloS One
https://www.readbyqxmd.com/read/26849387/knee-injury-associated-with-acetabular-fractures-a-multicenter-study-of-1273-patients
#20
MULTICENTER STUDY
Harish Kempegowda, Hemil H Maniar, Akhil A Tawari, Gregory C Fanelli, Clifford B Jones, Debra L Sietsema, Yelena Bogdan, Paul Tornetta, Andrew J Marcantonio, Daniel S Horwitz
OBJECTIVES: The purpose of this study was to determine the incidence and pattern of the knee injury associated with acetabular fractures. DESIGN: Retrospective cohort study. SETTING: Three level I and one level II trauma centers. PATIENTS: A total of 1273 skeletally mature patients treated at 4 trauma centers between November 2004 and December 2013 for acetabular fractures were retrospectively identified from orthopaedic trauma databases...
January 2016: Journal of Orthopaedic Trauma
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