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Daniele fanelli

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https://www.readbyqxmd.com/read/28337643/recombinant-heat-shock-protein-27-hsp27-hspb1-protects-against-cadmium-induced-oxidative-stress-and-toxicity-in-human-cervical-cancer-cells
#1
Daiana G Alvarez-Olmedo, Veronica S Biaggio, Geremy A Koumbadinga, Nidia N Gómez, Chunhua Shi, Daniel R Ciocca, Zarah Batulan, Mariel A Fanelli, Edward R O'Brien
Cadmium (Cd) is a carcinogen with several well-described toxicological effects in humans, but its molecular mechanisms are still not fully understood. Overexpression of heat shock protein 27 (HSP27/HSPB1)-a multifunctional protein chaperone-has been shown to protect cells from oxidative damage and apoptosis triggered by Cd exposure. The aims of this work were to investigate the potential use of extracellular recombinant HSP27 to prevent/counteract Cd-induced cellular toxicity and to evaluate if peroxynitrite was involved in the development of Cd-induced toxicity...
May 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28321689/doing-the-right-thing-a-qualitative-investigation-of-retractions-due-to-unintentional-error
#2
Mohammad Hosseini, Medard Hilhorst, Inez de Beaufort, Daniele Fanelli
Retractions solicited by authors following the discovery of an unintentional error-what we henceforth call a "self-retraction"-are a new phenomenon of growing importance, about which very little is known. Here we present results of a small qualitative study aimed at gaining preliminary insights about circumstances, motivations and beliefs that accompanied the experience of a self-retraction. We identified retraction notes that unambiguously reported an honest error and that had been published between the years 2010 and 2015...
March 20, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28320937/meta-assessment-of-bias-in-science
#3
Daniele Fanelli, Rodrigo Costas, John P A Ioannidis
Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated bias-related patterns and risk factors, in a large random sample of meta-analyses taken from all disciplines. The magnitude of these biases varied widely across fields and was overall relatively small. However, we consistently observed a significant risk of small, early, and highly cited studies to overestimate effects and of studies not published in peer-reviewed journals to underestimate them...
April 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28067604/central-hypogonadism-due-to-a-giant-silent-fsh-secreting-atypical-pituitary-adenoma-effects-of-adenoma-dissection-and-short-term-leydig-cell-stimulation-by-luteinizing-hormone-lh-and-human-chorionic-gonadotropin-hcg
#4
Daniele Santi, Giorgia Spaggiari, Livio Casarini, Flaminia Fanelli, Marco Mezzullo, Uberto Pagotto, Antonio R M Granata, Cesare Carani, Manuela Simoni
We present a case report of an atypical giant pituitary adenoma secreting follicle-stimulating hormone (FSH). A 55-year-old patient presented for erectile dysfunction, loss of libido and fatigue. The biochemical evaluation showed very high FSH serum levels in the presence of central hypogonadism. Neither testicular enlargement nor increased sperm count was observed, thus a secretion of FSH with reduced biological activity was supposed. The histological examination after neuro-surgery showed an atypical pituitary adenoma with FSH-positive cells...
June 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/27270074/posterior-reversible-encephalopathy-syndrome-in-acute-pancreatitis-a-case-report
#5
Christian Compagnone, Daniele Bellantonio, Federica Pavan, Fernanda Tagliaferri, Maria Barbagallo, Guido Fanelli
No abstract text is available yet for this article.
June 7, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27252173/what-does-research-reproducibility-mean
#6
REVIEW
Steven N Goodman, Daniele Fanelli, John P A Ioannidis
The language and conceptual framework of "research reproducibility" are nonstandard and unsettled across the sciences. In this Perspective, we review an array of explicit and implicit definitions of reproducibility and related terminology, and discuss how to avoid potential misunderstandings when these terms are used as a surrogate for "truth."
June 1, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27100958/takotsubo-cardiomyopathy-and-betablockers-on-the-wall-of%C3%A2-the-cave-only-the-shadows-are-true
#7
LETTER
Francesco Santoro, Riccardo Ieva, Armando Ferraretti, Mario Fanelli, Francesco Musaico, Nicola Tarantino, Luigi Di Martino, Luisa De Gennaro, Pasquale Caldarola, Matteo Di Biase, Natale Daniele Brunetti
No abstract text is available yet for this article.
August 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27008933/set-up-a-self-retraction-system-for-honest-errors
#8
Daniele Fanelli
No abstract text is available yet for this article.
March 24, 2016: Nature
https://www.readbyqxmd.com/read/26960191/researchers-individual-publication-rate-has-not-increased-in-a-century
#9
Daniele Fanelli, Vincent Larivière
Debates over the pros and cons of a "publish or perish" philosophy have inflamed academia for at least half a century. Growing concerns, in particular, are expressed for policies that reward "quantity" at the expense of "quality," because these might prompt scientists to unduly multiply their publications by fractioning ("salami slicing"), duplicating, rushing, simplifying, or even fabricating their results. To assess the reasonableness of these concerns, we analyzed publication patterns of over 40,000 researchers that, between the years 1900 and 2013, have published two or more papers within 15 years, in any of the disciplines covered by the Web of Science...
2016: PloS One
https://www.readbyqxmd.com/read/26950035/mrp1-expression-in-ctcs-confers-resistance-to-irinotecan-based-chemotherapy-in-metastatic-colorectal-cancer
#10
Emne Ali Abdallah, Marcello Ferretti Fanelli, Virgílio Souza E Silva, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Daniel Vilarim Araújo, Luciana Menezes Mendonça Ocea, Marcilei Eliza Cavicchioli Buim, Milena Shizue Tariki, Vanessa da Silva Alves, Victor Piana de Andrade, Aldo Lourenço Abbade Dettino, Celso Abdon Lopes de Mello, Ludmilla Thomé Domingos Chinen
Circulating tumor cells are important markers of tumor progression and can reflect tumor behavior in metastatic colorectal cancer (mCRC). Identification of proteins that confer resistance to treatment is an important step to predict response and better selection of treatment for patients. Multidrug resistance-associated protein 1 (MRP1) and Multidrug resistance-associated protein 4 (MRP4) play a role in irinotecan-resistance, and Excision Repair Cross-Complementation group 1 (ERCC1) expression can confer resistance to platinum compounds...
August 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/26946520/hemodynamic-effects-safety-and-feasibility-of-intravenous-esmolol-infusion-during-takotsubo-cardiomyopathy-with-left-ventricular-outflow-tract-obstruction-results-from-a-multicenter-registry
#11
MULTICENTER STUDY
Francesco Santoro, Riccardo Ieva, Armando Ferraretti, Mario Fanelli, Francesco Musaico, Nicola Tarantino, Luigi Di Martino, Luisa De Gennaro, Pasquale Caldarola, Matteo Di Biase, Natale Daniele Brunetti
BACKGROUND: Left ventricular outflow tract obstruction (LVOTO) may complicate an episode of Takotsubo cardiomyopathy (TTC), potentially leading to cardiogenic shock. Beta-blockers are considered the most suitable treatment for such complication. AIM OF THE STUDY: The objective of this study was to evaluate the hemodynamic effects, safety, and feasibility of a selective beta-blocker (β1) with a short half-life, esmolol, in subjects with a TTC episode. METHODS: Ninety-six consecutive patients with TTC were enrolled in a multicenter registry...
June 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/26901834/conservative-tests-under-satisficing-models-of-publication-bias
#12
Justin McCrary, Garret Christensen, Daniele Fanelli
Publication bias leads consumers of research to observe a selected sample of statistical estimates calculated by producers of research. We calculate critical values for statistical significance that could help to adjust after the fact for the distortions created by this selection effect, assuming that the only source of publication bias is file drawer bias. These adjusted critical values are easy to calculate and differ from unadjusted critical values by approximately 50%-rather than rejecting a null hypothesis when the t-ratio exceeds 2, the analysis suggests rejecting a null hypothesis when the t-ratio exceeds 3...
2016: PloS One
https://www.readbyqxmd.com/read/26849387/knee-injury-associated-with-acetabular-fractures-a-multicenter-study-of-1273-patients
#13
MULTICENTER STUDY
Harish Kempegowda, Hemil H Maniar, Akhil A Tawari, Gregory C Fanelli, Clifford B Jones, Debra L Sietsema, Yelena Bogdan, Paul Tornetta, Andrew J Marcantonio, Daniel S Horwitz
OBJECTIVES: The purpose of this study was to determine the incidence and pattern of the knee injury associated with acetabular fractures. DESIGN: Retrospective cohort study. SETTING: Three level I and one level II trauma centers. PATIENTS: A total of 1273 skeletally mature patients treated at 4 trauma centers between November 2004 and December 2013 for acetabular fractures were retrospectively identified from orthopaedic trauma databases...
January 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/26806176/renal-impairment-and-outcome-in-patients-with-takotsubo-cardiomyopathy
#14
Francesco Santoro, Armando Ferraretti, Riccardo Ieva, Francesco Musaico, Mario Fanelli, Nicola Tarantino, Maria Scarcia, Pasquale Caldarola, Matteo Di Biase, Natale Daniele Brunetti
OBJECTIVES: The objectives were to ascertain the prevalence of renal impairment among patients with a takotsubo cardiomyopathy (TTC) episode and whether clinical outcomes are related to renal function. METHODS: A total of 108 consecutive subjects with TTC were enrolled in a multicenter registry and followed for a mean period of 429 days. Renal function was evaluated during hospitalization in terms of acute kidney injury/failure and estimated glomerular filtration rate (eGFR)...
March 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26780136/insecticide-concentrations-in-stream-sediments-of-soy-production-regions-of-south-america
#15
Lisa Hunt, Carlos Bonetto, Vincent H Resh, Daniel Forsin Buss, Silvia Fanelli, Natalia Marrochi, Michael J Lydy
Concentrations of 17 insecticides were measured in sediments collected from 53 streams in soy production regions of South America (Argentina in 2011-2014, Paraguay and Brazil in 2013) during peak application periods. Although environmental regulations are quite different in each country, commonly used insecticides were detected at high frequencies in all regions. Maximum concentrations (and detection frequencies) for each sampling event ranged from: 1.2-7.4 ng/g dw chlorpyrifos (56-100%); 0.9-8.3 ng/g dw cypermethrin (20-100%); 0...
March 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26246976/on-the-challenges-of-drawing-conclusions-from-p-values-just-below-0-05
#16
Daniël Lakens
In recent years, researchers have attempted to provide an indication of the prevalence of inflated Type 1 error rates by analyzing the distribution of p-values in the published literature. De Winter & Dodou (2015) analyzed the distribution (and its change over time) of a large number of p-values automatically extracted from abstracts in the scientific literature. They concluded there is a 'surge of p-values between 0.041-0.049 in recent decades' which 'suggests (but does not prove) questionable research practices have increased over the past 25 years...
2015: PeerJ
https://www.readbyqxmd.com/read/26245138/turing-instabilities-on-cartesian-product-networks
#17
Malbor Asllani, Daniel M Busiello, Timoteo Carletti, Duccio Fanelli, Gwendoline Planchon
The problem of Turing instabilities for a reaction-diffusion system defined on a complex Cartesian product network is considered. To this end we operate in the linear regime and expand the time dependent perturbation on a basis formed by the tensor product of the eigenvectors of the discrete Laplacian operators, associated to each of the individual networks that build the Cartesian product. The dispersion relation which controls the onset of the instability depends on a set of discrete wavelengths, the eigenvalues of the aforementioned Laplacians...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26083381/misconduct-policies-academic-culture-and-career-stage-not-gender-or-pressures-to-publish-affect-scientific-integrity
#18
Daniele Fanelli, Rodrigo Costas, Vincent Larivière
The honesty and integrity of scientists is widely believed to be threatened by pressures to publish, unsupportive research environments, and other structural, sociological and psychological factors. Belief in the importance of these factors has inspired major policy initiatives, but evidence to support them is either non-existent or derived from self-reports and other sources that have known limitations. We used a retrospective study design to verify whether risk factors for scientific misconduct could predict the occurrence of retractions, which are usually the consequence of research misconduct, or corrections, which are honest rectifications of minor mistakes...
2015: PloS One
https://www.readbyqxmd.com/read/25721610/thymidylate-synthase-expression-in-circulating-tumor-cells-a-new-tool-to-predict-5-fluorouracil-resistance-in-metastatic-colorectal-cancer-patients
#19
Emne Ali Abdallah, Marcello Ferretti Fanelli, Marcilei Eliza Cavicchioli Buim, Marcelo Calil Machado Netto, José Luiz Gasparini Junior, Virgílio Souza E Silva, Aldo Lourenço Abbade Dettino, Natalia Breve Mingues, Juliana Valim Romero, Luciana Menezes Mendonça Ocea, Bruna Maria Malagoli Rocha, Vanessa Silva Alves, Daniel Vilarim Araújo, Ludmilla Thomé Domingos Chinen
Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemotherapy. The blood was filtered on Isolation by Size of Epithelial Tumor Cells (ISET), and the analysis of TYMS expression in CTCs was made by immunocytochemistry. Additionally, we verified TYMS staining in primary tumors and metastases from the same patients...
September 15, 2015: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/25515827/we-need-more-research-on-causes-and-consequences-as-well-as-on-solutions
#20
Daniele Fanelli
No abstract text is available yet for this article.
January 2015: Addiction
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