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Rapid tranquilization

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https://www.readbyqxmd.com/read/29582598/-rapid-screening-of-24-tranquillizer-drugs-in-fish-and-fishery-products-by-ultra-high-performance-liquid-chromatography-quadrupole-electrostatic-field-orbitrap-high-resolution-mass-spectroscopy
#1
Rong Li, Luqi Yang, Pengyun Zhang, Yangdan Luo, Pengjie Zhang, Yongqing Gao
A method was developed for the simultaneous determination of 24 tranquillizer drugs in fish and fishery products using ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry (UPLC-Q-Orbitrap HRMS). The samples were extracted with acetonitrile. Then, the extracts were concentrated, dissolved by 50% (v/v) methanol aqueous solution, cleaned up with hexane saturated by acetonitrile. The separation was performed on an ACQUITY UPLC® BEH C18 column (100 mm×2...
February 8, 2018: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29556047/intermittent-dynamics-in-complex-systems-driven-to-depletion
#2
Juan V Escobar, Isaac Pérez Castillo
When complex systems are driven to depletion by some external factor, their non-stationary dynamics can present an intermittent behaviour between relative tranquility and burst of activity whose consequences are often catastrophic. To understand and ultimately be able to predict such dynamics, we propose an underlying mechanism based on sharp thresholds of a local generalized energy density that naturally leads to negative feedback. We find a transition from a continuous regime to an intermittent one, in which avalanches can be predicted despite the stochastic nature of the process...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29431294/rapid-tranquilization-an-audit-of-irish-mental-health-nursing-practice
#3
Michael Nash, Caitriona McDonagh, Aisling Culhane, Imelda Noone, Agnes Higgins
Rapid tranquillization is a pharmacological intervention sometimes employed in mental health care for the management of acute behavioural disturbance. It is a form of restrictive practice, which, along with seclusion and restraint, is a conventional and controversial intervention in the therapeutic management of risk in mental health settings. This study surveyed mental health nurses practice in rapid tranquillization. A self-report questionnaire was utilized which addressed aspects such as definitions of rapid tranquillization, presence of rapid tranquillization policy, types of incidents where it is used and postintervention monitoring...
February 12, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29402071/sleep-disturbances-as-a-risk-factor-for-stroke
#4
REVIEW
Dae Lim Koo, Hyunwoo Nam, Robert J Thomas, Chang-Ho Yun
Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during NREM sleep is characterized by vagal dominance and stable breathing, providing an opportunity for the cardiovascular-neural axis to restore homeostasis, in response to use, distress or fatigue inflicted during wakefulness. Abrupt irregular swings in sympathovagal balance during REM sleep act as phasic loads on the resting cardiovascular system...
January 2018: Journal of Stroke
https://www.readbyqxmd.com/read/29308601/aripiprazole-intramuscular-for-psychosis-induced-aggression-or-agitation-rapid-tranquillisation
#5
REVIEW
Edoardo G Ostinelli, Salwan Jajawi, Styliani Spyridi, Kamlaj Sayal, Mahesh B Jayaram
BACKGROUND: People experiencing psychosis may become aggressive. Antipsychotics, such as aripiprazole in intramuscular form, can be used in such situations. OBJECTIVES: To evaluate the effects of intramuscular aripiprazole in the treatment of psychosis-induced aggression or agitation (rapid tranquillisation). SEARCH METHODS: On 11 December 2014 and 11 April 2017, we searched the Cochrane Schizophrenia Group's Study-based Register of Trials which is based on regular searches of CINAHL, BIOSIS, AMED, Embase, PubMed, MEDLINE, PsycINFO, and registries of clinical trials...
January 8, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29275617/-treatment-of-patients-with-different-degree-of-acute-respiratory-distress-syndrome-caused-by-inhalation-of-white-smoke
#6
F W Yang, H M Xin, J H Zhu, X Y Feng, X C Jiang, Z Y Gong, Y L Tong
Objective: To summarize the treatment experience of patients with different degree of acute respiratory distress syndrome (ARDS) caused by inhalation of white smoke from burning smoke bomb. Methods: A batch of 13 patients with different degree of ARDS caused by inhalation of white smoke from burning smoke bomb, including 2 patients complicated by pulmonary fibrosis at the late stage, were admitted to our unit in February 2016. Patients were divided into mild (9 cases), moderate (2 cases), and serious (2 cases) degree according to the ARDS Berlin diagnostic criteria...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29114529/rehabilitation-training-in-artificially-heated-environment
#7
Ping-Chung Leung
Sauna has become a popular club house facility where the dweller enjoys relaxation. Some exercise groups like yoga and Qigong practitioners, are making use of the heated environment to achieve quicker and better results of trainings. Sauna therapy is producing a thermal stress through hyperthermia. The cardiovascular system readily responds by increasing the heart rate which can become double the resting stage within minutes and cardiac output may have a 70% increase. The body's surface response to heat leads to a 40% of decrease in peripheral vascular resistance, thus allowing rapid peripheral blood flow which is responsible for greater heat dispersal directly from the skin...
October 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29048813/-determination-of-three-tranquillizer-residues-in-animal-foods-by-quechers-high-performance-liquid-chromatography-tandem-mass-spectrometry
#8
You Zou, Linzhi Shao, Simin Chen, Shaolun Ouyang, Feng Lin
A method for simultaneous determination of chlorpromazine, diazepam and metolazone residues in porcine muscle, fish, liver and kidney was developed using QuEChERS and HPLC-MS/MS technique. The samples were extracted with ethyl acetate and cleaned up with C18, N-propylethylendiamine (PSA) and NH2 sorbents after using Na2SO4 as dehydrating agent. The analytes were separated by a special C18 column, Atlantis T3, and gradiently eluted with a mixed solution of 5 mmol/L formic acid and acetonitrile at a flow rate of 0...
August 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/28981253/high-throughput-screening-method-for-systematic-surveillance-of-drugs-of-abuse-by-multisegment-injection-capillary-electrophoresis-mass-spectrometry
#9
Alicia DiBattista, Dianne Rampersaud, Howard Lee, Marcus Kim, Philip Britz-McKibbin
New technologies are urgently required for reliable drug screening given a worldwide epidemic of prescription drug abuse and its devastating socioeconomic impacts on public health. Primary screening of drugs of abuse (DoA) currently relies on immunoassays that are prone to bias and are not applicable to detect an alarming array of psychoactive stimulants, tranquilizers, and synthetic opioids. These limitations impact patient safety when monitoring for medication compliance, drug substitution, or misuse/abuse and require follow-up confirmatory testing by more specific yet lower throughput instrumental methods...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28758203/haloperidol-for-psychosis-induced-aggression-or-agitation-rapid-tranquillisation
#10
REVIEW
Edoardo G Ostinelli, Melanie J Brooke-Powney, Xue Li, Clive E Adams
BACKGROUND: Haloperidol used alone is recommended to help calm situations of aggression or agitation for people with psychosis. It is widely accessible and may be the only antipsychotic medication available in limited-resource areas. OBJECTIVES: To examine whether haloperidol alone is an effective treatment for psychosis-induced aggression or agitation, wherein clinicians are required to intervene to prevent harm to self and others. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Study-Based Register of Trials (26th May 2016)...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28577066/comparison-of-the-psychopharmacological-effects-of-tiletamine-and-ketamine-in-rodents
#11
Piotr Popik, Małgorzata Hołuj, Tomasz Kos, Gabriel Nowak, Tadeusz Librowski, Kinga Sałat
The glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine (KET) produces rapid and sustained antidepressant effects in patients. Tiletamine (TIL; 2-ethylamino-2-thiophen-2-yl-cyclohexan-1-one) is another uncompetitive NMDA receptor antagonist, used in a medical (veterinary) setting as an anesthetic tranquilizer. Here, we compared the behavioral actions of KET and TIL in a variety of tests, focusing on antidepressant-like and dissociative-like effects in mice and rats. The minimum effective doses of KET and TIL were 10 mg/kg to reduce mouse forced swim test immobility and 15 mg/kg to reduce marble-burying behavior...
November 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28275892/rapid-tranquilization-for-psychiatric-patients-with-psychomotor-agitation-what-is-known-about-it
#12
Clayton Gonçalves de Almeida, Mariana Del Grossi Moura, Silvio Barberato-Filho, Fernando de Sá Del Fiol, Rogério Heládio Lopes Motta, Cristiane de Cássia Bergamaschi
Rapid tranquilization is an intervention used in control of agitation or aggression in patients with mental disorders. This study synthesized the available evidence regarding efficacy and safety of drugs used for rapid tranquilization in psychiatric patients with psychomotor agitation. It is an overview study of systematic reviews and meta-analysis of randomized controlled trials (RCT) identified in the database MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library and LILACS until April 2015. A team of reviewers, in pairs and independently, identified eligible studies and assessed methodological quality using AMSTAR...
December 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/27966090/multiresidue-screening-of-veterinary-drugs-in-meat-milk-egg-and-fish-using-liquid-chromatography-coupled-with-ion-trap-time-of-flight-mass-spectrometry
#13
JeongWoo Kang, Su-Jeong Park, Hae-Chul Park, Md Akil Hossain, Myeong-Ae Kim, Seong-Wan Son, Chae-Mi Lim, Tae-Wan Kim, Byung-Hoon Cho
New approaches to veterinary drug screening based on liquid chromatography-mass spectrometry (LC-MS/MS) and time-of-flight mass spectrometry (ToF/MS) are rapid and have high selectivity and sensitivity. In this study, we developed a multiresidue method for screening over 100 veterinary drug residues using ion trap (IT)-ToF/MS. The screened compounds comprised major drug classes used in veterinary practice, representing the following: amphenicols, anthelmintics, benzimidazoles, β-lactams, coccidiostats, ionophores, macrolides, non-steroidal anti-inflammatory drugs, quinolones, sulfonamides, tetracyclines, and tranquilizers...
June 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27912882/tenuifolin-a-saponin-derived-from-radix-polygalae-exhibits-sleep-enhancing-effects-in-mice
#14
Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang
BACKGROUND: Radix Polygalae, the dried root of Polygala tenuifolia, has been extensively used as a traditional Chinese medicine for promoting intelligence and tranquilization. Polygalasaponins extracted from the root of P. tenuifolia possess evident anxiolytic and sedative-hypnotic activities. Previous studies have reported that tenuifolin was a major constituent of polygalasaponins. PURPOSE: The currently study aims to investigate the hypnotic effect and possible mechanism of tenuifolin in freely moving mice...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27776396/venous-thromboembolism-following-dantrolene-treatment-for-neuroleptic-malignant-syndrome
#15
Po-Hao Chen, Hsien-Yuan Lane, Chieh-Hsin Lin
Neuroleptic malignant syndrome (NMS) is one of the most severe iatrogenic emergencies in clinical service. The symptoms including sudden consciousness change, critical temperature elevation and electrolytes imbalance followed by mutli-organ system failure were common in NMS. In addition to aggressive interventions with intravenous fluid resuscitation and antipyretics, several antidotes have been suggested to prevent further progression of the muscle damage. Dantrolene has been reported to be one of the most effective treatments for NMS...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27413479/tapentadol-can-it-kill-two-birds-with-one-stone-without-breaking-windows
#16
REVIEW
Eun Jung Chang, Eun Ji Choi, Kyung Hoon Kim
Tapentadol is a novel oral analgesic with a dual mode of action as an agonist of the µ-opioid receptor (MOR), and as a norepinephrine reuptake inhibitor (NRI) all in a single molecule. Immediate release (IR) tapentadol shows its analgesic effect quickly, at around 30 minutes. Its MOR agonistic action produces acute nociceptive pain relief; its role as an NRI brings about chronic neuropathic pain relief. Absorption is rapid, with a mean maximal serum concentration at 1.25-1.5 h after oral intake. It is present primarily in the form of conjugated metabolites after glucuronidation, and excretes rapidly and completely via the kidneys...
July 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27212577/-pathophysiology-of-aggressive-behavior-evaluation-and-management-of-pathological-aggression
#17
E Pompili, C Carlone, C Silvestrini, G Nicolò
This work aims to define the aggression in all its forms, with notes on management and rapid tranquilization. The pathological aggression is described as a non-homogeneous phenomenon, it is variable in according to social, psychological and biological agents. The distinction of violence between affective aggression and predatory aggression can be functional to the prediction of outcome of any treatment. In general, a pattern of predatory violence tend to match with patients unresponsive and not compliant to treatment, a low probability to predict future violence and, therefore, a difficulty in managing risk...
March 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27198074/-postictal-psychoses-clinical-and-neurobiological-findings
#18
REVIEW
B de Toffol, K Kanemoto
Psychosis in epilepsy can be categorized in relation to seizures in two main categories: interictal psychosis and postictal psychosis. Postictal psychosis (PIP) is a specific syndrome in relation to seizure activity: a clear temporal relation exists between the psychotic state of sudden onset and a precipitating bout of complex partial or generalized seizures. However, this very specific syndrome is not included as such within the DSM-5, and PIP belongs to the category "Psychotic disorder due to another medical condition"...
October 2016: L'Encéphale
https://www.readbyqxmd.com/read/27037508/depressant-effects-of-salvia-divinorum-involve-disruption-of-physiological-sleep
#19
María Eva González-Trujano, Fernando Brindis, Edith López-Ruiz, Ignacio Ramírez-Salado, Adrián Martínez, Francisco Pellicer
Although Salvia divinorum is traditionally known as a 'mind-altering' or psychoactive herb used, among others things, as a tranquilizer, this property has not been validated with regard to its efficacy and safety. The objective of this study is to provide evidence for the sedative effects of S. divinorum and discriminate the nature of the responsible constituents by examining different experimental models. A battery of tests, including the open-field, hole-board, exploration cylinder, plus-maze and sodium pentobarbital-induced hypnosis potentiation, were used in mice after administration of non-polar, medium polar and/or polar extracts of the plant (10, 30 and 100 mg/kg)...
July 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26552127/-a-case-of-dengue-fever-and-subsequent-long-lasting-depression-accompanied-by-alopecia-in-a-japanese-traveler-returning-from-bali-indonesia
#20
Akihiro Hitani, Waka Yamaya, Masako To, Ichino Kano, Natsue Honda-Hosono, Tomohiko Takasaki, Kosuke Haruki
Recovery from dengue fever is generally rapid and uneventful. However, recuperation is often prolonged and may be accompanied by noticeable depression. We present herein on a traveler to Indonesia who developed long-lasting depression after the classic symptoms of dengue fever such as fever, arthralgia, and macropapular rash had resolved. A previously healthy 42-year old japanese woman presented to the Travel Clinic of Seirei Yokohama Hospital with complaints of 4 days of fever, joint aches, bone pain, and a macropapular rash on her torso...
March 2015: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
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