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Anindita Das, David Durrant, Clint Mitchell, Paul Dent, Surinder K Batra, Rakesh C Kukreja
We previously reported that Sildenafil enhances apoptosis and antitumor efficacy of doxorubicin (DOX) while attenuating its cardiotoxic effect in prostate cancer. In the present study, we investigated the mechanism by which sildenafil sensitizes DOX in killing of prostate cancer (PCa) cells, DU145. The death receptor Fas (APO-1 or CD95) induces apoptosis in many carcinoma cells, which is negatively regulated by anti-apoptotic molecules such as FLIP (Fas-associated death domain (FADD) interleukin-1-converting enzyme (FLICE)-like inhibitory protein)...
January 26, 2016: Oncotarget
Shintaro Izumi, Ken Yamashita, Masanao Nakano, Shusuke Yoshimoto, Tomoki Nakagawa, Yozaburo Nakai, Hiroshi Kawaguchi, Hiromitsu Kimura, Kyoji Marumoto, Takaaki Fuchikami, Yoshikazu Fujimori, Hiroshi Nakajima, Toshikazu Shiga, Masahiko Yoshimoto
This paper describes an electrocardiograph (ECG) monitoring SoC using a non-volatile MCU (NVMCU) and a noise-tolerant instantaneous heartbeat detector. The novelty of this work is the combination of the non-volatile MCU for normally off computing and a noise-tolerant-QRS (heartbeat) detector to achieve both low-power and noise tolerance. To minimize the stand-by current of MCU, a non-volatile flip-flop and a 6T-4C NVRAM are used. Proposed plate-line charge-share and bit-line non-precharge techniques also contribute to mitigate the active power overhead of 6T-4C NVRAM...
October 2015: IEEE Transactions on Biomedical Circuits and Systems
Misung Han, Viola Rieke, Serena J Scott, Eugene Ozhinsky, Vasant A Salgaonkar, Peter D Jones, Peder E Z Larson, Chris J Diederich, Roland Krug
PURPOSE: To demonstrate the feasibility of using ultrashort echo-time MRI to quantify T1 changes in cortical bone due to heating. METHODS: Variable flip-angle T1 mapping combined with 3D ultrashort echo-time imaging was used to measure T1 in cortical bone. A calibration experiment was performed to detect T1 changes with temperature in ex vivo cortical bone samples from a bovine femur. Ultrasound heating experiments were performed using an interstitial applicator in ex vivo bovine femur specimens, and heat-induced T1 changes were quantified...
December 2015: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Valentin G Kemper, Federico De Martino, Essa Yacoub, Rainer Goebel
PURPOSE: To evaluate the use of variable flip angle refocusing pulse trains in single-shot three-dimensional gradient and spin-echo (3D-GRASE) to reduce blurring and increase the spatial coverage for high spatial resolution T2 -weighted functional MRI at 7 Tesla. METHODS: Variable flip angle refocusing schemes in 3D-GRASE were calculated based on extended phase graph theory. The blurring along the slice (partition) direction was evaluated in simulations, as well as phantom and in vivo experiments...
September 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Boris Podobnik, Tomislav Lipic, Davor Horvatic, Antonio Majdandzic, Steven R Bishop, H Eugene Stanley
Estimating the critical points at which complex systems abruptly flip from one state to another is one of the remaining challenges in network science. Due to lack of knowledge about the underlying stochastic processes controlling critical transitions, it is widely considered difficult to determine the location of critical points for real-world networks, and it is even more difficult to predict the time at which these potentially catastrophic failures occur. We analyse a class of decaying dynamic networks experiencing persistent failures in which the magnitude of the overall failure is quantified by the probability that a potentially permanent internal failure will occur...
2015: Scientific Reports
Julia Khanova, Mary T Roth, Jo Ellen Rodgers, Jacqueline E McLaughlin
CONTEXT: The flipped classroom approach has garnered significant attention in health professions education, which has resulted in calls for curriculum-wide implementations of the model. However, research to support the development of evidence-based guidelines for large-scale flipped classroom implementations is lacking. OBJECTIVES: This study was designed to examine how students experience the flipped classroom model of learning in multiple courses within a single curriculum, as well as to identify specific elements of flipped learning that students perceive as beneficial or challenging...
October 2015: Medical Education
Xiuying Jia, Dandan Wang, Nana Gao, Hui Cao, Hangjun Zhang
Atrazine (ATR) is extensively used worldwide as an herbicide, with a global ecological influence. The widespread distribution of herbicides may be one of the possible reasons for the decline in the global amphibian population. The acute toxicity and potential toxicological mechanisms of ATR on the immune system of frogs are not well-understood. In this study, Pelophylax nigromaculata was used as an experimental carrier and exposed to 0, 1, 10, 100, and 1000 μg/L ATR solutions for 14 days, resulting in a significant decrease in the viability of their lymphocytes...
October 19, 2015: Chemical Research in Toxicology
Catherine K McKenzie, Inmaculada Sanchez-Romero, Harald Janovjak
Nature has incorporated small photochromic molecules, colloquially termed 'photoswitches', in photoreceptor proteins to sense optical cues in phototaxis and vision. While Nature's ability to employ light-responsive functionalities has long been recognized, it was not until recently that scientists designed, synthesized and applied synthetic photochromes to manipulate many of which open rapidly and locally in their native cell types, biological processes with the temporal and spatial resolution of light. Ion channels in particular have come to the forefront of proteins that can be put under the designer control of synthetic photochromes...
2015: Advances in Experimental Medicine and Biology
Maria F Dal Martello, Lisa M DeBruine, Laurence T Maloney
Typical judgments involving faces are disrupted by inversion, with the Thatcher illusion serving as a compelling example. In two experiments, we examined how inversion affects allocentric kin recognition-the ability to judge the degree of genetic relatedness of others. In the first experiment, participants judged whether pairs of photographs of children portrayed siblings or unrelated children. Half of the pairs were siblings, half were unrelated. In three experimental conditions, photographs were viewed in upright orientation, flipped around a horizontal axis, or rotated 180°...
2015: Journal of Vision
Yu-Dong Yang, Chuan-Cai Fan, Brett M Rambo, Han-Yuan Gong, Li-Jin Xu, Jun-Feng Xiang, Jonathan L Sessler
A set of environmentally responsive metal-organic [3]rotaxanes is described. These mechanically interlocked macromolecules may be prepared in quantitative yield via a one-pot procedure involving treatment of a flexible tetracationic macrocycle, known as the Texas-sized molecular box, with tri-1,3,5-benzenetricarboxylate anion and silver cations (Ag(+)). The use of this three-component mixture gives rise to a metal-organic [3]rotaxane via a self-assembly process that occurs under ambient conditions in DMSO-d6 solution...
October 14, 2015: Journal of the American Chemical Society
Jing Wang, Tiansheng Xia, Liling Xu, Taotao Ru, Ce Mo, Ting Ting Wang, Lei Mo
This study tested whether the presence of an attractive face would influence individuals' honesty. In 2 experiments, 225 participants were asked to predict the outcome of computerised coin-flips and to self-report the accuracy of their predictions. Self-reports were made in the presence of a facial photo of a female who had been rated before the experiment as high attractive, middle attractive or low attractive by other volunteers. Participants were rewarded based on their self-reported (not actual) accuracy...
September 17, 2015: International Journal of Psychology: Journal International de Psychologie
H A Davies, M M Phelan, J Madine
Thirty-one proteins are known to form extracellular fibrillar amyloid in humans. Molecular information about many of these proteins in their monomeric, intermediate or fibrillar form and how they aggregate and interact to form the insoluble fibrils is sparse. This is because amyloid proteins are notoriously difficult to study in their soluble forms, due to their inherent propensity to aggregate. Using recent developments in fast NMR techniques, band-selective excitation short transient and band-selective optimized flip-angle short-transient heteronuclear multiple quantum coherence we have been able to assign a 5 kDa full-length amyloidogenic protein called medin...
April 2016: Biomolecular NMR Assignments
Zengyi Ma, Wenqiang He, Yao Zhao, Jie Yuan, Qilin Zhang, Yue Wu, Hong Chen, Zhenwei Yao, Shiqi Li, Yongfei Wang
INTRODUCTION: It is a common view that consistency and blood supply of pituitary adenoma (PA) can influence the surgical effect. The aim of this study was to determine whether MRI signal intensity (SI) was correlated to the consistency or blood supply of pituitary macroadenoma. METHODS: Forty eight pituitary macroadenoma patients were underwent preoperative MRI, including precontrast and contrast-enhanced (CE) T1-spin echo (T1-SE) imaging, CE-sampling perfection with application-optimized contrasts by using different flip angle evolutions (SPACE) imaging, and perfusion-weighted imaging (PWI)...
January 2016: Neuroradiology
Arjan J A Beukman, Fanming Qu, Ken W West, Loren N Pfeiffer, Leo P Kouwenhoven
Electrostatic gating is essential for defining and control of semiconducting devices. However, nanofabrication processes required for depositing gates inevitably degrade the pristine quality of the material of interest. Examples of materials that suffer from such degradation include ultrahigh mobility GaAs/AlGaAs two-dimensional electron gases (2DEGs), graphene, topological insulators, and nanowires. To preserve the pristine material properties, we have developed a flip-chip setup where gates are separated from the material by a vacuum, which allows nanoscale electrostatic gating of the material without exposing it to invasive nanoprocessing...
October 14, 2015: Nano Letters
Maria D Sallee, Jessica L Feldman
No abstract text is available yet for this article.
2015: Cell Cycle
Andrew DeHennis, Stefan Getzlaff, David Grice, Marko Mailand
This paper presents an integrated circuit (IC) that merges integrated optical and temperature transducers, optical interface circuitry, and a near-field communication (NFC)-enabled digital, wireless readout for a fully passive implantable sensor platform to measure glucose in people with diabetes. A flip-chip mounted LED and monolithically integrated photodiodes serve as the transduction front-end to enable fluorescence readout. A wide-range programmable transimpedance amplifier adapts the sensor signals to the input of an 11-bit analog-to-digital converter digitizing the measurements...
January 2016: IEEE Journal of Biomedical and Health Informatics
Scott Barry Kaufman, Angela L Duckworth
The field of psychology has done a remarkable job discovering the ways people differ from one another in their abilities and talents, but has long neglected the diverse ways people can unleash those capacities. There is no plausible mechanism by which our genes directly encode skills like how to dribble a basketball, play the violin, or solve an algebraic equation. We are not born knowing how to write a sonnet or flip an omelet. On the contrary, all human expertise-even at the far-right tail of the distribution-depends on experience and training...
September 10, 2015: Wiley Interdisciplinary Reviews. Cognitive Science
A A Yaroslavov, A V Sybachin, O V Zaborova, A B Zezin, Y Talmon, M Ballauff, F M Menger
Small unilamellar liposomes, 40-60 nm in diameter, composed of anionic diphosphatidylglycerol (cardiolipin, CL(2-)) or phosphatidylcerine (PS(1-)) and zwitter-ionic egg yolk lecithin (EL) or dipalmitoylphosphatidylcholine (DPPC), electrostatically complex with polystyrene microspheres, ca. 100 nm in diameter, grafted by polycationic chains ("spherical polycationic brushes", SPBs). Polymer/liposome binding studies were carried out using electrophoretic mobility (EPM), dynamic light scattering (DLS), fluorescence, conductometry, differential scanning calorimetry (DSC), and cryogenic transmission electron microscopy (cryo-TEM) as the main analytical tools...
December 2015: Advances in Colloid and Interface Science
Robert W Stobbe, Christian Beaulieu
Sodium MRI is particularly interesting given the key role that sodium ions play in cellular metabolism. To measure concentration, images must be free from contrast unrelated to sodium density. However, spin 3/2 NMR is complicated by more than rapid biexponential signal decay. Residual quadrupole interactions (described by frequency ωQ) can reduce Mxy development during RF excitation. Three experiments, each performed on the same four healthy volunteers, demonstrate that residual quadrupole interactions are of concern in quantitative sodium imaging of the brain...
February 2016: NMR in Biomedicine
Amanda K Meier, Marin Iliev, Jeff A Squier, Charles G Durfee
We demonstrate a spectral interferometric method to characterize lateral and angular spatial chirp to optimize intensity localization in spatio-temporally focused ultrafast beams. Interference between two spatially sheared beams in an interferometer will lead to straight fringes if the wavefronts are curved. To produce reference fringes, we delay one arm relative to another in order to measure fringe rotation in the spatially resolved spectral interferogram. With Fourier analysis, we can obtain frequency-resolved divergence...
September 1, 2015: Optics Letters
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