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Vitamin D skin

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https://www.readbyqxmd.com/read/28809989/a-comparative-study-to-evaluate-epidermal-barrier-integrity-of-psoriasis-patients-treated-with-calcipotriene-betamethasone-topical-suspension-versus-betamethasone-dipropionate-0-05-lotion
#1
Peter W Hashim, John K Nia, David Terrano, Gary Goldenberg, Leon H Kircik
<p>BACKGROUND: Topical corticosteroids are known to impair the epidermal barrier, even after short-term use, whereas topical vitamin D analogues can have a reparative effect. Combination products using corticosteroids and vitamin D analogues have gained popularity in recent years and may provide a means to minimize skin atrophy in patients treated with topical corticosteroids.</p> <p>OBJECTIVE: To compare epidermal barrier function and cutaneous atrophy after 4 weeks of calcipotriene 0.005% and betamethasone dipropionate 0...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28807865/novel-compound-heterozygous-mutations-identified-by-whole-exome-sequencing-in-a-japanese-patient-with-geroderma-osteodysplastica
#2
Ryojun Takeda, Masaki Takagi, Hiroyuki Shinohara, Hiroshi Futagawa, Satoshi Narumi, Tomonobu Hasegawa, Gen Nishimura, Hiroshi Yoshihashi
Geroderma osteodysplastica (GO) is a subtype of cutis laxa syndrome characterized by congenital wrinkly skin, a prematurely aged face, extremely short stature, and osteoporosis leading to recurrent fractures. GO exhibits an autosomal recessive inheritance pattern and is caused by loss-of-function mutations in GORAB, which encodes a protein important for Golgi-related transport. Using whole exome sequencing, we identified novel compound heterozygous nonsense mutations in the GORAB in a GO patient. The patient was a 14-year-old Japanese boy...
August 11, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28793001/hypovitaminosis-d-in-patients-undergoing-kidney-transplant-the-importance-of-sunlight-exposure
#3
Cristiane F Vilarta, Marianna D Unger, Luciene M Dos Reis, Wagner V Dominguez, Elias David-Neto, Rosa M Moysés, Silvia Titan, Melani R Custodio, Mariel J Hernandez, Vanda Jorgetti
OBJECTIVES: Recent studies have shown a high prevalence of hypovitaminosis D, defined as a serum 25-hydroxyvitamin D level less than 30 ng/ml, in both healthy populations and patients with chronic kidney disease. Patients undergoing kidney transplant are at an increased risk of skin cancer and are advised to avoid sunlight exposure. Therefore, these patients might share two major risk factors for hypovitaminosis D: chronic kidney disease and low sunlight exposure. This paper describes the prevalence and clinical characteristics of hypovitaminosis D among patients undergoing kidney transplant...
July 2017: Clinics
https://www.readbyqxmd.com/read/28780880/-vitamin-d-metabolism-and-osteoporosis-in-systemic-sclerosis
#4
Szilvia Szamosi, Ágnes Horváth, Zoltán Szekanecz, Gabriella Szűcs
In the past few years more and more data have become available on the important role of vitamin D in immunological processes and inflammation. The role of vitamin D deficiency in the pathogenesis as well as in disease progression of different autoimmune and inflammatory conditions is suspected. Vitamin D deficiency is prevalent in several autoimmune diseases, including systemic sclerosis. Hypovitaminosis has been found to be associated with low bone mineral density and higher prevalence of osteoporosis in this group of patients...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28774595/interleukin-36%C3%AE-induced-by-the-tlr3-slug-vdr-axis-promotes-wound-healing-via-reg3a
#5
Ziwei Jiang, Yuanqi Liu, Changwei Li, Leilei Chang, Wang Wang, Zhenhua Wang, Xiaoguang Gao, Bernhard Ryffel, Yelin Wu, Yuping Lai
Interleukin-36 (IL-36) family members are highly expressed in hyperproliferative keratinocytes and play an important role in the pathogenesis of skin diseases such as psoriasis. However, whether and how IL-36 cytokines are induced to promote wound healing remains unknown. Here we demonstrated that skin injury increased the expression of IL-36γ to promote wound healing. Mechanistically, the expression of IL-36γ was induced by RNAs from damaged cells via the activation of Toll-like receptor 3 (TLR3) and TIR-domain-containing adapter-inducing interferon-β (TRIF) followed by the induction of a zinc finger protein SLUG to abrogate the inhibitory effect of vitamin D receptor (VDR) on the promoter of IL-36γ gene...
July 31, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28760659/no-causal-association-between-25-hydroxyvitamin-d-and-features-of-skin-aging-evidence-from-a-bidirectional-mendelian-randomization-study
#6
Raymond Noordam, Merel A Hamer, Luba M Pardo, Tamara van der Nat, Jessica C Kiefte-de Jong, Manfred Kayser, P Eline Slagboom, André Uitterlinden, M Carola Zillikens, Marian Beekman, Tamar Nijsten, Diana van Heemst, David A Gunn
Data from in-vitro experiments suggest vitamin D reduces the rate of skin aging whereas population studies suggest the opposite, most likely due to confounding by UV-exposure. We investigated whether there are causal associations between 25-hydroxyvitamin D concentrations and features of skin aging in a bidirectional Mendelian Randomization Study. In the Rotterdam Study (N=3,831; 58.2% women, median age 66.5 years) and Leiden Longevity Study (N=661; 50.5% women, median age 63.1 years), facial skin aging features (perceived age, wrinkling, pigmented spots) were assessed either manually or digitally...
July 28, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28757230/vitamin-d-high-sensitivity-c-reactive-protein-and-airway-hyperresponsiveness-in-infants-with-recurrent-respiratory-symptoms
#7
Anette M Määttä, Anne Kotaniemi-Syrjänen, Kristiina Malmström, L Pekka Malmberg, Jouko Sundvall, Anna S Pelkonen, Mika J Mäkelä
BACKGROUND: Vitamin D insufficiency might be associated with biased T-cell responses resulting in inflammatory conditions such as atopy and asthma. Little is known about the role of vitamin D in low-grade systemic inflammation and airway hyperresponsiveness (AHR) in young children. OBJECTIVE: To evaluate whether vitamin D insufficiency and increased serum high-sensitivity C-reactive protein (hs-CRP) are linked to AHR in symptomatic infants. METHODS: Seventy-nine infants with recurrent or persistent lower respiratory tract symptoms underwent comprehensive lung function testing and a bronchial methacholine challenge test...
July 28, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28756294/vitamin-d-cod-liver-oil-sunshine-and-phototherapy-safe-effective-and-forgotten-tools-for-treating-and-curing-tuberculosis-infections-a-comprehensive-review
#8
REVIEW
Patrick J McCullough, Douglas S Lehrer
Tuberculosis remains an epidemic throughout the world, with over 2 billion people, or more than one third of the world's population, infected with TB. In 2015, there were an estimated 10.4 million new cases of tuberculosis, and 1.8 million deaths, making TB one of the top ten causes of death worldwide. Approximately 95% of new TB cases occur in developing countries, where the costs of treatment force many patients and their families into poverty. The United Nations and the World Health Organization are working to end this global epidemic...
July 26, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28755031/interspecies-differences-in-plasma-concentrations-of-25-hydroxyvitamin-d3-and-dermal-vitamin-d-synthesis-of-kiwi-apteryx-mantelli-tuatara-sphenodon-punctatus-and-new-zealand-sea-lions-phocarctos-hookeri
#9
Madhumita S Kale, Keren E Dittmer, Wendi D Roe, Brett D Gartrell
Vitamin D plays a central role in calcium homeostasis of most vertebrates, and is obtained in different species through diet, dermal synthesis, or a combination of both. The aim of this study was to determine the predominant routes of Vitamin D synthesis in three disparate species, brown kiwi (Apteryx mantelli), tuatara (Sphenodon punctatus), and New Zealand sea lions (Phocarctos hookeri). We surveyed plasma concentrations of 25-hydroxyvitamin D2 and D3, analysed environmental conditions and life history factors, and determined the ability of skin samples to synthesise Vitamin D3 on exposure to ultraviolet-B radiation...
July 28, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28745244/-large-part-of-the-hague-children-taking-too-little-vitamin-d
#10
I M van der Meer, S E van der Harst, M M van Plateringen, J A de Wilde
OBJECTITVE: To investigate the extent to which 0-15-year-old children in The Hague are complying with Dutch Health Council vitamin D supplementation advice, and whether there are differences between ethnic groups. DESIGN: Cross-sectional study. METHOD: From November 2014 up to and including October 2015, The Hague organisations for youth health care (YHC) have recorded intake of vitamin D supplementation during standard consultations. YHC 0-4 recorded whether vitamin D supplementation intake was sufficient...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28737861/effects-of-25-hydroxy-vitamin-d-levels-on-the-severity-and-asthma-control-in-school-age-asthma-patients
#11
Merve Havan, Cem H Razi, Ayse D Bulus, Ali O Köksal, Nesibe Andıran
BACKGROUND: The objective was to determine vitamin D levels in patients between the ages 6 and 18 years, followed for asthma, and the relation between vitamin D levels and asthma control and severity. MATERIALS AND METHODS: Patients with asthma and healthy volunteers between the ages 6 and 18 years were enrolled into the study as patient and control groups, respectively. Patient demographic information and clinical findings were recorded; a respiratory function test was performed...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28724883/calcium-prepartions-do-not-inhibit-allergic-reactions-a-randomized-controlled-trial
#12
Klaudia Matysiak, Michał Matuszewski, Wojciech Feleszko
INTRODUCTION    Massive consumption of dietary supplements, including vitamins and minerals, has recently became a serious public issue in Europe. When ingested, they may negatively affect pharmacological activity of various medications, including anti-allergic drugs. Calcium preparations are well-known and commonly used in some European countries as a popular remedy for allergy-related skin reactions, such as itching, erythema and wheals, as well as insect bites. However, their action has not been reliably proven yet...
June 27, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28718005/sunscreens-block-cutaneous-vitamin-d-production-with-only-a-minimal-effect-on-circulating-25-hydroxyvitamin-d
#13
Florence Libon, Justine Courtois, Caroline Le Goff, Pierre Lukas, Neus Fabregat-Cabello, Laurence Seidel, Etienne Cavalier, Arjen F Nikkels
A 50+ SPF sunscreen decreased significantly cutaneous vitamin D production following a single narrow-band (nb)UVB exposure, independently from the body surface area exposed. In contrast, the circulating 25(OH)D3 levels were only minimally affected. It is probable that another endogenous source of precursors is selected when skin-originated precursors are lacking. PURPOSE: Sunscreen use, highly advocated for preventing cutaneous carcinogenesis, is potentially leading to an aggravation of vitamin D deficiency with its consequences on bone health...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28711461/prevalence-of-comorbidities-in-rheumatoid-arthritis-and-evaluation-of-their-monitoring-in-clinical-practice-the-spanish-cohort-of-the-comora-study
#14
Alejandro Balsa, Leticia Lojo-Oliveira, Mercedes Alperi-López, María García-Manrique, Carmen Ordóñez-Cañizares, Lorena Pérez, Virginia Ruiz-Esquide, Alfonso Corrales, Javier Narváez, José Rey-Rey, Carlos Rodríguez-Lozano, Soledad Ojeda, Santiago Muñoz-Fernández, Joan M Nolla, José García-Torrón, Fernando Gamero, Rosario García-Vicuña, Blanca Hernández-Cruz, José Campos, José Rosas, José Francisco García-Llorente, Antonio Gómez-Centeno, Rafael Cáliz, Raimon Sanmartí, Alberto Bermúdez, Lydia Abasolo-Alcázar, Antonio Fernández-Nebro, Luis Rodríguez-Rodríguez, Carlos Marras, Miguel Ángel González-Gay, Ihsane Hmamouchi, Emilio Martín-Mola
OBJECTIVES: To describe the prevalence of comorbidities in patients with RA in Spain and discuss their management and implications using data from the Spanish cohort of the multinational study on COMOrbidities in Rheumatoid Arthritis (COMORA). METHODS: This is a national sub-analysis of the COMORA study. We studied the demographics and disease characteristics of 200 adults patients diagnosed with RA (1987 ACR), and routine practices for screening and preventing the following selected comorbidities: cardiovascular, infections, cancer, gastrointestinal, pulmonary, osteoporosis and depression...
July 12, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28706201/genotypic-variability-based-association-identifies-novel-non-additive-loci-dhcr7-and-irf4-in-sero-negative-rheumatoid-arthritis
#15
Wen-Hua Wei, Sebastien Viatte, Tony R Merriman, Anne Barton, Jane Worthington
Sero-negative rheumatoid arthritis (RA) is a highly heterogeneous disorder with only a few additive loci identified to date. We report a genotypic variability-based genome-wide association study (vGWAS) of six cohorts of sero-negative RA recruited in Europe and the US that were genotyped with the Immunochip. A two-stage approach was used: (1) a mixed model to partition dichotomous phenotypes into an additive component and non-additive residuals on the liability scale and (2) the Levene's test to assess equality of the residual variances across genotype groups...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676457/on-the-role-of-classical-and-novel-forms-of-vitamin-d-in-melanoma-progression-and-management
#16
REVIEW
Andrzej T Slominski, Anna A Brozyna, Cezary Skobowiat, Michal A Zmijewski, Tae-Kang Kim, Zorica Janjetovic, Allen S Oak, Wojciech Jozwicki, Anton M Jetten, Rebecca S Mason, Craig Elmets, We Li, Robert M Hoffman, Robert C Tuckey
Melanoma represents a significant clinical problem affecting a large segment of the population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is an important etiological factor in malignant transformation of melanocytes and melanoma development. UVB, while being a full carcinogen in melanomagenesis, is also necessary for the cutaneous production of vitamin D3 (D3). Calcitriol (1,25(OH)2D3) and novel CYP11A1-derived hydroxyderivatives of D3 show anti-melanoma activities and protective properties against damage induced by UVB...
July 1, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28672783/vitamin-d-and-infectious-diseases-simple-bystander-or-contributing-factor
#17
REVIEW
Pedro Henrique França Gois, Daniela Ferreira, Simon Olenski, Antonio Carlos Seguro
Vitamin D (VD) is a fat-soluble steroid essential for life in higher animals. It is technically a pro-hormone present in few food types and produced endogenously in the skin by a photochemical reaction. In recent decades, several studies have suggested that VD contributes to diverse processes extending far beyond mineral homeostasis. The machinery for VD production and its receptor have been reported in multiple tissues, where they have a pivotal role in modulating the immune system. Similarly, vitamin D deficiency (VDD) has been in the spotlight as a major global public healthcare burden...
June 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28670250/the-relationship-between-severity-of-disease-and-vitamin-d-levels-in-children-with-atopic-dermatitis
#18
Ozlem Su, Anıl Gülsel Bahalı, Ayşegül Doğan Demir, Dilek Bıyık Ozkaya, Selçuk Uzuner, Didem Dizman, Nahide Onsun
INTRODUCTION: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. AIM: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. MATERIAL AND METHODS: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28662556/effect-of-latitude-on-vitamin-d-levels
#19
Patrick F Leary, Ina Zamfirova, Johnathan Au, Ward H McCracken
Context: Vitamin D levels have been linked to bone health and to numerous diseases; however, an element that lacks substantial direct data and limits the evidence basis regarding whom to screen for vitamin D deficiency is the effect of latitude on vitamin D levels. Objectives: To determine whether latitude influences vitamin D levels and to investigate the influence of other factors that may affect vitamin D levels, including sex, race, skin type, and body mass index...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28662432/cathelicidin-augments-vdr-dependent-anti-leishmanial-immune-response-in-indian-post-kala-azar-dermal-leishmaniasis
#20
Sushmita Das, Abul Hasan Sardar, Kumar Abhishek, Ajay Kumar, Vidya Nand Rabidas, Pradeep Das
OBJECTIVES: Indian Post kala-azar dermal leishmaniasis (PKDL) is the cutaneous aftermath of visceral leishmaniasis (VL) caused by L. donovani. Vitamin D-regulated cationic antimicrobial peptide cathelicidin (hCAP-18/LL-37) has microbicidal and immunomodulatory role against cutaneous infections, but its role in PKDL remains elusive. METHODS: Skin snips and blood-derived monocytes of PKDL patients (n=46), before (BT) and after (AT) chemotherapy, were used for this study...
June 26, 2017: International Immunopharmacology
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