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Vitamin D skin

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https://www.readbyqxmd.com/read/29782293/mycosis-fungoides-and-vitamin-d-status-analyses-of-serum-25-hydroxyvitamin-d-levels-and-single-nucleotide-polymorphisms-in-the-vitamin-d-receptor-gene
#1
Pinar Incel Uysal, Nuran Alli, Yildiz Hayran, Tuba Candar
Various types of cancer, including melanoma and non-melanoma skin cancer, are associated with vitamin D receptor (VDR) polymorphisms. However, few studies have addressed VDR polymorphisms in patients with mycosis fungoides (MF), and previous studies have reported conflicting results. Aim of this case-control study was to assess the correlation between VDR single nucleotide polymorphisms (SNPs) Cdx2, Fok1, Apa1, Bsm1, and Taq1 and MF. Venous blood samples were collected from 41 patients with MF and 59 age- and sex-matched healthy controls...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29775091/chronotherapy-of-maxacalcitol-on-skin-inflammation-induced-by-topical-12-o-tetradecanoylphorbol-13-acetate-in-mice
#2
Daisuke Yoshioka, Hitoshi Ando, Kentaro Ushijima, Masafumi Kumazaki, Akio Fujimura
In general, chronotherapy is desirable for a more effective and/or safe dosage regimen. In this study, a daily rhythm of skin vitamin D receptor (VDR) and chronotherapeutic profiles of maxacalcitol, a vitamin D analogue, were evaluated using mice with skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This study showed that skin nuclear VDR expression in TPA-treated mice has a daily rhythm with the peak at the middle of active period. The effects of maxacalcitol were greater after dosing during early to middle of active period than those after dosing during early to middle of inactive period...
May 18, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29764626/25-hydroxvitamin-d-concentrations-are-not-lower-in-children-with-bronchial-asthma-atopic-dermatitis-obesity-or-attention-deficient-hyperactivity-disorder-than-in-healthy-children
#3
Thomas Reinehr, Christian Langrock, Eckard Hamelmann, Thomas Lücke, Cordula Koerner-Rettberg, Martin Holtmann, Tanja Legenbauer, Stephanie Gest, Mirjam Frank, Börge Schmidt, Katharina Radkowski, Karl-Heinz Jöckel
Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), and obesity because the affected tissues express vitD receptors. Furthermore, obesity, AD, and BA are regarded as inflammatory diseases...
April 2018: Nutrition Research
https://www.readbyqxmd.com/read/29741192/seasonal-variation-in-vitamin-d-status-among-frail-older-hospitalized-patients
#4
M Pourhassan, R Wirth
BACKGROUND AND OBJECTIVES: Seasonal variation in 25-hydroxyvitamin D [25(OH)D] levels is the result of sunlight dependent skin synthesis of vitamin D. However, its presence is not studied in frail older hospitalized patients. We sought to investigate whether seasonal variation in 25(OH)D levels is evident among these patients. DESIGN AND SETTING: This study investigated older participants who were consecutively admitted between February 2015 and December 2016 to the geriatric acute care ward...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29730334/fractional-sunburn-threshold-uvr-doses-generate-equivalent-vitamin-d-and-dna-damage-in-skin-types-i-vi-but-with-epidermal-dna-damage-gradient-correlated-to-skin-darkness
#5
Barbara B Shih, Mark D Farrar, Marcus S Cooke, Joanne Osman, Abigail K Langton, Richard Kift, Ann R Webb, Jacqueline L Berry, Rachel E B Watson, Andy Vail, Frank R de Gruijl, Lesley E Rhodes
Public health guidance recommends limiting sun-exposure to sub-sunburn levels, but it's unknown whether these can gain vitamin D (for musculoskeletal health) whilst avoiding epidermal DNA damage (initiates skin cancer). Well-characterised healthy humans of all skin types (I-VI; lightest to darkest skin) were exposed to a low dose-series of solar simulated UVR of 20-80% their individual sunburn threshold dose (minimal erythemal dose, MED). Significant UVR dose-responses were seen for serum 25(OH)D and whole epidermal CPD, with as little as 0...
May 3, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29718444/photobiology-of-vitamins
#6
Mark Lucock, Patrice Jones, Charlotte Martin, Zoe Yates, Martin Veysey, John Furst, Emma Beckett
This review explores contemporary ideas about the relationship between light exposure and vitamin biology. Nutritional biochemistry has long recognized the relationship between vitamins A and D and light exposure, but in recent years other vitamins have also been implicated in photoresponsive biological mechanisms that influence health, well-being, and even evolutionary processes. Interactions between light and vitamins can modify genotype-phenotype relationships across the life cycle, providing a basis for interesting new explanations relevant to wide aspects of human biology...
April 28, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29710859/the-vitamin-d%C3%A2-folate-hypothesis-as-an-evolutionary-model-for-skin-pigmentation-an-update-and-integration-of-current-ideas
#7
REVIEW
Patrice Jones, Mark Lucock, Martin Veysey, Emma Beckett
Vitamin D is unique in being generated in our skin following ultraviolet radiation (UVR) exposure. Ongoing research into vitamin D must therefore always consider the influence of UVR on vitamin D processes. The close relationship between vitamin D and UVR forms the basis of the “vitamin D⁻folate hypothesis”, a popular theory for why human skin colour has evolved as an apparent adaption to UVR environments. Vitamin D and folate have disparate sensitivities to UVR; whilst vitamin D may be synthesised following UVR exposure, folate may be degraded...
April 30, 2018: Nutrients
https://www.readbyqxmd.com/read/29707883/evaluation-of-selected-skin-parameters-following-the-application-of-5-vitamin-c-concentrate
#8
Anna Jaros, Malwina Zasada, Elżbieta Budzisz, Renata Dębowska, Monika Gębczyńska-Rzepka, Helena Rotsztejn
BACKGROUND: Ascorbic acid is a substance with confirmed anti-free-radical properties. It triggers the collagen synthesis, has a depigmenting effect and seals blood vessels. All these properties have a significant effect of the skin's appearance. The characteristic traits of capillary skin include telangiectasias as well as erythema, which might consolidate in the future, along with the feeling of burning and increased skin sensitivity. OBJECTIVES: Study and evaluation of selected parameters of capillary skin after the application of 5% vitamin C concentrate throughout the period of 6 weeks with the use of instrumental tests and questionnaires...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29696236/temporal-trends-and-characteristics-of-clinical-trials-for-which-only-one-racial-or-ethnic-group-is-eligible
#9
Brian L Egleston, Omar Pedraza, Yu-Ning Wong, Candace L Griffin, Eric A Ross, J Robert Beck
Background: Increasing diversity in clinical trials may be worthwhile. We examined clinical trials that restricted eligibility to a single race or ethnicity. Methods: We reviewed 19,246 trials registered on ClinicalTrials.gov through January 2013. We mapped trial ZIP-codes to U.S. Census and American Community Survey data. The outcome was whether trials required participants to be from a single racial or ethnic group. Results: In adjusted analyses, the odds of trials restricting eligibility to a single race/ethnicity increased by 4% per year (95% CI 1...
March 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29695409/soy-phosphatidylglycerol-reduces-inflammation-in-a-contact-irritant-ear-edema-mouse-model-in-vivo
#10
Ding Xie, Vivek Choudhary, Mutsa Seremwe, John G Edwards, Angela Wang, Aaron C Emmons, Katherine A Bollag, Maribeth H Johnson, Wendy B Bollag
We have previously shown that phosphatidylglycerol (PG) regulates the function of keratinocytes, the predominant cells that comprise the epidermis, inhibiting the proliferation of rapidly dividing keratinocytes. In particular, soy PG, a PG mixture with a high proportion of polyunsaturated fatty acids, is efficacious at inhibiting these proliferating keratinocytes. Psoriasis is a skin disorder characterized by hyperproliferation of keratinocytes and inflammation. Data in the lung suggest that PG in pulmonary surfactant inhibits inflammation...
April 25, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29691848/children-sustain-high-levels-of-skin-dna-photodamage-with-a-modest-increase-of-serum-25-oh-d-3-after-a-summer-holiday-in-northern-europe
#11
J Narbutt, P A Philipsen, A Lesiak, T Sandberg Liljendahl, D Segerbäck, J Heydenreich, D Chlebna-Sokol, P Olsen, G I Harrison, A Pearson, K Baczynska, M Rogowski-Tylman, H C Wulf, A R Young
BACKGROUND: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children. OBJECTIVES: The impact of a 12-day Baltic Sea (54o N) beach holiday on serum 25-dihydroxyvitamin D (25(OH)D3 ) and CPD was assessed in 32 healthy Polish children (skin types I-IV)...
April 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29673142/meeting-vitamin-d-requirements-in-white-caucasians-at-uk-latitudes-providing-a-choice
#12
Ann R Webb, Andreas Kazantzidis, Richard C Kift, Mark D Farrar, Jack Wilkinson, Lesley E Rhodes
The body gains vitamin D through both oral intake (diet/supplementation) and synthesis in skin upon exposure to ultraviolet radiation (UVR). Sun exposure is the major source for most people even though sun exposure is complex and limited by climate and culture. We aimed to quantify the sun exposure required to meet vitamin D targets year-round and determine whether this can be safely achieved in a simply defined manner in the UK as an alternative to increasing vitamin D oral intake. Data from observation (sun exposure, diet, and vitamin D status) and UVR intervention studies performed with white Caucasian adults were combined with modeled all-weather UVR climatology...
April 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29671368/the-efficacy-of-topical-human-amniotic-membrane-mesenchymal-stem-cell-conditioned-medium-hammsc-cm-and-a-mixture-of-topical-hammsc-cm-vitamin-c-and-hammsc-cm-vitamin-e-on-chronic-plantar-ulcers-in-leprosy-a-randomized-control-trial
#13
Crs Prakoeswa, F R Natallya, D Harnindya, A Thohiroh, R N Oktaviyanti, K D Pratiwi, M A Rubianti, B Yogatri, P I Primasari, N Herwanto, M D Alinda, B H Kusumaputra, L Astari, M Y Listiawan, I Agusni, F A Rantam
BACKGROUND: Healing of chronic plantar ulcers in leprosy (CPUL) typically takes a long time due to impaired neurological function, thereby reducing the levels of growth factors and cytokines. Cytokines can be found in metabolite products from amniotic membrane stem cells. Chronic ulcers are frequently characterized by high levels of reactive oxygen species. Vitamin E (α-tocopherol) is widely used in skin lesions, owing to its antioxidant and anti-inflammatory properties. Vitamin C also has antioxidant, anti-inflammatory, and collagen synthesis properties useful in wound healing...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29666967/health-maintenance-in-inflammatory-bowel-disease
#14
REVIEW
Fazia A Mir, Sunanda V Kane
PURPOSE OF REVIEW: Patients with inflammatory bowel disease (IBD) are not receiving preventative care services at the same rate as the general population. IBD patients are at increased risk for infections, osteoporosis, and certain malignancies secondary to their disease and as they are on immunosuppressive therapy. They are a younger population and often times consider their gastroenterologist as their primary care physician. In this review, we discuss up-to-date evidence pertaining to vaccine-preventable illnesses in the immunosuppressed IBD patient, screening for bone health, cervical cancer, skin malignancies, psychological wellbeing, and smoking cessation...
April 17, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29661756/prevention-of-rickets-and-osteomalacia-in-the-uk-political-action-overdue
#15
REVIEW
Suma Uday, Wolfgang Högler
The consequences of vitamin D and dietary calcium deficiency have become a huge public health concern in the UK. The burden of disease from these deficiencies includes rickets, and hypocalcaemic seizures, dilated cardiomyopathy and mostly occult myopathy and osteomalacia. The increasing burden of the disease is intrinsically linked to ethnicity and the population demographic changes in the UK. Three facts have led to the resurfacing of the English disease: (1) the UK has no ultraviolet sunlight for at least 6 months of the year, (2) dark skin produces far less vitamin D than white skin per unit ultraviolet light exposure, and (3) non-European Union immigration over the last century...
April 16, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29642423/colour-counts-sunlight-and-skin-type-as-drivers-of-vitamin-d-deficiency-at-uk-latitudes
#16
Ann R Webb, Andreas Kazantzidis, Richard C Kift, Mark D Farrar, Jack Wilkinson, Lesley E Rhodes
Sunlight exposure, with resulting cutaneous synthesis, is a major source of vitamin D for many, while dietary intake is low in modern diets. The constitutive pigment in skin determines skin type, observed as white, brown, or black skin. The melanin pigment absorbs ultraviolet radiation (UVR) and protects underlying skin from damage caused by UVR. It also reduces the UVR available for vitamin D synthesis in the skin. It has been shown that the white-skinned population of the UK are able to meet their vitamin D needs with short, daily lunchtime exposures to sunlight...
April 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29619453/effect-of-solar-ultraviolet-radiation-exposure-on-serum-25-oh-d-concentration-a-pilot-randomised-controlled-trial
#17
Shanchita R Khan, David C Whiteman, Michael G Kimlin, Monika Janda, Michael W Clarke, Robyn M Lucas, Rachel E Neale
Sunlight generates vitamin D, but there are scant human data from randomised trials on which to base health policy advice about how much sun exposure is necessary to change 25(OH)D concentrations. The purpose of the study was to evaluate the feasibility of using solar ultraviolet (UV) radiation exposure to generate a change in 25(OH)D concentration in a randomised controlled trial (RCT). The intervention tested in this RCT was supervised exposure to one standard erythemal dose (SED; 100 J m-2) of solar UV radiation three days per week for three weeks with approximately 35% of the body surface area not covered by clothing...
April 5, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29611292/vitamin-d-deficiency-is-associated-with-ethnicity-and-knee-pain-in-a-multi-ethnic-south-east-asian-nation-results-from-malaysian-elders-longitudinal-research-melor
#18
Sumaiyah Mat, Mohamad Hasif Jaafar, Sargunan Sockalingam, Jasmin Raja, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Azlina Amir Abbas, Chee Ken Chan, Noran Naqiah Hairi, Sajaratulnisah Othman, Robert Cumming, Maw Pin Tan
AIM: To determine the association between vitamin D and knee pain among participants of the Malaysian Elders Longitudinal Research (MELoR) study. METHOD: This was a cross-sectional study from the MELoR study consisting of a representative group of 1011 community-dwelling older persons (57% female), mean age 86.5 (54-94) years; 313 were Malays, 367 Chinese and 330 Indians. Participants were asked if they had knee pain. Levels of serum 25-hydroxy cholecalciferol (25-[OH]D), an indicator of vitamin D status, were measured using routine laboratory techniques...
April 3, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29609719/the-association-between-vitamin-d-level-and-restless-legs-syndrome-a-population-based-case-control-study
#19
Siraj Wali, Samah Alsafadi, Bahaa Abaalkhail, Iman Ramadan, Badr Abulhamail, Moaiyyad Kousa, Reem Alshamrani, Hanan Faruqui, Abdulaziz Faruqui, Mohamed Alama, Mohamed Hamed
STUDY OBJECTIVES: The pathophysiology of restless legs syndrome (RLS) may be related to abnormalities in central dopamine pathways. Vitamin D may play a role in the pathophysiology of RLS by modulating the dopaminergic system. The aim of our study is to examine the possible link between RLS and vitamin D deficiency. METHODS: The total number of subjects enrolled was 201, including 78 patients with RLS based on the International RLS Study Group (IRLSSG) diagnostic criteria and 123 controls...
April 15, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29606809/a-study-on-vitamin-d-and-cathelicidin-status-in-patients-with-rosacea-serum-level-and-tissue-expression
#20
Bok Won Park, Ji Min Ha, Eun Byul Cho, Jae Kwang Jin, Eun Joo Park, Hye Rim Park, Hee Jung Kang, Sung Hoon Ko, Kwang Ho Kim, Kwang Joong Kim
Background: Rosacea is a chronic inflammatory disease characterized by centrofacial erythema. Excess cathelicidin is suggested to be important to the pathophysiology of the disease. Recently, presence of a vitamin D response element was revealed in the cathelicidin gene promoter. Objective: The aim of this study was to determine whether vitamin D and cathelicidin are associated with rosacea, both serologically and histopathologically. Methods: Subjects with rosacea and without chronic skin disorders were enrolled in the patient and control groups, respectively...
April 2018: Annals of Dermatology
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