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Vitamin D skin

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https://www.readbyqxmd.com/read/29165303/immunoreactivity-to-cyp24a1-but-not-vitamin-d-receptor-is-increased-in-mast-cells-of-keratinocyte-skin-cancers
#1
Antti Kaukinen, Hanna Siiskonen, Jukka Pelkonen, Ilkka T Harvima
In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites. To examine immunoreactivity to VDR and CYP24A1 in mast cells from normal human skin, keratinocyte skin cancers, and disorders of chronic inflammation. Frozen biopsies were collected from the non-lesional and lesional skin of patients with actinic keratosis (AK), Bowen's disease/squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and psoriasis...
November 22, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29156273/contribution-of-sun-exposure-to-the-vitamin-d-dose-received-by-various-groups-of-the-spanish-population
#2
Maria-Antonia Serrano
Although the harmful effects of excessive exposure to solar ultraviolet (UV) radiation are well known, the recommended dose of UV radiation is beneficial for the synthesis of vitamin D by the skin, in addition to being useful in the treatment of various illnesses and mental problems. Numerous studies have shown that vitamin D performs important functions in the human organism, such as absorbing calcium and phosphorous and contributing to the immune system, among others. Several studies have found that a high percentage of various groups of the Spanish population suffer from vitamin D deficiency, and since very few natural foods contain vitamin D, it was considered important to determine whether groups such as schoolchildren, outdoor workers and athletes, receive enough solar radiation to produce adequate levels of vitamin D in their daily activities...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155557/wearable-nanoplasmonic-patch-detecting-sun-uv-exposure
#3
Jessica G Barajas-Carmona, Leydi Francisco-Aldana, Eden Morales-Narváez
Sun exposure is known to yield beneficial health outcomes, including synthesis of adequate levels of vitamin D, beneficial modulation of blood pressure and is a valuable factor in mental health care. However, the increasing incidence of sun/UV exposure-related illness, such as skin cancer, is seriously concerning public health authorities as well as the scientific community. Consequently, moderate sun/UV exposure is strongly recommended. A wearable nanoplasmonic patch whose original color changes upon sun exposure due to its UV-responsive capabilities that are visually detectable has been engineered...
November 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29150278/a-hypothetical-role-for-notch-signaling-pathway-in-immunopathogenesis-of-leprosy
#4
Héctor Serrano-Coll, Liliana Acevedo-Saenz, Nora Cardona-Castro
Leprosy is a chronic infectious disease caused by Mycobacterium leprae mainly affecting skin and peripheral nerves. Leprosy has a broad range of clinical manifestations that range from mild (tuberculoid leprosy) to severe (lepromatous leprosy) forms, and are highly dependent on the host's immune response. Among the immune response elements involved in the pathogenesis of leprosy are the Toll-like receptors (TLRs), vitamin D receptor (VDR), natural killer cells (NK), and T cells. These innate and adaptive immune response elements may be related to the Notch signaling pathway, which is involved in immune cell growth, differentiation, and proliferation...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29144098/correlation-between-plasmatic-levels-of-vitamin-d-and-pasi-score-our-experience-and-mini-review-of-the-literature
#5
Carlo Mattozzi, Giovanni Paolino, Monica Salvi, Laura Macaluso, Marco Scarno', Gaetano DE Vita, Stefano Calvieri, Antonio G Richetta
BACKGROUND: Psoriasis is a common, inflammatory, chronic, relapsing skin disease. The pathogenesis is multifactorial and it is involved both innate and acquired immunity. Several studies have shown the important role of vitamin D in the pathogenesis of this disorder. In this study we have evaluated a possible correlation between vitamin D and clinical severity of psoriasis calculated with PASI score. METHODS: In this case control study we included 141 Caucasian subjects affected by moderate to severe psoriasis and 62 healthy controls...
November 16, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29143981/high-plasma-25-hydroxyvitamin-d-and-high-risk-of-non-melanoma-skin-cancer-a-mendelian-randomisation-study-of-97849-individuals
#6
U C Winsløw, B G Nordestgaard, S Afzal
BACKGROUND: High plasma 25-hydroxyvitamin D (25 (OH)D) concentration has been associated observationally with high risk of non-melanoma skin cancer, while many studies suggest that vitamin D could have a protective effect on cancer. The true association between vitamin D and risk of skin cancer remains unclear. OBJECTIVES: In this Mendelian randomisation study we tested the hypothesis that genetically high plasma 25(OH)D protects against non-melanoma skin cancer...
November 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29141054/managing-seborrheic-keratoses-evolving-strategies-for-optimizing-patient-outcomes
#7
Geraldine Cheyana Ranasinghe, Adam J Friedman
<p>The seborrheic keratosis is the most common benign skin tumor of middle-aged and elderly adults, affecting nearly 83 million individuals in the US alone. Although these are benign lesions, many patients still undergo some form of treatment. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so. The most commonly used method of removal is cryotherapy, however there are numerous other options that can be employed with varying degrees of efficacy...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29139360/vitamin-d-deficiency-in-an-alopecia-referral-clinic-during-a-3-month-period-the-need-to-pursue-systemic-screening
#8
Zuhair Siddiqui, Rashid M Rashid, Paradi Mirmirani
Alopecia is typically viewed as a localized process, and comorbidities are not usually analyzed. The authors examine the prevalence of vitamin D deficiency among patients attending an alopecia clinic during a 3-month period. The data showed that 79% of patients had vitamin D deficiency, and the average value of low vitamin D was 19.1 mg/mL in patients. Vitamin D levels have not been examined extensively in skin disorders, and it is not clear whether vitamin D levels are correlative or causative in alopecia...
2017: Skinmed
https://www.readbyqxmd.com/read/29132666/prevention-of-food-allergies
#9
REVIEW
Jennifer J Koplin, Rachel L Peters, Katrina J Allen
This review summarizes the current state of play with regard to food allergy prevention. Food allergy prevention strategies focused on promoting timely introduction of allergenic foods (predominantly peanut) into the infant diet have recently been introduced in several countries. Additional prevention strategies currently under investigation include optimizing infant vitamin D levels, modulating the gut microbiota through use of probiotics, and preventing eczema to reduce the risk of food sensitization through a damaged skin barrier...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29124697/ultraviolet-b-radiation-the-vitamin-d-connection
#10
Michael F Holick
Vitamin D is known as the sunshine vitamin. During exposure to sunlight the skin transforms 7-dehydrocholesterol into vitamin D3. Throughout evolution vitamin D3 has played a pivotal role in the evolution of vertebrates. Vitamin D is not only critically important for bone health but has a multitude of other biologic functions to help reduce chronic illnesses. This Chapter reviews how vitamin D is produced in the skin, factors that affect its production and a prospective on how to obtain vitamin D from sensible sun exposure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29115927/transcriptomic-responses-to-wounding-meta-analysis-of-gene-expression-microarray-data
#11
Piotr Andrzej Sass, Michał Dąbrowski, Agata Charzyńska, Paweł Sachadyn
BACKGROUND: A vast amount of microarray data on transcriptomic response to injury has been collected so far. We designed the analysis in order to identify the genes displaying significant changes in expression after wounding in different organisms and tissues. This meta-analysis is the first study to compare gene expression profiles in response to wounding in as different tissues as heart, liver, skin, bones, and spinal cord, and species, including rat, mouse and human. RESULTS: We collected available microarray transcriptomic profiles obtained from different tissue injury experiments and selected the genes showing a minimum twofold change in expression in response to wounding in prevailing number of experiments for each of five wound healing stages we distinguished: haemostasis & early inflammation, inflammation, early repair, late repair and remodelling...
November 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29114901/allergic-contact-dermatitis-caused-by-calcipotriol
#12
Liesbeth Gilissen, Sara Huygens, An Goossens
BACKGROUND: Calcipotriol, a synthetic vitamin D analogue, is widely used for the topical treatment of psoriasis. It often causes irritant reactions, whereas allergic contact dermatitis has less commonly been reported. OBJECTIVES: To report on 6 patients (among them an 11-year-old child) who presented with eczematous lesions complicating pre-existing dermatitis, observed in our tertiary referral patch test clinic between 2004 and 2016. METHODS: Patch tests were performed with the commercial preparation used by the patients and/or its ingredients, including calcipotriol (2 or 10 µg/ml in isopropyl alcohol), according to ESCD patch test guidelines...
November 8, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/29104377/seasonal-variation-in-vitamin-d-in-association-with-age-inflammatory-cytokines-anthropometric-parameters-and-lifestyle-factors-in-older-adults
#13
Leticia Elizondo-Montemayor, Elena C Castillo, Carlos Rodríguez-López, José R Villarreal-Calderón, Merit Gómez-Carmona, Sofia Tenorio-Martínez, Bianca Nieblas, Gerardo García-Rivas
Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40'0″N). 25(OH)D levels remained below <30 ng/mL through all seasons...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29099117/deficiencia-de-vitamina-d-en-madres-y-neonatos-mexicanos
#14
E C Ochoa-Correa, P A García-Hernández, J Z Villarreal-Pérez, C Treviño-Garza, I Rodríguez-Balderrama, L E Martínez-de Villarreal, C A Zapata-Castilleja, M E De la O-Cavazos
Objective: The purpose of this study is to establish the prevalence of vitamin D deficiency and their newborns and analyze the risk factors related to this deficiency. Methods: This is an observational, transversal, and prospective study. It included 191 puerperal women and their full-term newborns. Serum 25 hydroxyvitamin D values were analyzes by enzyme immunoassay. Results: 61% of the puerperal presented deficiency and 26% insufficiency of vitamin D...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29080365/narrow-band-uvb-effects-on-cutaneous-vitamin-d-receptor-expression-and-serum-25-hydroxyvitamin-d-in-generalized-vitiligo
#15
Hala M El-Hanbuli, Noha Mohammed Dawoud, Rania Hosny Mahmoud
Vitamin D has a role in variety of autoimmune diseases including vitiligo. Narrow band UVB (NB-UVB) treatment of vitiligo might act through its effects on vitamin D and its receptor METHODS: The present study is the first to elucidate NB-UVB effects on immunohistochemical vitamin D receptor (VDR) expression in generalized vitiligo and correlate it with serum vitamin D and repigmentation response. Using immunohistochemistry, VDR expression was estimated in skin biopsies of 30 controls and 30 vitiligo patients; from vitiligo lesion, perilesional skin at baseline and from repigmented and non responding skin after 24 NB-UVB sessions...
October 28, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29074837/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-in-the-treatment-of-psoriasis
#16
Shun Sawatsubashi
Active vitamin D and analogs exert immunomodulatory effects and potent effects on cellular differentiation and proliferation in the skin. In the last few decades, it has convincingly been shown that these analogs are effective and safe in the topical treatment of psoriasis, where they nowadays represent a standard therapy. However, the mechanism of vitamin D action in the treatment of psoriasis remains largely unknown. Here, we reviewed and discussed the recent findings of molecular action of vitamin D in psoriasis...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074824/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-and-bone-mineral-metabolism
#17
Ritsuko Masuyama
Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1α,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. The biological significance of 1α,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic β cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29074823/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-metabolism-and-its-regulation
#18
Toshimi Michigami
Vitamin D is taken up from food as D2 and D3. Vitamin D3 is also synthesized from 7-dehydrocholesterol in the skin by the exposure of ultraviolet B. The D2 and D3, which are called native vitamin D, are hydroxylated at C25 in the liver by CYP2R1 and then at C1 in the kidney by CYP27B1, to be converted to an active vitamin D metabolite, 1,25-dihydroxyvitamin D[1,25(OH)2D]. CYP24A1 converts 25-hydroxyvitamin D(25OHD)and 1,25(OH)2D to 24,25-dihydroxyvitamin D[24,25(OH)2D]and 1,24,25-trihydroxyvitamin D[1,24,25(OH)3D], respectively, to decrease the level of 1,25(OH)2D...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29064176/calciphylaxis-after-parathyroidectomy
#19
Sathish Karmegam, Anupkumar Shetty
A 60-year-old African American man with end stage renal disease on hemodialysis (HD) for the past 2.5 years developed severe hyperparathyroidism. Other past medical history included atrial fibrillation, type II diabetes mellitus, hypertension, gout, pericardial effusion needing pericardial window, deep vein thrombosis, mitral insufficiency, and cardiomyopathy with implantable cardioversion device placement. His parathyroid hormone (PTH) level peaked at 4,191 pg/mL despite being on cinacalcet, sevelamer, and paricalcitol...
October 2017: Hemodialysis International
https://www.readbyqxmd.com/read/29060367/personalized-cumulative-uv-tracking-on-mobiles-wearables
#20
S Dey, S Sahoo, H Agrawal, A Mondal, T Bhowmik, V N Tiwari
Maintaining a balanced Ultra Violet (UV) exposure level is vital for a healthy living as the excess of UV dose can lead to critical diseases such as skin cancer while the absence can cause vitamin D deficiency which has recently been linked to onset of cardiac abnormalities. Here, we propose a personalized cumulative UV dose (CUVD) estimation system for smartwatch and smartphone devices having the following novelty factors; (a) sensor orientation invariant measurement of UV exposure using a bootstrap resampling technique, (b) estimation of UV exposure using only light intensity (lux) sensor (c) optimal UV exposure dose estimation...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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