keyword
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#1
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38528743/c-reactive-protein-as-a-novel-biomarker-for-vitamin-d-deficiency-in-alopecia-areata
#2
JOURNAL ARTICLE
Ahmed Ibrahim AbdElneam, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Ahmed Kaid Alantry, Lina Mohamed Atef
BACKGROUND: Alopecia areata (AA) is an autoimmune condition characterized by sudden and unpredictable hair loss, with a lifetime incidence of 2%. AA can be divided into three categories: patchy alopecia, alopecia totalis, and alopecia universalis. It can affect a person's psychological health and overall quality of life. Elevated C-reactive protein (CRP) levels in the liver may indicate an inflammatory response in autoimmune diseases. Vitamin D, essential for immune system control and skin health, may be related to AA...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38500274/an-overview-of-contemporary-and-future-therapeutic-strategies-for-scalp-psoriasis
#3
JOURNAL ARTICLE
Bindu Soni, Riya Shivgotra, Karan Trehan, Aashveen Chhina, Muskaan Saini, Subheet Kumar Jain, Shubham Thakur
Scalp psoriasis is a common manifestation of psoriasis that significantly impacts a patient's quality of life. About 80% of cases of psoriasis involve the scalp, making it the most frequently affected area of the body. The treatment of scalp psoriasis is particularly crucial because of its hard-to-treat nature and substantial adverse impacts on overall well-being. Along with the physical symptoms of discomfort and itching, psoriasis, especially when it affects the scalp, can cause severe psychological damage...
March 15, 2024: Current Drug Targets
https://read.qxmd.com/read/38483248/effect-of-weekly-vitamin-d-supplementation-on-the-severity-of-atopic-dermatitis-and-type-2-immunity-biomarkers-in-children-a-randomized-controlled-trial
#4
JOURNAL ARTICLE
Arturo Borzutzky, Carolina Iturriaga, Guillermo Pérez-Mateluna, Francisca Cristi, Lorena Cifuentes, Sergio Silva-Valenzuela, Cristián Vera-Kellet, Carolina Cabalín, Rodrigo Hoyos-Bachiloglu, Cristian Navarrete-Dechent, María Laura Cossio, Catalina Le Roy, Carlos A Camargo
BACKGROUND: Vitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients. OBJECTIVES: To investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers. METHODS: We performed a randomized, double-blind, placebo-controlled trial...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38479895/predicting-vitamin-d-deficiency-using-optimized-random-forest-classifier
#5
JOURNAL ARTICLE
Aladeen Alloubani, Belal Abuhaija, M Almatari, Ghaith Jaradat, Baha Ihnaini
BACKGROUND: Vitamin D can be acquired from various dietary sources, but exposure to sunlight's ultraviolet rays can convert a natural compound called ergosterol present in the skin into vitamin D. AIM: The current study aimed to investigate vital parameters and use an optimized random forest (OptRF) classifier to understand better and predict the effect of environmental and nutritional factors of Vitamin D deficiency. METHODS: A predictive, cross-sectional, and correlational design was utilized in a study involving 350 male and female Tabuk citizens in Saudi Arabia...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38473753/fibroblast-growth-factor-receptor-inhibitors-decrease-proliferation-of-melanoma-cell-lines-and-their-activity-is-modulated-by-vitamin-d
#6
JOURNAL ARTICLE
Anna Piotrowska, Joanna I Nowak, Justyna M Wierzbicka, Paweł Domżalski, Monika Górska-Arcisz, Rafał Sądej, Delfina Popiel, Maciej Wieczorek, Michał A Żmijewski
Regardless of the unprecedented progress in malignant melanoma treatment strategies and clinical outcomes of patients during the last twelve years, this skin cancer remains the most lethal one. We have previously documented that vitamin D and its low-calcaemic analogues enhance the anticancer activity of drugs including a classic chemotherapeutic-dacarbazine-and an antiangiogenic VEGFRs inhibitor-cediranib. In this study, we explored the response of A375 and RPMI7951 melanoma lines to CPL304110 (CPL110), a novel selective inhibitor of fibroblast growth factor receptors (FGFRs), and compared its efficacy with that of AZD4547, the first-generation FGFRs selective inhibitor...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465786/exploring-the-impact-of-diet-and-nutrition-on-vitiligo-a-systematic-review-of-dietary-factors-and-nutritional-interventions
#7
REVIEW
Zeenat Hadi, Ravneet Kaur, Zahra Parekh, Sukul Khanna, Ahmed Bazil Bin Khalil, Haleema Qayyum Abbasi, Faiza Ashfaque, Dhruvi Shah, Vikaskumar Jitendrakumar Patel, Md Al Hasibuzzaman
BACKGROUND: Vitiligo, an autoimmune skin disorder linked to hormonal and genetic factors, results in reduced pigmentation due to a gradual decline in melanocyte activity. This systematic review delves into the role of dietary intervention and nutrition in managing vitiligo. METHODS: A comprehensive search on PubMed, Google Scholar, and European PMC identified 214 studies, with 14 meeting inclusion criteria post-screening. The selected studies primarily explored the impact of dietary supplements on disease activity...
March 11, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38465749/microneedles-a-novel-clinical-technology-for-evaluating-skin-characteristics
#8
JOURNAL ARTICLE
Seo Hyeong Kim, Ji Hye Kim, Yoon Mi Choi, Su Min Seo, Eun Young Jang, Sung Jae Lee, Suhyun Cho, Do Hyeon Jeong, Kwang Hoon Lee
BACKGROUND: Current methods for evaluating efficacy of cosmetics have limitations because they cannot accurately measure changes in the dermis. Skin sampling using microneedles allows identification of skin-type biomarkers, monitoring treatment for skin inflammatory diseases, and evaluating efficacy of anti-aging and anti-pigmentation products. MATERIALS AND METHODS: Two studies were conducted: First, 20 participants received anti-aging treatment; second, 20 participants received anti-pigmentation treatment...
March 2024: Skin Research and Technology
https://read.qxmd.com/read/38423506/exposure-to-uv-radiation-in-lifeguards-on-barcelona-s-beaches-an-underestimated-occupational-risk
#9
JOURNAL ARTICLE
P Giavedoni, A Combalia, N Espinosa, J Aguilera, Susana Puig
BACKGROUND: The development of skin cancer is closely related to high exposure to UV radiation. Lifeguards are at an increased risk of excessive sun exposure. Objectives The main objective of this study was to measure the exposure of Barcelona's beach lifeguards to UV radiation. METHODS: Measurements in the work chair were taken every 30 minutes on a typical working day from 10:45 am to 19:15 pm. These measurements were carried out on four different days. These data were used to calculate the erythematous doses received during working hours, as well as those potentially received throughout the summer season...
February 27, 2024: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/38422282/maturation-and-antioxidant-activity-of-giombo-and-rama-forte-persimmons-produced-in-the-brazilian-semiarid
#10
JOURNAL ARTICLE
M C F Barbosa, M A S Morais, M F Melo, P A Souza, J D A Sarmento, P L D Morais
The objective of this work was characterizing persimmons of the 'Giombo' and 'Rama Forte' cultivars harvested at different ripening stages in the Brazilian semiarid. Fruits were harvested at three ripening stages - green, semi-ripe and ripe - then evaluated for the following characteristics: fruit weight and diameter, skin and pulp color, fruit firmness, pulp pH, soluble solids content, titratable acidity, SSC/TA ratio, total soluble sugars, reducing sugars, astringency index, and the contents of tannin, vitamin C, carotenoid, β-carotene, and total extractable polyphenols...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38421796/dietary-habits-in-adult-japanese-patients-with-vitiligo
#11
JOURNAL ARTICLE
Risa Hamada, Yoko Funasaka, Hidehisa Saeki, Naotaka Serizawa, Teppei Hagino, Yumiko Yano, Hiroshi Mitsui, Naoko Kanda
Vitiligo is an autoimmune skin disease with acquired depigmentation. Dietary habits may modulate the pathogenesis of vitiligo. We evaluated dietary habits in adult Japanese patients with nonsegmental vitiligo, and compared their results with those of age- and sex-matched controls. We also examined the relationship between dietary habits and Vitiligo Area Scoring Index (VASI), or vitiligo on different anatomical sites. The intakes of energy, nutrients, and foods in the participants were analyzed using a brief-type self-administered diet history questionnaire...
February 29, 2024: Journal of Dermatology
https://read.qxmd.com/read/38417857/oral-administration-of-apple-pectin-solution-improves-atopic-dermatitis-in-a-mouse-model
#12
JOURNAL ARTICLE
Asuka Fujisaki, Aya Matsui, Kosuke Shiki, Rika Tateishi, Tatsuki Itoh
The development of atopic dermatitis (AD) involves multiple factors. Three such factors are particularly important in AD onset: immune abnormalities, skin barrier dysfunction, and itching. Many studies report that an imbalance between helper T (Th)1 and Th2 cells causes AD. Apple pectin, a prebiotic, has preventative effects in other allergic diseases (e.g., bronchial asthma and AD), but its potential benefits in AD are unclear. In this study, we investigated the effect of oral apple pectin administration on skin inflammation in an AD mouse model and examined changes in T cells involved in AD...
2024: Journal of Nutritional Science and Vitaminology
https://read.qxmd.com/read/38398782/retrospective-analysis-of-vitamin-d-deficiency-in-an-adult-population-of-arad-county-western-romania-2019-2022
#13
JOURNAL ARTICLE
Daniela Teodora Marti, Alexandru Nesiu, Cornel Balta, Tudor Rares Olariu, Alin Gabriel Mihu, Anca Hermenean, Daniela Adriana Oatis
Vitamin D, a steroid hormone synthesized primarily in the skin upon exposure to ultraviolet light, is widely deficient across global populations. This study aimed to fill the data gap in Western Romania by measuring 25-hydroxy-vitamin D levels in a cohort of 7141 from Arad County. It was observed that women, younger adults (18-29 years), and older adults (70-79 years) had notably lower vitamin D levels compared to the average population. Additionally, there was a rise in vitamin D levels over the four-year span of 2018-2022, coinciding with the COVID-19 pandemic...
February 18, 2024: Life
https://read.qxmd.com/read/38396804/the-potential-use-of-vitamin-d3-and-phytochemicals-for-their-anti-ageing-effects
#14
REVIEW
Kazuki Santa, Yoshio Kumazawa, Kenji Watanabe, Isao Nagaoka
Unlike other vitamins, vitamin D3 is synthesised in skin cells in the body. Vitamin D3 has been known as a bone-related hormone. Recently, however, it has been considered as an immune vitamin. Vitamin D3 deficiency influences the onset of a variety of diseases. Vitamin D3 regulates the production of proinflammatory cytokines such as tumour necrosis factor-α (TNF-α) through binding to vitamin D receptors (VDRs) in immune cells. Since blood levels of vitamin D3 (25-OH-D3) were low in coronavirus disease 2019 (COVID-19) patients, there has been growing interest in the importance of vitamin D3 to maintaining a healthy condition...
February 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38381779/vitamin-d-and-follicular-recruitment-in-the-in-vitro-fertilization-cycle
#15
JOURNAL ARTICLE
Roberto de A Antunes, Brenda M L de Melo, Maria do Carmo B de Souza, Marcelo M de Souza, Gabriela P S Melo, Thamires F M Jandre, Ana Cristina A Mancebo, Flavia L Conceição, Tania M Ortiga-Carvalho
OBJECTIVE: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation. METHODS: This is a retrospective study involving 267 patients undergoing in vitro fertilization (IVF) carried out in the Fertipraxis clinic, a private practice facility...
February 21, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38367122/reconstructed-human-skin-with-hypodermis-shows-essential-role-of-adipose-tissue-in-skin-metabolism
#16
JOURNAL ARTICLE
Jonas Jäger, Irit Vahav, Maria Thon, Taco Waaijman, Bas Spanhaak, Michael de Kok, Ranjit K Bhogal, Susan Gibbs, Jasper J Koning
BACKGROUND: Dysregulation of skin metabolism is associated with a plethora of diseases such as psoriasis and dermatitis. Until now, reconstructed human skin (RhS) models lack the metabolic potential of native human skin, thereby limiting their relevance to study human healthy and diseased skin. We aimed to determine whether incorporation of an adipocyte-containing hypodermis into RhS improves its metabolic potential and to identify major metabolic pathways up-regulated in adipose-RhS...
February 17, 2024: Tissue Engineering and Regenerative Medicine
https://read.qxmd.com/read/38365463/vitamin-d-deficiency-or-resistance-and-hypophosphatemia
#17
REVIEW
Vijaya Sarathi, Melkunte Shanthaiah Dhananjaya, Manjiri Karlekar, Anurag Ranjan Lila
Vitamin D is mainly produced in the skin (cholecalciferol) by sun exposure while a fraction of it is obtained from dietary sources (ergocalciferol). Vitamin D is further processed to 25-hydroxyvitamin D and 1,25-dihydroxy vitamin D (calcitriol) in the liver and kidneys, respectively. Calcitriol is the active form which mediates the actions of vitamin D via vitamin D receptor (VDR) which is present ubiquitously. Defect at any level in this pathway leads to vitamin D deficient or resistant rickets. Nutritional vitamin D deficiency is the leading cause of rickets and osteomalacia worldwide and responds well to vitamin D supplementation...
March 2024: Best Practice & Research. Clinical Endocrinology & Metabolism
https://read.qxmd.com/read/38364910/vitamin-d-deficiency-increases-the-risk-of-diabetic-peripheral-neuropathy-in-elderly-type-2-diabetes-mellitus-patients-by-predominantly-increasing-large-fiber-lesions
#18
JOURNAL ARTICLE
Sijia Fei, Jingwen Fan, Jiaming Cao, Huan Chen, Xiaoxia Wang, Qi Pan
AIMS: This study explores the link between Vitamin D deficiency (VDD) and diabetic peripheral neuropathy (DPN) in elderly type 2 diabetes mellitus (T2DM) patients. METHODS: Involving 257 elderly T2DM patients, the study utilized propensity score matching to balance age, sex, and diabetes duration. VDD was defined as serum 25-hydroxyvitamin D [25(OH)D] levels below 20 ng/ml. Large nerve fiber lesions were evaluated by electromyogram, while small nerve fiber lesions were assessed by measuring skin conductance...
February 14, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38357060/painful-tender-localized-idiopathic-livedo-reticularis
#19
Yanci A Algarin, Robert Pariser
Livedo reticularis (LR) is a unique cutaneous condition characterized by a reddish-blue to purple, net-like cyanosis of the skin, often associated with disturbances in cutaneous blood flow. This case report discusses a 30-year-old woman with a history of Hashimoto thyroiditis, vitamin D deficiency, migraines, and goiter who presents with painful, localized LR on her right flank. Despite her extensive medical history, there were no significant findings in her laboratory and imaging studies, including a normal epidermis in skin biopsies...
January 2024: Curēus
https://read.qxmd.com/read/38350754/balancing-the-risks-and-benefits-of-sun-exposure-a-revised-position-statement-for-australian-adults
#20
JOURNAL ARTICLE
Rachel E Neale, Victoria Beedle, Peter R Ebeling, Thomas Elliott, David Francis, Christian M Girgis, Louisa Gordon, Monika Janda, Graeme Jones, Robyn M Lucas, Rebecca S Mason, Philip Keith Monnington, Julia Morahan, Georgia Paxton, Craig Sinclair, Stephen Shumack, Jane Smith, Ann R Webb, David C Whiteman
OBJECTIVE: To describe the development of a new position statement regarding balancing the risks and benefits of sun exposure for Australian adults. METHODS: We conducted a Sun Exposure Summit in March 2021, with presentations from invited experts and a workshop including representation from academic, clinical, policy, and patient stakeholder organisations. The group considered advice about balancing the risks and benefits of sun exposure for Australian adults and developed a revised consensus position statement...
January 18, 2024: Australian and New Zealand Journal of Public Health
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