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Living donor transplant

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https://www.readbyqxmd.com/read/29026878/robotic-assisted-live-donor-ileal-segmentectomy-for-intestinal-transplantation
#1
Guosheng Wu, Qianjing Li, Qingchuan Zhao, Weizhong Wang, Hai Shi, Mian Wang, Jianyong Zheng, Mengbing Li, Daiming Fan
BACKGROUND: Every effort should be made to optimize surgical techniques and to minimize potential morbidity rates associated with live donor operations. Advances in a minimally invasive approach by robotic surgery to donor nephrectomy have raised the possibility of applying this technique to live donor bowel resections for intestinal transplantation. METHODS: We report the first 5 consecutive cases of a robotic-assisted live donor ileal segmentectomy. We describe the technical aspects of the procedure, discuss the rationale for considering this option, and evaluate potential advantages of this approach...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29026876/avoiding-icu-admission-by-using-a-fast-track-protocol-is-safe-in-selected-adult-to-adult-live-donor-liver-transplant-recipients
#2
Juan Echeverri, Nicolas Goldaracena, Akhil Kant Singh, Gonzalo Sapisochin, Nazia Selzner, Mark S Cattral, Paul D Greig, Les Lilly, Ian D McGilvray, Gary A Levy, Anand Ghanekar, Eberhard L Renner, David R Grant, Stuart A McCluskey, Markus Selzner
BACKGROUND: We evaluated patient characteristics of live donor liver transplant (LDLT) recipients undergoing a fast-track protocol without intensive care unit (ICU) admission versus LDLT patients receiving posttransplant ICU care. METHODS: Of the 153 LDLT recipients, 46 patients were included in our fast-track protocol without ICU admission. Both, fast-tracked patients and ICU-admitted patients were compared regarding donor and patient characteristics, perioperative characteristics, and postoperative outcomes and complications...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29026734/cytomegalovirus-infection-under-a-hybrid-strategy-in-pediatric-liver-transplantation-a-single-center-experience
#3
Ryung Kim, Dai Joung, Sunghee Lee, Insook Jeong, Seak Hee Oh, Jung-Man Namgoong, Dae Yeon Kim, Kyung Mo Kim
PURPOSE: To evaluate the outcomes of a hybrid prophylactic strategy to prevent cytomegalovirus (CMV) disease in pediatric liver transplantation (LT) patients. METHODS: CMV DNAemia was regularly monitored by quantitative nucleic acid amplification test (QNAT) and was quantified in all children. CMV infection and disease were defined according to the International Consensus Guidelines. The hybrid strategy against CMV infection consisted of universal 3-week prophylaxis and preemptive treatment of intravenous ganciclovir regardless of the recipient's serostatus...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29026597/endoscopic-approach-for-management-of-biliary-strictures-in-liver-transplant-recipients-a-systematic-review-and-meta-analysis
#4
Dayse Pereira da Silva Aparício, José Pinhata Otoch, Edna Frasson de Souza Montero, Muhammad Ali Khan, Everson Luiz de Almeida Artifon
The most common biliary complication after liver transplantation is anastomotic stricture (AS) and it can occur isolated or in combination with other complications. Liver graft from a cadaveric donor or a living donor has an influence on the incidence of biliary strictures as well as on the response to endoscopic treatment. Endoscopic treatment using balloon dilation and insertion of biliary stents by endoscopic retrograde cholangiopancreatography (ERCP) is the initial approach to these complications. AIM: The aim of this article is to compare different endoscopic techniques to treat post-liver transplantation biliary strictures...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29025382/biliary-complications-in-recipients-of-living-donor-liver-transplant-a-single-center-review-of-120-patients
#5
Mohamed D Sarhan, Ayman M A Osman, Mahmoud Aly Mohamed, Omar Abdelaziz, Dalia K Serour, Doaa A Mansour, Sherif Mogawer, Ayman S Helmy, Mostafa A El-Shazli, Adel A Hosny
OBJECTIVES: Biliary complications are common after living-donor liver transplant. This retrospective study reviewed our experience with biliary complications in recipients of living-donor liver transplant. MATERIALS AND METHODS: Over our 9-year study period, 120 patients underwent living-donor liver transplant. Patients were divided into 2 groups, with group A having biliary complications and group B without biliary complications. Both groups were compared, and different treatment modalities for biliary complications were evaluated...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29024716/accelerated-humoral-renal-allograft-rejection-due-to-hla-c14-mediated-allosensitization-to-hla-bw6
#6
Stephen P Persaud, Brian Duffy, Donna L Phelan, Thalachallour Mohanakumar, Rowena Delos Santos, Joseph P Gaut, Chang Liu
OBJECTIVES: To investigate immunological mechanisms underlying accelerated antibody-mediated rejection (AMR) of a living-related renal allograft in a patient with no detectable antibodies to donor human leukocyte antigens (HLA) in pre-transplant sera. METHODS: Pre- and post-transplant HLA antibody specificities were determined by single-antigen bead assay, and crossmatching was performed by flow cytometry- and complement-dependent cytotoxicity-based methods. Intermediate- and high-resolution HLA typing were performed by molecular methods...
October 9, 2017: Human Immunology
https://www.readbyqxmd.com/read/29024412/risk-of-post-transplant-hepatocellular-carcinoma-recurrence-is-greater-in-recipients-with-higher-platelet-counts-in-living-donor-liver-transplantation
#7
Sangbin Han, Sanghoon Lee, Ju Dong Yang, Michael Douglas Leise, Joong Hyun Ahn, Seonwoo Kim, Gangha Jung, Mi Sook Gwak, Gaab Soo Kim, Justin Sangwook Ko
Platelets interact with tumor cells and promote metastasis. The importance of platelets in post-transplant hepatocellular carcinoma (HCC) recurrence is unclear. Thus, we aimed to evaluate the association between preoperative platelet count and HCC recurrence after living donor liver transplantation. Of 359 recipients of livers from living donors for HCC, 209 of 240 patients who had preoperative platelet count ≤75 × 10(9) /L were matched with 97 of 119 patients who had preoperative platelet count >75 × 10(9) /L using propensity score matching, with an unfixed matching ratio based on factors such as tumor biology...
October 11, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29024347/long-term-outcome-of-rendezvous-technique-for-hepaticojejunal-anastomotic-obstruction-after-pediatric-living-donor-liver-transplantation
#8
Yukihiro Sanada, Tomonori Yano, Taizen Urahashi, Yoshiyuki Ihara, Noriki Okada, Naoya Yamada, Yuta Hirata, Takumi Katano, Hironori Yamamoto, Koichi Mizuta
No abstract text is available yet for this article.
October 12, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29024048/the-impact-of-adult-to-adult-living-donor-liver-transplantation-on-transplant-center-outcomes-reporting
#9
John F Renz, Geraldine C Diaz
BACKGROUND: The Scientific Registry of Transplant Recipients (SRTR) has released a 5-tier performance ranking system based upon results of deceased-donor and living-donor liver transplantation. MATERIALS AND METHODS: An analysis of Spring 2017 SRTR Program Specific Reports for outcomes of adult living-donor and deceased-donor liver transplantation. RESULTS: Utilizing the current SRTR performance algorithm, living-donor liver transplant results may disproportionately affect transplant center performance ranking...
October 12, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29023959/pembrolizumab-for-metastatic-hepatocellular-carcinoma-following-live-donor-liver-transplantation-the-silver-bullet
#10
A Rammohan, M S Reddy, M Farouk, J Vargese, M Rela
Therapeutic options for extrahepatic metastases following Liver Transplantation(LT) for Hepatocellular carcinoma(HCC) are limited, and the prognosis remains poor. Innovative blockade of immune checkpoints, such as monoclonal antibodies against programmed death receptor 1 have shown promise in the treatment of solid organ malignancies. Here, we report a case of metastatic HCC after LT, where Pembrolizumab was started following a poor response with Sorafenib. There was a complete radiological response to the drug with no liver graft rejection or dysfunction...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29022123/assessment-of-a-closed-wash-system-developed-for-processing-living-donor-femoral-heads
#11
M J Eagle, J Man, P Rooney, T A McQuillan, G Galea, J N Kearney
NHS Blood and Transplant Tissue and Eye Services (TES) and Scottish National Blood Transfusion Services Tissues and Cells Directorate (TCD) currently bank whole, frozen femoral head bone from living donors who are undergoing primary hip replacement surgery. When required, the bone is issued to a surgeon still frozen on dry ice (- 79 °C). Consequently, the femoral head bone is not processed, is not sterilised and at the time of issue, it contains donor blood, bone marrow and associated cells. We have previously shown that, cut, shaped and washed bone from deceased donors can be processed to remove up to 99...
October 11, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28993303/the-lived-experience-of-being-evaluated-for-organ-donation-focus-groups-with-living-kidney-donors
#12
Camilla S Hanson, Angelique F Ralph, Karine E Manera, John S Gill, John Kanellis, Germaine Wong, Jonathan C Craig, Jeremy R Chapman, Allison Tong
BACKGROUND AND OBJECTIVES: Comprehensive evaluations are required to safeguard voluntarism and minimize harm to living kidney donors. This process is lengthy, invasive, and emotionally challenging, with up to one fifth of potential donors opting out. We aimed to describe donors' experiences of the evaluation process. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted 14 focus groups involving 123 kidney donors who completed donation from three transplant centers (Australia and Canada)...
October 9, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28992338/the-association-of-donor-and-recipient-age-with-graft-survival-in-paediatric-renal-transplant-recipients-in-a-european-society-for-paediatric-nephrology-european-renal-association-european-dialysis-and-transplantation-association-registry-study
#13
Nicholas C Chesnaye, Karlijn J van Stralen, Marjolein Bonthuis, Jaap W Groothoff, Jérôme Harambat, Franz Schaefer, Nur Canpolat, Arnaud Garnier, James Heaf, Huib de Jong, Søren Schwartz Sørensen, Burkhard Tönshoff, Kitty J Jager
Background: The impact of donor age in paediatric kidney transplantation is unclear. We therefore examined the association of donor-recipient age combinations with graft survival in children. Methods: Data for 4686 first kidney transplantations performed in 13 countries in 1990-2013 were extracted from the ESPN/ERA-EDTA Registry. The effect of donor and recipient age combinations on 5-year graft-failure risk, stratified by donor source, was estimated using Kaplan-Meier survival curves and Cox regression, while adjusting for sex, primary renal diseases with a high risk of recurrence, pre-emptive transplantation, year of transplantation and country...
September 15, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28991245/secondary-solid-cancer-following-hematopoietic-cell-transplantation-in-patients-with-thalassemia-major
#14
S Santarone, A Pepe, A Meloni, A Natale, L Pistoia, P Olioso, G Papalinetti, L Cuccia, A Spasiano, R Lisi, M Di Ianni, T Bonfini, P Accorsi, S Salvadori, F Papola, S Angelini, P Di Bartolomeo
Hematopoietic cell transplant (HCT) recipients have a substantial risk of developing secondary solid cancers (SSCs). The aim of this retrospective study was to compare the incidence of SSC in a monocentric cohort of thalassemia major (TM) patients (n=122) who received HCT versus an hematopoietic cell donor monocentric cohort (n=122) and versus a large multicenter cohort of age- and sex-matched TM patients (n=244) who received conventional therapy. With a median follow-up of 24 years, 8 transplanted patients were diagnosed with SSC at a median of 18 years after HCT and at a median age of 33 years...
October 9, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28991124/angiogenesis-in-the-transplanted-donor-graft-after-living-donor-liver-transplantation
#15
Dong-Hwan Jung, Sung-Hwan Moon, Soon-Jung Park, Eun Jae Kim, In Ho Jang, Cheon-Soo Park, Ji Yoon Lee, Yong-Pil Cho, Sung-Gyu Lee
BACKGROUND: There is no direct evidence for the role of angiogenesis in liver regeneration in humans. This study aimed to determine whether angiogenesis is involved in the regeneration of transplanted donor grafts in human living-donor liver transplantation (LDLT) and to examine the impact of donor graft volume on angiogenesis. METHODS: Clinical data and liver tissue characteristics were analyzed in 4 patients who received adult-to-adult LDLT with dual left lobe grafts from 2 living donors...
October 5, 2017: Transplantation
https://www.readbyqxmd.com/read/28989997/diaphragmatic-hernia-following-liver-resection-case-series-and-review-of-the-literature
#16
Francesco Esposito, Chetana Lim, Chady Salloum, Michael Osseis, Eylon Lahat, Philippe Compagnon, Daniel Azoulay
BACKGROUNDS/AIMS: Postoperative diaphragmatic hernia, following liver resection, is a rare complication. METHODS: Data of patients who underwent major hepatectomy for liver tumors, between 2011 and 2015 were retrospectively reviewed. The literature was searched for studies reporting the occurrence of diaphragmatic hernia following liver resection. RESULTS: Diaphragmatic hernia developed in 2.3% of patients (3/131) with a median delay of 14 months (4-31 months)...
August 2017: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/28987015/center-practice-drives-variation-in-choice-of-u-s-kidney-transplant-induction-therapy-a-retrospective-analysis-of-contemporary-practice
#17
V R Dharnidharka, A S Naik, D A Axelrod, M A Schnitzler, Z Zhang, S Bae, D L Segev, D C Brennan, T Alhamad, R Ouseph, N N Lam, M Nazzal, H Randall, B L Kasiske, M McAdams-Demarco, K L Lentine
To assess factors that influence the choice of induction regimen in contemporary kidney transplantation, we examined center-identified, national transplant registry data for 166,776 US recipients (2005-2014). Bi-level hierarchical models were constructed, wherein use of each regimen was compared pairwise with use of interleukin-2 receptor blocking antibodies (IL2rAb). Overall, 81.8% of patients received induction, including thymoglobulin (TMG, 46.0%), IL2rAb (21.9%), alemtuzumab (ALEM, 12.5%), and other agents (1...
October 7, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28985203/cell-therapy-for-diverse-central-nervous-system-disorders-inherited-metabolic-diseases-and-autism
#18
REVIEW
Jessica M Sun, Joanne Kurtzberg
The concept of utilizing human cells for the treatment of medical conditions is not new. In its simplest form, blood product transfusion as treatment of severe hemorrhage has been practiced since the 1800s. The advent of hematopoietic stem cell transplantation (HSCT) began with the development of bone marrow transplantation for hematologic malignancies in the mid-1900s and is now standard of care for many hematologic disorders. In the past few decades, HSCT has expanded to additional sources of donor cells, a wider range of indications, and the development of novel cell products...
October 6, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28984750/postoperative-changes-of-liver-enzymes-can-distinguish-between-biliary-stricture-and-graft-rejection-after-living-donor-liver-transplantation-a-longitudinal-study
#19
Young Sik Woo, Kwang Hyuck Lee, Kyu Taek Lee, Jong Kyun Lee, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh, Danbee Kang, Juhee Cho
There is no known useful clinical parameter that can specifically predict a biliary stricture and differentiate it from other related complications after living donor liver transplantations (LDLT). The aims of this study were to determine whether the changes of liver enzymes can predict postoperative biliary stricture apart from other complications. We reviewed the medical records of 203 patients who underwent LDLT with duct to duct anastomosis from 2008 to 2010. The longitudinal changes of liver enzyme over time and the occurrence of complication were evaluated...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28983725/liver-transplantation-for-biliary-atresia-a-systematic-review
#20
REVIEW
Mureo Kasahara, Koji Umeshita, Seisuke Sakamoto, Akinari Fukuda, Hiroyuki Furukawa, Shinji Uemoto
Biliary atresia (BA) is an idiopathic neonatal cholangiopathy characterized by progressive inflammatory obliteration of the intrahepatic or extrahepatic bile ducts. Although the Kasai operation has dramatically improved the outcomes in children with BA, most patients with BA eventually require liver transplantation (LT) even after undergoing a successful Kasai procedure. The Japanese LT Society (JLTS) was established in 1980 to characterize and follow trends in patient characteristics and the graft survival among all liver transplant patients in Japan...
October 5, 2017: Pediatric Surgery International
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