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Living donor transplant

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https://www.readbyqxmd.com/read/29904381/the-calcineurin-inhibitor-tacrolimus-specifically-suppresses-human-t-follicular-helper-cells
#1
Elizabeth F Wallin, Danika L Hill, Michelle A Linterman, Kathryn J Wood
Background: T follicular helper (Tfh) cells are key players in the production of antibody-producing B cells via the germinal center reaction. Therapeutic strategies targeting Tfh cells are important where antibody formation is implicated in disease, such as transplant rejection and autoimmune diseases. We investigated the impact of the immunosuppressive agent tacrolimus on human Tfh cell differentiation and function in transplant recipients. Methods: Paired blood and lymph node (LN) samples were obtained from 61 transplant recipients immediately prior to organ implantation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29902957/is-muscle-meld-a-more-promising-predictor-for-mortality-after-living-donor-liver-transplantation
#2
Amr Badawy, Toshimi Kaido, Yuhei Hamaguchi, Takayuki Anazawa, Shintaro Yagi, Ken Fukumitsu, Naoko Kamo, Hideaki Okajima, Shinji Uemoto
BACKGROUND: To improve the outcome of living donor liver transplantation (LDLT), a scoring system that could predict accurately the patient and graft survival posttransplant is necessary. The aim of this study is to evaluate our previously proposed Muscle-model for end-stage liver disease (M-MELD) score and to compare it with the other available scores to find the best system that correlates with postoperative outcome after liver transplant. METHODS: We retrospectively reviewed the data of 199 patients who underwent LDLT from January 2010 to July 2016 and calculated the preoperative MELD, MELD Na, the product of donor age and MELD (D-MELD), M-MELD, integrated MELD, and the balance of risk (BAR) score in all patients...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29900661/allograft-and-patient-survival-after-sequential-hsct-and-kidney-transplantation-from-the-same-donor-a-multicenter-analysis
#3
Michael Eder, Christoph Schwarz, Michael Kammer, Niels Jacobsen, Stavroula Masouridi Levrat, Morton J Cowan, Tepsiri Chongkrairatanakul, Robert Gaston, Rommel Ravanan, Hideki Ishida, Anette Bachmann, Sergio Alvarez, Martina Koch, Cyril Garrouste, Ulrich A Duffner, Brett Cullis, Nicolaas Schaap, Michael Medinger, Søren Schwartz Sørensen, Eva-Maria Dauber, Georg Böhmig, Heinz Regele, Gabriela A Berlakovich, Thomas Wekerle, Rainer Oberbauer
Tolerance induction through simultaneous hematopoietic stem cell- and renal transplantation has shown promising results, but it is hampered by the toxicity of preconditioning therapies and graft-versus-host disease. Moreover, renal function has never been compared to conventionally transplanted patients, thus, whether donor-specific tolerance results in improved outcomes remains unanswered. We collected follow-up data of published cases of renal transplantations after hematopoietic stem cell transplantation from the same donor and compared patient- and transplant kidney survival- as well as function with caliper-matched living-donor renal transplantations from the Austrian dialysis and transplant registry...
June 13, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29898644/a-scoping-review-of-the-literature-on-public-solicitations-for-living-organ-and-hematopoietic-stem-cell-donations
#4
Ruby Rajendra Shanker, Samantha J Anthony, Linda Wright
INTRODUCTION: Evolving methods of communication have increased public appeals for living organ and hematopoietic stem cell donations from strangers, giving public solicitations more visibility. Within the academic literature, perspectives have been divisive, reflecting ethical justifications for and against appeals for living unrelated donors. Transplant programs and clinicians face a variety of ethical dilemmas when patients and their solicited donors present to the hospital. OBJECTIVE: A scoping review methodology was designed to (1) explore the academic literature and (2) summarize and disseminate key research findings...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29898487/-renal-replacement-procedure-information-education-documentation
#5
Jan Galle, Jana Reitlinger
In renal replacement therapy, different methods are available: hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KTx). In addition, variants can be used: HD as a home HD or center HD, PD as a conventional PD or automated (cycler) PD, KTx as a potentially short-term predictable living donation or conventional donor kidney donation. The patient and his familiar or caring environment must be informed accordingly. This means first of all: information about which procedures of kidney replacement therapy are possible and can be offered...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29896575/sclerosing-encapsulating-peritonitis-after-living-donor-liver-transplantation-a-case-series-kyoto-experience
#6
Vusal Aliyev, Shintaro Yagi, Ahmed Hammad, Amr Badawy, Yudai Sasaki, Yuki Masano, Gen Yamamoto, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shinji Uemoto
Sclerosing encapsulating peritonitis (SEP), or abdominal cocoon is a rare cause of intestinal obstruction, and still etiology remains unknown. We report a series of 4 patients with abdominal cocoon, and all the 4 patients had previously undergone living-donor liver transplantation (LDLT). There was no evidence of SEP before and during LDLT. At the time of diagnosis of SEP, 3 out of 4 patients had ascites. First and fourth patients had multiple episodes or attacks of cholangitis, which were managed by percutaneous transhepatic biliary drainage and hepaticojejunostomy, respectively...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29896574/management-of-very-late-peritoneal-metastasis-of-hepatocellular-carcinoma-10-years-after-liver-transplantation-lessons-from-two-cases
#7
Abdulwahab A Alshahrani, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Dong-Hwan Jung, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Su-Min Ha, Yo-Han Park, Sung-Gyu Lee
Recurrence of hepatocellular carcinoma (HCC) 10 years after liver transplantation (LT) is very rare. Here, we present two cases of peritoneal metastasis of HCC that occurred 10 and 12 years after LT. A 77-year-old male who had undergone deceased-donor LT 10 years earlier showed slow progressive elevation of tumor marker levels over 6 months. Close observation with frequent imaging studies and monthly tumor marker analyses revealed a solitary peritoneal seeding mass. Imaging studies revealed that the mass was highly likely to be metastatic HCC...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
https://www.readbyqxmd.com/read/29894414/risk-factors-and-clinical-course-for-liver-steatosis-or-nonalcoholic-steatohepatitis-after-living-donor-liver-transplantation
#8
Hisamitsu Miyaaki, Satoshi Miuma, Naota Taura, Hidetaka Shibata, Ryu Sasaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi, Kazuhiko Nakao
BACKGROUND: Posttransplant liver steatosis occurs frequently and can affect patient outcome. Our aim was to clarify the risk factors for steatosis or steatohepatitis after living donor liver transplantation (LT) through a retrospective examination of recent 100 living donor LT recipients and their liver donors. METHODS: Liver biopsy was performed at 1-year after LT and each year, thereafter, or as needed due to abnormal liver enzyme levels, with a median follow-up of 4 (2~10) years...
June 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29893956/pancreas-outcomes-between-living-and-deceased-kidney-donor-in-pancreas-after-kidney-transplantation-patients
#9
Pedro Ventura-Aguiar, Joana Ferrer, Ignacio Revuelta, David Paredes, Erika de Sousa-Amorim, Jordi Rovira, Enric Esmatjes, Juan Carlos Garcia-Valdecasas, Josep M Campistol, Federico Oppenheimer, Fritz Diekmann, Maria José Ricart
Background: Pancreas outcomes in pancreas after kidney transplantation (PAK) patients have been reported as being inferior to those of patients who receive simultaneous pancreas and kidney transplantation (SPK). The influence of the kidney donor (i.e. living versus deceased) has never been previously addressed. Methods: We retrospectively analysed all pancreas transplants performed in a single centre since 2007 and compared the outcomes between those patients who had previously received a living-donor kidney transplant (pancreas transplantation after living-donor kidney transplantation, PAldK; n = 18) or a deceased-donor kidney transplant (pancreas transplantation after deceased-donor kidney transplantation, PAddK; n = 28), using SPK (n = 139) recipients as a reference...
June 8, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29893464/lymphocyte-to-monocyte-ratio-is-a-predictor-of-survival-after-liver-transplantation-for-hepatocellular-carcinoma
#10
Yohei Mano, Tomoharu Yoshizumi, Kyohei Yugawa, Masafumi Ohira, Takashi Motomura, Takeo Toshima, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte-to-monocytes ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC. Patients were divided into high- (n = 126) and low- (n = 90) LMR groups...
June 12, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29892176/living-donor-liver-transplantation-for-acute-on-chronic-liver-failure-based-on-easl-clif-diagnostic-criteria
#11
Abu Bakar H Bhatti, Faisal S Dar, Muhammad O Butt, Eraj Sahaab, Mohammad Salih, Najmul H Shah, Nusrat Y Khan, Haseeb H Zia, Eitzaz U Khan, Nasir A Khan
Background: The European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) recently proposed diagnostic criteria for acute on chronic liver failure (ACLF). There is lack of data regarding liver transplant outcomes in ACLF patients based on these criteria. The objective of this study was to determine outcome following living donor liver transplantation (LDLT) in ACLF patients. Methods: We retrospectively reviewed patients who underwent LDLT for ACLF based on European association for the study of the liver and chronic liver failure consortium (EASL-CLIF) diagnostic criteria (group 1) ( N  = 60) and compared them with ACLF patients who did not undergo transplantation (group 2) ( N  = 59)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892175/outcome-of-living-donor-liver-transplantation-for-wilson-s-disease-in-adults-a-single-center-experience
#12
Narendra S Choudhary, Sanjiv Saigal, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Srinivasan Thiagrajan, Dheeraj Gautam, Deepak Govil, Vijay Vohra, Arvinder S Soin
Introduction: Although liver transplantation is a definitive cure for Wilson's disease (WD), there is limited data about results of living donor liver transplantation (LDLT) in adults. Material and methods: 18 adults underwent LDLT for WD. The presentations before LDLT were decompensated cirrhosis ( n  = 16), acute on chronic liver failure ( n  = 1) and acute liver failure ( n  = 1). The donors were parents ( n  = 2), siblings ( n  = 3), cousin ( n  = 1), daughter ( n  = 1), nephew ( n  = 1), spouse or relatives of spouse ( n  = 9) and from swap transplantation ( n  = 1)...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892174/living-donor-liver-transplantation-using-small-for-size-grafts-does-size-really-matter
#13
Pulkit Sethi, Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
Background: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR) > 0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR < 0.8) versus normal-sized grafts (GRWR > 0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29892173/efficacy-and-safety-of-sofosbuvir-based-regimens-for-treatment-of-hepatitis-c-recurrence-after-living-donor-liver-transplantation-an-experience-from-india
#14
Narendra S Choudhary, Sanjiv Saigal, Dheeraj Gautam, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Arvinder S Soin
Introduction: Results of Sofosbuvir based regimens for hepatitis C (HCV) recurrence after liver transplantation are available from well-designed clinical trials. Most of the data is from deceased donor liver transplant (DDLT) setting, and data on "real world" experience for HCV recurrence after living donor liver transplantation (LDLT) is limited. Material and methods: Consecutive 78 patients who completed Sofosbuvir based HCV treatment after liver transplantation were included...
June 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29888810/short-and-midterm-results-for-internal-jugular-vein-extension-for-short-right-renal-vein-kidney-transplant
#15
Tony Lu, Stephanie G Yi, Jean Bismuth, Richard J Knight, A Osama Gaber, Carlos F Bechara
Renal transplantation remains the definitive treatment for end stage renal disease (ESRD). The shorter renal vein in right donor nephrectomies is associated with higher incidence of technical failure. We present here our experience with autologous internal jugular vein (IJV) conduits to facilitate living-donor transplants. Six patients underwent right, living-donor kidney transplant with simultaneous IJV harvest over a one year period. All had bilateral jugular duplex scans preoperatively, and were placed on aspirin 81 mg postoperatively...
June 11, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29882487/expression-signature-of-lysosomal-associated-transmembrane-protein-4b-in-hepatitis-c-virus-induced-hepatocellular-carcinoma
#16
Gaurav Roy, Papai Roy, Atanu Bhattacharjee, Mudassar Shahid, Mohammad Misbah, Subash Gupta, Mohammad Husain
INTRODUCTION: Hepatocellular carcinoma is a lethal disease worldwide and therefore the establishment of novel diagnostic biomarkers is imperative. In this study, it was hypothesized that an abnormal expression of the lysosomal-associated protein transmembrane 4 beta ( LAPTM4B) gene is crucial in the pathogenesis of hepatitis C virus-mediated hepatocellular carcinoma; hence we investigated the expression profile of LAPTM4B in hepatitis C virus-induced hepatocellular carcinoma. METHODS: A group of 189 consecutive patients (hepatitis C virus-related hepatocellular carcinoma as tumor cases; n=93, hepatitis C virus-related cirrhotics as disease controls; n=96) opting for living donor liver transplantation as a therapeutic surgical regimen were recruited with informed consent...
May 1, 2018: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29882099/the-impact-of-preoperative-hemoglobin-level-on-the-short-term-outcomes-after-living-donor-liver-transplantation
#17
Amr Badawy, Toshimi Kaido, Ahmed Hammad, Shintaro Yagi, Naoko Kamo, Atsushi Yoshizawa, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Preoperative anemia was reportedly associated with increased morbidity and mortality after various types of surgeries. However, its impact on the outcomes after liver transplantation has not been thoroughly investigated. METHODS: We retrospectively investigated the clinical outcome of 216 consecutive adult patients who underwent living donor liver transplantation at our institute between January 2010 and June 2017 and stratified them according to the hemoglobin level before transplant...
June 7, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29880370/endovascular-treatment-for-very-early-hepatic-artery-stenosis-following-living-donor-liver-transplantation-report-of-two-cases
#18
Y Goto, N Shirahama, S Sasaki, R Kawahara, H Sakai, H Ishikawa, T Hisaka, T Ogata, M Yasunaga, Y Akagi, H Tanaka, K Okuda
BACKGROUND: Some literature has reported on endovascular treatment for very early hepatic artery stenosis (HAS; within 2 weeks after liver transplantation, and has deemed endovascular treatment to be a contraindication because out of serious complications associated with the procedure. We report on 2 cases of very early HAS successfully treated with endovascular treatment after living-donor liver transplantation (LDLT). CASE 1: A 54-year-old woman underwent LDLT with a left liver graft...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880362/living-donor-liver-transplantation-in-hepatitis-c-virus-era-a-report-of-500-consecutive-cases-in-a-single-center
#19
M A Wahab, A Shehta, M Elshoubary, A M Yassen, M Elmorshedi, T Salah, A M Sultan, O Fathy, W R Elsarraf, U Shiha, K Zalata, A N Elghawalby, M Eldesoky, A Monier, R Said, A M Elsabagh, M Ali, A Kandeel, U Abdalla, M Aboelella, M Elsadany, E E Abdel-Khalek, A Marwan, F M ElMorsi, R Adly
BACKGROUND: Living donor liver transplantation (LDLT) is considered a safe alternative to deceased donor liver transplantation (DDLT). In Egypt, DDLT program is still awaited, making LDLT the only hope for patients with end-stage liver disease, mainly due to chronic hepatitis C virus (HCV) infection. The current study is conducted to evaluate our experience of LDLT and discuss the lessons learned from 500 consecutive cases in HCV area. METHODS: We reviewed the data of patients who underwent LDLT at Gastrointestinal Surgery Center, Mansoura University during the period between May 2004 and March 2017...
June 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29880361/role-of-adult-living-donor-liver-transplantation-in-the-treatment-of-hepatocellular-carcinoma-within-and-beyond-milan-criteria-a-comparative-study
#20
M C Pavel, S Sanchez Cabus, G Crespo, J Ferrer, C Fondevila, J Fuster, J C Garcia-Valdecasas
BACKGROUND AND AIMS: In the context of the shortage of donors, adult living donor liver transplantation (aLDLT) represents a feasible alternative for patients within as well as beyond the Milan criteria. METHODS: From 2001, we performed 42 aLDLTs for hepatocellular carcinoma (HCC). Sixteen of the recipients were within the Milan criteria, whereas 26 fulfilled the Barcelona-Clinic Liver Cancer Group (BCLC) expanded criteria (1 tumor ≤7 cm, 5 tumors ≤3 cm, or tumors 3 ≤5 cm without macrovascular invasion or down-staging to Milan after loco-regional therapies)...
June 2018: Transplantation Proceedings
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