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https://www.readbyqxmd.com/read/27857631/comparison-between-the-effects-of-passive-and-active-soft-tissue-therapies-on-latent-trigger-points-of-upper-trapezius-muscle-in-women-single-blind-randomized-clinical-trial
#1
Marzieh Mohammadi Kojidi, Farshad Okhovatian, Abbas Rahimi, Alireza Akbaezade Baghban, Hadi Azimi
OBJECTIVE: The purpose of this study was to investigate the effects of passive versus active soft tissue therapies on pain and ranges of motion in women with latent myofascial trigger points. METHODS: Forty-two female patients, aged 18 to 64 years, with a history of neck pain and latent myofascial trigger points in the upper trapezius muscle were randomly assigned to 3 groups: group A received passive soft tissue therapy, group B received active soft tissue therapy, and a control group C received a sham procedure...
December 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27828717/natural-killer-group-2a-expressed-on-both-peripheral-cd3-cd56-nk-cells-and-cd3-cd8-t-cells-plays-a-pivotal-negative-regulatory-role-in-the-progression-of-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#2
Rui-Tian Yi, Ying-Hua Niu, Hong-Li Liu, Tie-Ying Zhang, Yu-Cong Yang, Yu Zhang, Dong-Lin Yin, Tian-Yan Chen, Ying-Ren Zhao
To explore the role of surface receptors natural killer group 2A (NKG2A) and natural killer group 2D (NKG2D) on CD3(+)CD8(+)T cells and CD3(-)CD56(+)NK cells in the progression of hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), we measured the expression of NKG2A and NKG2D on the surface of these 2 types of circulating cells by flow cytometry in 3 groups. One group consists of 36 patients with chronic hepatitis B (CHB), another one consists of 22 patients with HBV-related ACLF, and the last one has 12 normal controls (NC)...
November 9, 2016: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/27822882/plasma-von-willebrand-factor-levels-predict-in-hospital-survival-in-patients-with-acute-on-chronic-liver-failure
#3
K S Prasanna, Ashish Goel, G Jayakumar Amirtharaj, Anup Ramachandran, K A Balasubramanian, Ian Mackie, Uday Zachariah, K G Sajith, Elwyn Elias, C E Eapen
BACKGROUND AND AIMS: Circulating levels of von Willebrand factor (vWF) predict mortality in patients with cirrhosis. We hypothesized that systemic inflammation in acute-on-chronic liver failure (ACLF) will stimulate endothelium, increase vWF levels, and promote platelet microthrombi causing organ failure. METHODS: In this prospective study, we correlated plasma vWF levels with organ failure, liver disease severity, sepsis, and systemic inflammatory response syndrome (SIRS) and also analyzed if vWF levels predicted in-hospital composite poor outcome (i...
November 8, 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27815438/the-acute-on-chronic-liver-failure-syndrome-or-when-the-innate-immune-system-goes-astray
#4
REVIEW
Joan Clària, Vicente Arroyo, Richard Moreau
The acute-on-chronic liver failure (ACLF) syndrome is characterized by acute decompensation of cirrhosis, organ failure, and high 28-d mortality. ACLF displays key features of systemic inflammation and its poor outcome is closely associated with exacerbated systemic inflammatory responses. In this review, we describe the prevailing characteristics of systemic inflammation in patients with decompensated cirrhosis and ACLF, with special emphasis on the principal features of the cytokine storm the mechanisms underlying this intense systemic inflammatory response (i...
November 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27788704/-screening-of-serum-biomarkers-by-isobaric-tags-for-relative-and-absolute-quantitation-in-patients-with-hbv-related-acute-on-chronic-liver-failure
#5
H M Liu, F Y Gao, H Yu, P P Meng, Y Y Jiang, X B Wang
Objective: To investigate the screening of serum biomarkers in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) by isobaric tags for relative and absolute quantitation (iTRAQ). Methods: Gel electrophoresis was used to isolate and remove high-abundant proteins. Each group of peptides was labeled by the iTRAQ reagents and then tested with an UltiMateTM 3000 nanoliter high-performance liquid chromatograph, and a Q-Exactive tandem mass spectrometer. The Protein Discovery software was used to analyze mass spectrometry data and perform bioinformatic analysis for differentially expressed proteins...
August 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27784430/-prognostic-value-of-a-logistic-regression-model-based-on-keratin-18-in-patients-with-hbv-related-liver-failure
#6
Q R Gan, X Y Jiang, X Zhang, M S Chen, C Pan
Objective: To investigate the association between serum keratin 18 (K18) level and prognosis in patients with HBV-related acute-on-chronic liver failure (ACLF). Methods: A total of 120 patients who visited Department of Hepatology in Fuzhou Infectious Disease Hospital and were diagnosed with HBV-related ACLF from December 2012 to March 2014 were enrolled and followed up for 3 months. The patients were divided into death group and survival group. The serum levels of K18 fragments (M30 and M65) were measured and related laboratory data were collected to analyze the differences in M30, M65, M30/M65, and other laboratory markers...
July 20, 2016: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/27775822/polymorphisms-in-the-interleukin-il-1-gene-cluster-influence-systemic-inflammation-in-patients-at-risk-for-acute-on-chronic-liver-failure
#7
José Alcaraz-Quiles, Esther Titos, Mireia Casulleras, Marco Pavesi, Cristina López-Vicario, Bibiana Rius, Aritz Lopategi, Andrea de Gottardi, Ivo Graziadei, Henning Gronbaek, Pere Ginès, Mauro Bernardi, Vicente Arroyo, Joan Clària
: Acute-on-chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short-term mortality. Recent findings suggest that an over-exuberant systemic inflammation plays a primary role in ACLF progression. In this study, we examined whether genetic factors shape systemic immune responses in patients with decompensated cirrhosis. Six single nucleotide polymorphisms (SNPs) in inflammation-related genes (IL-1β: rs1143623, IL-1ra: rs4251961, IL-10: rs1800871, SOCS3: rs4969170, NOD2: rs3135500 and CMKLR1: rs1878022) were genotyped in 279 cirrhotic patients with (n=178) and without (n=101) ACLF from the CANONIC study of the CLIF consortium...
October 24, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27771965/reviewing-the-diagnostic-criteria-for-acute-on-chronic-liver-failure
#8
Ankur Jindal, Archana Rastogi, Shiv Kumar Sarin
For over 20 years, acute-on-chronic liver failure (ACLF) has taken multiple definitions and/or classifications. The definition outlines the acute and chronic insults to include a homogenous patient group with liver failure and an expected outcome in a specific time frame. Early and accurate diagnosis is essential as this inflammation of the liver may tilt the balance of liver destruction and regeneration adversely. Various factors such as superadded systemic sepsis, liver reserve, cause of primary chronic liver disease, state of immune system or the state of gut microbial flora might determine the ultimate prognosis...
December 2016: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27768929/metabolite-variations-between-acute-on-chronic-liver-failure-and-chronic-liver-failure-caused-by-hepatitis-b-virus-based-on-ultra-performance-liquid-chromatography-mass-spectrometry
#9
Jiangshan Lian, Xiaofen Li, Yinyin Wang, Jianle Yang, Wei Liu, Jing Ma, Deying Chen, Lanjuan Li, Jianrong Huang
OBJECTIVE: The present study aims to compare serum metabolite alterations between acute-on-chronic liver failure (ACLF) and chronic liver failure (CLF), and find the specific biomarkers associated with the diseases. METHODS: Serum samples were collected from patients with ACLF (n=76) and CLF (n=56) as well as healthy individuals (n=20) and assayed by ultra-performance liquid chromatography mass spectrometry (UPLC-MS). The acquired data was analyzed using principal components analysis (PCA) and partial least squares discriminate analysis (PLS-DA)...
October 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27756698/a-study-of-acute-and-chronic-tissue-changes-in-surgical-and-traumatically-induced-experimental-models-of-knee-joint-injury-using-magnetic-resonance-imaging-and-micro-computed-tomography
#10
K M Fischenich, H M Pauly, K D Button, R S Fajardo, C E DeCamp, R C Haut, T L Haut Donahue
OBJECTIVE: The objective of this study was to monitor the progression of joint damage in two animal models of knee joint trauma using two non-invasive, clinically available imaging modalities. METHODS: A 3-T clinical magnet and micro-computed tomography (μCT) was used to document changes immediately following injury (acute) and post-injury (chronic) at time points of 4, 8, or 12 weeks. Joint damage was recorded at dissection and compared to the chronic magnetic resonance imaging (MRI) record...
October 15, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27750389/new-concepts-in-acute-on-chronic-liver-failure-implications-for-liver-transplantation
#11
Antonella Putignano, Thierry Gustot
Acute-on-Chronic Liver Failure (ACLF) is a recently defined syndrome that occurs frequently in patients with cirrhosis and is associated with a poor short-term prognosis. Currently, management of patients with ACLF is mainly supportive. Despite medical progress, this syndrome frequently leads to multi-organ failure, sepsis, and, ultimately, death. The results of attempts to use liver transplantation (LT) to manage this critical condition have been poorly reported but are promising. Currently, selection criteria of ACLF patients for LT, instructions for prioritization on the waiting list, and objective indicators for removal of ACLF patients from the waiting list in cases of clinical deterioration are poorly defined...
October 17, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27749778/lamivudine-improves-short-term-outcome-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure-patients-with-a-high-model-for-end-stage-liver-disease-score
#12
Xiaoshu Li, Fangyuan Gao, Huimin Liu, Henghui Zhang, Yao Liu, Xieqiong Ye, Mingfan Geng, Le Sun, Rui Wang, Yuxin Li, Yuyong Jiang, Xiaojing Wang, Guiqin Zhou, Zhiyun Yang, Ang Li, Hui Zeng, Xianbo Wang
AIM: Hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) has significant morbidity and mortality. There is no standard approach for the management of HBV-related ACLF with nucleos(t)ide analogs. Our objective was to compare the short-term mortality between entecavir (ETV) and lamivudine (LAM) in patients with HBV-related ACLF. METHODS: We recruited 311 inpatients with HBV-related ACLF from December 2002 to January 2015. The patients were treated with ETV (n=143) or LAM (n=168)...
January 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27747458/acute-on-chronic-liver-failure
#13
Shiv Kumar Sarin, Ashok Choudhury
Acute-on-chronic liver failure (ACLF) is a distinct entity that differs from acute liver failure and decompensated cirrhosis in timing, presence of treatable acute precipitant, and course of disease, with a potential for self-recovery. The core concept is acute deterioration of existing liver function in a patient of chronic liver disease with or without cirrhosis in response to an acute insult. The insult should be a hepatic one and presentation in the form of liver failure (jaundice, encephalopathy, coagulopathy, ascites) with or without extrahepatic organ failure in a defined time frame...
December 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/27746620/acute-on-chronic-liver-failure-what-is-in-a-definition
#14
REVIEW
Anil C Anand, Radha K Dhiman
Acute on chronic liver failure (ACLF) is a recently recognized syndrome and its definition has been evolving over last two decades. Currently, there is no universal consensus about the definition as kind of cases being seen in the Western world appear to be somewhat different from those that are seen in Asia Pacific region. But every one agrees that definition of ACLF should include following components. (a) The status of pre-existing liver disease, (b) defining the acute insult that leads to rapid deterioration of liver status, (c) time frame during which the acute insult can lead to rapid deterioration, (d) the quantification and definition of liver failure status after deterioration, which will determine the severity of ACLF, and (e) prediction of prognosis after analyzing first four components in the short and long terms...
September 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27730496/modification-in-csf-specific-gravity-in-acutely-decompensated-cirrhosis-and-acute-on-chronic-liver-failure-independent-of-encephalopathy-evidences-for-an-early-blood-csf-barrier-dysfunction-in-cirrhosis
#15
Nicolas Weiss, Matteo Rosselli, Sarah Mouri, Damien Galanaud, Louis Puybasset, Banwari Agarwal, Dominique Thabut, Rajiv Jalan
Although hepatic encephalopathy (HE) on the background of acute on chronic liver failure (ACLF) is associated with high mortality rates, it is unknown whether this is due to increased blood-brain barrier permeability. Specific gravity of cerebrospinal fluid measured by CT is able to estimate blood-cerebrospinal fluid-barrier permeability. This study aimed to assess cerebrospinal fluid specific gravity in acutely decompensated cirrhosis and to compare it in patients with or without ACLF and with or without hepatic encephalopathy...
October 11, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27722049/characteristics-of-cpg-islands-and-their-quasispecies-of-full-length-hepatitis-b-virus-genomes-from-patients-at-different-phases-of-infection
#16
Yuan Xue, Ming-Jie Wang, Su-Yuan Huang, Zhi-Tao Yang, De-Min Yu, Yue Han, Ming-Yu Zhu, Dao Huang, Dong-Hua Zhang, Qi-Ming Gong, Xin-Xin Zhang
BACKGROUND: CpG islands in hepatitis B virus (HBV) genome are potential targets for methylation mediated gene silencing, and may be involved in the pathogenesis of HBV infection. To date, their characteristics in HBV quasispecies (QS) remain largely unknown. The purpose of this study was to investigate the characteristics of CpG islands in HBV QS. METHODS: Forty patients diagnosed as acute hepatitis B (AHB, n = 10), immune-tolerant HBV carriers (IT, n = 9), chronic hepatitis B (CHB, n = 11), or acute on chronic liver failure (ACLF, n = 10), were enrolled in this case-control study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27720915/validation-of-a-staging-system-for-acute-kidney-injury-in-patients-with-cirrhosis-and-association-with-acute-on-chronic-liver-failure
#17
Patricia Huelin, Salvatore Piano, Elsa Solà, Marialuisa Stanco, Cristina Solé, Rebeca Moreira, Elisa Pose, Silvano Fasolato, Nuria Fabrellas, Glòria de Prada, Chiara Pilutti, Isabel Graupera, Xavier Ariza, Antonietta Romano, Chiara Elia, Andrés Cárdenas, Javier Fernández, Paolo Angeli, Pere Ginès
BACKGROUND & AIMS: In patients with cirrhosis of the liver, acute kidney injury (AKI) is classified into 3 stages. Recent studies indicate that there are 2 subgroups of stage 1 disease, associated with different outcomes and serum levels of creatinine (SCr): stage 1A (SCr <1.5 mg/dL) and stage 1B (SCr ≥1.5 mg/dL). We performed a prospective study to validate, in a large series of patients with cirrhosis, the association between this new description and patient outcomes, and assess the relationship between AKI stage and the presence of acute-on-chronic liver failure...
October 5, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27696493/time-trends-in-the-health-care-burden-and-mortality-of-acute-on-chronic-liver-failure-in-the-united-states
#18
Alina M Allen, W Ray Kim, James P Moriarty, Nilay D Shah, Joseph J Larson, Patrick S Kamath
: Acute on chronic liver failure (ACLF) is associated with multisystem organ failure and poor prognosis in hospitalized patients with cirrhosis. We aimed to determine time trends in the epidemiology, economic burden, and mortality of ACLF in the United States. The National Inpatient Sample database was queried between 2001 and 2011. ACLF was defined as two or more extrahepatic organ failures in patients with cirrhosis. The primary outcomes were trends in hospitalizations, hospital costs, and inpatient mortality...
October 3, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27687792/umbilical-cord-derived-mesenchymal-stem-cell-transplantation-in-hepatitis-b-virus-related-acute-on-chronic-liver-failure-treated-with-plasma-exchange-and-entecavir-a-24-month-prospective-study
#19
Yu-Hua Li, Ying Xu, Hua-Mei Wu, Jing Yang, Li-Hong Yang, Wan Yue-Meng
BACKGROUND & AIM: Search for an effective therapy for patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) remains an important issue. This study investigated the efficacy of umbilical cord-derived mesenchymal stem cell (UC-MSC) transplantation in patients with HBV-ACLF. METHODS: 45 consecutive entecavir-treated HBV-ACLF patients were prospectively studied. Among these patients, 11 received both plasma exchange (PE) and a single transplantation of UC-MSCs (group A), while 34 received only PE (group B)...
December 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27660136/patients-with-hbv-related-acute-on-chronic-liver-failure-have-increased-concentrations-of-extracellular-histones-aggravating-cellular-damage-and-systemic-inflammation
#20
X Li, C Gou, L Yao, Z Lei, T Gu, F Ren, T Wen
Acute-on-chronic liver failure (ACLF) is the most common type of liver failure and associated with grave consequences. Systemic inflammation has been linked to its pathogenesis and outcome, but the identifiable triggers are absent. Recently, extracellular histones, especially H4, have been recognized as important mediators of cell damage in various inflammatory conditions. This study aimed to investigate whether extracellular histones have clinical implications in patients with hepatitis B virus (HBV)-related ACLF...
September 23, 2016: Journal of Viral Hepatitis
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