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https://www.readbyqxmd.com/read/29762630/acute-on-chronic-liver-failure-in-china-rationale-for-developing-a-patient-registry-and-baseline-characteristics
#1
Wen-Yi Gu, Bao-Yan Xu, Xin Zheng, Jinjun Chen, Xian-Bo Wang, Yan Huang, Yan-Hang Gao, Zhong-Ji Meng, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Jia Shang, Hai Li, Shao-Yang Wang, Xin Sun, Hai Li
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus(HBV) are the main etiologies, respectively. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a multicenter prospective cohort with the same inclusion criteria and disease indicators as those used in the European CANONIC (Chronic liver failure-ACLF in Cirrhosis) study is urgently needed in Asia, where the prevalence of HBV is high...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29747694/clinical-performance-of-stem-cell-therapy-in-patients-with-acute-on-chronic-liver-failure-a-systematic-review-and-meta-analysis
#2
Ran Xue, Qinghua Meng, Jinling Dong, Juan Li, Qinwei Yao, Yueke Zhu, Hongwei Yu
BACKGROUND: Stem cell therapy has been applied in the treatment of acute-on-chronic liver failure (ACLF). However, its clinical efficiency is still debatable. The aim of this systematic review and meta-analysis is to evaluate the clinical efficiency of stem cell therapy in the treatment of ACLF. METHODS: The Cochrane Library, OVID, EMBASE, and PUBMED were searched to December 2017. Both randomized and non-randomized studies, assessing stem cell therapy in patients with ACLF, were included...
May 10, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29743800/a-case-of-acute-on-chronic-liver-failure-aclf-due-to-an-uncommon-acute-and-chronic-event
#3
Swastik Agrawal, Baldev S Rana, Suvradeep Mitra, Ajay Duseja, Ashim Das, Radha K Dhiman, Yogesh Chawla
Acute on Chronic Liver Failure (ACLF) is an acute worsening of patients with chronic liver disease resulting in liver failure. Usually these patients have cirrhosis as the underlying liver disease with alcohol being the most common etiology. Common hepatitic illnesses causing acute worsening in Indian patients of ACLF include alcoholic hepatitis, acute viral hepatitis related to hepatitis E virus and acute flare in chronic hepatitis B. We report an adult case of ACLF due acute viral hepatitis related to hepatitis A virus infection superimposed on nonalcoholic steatohepatitis without cirrhosis...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29743020/ifi16-is-involved-in-hbv-associated-acute-on-chronic-liver-failure-inflammation
#4
Xiuqing Pang, Xinhua Li, Zhishuo Mo, Jing Huang, Hong Deng, Ziying Lei, Xingrong Zheng, Zhiying Feng, Dongying Xie, Zhiliang Gao
BACKGROUND: Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the process of inflammation in viral infections. Our study sought to identify a correlation between IFI16 expression and inflammation in patients with chronic hepatitis B (CHB) and HBV-associated acute-on-chronic liver failure (HBV-ACLF). METHODS: We performed flow cytometry to measure IFI16 levels in peripheral blood mononuclear cells (PBMC) and used immunohistochemistry and western blotting to measure IFI16 protein levels in liver tissues...
May 9, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29739113/combination-of-micrornas-and-cytokines-a-method-for-better-evaluation-of-acute-on-chronic-liver-failure
#5
Chunwen Pu, Chunmeng Jiang, Lang Lang, Huang Hui, Zhidong Wang, Dapeng Ma, Yong Zhang
BACKGROUND: The aim was to establish expression profiles of microRNAs (miRNAs) in Peripheral Blood Mononuclear Cells (PBMC) and of plasma cytokines from the patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) and high-risk of acute-on-chronic liver failure (ACLF) patients as well as healthy people and to examine the relationships between these profiles and clinical features. METHODS: Herein, we collected PBMCs and plasma from peripheral blood of HBV-ACLF and ACLF patients as well as healthy people...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29735790/comparison-of-dynamic-changes-among-various-prognostic-scores-in-viral-hepatitis-related-acute-liver-failure
#6
Shalimar -, Ujjwal Sonika, Saurabh Kedia, Soumya J Mahapatra, Baibaswata Nayak, Dawesh P Yadav, Deepak Gunjan, Bhaskar Thakur, Harpreet Kaur, Subrat K Acharya
INTRODUCTION AND AIM: Multiple prognostic scores are available for acute liver failure (ALF). Our objective was to compare the dynamicity of model for end stage liver disease (MELD), MELD-sodium, acute liver failure early dynamic model (ALFED), chronic liver failure (CLIF)-consortium ACLF score and King's College Hospital Criteria (KCH) for predicting outcome in ALF. MATERIALS AND METHODS: All consecutive patients with ALF at a tertiary care centre in India were included...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29735787/a-dynamic-model-for-predicting-outcome-in-patients-with-hbv-related-acute-on-chronic-liver-failure
#7
Wei Lin, Jing Zhang, Xiaohui Liu, Hongqun Liu, Jinqiu He, Ming Li, Shuqin Zhang, Yuexin Zhang, Hong Chen, Changqing Zhang, Wenfang Wu, Chenggang Jin, Samuel S Lee, Zhongping Duan
INTRODUCTION AND AIM: Accurately predicting the prognosis of individual patient is crucial in the management of ACLF. We aimed to establish a specific prognostic model for HBV-related ACLF patients treated with nucleoside analog (NA). MATERIAL AND METHODS: We prospectively collected 205 ACLF cases diagnosed according to the APASL criteria. A dynamic prognostic model based on APASL criteria was established and validated. To demonstrate that the model is also applicable to those within EASL criteria, we divided the patients into two groups: met APASL criteria only (group A, n = 123); met both APASL and EASL criteria (group B, n = 82)...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29730473/the-intensive-care-unit-icu-course-and-outcome-in-acute-on-chronic-liver-failure-are-comparable-to-other-populations
#8
Philippe Meersseman, Lies Langouche, Johannie du Plessis, Hannelie Korf, Michaël Mekeirele, Wim Laleman, Frederik Nevens, Alexander Wilmer, Greet Van den Berghe, Schalk W van der Merwe
BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of cirrhosis, development of organ failure and high short term mortality. Whether the outcome in ACLF patients admitted to the ICU with organ failure differs from other ICU populations is unknown. We compared the clinical course and host response in ICU patients with or without ACLF, matched for baseline severity of illness scores and characteristics. METHODS: From the large prospective EPaNIC randomized control trial database (n=4640), 133 patients were identified with cirrhosis of whom 71 fulfilled the CLIF criteria for ACLF...
May 3, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29727380/human-mesenchymal-stem-cells-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure-a-systematic-review-with-meta-analysis
#9
Bin Chen, Yong-Hong Wang, Jin-Qin Qian, Dong-Bo Wu, En-Qiang Chen, Hong Tang
BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) is a condition with high mortality. New strategies are urgently required. The present review aims to provide a comprehensive understanding of the efficacy and safety of mesenchymal stem cells (MSC) treatment in patients with ACLF associated with hepatitis B virus infection. MATERIALS AND METHODS: The MEDLINE, Embase, and Cochrane Library databases were searched for the relevant publications. If appropriate, a meta-analysis was carried out for the following outcomes: survival rate, model for end-stage liver disease score, and liver function...
May 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29709681/class-iii-obesity-is-a-risk-factor-for-the-development-of-acute-on-chronic-liver-failure-in-patients-with-decompensated-cirrhosis
#10
Vinay Sundaram, Rajiv Jalan, Joseph C Ahn, Michael R Charlton, David S Goldberg, Constantine J Karvellas, Mazen Noureddin, Robert Wong
BACKGROUND AND AIMS: Acute on chronic liver failure (ACLF) is a syndrome of systemic inflammation and organ failures. Obesity, also characterized by chronic inflammation, is a risk factor among patients with cirrhosis for decompensation, infection, and mortality. Our aim was to test the hypothesis that obesity predisposes to ACLF development in patients with decompensated cirrhosis. METHODS: We examined the United Network for Organ Sharing (UNOS) database, from 2005-2016, characterizing patients at wait-listing as non-obese (BMI < 30), obese class I-II (BMI 30-39...
April 27, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29705887/analysis-of-the-high-incidence-of-acute-kidney-injury-associated-with-acute-on-chronic-liver-failure
#11
Nan Chen, Xiaohong Chen, Xiaoqiang Ding, Jie Teng
BACKGROUND: To investigate the incidence, risk, and prognostic factors of acute kidney injury (AKI) in acute-on-chronic liver failure (ACLF) patients. METHODS: A total of 188 patients were prospectively included and divided into AKI and non-AKI groups. Patients were followed at 1, 3, 7, 14, 28, 60, and 90 days after the onset of AKI. Significant risk factors were screened by univariate and Cox multivariate survival analyses to confirm the independent risk factors for 30- or 90-day mortality and the 90-day renal function recovery rate...
April 28, 2018: Hepatology International
https://www.readbyqxmd.com/read/29705264/neutrophil-to-lymphocyte-ratio-associates-independently-with-mortality-in-hospitalized-patients-with-cirrhosis
#12
Jonathan Rice, Jennifer L Dodge, Kiran M Bambha, Jasmohan S Bajaj, K Rajender Reddy, Jane Gralla, Dinesh Ganapathy, Robert Mitrani, Bradley Reuter, Julia Palecki, Chathur Acharya, Jawaid Shaw, James R Burton, Scott W Biggins
BACKGROUND & AIMS: The neutrophil to lymphocyte ratio (NLR) is a biomarker of immune dysregulation in patients with cirrhosis and is inexpensive to measure. We investigated the association between NLR and mortality in hospitalized patients with cirrhosis at 4 liver transplant centers, controlling for severity of acute-on-chronic liver failure (ACLF). METHODS: We performed a retrospective study using data from the North American Consortium for the Study of End-stage Liver Disease on patients with index hospitalizations for cirrhosis from December 2011 through December 2016...
April 26, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29696433/2d-shear-wave-elastography-combined-with-meld-improved-prognostic-accuracy-in-patients-with-acute-on-chronic-hepatitis-b-liver-failure
#13
Jie-Yang Jin, Yu-Bao Zheng, Jian Zheng, Jing Liu, Yong-Jiang Mao, Shi-Gao Chen, Zhi-Liang Gao, Rong-Qin Zheng
OBJECTIVES: To evaluate accuracy of two-dimensional shear wave elastography (2D SWE) and develop and validate a new prognostic score in predicting prognosis of acute-on-chronic liver failure (ACLF) patients. METHODS: From 1 October 2013 to 30 September 2015, we consecutively enrolled 290 patients, sequentially collected data (including 2D SWE, ultrasound parameters, laboratory data and prognostic scores) and recorded patients' outcome (recovering/steady or worsening) during a 90-day follow-up period...
April 25, 2018: European Radiology
https://www.readbyqxmd.com/read/29689120/acute-on-chronic-liver-failure-getting-ready-for-prime-time
#14
Jasmohan S Bajaj, Richard Moreau, Patrick S Kamath, Hugo E Vargas, Vicente Arroyo, K Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C Lai, Florence Wong
Acute on chronic liver failure (ACLF) is a culmination of chronic liver disease and extra-hepatic organ failures, which is associated with a high short-term mortality and immense healthcare expenditure. There are varying definitions for organ failures and ACLF in Europe, North America and Asia. These differing definitions need to be reconciled to enhance progress in the field. The pathogenesis of ACLF is multi-factorial and related to interactions between the immuno-inflammatory system, microbiota and the precipitating factors...
April 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29686702/mesenchymal-stem-cell-transplantation-for-liver-cell-failure-a-new-direction-and-option
#15
REVIEW
Yantian Cao, Bangjie Zhang, Rong Lin, Qingzhi Wang, Jie Wang, Fangfang Shen
Background and Aims: Mesenchymal stem cell transplantation (MSCT) became available with liver failure (LF), while the advantages of MSCs remain controversial. We aimed to assess clinical advantages of MSCT in patients with LF. Methods: Clinical researches reporting MSCT in LF patients were searched and included. Results: Nine articles ( n = 476) related with LF patients were enrolled. After MSCT, alanine aminotransferase (ALT) baseline decreased largely at half a month ( P < 0...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29675709/acid-base-status-and-its-clinical-implications-in-critically-ill-patients-with-cirrhosis-acute-on-chronic-liver-failure-and-without-liver-disease
#16
Andreas Drolz, Thomas Horvatits, Kevin Roedl, Karoline Rutter, Richard Brunner, Christian Zauner, Peter Schellongowski, Gottfried Heinz, Georg-Christian Funk, Michael Trauner, Bruno Schneeweiss, Valentin Fuhrmann
BACKGROUND: Acid-base disturbances are frequently observed in critically ill patients at the intensive care unit. To our knowledge, the acid-base profile of patients with acute-on-chronic liver failure (ACLF) has not been evaluated and compared to critically ill patients without acute or chronic liver disease. RESULTS: One hundred and seventy-eight critically ill patients with liver cirrhosis were compared to 178 matched controls in this post hoc analysis of prospectively collected data...
April 19, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29659382/tenofovir-versus-entecavir-for-the-treatment-of-acute-on-chronic-liver-failure-due-to-reactivation-of-chronic-hepatitis-b-with-genotypes-b-and-c
#17
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Xi-Nan Wu, Jin-Hui Yang
BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) can be triggered by reactivation of chronic hepatitis B (CHB). Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are now the most potent antiviral agents for CHB. This study aimed to compare the short-term safety and efficacy of TDF with ETV in the treatment of ACLF due to reactivation of CHB [hepatitis B virus (HBV)-ACLF]. PATIENTS AND METHODS: In total, 67 consecutive patients with HBV-ACLF were divided into TDF group (n=32) receiving daily TDF (300 mg/d) and ETV group (n=35) receiving daily ETV (0...
April 13, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29649629/qingchangligan-formula-alleviates-acute-liver-injury-by-attenuating-extracellular-histone-associated-inflammation
#18
Lan Ding, Xiangying Zhang, Li Li, Chunyan Gou, Xiaolan Luo, Yang Yang, Tao Wen, Xiuhui Li
Qingchangligan formula (QCLGF) is a traditional Chinese medicine that has exhibited remarkable clinical efficacy for patients with acute-on-chronic liver failure (ACLF). However, the hepatoprotective mechanisms of QCLGF are not completely understood. Extracellular histones were recently identified as the novel inflammatory mediators involved in the pathogenesis of acute liver injury. This study aimed to investigate whether QCLGF provides hepatoprotection by targeting extracellular histones. We showed that QCLGF significantly improved the survival rate of the ConA-treated mice, ameliorated hepatotoxicity, and markedly decreased the levels of extracellular histones and the associated cytokines...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29627486/association-of-red-blood-cell-distribution-width-with-severity-of-hepatitis-b-virus-related-liver-diseases
#19
Xiude Fan, Huan Deng, Xiqiang Wang, Siqi Fu, Zitong Liu, Jiao Sang, Xiaoge Zhang, Na Li, Qunying Han, Zhengwen Liu
BACKGROUND: Red blood cell distribution width (RDW) has been indicated to be an inflammatory indicator in a variety of diseases. However, no consistent conclusions regarding it's relevance to hepatitis B virus (HBV) -related liver diseases have been made. This meta-analysis was conducted to assess the significance of RDW in HBV-related liver diseases. METHODS: A comprehensive literature review was conducted using PubMed, Embase, and China National Knowledge Infrastructure (CNKI) through August 20, 2017 to identify studies that reported the association between RDW and HBV-related liver diseases...
April 5, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29623264/bacterial-infection-and-predictors-of-mortality-in-patients-with-autoimmune-liver-disease-associated-acute-on-chronic-liver-failure
#20
Xuan Zhang, Ping Chen, Hainv Gao, Shaorui Hao, Meifang Yang, Hong Zhao, Jianhua Hu, Weihang Ma, Lanjuan Li
Objective: To date, few studies are available on autoimmune liver disease-associated acute-on-chronic liver failure (ACLF). The aim of this study is to investigate bacterial infection and predictors of mortality in these patients. Methods: We retrospectively studied patients with autoimmune liver disease from August 2012 to August 2017. Clinical data of the patients were retrieved for analysis. Results: There were 53 ACLF patients and 53 patients without ACLF in this study...
2018: Canadian Journal of Gastroenterology & Hepatology
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