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Elizabeth Brunt, Shinichi Aishima, Pierre-Alain Clavien, Kathryn Fowler, Zachary Goodman, Gregory Gores, Annette Gouw, Alex Kagen, David Klimstra, Mina Komuta, Fukuo Kondo, Rebecca Miksad, Masayuki Nakano, Yasuni Nakanuma, Irene Ng, Valerie Paradis, Young Nyun Park, Alberto Quaglia, Massimo Roncalli, Tania Roskams, Michiie Sakamoto, Romil Saxena, Christine Sempoux, Claude Sirlin, Ashley Stueck, Swan Thung, W M S Tsui, Xin-Wei Wang, Aileen Wee, Hirohisa Yano, Matthew Yeh, Yoh Zen, Jessica Zucman-Rossi, Neil Theise
Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, due to lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue...
January 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
L Fenzl, K Bubel, M Mehrmann, G Schneider
Soft tissue tumors represent a special challenge in interdisciplinary cooperation. Malignant tumors require a multimodal therapy concept so that patient treatment in a specialized tumor center is recommended. The task of the surgeon in close cooperation with the radiologist is the resection of the tumor in sano with the required safety margin. The aim of diagnostic imaging is to describe the primary expansion of the tumor size and a possible tumor infiltration of adjacent compartments. The most important diagnostic imaging for this purpose is magnetic resonance imaging (MRI), especially T1-weighted fat-suppressed gadolinium-enhanced sequences...
January 2018: Der Radiologe
Ibrahim F Naldemir, Derya Guclu, H Baki Altınsoy, H Berk Canga, Omer Onbas
The occipital bone is a complex structure due to its anatomy and accessory sutures. Fracture - accessory suture differential diagnosis should be performed carefully in patients with a history of head trauma [4]. In this case report we wanted to emphasize that accessory sutures can be difficult to diagnose in patients with head trauma. We also specified the points to be considered in the suture - fracture differentional diagnosis. A bilateral, symmetrical fissure line was observed in the occipital bone basal part of the patient who was admitted to our emergency department due to head trauma...
March 2018: American Journal of Emergency Medicine
Ediz Coskun, Merve Ercin, Selda Gezginci-Oktayoglu
In this study, we aimed to research the effects of class-I HDACs and glucose on differentiation of pancreatic islet derived mesenchymal stem cells (PI-MSCs) to beta cells. Beta cell differentiation determined by flow cytometric analysis and gene expression levels of PDX1, PAX4, PAX6, NKX6.1, NGN3, INS2, and GLUT2. As a result the valproic acid, is an inhibitor of class-I HDACs, caused the highest beta cell differentiation in PI-MSCs. However, the cells in this group were at early stages of differentiation. Glucose co-administration to this group carried the differentiation to higher levels, but these newly formed beta cells were not functional...
January 2018: Journal of Cellular Biochemistry
Aker Fügen, Sayman Elif, Gümrükçü Gülistan, Doğan Meryem, Gürleyik Günay
Myofibroblastoma (MFB) is a benign tumor of the mammary stroma with predominant myofibroblastic differention. The cytologic reports of MFB are very few in the available literature. From the cytodiagnostic point of view about 21 cases of MFB with cytological evaluation by fine-needle aspiration cytology (FNAC) have been encountered in the English-language literature: A 35-year-old woman presented with lump in the left breast. FNAC showed mild degree of pleomorphism with occasional groups with fibrous stroma and tumoral cells...
December 2016: Diagnostic Cytopathology
Carla Gramaglia, Maria Cristina Rizza, Eleonora Gattoni, Eleonora Gambaro, Sarah Di Marco, Isabella Coppola, Annalisa Rossi, Amalia Jona, Fredrica Imperatori, Pierluigi Prosperini, Nunzia Chieppa, Valeria Binda, Serena Farruggio, Elena Grossini, Patrizia Zeppegno
OBJECTIVE: Asenapine, a second-generation antipsychotic, seems to be an effective and tolerable alternative to other treatments for patients with manic or mixed episodes. The objective of our naturalistic observational study was to identify asenapine responders and remitters and to compare responders vs. non-responders and remitters vs. non-remitters, as far as clinical and socio-demographic features are concerned. MATERIALS AND METHODS: We recruited patients with diagnosis of manic episode in bipolar I (BD I) or schizoaffective disorder, with clinical indication to asenapine treatment...
November 2014: Rivista di Psichiatria
Sungmin Woo, Jeong Yeon Cho
The prevalence of small renal masses (SRM) has risen, paralleling the increased usage of cross-sectional imaging. A large proportion of these SRMs are not malignant, and do not require invasive treatment such as nephrectomy. Therefore, differentiation between early renal cell carcinoma (RCC) and benign SRM is critical to achieve proper management. This article reviews the radiological features of benign SRMs, with focus on two of the most common benign entities, angiomyolipoma and oncocytoma, in terms of their common imaging findings and differential features from RCC...
January 2015: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Massimo Iavarone, Angelo Sangiovanni, Laura Virginia Forzenigo, Sara Massironi, Mirella Fraquelli, Alessio Aghemo, Guido Ronchi, Piero Biondetti, Massimo Roncalli, Massimo Colombo
UNLABELLED: Dynamic contrast imaging techniques are considered the standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in cirrhosis. However, the accuracy of radiological diagnosis depends largely on the degree of arterial hypervascularization, which increases with tumor size. Owing to the interplay and prognostic relevance of tumor vascularization and cell differentation, we asked ourselves whether tumor grade also affects the outcome of radiological diagnosis...
November 2010: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Zelal Bircan, Hatice Mutlu, Hae Il Cheong
PURPOSE: The causes of hereditary nephrogenic diabetes insipidus (HNDI) are the mutations in the arginine vasopressin V2 receptor gene (AVPR2) (90%) and aquaporin 2 gene (AQP2) (10%). Although it is possible to perform mutation analysis where available, differentional diagnosis at clinical bases remains valuable. METHODS: In this report we present two cases of HNDI diagnosed at clinical bases with a desmopressin infusion test as AQP2 gene mutations. The results were verified by genetic analysis to stress that a desmopressin infusion test is valuable for differential diagnosis of HNDI...
November 2010: Indian Journal of Pediatrics
Marina Antelo, Lilian Castro, Víctor Zamora, Ana Cabanne, Patricio Tanoue, Rodolfo Corti
BACKGROUND: Endoscopic biopsy is the most efficient way to obtain a biopsy specimen from neoplastic lesions located in the stomach. Therefore, it is the procedure of choice to obtain a histologic diagnosis of gastric cancer. Image guided percutaneous biopsy is an alternative method to obtain histologic material for definitive diagnosis when the biopsies are negative for neoplastic cells in several endoscopies. OBJECTIVE: The purpose of this study was to evaluate the efficacy, complications, and histologic results of image guided percutaneous biopsies of gastric lesions in our center...
December 2009: Acta Gastroenterologica Latinoamericana
A Kant, G Koch, D J Van Roozelaar, F Balk, A T Huurne
Fast diagnosis of Newcastle disease is a prerequisite for confining outbreaks. Diagnosis implies the differentation of virulent and non-virulent Newcastle disease viruses (NDV). However, conventional methods, i.e. isolation of the virus and determination of the intracerebal pathogenicity index, take at least 5 days. Therefore, we investigated whether diagnosis can be performed by using the reverse transcrip-tase-polymerase chain reaction (RT-PCR) on RNA isolated directly from tissue homogenate. Two oligonucleotide primers, representing the sequence at the cleavage site of the F protein of either virulent or non-virulent NDV strains, respectively, were used to differentiate NDV...
1997: Avian Pathology: Journal of the W.V.P.A
Ali Al-Harbi, Ghulam H Malik, Suleiman A Al-Mohaya, Mohammad Akhtar
A 30-year-old seventh gravida presented with acute renal failure at 28 weeks of gestation. All her previous pregnancies were normal. With a differentional diagnosis of acute pyelonephritis, acute interstitial nephritis (cefuroxime induced) or rapidly progressive glomerulonephritis, treatment with antibiotics, intensive hemodialysis (HD) and pulse methylprednisolone followed by oral prednisolone was initiated. She was maintained on HD 5-6 times per week aiming at serum urea level of less than 15 mmol/L. After six weeks on HD, she underwent a cesarean section at 34 weeks of gestation with delivery of a baby weighing 1...
October 2003: Saudi Journal of Kidney Diseases and Transplantation
Murat Oksüz, Yilmaz Ergün, Ulkü Adam, Gülfiliz Gönlüşen, Y Fatih Işiksal, Melek Ergin, Fatin Koçak, Bahri Abayli, Hikmet Akkiz, Ayşe Akman
The case of a 21-yr-old woman admitted with a two-week history of icterus, fever, multiple peripheral lymphadenopathy and pruritic eruption is presented. A full evaluation including computed tomography, endoscopic retrograde cholangiography, liver, skin and lymph node biopsies and biochemical tests confirmed the diagnosis of multicentric Castleman's disease (angiofollicular lymph node hyperplasia). All symptoms improved within four weeks of commencing prednisone therapy. Castleman's disease should be considered in the differental daignosis of cholestatic hepatitis and bullous pemphigoid...
December 2002: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Vm Poblete García, A García Vicente, S Ruíz Solís, C Martínez Delgado, J Vaamonde, S Rodado Marina, M Cortés Romera, Mp Talavera Rubio, R Ibáñez, A Soriano Castrejón
OBJECTIVES: To assess utility of SPECT with 123I-Iolopride ( 123I-IBZM) in the differential diagnosis of patients with Parkinsonian symptoms and try to establish an adequate quantification method. MATERIAL AND METHOD: We analyzed a total of 34 patients who underwent a study with 123I-IBZM SPECT. Studies were analyzed qualitatively (visually) and quantitatively, using different quantification methods. We used different sums of slices (2, 3, 4, and 7 slices) with different cortical regions as a reference (frontal and occipital regions)...
July 2005: Revista Española de Medicina Nuclear
Jie Wang, Lu Jing
It is the key problem of TCM study in the new times to strengthen the research and application of Chinese herbs and its compound prescription directed by TCM theory by combining medicine and drugs, accelerating the creation and construction of modern the new system. In the study of compound, animal mode should be set up by the combination of modern experimental method according to TCM clinical requirements. A breakthrough in compound prescription needs to be found out from observation of pharmacodynamics and analysis of clinical therapy...
September 2003: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
No abstract text is available yet for this article.
May 1963: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
F Siemers, H Ziegler
Mesenteric cysts and cystic lymphangioma are rare intraabdominal lesions. In our clinic, during one year, two young women with these intraabdominal cysts underwent operation because of unspecific abdominal pain. Despite preoperative imaging the final diagnosis of a cystic lymphangioma and a mesenteric chylous cyst was made not before surgery. The postoperative course was uneventful. Problems of diagnostic, differential diagnosis and therapy are presented and differences in etiology, histology and location are discussed...
October 2001: Zentralblatt Für Chirurgie
M Clavio, S Quintino, C Venturino, F Ballerini, R Varaldo, S Gatto, V Galbusera, A Garrone, R Grasso, L Canepa, M Miglino, I Pierri, M Gobbi
Lymphoplasmacytic-lymphoplasmacytoid lymphoma (LPL)/Waldenstrom's macroglobulinemia (WM) or immunocytoma (IMC) consists of diffuse proliferation of small mature B lymphocytes, plasmacytoid lymphocytes, and plasma-cells. The nosographic definition includes the lack of histological, immunophenotypic, cytogenetic, and molecular markers considered specific of other types of lymphoma. The cells show surface Ig (usually IgM), B-cell-associated antigens and display the CD5-, CD23- and CD10- phenotype, which allows for differential diagnosis from B-CLL and mantle cell lymphoma...
September 2001: Journal of Experimental & Clinical Cancer Research: CR
A J Scheen, J C Philips, F H Luyckx, N Paquot, B Jandrain
Owing to the increasing prevalence of diabetes mellitus and the various aspects of this disease, we present a practical approach which allows the clinician to more easily differentiate type 1 diabetes, type 2 diabetes and secondary diabetes of pancreatic origin, i.e. the most common forms of diabetes mellitus. Such an approach uses simple diagnostic criteria, based upon both clinical characteristics (family history, personal history, clinical presentation) and biological markers (C-peptide, autoantibodies,...
September 2001: Revue Médicale de Liège
R M Lawrence
Whilst carrying out a pilot study with a structured questionnaire examining the difference in insight between a group of patients with Alzheimer's Disease and a second group with Vascular Dementia of the Binswanger Type, the incidental observation was made that the group of patients with Vascular Dementia of the Binswanger Type demonstrated more obsessional behaviour than the group of patients with Alzheimer's Disease. The obsessional behaviour differed from classical obsessive compulsive disorder insofar as the subjects were unaware of it whilst at the same time resisting change...
2000: Behavioural Neurology
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