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Bacterial signal transduction

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https://www.readbyqxmd.com/read/28512450/host-plant-compatibility-shapes-the-proteogenome-of-frankia-coriariae
#1
Amir Ktari, Abdellatif Gueddou, Imen Nouioui, Guylaine Miotello, Indrani Sarkar, Faten Ghodhbane-Gtari, Arnab Sen, Jean Armengaud, Maher Gtari
Molecular signaling networks in the actinorhizal rhizosphere select host-compatible Frankia strains, trigger the infection process and eventually the genesis of nitrogen-fixing nodules. The molecular triggers involved remain difficult to ascertain. Root exudates (RE) are highly dynamic substrates that play key roles in establishing the rhizosphere microbiome. RE are known to induce the secretion by rhizobia of Nod factors, polysaccharides, and other proteins in the case of legume symbiosis. Next-generation proteomic approach was here used to decipher the key bacterial signals matching the first-step recognition of host plant stimuli upon treatment of Frankia coriariae strain BMG5...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28512349/the-winding-path-of-protein-methylation-research-milestones-and-new-frontiers
#2
REVIEW
Jernej Murn, Yang Shi
In 1959, while analysing the bacterial flagellar proteins, Ambler and Rees observed an unknown species of amino acid that they eventually identified as methylated lysine. Over half a century later, protein methylation is known to have a regulatory role in many essential cellular processes that range from gene transcription to signal transduction. However, the road to this now burgeoning research field was obstacle-ridden, not least because of the inconspicuous nature of the methyl mark itself. Here, we chronicle the milestone achievements and discuss the future of protein methylation research...
May 17, 2017: Nature Reviews. Molecular Cell Biology
https://www.readbyqxmd.com/read/28508421/subversion-of-host-kinases-a-key-network-in-cellular-signaling-hijacked-by-helicobacter-pylori-caga
#3
REVIEW
Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backert
Helicobacter pylori is a paradigm of persistent pathogens and major risk factor for developing severe diseases including adenocarcinoma in the human stomach. An important bacterial factor linked to gastric disease progression is the cag pathogenicity island-encoded type-IV secretion system (T4SS) effector protein CagA. Translocated CagA undergoes tyrosine phosphorylation at EPIYA-motifs and then activates or inactivates multiple host signaling proteins in a phosphorylation-dependent and phosphorylation-independent fashion...
May 15, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28508135/adaptations-of-archaeal-and-bacterial-membranes-to-variations-in-temperature-ph-and-pressure
#4
REVIEW
Melvin F Siliakus, John van der Oost, Servé W M Kengen
The cytoplasmic membrane of a prokaryotic cell consists of a lipid bilayer or a monolayer that shields the cellular content from the environment. In addition, the membrane contains proteins that are responsible for transport of proteins and metabolites as well as for signalling and energy transduction. Maintenance of the functionality of the membrane during changing environmental conditions relies on the cell's potential to rapidly adjust the lipid composition of its membrane. Despite the fundamental chemical differences between bacterial ester lipids and archaeal ether lipids, both types are functional under a wide range of environmental conditions...
May 15, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28507245/conformational-changes-of-inter-domain-linker-mediate-mechanical-signal-transmission-in-sensor-kinase-bvgs
#5
Elodie Lesne, Elian Dupré, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
The whooping cough agent, Bordetella pertussis, controls the expression of its large virulence regulon in a coordinated manner through the two-component system BvgAS. BvgS is a dimeric, multi-domain sensor-kinase. Each monomer comprises in succession tandem periplasmic Venus flytrap (VFT) domains, a transmembrane segment, a cytoplasmic Per-ArnT-Sim (PAS) domain, a kinase module and additional phosphorelay domains. BvgS shifts between kinase and phosphatase modes of activity in response to chemical modulators that modify the clamshell motions of the VFT domains...
May 15, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28504641/helical-jackknives-control-the-gates-of-the-double-pore-k-uptake-system-ktrab
#6
Marina Diskowski, Ahmad Reza Mehdipour, Dorith Wunnicke, Deryck J Mills, Vedrana Mikusevic, Natalie Bärland, Jan Hoffmann, Nina Morgner, Heinz-Jürgen Steinhoff, Gerhard Hummer, Janet Vonck, Inga Haenelt
Ion channel gating is essential for cellular homeostasis and is tightly controlled. In some eukaryotic and most bacterial ligand-gated K(+) channels, RCK domains regulate ion fluxes. Until now, a single regulatory mechanism has been proposed for all RCK-regulated channels, involving signal transduction from the RCK domain to the gating area. Here we present an inactive ADP-bound structure of KtrAB from Vibrio alginolyticus, determined by cryo-electron microscopy, which, combined with EPR spectroscopy and molecular dynamics simulations, uncovers a novel regulatory mechanism for ligand-induced action at a distance...
May 15, 2017: ELife
https://www.readbyqxmd.com/read/28500346/structural-studies-of-the-periplasmic-portion-of-the-diguanylate-cyclase-cdgh-from-vibrio-cholerae
#7
Min Xu, Yi-Zhi Wang, Xiu-An Yang, Tao Jiang, Wei Xie
Cyclic diguanylate monophosphate (c-di-GMP) is a second messenger involved in bacterial signal transduction and produced by diguanylate cyclases (DGCs) generally containing highly variable periplasmic signal-recognition domains. CdgH is a DGC enzyme that regulates rugosity associated phenotypes in Vibrio cholerae. CdgH has two N-terminal tandem periplasmic substrate-binding (PBPb) domains for its signal recognition; however, the role of the tandem PBPb domains remains unclear. Here, we reported the crystal structure of the periplasmic portion of CdgH, which indicated that both tandem PBPb domains consist of typical interlobe ligand-binding architecture...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500045/sodium-lactate-negatively-regulates-biofilm-formation-of-shewanella-putrefaciens-cn32-via-a-three-component-regulatory-system-lrbs-a-r
#8
Cong Liu, Jinshui Yang, Liang Liu, Baozhen Li, Hongli Yuan, Weijie Liu
The capability of biofilm formation has a major impact on the industrial and biotechnological applications of Shewanella putrefaciens CN32. However, the detailed regulatory mechanisms underlying biofilm formation in S. putrefaciens CN32 remain largely unknown. In the present study, we describe a three-component regulatory system which negatively regulates the biofilm formation of S. putrefaciens CN32. The three-component regulatory system consists of a histidine kinase LrbS (Sputcn32_0303) and two cognate response regulators including a transcription factor LrbA (Sputcn32_0304) and a phosphodiesterase LrbR (Sputcn32_0305)...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28487483/string-method-solution-of-the-gating-pathways-for-a-pentameric-ligand-gated-ion-channel
#9
Bogdan Lev, Samuel Murail, Frédéric Poitevin, Brett A Cromer, Marc Baaden, Marc Delarue, Toby W Allen
Pentameric ligand-gated ion channels control synaptic neurotransmission by converting chemical signals into electrical signals. Agonist binding leads to rapid signal transduction via an allosteric mechanism, where global protein conformational changes open a pore across the nerve cell membrane. We use all-atom molecular dynamics with a swarm-based string method to solve for the minimum free-energy gating pathways of the proton-activated bacterial GLIC channel. We describe stable wetted/open and dewetted/closed states, and uncover conformational changes in the agonist-binding extracellular domain, ion-conducting transmembrane domain, and gating interface that control communication between these domains...
May 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28486170/weak-magnetic-field-a-powerful-strategy-to-enhance-partial-nitrification
#10
Zhibin Wang, Xiaolin Liu, Shou-Qing Ni, Jian Zhang, Xu Zhang, Hafiz Adeel Ahmad, Baoyu Gao
Partial nitrification (PN) combined with anaerobic ammonium oxidation process has been recognized as a promising technology for the removal of nitrogenous contaminants from wastewater. This research aimed to investigate the potential of external magnetic field for enhancing the PN process in short and long term laboratory-scale experiments. Different strength magnetic fields (0, 5, 10, 15, 20 and 25 mT) were evaluated in short-term batch tests and 5 mT magnetic field was found to have better ability to increase the activities of aerobic ammonium oxidizing bacteria (AOB) of PN consortium...
April 26, 2017: Water Research
https://www.readbyqxmd.com/read/28485474/graphene-and-carbon-nanotubes-activate-different-cell-surface-receptors-on-macrophages-before-and-after-deactivation-of-endotoxins
#11
Mohamed H Lahiani, Kuppan Gokulan, Katherine Williams, Mariya V Khodakovskaya, Sangeeta Khare
Nanomaterial synthesis and handling in a non-sterile environment can result in the final product becoming contaminated with bacterial endotoxin or lipopolysaccharides (LPB). During toxicological testing, the effects caused by endotoxin-contaminated nanomaterials can be misinterpreted in the end-point analysis (such as cytotoxicity and immune responses) and could result in erroneous conclusions. The objective of this study was twofold: (i) to test different carbon-based nanomaterials (CBNs) [pristine graphene and multi-wall carbon nanotubes (MWCNTs)] for the presence of endotoxin and develop strategies for depyrogenation, and (ii) to compare the immune response exhibited by macrophages after exposure to native CBNs versus depyrogenated CBNs...
May 9, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28484047/recent-advances-and-future-prospects-in-bacterial-and-archaeal-locomotion-and-signal-transduction
#12
Sonia L Bardy, Ariane Briegel, Simon Rainville, Tino Krell
Unraveling the structure and function of two-component and chemotactic signaling along with different aspects related to motility of bacteria and archaea are key research areas in modern microbiology. Escherichia coli is the traditional model organism to study chemotaxis signaling and motility. However, the recent study of a wide range of bacteria and even some archaea with different lifestyles has provided new insight into the eco-physiology of chemotaxis, which is essential for the host establishment of different pathogens or beneficial bacteria...
May 8, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28484044/class-iii-histidine-kinases-a-recently-accessorized-kinase-domain-in-putative-modulators-of-type-iv-pili-based-motility
#13
Ogun Adebali, Marharyta G Petukh, Alexander O Reznik, Artem V Tishkov, Amit A Upadhyay, Igor B Zhulin
Histidine kinases are key components of regulatory systems that enable bacteria to respond to environmental changes. Two major classes of histidine kinases are recognized on the basis of their modular design: classical (HKI) and chemotaxis-specific (HKII). Recently, a new type of histidine kinases that appeared to have features of both HKI and HKII was identified and termed HKIII; however, the details of HKIII's relationship to other two classes of histidine kinases, their function and evolutionary history remain unknown...
May 8, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28475313/signal-sensing-and-transduction-by-histidine-kinases-as-unveiled-through-studies-on-a-temperature-sensor
#14
Luciano A Abriata, Daniela Albanesi, Matteo Dal Peraro, Diego de Mendoza
Histidine kinases (HK) are the sensory proteins of two-component systems, responsible for a large fraction of bacterial responses to stimuli and environmental changes. Prototypical HKs are membrane-bound proteins that phosphorylate cognate response regulator proteins in the cytoplasm upon signal detection in the membrane or periplasm. HKs stand as potential drug targets but also constitute fascinating systems for studying proteins at work, specifically regarding the chemistry and mechanics of signal detection, transduction through the membrane, and regulation of catalytic outputs...
May 5, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28466033/differential-proteomic-analysis-of-respiratory-samples-from-patients-suffering-from-influenza
#15
Rahul Chavan, Sandeepan Mukherjee, Ritwik Dahake, Domnic Colvin, Avinash Kale, Abhay Chowdhary
The exact molecular pathways involved in the pathogenesis of influenza are yet unclear. In the present study we investigated the upper respiratory proteome in influenza patients. 200 nasal and throat swab samples were collected from patients suffering from acute respiratory illness. These samples were confirmed for influenza pandemic A/H1N1/2009 and influenza type B using qRT-PCR. 10 similar swabs were collected from healthy individuals and were used as controls. Proteins were extracted from the cell pellets and were subjected to 2-D gel electrophoresis...
September 2016: Virusdisease
https://www.readbyqxmd.com/read/28461451/a-novel-two-component-system-glur-k-involved-in-glutamate-sensing-and-uptake-in-streptomyces-coelicolor
#16
Lei Li, Weihong Jiang, Yinhua Lu
Two-component systems (TCSs), the predominant signal transduction pathways employed by bacteria, play important roles in physiological metabolism in Streptomyces Here, a novel TCS GluR-K (encoded by SCO5778-5779), which is located divergently from the gluABCD operon encoding a glutamate uptake system, was identified being involved in glutamate sensing and uptake as well as antibiotic biosynthesis in Streptomyces coelicolor Under the minimal medium (MM) supplemented with different concentrations of glutamate, deletion of gluR-K resulted in enhanced ACT but reduced RED and yCPK production, suggesting GluR-K plays a differential role in antibiotic biosynthesis...
May 1, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28461391/host-serine-threonine-kinases-mtor-and-protein-kinase-c-%C3%AE-promote-inlb-mediated-entry-of-listeria-monocytogenes
#17
Manmeet Bhalla, Daria Law, Georgina C Dowd, Keith Ireton
The bacterial pathogen Listeria monocytogenes causes food-borne illnesses resulting in gastroenteritis, meningitis, or abortion. Listeria induces its internalization into some human cells through interaction of the bacterial surface protein InlB with the host receptor tyrosine kinase Met. InlB-dependent entry requires localized polymerization of the host actin cytoskeleton. Signal transduction pathways that act downstream of Met to regulate actin filament assembly or other processes during Listeria uptake remain incompletely characterized...
May 1, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28459996/the-role-of-p38-mapk-jnk-and-erk-in-antibacterial-responses-of-chilo-suppressalis-lepidoptera-crambidae
#18
Lin Qiu, Boyao Zhang, Lang Liu, Xiaoping Wang, Chaoliang Lei, Yongjun Lin, Jing Zhao, Weihua Ma
The mitogen-activated protein kinases (MAPKs) are conserved signal transduction pathways and broadly responsible for bacterial infection from yeast to mammals, and virus, fungi, and bacteria, specifically Bacillus thuringiensis, to insects. But little is known about the MAPK pathways in antibacterial responses in Chilo suppressalis (Walker), an important lepidopteran pest of rice. In this study, we used the bacteria of Bacillus thuringiensis, Escherichia coli, and Staphyloccocus aureus to infect C. suppressalis larvae, and the responses of MAPK pathways were analyzed...
April 28, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28429713/gating-of-tonb-dependent-transporters-by-substrate-specific-forced-remodelling
#19
Samuel J Hickman, Rachael E M Cooper, Luca Bellucci, Emanuele Paci, David J Brockwell
Membrane proteins play vital roles in inside-out and outside-in signal transduction by responding to inputs that include mechanical stimuli. Mechanical gating may be mediated by the membrane or by protein(s) but evidence for the latter is scarce. Here we use force spectroscopy, protein engineering and bacterial growth assays to investigate the effects of force on complexes formed between TonB and TonB-dependent transporters (TBDT) from Gram-negative bacteria. We confirm the feasibility of protein-only mediated mechanical gating by demonstrating that the interaction between TonB and BtuB (a TBDT) is sufficiently strong under force to create a channel through the TBDT...
April 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28409190/methyl-accepting-chemotaxis-proteins-a-core-sensing-element-in-prokaryotes-and-archaea
#20
REVIEW
Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova
Chemotaxis is the directed motility by means of which microbes sense chemical cues and relocate towards more favorable environments. Methyl-accepting chemotaxis proteins (MCPs) are the most common receptors in bacteria and archaea. They are arranged as trimers of dimers that, in turn, form hexagonal arrays in the cytoplasmic membrane or in the cytoplasm. Several different classes of MCPs have been identified according to their ligand binding region and membrane topology. MCPs have been further classified based on the length and sequence conservation of their cytoplasmic domains...
April 13, 2017: Cellular and Molecular Life Sciences: CMLS
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