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https://www.readbyqxmd.com/read/29676105/-effects-of-tongbi-capsule-on-joint-lesions-in-rabbits-with-rheumatoid-arthritis
#1
Qing-Yong Cao, Pei-Yuan Wang, Qiao-Yun Wang, Feng Zhao, Ke-Zhan Wang, Jun-Qi Liu, Tong-Shen Liu, Yuan-Fang Wang, Yong-Jun Liu
The purpose of this experiment is to observe the effects of Tongbi capsule on joint lesions in rabbit with rheumatoid arthritis induced by ovalbumin and explore the mechanism in order to provide reference for clinical application of Tongbi capsule. Rheumatoid arthritis in rabbits was induced by subcutaneous injection of emulsions of ovalbumin and Freund's complete adjuvant and intra articular injection of ovalbumin. After successful modeling, 30 New Zealand rabbits with arthritis were randomly divided into model control group, the high, medium and low dose groups of Tongbi capsule (90, 45, 22...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675912/tumor-necrosis-factor-%C3%AE-308-g-a-and-interleukin-1-%C3%AE-511-c-t-gene-polymorphisms-in-patients-with-scarring-acne
#2
Gulsen Akoglu, Cagman Tan, Deniz Cagdas Ayvaz, Ilhan Tezcan
BACKGROUND: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 C<T polymorphisms. AIM: To evaluate the association of TNF α-308 and IL-1β-511 gene polymorphisms with acne and postacne scarring susceptibility and acne severity...
April 19, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29674280/the-chemotherapeutic-effect-of-%C3%AE-2-himachalen-6-ol-in-chemically-induced-skin-tumorigenesis
#3
Hamid E Daaboul, Carole Dagher, Robin I Taleb, Kikki Bodman-Smith, Wassim N Shebaby, Mirvat El-Sibai, Mohamad A Mroueh, Costantine F Daher
β-2-himachalen-6-ol (HC), a novel sesquiterpene derived from Lebanese wild carrot, was shown to possess a remarkable anticancer activity. The present study investigates the in vitro anticancer activity of HC and its effect on papillomas induced using a DMBA/TPA skin carcinogenesis mouse model. HaCaT-ras II-4 epidermal squamous cell viability was assessed using WST-1 kit. Cell cycle was analyzed by flow cytometry, and pro/anti-apoptotic proteins were measured using western blot. Mice papillomas were induced by DMBA and promoted with TPA for 18 weeks...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674255/topically-applied-azaphenothiazines-inhibit-experimental-psoriasis-in-mice
#4
Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Iwona Kochanowska, Michał Zimecki, Wojciech Kałas, Anna Fiedorowicz, Alicja Pawlak, Leon Strządała, Małgorzata Jeleń, Beata Morak-Młodawska, Krystian Pluta, Katarzyna Kaleta-Kuratewicz, Jan P Madej, Piotr Kuropka, Jan Kuryszko
The therapeutic efficacy of topically applied azaphenothiazine derivatives: 9-chloro-6-acetylaminobutylquinobenzo[3,2-b][1,4]thiazine (compound 4) and 6-chloroethylureidoethyldiquino[3,2-b;2';3'-e][1,4]thiazine (compound 5) in the amelioration of inflammatory symptoms of imiquimod-induced psoriasis in mice was investigated. Clobederm®, containing clobetasol propioniate, served as a reference drug. The application of the compounds led to thinning of the epidermis and reduction of the cell layers. The suppressive actions of the compounds were even stronger with regard to pathological changes of the dermis...
April 16, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29673080/systemic-sclerosis-and-malignancy
#5
Gokhan Sargin, Taskin Senturk, Songul Cildag
BACKGROUND: Systemic sclerosis (SSc) has increased risk of morbidity and mortality due to pulmonary fibrosis, pulmonary arterial hypertension, renal crisis, infections and malignancies. Chemical exposure, smoking and cytotoxic drugs increase the malignancy risk in rheumatic diseases including SSc. We aim to evaluate characteristics, identify risk factors and mortality in SSc patients with malignancies. METHODS: One hundred and fifty-three patients with SSc (24 male, 129 female, with mean age of 56...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29672809/sapho-and-crmo-the-value-of-imaging
#6
Anne Grethe Jurik, Rikke Fuglsang Klicman, Paolo Simoni, Philip Robinson, James Teh
The syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29671762/increased-level-of-%C3%AE-2-6-sialylated-glycans-on-hacat-cells-induced-by-titanium-dioxide-nanoparticles-under-uv-radiation
#7
Yuanyuan Ren, Xin Liu, Runqing Geng, Qunwei Lu, Rong Rao, Xi Tan, Xiangliang Yang, Wei Liu
As one of the most widely used nanomaterials, the safety of nano-TiO₂ for human beings has raised concern in recent years. Sialylation is an important glycosylation modification that plays a critical role in signal transduction, apoptosis, and tumor metastasis. The aim of this work was to investigate the cytotoxicity and phototoxicity of nano-TiO₂ with different crystalline phases for human skin keratinocytes (HaCaT cells) under ultraviolet (UV) irradiation and detect sialic acid alterations. The results showed that the mixture of crystalline P25 had the highest cytotoxicity and phototoxicity, followed by pure anatase A25, whereas pure rutile R25 had the lowest cytotoxicity and phototoxicity...
April 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29671273/intravital-imaging-of-human-melanoma-cells-in-the-mouse-ear-skin-by-two-photon-excitation-microscopy
#8
Nathan Y Bentolila, Raymond L Barnhill, Claire Lugassy, Laurent A Bentolila
Noninvasive imaging of reporter gene expression by two-photon excitation (2PE) laser scanning microscopy is uniquely suited to perform dynamic and multidimensional imaging down to single-cell detection sensitivity in vivo in deep tissues. Here we used 2PE microscopy to visualize green fluorescent protein (GFP) as a reporter gene in human melanoma cells implanted into the dermis of the mouse ear skin. We first provide a step-by-step methodology to set up a 2PE imaging model of the mouse ear's skin and then apply it for the observation of the primary tumor and its associated vasculature in vivo...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29670374/multiline-treatment-combining-apatinib-with-toptecan-for-platinum-resistant-recurrent-ovarian-cancer-patients-a-report-of-three-cases
#9
Yuan Cheng, Juan Zhang, Haiyun Geng, Shukui Qin, Haiqing Hua
The aim of this study was to observe the efficacy and safety of apatinib combined with toptecan therapy in the multiline treatment of platinum-resistant recurrent ovarian cancer patients. The clinical records of three patients with platinum-resistant recurrent ovarian cancer treated with apatinib combined with toptecan therapy were analyzed and followed up for 3 months, and the related literatures were reviewed. The three patients achieved partial response and the tumor marker CA125 levels decreased significantly as an outcome of the treatment...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29670156/an-automated-skin-segmentation-of-breasts-in-dynamic-contrast-enhanced-magnetic-resonance-imaging
#10
Chia-Yen Lee, Tzu-Fang Chang, Nai-Yun Chang, Yeun-Chung Chang
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to diagnose breast disease. Obtaining anatomical information from DCE-MRI requires the skin be manually removed so that blood vessels and tumors can be clearly observed by physicians and radiologists; this requires considerable manpower and time. We develop an automated skin segmentation algorithm where the surface skin is removed rapidly and correctly. The rough skin area is segmented by the active contour model, and analyzed in segments according to the continuity of the skin thickness for accuracy...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668637/successful-mesenchymal-stem-cell-treatment-of-leg-ulcers-complicated-by-behcet-disease-a-case-report-and-literature-review
#11
Yanhong Li, Zhongming Wang, Yi Zhao, Yubin Luo, Wangdong Xu, Tony N Marion, Yi Liu
RATIONALE: Behçet disease (BD) is a recurrent vasculitis characterized by oral and genital mucous membrane ulcers, uveitis, and skin lesions but only rarely leg ulcers. To our knowledge, no efficacious therapy has been described for BD patients with complicating, destructive leg ulcers. PATIENT CONCERNS: Here, We report the case of a 55-year-old woman with generalized erythema nodosum-like, papulopustular lesions, recurrent oral and genital ulcers accompanied with recurrent leg ulcers and trouble walking...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665210/endoscopic-ultrasound-diagnosis-of-merkel-cell-carcinoma-metastasizing-to-pancreas
#12
Juliana Pinho, Diana Montezuma, Paula Monteiro, Mário Dinis-Ribeiro, Pedro Bastos
Merkel cell carcinoma (MCC) is a rare and aggressive primary neuroendocrine tumor of the skin, with a high propensity for local, regional and distant spread1 . However, distant metastasis of MCC to the pancreas are rarely seen. EUS-FNA is an effective tool in the evaluation and differential diagnosis of pancreatic mass lesions3 . Differentiating metastatic pancreatic tumors, especially Merkel cell carcinoma, from primary pancreatic tumor will influence clinical management and therapeutic strategies2 . This article is protected by copyright...
April 17, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29665032/testicular-choriocarcinoma-with-cutaneous-metastasis-in-a-19-year-old-man
#13
Ferdinand Toberer, Alexander Enk, Wolfgang Hartschuh, Carsten Grüllich
A 19-year-old man suffering from testicular choriocarcinoma presented to the dermatology department with a cutaneous metastasis on his head. This metastasis was the first sign of disease that led to medical consultation. Histopathology revealed cytotrophoblasts and syncytiotrophoblasts, the later expressing human chorionic gonadotropin antigen. Whole body computed tomography showed multiple metastases of the brain, lung, liver, bone, paraaortic lymph nodes and left uvea, the primary was found in the left testicle...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29665030/dermatologic-toxicity-from-novel-therapy-using-antimicrobial-peptide-ll-37-in-melanoma-a-detailed-examination-of-the-clinicopathologic-features
#14
Tsetan Dolkar, Celestine M Trinidad, Kelly C Nelson, Rodabe N Amaria, Priyadharsini Nagarajan, Carlos A Torres-Cabala, Doina Ivan, Victor G Prieto, Michael T Tetzlaff, Jonathan L Curry, Phyu P Aung
LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. We report dermatologic toxicity in a 63-year-old woman with stage IIIC melanoma of the right calf and inguinal lymph nodes...
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29664210/differential-clinical-presentation-of-adamantiades-beh%C3%A3-et-s-disease-in-non-endemic-and-endemic-areas-retrospective-data-from-a-middle-european-cohort-study
#15
Thomas Moosmann, Cécilia Veraar, Jürgen Brunner, Gustav Fraedrich, Andreas Frech, Wolfgang Horninger, Gudrun Ratzinger, Werner Streif, Barbara Teuchner, Johann Willeit, Manuela Zlamy, Tobias De Zordo, Michael Schirmer
OBJECTIVES: To assess demographical and clinical data in a Middle-European cohort of patients with Adamantiades-Behçet's disease (ABD), together with the use of medication in adherence to international guidelines. METHODS: In a retrospective cohort study, in- and outpatients of an Austrian secondary and tertiary university hospital center were analyzed independent from the medical discipline involved. After ethics approval, screening for ABD-patients in the clinical information system resulted in 1821 documents from 1997 to 2016...
April 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29663929/generation-of-a-graft-versus-anticancer-immune-response-through-skin-allograft-with-tumor
#16
Yuan Fang, Sufang Zhou, Baoshi Zheng, Wenlin Gong, Yong Huang, Zhenghua Zhang, Chaofan Zhou, Huiling Wang, Zhimei Huang, Liping Zhong, Yongxiang Zhao
Effector memory T cells (TEM) are a subset of memory T cells which play an important role in stimulation of adaptive immunity. Although they are associated with multiple immune responses, the antitumor effect of TEM is not clearly understood. In this research, generation of anti-tumor TEM was induced through skin allografts in C57BL/6 mice with B16 melanoma. We observed that the growth of tumor tissues in C57BL/6 mice treated with allografts was interrupted. Furthermore, the survival time for the treated mice was prolonged along with increased serum levels for CXCL9, CXCL10 and INF-γ...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663367/gadd45a-gene-silencing-by-rnai-promotes-cell-proliferation-and-inhibits-apoptosis-and-senescence-in-skin-squamous-cell-carcinoma-through-the-p53-signaling-pathway
#17
Li-Qian Liu, Fu-Jun Tian, Ying Xiong, Yan Zhao, Jian-Bo Song
Skin squamous cell carcinoma (SCC) is generally considered as nonaggressive lesions and mainly caused by ultraviolet (UV) radiation. Gadd45a is a key component protecting skin against UV-induced tumors. For that, the study aims to investigate the mechanism of Gadd45a gene silencing on cell proliferation, apoptosis, and senescence in nude mice with skin SCC through the p53 signaling pathway. Healthy nude mice was collected as the normal group and 40 nude mouse models of skin SCC were successfully established as the model group, which were sub-divided into five groups...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29661476/cutaneous-presentation-of-adult-t-cell-leukemia-lymphoma-atll-single-center-study-on-37-patients-in-metropolitan-france-between-1996-and-2016
#18
C Hurabielle, M Battistella, C Ram-Wolff, C Fite, V Meignin, J Rivet, M-D Vignon-Pennamen, T de Risi-Pugliese, E Raffoux, B Arnulf, E Oksenhendler, F Sicre de Fontbrune, R Peffault de Latour, G Socié, J-D Bouaziz, C Lebbé, A Bensussan, M Bagot
INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a hematological malignancy associated with chronic HTLV-1 infection. AIM: To describe skin lesions in ATLL. METHODS: A descriptive, retrospective study between 1996 and 2016, including all patients diagnosed with ATLL at Saint-Louis Hospital (Paris, France). RESULTS: Thirty-seven ATLL patients were included. Fifteen patients (41%) had a cutaneous localization of the disease, which was present from the beginning of the disease for two thirds of them...
April 13, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29661336/cutaneous-head-and-neck-malignancies-in-the-elderly
#19
REVIEW
Brian B Hughley, Cecelia E Schmalbach
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29661274/granular-cell-tumor-experience-at-a-comprehensive-cancer-center
#20
Ambria S Moten, Sujana Movva, Margaret von Mehren, Hong Wu, Nestor F Esnaola, Sanjay S Reddy, Jeffrey M Farma
BACKGROUND: Granular cell tumors (GCTs) are rare lesions occurring almost anywhere in the body. Multiple case reports have been published. However, there are very few large-scale studies regarding GCT. The aim of this study was to define characteristics, treatment patterns and outcomes of patients with GCT. METHODS: An institutional review board-approved retrospective chart review was performed. Descriptive statistics, chi-square analyses, and Kaplan-Meier survival estimates were produced...
June 2018: Journal of Surgical Research
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