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https://www.readbyqxmd.com/read/29221181/analysis-of-ctcl-cell-lines-reveals-important-differences-between-mycosis-fungoides-s%C3%A3-zary-syndrome-vs-htlv-1-leukemic-cell-lines
#1
Elena Netchiporouk, Jennifer Gantchev, Matthew Tsang, Philippe Thibault, Andrew K Watters, John-Douglas Matthew Hughes, Feras M Ghazawi, Anders Woetmann, Niels Ødum, Denis Sasseville, Ivan V Litvinov
HTLV-1 is estimated to affect ~20 million people worldwide and in ~5% of carriers it produces Adult T-Cell Leukemia/Lymphoma (ATLL), which can often masquerade and present with classic erythematous pruritic patches and plaques that are typically seen in Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most recognized variants of Cutaneous T-Cell Lymphomas (CTCL). For many years the role of HTLV-1 in the pathogenesis of MF/SS has been hotly debated. In this study we analyzed CTCL vs. HTLV-1+ leukemic cells...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29220390/maldi-msi-of-melim-melanoma-searching-for-differences-in-protein-profiles
#2
Roman Guran, Lucie Vanickova, Vratislav Horak, Sona Krizkova, Petr Michalek, Zbynek Heger, Ondrej Zitka, Vojtech Adam
BACKGROUND: Treatment of advanced cutaneous melanoma remains challenging, and new data on melanoma biology are required. The most widely accepted criteria for the prognostic evaluation of melanoma are histopathological and clinical parameters, and the identification of additional tumor markers is thus of paramount importance. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI), an important tool in cancer research, is useful for unraveling the molecular profile of melanoma...
2017: PloS One
https://www.readbyqxmd.com/read/29218279/non-metastatic-non-melanoma-skin-cancers-our-3-years-of-clinical-experiences
#3
Elif Sari
BACKGROUND: Nonmelanoma skin cancers (NMSC) constitute the largest group of skin cancers. In this study, NMSCs were analyzed retrospectively. METHODS: Between June 2013 and March 2017, demographics and comorbidities of patients underwent reconstructive surgery for NMSC; their risk factors, types, diameters, differentiation, localizations, follow-up times, treatment methods and complications were compared and statistically analyzed. RESULTS: Totally, 163 tumors [111 basal cell carcinoma and 52 cutaneous squamous cell carcinoma (cSCC)] were excized from 148 patients (63 females, 85 males)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29215016/low-neurotrophin-receptor-cd271-regulates-phenotype-switching-in-melanoma
#4
Gaetana Restivo, Johanna Diener, Phil F Cheng, Gregor Kiowski, Mario Bonalli, Thomas Biedermann, Ernst Reichmann, Mitchell P Levesque, Reinhard Dummer, Lukas Sommer
Cutaneous melanoma represents the most fatal skin cancer due to its high metastatic capacity. According to the "phenotype switching" model, the aggressive nature of melanoma cells results from their intrinsic potential to dynamically switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state. Here we identify the low affinity neurotrophin receptor CD271 as a key effector of phenotype switching in melanoma. CD271 plays a dual role in this process by decreasing proliferation, while simultaneously promoting invasiveness...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29214089/systemic-treatment-of-metastatic-conjunctival-melanoma
#5
Simão Pinto Torres, Teresa André, Emanuel Gouveia, Lívio Costa, Maria José Passos
Conjunctival melanoma (CM) is an exceptionally rare tumor, with a propensity for local and distant recurrence, with the lungs, skin, liver, and brain being the most common sites of metastasis. Recent progress in systemic treatments, with checkpoint inhibitors and targeted therapies blocking BRAF and MEK, has redefined the standard of care of advanced unresectable and metastatic melanoma. Although most trials did not include patients with conjunctival melanoma, its close molecular and genetic relationship to cutaneous melanoma might suggest a similar response to these novel agents...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#6
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29209797/-morphology-of-non-cutaneous-head-and-neck-squamous-cell-carcinoma
#7
REVIEW
W Weichert, S Ihrler, M Boxberg, A Agaimy, M Mollenhauer, A Hartmann
Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. The morphology of HNSCC comprises a spectrum of growth patterns...
December 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29205926/a-retrospective-review-of-the-persistence-on-bdmards-prescribed-for-the-treatment-of-rheumatoid-arthritis-in-the-australian-population
#8
Graeme Jones, Stephen Hall, Paul Bird, Geoff Littlejohn, Kathleen Tymms, Peter Youssef, Eric Chung, Rina Barrett, Peter Button
AIM: To describe the persistence of biologic disease modifying anti-rheumatic drugs (bDMARDs) in Australian rheumatoid arthritis (RA) patients, and assess the influence of methotrexate and other conventional DMARD (cDMARD) concomitant medications, and treatment line on bDMARD persistence and glucocorticoids usage. METHOD: RA patients, from the 10% Australian Medicare random sample, aged ≥18 for whom bDMARDs were dispensed were included. Individual sub-cutaneous (SC) anti-tumor necrosis factor-α (anti-TNFα) agents were combined as they were equivalent...
December 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29205457/primary-cutaneous-secretory-carcinoma-a-previously-overlooked-low-grade-sweat-gland-carcinoma
#9
M Llamas-Velasco, T Mentzel, A Rütten
Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published; nine of them showed the ETV6-NTRK3 translocation and an additional case had a heterozygous deletion of ETV6 in 25% of cells (Table 1).1-7 These cutaneous tumors are related to secretory breast carcinoma (SBC) and mammary analogue secretory carcinoma (MASC) from the salivary glands, with all sharing a balanced chromosomal translocation of t(12;15)(p13;q25) that leads to ETV6-NTRK3 gene fusion.
December 4, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29204254/gastric-metastasis-from-ovarian-adenocarcinoma-presenting-as-a-subepithelial-tumor-and-diagnosed-by-endoscopic-ultrasound-guided-tissue-acquisition
#10
Filippo Antonini, Liboria Laterza, Lorenzo Fuccio, Massimo Marcellini, Lucia Angelelli, Sonia Calcina, Corrado Rubini, Giampiero Macarri
We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor (SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy (EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features...
November 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29204144/all-trans-retinoic-acid-promotes-an-m1-to-m2-phenotype-shift-and-inhibits-macrophage-mediated-immunity-to-leishmania-major
#11
Natália S Vellozo, Sâmara T Pereira-Marques, Mariela P Cabral-Piccin, Alessandra A Filardy, Flávia L Ribeiro-Gomes, Thaís S Rigoni, George A DosReis, Marcela F Lopes
As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis. Macrophage phenotypes range from M1, which express NO-mediated microbial killing, to M2 macrophages that might help infection. Resistance to Leishmaniasis depends on Leishmania species, mouse strain, and both innate and adaptive immunity. C57BL/6 (B6) mice are resistant and control infection, whereas Leishmania parasites thrive in BALB/c mice, which are susceptible to develop cutaneous lesions in the course of infection with Leishmania major, but not upon infection with Leishmania braziliensis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29202490/-metastasation-of-cutaneous-squamous-cell-carcinoma-in-the-ent-area
#12
Alexander Dellweg, Thomas Mantei
Objectives Our aim was to investigate the metastasis behavior and its prognostic Factor for Survival, with our clinical data. Materials and methods This retrospective study included 29 Caucasians, with a squamous cell carcinoma of the skin in the head and neck region, at our tertiary clinic between 2004 and 2016. All Patients received a Tumorresection and Neckdissection. We used either Ultrasound or Computer-Tomography (conventional or PET-CT) for our preoperative Staging and the Follow-up. The Patients were classified according to metastatic behavior and the corresponding survival rates were determined...
December 4, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29200771/syringoid-eccrine-carcinoma-of-the-thigh
#13
Yong-Yon Won, Dong-Woo Suh, Bark-Lynn Lew, Woo-Young Sim
Syringoid eccrine carcinoma (SEC) is a rare cutaneous malignant tumor thought to be derived from eccrine sweat apparatus. It is usually present in the head, neck and trunk region, and often occurs in the fourth to seventh decades of life. A 94-year-old male patient visited our department with an 80-year history of a lesion showing a 2×2 cm sized well-demarcated round shaped erythematous to pinkish colored nodule with ulcer on his left thigh. Histological findings revealed a tumor consisted mainly of numerous small cords and nests forming luminal or tubular structures and tumor cells showing variable atypia...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29194742/highly-variable-clinical-feature-and-course-of-aggressive-digital-papillary-adenocarcinoma
#14
Kenji Yokota, Michihiro Kono, Kazue Shimizu, Akihiro Sakakibara, Masashi Akiyama
Aggressive digital papillary adenocarcinoma (ADPA) is a rare cutaneous tumor with sweat gland differentiation. Due to the high risk of local recurrence and delayed metastasis, the wide local resection of the primary lesion and long-term follow up are recommended for ADPA. Here, we report two cases of ADPA. Case 1 had a blue-gray nodule on the tip of the right middle finger. Case 2 had had a papule on the dorsal side of the left ring finger for 13 years. In both cases, papillary proliferations of the tumor cells showed multilobular adenomatous structures with back-to-back patterns characteristic of ADPA...
November 30, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29192135/encephalocraniocutaneous-lipomatosis-haberland-syndrome
#15
Selçuk Özdoğan, Ceyhun Saymaz, Cumhur Kaan Yaltırık, Hanife Gülden Düzkalır, Mustafa Kaya, Nail Demirel, Ali Haluk Düzkalır, Başar Sarıkaya, Berrin Aktekin
BACKGROUND Encephalocraniocutaneous lipomatosis (ECCL) was first announced as a new type of ectomesodermal dysgenesis in 1970 by Haberland and Perou. ECCL was first described in 1970, and approximately 60 cases have been reported since then. The classic triad of ECCL are skin, ocular, and central nervous system involvement, including conditions such as unilateral porencephalic cyst, ipsilateral lipomatous hamartoma of the scalp-eyelids-eye globe, cortical atrophy, cranial asymmetry, developmental delay, seizures, mental retardation, and spasticity of the contralateral limbs...
December 1, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29191916/duvelisib-a-novel-oral-dual-inhibitor-of-pi3k-%C3%AE-%C3%AE-is-clinically-active-in-advanced-hematologic-malignancies
#16
Ian W Flinn, Susan O'Brien, Brad Kahl, Manish Patel, Yasuhiro Oki, Francine F Foss, Pierluigi Porcu, Jeffrey Jones, Jan A Burger, Nitin Jain, Virginia M Kelly, Kerstin Allen, Mark Douglas, Jennifer Sweeney, Patrick Kelly, Steven Horwitz
Duvelisib (IPI-145) is a novel, oral, dual inhibitor of phosphoinositide 3-kinase (PI3K)-δ and PI3K-γ in late-stage clinical development for treatment of hematologic malignancies. This Phase 1 study (registered as NCT01476657 at ClinicalTrials.gov) evaluated the maximum tolerated dose (MTD), pharmacokinetics (PK), pharmacodynamics (PD), efficacy, and safety of duvelisib in 210 patients with advanced hematologic malignancies. In the Dose Escalation Phase (n=31), duvelisib 8 to 100 mg BID was administered, with MTD determined to be 75 mg BID...
November 30, 2017: Blood
https://www.readbyqxmd.com/read/29190285/the-interplay-of-uv-and-cutaneous-papillomavirus-infection-in-skin-cancer-development
#17
Daniel Hasche, Sonja Stephan, Ilona Braspenning-Wesch, Julita Mikulec, Martina Niebler, Hermann-Josef Gröne, Christa Flechtenmacher, Baki Akgül, Frank Rösl, Sabrina E Vinzón
Cutaneous human papillomaviruses (HPVs) are considered as cofactors for non-melanoma skin cancer (NMSC) development, especially in association with UVB. Extensively studied transgenic mouse models failed to mimic all aspects of virus-host interactions starting from primary infection to the appearance of a tumor. Using the natural model Mastomys coucha, which reflects the human situation in many aspects, we provide the first evidence that only UVB and Mastomys natalensis papillomavirus (MnPV) infection strongly promote NMSC formation...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29185769/a-drug-repurposing-approach-identifies-a-synergistic-drug-combination-of-an-antifungal-agent-and-an-experimental-organometallic-drug-for-melanoma-treatment
#18
Tina Riedel, Olivier Demaria, Olivier Zava, Ana Joncic, Michel Gilliet, Paul J Dyson
By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent Haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of these two small molecules, even at low doses, elicited an improved therapeutic response on tumor growth over either agent alone or the current treatment used in the clinic in the highly aggressive syngeneic B16F10 melanoma tumor model, where classical cytotoxic chemotherapeutic agents show little efficacy...
November 29, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29185395/pd-l1-expression-in-tumor-metastasis-is-different-between-uveal-melanoma-and-cutaneous-melanoma
#19
Asad Javed, David Arguello, Curtis Johnston, Zoran Gatalica, Mizue Terai, Ryan M Weight, Marlana Orloff, Michael J Mastrangelo, Takami Sato
AIM: To compare PD-L1 expression between metastatic uveal melanoma (MUM) and metastatic cutaneous melanoma (MCM). MATERIALS & METHODS: A total of 295 MCM and 78 MUM specimens were analyzed for tumor cell PD-L1 expression. Additionally, 91 MCM and 45 MUM specimens were analyzed for PD-1 expression on tumor-infiltrating lymphocytes. RESULTS:  A total of 77/295 (26.1%) MCM specimens expressed PD-L1 as compared to 4/78 (5.1%) MUM specimens (p < 0...
December 2017: Immunotherapy
https://www.readbyqxmd.com/read/29184882/cutaneous-metastasis-a-rare-phenomenon-of-colorectal-cancer
#20
Dan Yang Wang, Feng Ye, Jian Jiang Lin, Xiao Xu
Cutaneous metastases from colorectal cancer are extremely rare and generally appear several years after diagnosis or resection of the primary tumor. Although this phenomenon is uncommon, it is very important and often indicates a poor prognosis. We present a case of a 76-year-old female patient with multiple cutaneous metastatic nodules on the back, just 1 month after resection of rectal cancer. Unfortunately, the patient gave up the follow-up treatment due to her age and poor physical condition; she died 3 months later...
November 2017: Annals of Surgical Treatment and Research
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