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https://www.readbyqxmd.com/read/28088077/rhoa-knockdown-by-cationic-amphiphilic-copolymer-sirhoa-polyplexes-enhances-axonal-regeneration-in-rat-spinal-cord-injury-model
#1
So-Jung Gwak, Christian Macks, Da Un Jeong, Mark Kindy, Michael Lynn, Ken Webb, Jeoung Soo Lee
Spinal cord injury (SCI) results in permanent loss of motor and sensory function due to developmentally-related and injured-induced changes in the extrinsic microenvironment and intrinsic neuronal biochemistry that limit plasticity and axonal regeneration. Our long term goal is to develop cationic, amphiphilic copolymers (poly (lactide-co-glycolide)-g-polyethylenimine, PgP) for combinatorial delivery of therapeutic nucleic acids (TNAs) and drugs targeting these different barriers. In this study, we evaluated the ability of PgP to deliver siRNA targeting RhoA, a critical signaling pathway activated by multiple extracellular inhibitors of axonal regeneration...
January 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28087372/the-future-of-artificial-intelligence-and-interpretative-specialization-in-clinical-biochemistry
#2
Christopher McCudden
No abstract text is available yet for this article.
January 10, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28081171/a-higher-proportion-of-metabolic-syndrome-in-chinese-subjects-with-sleep-disordered-breathing-a-case-control-study-based-on-electrocardiogram-derived-sleep-analysis
#3
Ping-Huei Tseng, Pei-Lin Lee, Wei-Chung Hsu, Yan Ma, Yi-Chia Lee, Han-Mo Chiu, Yi-Lwun Ho, Ming-Fong Chen, Ming-Shiang Wu, Chung-Kang Peng
OBJECTIVE: The prevalence of metabolic syndrome (MS) has increased rapidly in Taiwan and worldwide. We aim to determine the association between sleep-disordered breathing (SDB) and MS in a Chinese general population. METHODS: This case-control study recruited subjects who have undergone a prospective electrocardiogram-based cardiopulmonary coupling (CPC) sleep spectrogram as part of the periodic health check-ups at the National Taiwan University Hospital. Comprehensive anthropometrics, blood biochemistry, prevalence of MS and its individual components were compared with Bonferroni correction between 40 subjects with SDB, defined as the CPC-derived apnea-hypopnea index (CPC-AHI) >5 event/hour and 80 age- and sex-matched controls, defined as CPC-AHI <1 event/hour...
2017: PloS One
https://www.readbyqxmd.com/read/28080925/cardiac-assessment-of-zoo-kept-black-tailed-prairie-dogs-cynomys-ludovicianus-anesthetized-with-isoflurane
#4
Eric B Garcia, David Eshar, Justin D Thomason, Kenneth R Harkin, David Biller
Cardiomyopathy is suggested to be a relatively common disease condition in prairie dogs; however, there are no reports of normal cardiac echosonography and radiology in the prairie dog ( Cynomys spp.). The objective of this study was to report the ultrasonographic and radiographic measurements of the heart, and plasma troponin concentration in captive healthy anesthetized black-tailed prairie dogs ( Cynomys ludovicianus ). Zoo-kept prairie dogs with no signs of cardiac disease (n = 17) were evaluated. Each animal was anesthetized with isoflurane via face mask and a complete clinical assessment was performed, including complete blood cell count and plasma biochemistry, urinalysis, blood gasses, plasma troponin concentration, three-view whole body radiography, and echocardiogram...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28080924/selected-plasma-biochemistry-analytes-of-healthy-captive-sulcata-african-spurred-tortoises-centrochelys-sulcata
#5
David Eshar, Ady Y Gancz, Nili Avni-Magen, Effi Wagshal, Lisa M Pohlman, Mark A Mitchell
The sulcata or African spurred tortoise (Centrochelys sulcata) is a large tortoise species that is commonly kept in zoologic collections and as a pet. The objectives of this study were to establish reference intervals for selected biochemical analytes in clinically healthy captive sulcata tortoises and to evaluate the impact of blood sampling site and sex. Blood samples were collected from 60 tortoises from either the dorsal coccygeal (tail) vein or the subcarapacial venous plexus based on their body size. The packed cell volume and refractometric total solids (TS) were determined...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28080899/health-and-nutritional-assessment-of-free-ranging-eastern-indigo-snakes-drymarchon-couperi-in-georgia-united-states
#6
S Emmanuelle Knafo, Terry M Norton, Mark Mitchell, Dirk J Stevenson, Natalie Hyslop, Robert Poppenga, Marcie Oliva, Tai Chen, Carolyn Cray, Samantha E J Gibbs, Lance Durden, Nancy Stedman, Stephen Divers, Ellen Dierenfeld
Clinical pathology and nutritional parameters are useful in evaluating and monitoring threatened and endangered wildlife populations, but reference ranges for most snake species are lacking. From 2001 to 2005, health assessments were performed on 58 eastern indigo snakes (EIS) (Drymarchon couperi) captured in the wild in southeastern Georgia, United States. Health and nutritional assessments performed included hematology, serum biochemistry, fat-soluble vitamins, heavy metals, pesticide contaminants, parasitology, and surveys of other pathogens...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28080896/traumatic-foreign-body-pericarditis-in-a-toco-toucan-ramphastos-toco
#7
Mireia Máinez, Jorge Rosell, Roger Such, Teresa Cardona, Carles Juan-Sallés
An approximately 10-yr-old, captive-born female toco toucan ( Ramphastos toco ) was presented due to an acute onset of depression and apathy. On visual and physical examination, it showed an abnormal posture and dehydration, respectively. Serum biochemistry revealed hyperuricemia (39.4 mg/dl) and elevated glutamic oxaloacetic transaminase (GOT; 1,050 U/L). Radiographs demonstrated an enlargement of the cardiac silhouette. The bird died 7 days after presentation, despite treatment with enrofloxacin, allopurinol, a preparation of hepatorenal protectors, and complex B vitamins with dextrose...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28080221/molecular-mechanisms-of-antisense-oligonucleotides
#8
Stanley T Crooke
In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems. Since 1989, my research has focused primarily on this topic, although I have been involved in most areas of research in antisense technology. I believe that the art of excellent science is to frame large important questions that are perhaps not immediately answerable with existing knowledge and methods, and then conceive a long-term (multiyear) research strategy that begins by answering the most pressing answerable questions on the path to the long-term goals...
January 12, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28080034/the-mechanism-of-the-flavoprotein-6-hydroxy-l-nicotine-oxidase-ph-and-solvent-isotope-effects-and-identification-of-key-active-site-residues
#9
Paul F Fitzpatrick, Fatemeh Chadegani, Shengnan Zhang, Vi Dougherty
The flavoenzyme L-6-hydroxynicotine oxidase (LHNO) is a member of the monoamine oxidase family that catalyzes the oxidation of (S)-6-hydroxynicotine to 6-hydroxypseudooxynicotine during microbial catabolism of nicotine. While the enzyme has long been understood to catalyze oxidation of carbon-carbon bond, it has recently been shown to catalyze oxidation of a carbon-nitrogen bond (Fitzpatrick et al., Biochemistry 55, 697-703). The effects of pH and mutagenesis of active site residues have now been utilized to study the mechanism and the roles of active site residues...
January 12, 2017: Biochemistry
https://www.readbyqxmd.com/read/28077563/the-bioc-biogrid-corpus-full-text-articles-annotated-for-curation-of-protein-protein-and-genetic-interactions
#10
Rezarta Islamaj Doğan, Sun Kim, Andrew Chatr-Aryamontri, Christie S Chang, Rose Oughtred, Jennifer Rust, W John Wilbur, Donald C Comeau, Kara Dolinski, Mike Tyers
A great deal of information on the molecular genetics and biochemistry of model organisms has been reported in the scientific literature. However, this data is typically described in free text form and is not readily amenable to computational analyses. To this end, the BioGRID database systematically curates the biomedical literature for genetic and protein interaction data. This data is provided in a standardized computationally tractable format and includes structured annotation of experimental evidence. BioGRID curation necessarily involves substantial human effort by expert curators who must read each publication to extract the relevant information...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28073471/biochemistry-and-genetics-of-taste-and-odor-producing-cyanobacteria
#11
REVIEW
Susan B Watson, Paul Monis, Peter Baker, Steven Giglio
Cyanobacteria are one of the principal sources of volatile organic compounds (VOCs) which cause offensive taste and odor (T&O) in drinking and recreational water, fish, shellfish and other seafood. Although non-toxic to humans, these T&O compounds severely undermine public trust in these commodities, resulting in substantial costs in treatment, and lost revenue to drinking water, aquaculture, food and beverage and tourist/hospitality industries. Mitigation and control have been hindered by the complexity of the communities and processes which produce and modify T&O events, making it difficult to source-track the major producer(s) and the factors governing VOC production and fate...
April 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072692/role-of-biochemistry-and-cytological-analysis-of-cyst-fluid-for-the-differential-diagnosis-of-pancreatic-cysts-a-retrospective-cohort-study
#12
Ozlem Mutluay Soyer, Bulent Baran, Asli Ciftcibasi Ormeci, Davut Sahin, Suut Gokturk, Sami Evirgen, Rafet Basar, Pinar Firat, Filiz Akyuz, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu, Cetin Karaca
BACKGROUND: Management of pancreatic cysts is based on neoplastic-nonneoplastic discrimination. Endoscopic ultrasound (EUS) enables to differentiate neoplastic-nonneoplastic lesions and also allows fine-needle aspiration (FNA). In this study, we aim to assess feasibility and clinical relevance of cytological and biochemical analysis in differential diagnosis of cystic pancreatic lesions in patients who had undergone endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) due to pancreatic cysts...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071669/use-of-fibonacci-numbers-in-lipidomics-enumerating-various-classes-of-fatty-acids
#13
Stefan Schuster, Maximilian Fichtner, Severin Sasso
In lipid biochemistry, a fundamental question is how the potential number of fatty acids increases with their chain length. Here, we show that it grows according to the famous Fibonacci numbers when cis/trans isomerism is neglected. Since the ratio of two consecutive Fibonacci numbers tends to the Golden section, 1.618, organisms can increase fatty acid variability approximately by that factor per carbon atom invested. Moreover, we show that, under consideration of cis/trans isomerism and/or of modification by hydroxy and/or oxo groups, diversity can be described by generalized Fibonacci numbers (e...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28068985/enzymatic-process-optimization-for-the-in-vitro-production-of-isoprene-from-mevalonate
#14
Tao Cheng, Hui Liu, Huibin Zou, Ningning Chen, Mengxun Shi, Congxia Xie, Guang Zhao, Mo Xian
BACKGROUND: As an important bulk chemical for synthetic rubber, isoprene can be biosynthesized by robust microbes. But rational engineering and optimization are often demanded to make the in vivo process feasible due to the complexities of cellular metabolism. Alternative synthetic biochemistry strategies are in fast development to produce isoprene or isoprenoids in vitro. RESULTS: This study set up an in vitro enzyme synthetic chemistry process using 5 enzymes in the lower mevalonate pathway to produce isoprene from mevalonate...
January 9, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28068065/sustained-nitric-oxide-release-from-a-tertiary-s-nitrosothiol-based-polyphosphazene-coating
#15
Alec Lutzke, Jesus B Tapia, Megan J Neufeld, Melissa M Reynolds
Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing properties. NO-forming biodegradable polymers have been utilized in the development of antithrombotic or antibacterial materials for biointerfacial applications, including tissue engineering and the fabrication of erodible coatings for medical devices such as stents. Use of such NO-forming polymers has frequently been constrained by short-term release or limited NO storage capacity and has led to the pursuit of new materials with improved NO release function...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28068053/surface-modification-of-gold-nanoparticles-with-small-molecules-for-biochemical-analysis
#16
Yiping Chen, Yunlei Xianyu, Xingyu Jiang
As one of the major tools for and by chemical science, biochemical analysis is becoming increasingly important in fields like clinical diagnosis, food safety, environmental monitoring, and the development of chemistry and biochemistry. The advancement of nanotechnology boosts the development of analytical chemistry, particularly the nanoparticle (NP)-based approaches for biochemical assays. Functional NPs can greatly improve the performance of biochemical analysis because they can accelerate signal transduction, enhance the signal intensity, and enable convenient signal readout due to their unique physical and chemical properties...
January 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28067962/concurrent-multiple-myeloma-and-mast-cell-neoplasia-in-a-13-year-old-castrated-male-maine-coon-cat
#17
Jonathan M Bagwell, Heather R Herd, Melanie A Breshears, Steven Hodges, Theresa E Rizzi
A 13-year-old, castrated male Maine Coon cat was presented to Oklahoma State University Boren Veterinary Medical Teaching Hospital for yearly echocardiographic examination monitoring hypertrophic cardiomyopathy (HCM) diagnosed in 2003. Physical examination revealed a heart murmur and premature beats, likely related to HCM, but was otherwise unremarkable. A biochemistry profile revealed a hyperglobulinemia (6.3 g/dL). Cytologic examination of fine-needle aspirates from liver and spleen revealed increased numbers of plasma cells and mast cells, confirmed with subsequent histologic examination...
January 9, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28065759/a-subchronic-90-day-oral-toxicity-study-of-origanum-vulgare-essential-oil-in-rats
#18
M Llana-Ruiz-Cabello, S Maisanaba, M Puerto, S Pichardo, A Jos, R Moyano, A M Cameán
Oregano essential oil (Origanum vulgare L. virens) (OEO) is being used in the food industry due to its useful properties to develop new active packaging systems. In this concern, the safety assessment of this natural extract is of great interest before being commercialized. The European Food Safety Authority requests different in vivo assays to ensure the safety of food contact materials. One of these studies is a 90 days repeated-dose oral assay in rodents. In the present work, 40 male and 40 female Wistar rats were orally exposed to 50, 100 and 200 mg/kg body weight (b...
January 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28065395/serial-retrograde-instillations-of-sustained-release-formulation-of-mitomycin-c-to-the-upper-urinary-tract-of-the-yorkshire-swine-using-a-thermosensitive-polymer-safety-and-feasibility
#19
Nicholas M Donin, Dalit Strauss-Ayali, Yael Agmon-Gerstein, Nadav Malchi, Andrew T Lenis, Stuart Holden, Allan J Pantuck, Arie S Belldegrun, Karim Chamie
BACKGROUND: MitoGel is a novel drug formulation intended for the treatment of upper tract urothelial cancer with proven feasibility and safety in an animal model. OBJECTIVE: To evaluate the feasibility, safety, toxicokinetics, and histologic changes associated with serial retrograde MitoGel instillations to the upper urinary tract in a swine model. DESIGN, SETTING, AND PARTICIPANTS: Overall, 27 Yorkshire swine underwent 6 once-weekly unilateral retrograde instillations of MitoGel...
January 3, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28065319/xenopus-extract-approaches-to-studying-microtubule-organization-and-signaling-in-cytokinesis
#20
C M Field, J F Pelletier, T J Mitchison
We report optimized methods for preparing actin-intact Xenopus egg extract. This extract is minimally perturbed, undiluted egg cytoplasm where the cell cycle can be experimentally controlled. It contains abundant organelles and glycogen and supports active metabolism and cytoskeletal dynamics that closely mimic egg physiology. The concentration of the most abundant ∼11,000 proteins is known from mass spectrometry. Actin-intact egg extract can be used for analysis of actin dynamics and interaction of actin with other cytoplasmic systems, as well as microtubule organization...
2017: Methods in Cell Biology
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