keyword
https://read.qxmd.com/read/38657235/antipathogenic-activities-of-volatile-organic-compounds-produced-by-bacillus-velezensis-lt1-against-sclerotium-rolfsii-lc1-the-pathogen-of-southern-blight-in-coptis-chinensis
#1
JOURNAL ARTICLE
Tao Tang, Fanfan Wang, Houyun Huang, Nengneng Xie, Jie Guo, Xiaoliang Guo, Yuanyuan Duan, Xiaoyue Wang, Qingfan Wang, Jingmao You
This study explores the antipathogenic properties of volatile organic compounds (VOCs) produced by Bacillus velezensis LT1, isolated from the rhizosphere soil of Coptis chinensis . The impact of these VOCs on the mycelial growth of Sclerotium rolfsii LC1, the causative agent of southern blight in C. chinensis , was evaluated using a double Petri-dish assay. The biocontrol efficacy of these VOCs was further assessed through leaf inoculation and pot experiments. Antifungal VOCs were collected using headspace solid-phase microextraction (SPME), and their components were identified via gas chromatography-mass spectrometry (GC-MS)...
April 24, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38657216/effect-of-antimicrobial-agent-coating-on-physicochemical-and-biologic-properties-of-implant-abutments-a-systematic-review
#2
JOURNAL ARTICLE
Murilo Rodrigues de Campos, Andréa Cândido Dos Reis
PURPOSE: To analyze the effectiveness of coating of abutments with antimicrobial agents and their influence on the physicochemical and biologic properties of the coated materials. MATERIALS AND METHODS: This work was registered in Open Science Framework (osf.io/6tkcp) and followed the PRISMA protocols. A search of two independent reviewers of articles published up to October 29, 2021, was performed in the Embase, PubMed, Science Direct, and Scopus databases. RESULTS: The databases found a total of 1,474 references...
April 24, 2024: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/38657121/expanding-the-genetic-spectrum-of-agxt-gene-variants-in-egyptian-patients-with-primary-hyperoxaluria-type-i
#3
JOURNAL ARTICLE
Somayya Naguib, Lamiaa A Mansour, Neveen A Soliman, Hadeel M El-Hanafy, Yosra A Fahmy, Mohamed A Elmonem, Radwa M Abdel Halim
Introduction: Approximately 80% of primary hyperoxaluria cases are caused by primary hyperoxaluria type 1 (PH1, OMIM# 259900), which is characterized by pathogenic variants in the AGXT gene, resulting in deficiency of the liver-specific enzyme alanine-glyoxylate aminotransferase (AGT). This leads to increased production of oxalate, which cannot be effectively eliminated from the body, resulting in its accumulation primarily in the kidneys and other organs. Subjects and Methods: This study included 17 PH1 Egyptian patients from 12 unrelated families, recruited from the Inherited Kidney Disease Outpatient Clinic and the Dialysis Units, Cairo University Hospitals, during the period from January 2018 to December 2019, aiming to identify the pathogenic variants in the AGXT gene...
April 2024: Genetic Testing and Molecular Biomarkers
https://read.qxmd.com/read/38657079/natural-infection-of-murraya-paniculata-and-murraya-sumatrana-with-c-las-in-java
#4
JOURNAL ARTICLE
Ayu Lestiyani, Tri Joko, Paul Holford, George Andrew Charles Beattie, Nerida Donovan, Jianhua Mo, Siti Subandiyah, Toru Iwanami
The phloem-limited bacterium, ' Candidatus Liberibacter asiaticus' ( C Las), is the putative causal pathogen of the severe Asiatic form of huanglongbing (citrus greening) and is most commonly transmitted by the Asiatic citrus psyllid (ACP), Diaphorina citri . C Las severely affects many Citrus species and hybrids and has been recorded in the Citrus relative, orange jasmine, Murraya paniculata (L.) Jack (syn. M. exotica L.). In this study, 13 accessions of three Murraya species ( M. paniculata , M. sumatrana Roxb...
April 24, 2024: Plant Disease
https://read.qxmd.com/read/38657044/parp1-ufmylation-ensures-the-stability-of-stalled-replication-forks
#5
JOURNAL ARTICLE
Yamin Gong, Zhifeng Wang, Wen Zong, Ruifeng Shi, Wenli Sun, Sijia Wang, Bin Peng, Shunichi Takeda, Zhao-Qi Wang, Xingzhi Xu
The S-phase checkpoint involving CHK1 is essential for fork stability in response to fork stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation. However, it is unclear how the activity of PARP1 is regulated. Here, we found that UFMylation is required for the efficient activation of CHK1 by UFMylating PARP1 at K548 during replication stress. Inactivation of UFL1, the E3 enzyme essential for UFMylation, delayed CHK1 activation and inhibits nascent DNA degradation during replication blockage as seen in PARP1-deficient cells...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38657027/antigenic-distance-between-primary-and-secondary-dengue-infections-correlates-with-disease-risk
#6
JOURNAL ARTICLE
Lin Wang, Angkana T Huang, Leah C Katzelnick, Noémie Lefrancq, Ana Coello Escoto, Loréna Duret, Nayeem Chowdhury, Richard Jarman, Matthew A Conte, Irina Maljkovic Berry, Stefan Fernandez, Chonticha Klungthong, Butsaya Thaisomboonsuk, Piyarat Suntarattiwong, Warunee Vandepitte, Stephen S Whitehead, Simon Cauchemez, Derek A T Cummings, Henrik Salje
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease through a mechanism known as antibody-dependent enhancement. However, it remains unclear whether the antigenic distances between an individual's first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalizations across years...
April 24, 2024: Science Translational Medicine
https://read.qxmd.com/read/38656971/gut-microbiota-composition-in-patients-with-crohn-s-disease-in-saudi-arabia
#7
JOURNAL ARTICLE
Hadil Alahdal, Ghaida Almuneef, Manal Muhammed Alkhulaifi, Omar Aldibasi, Abdulrahman Aljouie, Othman Alharbi, Zakiah Naser Almohawes, Fatemah Basingab, Mokhtar Rejili
Crohn's disease (CD) entails intricate interactions with gut microbiome diversity, richness, and composition. The relationship between CD and gut microbiome is not clearly understood and has not been previously characterized in Saudi Arabia. We performed statistical analysis about various factors influencing CD activity and microbiota dysbiosis, including diagnosis, treatment, and its impact on their quality of life as well as high-throughput metagenomic V3-V4 16S rRNA encoding gene hypervariable region of a total of eighty patients with CD, both in its active and inactive state with healthy controls...
2024: PloS One
https://read.qxmd.com/read/38656959/long-term-hematopoietic-stem-cells-trigger-quiescence-in-leishmania-parasites
#8
JOURNAL ARTICLE
Laura Dirkx, Sara Van Acker, Yasmine Nicolaes, João Luís Reis Cunha, Rokaya Ahmad, Rik Hendrickx, Ben Caljon, Hideo Imamura, Didier G Ebo, Daniel C Jeffares, Yann G-J Sterckx, Louis Maes, Sarah Hendrickx, Guy Caljon
Addressing the challenges of quiescence and post-treatment relapse is of utmost importance in the microbiology field. This study shows that Leishmania infantum and L. donovani parasites rapidly enter into quiescence after an estimated 2-3 divisions in both human and mouse bone marrow stem cells. Interestingly, this behavior is not observed in macrophages, which are the primary host cells of the Leishmania parasite. Transcriptional comparison of the quiescent and non-quiescent metabolic states confirmed the overall decrease of gene expression as a hallmark of quiescence...
April 24, 2024: PLoS Pathogens
https://read.qxmd.com/read/38656939/neonatal-sepsis-due-to-multidrug-resistant-bacteria-at-a-tertiary-teaching-hospital-in-ethiopia
#9
JOURNAL ARTICLE
Mulatu Gashaw, Solomon Ali, Melkamu Berhane, Getnet Tesfaw, Beza Eshetu, Netsanet Workneh, Thomas Seeholzer, Guenter Froeschl, Arne Kroidl, Andreas Wieser, Esayas Kebede Gudina
BACKGROUND: The burden of multidrug-resistant bacterial infections in low-income countries is alarming. This study aimed to identify the bacterial etiologies and antibiotic resistance patterns among neonates in Jimma, Ethiopia. METHODS: An observational longitudinal study was conducted among 238 presumptive neonatal sepsis cases tested with blood and/or cerebrospinal fluid culture. The bacterial etiologies were confirmed using matrix-assisted laser desorption ionization-time of flight mass spectrometry...
April 24, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38656928/pathogenic-potential-of-a-pck1-gene-variant-in-cytosolic-pepck-deficiency-a-compelling-case-study
#10
JOURNAL ARTICLE
Monika Duś-Żuchowska, Hanna Nowak, Łukasz Kałużny, Dariusz Rokicki, Elżbieta Ciara, Dorota Piekutowska-Abramczuk, Jarosław Walkowiak
BACKGROUND Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) deficiency is an extremely rare autosomal recessive inherited error of metabolism in which gluconeogenesis is impaired, resulting in life-threatening episodes of hypoglycemia and metabolic acidosis. The diagnosis of gluconeogenesis disorders is challenging. In the diagnostic pathway, the molecular test plays a paramount role. CASE REPORT The aim of the paper is to present the case report of a girl with recurrent episodes of severe hypoglycemia, in whom molecular diagnosis enabled the confirmation of PEPCK - C deficiency...
April 24, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38656912/changing-epidemiology-and-antimicrobial-resistance-of-bacterial-childhood-diarrhea-insights-from-a-7-year-study-in-an-iranian-referral-hospital
#11
JOURNAL ARTICLE
Forough Mohamadi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Maryam Sotoudeh, Shima Mahmoudi, Setareh Mamishi
Acute gastroenteritis (AGE) poses a significant public health challenge for children in developing countries. Considering the high prevalence of AGE in Iranian children, the aim of this study was to investigate and analyze the patterns and changes in bacterial identification as well as antibiotic resistance in AG over the course of 7 years. From January 2015 to December 2021, a total of 15,300 pediatric patients with AGE were admitted to the Children's Medical Center, an Iranian academic referral hospital, Tehran, Iran...
April 24, 2024: Foodborne Pathogens and Disease
https://read.qxmd.com/read/38656793/centrifugo-pneumatic-reciprocating-flowing-coupled-with-a-spatial-confinement-strategy-for-an-ultrafast-multiplexed-immunoassay
#12
JOURNAL ARTICLE
Chungen Qian, Pengjie Li, Jingjing Wang, Xianzhe Hong, Xudong Zhao, Liqiang Wu, Zeyu Miao, Wei Du, Xiaojun Feng, Yiwei Li, Peng Chen, Bi-Feng Liu
Immunoassays serve as powerful diagnostic tools for early disease screening, process monitoring, and precision treatment. However, the current methods are limited by high costs, prolonged processing times (>2 h), and operational complexities that hinder their widespread application in point-of-care testing. Here, we propose a novel centrifugo- p neumatic r eciprocating flowing coupled with spatial c onfinement strategy, termed PRCM , for ultrafast multiplexed immunoassay of pathogens on a centrifugal m icrofluidic platform...
April 24, 2024: Analytical Chemistry
https://read.qxmd.com/read/38656785/transmissible-cancers-the-genomes-that-don-t-melt-down
#13
JOURNAL ARTICLE
Georgina Bramwell, James DeGregori, Frédéric Thomas, Beata Ujvari
Evolutionary theory predicts that accumulation of deleterious mutations in asexually reproducing organisms should lead to genomic decay. Clonally reproducing cell lines, i.e., transmissible cancers, when cells are transmitted as allografts/xenografts, break these rules, and survive for centuries and millennia. The currently known 11 transmissible cancer lineages occur in dogs (Canine Venereal Tumour Disease, CTVT), in Tasmanian devils (Devil Facial Tumour Diseases, DFT 1 and DFT2) and in bivalves (bivalve transmissible neoplasia, BTN)...
April 24, 2024: Evolution; International Journal of Organic Evolution
https://read.qxmd.com/read/38656724/constructed-rice-tracers-identify-the-major-virulent-transcription-activator-like-effectors-of-the-bacterial-leaf-blight-pathogen
#14
JOURNAL ARTICLE
Linlin Liu, Ying Li, Qi Wang, Xiameng Xu, Jiali Yan, Yong Wang, Yijie Wang, Syed Mashab Ali Shah, Yongzheng Peng, Zhangfei Zhu, Zhengyin Xu, Gongyou Chen
Xanthomonas oryzae pv. oryzae (Xoo) injects major transcription activator-like effectors (TALEs) into plant cells to activate susceptibility (S) genes for promoting bacterial leaf blight in rice. Numerous resistance (R) genes have been used to construct differential cultivars of rice to identify races of Xoo, but the S genes were rarely considered. Different edited lines of rice cv. Kitaake were constructed using CRISPR/Cas9 gene-editing, including single, double and triple edits in the effector-binding elements (EBEs) located in the promoters of rice S genes OsSWEET11a, OsSWEET13 and OsSWEET14...
April 24, 2024: Rice
https://read.qxmd.com/read/38656697/integrated-approaches-for-solenopsis-invicta-hymenoptera-formicidae-management-insights-from-laboratory-studies-with-entomopathogenic-nematodes-and-insecticides
#15
JOURNAL ARTICLE
Sheng-Yen Wu, Huatao Tang, Shengmei Ban, Ruiqi Wen, Xifan Mao, Honghong Deng, Mohamed Kamal Abbas, Salem Mohamed Salem, Youming Hou
BACKGROUND: In agricultural pest management, especially in combatting the invasive red imported fire ant (RIFA, Solenopsis invicta), significant challenges emerge due to the constraints of solely depending on chemical insecticides or entomopathogenic nematodes (EPNs). The utilization of chemical insecticides carries environmental and ecological hazards, whereas EPNs, when applied independently, might not offer the immediate effectiveness necessary for adequate RIFA suppression. Acknowledging these hurdles, our study investigates a synergistic method that integrates EPNs with chemical insecticides, aiming to fulfill the urgent demand for more efficient and environmentally friendly pest control solutions...
April 24, 2024: Pest Management Science
https://read.qxmd.com/read/38656637/mir-210-5p-promotes-pulmonary-hypertension-by-blocking-atp2a2
#16
JOURNAL ARTICLE
Boxiang Wang, Yidin Xu, Yilun Huang, Siming Shao, Dongshan Xu, Yiying Zhang, Lingxia Pang, Zhuofan Nan, Qianxi Ye, Yang Wang, Wantie Wang, Keke Jin, Linbo Yuan
AIM: Aberrant expression of ATPase sarcoplasmic/endoplasmic retic Ca2+  transporting 2 (ATP2A2) has attracted attention for its pathophysiologic role in pulmonary hypertension (PH). Several miRNAs, including miR-210-5p, have also been reported to be pathogenic factors in PH, but their exact mechanisms remain unknown. This study aimed to elucidate the potential mechanisms of miR-210-5p and ATP2A2 in MCT-induced PH. METHODS: Eighteen Sprague-Dawley rats were randomly divided into two groups-monoclonal (MCT) group and control group-and then administered MCT (60 mg/kg) and saline, respectively...
April 24, 2024: Cardiovascular Drugs and Therapy
https://read.qxmd.com/read/38656598/design-and-synthesis-of-new-quinazolinone-derivatives-investigation-of-antimicrobial-and-biofilm-inhibition-effects
#17
JOURNAL ARTICLE
Rasha Mohamed Hassan, Heba Yehia, Mohammed F El-Behairy, Aida Abdel-Sattar El-Azzouny, Mohamed Nabil Aboul-Enein
New quinazolin-4-ones 9-32 were synthesized in an attempt to overcome the life-threatening antibiotic resistance phenomenon. The antimicrobial screening revealed that compounds 9, 15, 16, 18, 19, 20 and 29 are the most broad spectrum antimicrobial agents in this study with safe profile on human cell lines. Additionally, compounds 19 and 20 inhibited biofilm formation in Pseudomonas aeruginosa, which is regulated by quorum sensing system, at sub-minimum inhibitory concentrations (sub-MICs) with IC50 values 3...
April 24, 2024: Molecular Diversity
https://read.qxmd.com/read/38656594/perinatal-outcome-in-anti-nmdar-encephalitis-during-pregnancy-a-systematic-review-with-individual-patients-data-analysis
#18
REVIEW
Giovanna Scorrano, Fedele Dono, Clarissa Corniello, Stefano Consoli, Giacomo Evangelista, Armando Di Ludovico, Francesco Chiarelli, Francesca Anzellotti, Angelo Di Iorio, Stefano L Sensi
INTRODUCTION: Anti-N-methyl-D-aspartate receptor (NMDAr) antibody encephalitis is an autoimmune disorder characterized by synaptic NMDAr current disruption and receptor hypofunction, often affecting women during pregnancy. Clinical manifestations associated with anti-NMDAr encephalitis can occur both in the mother and fetus. METHODS: We generated a systematic search of the literature to identify epidemiological, clinical, and serological data related to pregnant women with anti-NMDAr encephalitis and their children, analyzing the fetal outcomes...
April 24, 2024: Neurological Sciences
https://read.qxmd.com/read/38656548/antifungal-and-antivirulence-activity-of-vanillin-and-tannic-acid-against-aspergillus-fumigatus-and-fusarium-solani
#19
JOURNAL ARTICLE
Ana L Ríos-López, Jorge Dávila-Aviña, Gloria M González, Orlando Flores-Maldonado
Aspergillus fumigatus and Fusarium solani infections have become severe health threat; both pathogens are considered a priority due to the increasing emergence of antifungal-resistant strains and high mortality rates. Therefore, the discovery of new therapeutic strategies has become crucial. In this study, we evaluated the antifungal and antivirulence effects of vanillin and tannic acid against Aspergillus fumigatus and Fusarium solani. The minimum inhibitory concentrations of the compounds were determined by the microdilution method in RPMI broth in 96-well microplates according to CLSI...
April 24, 2024: Current Microbiology
https://read.qxmd.com/read/38656507/identification-of-volatiles-in-tomato-fruit-using-headspace-solid-phase-micro-extraction-hs-spme-coupled-with-gas-chromatography-mass-spectrometry-gc-ms
#20
JOURNAL ARTICLE
Prateek Gupta, Ajayakumar Jaya Dhanya, Rameshwar Sharma, Yellamaraju Sreelakshmi
Plant volatile organic compounds (VOCs) are organic chemicals that plants release as part of their natural biological processes. Various plant tissues produce VOCs, including leaves, stems, flowers, and roots. VOCs are essential in plant communication, defense against pests and pathogens, aroma and flavor, and attracting pollinators. The study of plant volatiles has become an increasingly important area of research in recent years, as scientists have recognized these compounds' important roles in plant physiology...
2024: Methods in Molecular Biology
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