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https://www.readbyqxmd.com/read/28206771/magnetic-particle-imaging-a-novel-in-vivo-imaging-platform-for-cancer-detection
#1
Elaine Y Yu, Mindy Bishop, Bo Zheng, R Matthew Ferguson, Amit P Khandhar, Scott J Kemp, Kannan M Krishnan, Patrick W Goodwill, Steven M Conolly
Cancer remains one of the leading causes of death worldwide. Biomedical imaging plays a crucial role in all phases of cancer management. Physicians often need to choose the ideal diagnostic imaging modality for each clinical presentation based on complex trade-offs between spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle imaging (MPI) is an emerging tracer imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracer with high image contrast (zero tissue background signal), high sensitivity (200 nM Fe) with linear quantitation and zero signal depth attenuation...
February 16, 2017: Nano Letters
https://www.readbyqxmd.com/read/28196643/radiotherapy-after-sentinel-lymph-node-biopsy-slnb-using-sienna-%C3%A2-super-paramagnetic-iron-oxide-particles-spio-prospective-study-of-tolerance-and-toxicity
#2
Youlia M Kirova, Anne Chilles, Nathalie Ly, Anne Tardivon, Severine Alran
No abstract text is available yet for this article.
February 10, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28177301/tracking-short-term-biodistribution-and-long-term-clearance-of-spio-tracers-in-magnetic-particle-imaging
#3
Paul Keselman, Elaine Yu, Xinyi Zhou, Patrick Goodwill, Prashant Chandrasekharan, R Matthew Ferguson, Amit Khandhar, Scott Kemp, Kannan Krishnan, Bo Zheng, Steven Conolly
Magnetic Particle Imaging (MPI) is an emerging tracer-based medical imaging modality that images non-radioactive, kidney-safe superparamagnetic iron oxide (SPIO) tracers. MPI offers quantitative, high-contrast and high-SNR images, so MPI has exceptional promise for applications such as cell tracking, angiography, brain perfusion, cancer detection, traumatic brain injury and pulmonary imaging. In assessing MPI's utility for applications mentioned above, it is important to be able to assess tracer short-term biodistribution as well as long-term clearance from the body...
February 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28160221/simultaneous-detection-of-hepatocellular-carcinoma-and-vessel-thrombus-by-using-spio-enhanced-b-tfe-with-the-t2-preparation-pulse-technique
#4
Masayuki Kanamoto, Tosiaki Miyati, Kazuki Terashima, Kei Katahira, Ryoji Ida, Daisaku Suga, Nobukazu Fuwa
The purpose of this study was to compare between superparamagnetic iron oxide (SPIO)-enhanced three-dimensional balanced turbo field-echo (B-TFE) sequence with T2 preparation pulse (T2 prep) and T2*-weighted imaging (T2*WI) for the simultaneous detection of hepatocellular carcinoma (HCC) and vessel thrombus. For 1.5-T magnetic resonance imaging, SPIO was administered to 23 patients with a portal or venous tumor thrombus, and B-TFE with T2 prep and T2*WI were acquired. Regions of interest in the B-TFE and T2*WI were selected for the tumor, liver, tumor thrombus, and vessels...
February 3, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/28150848/polymer-hybrid-magnetic-nanocapsules-encapsulating-ir820-and-ptx-for-external-magnetic-field-guided-tumor-targeting-and-multifunctional-theranostics
#5
JinFeng Liao, XiaWei Wei, Bei Ran, JinRong Peng, Ying Qu, ZhiYong Qian
Developing multifunctional nanoparticle-based theranostic systems for personalized cancer diagnosis and treatment is highly desirable. Herein, a magnetic targeting theranostic nanocapsule (NC-SPIOs-IR820-PTX) was fabricated by hierarchically assembling superparamagnetic iron oxide nanoparticles (SPIOs), cyanine dye (IR820) and chemotherapeutic compound of paclitaxel (PTX) with poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide) (PCLA-PEG-PCLA). The nanocapsules exhibited high stability and biocompatibility both in vitro and in vivo...
February 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28132997/polymer-brush-afforded-spio-nanoparticles-show-a-unique-biodistribution-and-mr-imaging-contrast-in-mouse-organs
#6
Ting Chen, Yuki Mori, Chizuko Inui-Yamamoto, Yutaka Komai, Yoshiyuki Tago, Shinichi Yoshida, Yoshitsugu Takabatake, Yoshitaka Isaka, Kohji Ohno, Yoshichika Yoshioka
INTRODUCTION: To investigate the biodistribution and retention properties of the new super paramagnetic iron oxide (new SPIO: mean hydrodynamic diameter, 100 nm) nanoparticles, which have concentrated polymer brushes in the outer shell and are difficult for phagocytes to absorb, and to compare the new SPIO with clinically approved SPIO (Resovist: mean hydrodynamic diameter, 57 nm). MATERIALS AND METHODS: 16 male C57BL/6N mice were divided in two groups according to the administered SPIO (n = 8 for each group; intravenous injection does, 0...
January 30, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28113546/magnetic-particle-imaging-a-resovist-based-marking-technology-for-guide-wires-and-catheters-for-vascular-interventions
#7
Julian Haegele, Sjef Cremers, Jurgen Rahmer, Jochen Franke, Sarah Vaalma, Michael Heidenreich, Joern Borgert, Paul Borm, Joerg Barkhausen, Florian Vogt
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, high signal to noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over a wide range practically relevant concentrations. Thus, MPI is proposed as a promising future method for guidance of vascular interventions. To implement this, devices such as guide wires and catheters have to be discernible in MPI, which can be achieved by coating already commercially available devices with SPIOs...
April 27, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28111435/an-evaluation-of-heat-on-protein-oxidation-of-soy-protein-isolate-or-soy-protein-isolate-mixed-with-soybean-oil-in-vitro-and-its-consequences-on-redox-status-of-broilers-at-early-age
#8
Xianglun Zhang, Peng Lu, Wenyue Xue, Dawei Wu, Chao Wen, Yanmin Zhou
Objective: The objective of this study was to evaluate effects of heat treatment and soybean oil inclusion on protein oxidation of soy protein isolate (SPI) and of oxidized protein on redox status of broilers at an early age. Methods: SPI mixed with soybean oil (SPIO) heated at 100°C for 8 h was used to evaluate protein oxidation of SPI. A total of two hundred and sixteen 1-day-old Arbor Acres chicks were divided into 3 groups with 6 replicates of 12 birds, receiving basal diet (CON), heat-oxidized SPI diet (HSPI) or mixture of SPI and 2% soybean oil diet (HSPIO) for 21 d, respectively...
January 13, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28106540/detection-of-human-breast-cancer-cells-using-a-2-deoxy-d-glucose-functionalized-superparamagnetic-iron-oxide-nanoparticles
#9
Xiu-Hong Shan, Peng Wang, Fei Xiong, Hao-Yue Lu, Hui Hu
BACKGROUND: Breast cancer is one of the most common type of female cancer worldwide and represents 14% of cancer-related deaths in women. Early detection is the most important factor for treatment and prognosis of breast cancer. In most countries, the women are currently screened with mammography only. Even though there has been considerable progress in the detection, surgical therapy, hormonal and target therapy of breast cancer, there are about ∼ 3500 000 women who die from breast cancer each year...
January 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28102523/the-effect-of-superparamagnetic-iron-oxide-nanoparticle-surface-charge-on-antigen-cross-presentation
#10
Yongbin Mou, Yun Xing, Hongyan Ren, Zhihua Cui, Yu Zhang, Guangjie Yu, Walter J Urba, Qingang Hu, Hongming Hu
Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical modifications and surface charges were used to study the mechanism of action of antigen delivery. Specifically, two types of magnetic NPs, γFe2O3/APTS (3-aminopropyltrimethoxysilane) NPs and γFe2O3/DMSA (meso-2, 3-Dimercaptosuccinic acid) NPs, with the same crystal structure, magnetic properties, and size distribution were prepared...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28059427/evaluation-of-peg-coated-iron-oxide-nanoparticles-as-blood-pool-tracers-for-preclinical-magnetic-particle-imaging
#11
A P Khandhar, P Keselman, S J Kemp, R M Ferguson, P W Goodwill, S M Conolly, K M Krishnan
Superparamagnetic iron oxide (SPIO) nanoparticles with optimized and well-characterized properties are critical for Magnetic Particle Imaging (MPI). MPI is a novel in vivo imaging modality that promises to integrate the speed of X-ray CT, safety of MRI and sensitivity of PET. Since SPIOs are the source of MPI signal, both the core and surface properties must be optimized to enable efficient in vivo imaging with pharmacokinetics tailored for specific imaging applications. Existing SPIOs like Resovist (ferucarbotran) provide a suboptimal MPI signal, and further limit MPI's in vivo utility due to rapid systemic clearance...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28056877/antenatal-care-trial-interventions-a-systematic-scoping-review-and-taxonomy-development-of-care-models
#12
Andrew Symon, Jan Pringle, Soo Downe, Vanora Hundley, Elaine Lee, Fiona Lynn, Alison McFadden, Jenny McNeill, Mary J Renfrew, Mary Ross-Davie, Edwin van Teijlingen, Heather Whitford, Fiona Alderdice
BACKGROUND: Antenatal care models vary widely around the world, reflecting local contexts, drivers and resources. Randomised controlled trials (RCTs) have tested the impact of multi-component antenatal care interventions on service delivery and outcomes in many countries since the 1980s. Some have applied entirely new schemes, while others have modified existing care delivery approaches. Systematic reviews (SRs) indicate that some specific antenatal interventions are more effective than others; however the causal mechanisms leading to better outcomes are poorly understood, limiting implementation and future research...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28056102/magnetic-particle-imaging-mpi-experimental-quantification-of-vascular-stenosis-using-stationary-stenosis-phantoms
#13
Sarah Vaalma, Jürgen Rahmer, Nikolaos Panagiotopoulos, Robert L Duschka, Jörn Borgert, Jörg Barkhausen, Florian M Vogt, Julian Haegele
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, high signal-to-noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs). Because of that, MPI is proposed to be a promising future method for cardiovascular imaging. Here, an interesting application may be the quantification of vascular pathologies like stenosis by utilizing the proportionality of the SPIO concentration and the MPI signal strength...
2017: PloS One
https://www.readbyqxmd.com/read/28044245/mri-detection-of-endothelial-cell-inflammation-using-targeted-superparamagnetic-particles-of-iron-oxide-spio
#14
Joyce M S Chan, Maggie S H Cheung, Richard G J Gibbs, Kishore K Bhakoo
BACKGROUND: There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron oxide (SPIO) as a magnetic resonance imaging (MRI) probe for detecting inflamed endothelial cells. METHODS: The in vitro study consists of the characterisation and detection of inflammatory markers on activated endothelial cells by immunocytochemistry and MRI using biotinylated anti-P-selectin and anti-VCAM-1 (vascular cell adhesion molecule 1) antibody and streptavidin conjugated SPIO...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28040662/development-and-application-of-micro-polysaccharide-drug-carriers-incorporating-doxorubicin-and-superparamagnetic-iron-oxide-for-bimodality-treatment-of-hepatocellular-carcinoma
#15
Sung-Ling Tang, Meng-Yi Bai, Jyun-Yi Wang, Po-Da Hong
In this study, we demonstrated a novel polyelectrolyte microparticle, doxorubicin(DOX)-superparamagnetic iron oxide (SPIO)-chondroitin sulfate (CS)/chitosan (CHI)microparticles (MPs), as a drug delivery system for hepatic cancer treatment. We also investigated the properties of these microparticles through composition determination, formulation tests, in vitro study, and in vivo study. The results showed that our DOX-SPIO-CS/CHI MPs had an average diameter of 1.43±0.54μm and exhibited a spherical shape. The encapsulation efficiency of this drug carrier was approximately 31±8...
December 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28024568/study-and-evaluation-of-nucleolin-targeted-delivery-of-magnetic-plga-peg-nanospheres-loaded-with-doxorubicin-to-c6-glioma-cells-compared-with-low-nucleolin-expressing-l929-cells
#16
Jafar Mosafer, Manouchehr Teymouri, Khalil Abnous, Mohsen Tafaghodi, Mohammad Ramezani
Magnetic nanoparticulate systems based on polymeric materials such as poly (lactic-co-glycolic acid) (PLGA(1)) are being studied for their potential applications in targeted therapy and imaging of malignant tumors. In the current study, superparamagnetic iron oxide nanocrystals (SPIONs(2)) and doxorubicin (Dox(3)) were entrapped in the PLGA-based nanoparticles via a modified multiple emulsion solvent evaporation method. Furthermore, SPIO/Dox-NPs(4) were conjugated to anti-nucleolin AS1411 aptamer (Apt(5)) and their targeting ability was investigated in high nucleolin-expressing C6 glioma cells compared to low nucleolin-expressing L929 cells...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28012991/in-vitro-and-in-vivo-evaluation-of-anti-nucleolin-targeted-magnetic-plga-nanoparticles-loaded-with-doxorubicin-as-a-theranostic-agent-for-enhanced-targeted-cancer-imaging-and-therapy
#17
Jafar Mosafer, Khalil Abnous, Mohsen Tafaghodi, Ahad Mokhtarzadeh, Mohammad Ramezani
A superparamagnetic iron oxide nanoparticles (SPIONs(1))/doxorubicin (Dox(2)) co-loaded poly(lactic-co-glycolic acid) (PLGA(3))-based nanoparticles targeted with AS1411 aptamer (Apt(4)) against murine C26 colon carcinoma cells is successfully developed via a modified multiple emulsion solvent evaporation method for theranostic purposes. The mean size of SPIO/Dox-NPs(5) (NPs) was 130 nm with a narrow particle size distribution and Dox loading of 3.0%. The SPIO loading of 16.0% and acceptable magnetic properties are obtained and analyzed using thermogravimetric and vibration simple magnetometer analysis, respectively...
December 21, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27991598/using-anti-poly-ethylene-glycol-bioparticles-for-the-quantitation-of-pegylated-nanoparticles
#18
Yuan-Chin Hsieh, Ta-Chun Cheng, Hsin-Ell Wang, Jia-Je Li, Wen-Wei Lin, Chien-Chiao Huang, Chih-Hung Chuang, Yeng-Tseng Wang, Jaw-Yuan Wang, Steve R Roffler, Kuo-Hsiang Chuang, Tian-Lu Cheng
Attachment of polyethylene glycol (PEG) molecules to nanoparticles (PEGylation) is a widely-used method to improve the stability, biocompatibility and half-life of nanomedicines. However, the evaluation of the PEGylated nanomedicine pharmacokinetics (PK) requires the decomposition of particles and purification of lead compounds before analysis by high performance liquid chromatography (HPLC), mass spectrometry, etc. Therefore, a method to directly quantify un-decomposed PEGylated nanoparticles is needed. In this study, we developed anti-PEG bioparticles and combined them with anti-PEG antibodies to generate a quantitative enzyme-linked immunosorbent assay (ELISA) for direct measurement of PEGylated nanoparticles without compound purification...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977143/magnetite-nanoparticles-for-stem-cell-labeling-with-high-efficiency-and-long-term-in-vivo-tracking
#19
Noelia Guldris, Bárbara Argibay, Juan Gallo, Ramón Iglesias-Rey, Enrique Carbó-Argibay, Yury V Kolen'ko, Francisco Campos, Tomás Sobrino, Laura M Salonen, Manuel Bañobre-López, José Castillo, José Rivas
Superparamagnetic iron oxide nanoparticles (SPIO-PAA), ultrasmall iron oxide nanoparticles (USPIO-PAA), and glucosamine-modified iron oxide nanoparticles (USPIO-PAA-GlcN) were studied as mesenchymal stem cell (MSCs) labels for cell tracking applications by magnetic resonance imaging (MRI). Pronounced differences were found in the labeling performance of the three samples in terms of cellular dose and labeling efficiency. In combination with polylysine, SPIO-PAA showed nonhomogeneous cell internalization, while for USPIO-PAA no uptake was found...
December 15, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#20
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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