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https://www.readbyqxmd.com/read/28877348/superparamagnetic-iron-oxide-nanoparticles-as-the-sole-method-for-sentinel-node-biopsy-detection-in-patients-with-breast-cancer
#1
A Karakatsanis, K Daskalakis, P Stålberg, H Olofsson, Y Andersson, S Eriksson, L Bergkvist, F Wärnberg
BACKGROUND: Sentinel node biopsy (SNB) using superparamagnetic iron oxide (SPIO) nanoparticles is a novel method in breast cancer. Several studies have verified the non-inferiority of SPIO compared with the standard use of radioisotope (99m) Tc with or without blue dye. The aim of the MONOS study presented here was to evaluate the use of SPIO as a sole tracer and the efficacy of tracer injection in the preoperative setting. METHODS: This prospective cohort study was carried out in two hospitals, one using (99m) Tc and the other SPIO...
September 6, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28869707/spio-au-core-shell-nanoparticles-for-promoting-osteogenic-differentiation-of-mc3t3-e1-cells-concentration-dependence-study
#2
Muzhaozi Yuan, Ya Wang, Yi-Xian Qin
This work aims to explore the concentration-dependence of SPIO-Au core-shell NPs (17.3 ± 1.2 nm in diameter) on biocompatibility and osteogenic differentiation of preosteoblast MC3T3-E1 cells. The stability of NPs was first investigated by UV-Vis absorption spectra and zeta potential measurement. Then concentration effects of NPs (1-80 μg/mL) were evaluated on viability, morphology, proliferation, cellular uptake and alkaline phosphate (ALP) activity levels. Results have shown strong stability and no acute toxicity (viability > 93%) or morphological difference at all concentration levels of NPs...
September 4, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28842333/a-theranostic-dental-pulp-capping-agent-with-improved-mri-and-ct-contrast-and-biological-properties
#3
S Mastrogiacomo, N Güvener, W Dou, H S Alghamdi, W A Camargo, J G O Cremers, P J A Borm, A Heerschap, E Oosterwijk, J A Jansen, X F Walboomers
Different materials have been used for vital dental pulp treatment. Preferably a pulp capping agent should show appropriate biological performance, excellent handling properties, and a good imaging contrast. These features can be delivered into a single material through the combination of therapeutic and diagnostic agents (i.e. theranostic). Calcium phosphate based composites (CPCs) are potentially ideal candidate for pulp treatment, although poor imaging contrast and poor dentino-inductive properties are limiting their clinical use...
August 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28825892/development-of-an-electroporation-and-nanoparticle-based-therapeutic-platform-for-bone-metastases
#4
Marites P Melancon, Tomas Appleton Figueira, David T Fuentes, Li Tian, Yang Qiao, Jianhua Gu, Mihai Gagea, Joe E Ensor, Nina M Muñoz, Kiersten L Maldonado, Katherine Dixon, Amanda McWatters, Jennifer Mitchell, Mark McArthur, Sanjay Gupta, Alda L Tam
Purpose To assess for nanopore formation in bone marrow cells after irreversible electroporation (IRE) and to evaluate the antitumoral effect of IRE, used alone or in combination with doxorubicin (DOX)-loaded superparamagnetic iron oxide (SPIO) nanoparticles (SPIO-DOX), in a VX2 rabbit tibial tumor model. Materials and Methods All experiments were approved by the institutional animal care and use committee. Five porcine vertebral bodies in one pig underwent intervention (IRE electrode placement without ablation [n = 1], nanoparticle injection only [n = 1], and nanoparticle injection followed by IRE [n = 3])...
August 21, 2017: Radiology
https://www.readbyqxmd.com/read/28821761/enhanced-therapeutic-effects-of-human-ips-cell-derived-cardiomyocyte-by-combined-cell-sheets-with-omental-flap-technique-in-porcine-ischemic-cardiomyopathy-model
#5
Masashi Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Kenji Miki, Shunsuke Funakoshi, Yoshinori Yoshida, Shinya Yamanaka, Tatsuya Shimizu, Teruo Okano, Takashi Daimon, Koichi Toda, Yoshiki Sawa
Transplant of human induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) cell-sheet is a promising approach for treating ischemic cardiomyopathy (ICM). However, poor blood supply to the transplanted cell-sheet is a concern related to the effectiveness and durability of the treatment. Herein, we hypothesized that the combined the omentum flap might enhance survival and the therapeutic effects of hiPS-CM cell-sheet transplant for ICM treatment. Treatment by Wnt signaling molecules in hiPS cells produced hiPS-CMs, which were magnetically labeled by superparamagnetic iron oxide (SPIO), followed by culture in the thermoresponsive dishes to generate hiPS-CMs cell-sheets...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811932/two-novel-direct-spio-labels-and-in%C3%A2-vivo-mri-detection-of-labeled-cells-after-acute-myocardial-infarct
#6
Riikka M Korpi, Kirsi Alestalo, Timo Ruuska, Eveliina Lammentausta, Ronald Borra, Fredrik Yannopoulos, Siri Lehtonen, Jarkko T Korpi, Elisa Lappi-Blanco, Vesa Anttila, Petri Lehenkari, Tatu Juvonen, Roberto Blanco Sequieros
BACKGROUND: Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Cellular decay due hypoxia requires rapid and validated methods for possible therapeutic cell transplantation. PURPOSE: To develop direct and rapid superparamagnetic iron oxide (SPIO) cell label for a large-animal model and to assess in vivo cell targeting by magnetic resonance imaging (MRI) in an experimental AMI model. MATERIAL AND METHODS: Bone marrow mononuclear cells (BMMNCs) were labeled with SPIO particles using two novel direct labeling methods (rotating incubation method and electroporation)...
August 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28789586/comparative-study-of-superparamagnetic-iron-oxide-doxorubicin-co-loaded-poly-lactic-co-glycolic-acid-nanospheres-prepared-by-different-emulsion-solvent-evaporation-methods
#7
Jafar Mosafer, Manouchehr Teymouri
Poly (lactic-co-glycolic acid) (PLGA) is a widely used biodegradable polymer for preparation of polymeric biodegradable carriers that shows attractive features and offers possibilities to tune the physicochemical characteristics, drug release properties and biological behaviour of the PLGA-based nanospheres. Double emulsion solvent evaporation methods fail when it comes to encapsulation of highly hydrophilic drugs such as doxorubicin (Dox). The reason for this defect is due to the rapid drug diffusion into the external aqueous phase before solidification of the PLGA nanospheres...
August 9, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28750340/activatable-interpolymer-complex-superparamagnetic-iron-oxide-nanoparticles-as-magnetic-resonance-contrast-agents-sensitive-to-oxidative-stress
#8
Eunsoo Yoo, Huaitzung A Cheng, Lauren E Nardacci, David J Beaman, Charles T Drinnan, Carmen Lee, Kenneth W Fishbein, Richard G Spencer, Omar Z Fisher, Amber L Doiron
Magnetic resonance contrast agents that can be activated in response to specific triggers hold potential as molecular biosensors that may be of great utility in non-invasive disease diagnosis. We developed an activatable agent based on superparamagnetic iron oxide nanoparticles (SPIOs) that is sensitive to oxidative stress, a factor in the pathophysiology of numerous diseases. SPIOs were coated with poly(ethylene glycol) (PEG) and complexed with poly(gallol), a synthetic tannin. Hydrogen bonding between PEG and poly(gallol) creates a complexed layer around the SPIO that decreases the interaction of solute water with the SPIO, attenuating its magnetic resonance relaxivity...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28748623/photoacoustic-guided-surgery-with-indocyanine-green-coated-superparamagnetic-iron-oxide-nanoparticle-clusters
#9
Jayesh P Thawani, Ahmad Amirshaghaghi, Lesan Yan, Joel M Stein, Jessica Liu, Andrew Tsourkas
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real-time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable...
July 27, 2017: Small
https://www.readbyqxmd.com/read/28654377/image-based-analysis-of-tumor-localization-after-intra-arterial-delivery-of-technetium-99m-labeled-spio-using-spect-ct-and-mri
#10
In Joon Lee, Ji Yong Park, Young-Il Kim, Yun-Sang Lee, Jae Min Jeong, Jaeil Kim, Euishin Edmund Kim, Keon Wook Kang, Dong Soo Lee, Seonji Jeong, Eun Jeong Kim, Young Il Kim, Jin Wook Chung
The aim of this study is to evaluate the localization of (99m)Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered (99m)Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of (99m)Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28652736/magnetic-alginate-microspheres-detected-by-mri-fabricated-using-microfluidic-technique-and-release-behavior-of-encapsulated-dual-drugs
#11
Qin Wang, Shanshan Liu, Fan Yang, Lu Gan, Xiangliang Yang, Yajiang Yang
Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28644801/magnetic-particle-imaging-for-quantification-of-vascular-stenoses-a-phantom-study
#12
S Herz, P Vogel, T Kampf, M A Ruckert, S Veldhoen, V C Behr, T A Bley
Magnetic particle imaging (MPI) is a promising new tomographic imaging method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim of this study was to investigate the potential of MPI to quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees of stenosis (0 %, 25 %, 50 %, 75 % and 100 %) were scanned in a custom-built MPI scanner (in-plane resolution: ~ 1-1.5 mm, field of view: 65 × 29 × 29 mm3)...
June 21, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28638483/thermoacoustic-imaging-and-therapy-guidance-based-on-ultra-short-pulsed-microwave-pumped-thermoelastic-effect-induced-with-superparamagnetic-iron-oxide-nanoparticles
#13
Liewei Wen, Sihua Yang, Junping Zhong, Quan Zhou, Da Xing
Multifunctional nanoparticle-mediated imaging and therapeutic techniques are promising modalities for accurate localization and targeted treatment of cancer in clinical settings. Thermoacoustic (TA) imaging is highly sensitive to detect the distribution of water, ions or specific nanoprobes and provides excellent resolution, good contrast and superior tissue penetrability. TA therapy is a potential non-invasive approach for the treatment of deep-seated tumors. In this study, human serum albumin (HSA)-functionalized superparamagnetic iron oxide nanoparticle (HSA-SPIO) is used as a multifunctional nanoprobe with clinical application potential for MRI, TA imaging and treatment of tumor...
2017: Theranostics
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#14
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28591953/-magnetic-resonance-imaging-tracing-the-biodistribution-of-spio-shrna-molecular-probe-in-vivo
#15
Xiao-Lin Deng, Xiao-Feng Wu, Rui-Kun Liao, Dan-Ni Zeng, Ming Wen, Shao-Lin Li
OBJECTIVES: To investigate the biodistribution of superparamagnetic iron oxide (SPIO)-shRNA molecular probe by magnetic resonance imaging (MRI) in vivo. METHODS: Six New Zealand white rabbits were injected intravenously with SPIO-shRNA molecular probe (9.6 mg Fe/kg) via ear edge vein. The blood samples were collected to analyse the pharmacokinetic parameters through measuring the iron content by atomic absorption spectrometry (AAS) method at 30 min before and 1 min, 3 min, 5 min, 10 min, 15 min, 30 min and at 1, 2, 3, 6, 12, and 24 h after the injection...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28566744/mri-tracking-of-autologous-pancreatic-progenitor-derived-insulin-producing-cells-in-monkeys
#16
Chunlin Zou, Yi Lu, Xiahong Teng, Shuyan Wang, Xiaoting Sun, Fen Huang, Guannan Shu, Xin Huang, Hongwei Guo, Zhiguo Chen, Jian Zhang, Yu Alex Zhang
Insulin-producing cells (IPCs) derived from a patient's own stem cells offer great potential for autologous transplantation in diabetic patients. However, the limited survival of engrafted cells remains a bottleneck in the application of this strategy. The present study aimed to investigate whether nanoparticle-based magnetic resonance (MR) tracking can be used to detect the loss of grafted stem cell-derived IPCs in a sensitive and timely manner in a diabetic monkey model. Pancreatic progenitor cells (PPCs) were isolated from diabetic monkeys and labeled with superparamagnetic iron oxide nanoparticles (SPIONs)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539289/-effect-of-superparamagnetic-iron-oxide-on-differentiation-of-rat-bone-marrow-stem-cells-into-chondrocytes-in-vitro
#17
Fang Jiang, Ji-Jie Xiao, Yuan-Ting Lu, Wei Li, Yu-Wen Duan, Zong-Hai Sheng, Shao-Lin Li
OBJECTIVE: To observe the effect of superparamagnetic iron oxide (SPIO) on the differentiation of rat bone marrow stem cells (BMSCs) into chondrocytes in vitro and explore the possible mechanism. METHODS: CCK8 assay was performed to examine the cytotoxicity of SPIO (1 and 5 µg/mL) on cultured SD rat BMSCs. Prussian blue staining and fluorescence excitation assay were used to assess the binding of the SPIO to BMSCs after the cells had been cultured in chondrocytes-induced medium in the presence of SPIO (1 and 5 µg/mL) for 9 days...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28492491/magnetic-cationic-amylose-nanoparticles-used-to-deliver-survivin-small-interfering-rna-for-gene-therapy-of-hepatocellular-carcinoma-in-vitro
#18
Zhuo Wu, Xiao-Lin Xu, Jun-Zhao Zhang, Xu-Hong Mao, Ming-Wei Xie, Zi-Liang Cheng, Lie-Jing Lu, Xiao-Hui Duan, Li-Ming Zhang, Jun Shen
Amylose is a promising nanocarrier for gene delivery in terms of its good biocompatibility and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can cause tumor apoptosis by silencing a hepatocellular carcinoma (HCC)-specific gene at the messenger RNA level. In this study, we developed a new class of folate-functionalized, superparamagnetic iron oxide (SPIO)-loaded cationic amylose nanoparticles to deliver survivin-siRNA to HCC cells. The cellular uptake of nanocomplexes, cytotoxicity, cell apoptosis, and gene suppression mediated by siRNA-complexed nanoparticles were tested...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28467814/contribution-of-macrophages-in-the-contrast-loss-in-iron-oxide-based-mri-cancer-cell-tracking-studies
#19
Pierre Danhier, Gladys Deumer, Nicolas Joudiou, Caroline Bouzin, Philippe Levêque, Vincent Haufroid, Bénédicte F Jordan, Olivier Feron, Pierre Sonveaux, Bernard Gallez
Magnetic resonance imaging (MRI) cell tracking of cancer cells labeled with superparamagnetic iron oxides (SPIO) allows visualizing metastatic cells in preclinical models. However, previous works showed that the signal void induced by SPIO on T2(*)-weighted images decreased over time. Here, we aim at characterizing the fate of iron oxide nanoparticles used in cell tracking studies and the role of macrophages in SPIO metabolism.In vivo MRI cell tracking of SPIO positive 4T1 breast cancer cells revealed a quick loss of T2* contrast after injection...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454771/next-generation-superparamagnetic-iron-oxide-nanoparticles-for-cancer-theranostics
#20
REVIEW
Kai Li, Hossein Nejadnik, Heike E Daldrup-Link
Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices...
April 26, 2017: Drug Discovery Today
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