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https://www.readbyqxmd.com/read/28748623/photoacoustic-guided-surgery-with-indocyanine-green-coated-superparamagnetic-iron-oxide-nanoparticle-clusters
#1
Jayesh P Thawani, Ahmad Amirshaghaghi, Lesan Yan, Joel M Stein, Jessica Liu, Andrew Tsourkas
A common cause of local tumor recurrence in brain tumor surgery results from incomplete surgical resection. Adjunctive technologies meant to facilitate gross total resection have had limited efficacy to date. Contrast agents used to delineate tumors preoperatively cannot be easily or accurately used in the real-time operative setting. Although multimodal imaging contrast agents are developed to help the surgeon discern tumor from normal tissue in the operating room, these contrast agents are not readily translatable...
July 27, 2017: Small
https://www.readbyqxmd.com/read/28654377/image-based-analysis-of-tumor-localization-after-intra-arterial-delivery-of-technetium-99m-labeled-spio-using-spect-ct-and-mri
#2
In Joon Lee, Ji Yong Park, Young-Il Kim, Yun-Sang Lee, Jae Min Jeong, Jaeil Kim, Euishin Edmund Kim, Keon Wook Kang, Dong Soo Lee, Seonji Jeong, Eun Jeong Kim, Young Il Kim, Jin Wook Chung
The aim of this study is to evaluate the localization of (99m)Tc-labeled dextran-coated superparamagnetic iron oxide (SPIO) nanoparticles to the liver tumor using image-based analysis. We delivered (99m)Tc-SPIO intravenously or intra-arterially (IA) with/without Lipiodol to compare the tumor localization by gamma scintigraphy, single-photon emission computed tomography (SPECT), and magnetic resonance imaging (MRI) in a rabbit liver tumor. The gamma and SPECT image-based analysis shows that the uptake ratio of the tumor to the normal liver parenchyma is highest after delivery of (99m)Tc-SPIO with Lipiodol IA and that well correlates with the trend of the signal decrease in the liver MRIs...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28652736/magnetic-alginate-microspheres-detected-by-mri-fabricated-using-microfluidic-technique-and-release-behavior-of-encapsulated-dual-drugs
#3
Qin Wang, Shanshan Liu, Fan Yang, Lu Gan, Xiangliang Yang, Yajiang Yang
Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28644801/magnetic-particle-imaging-for-quantification-of-vascular-stenoses-a-phantom-study
#4
S Herz, P Vogel, T Kampf, M A Ruckert, S Veldhoen, V C Behr, T A Bley
Magnetic particle imaging (MPI) is a promising new tomographic imaging method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim of this study was to investigate the potential of MPI to quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees of stenosis (0 %, 25 %, 50 %, 75 % and 100 %) were scanned in a custom-built MPI scanner (in-plane resolution: ~ 1-1.5 mm, field of view: 65 × 29 × 29 mm3)...
June 21, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28638483/thermoacoustic-imaging-and-therapy-guidance-based-on-ultra-short-pulsed-microwave-pumped-thermoelastic-effect-induced-with-superparamagnetic-iron-oxide-nanoparticles
#5
Liewei Wen, Sihua Yang, Junping Zhong, Quan Zhou, Da Xing
Multifunctional nanoparticle-mediated imaging and therapeutic techniques are promising modalities for accurate localization and targeted treatment of cancer in clinical settings. Thermoacoustic (TA) imaging is highly sensitive to detect the distribution of water, ions or specific nanoprobes and provides excellent resolution, good contrast and superior tissue penetrability. TA therapy is a potential non-invasive approach for the treatment of deep-seated tumors. In this study, human serum albumin (HSA)-functionalized superparamagnetic iron oxide nanoparticle (HSA-SPIO) is used as a multifunctional nanoprobe with clinical application potential for MRI, TA imaging and treatment of tumor...
2017: Theranostics
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#6
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28591953/-magnetic-resonance-imaging-tracing-the-biodistribution-of-spio-shrna-molecular-probe-in-vivo
#7
Xiao-Lin Deng, Xiao-Feng Wu, Rui-Kun Liao, Dan-Ni Zeng, Ming Wen, Shao-Lin Li
OBJECTIVES: To investigate the biodistribution of superparamagnetic iron oxide (SPIO)-shRNA molecular probe by magnetic resonance imaging (MRI) in vivo. METHODS: Six New Zealand white rabbits were injected intravenously with SPIO-shRNA molecular probe (9.6 mg Fe/kg) via ear edge vein. The blood samples were collected to analyse the pharmacokinetic parameters through measuring the iron content by atomic absorption spectrometry (AAS) method at 30 min before and 1 min, 3 min, 5 min, 10 min, 15 min, 30 min and at 1, 2, 3, 6, 12, and 24 h after the injection...
July 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28566744/mri-tracking-of-autologous-pancreatic-progenitor-derived-insulin-producing-cells-in-monkeys
#8
Chunlin Zou, Yi Lu, Xiahong Teng, Shuyan Wang, Xiaoting Sun, Fen Huang, Guannan Shu, Xin Huang, Hongwei Guo, Zhiguo Chen, Jian Zhang, Yu Alex Zhang
Insulin-producing cells (IPCs) derived from a patient's own stem cells offer great potential for autologous transplantation in diabetic patients. However, the limited survival of engrafted cells remains a bottleneck in the application of this strategy. The present study aimed to investigate whether nanoparticle-based magnetic resonance (MR) tracking can be used to detect the loss of grafted stem cell-derived IPCs in a sensitive and timely manner in a diabetic monkey model. Pancreatic progenitor cells (PPCs) were isolated from diabetic monkeys and labeled with superparamagnetic iron oxide nanoparticles (SPIONs)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28539289/-effect-of-superparamagnetic-iron-oxide-on-differentiation-of-rat-bone-marrow-stem-cells-into-chondrocytes-in-vitro
#9
Fang Jiang, Ji-Jie Xiao, Yuan-Ting Lu, Wei Li, Yu-Wen Duan, Zong-Hai Sheng, Shao-Lin Li
OBJECTIVE: To observe the effect of superparamagnetic iron oxide (SPIO) on the differentiation of rat bone marrow stem cells (BMSCs) into chondrocytes in vitro and explore the possible mechanism. METHODS: CCK8 assay was performed to examine the cytotoxicity of SPIO (1 and 5 µg/mL) on cultured SD rat BMSCs. Prussian blue staining and fluorescence excitation assay were used to assess the binding of the SPIO to BMSCs after the cells had been cultured in chondrocytes-induced medium in the presence of SPIO (1 and 5 µg/mL) for 9 days...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28492491/magnetic-cationic-amylose-nanoparticles-used-to-deliver-survivin-small-interfering-rna-for-gene-therapy-of-hepatocellular-carcinoma-in-vitro
#10
Zhuo Wu, Xiao-Lin Xu, Jun-Zhao Zhang, Xu-Hong Mao, Ming-Wei Xie, Zi-Liang Cheng, Lie-Jing Lu, Xiao-Hui Duan, Li-Ming Zhang, Jun Shen
Amylose is a promising nanocarrier for gene delivery in terms of its good biocompatibility and high transfection efficiency. Small interfering RNA against survivin (survivin-siRNA) can cause tumor apoptosis by silencing a hepatocellular carcinoma (HCC)-specific gene at the messenger RNA level. In this study, we developed a new class of folate-functionalized, superparamagnetic iron oxide (SPIO)-loaded cationic amylose nanoparticles to deliver survivin-siRNA to HCC cells. The cellular uptake of nanocomplexes, cytotoxicity, cell apoptosis, and gene suppression mediated by siRNA-complexed nanoparticles were tested...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28467814/contribution-of-macrophages-in-the-contrast-loss-in-iron-oxide-based-mri-cancer-cell-tracking-studies
#11
Pierre Danhier, Gladys Deumer, Nicolas Joudiou, Caroline Bouzin, Philippe Levêque, Vincent Haufroid, Bénédicte F Jordan, Olivier Feron, Pierre Sonveaux, Bernard Gallez
Magnetic resonance imaging (MRI) cell tracking of cancer cells labeled with superparamagnetic iron oxides (SPIO) allows visualizing metastatic cells in preclinical models. However, previous works showed that the signal void induced by SPIO on T2(*)-weighted images decreased over time. Here, we aim at characterizing the fate of iron oxide nanoparticles used in cell tracking studies and the role of macrophages in SPIO metabolism.In vivo MRI cell tracking of SPIO positive 4T1 breast cancer cells revealed a quick loss of T2* contrast after injection...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454771/next-generation-superparamagnetic-iron-oxide-nanoparticles-for-cancer-theranostics
#12
REVIEW
Kai Li, Hossein Nejadnik, Heike E Daldrup-Link
Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively studied for the development of contrast agents in MRI. First-generation SPIO nanoparticles had diagnostic capabilities only, whereas a new generation of SPIO nanoparticle has multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. In particular, polymer-coated theranostic SPIO nanoparticles have enjoyed increasing attention as a result of good biocompatibility, biodegradability and versatile functionality endowed by polymeric matrices...
April 26, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28447974/3d-whole-heart-myocardial-tissue-analysis
#13
Hans Thijs Van den Broek, Leon De Jong, Pieter A Doevendans, Steven A J Chamuleau, Frebus J Van Slochteren, René Van Es
Cardiac regenerative therapies aim to protect and repair the injured heart in patients with ischemic heart disease. By injecting stem cells or other biologicals that enhance angio- or vasculogenesis into the infarct border zone (IBZ), tissue perfusion is improved, and the myocardium can be protected from further damage. For maximum therapeutic effect, it is hypothesized that the regenerative substance is best delivered to the IBZ. This requires accurate injections and has led to the development of new injection techniques...
April 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28416757/theranostic-imaging-of-liver-cancer-using-targeted-optical-mri-dual-modal-probes
#14
Qingshan Chen, Wenting Shang, Chaoting Zeng, Kun Wang, Xiaoyuan Liang, Chongwei Chi, Xiao Liang, Jian Yang, Chihua Fang, Jie Tian
The accurate preoperative detection and intraoperative navigation afforded by imaging techniques have had significant impact on the success of liver cancer surgeries. However, it is difficult to achieve satisfactory performance in both diagnosis and surgical treatment processes using any single modality imaging method. Here, we report the synthesis and characteristics of a novel dual-modality magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) probe and verify its feasibility in nude mouse models with liver cancer...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396973/seeing-spios-directly-in-vivo-with-magnetic-particle-imaging
#15
Bo Zheng, Elaine Yu, Ryan Orendorff, Kuan Lu, Justin J Konkle, Zhi Wei Tay, Daniel Hensley, Xinyi Y Zhou, Prashant Chandrasekharan, Emine U Saritas, Patrick W Goodwill, John D Hazle, Steven M Conolly
Magnetic particle imaging (MPI) is a new molecular imaging technique that directly images superparamagnetic tracers with high image contrast and sensitivity approaching nuclear medicine techniques-but without ionizing radiation. Since its inception, the MPI research field has quickly progressed in imaging theory, hardware, tracer design, and biomedical applications. Here, we describe the history and field of MPI, outline pressing challenges to MPI technology and clinical translation, highlight unique applications in MPI, and describe the role of the WMIS MPI Interest Group in collaboratively advancing MPI as a molecular imaging technique...
April 10, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28298928/biological-characteristics-of-fluorescent-superparamagnetic-iron-oxide-labeled-human-dental-pulp-stem-cells
#16
Liang Ma, Ming-Wei Li, Yu Bai, Hui-Hui Guo, Sheng-Chao Wang, Qing Yu
Tracking transplanted stem cells is necessary to clarify cellular properties and improve transplantation success. In this study, we investigate the effects of fluorescent superparamagnetic iron oxide particles (SPIO) (Molday ION Rhodamine-B™, MIRB) on biological properties of human dental pulp stem cells (hDPSCs) and monitor hDPSCs in vitro and in vivo using magnetic resonance imaging (MRI). Morphological analysis showed that intracellular MIRB particles were distributed in the cytoplasm surrounding the nuclei of hDPSCs...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28280341/a-facile-method-to-prepare-superparamagnetic-iron-oxide-and-hydrophobic-drug-encapsulated-biodegradable-polyurethane-nanoparticles
#17
Kuo-Wei Cheng, Shan-Hui Hsu
Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28280327/biocompatibility-of-very-small-superparamagnetic-iron-oxide-nanoparticles-in-murine-organotypic-hippocampal-slice-cultures-and-the-role-of-microglia
#18
Martin Pohland, Robert Glumm, Frank Wiekhorst, Jürgen Kiwit, Jana Glumm
Superparamagnetic iron oxide nanoparticles (SPIO) are applied as contrast media for magnetic resonance imaging (MRI) and treatment of neurologic diseases despite the fact that important information concerning their local interactions is still lacking. Due to their small size, SPIO have great potential for magnetically labeling different cell populations, facilitating their MRI tracking in vivo. Before SPIO are applied, however, their effect on cell viability and tissue homoeostasis should be studied thoroughly...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28279919/active-targeting-theranostic-iron-oxide-nanoparticles-for-mri-and-magnetic-resonance-guided-focused-ultrasound-ablation-of-lung-cancer
#19
Zhongling Wang, Ruirui Qiao, Na Tang, Ziwei Lu, Han Wang, Zaixian Zhang, Xiangdong Xue, Zhongyi Huang, Siruo Zhang, Guixiang Zhang, Yuanpei Li
Despite its great promise in non-invasive treatment of cancers, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is currently limited by the insensitivity of magnetic resonance imaging (MRI) for visualization of small tumors, low efficiency of in vivo ultrasonic energy deposition, and damage to surrounding tissues. We hereby report the development of an active targeting nano-sized theranostic superparamagnetic iron oxide (SPIO) platform for significantly increasing the imaging sensitivity and energy deposition efficiency using a clinical MRgFUS system...
May 2017: Biomaterials
https://www.readbyqxmd.com/read/28275562/a-comprehensive-literatures-update-of-clinical-researches-of-superparamagnetic-resonance-iron-oxide-nanoparticles-for-magnetic-resonance-imaging
#20
REVIEW
Yì Xiáng J Wáng, Jean-Marc Idée
This paper aims to update the clinical researches using superparamagnetic iron oxide (SPIO) nanoparticles as magnetic resonance imaging (MRI) contrast agent published during the past five years. PubMed database was used for literature search, and the search terms were (SPIO OR superparamagnetic iron oxide OR Resovist OR Ferumoxytol OR Ferumoxtran-10) AND (MRI OR magnetic resonance imaging). The literature search results show clinical research on SPIO remains robust, particularly fuelled by the approval of ferumoxytol for intravenously administration...
February 2017: Quantitative Imaging in Medicine and Surgery
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