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https://www.readbyqxmd.com/read/28059427/evaluation-of-peg-coated-iron-oxide-nanoparticles-as-blood-pool-tracers-for-preclinical-magnetic-particle-imaging
#1
A P Khandhar, P Keselman, S J Kemp, R M Ferguson, P W Goodwill, S M Conolly, K M Krishnan
Superparamagnetic iron oxide (SPIO) nanoparticles with optimized and well-characterized properties are critical for Magnetic Particle Imaging (MPI). MPI is a novel in vivo imaging modality that promises to integrate the speed of X-ray CT, safety of MRI and sensitivity of PET. Since SPIOs are the source of MPI signal, both the core and surface properties must be optimized to enable efficient in vivo imaging with pharmacokinetics tailored for specific imaging applications. Existing SPIOs like Resovist (ferucarbotran) provide a suboptimal MPI signal, and further limit MPI's in vivo utility due to rapid systemic clearance...
January 6, 2017: Nanoscale
https://www.readbyqxmd.com/read/28056877/antenatal-care-trial-interventions-a-systematic-scoping-review-and-taxonomy-development-of-care-models
#2
Andrew Symon, Jan Pringle, Soo Downe, Vanora Hundley, Elaine Lee, Fiona Lynn, Alison McFadden, Jenny McNeill, Mary J Renfrew, Mary Ross-Davie, Edwin van Teijlingen, Heather Whitford, Fiona Alderdice
BACKGROUND: Antenatal care models vary widely around the world, reflecting local contexts, drivers and resources. Randomised controlled trials (RCTs) have tested the impact of multi-component antenatal care interventions on service delivery and outcomes in many countries since the 1980s. Some have applied entirely new schemes, while others have modified existing care delivery approaches. Systematic reviews (SRs) indicate that some specific antenatal interventions are more effective than others; however the causal mechanisms leading to better outcomes are poorly understood, limiting implementation and future research...
January 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28056102/magnetic-particle-imaging-mpi-experimental-quantification-of-vascular-stenosis-using-stationary-stenosis-phantoms
#3
Sarah Vaalma, Jürgen Rahmer, Nikolaos Panagiotopoulos, Robert L Duschka, Jörn Borgert, Jörg Barkhausen, Florian M Vogt, Julian Haegele
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, high signal-to-noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs). Because of that, MPI is proposed to be a promising future method for cardiovascular imaging. Here, an interesting application may be the quantification of vascular pathologies like stenosis by utilizing the proportionality of the SPIO concentration and the MPI signal strength...
2017: PloS One
https://www.readbyqxmd.com/read/28044245/mri-detection-of-endothelial-cell-inflammation-using-targeted-superparamagnetic-particles-of-iron-oxide-spio
#4
Joyce M S Chan, Maggie S H Cheung, Richard G J Gibbs, Kishore K Bhakoo
BACKGROUND: There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron oxide (SPIO) as a magnetic resonance imaging (MRI) probe for detecting inflamed endothelial cells. METHODS: The in vitro study consists of the characterisation and detection of inflammatory markers on activated endothelial cells by immunocytochemistry and MRI using biotinylated anti-P-selectin and anti-VCAM-1 (vascular cell adhesion molecule 1) antibody and streptavidin conjugated SPIO...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28040662/development-and-application-of-micro-polysaccharide-drug-carriers-incorporating-doxorubicin-and-superparamagnetic-iron-oxide-for-bimodality-treatment-of-hepatocellular-carcinoma
#5
Sung-Ling Tang, Meng-Yi Bai, Jyun-Yi Wang, Po-Da Hong
In this study, we demonstrated a novel polyelectrolyte microparticle, doxorubicin(DOX)-superparamagnetic iron oxide (SPIO)-chondroitin sulfate (CS)/chitosan (CHI)microparticles (MPs), as a drug delivery system for hepatic cancer treatment. We also investigated the properties of these microparticles through composition determination, formulation tests, in vitro study, and in vivo study. The results showed that our DOX-SPIO-CS/CHI MPs had an average diameter of 1.43±0.54μm and exhibited a spherical shape. The encapsulation efficiency of this drug carrier was approximately 31±8...
December 23, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28024568/study-and-evaluation-of-nucleolin-targeted-delivery-of-magnetic-plga-peg-nanospheres-loaded-with-doxorubicin-to-c6-glioma-cells-compared-with-low-nucleolin-expressing-l929-cells
#6
Jafar Mosafer, Manouchehr Teymouri, Khalil Abnous, Mohsen Tafaghodi, Mohammad Ramezani
Magnetic nanoparticulate systems based on polymeric materials such as poly (lactic-co-glycolic acid) (PLGA(1)) are being studied for their potential applications in targeted therapy and imaging of malignant tumors. In the current study, superparamagnetic iron oxide nanocrystals (SPIONs(2)) and doxorubicin (Dox(3)) were entrapped in the PLGA-based nanoparticles via a modified multiple emulsion solvent evaporation method. Furthermore, SPIO/Dox-NPs(4) were conjugated to anti-nucleolin AS1411 aptamer (Apt(5)) and their targeting ability was investigated in high nucleolin-expressing C6 glioma cells compared to low nucleolin-expressing L929 cells...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28012991/in-vitro-and-in-vivo-evaluation-of-anti-nucleolin-targeted-magnetic-plga-nanoparticles-loaded-with-doxorubicin-as-a-theranostic-agent-for-enhanced-targeted-cancer-imaging-and-therapy
#7
Jafar Mosafer, Khalil Abnous, Mohsen Tafaghodi, Ahad Mokhtarzadeh, Mohammad Ramezani
A superparamagnetic iron oxide nanoparticles (SPIONs(1))/doxorubicin (Dox(2)) co-loaded poly(lactic-co-glycolic acid) (PLGA(3))-based nanoparticles targeted with AS1411 aptamer (Apt(4)) against murine C26 colon carcinoma cells is successfully developed via a modified multiple emulsion solvent evaporation method for theranostic purposes. The mean size of SPIO/Dox-NPs(5) (NPs) was 130 nm with a narrow particle size distribution and Dox loading of 3.0%. The SPIO loading of 16.0% and acceptable magnetic properties are obtained and analyzed using thermogravimetric and vibration simple magnetometer analysis, respectively...
December 21, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27991598/using-anti-poly-ethylene-glycol-bioparticles-for-the-quantitation-of-pegylated-nanoparticles
#8
Yuan-Chin Hsieh, Ta-Chun Cheng, Hsin-Ell Wang, Jia-Je Li, Wen-Wei Lin, Chien-Chiao Huang, Chih-Hung Chuang, Yeng-Tseng Wang, Jaw-Yuan Wang, Steve R Roffler, Kuo-Hsiang Chuang, Tian-Lu Cheng
Attachment of polyethylene glycol (PEG) molecules to nanoparticles (PEGylation) is a widely-used method to improve the stability, biocompatibility and half-life of nanomedicines. However, the evaluation of the PEGylated nanomedicine pharmacokinetics (PK) requires the decomposition of particles and purification of lead compounds before analysis by high performance liquid chromatography (HPLC), mass spectrometry, etc. Therefore, a method to directly quantify un-decomposed PEGylated nanoparticles is needed. In this study, we developed anti-PEG bioparticles and combined them with anti-PEG antibodies to generate a quantitative enzyme-linked immunosorbent assay (ELISA) for direct measurement of PEGylated nanoparticles without compound purification...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977143/magnetite-nanoparticles-for-stem-cell-labeling-with-high-efficiency-and-long-term-in-vivo-tracking
#9
Noelia Guldris, Bárbara Argibay, Juan Gallo, Ramón Iglesias-Rey, Enrique Carbó-Argibay, Yury V Kolen'ko, Francisco Campos, Tomás Sobrino, Laura M Salonen, Manuel Bañobre-López, José Castillo, José Rivas
Superparamagnetic iron oxide nanoparticles (SPIO-PAA), ultrasmall iron oxide nanoparticles (USPIO-PAA), and glucosamine-modified iron oxide nanoparticles (USPIO-PAA-GlcN) were studied as mesenchymal stem cell (MSCs) labels for cell tracking applications by magnetic resonance imaging (MRI). Pronounced differences were found in the labeling performance of the three samples in terms of cellular dose and labeling efficiency. In combination with polylysine, SPIO-PAA showed nonhomogeneous cell internalization, while for USPIO-PAA no uptake was found...
December 15, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27943555/spio-enhanced-mri-is-useful-in-predicting-malignant-potential-of-vascular-transformation-of-hypointense-hypovascular-nodules-on-gd-eob-dtpa-enhanced-mri
#10
Yoshiaki Tanaka, Takahide Nakazawa, Tomoyoshi Inoue, Keiko Yamane, Kousuke Kubota, Haruki Uojima, Juichi Takada, Yusuke Okuwaki, Hisashi Hidaka, Akitaka Shibuya, Shigehiro Kokubu, Keiji Matsunaga, Wasaburo Koizumi
AIM: To examine whether superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) can be used to assess the malignant potential of hepatic hypovascular nodules showing hypointensity during the hepatobiliary phase (HBP) on gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI. METHODS: The study included 42 patients with chronic liver disease who had small hypovascular nodules (5-15 mm) showing hypointensity during the HBP on Gd-EOB-DTPA-enhanced MRI. SPIO-enhanced T2-weighted MRI analyzed whether the signal intensity of each nodule was high...
December 11, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27935574/europium-doping-of-superparamagnetic-iron-oxide-nanoparticles-enables-their-detection-by-fluorescence-microscopy-and-for-quantitative-analytics
#11
Yuske Kobayashi, Ralf Hauptmann, Harald Kratz, Monika Ebert, Susanne Wagner, Matthias Taupitz
BACKGROUND: Pharmacokinetic studies and histological detection of superparamagnetic iron oxide nanoparticles (SPIO) in biomedical research are limited due to a high iron background especially in pathological tissues. OBJECTIVE: The suitability of doping the iron oxide cores of SPIO with europium (Eu) was tested for improved histologic detection and for quantitative analysis without changing their properties as probes for magnetic resonance imaging (MRI). A special variant of SPIO, so called very small superparamagnetic iron oxide nanoparticles (VSOP), was used for this approach...
December 2, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27902468/synthesis-of-a-cell-penetrating-peptide-modified-superparamagnetic-iron-oxide-and-mri-detection-of-bladder-cancer
#12
Chen Ding, Kaijie Wu, Weiyi Wang, Zhenfeng Guan, Lei Wang, Xinyang Wang, Rong Wang, Li Liu, Jinhai Fan
Bladder cancer is the most common malignancy of the urinary tract for which the accurate measurement of minimal residual disease is critical to treatment and determining prognosis. Although cystoscope examination and voided urine cytology remain the current standard of care for detecting residual disease, these approaches are limited by mechanical trauma and lack sensitivity. To develop a new accurate noninvasive method, we developed a novel contrast agent where the surface of superparamagnetic iron oxide (SPIO) nanoparticles is functionalized with a bladder cancer-specific fluorescein isothiocyanate (FITC) labeled cell penetrating peptide (CPP)-polyarginine peptides (R11) for active targeting and imaging...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887719/leucine-rich-repeat-containing-g-protein-coupled%C3%A2-receptor%C3%A2-5-positive%C3%A2-cells%C3%A2-in-the-endometrial-stem-cell-niche
#13
Irene Cervelló, Claudia Gil-Sanchis, Xavier Santamaría, Amparo Faus, Julia Vallvé-Juanico, Patricia Díaz-Gimeno, Oriana Genolet, Antonio Pellicer, Carlos Simón
OBJECTIVE: To study, isolate and characterize leucine-rich repeat-containing heterotrimeric guanine nucleotide-binding protein-coupled receptor 5 (LGR5)-positive cells from human endometrium to determine their functional relevance. DESIGN: Prospective experimental animal study. SETTING: University research laboratories. ANIMAL(S): Nonobese diabetic mice (NOD-SCID) (strain code 394; NOD.CB17-Prkdc(scid)/NcrCrl). INTERVENTION(S): Human LGR5(+) cells were labeled with superparamagnetic iron oxide nanoparticles (SPIOs) and injected under the kidney capsule in immunocompromised mice...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27865025/mr-targeted-imaging-for-the-expression-of-tenascin-c-in-myocardial-infarction-in-vivo
#14
Jiacheng Song, Jing Yu, Yan Li, Shanshan Lu, Zhanlong Ma, Haibin Shi
PURPOSE: To investigate the presence of viable myocardium in mice with acute myocardial infarction (MI) using a molecular targeted probe. MATERIALS AND METHODS: Super paramagnetic iron oxide (SPIO) nanoparticles and tenascin-C antibody were conjugated as an MRI probe. Fifteen mice with infarction were injected with SPIO-anti-tenascin-C (3 days [d], 5d, 7d after infarction; n = 5 for each group). Another five mice with infarction (5d, n = 5) were injected with SPIO for comparison...
November 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27846432/functionalized-nanoparticles-enable-tracking-the-rapid-entry-and-release-of-doxorubicin-in-human-pancreatic-cancer-cells
#15
Maheshika P Arachchige, Suvra S Laha, Akshata R Naik, Kenneth T Lewis, Ratna Naik, Bhanu P Jena
Efficient drug delivery is critical to therapy. Using electron microscopy, X-ray, and light microscopy, we have characterized functionalized superparamagnetic iron oxide (SPIO) nanoparticles, and determined their ability for rapid entry and release of the cancer drug doxorubicin in human pancreatic cancer cells. Dextran-coated SPIO nanoparticle ferrofluid, functionalized with the red-autofluorescing doxorubicin and the green-fluorescent dye fluorescein isothiocyanate as a reporter, enables tracking the intracellular nanoparticle transport and drug release...
October 29, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/27834642/magnetic-particle-imaging-a-resovist-based-marking-technology-for-guide-wires-and-catheters-for-vascular-interventions
#16
Julian Haegele, Nikolaos Panagiotopoulos, Sjef Cremers, Ju Rgen Rahmer, Jochen Franke, Robert L Duschka, Sarah Vaalma, Michael Heidenreich, Jo Rn Borgert, Paul Borm, Jo Rg Barkhausen, Florian M Vogt
Magnetic particle imaging (MPI) is able to provide high temporal and good spatial resolution, high signal to noise ratio and sensitivity. Furthermore, it is a truly quantitative method as its signal strength is proportional to the concentration of its tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over a wide range practically relevant concentrations. Thus, MPI is proposed as a promising future method for guidance of vascular interventions. To implement this, devices such as guide wires and catheters have to be discernible in MPI, which can be achieved by coating already commercially available devices with SPIOs...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27811826/observations-on-the-biology-of-afrotropical-hesperiidae-lepidoptera-%C3%A2-with-particular-reference-to-kenya-part-10-pyrginae-carcharodini
#17
Matthew J W Cock
Partial life histories are presented for Spialia kituina (Karsch), S. spio (Linnaeus), S. diomus (Hopffer), S. colotes transvaaliae (Trimen), S. dromus (Plötz), S. ploetzi (Aurivillius), S. zebra bifida Higgins and Gomalia elma elma (Trimen). All feed on species of Malvaceae. An earlier record from Kenya of Melhania velutina as the food plant of S. depauperata depauperata (Strand) was based on a misidentification and there are no known records of the food plant of this subspecies. Spialia ferax (Wallengren) stat...
October 5, 2016: Zootaxa
https://www.readbyqxmd.com/read/27807502/near-infrared-dye-loaded-magnetic-nanoparticles-as-photoacoustic-contrast-agent-for-enhanced-tumor-imaging
#18
Chuang Gao, Zi-Jian Deng, Dong Peng, Yu-Shen Jin, Yan Ma, Yan-Yan Li, Yu-Kun Zhu, Jian-Zhong Xi, Jie Tian, Zhi-Fei Dai, Chang-Hui Li, Xiao-Long Liang
Objective: Photoacoustic (PA) tomography (PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human body. Methods: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[methoxy (polyethylene glycol)] (DSPE-PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles (NPs) loaded with indocyanine green (ICG)...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27807499/nanomaterials-incorporated-ultrasound-contrast-agents-for-cancer-theranostics
#19
Lei Fu, Heng-Te Ke
Nanotechnology provides various nanomaterials with tremendous functionalities for cancer diagnostics and therapeutics. Recently, theranostics has been developed as an alternative strategy for efficient cancer treatment through combination of imaging diagnosis and therapeutic interventions under the guidance of diagnostic results. Ultrasound (US) imaging shows unique advantages with excellent features of real-time imaging, low cost, high safety and portability, making US contrast agents (UCAs) an ideal platform for construction of cancer theranostic agents...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27782005/a-handheld-spio-based-sentinel-lymph-node-mapping-device-using-differential-magnetometry
#20
S Waanders, M Visscher, R R Wildeboer, T O B Oderkerk, H J G Krooshoop, B Ten Haken
Sentinel lymph node biopsy has become a staple tool in the diagnosis of breast cancer. By replacing the morbidity-plagued axillary node clearance with removing only those nodes most likely to contain metastases, it has greatly improved the quality of life of many breast cancer patients. However, due to the use of ionizing radiation emitted by the technetium-based tracer material, the current sentinel lymph node biopsy has serious drawbacks. Most urgently, the reliance on radioisotopes limits the application of this procedure to small parts of the developed world, and it imposes restrictions on patient planning and hospital logistics...
November 21, 2016: Physics in Medicine and Biology
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