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https://www.readbyqxmd.com/read/28743036/recist-response-and-variation-of-circulating-tumour-cells-in-phase-1-trials-a-prospective-multicentric-study
#1
Christophe Massard, Isabelle Borget, Françoise Farace, Sandrine Aspeslagh, Marie-Cécile Le Deley, Christophe Le Tourneau, François-Clement Bidard, Jean-Yves Pierga, Veronique Dieras, Paul Hofman, Jean-Philippe Spano, Charles Ferte, Ludovic Lacroix, Jean-Charles Soria
BACKGROUND: Circulating tumour cell (CTC) counting could be a new biomarker for better evaluation of tumour response to molecules tested in phase I trials. PATIENTS AND METHODS: Consenting patients with advanced metastatic cancer referred to various phase I units were enrolled prospectively in this study. CTCs from 7.5 ml of whole blood drawn at baseline and after starting experimental therapy were counted using the CellSearch system, and tumour response was assessed using RECIST 1...
July 22, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28742723/supraglottic-atomization-of-surfactant-in-spontaneously-breathing-lambs-receiving-continuous-positive-airway-pressure
#2
Ilaria Milesi, David G Tingay, Anna Lavizzari, Federico Bianco, Emanuela Zannin, Paolo Tagliabue, Fabio Mosca, Maria Luisa Ventura, Anushi Rajapaksa, Elizabeth J Perkins, Don Black, Marco Di Castri, Magdy Sourial, Gerhard Pohlmann, Raffaele L Dellaca'
OBJECTIVES: To determine the short-term tolerance, efficacy, and lung deposition of supraglottic atomized surfactant in spontaneously breathing lambs receiving continuous positive airway pressure. DESIGN: Prospective, randomized animal study. SETTING: Animal research laboratory. SUBJECTS: Twenty-two preterm lambs on continuous positive airway pressure (132 ± 1 d gestational age). INTERVENTIONS: Animals receiving continuous positive airway pressure via binasal prongs at 8 cm H2O were randomized to receive atomized surfactant at approximately 60-minute of life (atom; n = 15) or not (control; n = 7)...
July 22, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28742456/dietary-fat-intake-and-lung-cancer-risk-a-pooled-analysis
#3
Jae Jeong Yang, Danxia Yu, Yumie Takata, Stephanie A Smith-Warner, William Blot, Emily White, Kim Robien, Yikyung Park, Yong-Bing Xiang, Rashmi Sinha, DeAnn Lazovich, Meir Stampfer, Rosario Tumino, Dagfinn Aune, Kim Overvad, Linda Liao, Xuehong Zhang, Yu-Tang Gao, Mattias Johansson, Walter Willett, Wei Zheng, Xiao-Ou Shu
Purpose Dietary fat may play a role in lung carcinogenesis. Findings from epidemiologic studies, however, remain inconsistent. In this pooled analysis of 10 prospective cohort studies from the United States, Europe, and Asia, we evaluated the associations of total and specific types of dietary fat with lung cancer risk. Methods Cox regression was used to estimate hazard ratios (HRs) and 95% CIs in each cohort. Study-specific risk estimates were pooled by random- or fixed-effects meta-analysis. The first 2 years of follow-up were excluded to address potential influence of preclinical dietary changes...
July 25, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28741732/lung-cancer-short-term-reproducibility-of-intravoxel-incoherent-motion-parameters-and-apparent-diffusion-coefficient-at-3t
#4
Jianqin Jiang, Jianbin Yin, Lei Cui, Xiaowen Gu, Rongfang Cai, Shenchu Gong, Yiming Xu, Hang Ma, Jian Mao
PURPOSE: To prospectively evaluate the short-term reproducibility of intravoxel incoherent motion (IVIM) parameters and apparent diffusion coefficient (ADC) in lung cancer patients. MATERIALS AND METHODS: In all, 50 patients (50 lesions) underwent free-breathing diffusion-weighted imaging (DWI) (b = 0, 300, 800 s/mm(2) ) and IVIM (10 b-values, 0-1000 s/mm(2) ) scans twice (0.5-1-hour interval) at 3T. Regions of interests (ROIs) were drawn on ADC maps and IVIM images to derive the mean ADC value and IVIM parameters D, D*, and f...
July 25, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28741176/safety-and-feasibility-of-exercise-interventions-in-patients-with-advanced-cancer-a-systematic-review
#5
REVIEW
Reginald Heywood, Alexandra L McCarthy, Tina L Skinner
GOALS OF WORK: The beneficial effects of exercise in cancer patients are reasonably well-established, although research in this field has predominantly investigated cancer patients in the earlier stages of disease. However, the most recent evidence surrounding exercise interventions in advanced cancer populations has yet to be systematically evaluated. This review critically analyses the safety and feasibility of exercise interventions in patients with advanced cancer. METHODS: All randomised, non-randomised and prospective observational trials of exercise training interventions in patients with advanced cancer were included...
July 25, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28740898/priority-driven-plan-optimization-in-locally-advanced-lung-patients-based-on-perfusion-spect-imaging
#6
Martha M Matuszak, Charles Matrosic, David Jarema, Daniel L McShan, Matthew H Stenmark, Dawn Owen, Shruti Jolly, Feng-Ming Spring Kong, Randall K Ten Haken
PURPOSE: Limits on mean lung dose (MLD) allow for individualization of radiation doses at safe levels for patients with lung tumors. However, MLD does not account for individual differences in the extent or spatial distribution of pulmonary dysfunction among patients, which leads to toxicity variability at the same MLD. We investigated dose rearrangement to minimize the radiation dose to the functional lung as assessed by perfusion single photon emission computed tomography (SPECT) and maximize the target coverage to maintain conventional normal tissue limits...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740676/segmentectomy-versus-lobectomy-for-stage-i-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis
#7
Benedetta Bedetti, Luca Bertolaccini, Raffaele Rocco, Joachim Schmidt, Piergiorgio Solli, Marco Scarci
BACKGROUND: In recent years, many factors have revamped the interest in segmentectomies as preferred procedure for stage I non-small cell lung cancer (NSCLC). The aim of this systematic review and meta-analysis is to compare the outcomes of segmentectomy versus lobectomy regarding overall survival (OS) in the surgical treatment of stage I NSCLC, as stated in the conclusions of the largest studies conducted in this field and reported to date. METHODS: The searching strategy was developed in EMBASE, MEDLINE and Cochrane CENTRAL from 1990 until December 2016...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740675/feasibility-of-four-arm-robotic-lobectomy-as-solo-surgery-in-patients-with-clinical-stage-i-lung-cancer
#8
Seong Yong Park, Jee Won Suh, Kyoung Sik Narm, Chang Young Lee, Jin Gu Lee, Hyo Chae Paik, Kyoung Young Chung, Dae Joon Kim
BACKGROUND: This study was performed to investigate the feasibility of four-arm robotic lobectomy (FARL) as a solo surgical technique in patients with non-small cell lung cancer (NSCLC). Early outcome and long-term survival of FARL were compared with those of video-assisted thoracoscopic lobectomy (VATL). METHODS: Prospective enrollment of patients with clinical stage I NSCLC undergoing FARL or VATL (20 patients in each group) was planned. Interim analysis for early postoperative outcome was performed after the initial 10 cases in each group...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740674/does-the-usage-of-digital-chest-drainage-systems-reduce-pleural-inflammation-and-volume-of-pleural-effusion-following-oncologic-pulmonary-resection-a-prospective-randomized-trial
#9
Michèle De Waele, John Agzarian, Waël C Hanna, Colin Schieman, Christian J Finley, Joseph Macri, Laura Schneider, Terri Schnurr, Forough Farrokhyar, Katherine Radford, Parameswaran Nair, Yaron Shargall
BACKGROUND: Prolonged air leak and high-volume pleural drainage are the most common causes for delays in chest tube removal following lung resection. While digital pleural drainage systems have been successfully used in the management of post-operative air leak, their effect on pleural drainage and inflammation has not been studied before. We hypothesized that digital drainage systems (as compared to traditional analog continuous suction), using intermittent balanced suction, are associated with decreased pleural inflammation and postoperative drainage volumes, thus leading to earlier chest tube removal...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28739772/efficacy-and-safety-of-nab-paclitaxel-as-second-line-chemotherapy-for-locally-advanced-and-metastatic-non-small-cell-lung-cancer
#10
Wenjing Wong, Ping Sun, Zhengbin Mu, Jiannan Liu, Caiyan Yu, Aina Liu
AIM: To investigate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) for locally advanced or metastatic non-small cell lung cancer (NSCLC) as second-line chemotherapy. PATIENTS AND METHODS: We retrospectively reviewed the treatment of 34 patients with advanced NSCLC whose first-line treatment had failed. These patients received nab-paclitaxel 260 mg/m(2) on day 1 and day 8 of a 21-day cycle from July 2014 to February 2016. One cycle of treatment lasted 3 weeks and all patients completed more than two cycles...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739703/cerebrospinal-fluid-penetration-rate-and-efficacy-of-afatinib-in-patients-with-egfr-mutation-positive-non-small-cell-lung-cancer-with-leptomeningeal-carcinomatosis-a-multicenter-prospective-study
#11
Akihiro Tamiya, Motohiro Tamiya, Takashi Nishihara, Takayuki Shiroyama, Keiko Nakao, Taisuke Tsuji, Naoko Takeuchi, Shun-Ichi Isa, Naoki Omachi, Norio Okamoto, Hidekazu Suzuki, Kyoichi Okishio, Ayano Iwazaki, Kimie Imai, Tomonori Hirashima, Shinji Atagi
BACKGROUND: Afatinib is an effective first-line treatment for epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC). However, few reports have addressed the influence of cerebrospinal fluid (CSF) penetration rate on the efficacy of afatinib in patients with central nervous system metastases. Therefore, we conducted a prospective multicenter trial to evaluate the CSF penetration rate and efficacy of afatinib in patients with EGFR mutation-positive NSCLC with leptomeningeal carcinomatosis...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739159/lung-stereotactic-body-radiation-therapy-sbrt-for-early-stage-non-small-cell-lung-cancer-in-the-very-elderly-%C3%A2-80years-old-extremely-safe-and-effective
#12
Paul Kreinbrink, Philip Blumenfeld, George Tolekidis, Neilayan Sen, David Sher, Gaurav Marwaha
OBJECTIVE: Stereotactic body radiotherapy (SBRT) for early-stage non-small-cell lung cancer (NSCLC) is the standard of care in medically inoperable patients. In very elderly patients, previous studies have shown SBRT to offer excellent local control, though with higher toxicities than in younger populations. We report our institutional experience using SBRT in the definitive management of NSCLC in patients ≥80years old. MATERIALS AND METHODS: Using an IRB-approved registry of 158 patients treated with definitive-intent lung SBRT for early-stage NSCLC at our institution between 2010 and 2016, 31 consecutively treated patients ≥80years of age were identified...
July 21, 2017: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/28738386/exercise-capacity-impairment-can-predict-postoperative-pulmonary-complications-after-liver-transplantation
#13
Clarissa Bentes de Araújo Magalhães, Ingrid Correia Nogueira, Liegina Silveira Marinho, Elizabeth F Daher, José Huygens P Garcia, Cyntia F G Viana, Pedro Felipe Carvalhedo de Bruin, Eanes Delgado Barros Pereira
BACKGROUND: Postoperative respiratory complications (PRCs) are common after liver transplantation (LT) and contribute significantly to the related morbidity and mortality. OBJECTIVE: The aim of this paper was to determine the incidence of PRCs after LT and the value of simple exercise capacity measures as independent predictors of PRCs. METHODS: We conducted a prospective cohort study of consecutive adults submitted to LT at a University Hospital in Fortaleza Brazil from March 2013 to March 2015...
July 22, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28737058/external-validity-of-electronic-sniffers-for-automated-recognition-of-acute-respiratory-distress-syndrome
#14
Andrew C McKown, Ryan M Brown, Lorraine B Ware, Jonathan P Wanderer
INTRODUCTION: Automated electronic sniffers may be useful for early detection of acute respiratory distress syndrome (ARDS) for institution of treatment or clinical trial screening. METHODS: In a prospective cohort of 2929 critically ill patients, we retrospectively applied published sniffer algorithms for automated detection of acute lung injury to assess their utility in diagnosis of ARDS in the first 4 ICU days. Radiographic full-text reports were searched for "edema" OR ("bilateral" AND "infiltrate") and a more detailed algorithm for descriptions consistent with ARDS...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28736513/low-cigarette-smoking-prevalence-in-peri-urban-peru-results-from-a-population-based-study-of-tobacco-use-by-self-report-and-urine-cotinine
#15
Brooks W Morgan, Kathryn M Leifheit, Karina M Romero, Robert H Gilman, Antonio Bernabe-Ortiz, J Jaime Miranda, Harold I Feldman, John J Lima, William Checkley
BACKGROUND: A recent study found lower self-reported prevalence of tobacco smoking in a peri-urban area of Lima, Peru than previously reported in urban samples. These regions encompass substantial proportions of Peru's population - ones at greater risk of disease due to reduced healthcare access - but have been less often studied. We validate low smoking prevalence with urine cotinine and characterize chronic disease and lung function outcomes between non-, occasional, and daily smokers...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28735769/the-elderly-are-less-likely-to-receive-recommended-radical-radiotherapy-for-non-small-cell-lung-cancer
#16
J McAleese, S Baluch, K Drinkwater, P Bassett, G G Hanna
AIMS: The National Institute for Healthcare Excellence recommends continuous hyperfractionated, accelerated radiotherapy (CHART), concurrent chemoradiation (cCRT) and stereotactic ablative radiotherapy (SABR) for appropriate patients with non-small cell lung cancer (NSCLC), but these are not universally available in all UK radiotherapy centres. Reduced access to these treatments may be contributing to reduced survival, with the concern that elderly patients are less likely to receive guideline-recommended therapy (GRT)...
July 20, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28735754/correlation-between-pulmonary-artery-pressure-and-thoracic-impedance-insights-from-daily-monitoring-through-an-implanted-device-in-chronic-heart-failure
#17
Giovanni Battista Perego, Matteo Oldani, Dario Pellegrini, Francesco Maria Angelo Brasca, Gabriella Malfatto, Alessandra Villani, Roberto Brambilla, Valeria Rella, Gianfranco Parati
BACKGROUND: Thoracic impedance (TI) decrease and pulmonary artery pressure (PAP) elevation precede acute decompensation in congestive heart failure (HF). However, the relationship between TI and PAP has been studied only in the context of acute decompensation. METHODS: This prospective, observational study enrolled subjects with reduced ejection fraction HF, previously implanted with an ICD capable of measuring TI. Patients underwent implantation of a sensor for direct measurement of PAP (CardioMEMs™)...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28734862/respiratory-infections-and-antibiotic-usage-in-common-variable-immunodeficiency
#18
Johannes M Sperlich, Bodo Grimbacher, Sarita Workman, Tanzina Haque, Suranjith L Seneviratne, Siobhan O Burns, Veronika Reiser, Werner Vach, John R Hurst, David M Lowe
BACKGROUND: Patients with common variable immunodeficiency (CVID) suffer frequent respiratory tract infections despite immunoglobulin replacement and are prescribed significant quantities of antibiotics. The clinical and microbiological nature of these exacerbations, the symptomatic triggers to take antibiotics, and the response to treatment have not been previously investigated. OBJECTIVES: To describe the nature, frequency, treatment, and clinical course of respiratory tract exacerbations in patients with CVID and to describe pathogens isolated during respiratory tract exacerbations...
July 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28734644/postmastectomy-radiation-therapy-technique-and-cardiopulmonary-sparing-a-dosimetric-comparative-analysis-between-photons-and-protons-with-free-breathing-versus-deep-inspiration-breath-hold
#19
Sagar A Patel, Hsiao-Ming Lu, Jacqueline A Nyamwanda, Rachel B Jimenez, Alphonse G Taghian, Shannon M MacDonald, Nicolas Depauw
PURPOSE: Dosimetric studies have suggested greater cardiopulmonary sparing with protons over photons for left-sided postmastectomy radiation therapy (PMRT). Modern techniques such as deep inspiration breath hold (DIBH) can help spare the heart. This analysis compares photon and proton delivery with and without DIBH. METHODS AND MATERIALS: Ten women with left breast cancer referred for PMRT on a prospective clinical trial with unfavorable cardiac anatomy underwent free breathing (FB) and DIBH computed tomography simulation...
June 21, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28734552/prevalence-and-predictive-value-of-pre-therapeutic-sarcopenia-in-cancer-patients-a-systematic-review
#20
REVIEW
Frédéric Pamoukdjian, Thierry Bouillet, Vincent Lévy, Michael Soussan, Laurent Zelek, Elena Paillaud
BACKGROUND & AIMS: To assess the prevalence of sarcopenia before cancer treatment and its predictive value during the treatment. METHODS: We searched MEDLINE via PubMed for articles published from 2008 to 2016 that reported prospective observational or interventional studies of the prevalence of pre-therapeutic sarcopenia and its consequences in adults with cancer who were 18 years or older. Two independent reviewers selected articles based on titles and/or abstracts before a complete review...
July 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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