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https://www.readbyqxmd.com/read/28090456/chronic-endometritis-and-infertility
#1
REVIEW
Hyun Jong Park, You Shin Kim, Tae Ki Yoon, Woo Sik Lee
Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28067420/cost-effectiveness-of-cytogenetic-evaluation-of-products-of-conception-by-chorionic-villous-sampling-in-recurrent-miscarriage
#2
Florencia Petracchi, Cecilia Paez, Laura Igarzabal
OBJECTIVE: To compare the cost-effectiveness of performing chorionic villous sampling (CVS) of products of conception (POC) in the evaluation of recurrent miscarriage versus standard evidence based work-up (EBW) of the couple. MATERIAL AND METHODS: A Decision-analytic model was performed in couples with a third miscarriage. Three strategies were considered: 1)the standard EBW of all the patients: comprising parental karyotype, uterine cavity assessment and antiphospholipid antibodies...
January 9, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28065221/meta-analysis-of-aspirin-heparin-therapy-for-un-explained-recurrent-miscarriage
#3
Tong Ling, Wei Xian-Jiang
Objective This study was designed to evaluate the efficacy and safety of aspirin-heparin treatment for un-explained recurrent spontaneous abortion (URSA). Methods Literatures reporting the studies on the aspirin-heparin treatment of un-explained recurrent miscarriage with randomized controlled trials (RCTs) were collected from the major publication databases. The live birth rate was used as primary indicator, preterm delivery, preeclampsia, intrauterine growth restriction, and adverse reactions (thrombocytopenia ) were used as the secondary indicators...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28063029/tracheo-esophageal-fistula-tef-in-a-newborn-following-maternal-antenatal-exposure-to-olanzapine
#4
Vikas Maharshi, Indranil Banerjee, Pravesh Nagar, Harmeet Singh Rehan
There is a dearth of evidence on the safety of the use of antipsychotics during pregnancy. Olanzapine, a pregnancy category C drug, has no unequivocal evidence of harm to the fetus. Against this backdrop, we report the first case of a tracheo-esophageal fistula (TEF) in a newborn following maternal antenatal exposure to olanzapine. A 29-year-old woman with acute psychotic disorder had been treated with olanzapine for the last 7 years. Her first pregnancy, while taking olanzapine, resulted in a miscarriage at 4 months' gestation, following which she discontinued olanzapine...
December 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/28050964/risks-of-myrrh-usage-in-pregnancy
#5
Dania Al-Jaroudi, Ouhoud Kaddour, Nahla Al-Amin
Recurrent miscarriage places a huge psychological burden on a woman who is trying to conceive. Meanwhile, the use of traditional medicine still plays an important role within the Saudi Arabian culture, where many patients still seek alternative forms of therapy. However, this traditional way of treatment might expose patients to many hazards. We present a case of a 32-year-old pregnant woman with a history of infertility and recurrent miscarriages. She used large amounts of myrrh herbs for 2 months, since a traditional healer told her that her current pregnancy would progress safely by its use...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28041830/luteal-phase-hcg-support-for-unexplained-recurrent-pregnancy-loss-a-low-hanging-fruit
#6
Chelsea Fox, Denise Azores-Gococo, Linda Swart, Kristin Holoch, Ricardo F Savaris, Creighton E Likes, Paul B Miller, David A Forstein, Bruce A Lessey
Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies and accounts for only 1-5% of pregnancy failures. Treatment options for unexplained RPL (uRPL) are limited. Previous studies suggest a link between delayed implantation and pregnancy loss. Based on this, a timely signal for rescue of the corpus luteum (CL) using human chorionic gonadotrophin (HCG) could improve outcomes in women with uRPL. This retrospective cohort study included 98 subjects with uRPL: 45 underwent 135 monitored cycles without HCG support; and 53 underwent 142 cycles with a single mid-luteal HCG injection...
December 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28029224/preterm-prelabour-rupture-of-membranes-a-retrospective-cohort-study-of-association-with-adverse-outcome-in-subsequent-pregnancy
#7
I M Aris, S Logan, C Lim, M Choolani, A Biswas, S Bhattacharya
OBJECTIVE: To assess the association of first pregnancy preterm prelabour rupture of membranes (PPROM) with adverse maternal and perinatal outcomes in the next pregnancy. DESIGN: Retrospective cohort study. SETTING: Grampian, Scotland, UK. POPULATION: Women with first deliveries recorded in the Aberdeen Maternity Neonatal Databank, 1986-2005. METHODS: Women identified from the AMND database (n = 37 776) were classified into exposed (PPROM in first pregnancy; n = 1979) and unexposed (no PPROM in first pregnancy; n = 35 797) cohorts...
December 28, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28024303/depression-in-women-with-recurrent-miscarriages-an-exploratory-study
#8
Ariel Cesar de Carvalho, Michele Eugênio da Silva, Bárbara Magueta Matos, Cassio Machado de Campos Bottino, Anelise Riedel Abrahão, Frederico Molina Cohrs, Sara Mota Borges Bottino
Objective To assess depression, domestic violence and the use of substances in women with recurrent miscarriages. Methods The Abuse Assessment Screen (AAS), the Edinburgh Postnatal Depression Scale (EPDS) and the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) were used to assess violence, depression and the use of substances among women with recurrent miscarriages. The population corresponded to patients receiving prenatal care from June to August 2014. Multiple logistic regression was used to assess the multivariable relationship between depression and sociodemographic, psychosocial and medical characteristics (p < 0,10)...
December 26, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28007693/pad4-deficiency-decreases-inflammation-and-susceptibility-to-pregnancy-loss-in-a-mouse-model
#9
Luise Erpenbeck, Chanchal Sur Chowdhury, Zsuzsanna K Zsengellér, Maureen Gallant, Suzanne D Burke, Stephen Cifuni, Sinuhe Hahn, Denisa D Wagner, S Ananth Karumanchi
Inflammation is thought to play a critical role in the pathogenesis of placentation disorders such as recurrent miscarriages, growth restriction, and preeclampsia. Recently, neutrophil extracellular traps (NETs) have emerged as a potential mechanism for promoting inflammation in both infectious and noninfectious disorders. To investigate a pathogenic role for NETs in placentation disorders, we studied a model of antiangiogenic factor-mediated pregnancy loss in wild-type (WT) mice and in mice deficient in peptidylarginine deiminase 4 (Padi4(-/-)) that are unable to form NETs...
December 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/28004193/lymphocyte-immunotherapy-in-the-treatment-of-recurrent-miscarriage-systematic-review-and-meta-analysis
#10
Marcelo Borges Cavalcante, Manoel Sarno, Edward Araujo Júnior, Fabricio Da Silva Costa, Ricardo Barini
PURPOSE: Recurrent miscarriage (RM) affects up to 2-3% of couples of reproductive age. There are several causes for this condition, including immunologic. The embryo is considered an allograft, subject to the rejection mechanisms of the maternal immune system. Immunotherapy involving immunization with lymphocytes is considered in cases of idiopathic RM. However, there is still no consensus regarding the efficacy and safety of this therapy. METHODS: This systematic review and meta-analysis evaluated the data available in the literature regarding the efficacy and safety of the use of immunotherapy with lymphocytes in couples with history of RM...
December 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27994187/cytogenetic-analysis-in-couples-with-recurrent-miscarriages-a-retrospective-study-from-punjab-north-india
#11
Neha Sudhir, Tajinder Kaur, Archana Beri, Anupam Kaur
Human reproduction is considered as the most inefficient event as ~15-20% of human pregnancies end in miscarriage and in the product of miscarriages, chromosomal anomalies are a common occurrence. The aim of the present retrospective study was to assess the frequency of chromosomal aberrations in couples with recurrent miscarriages in the region of Punjab and to compare with worldwide frequencies. In this study, a total of 440 cases were referred between the period 1995-2015. After lymphocyte culturing, giemsa-trypsin banding was done for each case to assess the chromosomal anomalies...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27979878/implications-of-telomeres-and-telomerase-in-endometrial-pathology
#12
REVIEW
D K Hapangama, A Kamal, G Saretzki
BACKGROUND: Eukaryotic chromosomal ends are linear and are protected by nucleoprotein complexes known as telomeres. The complex structural anatomy and the diverse functions of telomeres as well as the unique reverse transcriptase enzyme, telomerase that maintains telomeres are under intensive scientific scrutiny. Both are involved in many human diseases including cancer, but also in ageing and chronic disease such as diabetes. Their intricate involvement in many cellular processes and pathways is being dynamically deciphered in many organs including the endometrium...
December 15, 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27966754/translocation-breakpoints-of-chromosome-4-in-male-carriers-clinical-features-and-implications-for-genetic-counseling
#13
H G Zhang, R X Wang, Y Pan, J H Zhu, L T Xue, X Yang, R Z Liu
Cytogenetic analysis remains a powerful and cost-effective technology, and has wide applicability in genetic counseling for infertile males. Chromosomal rearrangements are thought to be one of the major genetic factors that influence male infertility. Some carriers with balanced reciprocal translocation have been identified as having oligozoospermia or azoospermia, and there is an association between balanced translocation and recurrent abortion. Researchers have reported the involvement of chromosome 4 translocations in male factor infertility and recurrent miscarriages...
December 2, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27958626/genetic-causes-of-recurrent-miscarriages
#14
Marta Kacprzak, Marta Chrzanowska, Beata Skoczylas, Hanna Moczulska, Maciej Borowiec, Piotr Sieroszewski
Recurrent miscarriage is an important problem in reproductive health, which affects 1-5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27957444/a-novel-mutation-in-the-ofd1-gene-in-a-family-with-oral-facial-digital-syndrome-type-1-a-case-report
#15
Masoud Dehghan Tezerjani, Reza Maroofian, Mohammad Yahya Vahidi Mehrjardi, Barry A Chioza, Shiva Zamaninejad, Seyed Mehdi Kalantar, Mahmoud Nori-Shadkam, Hamidreza Ghadimi, Emma L Baple, Andrew H Crosby, Mohammadreza Dehghani
Oral-facial-digital syndrome as heterogeneous developmental conditions is characterized by abnormalities in the oral cavity, facial features and digits. Furthermore, central nervous system (CNS) abnormalities can also be part of this developmental disorder. At least 13 forms of OFDS based on their pattern of signs and symptoms have been identified so far. Type 1 which is now considered to be a ciliopathy accounts for the majority of cases. It is transmitted in an X-linked dominant pattern and caused by mutations in OFD1 gene, which can result in embryonic male lethality...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27929073/rna-sequencing-of-chorionic-villi-from-recurrent-pregnancy-loss-patients-reveals-impaired-function-of-basic-nuclear-and-cellular-machinery
#16
Siim Sõber, Kristiina Rull, Mario Reiman, Piret Ilisson, Pirkko Mattila, Maris Laan
Recurrent pregnancy loss (RPL) concerns ~3% of couples aiming at childbirth. In the current study, transcriptomes and miRNomes of 1(st) trimester placental chorionic villi were analysed for 2 RPL cases (≥6 miscarriages) and normal, but electively terminated pregnancies (ETP; n = 8). Sequencing was performed on Illumina HiSeq 2000 platform. Differential expression analyses detected 51 (27%) transcripts with increased and 138 (73%) with decreased expression in RPL compared to ETP (DESeq: FDR P < 0...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895849/celiac-disease-and-obstetrical-gynecological-contribution
#17
REVIEW
Giovanni Casella, Guido Orfanotti, Loredana Giacomantonio, Camillo Di Bella, Valentina Crisafulli, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
Celiac disease (CD) shows an increased prevalence in female, particularly during the fertile period. Celiac disease should be researched in infertility, spontaneous and recurrent abortions, delayed menarche, amenorrhea, early menopause, and children with low birth-weight. Celiac disease is still little considered during the evaluation of infertility. Up to 50% of women with untreated CD refer an experience of miscarriage or an unfavorable outcome of pregnancy. Celiac patients taking a normal diet (with gluten) have a shorter reproductive period...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27893839/no-association-between-tnf-%C3%AE-308g-a-polymorphism-and-idiopathic-recurrent-miscarriage-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#18
Jiashu Dong, Jinwan Li, Gechen Zhou, Zheng Peng, Jingjing Li, Shengzhang Lin, Haihua Liu, Chunlin Wu, Yujie Huang, Xiaolan Lv, Shengming Dai
BACKGROUND: Conflicting results were reported on the association between the TNF-α -308G/A polymorphism and idiopathic recurrent miscarriage (IRM). Though three meta-analyses have been conducted on this topic, the conclusions were contradictory, and the results may be unreliable as certain crucial conditions were neglected. METHOD: A complete search was conducted in PubMed, Cochrane Library, and Embase, other sources like Google Scholar, ClinicalTrial.gov and reference lists of relevant articles were also retrieved...
2016: PloS One
https://www.readbyqxmd.com/read/27887715/focus-on-recurrent-miscarriage-phenotypes
#19
EDITORIAL
David H Barad, Vitaly A Kushnir, Norbert Gleicher
No abstract text is available yet for this article.
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27887710/supplementation-with-progestogens-in-the-first-trimester-of-pregnancy-to-prevent-miscarriage-in-women-with-unexplained-recurrent-miscarriage-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
Gabriele Saccone, Corina Schoen, Jason M Franasiak, Richard T Scott, Vincenzo Berghella
OBJECTIVE: To investigate whether treatment with progestogens in the first trimester of pregnancy would decrease the incidence of miscarriage in women with a history of unexplained recurrent miscarriage. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with a history of unexplained recurrent miscarriage. INTERVENTION(S): Randomized, controlled trials were identified by searching electronic databases...
November 22, 2016: Fertility and Sterility
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