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recurrent miscarriages

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https://www.readbyqxmd.com/read/29040571/patient-centered-early-pregnancy-care-a-systematic-review-of-quantitative-and-qualitative-studies-on-the-perspectives-of-women-and-their-partners
#1
M M J van den Berg, E A F Dancet, T Erlikh, F van der Veen, M Goddijn, P J Hajenius
BACKGROUND: Early pregnancy complications, defined as miscarriage, recurrent miscarriage or ectopic pregnancy, affect the physical and psychological well-being of intended parents. Research in this field so far has focused mainly on improving accuracy of diagnostic tests and safety and effectiveness of therapeutic management. An overview of aspects of care valued by women and/or their partners is missing. OBJECTIVE AND RATIONALE: This systematic review aims to provide an overview of aspects of care valued by women and/or their partners faced with early pregnancy complications and to identify potential targets for improvement in early pregnancy healthcare...
October 11, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29040297/decreased-nk-cell-immunity-in-kidney-transplant-recipients-late-post-transplant-and-increased-nk-cell-immunity-in-patients-with-recurrent-miscarriage
#2
Li Zhu, Mostafa Aly, Haihao Wang, Hristos Karakizlis, Rolf Weimer, Christian Morath, Ruben Jeremias Kuon, Bettina Toth, Gerhard Opelz, Volker Daniel
BACKGROUND: There is evidence that NK-cell reactivity might affect graft outcome in transplant recipients and pregnancy in women. METHOD: NK-cell subsets were determined in whole blood using eight-colour-fluorescence flow cytometry in patients before and after renal transplantation, patients with recurrent miscarriage (RM) and healthy controls (HC). RESULTS: Patients late post-transplant (late-Tx) with functioning renal transplants showed abnormally low CD56dimCD16+ NK-cells containing both perforin and granzyme (vs HC p = 0...
2017: PloS One
https://www.readbyqxmd.com/read/29030251/intravenous-immunoglobulin-ivig-treatment-modulates-peripheral-blood-th17-and-regulatory-t-cells-in-recurrent-miscarriage-patients-non-randomized-open-label-clinical-trial
#3
Majid Ahmadi, Sanaz Abbaspour Aghdam, Mohammad Nouri, Zohreh Babaloo, Laya Farzadi, Aliye Ghasemzadeh, Kobra Hamdi, Ali Akbar Movassaghpour, Farhad Jadidi-Niaragh, Amir Afkham, Morteza Motallebnezhad, Shadi Eghbal-Fard, Sanam Dolati, Vahid Younesi, Mehdi Yousefi
BACKGROUND: Th17 cells and Treg cells have been proposed as new risk factors for recurrent miscarriage (RM). In this study, we investigated the effect of Intravenous immunoglobulin G (IVIG) on the levels and function of Th17 and Treg cells and pregnancy outcome in women with RM. MATERIALS AND METHODS: 94 pregnant women with RM were enrolled in this study. Blood was drawn at the time of positive pregnancy. On the same day, IVIG 400mg/kg was administered intravenously for 44 patients...
October 10, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29020784/-screening-of-endometrial-nk-cells-in-selected-infertile-patients-first-part-methods-and-current-results
#4
Z Ulčová-Gallová, M Pešek, P Chaloupka, P Mukešnábl, M Haschová, P Losan, K Bibková, Z Mičanová, J Cibulka
INTRODUCTION: Generaly, natural killer cells (NK cells) are among the most important cells of our immune defense system. They are present in the blood, decidua but also in secretory endometrium. OBJECTIVE: We investigate an association between high density of NK cells CD56+ and NK cells CD16+ into blood and secretory endometrium in patients with up to now unexplained recurrent miscarriage. At the same time, we focused on diagnosis of antiphospholipid syndrome, congenital trombophilic factors, stress factor, and lenght of hormonal contraception before conception...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29017513/association-between-tnf-il1b-il6-il10-and-ifng-polymorphisms-and-recurrent-miscarriage-a-case-control-study
#5
Jianting Ma, Xingguang Zhang, Gang He, Chunlin Yang
BACKGROUND: Approximately half of recurrent miscarriages have unexplained etiology. Recent evidences suggest that cytokines are important determinants in pregnancy maintenance and as such, cytokine gene polymorphisms, which can affect cytokine production and/or functionality, could play a role in the disorder. Thus, we aimed to investigate the association of selected cytokine gene polymorphisms with risk of recurrent miscarriage among Chinese. METHODS: TNF -238G > A, TNF -308G > A, IL1B -511 T > C, IL1B 3954C > T, IL6 -174G > C, IL6 -634C > G, IL10 -1082A > G and IFNG 874A > T polymorphisms were genotyped on 775 women with idiopathic recurrent miscarriage and 805 healthy parous control women...
October 10, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29016496/leiomyomas-in-pregnancy-and-spontaneous-abortion-a-systematic-review-and-meta-analysis
#6
Alexandra C Sundermann, Digna R Velez Edwards, Michael J Bray, Sarah H Jones, Sanura M Latham, Katherine E Hartmann
OBJECTIVE: To systematically review studies reporting the risk of spontaneous abortion among pregnant women of typical reproductive potential with and without uterine leiomyomas. DATA SOURCES: We searched PubMed, EMBASE, Web of Science, and ClinicalTrials.gov for publications from January 1970 to December 2016. METHODS OF STUDY SELECTION: We excluded studies that did not use imaging to uniformly document leiomyoma status of all participants, did not have a comparison group without leiomyomas, or primarily included women seeking care for recurrent miscarriage, infertility care, or assisted reproductive technologies...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28993281/two-miscarriages-consecutive-or-non-consecutive-does-it-change-something
#7
Chloe Cardinale, Julie Berbis, Cecile Chau, Fanny Bernard, Dominique Arnoux, Marie Francoise Fratacci, Leon Boubli, Florence Bretelle
OBJECTIVES: To assess the rate of anomalies in the etiological evaluation of patients presenting recurrent early miscarriages (RM) according to miscarriage chronology (number of miscarriages, history of live birth and succession of RM). METHODS: Retrospective single centre study including RM, defined as at least 2 miscarriages at less than 14 weeks of gestation (WG) between the 1(st) January 2012 and the 31(st) December 2015. Clinical data and etiological evaluation include blood glucose levels, screening for antiphospholipid syndrome (APS), endocrine assessment, vitamin levels, pelvic imaging, karyotyping of both partners, chronic endometritis and thrombophilia screening...
October 6, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28988928/preimplantation-genetic-screening-results-of-a-worldwide-web-based-survey
#8
Ariel Weissman, Gon Shoham, Zeev Shoham, Simon Fishel, Milton Leong, Yuval Yaron
Our objective was to evaluate and characterize the extent and patterns of worldwide usage of preimplantation genetic screening (PGS) among the assisted reproductive technique community. A prospective, web-based questionnaire with questions relating to practices of, and views on, PGS was directed to users and non-users of PGS. A total of 386 IVF units from 70 countries conducting 342,600 IVF cycles annually responded to the survey. A total of 77% of respondents routinely carry out PGS in their clinics for a variety of indications: advanced maternal age (27%), recurrent implantation failure (32%) and recurrent pregnancy loss (31%)...
September 21, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28985591/antiphospholipid-syndrome-and-recurrent-miscarriage-a-systematic-review-and-meta-analysis
#9
REVIEW
Thaís da Silva Santos, Andressa Lorena Ieque, Hayalla Corrêa de Carvalho, Ana Maria Sell, Maria Valdrinez Campana Lonardoni, Izabel Galhardo Demarchi, Quirino Alves de Lima Neto, Jorge Juarez Vieira Teixeira
Antiphospholipid syndrome (APS) is an autoimmune condition that is associated with thrombosis and morbidity in pregnancy. The exact mechanisms by which these associations occur appear to be heterogeneous and are not yet well understood. The aim of this study was to identify and analyze publications in recent years to better understand the diagnosis and its contribution to monitoring APS among women with recurrent miscarriage (RM). This systematic review and meta-analysis was conducted using the PubMed and Web of Knowledge databases, with articles published between 2010 and 2014, according to the PRISMA statement...
September 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28980840/prolactin-receptor-gene-polymorphism-and-the-risk-of-recurrent-pregnancy-loss-a-case-control-study
#10
Jin Ju Kim, Young Min Choi, Sung Ki Lee, Kwang Moon Yang, Eun Chan Paik, Hyeon Jeong Jeong, Jong Kwan Jun, Ae Ra Han, Kyu Ri Hwang, Min A Hong
Since the first study was published reporting the candidate association between the prolactin receptor gene intron C/T polymorphism (rs37389) and recurrent miscarriage, no replication study has been performed. In this study, we investigated the role of the prolactin receptor gene C/T polymorphism in 311 Korean women with recurrent pregnancy loss and 314 controls. Genotyping for prolactin receptor gene intron C/T polymorphism was performed using a TaqMan assay. The significance of difference in the genotype distribution was assessed using a chi-square test, and continuous variables were compared using a Student's t-test...
October 5, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28972310/genetic-variation-in-the-progesterone-receptor-gene-and-susceptibility-to-recurrent-pregnancy-loss-a-case-control-study
#11
Wael Bahia, Ramzi R Finan, Mariam Al-Mutawa, Anis Haddad, Aymen Soua, Faouzi Janhani, Touhami Mahjoub, Wassim Y Almawi
OBJECTIVE: To investigate the association of progesterone receptor (PGR) gene variants with the susceptibility to recurrent pregnancy loss (RPL). DESIGN: Retrospective case-control study. SETTING: Outpatient obstetrics/gynecology clinics. POPULATION: Women with RPL (396), defined as ≥3 consecutive miscarriages of unknown etiology, and 361 control women. METHODS: PGR genotyping was done by allelic exclusion method (real-time PCR)...
October 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28951537/tim-3-signaling-in-peripheral-nk-cells-promotes-maternal-fetal-immune-tolerance-and-alleviates-pregnancy-loss
#12
Yanhong Li, Jiayuan Zhang, Di Zhang, Xiaowu Hong, Yu Tao, Songcun Wang, Yuanyuan Xu, Hailan Piao, Weijie Yin, Min Yu, Yin Zhang, Qiang Fu, Dajin Li, Xing Chang, Meirong Du
Pregnancy loss occurs in about 15% of clinically recognized pregnancies, and defective maternal-fetal immune tolerance contributes to more than 50% of these events. We found that signaling by the type I membrane protein T cell immunoglobulin and mucin-containing protein 3 (Tim-3) in natural killer (NK) cells had an essential protective role during early pregnancy. Tim-3 on peripheral NK (pNK) cells was transiently increased in abundance during the first trimester of pregnancy, which depended on interleukin-4 (IL-4)-signal transducer and activator of transcription 6 (STAT6) and progesterone signaling...
September 26, 2017: Science Signaling
https://www.readbyqxmd.com/read/28935491/measurement-of-uterine-natural-killer-cell-percentage-in-the%C3%A2-periimplantation-endometrium-from-fertile-women-and-women-with-recurrent-reproductive-failure-establishment-of-a-reference-range
#13
Xiaoyan Chen, Najat Mariee, Lingming Jiang, Yingyu Liu, Chi Chiu Wang, Tin Chiu Li, Susan Laird
BACKGROUND: Uterine natural killer cells are the major leukocytes present in the periimplantation endometrium. Previous studies have found controversial differences in uterine natural killer cell percentage in women with recurrent reproductive failure compared with fertile controls. OBJECTIVE: We sought to compare the uterine natural killer cell percentage in women with recurrent reproductive failure and fertile controls. STUDY DESIGN: This was a retrospective study carried out in university hospitals...
September 19, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28928434/the-effect-of-frozen-thawed-embryo-transfer-performed-concurrently-with-hysteroscopy-on-the-reproductive-outcomes-during-assisted-reproductive-treatments
#14
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
The uterine environment is vital to the successful conception; recently, hysteroscopy was used to remove uterine anomalies in patients undergoing assisted reproductive treatments in combination with a "freeze-all" strategy. However, the rapid recurrence of uterine anomalies impose a negative impact on pregnancy. A possible way to avoid this issue is to implement frozen-thawed embryo transfer (FET) as soon as possible. Thus, we sought to investigate the impact of performing FET concurrently with hysteroscopy in the same mense on the pregnancy outcome...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924537/inherited-thrombophilias-could-influence-the-reproductive-outcome-in-women-with-systemic-lupus-erythematosus
#15
R Robeva, D Tanev, S Andonova, M Nikolova, A Tomova, Ph Kumanov, A Savov, R Rashkov, Zl Kolarov
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with different reproductive complications in the affected women. Inherited thrombophilias are genetic factors increasing the risk for thromboembolism and recurrent pregnancy loss, but their influence on other reproductive disturbances in SLE patients has not been completely clarified. Two hundred and twenty-three Caucasian women (112 with SLE and 111 controls) were included in the study. Complete reproductive history of all SLE patients was carefully obtained...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28923404/hla-g-coding-region-polymorphism-is-skewed-in-autistic-spectrum-disorders
#16
Franca R Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Enrico Ripamonti, Alessandro Ghezzo, Michela Zanette, Stefano Sotgiu, Maria Martina Mensi, Alessandra Carta, Maria Paola Canevini, Milena Zanzottera, Cristina Agliardi, Andrea S Costa, Umberto Balottin, Mario Clerici
Different isoforms of HLA-G protein are endowed with a differential ability to induce allogenic tolerance during pregnancy. As prenatal immune activation is suggested to play a role in the onset of autistic spectrum disorders (ASD), we evaluated HLA G*01:01-*01:06 allelic polymorphism in a cohort of Italian children affected by ASD (N=111) their mothers (N=81), and their healthy siblings (N=39). DNA sequencing analysis of HLA-G exon 2, 3 and 4 was used to obtain HLA-G allelic frequencies; alleles distribution was compared with that of two control groups of Caucasoid couples of multiparous women and their partners from Brazil and Denmark...
September 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28900713/complement-activation-a-threat-to-pregnancy
#17
REVIEW
Guillermina Girardi
Pregnancy poses a challenge for the immune systems of placental mammals. As fetal tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the fetus and the placenta might be subject to complement-mediated immune attack with the potential risk of adverse pregnancy outcomes. Here, I describe how the use of animal models was pivotal in demonstrating that complement inhibition at the fetomaternal interface is essential for a successful pregnancy. Studies in animals also helped the identification of uncontrolled complement activation as a crucial effector in the pathogenesis of recurrent miscarriages, intrauterine growth restriction, preeclampsia, and preterm birth...
September 12, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28867860/ayurvedic-management-of-recurrent-abortions-due-to-uterine-fibroid
#18
Shailendra Dadarao Katakdound
Uterine fibroids are present in 30-70% of women of reproductive age. Uterine fibroids distort the uterine cavity. Therefore there is consensus of a negative impact on both the clinical pregnancy and delivery rates.[2] In addition, studies have also reported an increased risk of spontaneous miscarriage with submucosal fibroids. In biomedicine, myomectomy is considered the treatment of choice and Assisted Reproductive Technology is advised to overcome infertility. In Hārita Saṃhitā treatment is given for recurrent abortion (Garbhasrāvī)...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28865602/placental-apoptosis-in-recurrent-miscarriage
#19
Tarek A Atia
Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53) protein was significantly increased in the placental tissues of the RM group (p = 0...
September 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28863939/semen-quality-and-pregnancy-loss-in-a-contemporary-cohort-of-couples-recruited-before-conception-data-from-the-longitudinal-investigation-of-fertility-and-the-environment-life-study
#20
Michael L Eisenberg, Katherine J Sapra, Sung Duk Kim, Zhen Chen, Germaine M Buck Louis
OBJECTIVE: To study the relationship between semen quality and pregnancy loss in a cohort of couples attempting to conceive. DESIGN: Observational prospective cohort. SETTING: Not applicable. PATIENT(S): Three hundred and forty-four couples with a singleton pregnancy observed daily through 7 postconception weeks of gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Association between semen quality and pregnancy loss...
October 2017: Fertility and Sterility
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