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recurrent miscarriages

Levent Dikbas, Riza Dur, İsmail Hakkı Tas, Ömer Erkan Yapça, Neslihan Dikbas
OBJECTIVE: Oxidative stress has been reported to be associated with various pregnancy complications and to play key roles in many of them. An inadequate level of antioxidant defense may eventually lead to an early pregnancy loss. There is a lack of information about the roles of the PON2 and PON3 enzymes in the etiology of the cases of unexplained recurrent abortus. The aim of our study is to determine and present the data regarding the roles of these enzymes for the first time. MATERIALS AND METHODS: We measured the transcriptional levels of the PON2 and PON3 enzymes in the curettage materials obtained from the patients with unexplained recurrent abortus (n=25) and compared the results with those measured in the abortus materials from healthy pregnant women (n=50) who had undergone a voluntary abortion...
June 14, 2018: Journal of Gynecology Obstetrics and Human Reproduction
Amerigo Vitagliano, Carlo Saccardi, Marco Noventa, Attilio Di Spiezio Sardo, Gabriele Saccone, Ettore Cicinelli, Sara Pizzi, Alessandra Andrisani, Pietro Salvatore Litta
OBJECTIVE: To evaluate the impact of antibiotic therapy for chronic endometritis (CE) on IVF outcome. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Infertile women with history of recurrent implantation failure, defined as two or more failed ETs, undergoing one or more IVF cycle(s). INTERVENTION(S): The review was registered in PROSPERO (CRD42017062494) before the start of the literature search...
June 13, 2018: Fertility and Sterility
Takumi Sano, Yoshito Terai, Atsushi Daimon, Misa Nunode, Yoko Nagayasu, Atsuko Okamoto, Daisuke Fujita, Masami Hayashi, Masahide Ohmichi
INTRODUCTION: Placental insufficiency is one of the major risk factors for growth restriction and preeclampsia. The aim of this study is to investigate whether recombinant human Thrombomodulin(r-TM) improves fetal conditions and physiological outcomes. METHODS: We used CBA/J × BALB/C mice as a control and CBA/J × DBA/2 mice - a well-studied model of recurrent spontaneous miscarriage. Pregnant mice received daily subcutaneous injections of r-TM or saline from day 0-15...
May 2018: Placenta
Fionnuala Mone, Fionnuala M McAuliffe, Sally Ann Lynch
Irish Travellers are an endogamous nomadic ethnic minority population mostly resident on the island of Ireland with smaller populations living in Europe & USA. As they practice consanguinity, rare and ultra-rare autosomal recessive conditions are observed which are infrequently seen in the general population. Awareness of the rare genetic disorders within an antenatal setting that recur within this population should facilitate quicker cost-effective diagnosis. These include disorders leading to recurrent miscarriage and multiple congenital anomalies...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Panagiotis Tsikouras, Anna Christoforidou, Anastasia Bothou, Dorelia Deuteraiou, Xanthoula Anthoulaki, Anna Chalkidou, Stefanos Zervoudis, Georgios Galazios
BACKGROUND: The risk of thromboembolic events during pregnancy in patients with antithrombin deficiency is increased. Preventing thromboembolic events during pregnancy in the case of antithrombin deficiency is still a matter of concern. CASE PRESENTATION: We present a case of a 19-year-old primigravida Greek Pomak woman, who was diagnosed as having congenital antithrombin deficiency. She had a history of recurrent miscarriages and a family history of thrombosis...
June 16, 2018: Journal of Medical Case Reports
Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng
PROBLEM: The role of ILT4+ DCs in healthy fertile controls and patients with recurrent miscarriages (RM) and recurrent implantation failure (RIF) is unclear. METHOD OF STUDY: We studied the expression of ILT4 from peripheral blood and endometrial samples from healthy controls and patients with RM and RIF by flow cytometry and immunohistochemistry analysis. Endometrial Foxp3 expression was also investigated using immunohistochemistry. RESULTS: In peripheral blood, there was a significant increase in the percentage of ILT4+ DCs in healthy fertile controls compared with patients with RM and RIF...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
Pier Luigi Meroni, Maria Orietta Borghi, Claudia Grossi, Cecilia Beatrice Chighizola, Paolo Durigutto, Francesco Tedesco
Recurrent thrombosis and miscarriages are the main clinical manifestations of antiphospholipid syndrome (APS). Although most patients display both clinical signs, some patients can have isolated vascular or obstetric variants. Emerging data raise the question of whether obstetric and vascular APS are the same or different diseases. An important difference between the two conditions is that a thrombophilic state is a common feature in vascular APS, whereas clot occlusions of the decidual spiral arteries are seldom observed in obstetric APS, and infarctions are found in only one-third of APS placentae...
June 11, 2018: Nature Reviews. Rheumatology
Catherine McCormack, Shalem Leemaqz, Denise Furness, Gustaaf Dekker, Claire Roberts
AIMS: Some studies have suggested that vitamin D deficiency is associated with an increased risk of first trimester miscarriages, others have suggested that it is associated with an increased risk of hyperinsulinism/insulin resistance and the development of gestational diabetes. Hyperinsulinism is also thought to increase miscarriages. We investigated the association between vitamin D levels and hyperinsulinism in a cohort of recurrent miscarriage patients. METHODS: Patients undergoing miscarriage investigations had insulin and vitamin D levels tested...
June 8, 2018: Journal of Maternal-fetal & Neonatal Medicine
J Ricci Hagman, A K Hult, J S Westman, B Hosseini-Maaf, P Jongruamklang, J Saipin, S Bejrachandra, M L Olsson
OBJECTIVES: To determine the genetic background underlying the Pk phenotype in two Thai sisters suffering from multiple spontaneous abortions. BACKGROUND: The P antigen is carried by globoside, an abundant glycosphingolipid in the red blood cell (RBC) membrane. Inactivating mutations in the 3-β-N-acetylgalactosaminyltransferase gene (B3GALNT1) give rise to the rare Pk phenotype, which lack the P and PX2 antigens. Consequently, naturally occurring anti-P may cause recurrent miscarriages following the cytotoxic attack of the globoside-rich fetal portion of the placenta...
June 6, 2018: Transfusion Medicine
Tanzil Ur Rahman, Kamran Ullah, Meng-Xi Guo, Hai-Tao Pan, Juan Liu, Jun Ren, Lu-Yang Jin, Yu-Zhong Zhou, Yi Cheng, Jian-Zhong Sheng, He-Feng Huang
High androgen level impairs endometrial receptivity in women experiences the recurrent miscarriage. The mechanism of androgen actions on endometrium is still uncertain. We hypothesized that androgen has a direct effect on the endometrium in women with recurrent miscarriage. In the present study, we assess the impact of androgen (A2 ) at high concentration (10-7 M) on Ishikawa cells compared with the physiological concentration of androgen (10-9 M). To go into deeper analysis, we use global stable isotopes labeled profiling tactic using iTRAQ reagents, followed by 2D LC-MS/MS...
May 15, 2018: Oncotarget
Brianna M Lyttle Schumacher, Anne Marie Z Jukic, Anne Z Steiner
OBJECTIVE: To determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies. DESIGN: Prospective cohort study. SETTING: Not applicable. PATIENT(S): Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally. INTERVENTION(S): None...
June 2, 2018: Fertility and Sterility
Deepa R J Arachchillage, Mike Makris
Recurrent miscarriages and pregnancy-related complications cause significant stress to couples looking for successful pregnancy outcome as well as to health care professionals. There is conflicting evidence with respect to the presence and the strength of associations between inherited thrombophilia and these complications. A complete thrombophilia screen is expensive, and no proven effective treatment for women with recurrent miscarriage and inherited thrombophilia is currently available. Based on the concept of microvascular thrombosis of the placenta, women with recurrent miscarriage and placenta-related complications frequently get treated with antithrombotic therapy...
June 4, 2018: Seminars in Thrombosis and Hemostasis
J L Saes, S E M Schols, W L van Heerde, M R Nijziel
Hyperfibrinolytic bleeding can be caused by a deficiency of one of the inhibitors of fibrinolysis (plasminogen activator inhibitor type 1 (PAI-1) or α2-antiplasmin (α2-AP), or an excess of one of the activators of fibrinolysis: tissue type plasminogen activator or urokinase type plasminogen activator. This review focuses on the clinical implications of these disorders. The bleeding phenotype of fibrinolytic disorders is characterized by delayed bleeding after trauma, surgery and dental procedures. Bleeding in areas of high fibrinolytic activity is also common, such as menorrhagia and epistaxis...
May 30, 2018: Journal of Thrombosis and Haemostasis: JTH
Altug Koc, Ozgur Kirbiyik, Yasar B Kutbay, Berk Ozyilmaz, Taha R Ozdemir, Ozge Ozer Kaya, Gozde Kubat, Zeynep Peker Koc
BACKGROUND: Immunosuppression at the feto-maternal interface is crucial for a successful pregnancy outcome. Human leukocyte antigen-G (HLA-G) seems to be a major contributor to fetal tolerance. The HLA-G expression is seen in cytotrophoblasts and in maternal blood. Fetal HLA-G acts on decidual antigen-presenting cells (APCs), natural killers (NKs) and T cells. Recent findings revealed that defects in placentation and their consequences are associated with maternal HLA-G variants and their expression levels...
May 29, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Marise M Wagner, Mary M Beshay, Sophie Rooijakkers, Wietske Hermes, J Wouter Jukema, Saskia Le Cessie, Christianne J M De Groot, Bart E P B Ballieux, Jan M M Van Lith, Kitty W M Bloemenkamp
INTRODUCTION: Cardiovascular disease is the leading cause of death in women. Observational studies suggest that women with a history of recurrent miscarriage have an increased risk of cardiovascular disease. MATERIAL AND METHODS: Women who visited the recurrent miscarriage clinic at Leiden University Medical Centre (between 2000-2010) and had their third consecutive miscarriage < 31 years, were invited to participate in this follow-up study (between 2012-2014)...
May 28, 2018: Acta Obstetricia et Gynecologica Scandinavica
N Yazdani, M Shekari Khaniani, M Bastami, T Ghasemnejad, F Afkhami, S Mansoori Derakhshan
HLA-G is a nonclassical Class I major histocompatibility complex (MHC) gene. This gene has a limited protein alteration that is produced by alternative splicing and can be important in the preservation of pregnancy. Recent findings suggest that alteration in HLA-G gene expression can lead to pregnancy failure, such as recurrent pregnancy loss (RPL). As the promoter SNPs of the gene may impact the HLA-G expression levels, the study of these SNPs is very important. In this study, for the promoter region of HLA-G gene in the case group (100 women with a history of two or more repeated miscarriages) and the control group (100 women with at least two successful pregnancies), PCR reaction was performed...
May 24, 2018: International Journal of Immunogenetics
Yuanchang Zhu, Tonghua Wu, Lijun Ye, Guangui Li, Yong Zeng, Yaou Zhang
OBJECTIVE: To evaluate the association of two common methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with recurrent miscarriage (RM) and repeated implantation failure (RIF) METHODS: The study comprised of 521 patients, with a history of RM (n = 370) or RIF (n = 151). One hundred forty-four women with fallopian tube blockages who had successfully conceived after the first in vitro fertilization embryo transfer treatment served as the control group. The MTHFR alleles, genotypes, and haplotypes were assessed in different groups...
May 21, 2018: Journal of Assisted Reproduction and Genetics
Grażyna Kurzawińska, Justyna Magiełda, Anna Romała, Joanna Bartkowiak-Wieczorek, Magdalena Barlik, Krzysztof Drews, Marcin Ożarowski, Agnieszka Seremak-Mrozikiewicz
OBJECTIVES: Adequate folate intake constitutes a significant problem in the periconceptional period and early pregnancy but can be achieved by folic acid (FA) supplementation. Low intake of folate may cause numerous negative effects on the pregnancy outcome, including recurrent miscarriage, preeclampsia, fetal hypotrophy, premature delivery, premature placental abruption, and intrauterine fetal death. The aim of the study was to evaluate factors determining FA supplementation in the population of Polish women before and during pregnancy...
2018: Ginekologia Polska
Evren Gumus
The importance of apolipoprotein E genotypes and allelic polymorphisms in the etiology of recurrent miscarriage is controversial. We plan to investigate this in a two-group study involving more than a thousand participants. In total, 1046 subjects (802 participants in the first group, 244 participants in the second group) were investigated. Women in the first group had a history of ≥3 consecutive spontaneous miscarriage and women in the second group had at most one miscarriage in three consecutive pregnancies...
May 17, 2018: Gene
Yingyu Liu, Xiaoyan Chen, Jin Huang, Chi-Chiu Wang, Mei-Yung Yu, Susan Laird, Tin-Chiu Li
OBJECTIVE: To compare the prevalence of chronic endometritis (CE) when different diagnostic methods are used. DESIGN: Prospective observational study. SETTING: University-affiliated hospital. PATIENT(S): Four groups of women were studied, including women with proven fertility (Fertile; n = 40), unexplained recurrent miscarriage (RM; n = 93), recurrent implantation failure (RIF; n = 39), and infertile subjects undergoing endometrial scratch in a natural cycle preceding frozen-thawed embryo transfer (Infertility; n = 48)...
May 2018: Fertility and Sterility
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