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https://www.readbyqxmd.com/read/29473992/radical-prostatectomy-and-the-effect-of-close-surgical-margins-results-from-the-search-database
#1
Christine Herforth, Sean P Stroup, Zinan Chen, Lauren E Howard, Stephen J Freedland, Daniel M Moreira, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Christopher J Kane
OBJECTIVE: Positive surgical margins (PSM) after radical prostatectomy (RP) are a significant predictor of biochemical failure and possible disease progression. Close surgical margins (CSM) however represent a diagnostic challenge for surgeons. We sought to evaluate the biochemical recurrence (BCR) patterns among men undergoing RP with specimens having negative, positive, and close surgical margins from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Men undergoing RP between 1988 and 2015 with known final pathologic margin status were evaluated...
February 23, 2018: BJU International
https://www.readbyqxmd.com/read/29472949/the-relationship-between-motor-imitation-and-early-social-communication-skills-in-children-with-autism
#2
Hooshang Dadgar, Javad Alaghband Rad, Zahra Soleymani, Anahita Khorammi, Joe McCleery, Saman Maroufizadeh
Objective: Development of early social skills in children is a complex process. To understand this process, it is important to assess how strengths or weaknesses in other developmental domains may be affected by these skills. The present study aimed at investigating the association of motor skills and imitation ability with early social communication skills in children with autism spectrum disorder (ASD). Method: In this study, 20 children with ASD aged 3 to 5 years (M = 4.05, SD = 0.55) participated. All children were diagnosed as ASD based on the DSM-V criteria by an independent child psychiatrist...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472948/craving-and-drug-reward-a-comparison-of-celecoxib-and-ibuprofen-in-detoxifying-opiate-addicts
#3
Sara Jafari, Sana Khajehpour, Emran Mohammad Razzaghi, Kazem Heidari, Mehdi Soleimani, Padideh Ghaeli
Objective: Craving for substance abuse is a usual and complicated problem in patients, with opioid addiction who are in opioid detoxifying process. Craving has been added as one of the diagnostic criteria of substance use disorders in DSM-5. The present trial aimed at comparing the effects of celecoxib versus ibuprofen in reducing pain and decreasing the desire to use opiates in patients undergoing opiate detoxification (n = 32). Method: A total of 32 patients (both inpatients and outpatients), who were undergoing opiate detoxification procedure and met the inclusion criteria entered this 4- week study...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472947/comparison-of-the-prevalence-of-psychiatric-disorders-in-performance-enhancing-drug-users-and-nonuser-bodybuilders
#4
Afshin Ostovar, Mohammad Javad Haerinejad, Samad Akbarzadeh, Mojtaba Keshavarz
Objective: The present study aimed at comparing the prevalence of major psychiatric disorders including major depressive disorder, bipolar disorder, schizophrenia, and generalized anxiety disorder between performance-enhancing drug users and nonuser bodybuilders. Moreover, the prevalence of major psychiatric disorders in bodybuilders was also reported. Method: In this study, 453 athletes were recruited from Bushehr bodybuilding gyms from February to May 2015. A structured questionnaire was used to collect the participants' information, including demographic characteristics, sports' status and performance-enhancing drug use...
October 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29472889/clinical-and-magnetic-resonance-imaging-findings-of-neurotoxocariasis
#5
REVIEW
Sofia S Sánchez, Hector H García, Alessandra Nicoletti
Human toxocariasis is one of the most prevalent helminthiases worldwide. Toxocara canis larvae can cross the blood-brain barrier leading to the neurotoxocariasis. The clinical presentation consists of a wide spectrum of neurological manifestations, but asymptomatic infection is probably common. Neurotoxocariasis is not a frequent diagnosis probably due to the non-specific nature of its symptoms as well as the lack of confirmatory diagnostic tests. Diagnosis of neurotoxocariasis is based on the presence of a high titer of anti- Toxocara antibody in the cerebrospinal fluid or in the serum, presence of eosinophilia in the serum or cerebrospinal fluid, and clinical and radiological improvement after anthelmintic therapy; however, universally accepted diagnostic criteria are lacking...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29472163/validation-of-an-algorithm-based-definition-of-treatment-resistance-in-patients-with-schizophrenia
#6
Olesya Ajnakina, Henriette Thisted Horsdal, John Lally, James H MacCabe, Robin M Murray, Christiane Gasse, Theresa Wimberley
Large-scale pharmacoepidemiological research on treatment resistance relies on accurate identification of people with treatment-resistant schizophrenia (TRS) based on data that are retrievable from administrative registers. This is usually approached by operationalising clinical treatment guidelines by using prescription and hospital admission information. We examined the accuracy of an algorithm-based definition of TRS based on clozapine prescription and/or meeting algorithm-based eligibility criteria for clozapine against a gold standard definition using case notes...
February 19, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29472022/is-food-protein-induced-enterocolitis-syndrome-only-a-non-ige-mediated-food-allergy
#7
S Miceli Sopo, C Fantacci, G Bersani, A Romano, L Liotti, S Monaco
Food protein induced enterocolitis syndrome (FPIES) is classified as non-IgE-mediated or cell-mediated food allergy, although there is an atypical phenotype so defined for the presence of specific IgEs. All diagnostic criteria for FPIES include the absence of skin or respiratory symptoms of IgE-mediated type. We present four cases that suggest that specific IgEs may have a pathogenic role, resulting in the existence of different FPIES phenotypes. This could be important from a diagnostic and therapeutic point of view...
February 19, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29471816/idiopathic-pulmonary-fibrosis-pathogenesis-and-management
#8
REVIEW
Giacomo Sgalla, Bruno Iovene, Mariarosaria Calvello, Margherita Ori, Francesco Varone, Luca Richeldi
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor prognosis. This review will present the substantial advances achieved in the understanding of IPF pathogenesis and in the therapeutic options that can be offered to patients, and will address the issues regarding diagnosis and management that are still open. MAIN BODY: Over the last two decades much has been clarified about the pathogenic pathways underlying the development and progression of the lung scarring in IPF...
February 22, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29471722/outcomes-and-resource-use-among-overweight-and-obese-children-with-sepsis-in-the-pediatric-intensive-care-unit
#9
Laura S Peterson, Cecilia Gállego Suárez, Hannah E Segaloff, Cameron Griffin, Emily T Martin, Folafoluwa O Odetola, Kanakadurga Singer
OBJECTIVE: To evaluate the effect of overweight and obesity on outcomes and resource use among patients with sepsis in the pediatric intensive care unit (PICU). DESIGN: Retrospective analysis of clinical characteristics, resource use, and mortality among children 0 to 20 years of age admitted to the C.S. MottChildren's Hospital PICU (University of Michigan) between January 2009 and December 2015, with a diagnostic code for sepsis at admission (based on International Classification of Diseases, Ninth Revision- Clinical Modification codes) and with weight and height measurements at PICU admission...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29471686/annals-express-comparison-of-hba1c-and-glycated-albumin-as-a-control-marker-for-newborn-complications-from-diabetic-women-in-a-multicenter-study-in-japan-japan-glycated-albumin-study-group-study2
#10
Ikki Shimizu, Yuji Hiramatsu, Yasue Omori, Masao Nakabayashi
Background:To clarify the relationship between glycated hemoglobin (HbA1c) and glycated albumin (GA) levels during pregnancy with neonatal outcomes, a multicenter study was conducted by the Japanese Society of Diabetes and Pregnancy. Methods:A total of 136 patients (type 1: n = 47, type 2: n = 89) who enrolled in the study were diagnosed based on the Japanese Diabetes Society diagnostic criteria for diabetes mellitus. Thresholds for HbA1c and GA were set at 5.8 % and 15.8 %, respectively, as the upper limits of the normal reference interval in pregnant women...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29471142/hair-analysis-when-external-contamination-is-in-question-a-review-of-practical-approach-for-the-interpretation-of-results
#11
Lolita Tsanaclis, Maristela Andraus, John Wicks
Despite having been extensively discussed over the last decade, the differentiation between systemic exposure and external contamination still continues to be one of the limitations of hair testing for drugs. For this reason, we consider it worthwhile to re-state some basic principles in this short review. Various studies investigating a diversity of wash protocols, most using artificially contaminated hair with cocaine, have been valuable in evaluating wash efficacy and in understanding the incorporation of drugs in hair...
February 7, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29470861/mini-cog-for-the-diagnosis-of-alzheimer-s-disease-dementia-and-other-dementias-within-a-primary-care-setting
#12
REVIEW
Dallas P Seitz, Calvin Ch Chan, Hailey T Newton, Sudeep S Gill, Nathan Herrmann, Nadja Smailagic, Vasilis Nikolaou, Bruce A Fage
BACKGROUND: Alzheimer's disease and other forms of dementia are becoming increasingly common with the aging of most populations. The majority of individuals with dementia will first present for care and assessment in primary care settings. There is a need for brief dementia screening instruments that can accurately diagnose dementia in primary care settings. The Mini-Cog is a brief, cognitive screening test that is frequently used to evaluate cognition in older adults in various settings...
February 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29470247/hypofibrinogenemia-is-associated-with-poor-outcome-and-secondary-hemophagocytic-lymphohistiocytosis-macrophage-activation-syndrome-in-pediatric-severe-sepsis
#13
Jessica K Signoff, Julie C Fitzgerald, David T Teachey, Fran Balamuth, Scott L Weiss
OBJECTIVES: Some children with sepsis exhibit a sustained hyperinflammatory response that can trigger secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. Although hypofibrinogenemia is a shared feature of sepsis and hemophagocytic lymphohistiocytosis, there are no data about fibrinogen as a biomarker to identify children with sepsis/secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome overlap. We hypothesized that hypofibrinogenemia is associated with poor outcomes and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome and has utility as a screening biomarker for this sepsis phenotype...
February 21, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29470227/hospitalized-patients-with-and-without-hemodialysis-have-markedly-different-vancomycin-pharmacokinetics-a-population-pharmacokinetic-model-based-analysis
#14
V Goti, A Chaturvedula, M J Fossler, S Mok, J T Jacob
BACKGROUND: Despite being in clinical use for about six decades, vancomycin dosing remains perplexing and complex. METHODS: A population pharmacokinetic modeling and simulation approach was used to evaluate the efficiency of the current nomogram-based dosing of vancomycin. Serum vancomycin concentrations were obtained as a part of routine therapeutic drug monitoring (TDM) from two 500-bed academic medical centers. A population pharmacokinetic model was first built using these TDM data...
February 20, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29470096/the-psychometric-properties-sensitivity-and-specificity-of-the-geriatric-anxiety-inventory-hospital-anxiety-and-depression-scale-and-rating-anxiety-in-dementia-scale-in-aged-care-residents
#15
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVES: Limited research has been conducted into the identification of a valid and reliable screening measure for anxiety in aged care settings, despite it being one of the most common psychological conditions. This study aimed to determine an appropriate anxiety screening tool for aged care by comparing the reliability and validity of three commonly used measures and identifying specific cut-offs for the identification of generalized anxiety disorder (GAD). METHOD: One-hundred and eighty nursing home residents (M age = 85...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29469908/limited-jaw-movements-and-somatization-but-not-pain-may-play-a-role-in-salivary-flow-in-female-patients-with-temporomandibular-disorders
#16
Irena Mladenovic, Jelena Krunic, Nikola Stojanovic, Dusanka Markovic, Silvia Rdt de Siqueira
AIMS: To explore the unstimulated salivary flow rate and subjective feeling of oral dryness in young adult women with temporomandibular disorders (TMD) and their relation to the presence of chronic pain, depression, somatization, and limited mandibular mobility. METHODS: Unstimulated whole saliva flow rate and presence of oral dryness were determined in 45 women with TMD and 30 healthy controls. The Research Diagnostic Criteria for TMD (RDC/TMD) were used for assessment of TMD, chronic pain, depression, somatization, and mandibular mobility...
February 21, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29469775/coexistence-of-keloids-and-pilomatricoma-in-a-patient-with-rubinstein-taybi-syndrome
#17
Yosuke Yagi, Yutaka Kuwatsuka, Misachi Asai, Mai Honda, Atsushi Utani
Rubinstein-Taybi syndrome (RTS) is an autosomaldominant hereditary disease, which contains many skeletal and organ anomalies as well as mental retardation. Although high incidence of keloids in RTS is known, it is difficult to find a detailed report on the clinical features of keloids. In the following letter, we report an RTS patient fulfilling diagnostic criteria whosuffered from both keloids and pilomatricoma. We also performed a literature search, which identified the possible involvement of the Wnt/β-catenin signaling pathway in the pathogenesis of these two skin lesions...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469344/-interpretation-of-diagnostic-criteria-for-kala-azar
#18
Wang Jun-Yun, Gao Chun-Hua
Kala-azar was once transmitted in the northern area of the Yangtze River in China, including 16 provinces (cities or autonomous regions). Through the great continuing prevention and control effort, this disease has been effectively controlled in the most of endemic areas. However, because the epidemic factors of the disease are complex, this disease still transmits or sporadically occurs in the western part of China, including 60 counties of Xinjiang, Gansu, Sichuan, Inner Mongolia, Shanxi, and Shaanxi provinces (autonomous regions)...
October 16, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469343/-interpretation-of-diagnostic-criteria-for-clonorchiasis
#19
Chen Ying-Dan, Zhu Ting-Jun, Xu Long-Qi, Zhen Bin, Xiong Yan-Hong, Zhou Chang-Hai
Clonorchis sinensis infection is carcinogenic to human, which results in cholangiocarcinoma, confirmed by the World Health Organization. An investigation in 2005 indicated that the standardized C. sinensis infection rate was 0.58%, with 12 490 000 infected people estimated in the clonorchiasis endemic areas in China. In the world, 80% of C. sinensis infected people were distributed in China. Diagnostic Criteria for Clonorchiasis (WS309-2009) was compiled by the ex-Ministry of Health of the People's Republic of China and it was issued and implemented in March 13, 2009...
October 17, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29468524/tafro-syndrome-with-refractory-thrombocytopenia-responding-to-tocilizumab-and-romiplostim-a-case-report
#20
Shoko Noda-Narita, Keiichi Sumida, Akinari Sekine, Junichi Hoshino, Koki Mise, Tatsuya Suwabe, Noriko Hayami, Masayuki Yamanouchi, Toshiharu Ueno, Hiroki Mizuno, Masahiro Kawada, Rikako Hiramatsu, Eiko Hasegawa, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Takeshi Fujii, Yoshifumi Ubara
Thrombocytopenia, anasarca, fever, reticulin fibrosis, organomegaly (TAFRO) syndrome is a unique clinicopathologic subtype of multicentric Castleman's disease that has recently been identified in Japan. However, little is known about its renal histological changes and the optimal treatment for TAFRO syndrome. An 80-year-old Japanese woman was admitted to our hospital for evaluation of severe anasarca and weight gain (10 kg in a month). She had polyneuropathy, monoclonal plasma cell proliferative disorder with positive kappa M-protein, a sclerotic bone lesion, elevation of vascular endothelial growth factor (VEGF), skin changes, and extravascular volume overload, which fulfilled the diagnostic criteria for POEMS (polyneuropathy, organomegaly, endocrinopathy, and monoclonal protein, skin changes) syndrome...
February 21, 2018: CEN Case Reports
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