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https://www.readbyqxmd.com/read/29656215/inter-observer-variance-and-the-need-for-standardization-in-the-morphological-classification-of-myelodysplastic-syndrome
#1
Keiko Sasada, Noriko Yamamoto, Hiroki Masuda, Yoko Tanaka, Ayako Ishihara, Yasushi Takamatsu, Yutaka Yatomi, Waichiro Katsuda, Issei Sato, Hirotaka Matsui
In this era of genome medicine, the sub-classification of myeloid neoplasms, including myelodysplastic syndrome (MDS), is now supported by genetic testing in selected cases. However, as the initial suspicion and primary diagnosis of the disease still largely relies on morphological features and numbers of hematopoietic cells, the establishment of a uniform diagnostic basis, especially for cell morphology, is essential. In this study, we collected nearly 100,000 hematopoietic cell images from 499 peripheral blood smear specimens from patients with MDS and used these to evaluate the standardization of morphological classification by medical technologists...
April 9, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29656018/systematic-analysis-of-the-cerebrospinal-fluid-proteome-of-fibromyalgia-patients
#2
Payam Emami Khoonsari, Sravani Musunri, Stephanie Herman, Camilla I Svensson, Lars Tanum, Torsten Gordh, Kim Kultima
Fibromyalgia (FM) is a syndrome characterized by widespread muscular pain, fatigue and functional symptoms, which is known to be difficult to diagnose as the various symptoms overlap with many other conditions. Currently, there are no biomarkers for FM, and the diagnosis is made subjectively by the clinicians. We have performed shotgun proteomics on cerebrospinal fluid (CSF) from FM patients and non-pain controls to find potential biomarker candidates for this syndrome. Based on our multivariate and univariate analyses, we found that the relative differences in the CSF proteome between FM patients and controls were moderate...
April 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29653162/inconsistency-in-the-definition-of-urinary-tract-infection-after-intravesical-botulinum-toxin-a-injection-a-systematic-review
#3
Andrew W Stamm, Sarah A Adelstein, Andrew Chen, Alvaro Lucioni, Kathleen C Kobashi, Una J Lee
PURPOSE: In order to more accurately examine the rate of urinary tract infection following onabotulinumtoxinA injection of the bladder, we systematically reviewed the literature for definitions of urinary tract infection utilized in series that reported on onabotulinumtoxinA injections and assessed them for consistency with guideline statements defining urinary tract infections. MATERIALS AND METHODS: A systematic review of the literature was performed via query using MEDLINE and EMBASE...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29653121/integration-and-diagnostic-accuracy-of-3t-non-endorectal-coil-prostate-mri-in-the-context-of-active-surveillance
#4
Nicole E Curci, Brian R Lane, Prasad R Shankar, Sabrina L Noyes, Andrew K Moriarty, Anthony Kubat, Chris Brede, Jeffrey S Montgomery, Gregory B Auffenberg, David C Miller, James E Montie, Arvin K George, Matthew S Davenport
OBJECTIVE: To evaluate the integration of 3T non-endorectal-coil multiparametric prostate MRI (mpMRI) at two high-volume practices that routinely use mpMRI in the setting of active surveillance. MATERIALS AND METHODS: This was an IRB-approved, HIPAA-compliant, dual-institution retrospective cohort study. Subjects undergoing 3T mpMRI without endorectal coil at either study institution over a 13-month period (8/1/2015-8/31/2016) were selected based on pre-defined criteria: clinical T1/T2 Gleason 6 prostate cancer, PSA<15 ng/mL, ≥40 years-old, mpMRI within 2 years of prostate biopsy, PI-RADS v2 score assigned...
April 10, 2018: Urology
https://www.readbyqxmd.com/read/29653011/-advance-in-clinical-research-on-antley-bixler-syndrome
#5
Min Xie, Hongying Wang, Linqi Chen, Haibo Li, Hong Li
Antley-Bixler syndrome (ABS) is a rare childhood disorder affecting skeletal development. Some patients may also have genital anomalies and impaired steroidogenesis. Diagnostic criteria for ABS has not been fully established, though craniosynostosis, midface hypoplasia and elbow synostosis are minimum requirements. The etiology of ABS is complex, which included autosomal dominant form caused by FGFR2 gene mutations, autosomal recessive form caused by POR gene mutations, and high oral dose of fluconazole during pregnancy...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652947/-predictors-of-remission-from-major-depressive-disorder-in-secondary-care
#6
Lilian Salvo, Sandra Saldivia, Carlos Parra, Manuel Cifuentes, Claudio Bustos, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
Background The knowledge of predictive factors in depression should help to deal with the disease. Aim To assess potential predictors of remission of major depressive disorders (MDD) in secondary care and to propose a predictive model. Material and Methods A 12 month follow-up study was conducted in a sample of 112 outpatients at three psychiatric care centers of Chile, with baseline and quarterly assessments. Demographic, psychosocial, clinical and treatment factors as potential predictors, were assessed. A clinical interview with the checklist of DSM-IV diagnostic criteria, the Hamilton Depression Scale and the List of Threatening Experiences and Multidimensional Scale of Perceived Social Support were applied...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29652945/clinical-evaluation-and-validation-of-laboratory-methods-for-the-diagnosis-of-bordetella-pertussis-infection-culture-polymerase-chain-reaction-pcr-and-anti-pertussis-toxin-igg-serology-igg-pt
#7
Adria D Lee, Pamela K Cassiday, Lucia C Pawloski, Kathleen M Tatti, Monte D Martin, Elizabeth C Briere, M Lucia Tondella, Stacey W Martin
INTRODUCTION: The appropriate use of clinically accurate diagnostic tests is essential for the detection of pertussis, a poorly controlled vaccine-preventable disease. The purpose of this study was to estimate the sensitivity and specificity of different diagnostic criteria including culture, multi-target polymerase chain reaction (PCR), anti-pertussis toxin IgG (IgG-PT) serology, and the use of a clinical case definition. An additional objective was to describe the optimal timing of specimen collection for the various tests...
2018: PloS One
https://www.readbyqxmd.com/read/29652881/the-simultaneous-assessment-of-glycosylated-hemoglobin-fasting-plasma-glucose-and-oral-glucose-tolerance-test-does-not-improve-the-detection-of-type-2-diabetes-mellitus-in-colombian-adults
#8
Jose Lopez-Lopez, Jennifer Garay, Edwin Wandurraga, Paul A Camacho, Fernando Higuera-Escalante, Daniel Cohen, Patricio Lopez-Jaramillo
INTRODUCTION: Guidelines recommend early detection of type 2 diabetes mellitus (DM2). The objective of the present study was to evaluate the capacity to identify DM2 in subjects that were screened for DM2 simultaneously with all three of the tests recommended-fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and a 2-hour post 75-g oral glucose tolerance test (OGTT). METHODS AND RESULTS: The present analysis of an anonymous database of 1113 adults from a reference clinical laboratory in Bucaramanga, Colombia, was an observational, descriptive, cross-sectional secondary source study...
2018: PloS One
https://www.readbyqxmd.com/read/29652314/-cervical-vertigo-a-neurologist-s-point-of-view
#9
I D Stulin, M V Tardov, N L Kunelskaya, L G Agasarov, A V Boldin
Cervical vertigo (CV) hasn't yet been recognized by many neurologists, as it has no specific clinical symptoms and reliable diagnostic criteria. However, over the past 150 years, there has been accumulated numerous experimental and clinical evidence to support the legitimacy of CV allocation as a separate nosology. This review presents data regarding the vertigo associated with neck pathology: possible evidence of CV existence and the description of its type as well. The principles of CV diagnosis and treatment are considered, an attempt to create a unified concept is proposed...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29652310/-latent-dysphoria-an-instrument-of-screening-and-diagnosis-preliminary-results
#10
M A Morozova, A A Alekseev, G E Rupchev
AIM: Latent dysphoria is a kind of emotional disorder. Its key features are floating feeling of dissatisfaction and irritability accompanied with suppression of expression of these emotions. The article is devoted to the development of a screening diagnostic tool (checklist) to screen and evaluate patients with this emotional problem. MATERIAL AND METHODS: Three hundred and ninety-four neurologists (outpatient segment) were surveyed to assess the prevalence of an emotional disorder that met criteria of latent dysphoria suggested by the authors...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29652208/age-based-ultrasonographic-criteria-for-diagnosis-of-autosomal-dominant-polycystic-kidney-disease-in-persian-cats
#11
Juliana M Guerra, Mariana F Freitas, Alexandre Gt Daniel, Arine Pellegrino, Natália C Cardoso, Isac de Castro, Luiz F Onuchic, Bruno Cogliati
Objectives The aim of this study was to establish ultrasound criteria for the diagnosis of autosomal dominant polycystic kidney disease (ADPKD) in Persian cats. Methods Eighty-two Persian cats were assessed using renal ultrasound and genotyped for the C→A transversion in exon 29 of PKD1. The animals were also submitted to hematological characterization, serum biochemistry analyses and urinalysis. Results Age, sex and neutering status did not differ between ADPKD (n = 12) and non-ADPKD (n = 70) cats. After integrated molecular genetics/ultrasonographic analysis, the presence of at least one renal cyst was sufficient to establish a diagnosis of ADPKD in animals up to 15 months of age...
April 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29652114/associations-between-vitamin-d-levels-and-polycystic-ovary-syndrome-pcos-phenotypes
#12
Erin M Davis, Jennifer D Peck, Karl R Hansen, Barbara R Neas, LaTasha B Craig
BACKGROUND: Studies comparing serum 25-hydroxyvitamin D concentrations in women with and without PCOS have produced inconsistent results. Additionally, no previous studies have evaluated associations between vitamin D and specific PCOS phenotypes. METHODS: This case-control study was conducted among women undergoing intrauterine insemination. Cases (n=137) were diagnosed with PCOS and then further classified into 3 diagnostic phenotypes based on combinations of the Rotterdam criteria [ovulatory dysfunction +polycystic ovaries (n=55); ovulatory dysfunction +androgen excess (n=15); and ovulatory dysfunction, +polycystic ovaries, +androgen excess (n=67)]...
April 12, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29652034/prevalence-of-sleep-disorder-in-irritable-bowel-syndrome-a-systematic-review-with-meta-analysis
#13
Ben Wang, Ruqiao Duan, Liping Duan
Background/Aims: We conducted this meta-analysis to evaluate the prevalence of sleep disorder in irritable bowel syndrome (IBS) patients and study the association between IBS and sleep disorder. Materials and Methods: A systematic search was conducted by searching PubMed, Embase, and Cochrane library databases using the following search terms: "functional gastrointestinal disorders," "Sleep disturbance," "Sleep disorder," "insomnia," "Dysomnias," "irritable bowel syndrome," and "IBS...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29652029/evaluation-of-a-modified-rat-model-for-functional-dyspepsia
#14
Qiankun Liang, Yuan Yan, Lanfang Mao, Xiaojuan Du, Jingjing Liang, Junhong Liu, Longde Wang, Hongfang Li
Background/Aim: The purpose of this study was to establish a modified rat model with functional dyspepsia (FD) and analyze the changes in gastrointestinal motility and brain-gut peptide levels in serum and brain-gut axis. Materials and Methods: Male Wistar rats were divided into control group (Con) and FD model group. FD model was established by stimulating semi-starvation rats via tail damping, provocation, and forced exercise fatigue until gastrointestinal motility disorder appeared, and then levels of motilin, leptin, cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were detected in serum by enzyme linked immunosorbent assay and in duodenum, antrum, and hypothalamus by immunohistochemistry, reverse transcriptase-polymerase chain reaction, and Western blot...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29651981/lamotrigine-for-people-with-borderline-personality-disorder-a-rct
#15
Mike J Crawford, Rahil Sanatinia, Barbara Barrett, Gillian Cunningham, Oliver Dale, Poushali Ganguli, Geoff Lawrence-Smith, Verity C Leeson, Fenella Lemonsky, Georgia Lykomitrou-Matthews, Alan Montgomery, Richard Morriss, Jasna Munjiza, Carol Paton, Iwona Skorodzien, Vineet Singh, Wei Tan, Peter Tyrer, Joseph G Reilly
BACKGROUND: No drug treatments are currently licensed for the treatment of borderline personality disorder (BPD). Despite this, people with this condition are frequently prescribed psychotropic medications and often with considerable polypharmacy. Preliminary studies have indicated that mood stabilisers may be of benefit to people with BPD. OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of lamotrigine for people with BPD. DESIGN: A two-arm, double-blind, placebo-controlled individually randomised trial of lamotrigine versus placebo...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29651772/monitoring-neurointerventional-radiation-doses-using-dose-tracking-software-implications-for-the-establishment-of-local-diagnostic-reference-levels
#16
Holly Acton, Karl James, Richard G Kavanagh, Colm O'Tuathaigh, Deirdre Moloney, Gerald Wyse, Noel Fanning, Michael Maher, Owen J O'Connor
OBJECTIVES: There is potential for high radiation exposure during neurointerventional procedures. Increasing regulatory requirements mandate dose monitoring of patients and staff, and justification of high levels of radiation exposure. This paper demonstrates the potential to use radiation dose-tracking software to establish local diagnostic reference levels. METHODS: Consecutive neurointerventional procedures, performed in a single institution within a one-year period, were retrospectively studied...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651720/biomarkers-study-in-atypical-dementia-proof-of-a-diagnostic-work-up
#17
Gemma Lombardi, Cristina Polito, Valentina Berti, Camilla Ferrari, Giulia Lucidi, Silvia Bagnoli, Irene Piaceri, Benedetta Nacmias, Alberto Pupi, Sandro Sorbi
An early differentiation between Alzheimer's Disease (AD) and other dementias is crucial for an adequate patients' management, albeit it may result difficult for the occurrence of "atypical presentations." Current diagnostic criteria recognize the importance of biomarkers for AD diagnosis, but still an optimal diagnostic work-up isn't available. Evaluate the utility and reproducibility of biomarkers and propose an "optimal" diagnostic work-up in atypical dementia: (1) a retrospective selection of "atypical dementia cases"; (2) a repetition of diagnostic assessment by two neurologists following two different diagnostic work-ups, each consisting of multiple steps; (3) a comparison between diagnostic accuracy and confidence reached at each step by both neurologists and evaluation of the inter-rater agreement...
April 13, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29651302/common-mental-disorders-and-psychological-adjustment-among-individuals-seeking-hiv-testing-a-study-protocol-to-explore-implications-for-mental-health-care-systems
#18
Jason Bantjes, Ashraf Kagee
Background: In an effort to promote greater access to voluntary counseling and testing for HIV, it has become practice in many countries, including South Africa, to establish non-medical testing sites and to de-couple HIV testing from other medical and mental health care services. While it is well established that HIV infection is associated with a range of psychopathology, much of the literature has assumed that it is receipt of an HIV positive diagnosis that causes people to become depressed, traumatized, or develop other psychiatric symptoms...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29650983/myotube-elasticity-of-an-amyotrophic-lateral-sclerosis-mouse-model
#19
Béla Varga, Marta Martin-Fernandez, Cécile Hilaire, Ana Sanchez-Vicente, Julie Areias, Céline Salsac, Frédéric J G Cuisinier, Cédric Raoul, Frédérique Scamps, Csilla Gergely
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor system leading to generalized paralysis and death of patients. The understanding of early pathogenic mechanisms will help to define early diagnostics criteria that will eventually provide basis for efficient therapeutics. Early symptoms of ALS usually include muscle weakness or stiffness. Therefore, mechanical response of differentiated myotubes from primary cultures of mice, expressing the ALS-causing SOD1 G93A mutation, was examined by atomic force microscopy...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650787/management-of-small-unruptured-intracranial-aneurysms-a-survey-of-neuroradiologists
#20
A Malhotra, X Wu, B Geng, D Hersey, D Gandhi, P Sanelli
BACKGROUND AND PURPOSE: The long-term history and management of unruptured intracranial aneurysms is not well understood. Our aim was to determine current practice patterns in the management of unruptured intracranial aneurysms, especially regarding imaging surveillance for conservatively managed aneurysms of this type. MATERIALS AND METHODS: An on-line survey was designed to examine physician practice and preference regarding the management of small unruptured intracranial aneurysms (≤7 mm in diameter)...
April 12, 2018: AJNR. American Journal of Neuroradiology
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