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https://www.readbyqxmd.com/read/28441637/subtle-pathological-changes-in-neocortical-temporal-lobe-epilepsy
#1
Juan G Ochoa, Diana Hentgarden, Audrey Paulzak, Melissa Ogden, Richard Pryson, Markus Lamle, Walter G Rusyniak
This was a prospective observational study to correlate the clinical symptoms, electrophysiology, imaging, and surgical pathology of patients with temporal lobe epilepsy (TLE) without hippocampal sclerosis. We selected consecutive patients with TLE and normal MRI undergoing temporal lobe resection between April and September 2015. Clinical features, imaging, and functional data were reviewed. Intracranial monitoring and language mapping were performed when it was required according to our team recommendation...
April 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28441386/graft-derived-cell-free-dna-a-noninvasive-early-rejection-and-graft-damage-marker-in-liver-transplantation-a-prospective-observational-multicenter-cohort-study
#2
Ekkehard Schütz, Anna Fischer, Julia Beck, Markus Harden, Martina Koch, Tilo Wuensch, Martin Stockmann, Björn Nashan, Otto Kollmar, Johannes Matthaei, Philipp Kanzow, Philip D Walson, Jürgen Brockmöller, Michael Oellerich
BACKGROUND: Graft-derived cell-free DNA (GcfDNA), which is released into the blood stream by necrotic and apoptotic cells, is a promising noninvasive organ integrity biomarker. In liver transplantation (LTx), neither conventional liver function tests (LTFs) nor immunosuppressive drug monitoring are very effective for rejection monitoring. We therefore hypothesized that the quantitative measurement of donor-derived cell-free DNA (cfDNA) would have independent value for the assessment of graft integrity, including damage from acute rejection...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28440858/treatment-with-disease-modifying-drugs-for-people-with-a-first-clinical-attack-suggestive-of-multiple-sclerosis
#3
REVIEW
Graziella Filippini, Cinzia Del Giovane, Marinella Clerico, Omid Beiki, Miriam Mattoscio, Federico Piazza, Sten Fredrikson, Irene Tramacere, Antonio Scalfari, Georgia Salanti
BACKGROUND: The treatment of multiple sclerosis has changed over the last 20 years. The advent of disease-modifying drugs in the mid-1990s heralded a period of rapid progress in the understanding and management of multiple sclerosis. With the support of magnetic resonance imaging early diagnosis is possible, enabling treatment initiation at the time of the first clinical attack. As most of the disease-modifying drugs are associated with adverse events, patients and clinicians need to weigh the benefit and safety of the various early treatment options before taking informed decisions...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28440855/accuracy-of-current-diagnostic-criteria-for-acute-bacterial-infection-in-older-adults-in-the-emergency-department
#4
Jeffrey M Caterino, Robert Leininger, David M Kline, Lauren T Southerland, Salman Khaliqdina, Christopher W Baugh, Daniel J Pallin, Kurt B Stevenson
OBJECTIVES: To compare the accuracy of the Loeb criteria, emergency department (ED) physicians' diagnoses, and Centers for Disease Control and Prevention (CDC) guidelines for acute bacterial infection in older adults with a criterion standard expert review. DESIGN: Prospective, observational study. SETTING: Urban, tertiary-care ED. PARTICIPANTS: Individuals aged 65 and older in the ED, excluding those who were incarcerated, underwent a trauma, did not speak English, or were unable to consent...
April 25, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28440672/definitions-and-participant-characteristics-of-frequent-recurrent-headache-types-in-clinical-trials-a-systematic-review
#5
Maria-Eliza R Aguila, Trudy Rebbeck, Kristofferson G Mendoza, Mary-Grace L De La Peña, Andrew M Leaver
Background Clear definitions of study populations in clinical trials may facilitate application of evidence to clinical populations. This review aimed to explore definitions of study populations in clinical trials on migraine, tension-type headache, cluster headache, and cervicogenic headache. Methods We performed a systematic review of clinical trials investigating treatment efficacy for migraine, tension-type headache, cluster headache, and cervicogenic headache. We extracted data on diagnosis, inclusion criteria and baseline headache characteristics...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28440538/massive-nasal-polyposis-in-a-patient-with-newly-diagnosed-cystic-fibrosis
#6
Małgorzata Olszowiec-Chlebna, Krzysztof Trzciński, Iwona Stelmach
INTRODUCTION: Cystic fibrosis (CF) - is the most common fatal autosomal recessive disease in Caucasians. A number of reports have described patients who do not meet diagnostic criteria for cystic fibrosis. Atypical or nonclassic CF is characterised by normal or borderline sweat test, pancreatic sufficiency and a monosymptomatic phenotype. For these reasons clinicians should remain alert to the possibility of the occurrence of CF. CASE REPORT: We described a case presentation of massive nasal polyposis and recurrent sinusitis leading to the diagnosis ofcystic fibrosis in a 11-year-old male...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28440346/imaging-of-intrahepatic-progression-of-hepatocellular-carcinoma-post-transarterial-chemoembolization-a-long-term-prospective-evaluation-of-contrast-enhanced-ultrasonography-ceus
#7
Hippocrates Moschouris, Mariana Kalokairinou-Motogna, Spyros Vrakas, Aggeliki Papadatou, Eyaggelos Karagiannis, Michail Kiltenis, Konstantinos Kladis-Kalentzis, Kyriaki Marmaridou, Nikolaos Papadogeorgopoulos, Katerina Malagari
AIMS: To assess the diagnostic efficacy of contrast-enhanced ultrasonography (CEUS) in the context of intrahepatic progression (IHP) of hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). MATERIAL AND METHODS: Sixty HCC patients were prospectively included in the study. They were treated with transarterial chemoembolization (TACE)with doxorubicin-eluting microspheres (231 sessions). Imaging follow-up was performed 1 month after each session and at 3-6 month intervals after the last session of TACE and included CEUS and contrast-enhanced magnetic resonance (MR) imaging (reference modality)...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28440098/early-diagnosis-of-amyotrophic-lateral-sclerosis-mimic-syndromes-pros-and-cons-of-current-clinical-diagnostic-criteria
#8
Elena Cortés-Vicente, Jesús Pradas, Juan Marín-Lahoz, Noemi De Luna, Jordi Clarimón, Janina Turon-Sans, Ellen Gelpí, Jordi Díaz-Manera, Isabel Illa, Ricard Rojas-Garcia
OBJECTIVE: To describe the frequency and clinical characteristics of patients referred to a tertiary neuromuscular clinic as having amyotrophic lateral sclerosis (ALS) but who were re-diagnosed as having an ALS mimic syndrome, and to identify the reasons that led to the revision of the diagnosis. METHODS: We reviewed the final diagnosis of all patients prospectively registered in the Sant Pau-MND register from 1 January 2004 to 31 December 2015. A detailed clinical evaluation and a clinically-guided electrophysiological study were performed at first evaluation...
April 25, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28440088/head-and-neck-giant-cell-arteritis-an-autoimmune-disease-with-many-faces
#9
Markus Wirth, Lucas Schirmer, Benedikt Hofauer, Magdalena Lenschow, Daria Loos, Klaus Thuermel, Andreas Knopf
CONCLUSION: A high rate of infrequent presentations of giant cell arteritis were seen in the ENT department and should be anticipated as a differential diagnosis in every older patient with odynophagia with high CRP values without cause in thorough ENT examination. OBJECTIVE: To describe the clinical manifestation of head and neck giant cell arteritis and to derive a diagnostic pathway covering atypical cases. METHOD: Single-center, retrospective analysis of cases with GCA in the head and neck region (HN-GCA) (2002-2012) to describe the clinical presentation and to derive a diagnostic pathway covering manifestations presenting to an ENT department...
April 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28439995/scleromyxoedema-in-a-dog
#10
Aurore F Laprais, Petra Bizikova, Erin W Lashnits, Alison Tucker, Keith E Linder
BACKGROUND: In humans, scleromyxoedema is a chronic progressive skin condition traditionally characterized by deposits of mucin, increased number of fibroblasts and fibrosis in the skin, and by systemic disease. Thyroid disease is typically absent. A monoclonal gammopathy is usually present, as are other comorbidities. Descriptions of scleromyxoedema in the veterinary literature are limited to a single feline case. One dog, previously reported as having papular mucinosis, exhibited features that matched the more current diagnostic criteria of scleromyxoedema...
April 24, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#11
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28439243/relationships-between-behavioural-addictions-and-psychiatric-disorders-what-is-known-and-what-is-yet-to-be-learned
#12
Vladan Starcevic, Yasser Khazaal
This article provides a narrative review of the relationships between several behavioural addictions [pathological gambling, problematic Internet use (PIU), problematic online gaming, compulsive sexual behaviour disorder, compulsive buying, and exercise addiction] and psychiatric disorders. Associations between most behavioural addictions and depressive and anxiety disorders are strong and seem relatively non-specific. Strong links with substance use disorders may support the notion that some people are more prone to addictive behaviours, regardless of whether these involve substances or problematic activities...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28438477/apnea-in-the-term-infant
#13
REVIEW
Mary Elaine Patrinos, Richard J Martin
Whereas apnea of prematurity has been well defined and its pathophysiology extensively studied, apnea in the term infant remains a greater challenge. Unfortunately, clear diagnostic criteria are lacking and pathogenesis and management vary widely. In this review we have arbitrarily organized the discussion chronologically into earlier and later postnatal periods. In the first days of life, presumed apnea may reflect physiologic events such as positional or feeding etiologies, or may be a manifestation of serious pathophysiology, such as a seizure disorder...
April 21, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28438399/type-2-myocardial-infarction-due-to-supply-demand-mismatch
#14
REVIEW
Nino Mihatov, James L Januzzi, Hanna K Gaggin
The best-accepted definition of myocardial infarction (MI) is provided by statements from the Universal Definition of MI Global Task force. This article, now in its third iteration, defines MI as myocardial cell death due to prolonged myocardial ischemia. It further delineates an increasingly incident subclassification of MI known as type 2 MI (T2MI). T2MI identifies instances of myocardial necrosis in which an imbalance between myocardial oxygen supply and/or demand occurs for reasons other than atherosclerotic plaque disruption...
March 11, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28438394/gastric-foveolar-dysplasia-a-survey-of-reporting-habits-and-diagnostic-criteria
#15
Stefano Serra, Rola Ali, Adrian C Bateman, Kaushik Dasgupta, Vikram Deshpande, David K Driman, David Gibbons, Andrea Grin, Sara Hafezi-Bakhtiari, Kieran Sheahan, Amitabh Srivastava, Eva Szentgyorgyi, Rajkumar Vajpeyi, Shaun Walsh, Lai Mun Wang, Runjan Chetty
This study aimed to ascertain views, incidence of reporting and diagnostic criteria for gastric foveolar dysplasia. A questionnaire, a post-questionnaire discussion and microscopic assessment of selected cases was conducted by gastrointestinal pathologists to explore the above-stated aims. Fifty-four percent of respondents never or rarely diagnosed gastric foveolar-type dysplasia. The general consensus was that round nuclei, lack of nuclear stratification, presence of inflammation/damage and surface maturation favoured reactive change; while architectural abnormalities/complexity and nuclear enlargement mainly were used to separate low-grade from high-grade foveolar dysplasia...
April 21, 2017: Pathology
https://www.readbyqxmd.com/read/28438300/malignant-transformation-of-oral-lichen-planus-and-oral-lichenoid-lesions-a-meta-analysis-of-20095-patient-data
#16
REVIEW
Sana Maher Hasan Aghbari, Abdelrahman Ibrahim Abushouk, Attia Attia, Ahmed Elmaraezy, Amr Menshawy, Mohamed Shehata Ahmed, Basma Abdelaleem Elsaadany, Eman Magdy Ahmed
OBJECTIVES: For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: We searched Medline, Scopus, and Web of Knowledge for relevant observational studies...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28438197/anti-malarial-landscape-in-myanmar-results-from-a-nationally-representative-survey-among-community-health-workers-and-the-private-sector-outlets-in-2015-2016
#17
Si Thu Thein, Hnin Su Su Khin, Aung Thi
BACKGROUND: In 2015/2016, an ACTwatch outlet survey was implemented to assess the anti-malarial and malaria testing landscape in Myanmar across four domains (Eastern, Central, Coastal, Western regions). Indicators provide an important benchmark to guide Myanmar's new National Strategic Plan to eliminate malaria by 2030. METHODS: This was a cross-sectional survey, which employed stratified cluster-random sampling across four regions in Myanmar. A census of community health workers (CHWs) and private outlets with potential to distribute malaria testing and/or treatment was conducted...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438163/enhanced-status-of-inflammation-and-endothelial-activation-in-subjects-with-familial-hypercholesterolaemia-and-their-related-unaffected-family-members-a-case-control-study
#18
Thuhairah Rahman, Nur Suhana Hamzan, Atiqah Mokhsin, Radzi Rahmat, Zubin Othman Ibrahim, Rafezah Razali, Malathi Thevarajah, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) leads to premature coronary artery diseases (CAD) which pathophysiologically can be measured by inflammation, endothelial activation and oxidative stress status. However, the status of these biomarkers among related unaffected relatives of FH cases and whether FH is an independent predictor of these biomarkers have not been well established. Thus, this study aims to (1) compare the biomarkers of inflammation, endothelial activation and oxidative stress between patients with FH, their related unaffected relatives (RUC) and normolipaemic subjects (NC) (2)determine whether FH is an independent predictor of these biomarkers...
April 24, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28437513/prevalence-of-temporomandibular-disorders-in-the-northern-finland-birth-cohort-1966
#19
Päivi Jussila, Heikki Kiviahde, Ritva Näpänkangas, Jari Päkkilä, Paula Pesonen, Kirsi Sipilä, Pertti Pirttiniemi, Aune Raustia
AIMS: To investigate the prevalence of temporomandibular disorders (TMD) in the 46-year-old cohort subjects from the Northern Finland Birth Cohort 1966 (NFBC 1966). METHODS: Altogether, 1,962 subjects (1,050 women, 912 men) participated in a clinical medical and dental examination and responded to questionnaires in 2012 to 2013. The stomatognathic examination was performed according to a modified protocol of the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD)...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28437459/management-and-outcomes-of-severe-dengue-patients-presenting-with-sepsis-in-a-tropical-country
#20
Prapit Teparrukkul, Viriya Hantrakun, Nicholas P J Day, T Eoin West, Direk Limmathurotsakul
BACKGROUND: Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management and outcomes of dengue patients presenting with sepsis in a prospective study of community-acquired sepsis in Thailand. METHODS: From June to December 2015, 874 adult patients (age≥18 years) with suspected or documented community-acquired infection, with ≥3 diagnostic criteria for sepsis according to the Surviving Sepsis Campaign 2012, and within 24 hours of admission were evaluated...
2017: PloS One
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