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https://www.readbyqxmd.com/read/28550611/-18-f-fluorodeoxyglucose-positron-emission-tomography-in-the-diagnosis-of-malignancy-in-patients-with-paraneoplastic-neurological-syndrome-a-systematic-review-and-meta-analysis
#1
REVIEW
Ana María García Vicente, Roberto C Delgado-Bolton, Mariano Amo-Salas, Jesús López-Fidalgo, Ana Paula Caresia Aróztegui, José Ramón García Garzón, Javier Orcajo Rincón, María José García Velloso, María de Arcocha Torres, Soledad Alvárez Ruíz
PURPOSE: The detection of occult cancer in patients suspected of having a paraneoplastic neurological syndrome (PNS) poses a diagnostic challenge. The aim of our study was to perform a systematic review and meta-analysis to assess the diagnostic performance of FDG PET for the detection of occult malignant disease responsible for PNS. METHODS: A systematic review of the literature (MEDLINE, EMBASE, Cochrane, and DARE) was undertaken to identify studies published in any language...
May 27, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28550609/validation-of-the-taps-1-a-four-item-screening-tool-to-identify-unhealthy-substance-use-in-primary-care
#2
Jan Gryczynski, Jennifer McNeely, Li-Tzy Wu, Geetha A Subramaniam, Dace S Svikis, Lauretta A Cathers, Gaurav Sharma, Jacqueline King, Eve Jelstrom, Courtney D Nordeck, Anjalee Sharma, Shannon G Mitchell, Kevin E O'Grady, Robert P Schwartz
BACKGROUND: The Tobacco, Alcohol, Prescription Medication, and Other Substance use (TAPS) tool is a combined two-part screening and brief assessment developed for adult primary care patients. The tool's first-stage screening component (TAPS-1) consists of four items asking about past 12-month use for four substance categories, with response options of never, less than monthly, monthly, weekly, and daily or almost daily. OBJECTIVE: To validate the TAPS-1 in primary care patients...
May 26, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28550499/systematic-review-of-fmri-compatible-devices-design-and-testing-criteria
#3
REVIEW
V Hartwig, N Carbonaro, A Tognetti, N Vanello
Functional Magnetic Resonance Imaging (fMRI) is at present one of the most used methodologies for functional brain exploration, both in clinical and research settings. fMRI can noninvasively measure neural activity by using specific experimental paradigms. Often, these paradigms require the stimulation of the subject to perform sensorimotor tasks: in the past, the stimuli have been administered manually for investigating fundamental aspects of tactile perception and somatosensory processing. Nowadays, the use of mechatronic devices to stimulate the subject during fMRI studies is growing, also to assure reproducibility, control, and monitoring of task performances...
May 26, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28550399/addition-of-second-line-steroid-sparing-immunosuppressants-like-mycophenolate-mofetil-improves-outcome-of-immunoglobulin-g4-related-disease-igg4-rd-a-series-from-a-tertiary-care-teaching-hospital-in-south-india
#4
Nikhil Gupta, John Mathew, Hindhumathi Mohan, Sudipta Dhar Chowdhury, Reuben Thomas Kurien, D J Christopher, Balamugesh Thangakunam, Mathew Alexander, Ajith Sivadasan, V Tamilarasi, Anna T Valson, Mahasampath Gowri, Jayakanthan Kabeerdoss, Debashish Danda
IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disease. This disease may be associated with elevated serum and tissue IgG4 levels. Early treatment prevents fibrosis and organ damage. We retrospectively studied the clinicopathologic correlation and outcome of treatment in IgG4-RD. This single-center retrospective study was done using electronic records of patients subjected to assay of serum IgG4 levels in our laboratory by nephelometry. There were 473 patients with suspected IgG4-RD. Of them, 41 patients fulfilled comprehensive diagnostic criteria for IgG4-RD and 432 had diseases other than IgG4-RD...
May 26, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28550351/diagnostic-and-treatment-guidelines-for-thrombotic-thrombocytopenic-purpura-ttp-2017-in-japan
#5
Masanori Matsumoto, Yoshihiro Fujimura, Hideo Wada, Koichi Kokame, Yoshitaka Miyakawa, Yasunori Ueda, Satoshi Higasa, Takanori Moriki, Hideo Yagi, Toshiyuki Miyata, Mitsuru Murata
Thrombotic thrombocytopenic purpura (TTP) can rapidly progress into a life-threatening condition, thus the importance of appropriate diagnosis and treatment cannot be overstated. Until recently, TTP has mainly been diagnosed by clinical findings such as thrombocytopenia and non-immune hemolytic anemia. In addition to these clinical findings, however, reduced activity of a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) below 10% has been accepted internationally as a diagnostic criterion for TTP...
May 26, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28550344/diagnosing-mild-cognitive-impairment-in-parkinson-s-disease-which-tests-perform-best-in-the-italian-population
#6
Angela Federico, Michela Trentin, Giampietro Zanette, Daniela Mapelli, Alessandro Picelli, Nicola Smania, Michele Tinazzi, Stefano Tamburin
Mild cognitive impairment (MCI) is common in patients with Parkinson's disease (PD) and should be recognized early because it represents a predictor of PD-related dementia and worse disease course. Diagnostic criteria for PD-related MCI (PD-MCI) have recently been defined by a Movement Disorders Society (MDS) task force. The present study explored which neuropsychological tests perform best for a level II (i.e., comprehensive neuropsychological assessment) diagnosis of PD-MCI according to the MDS task force criteria in Italian-speaking PD patients...
May 26, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28550069/incidence-and-prevalence-of-nmosd-in-australia-and-new-zealand
#7
Wajih Bukhari, Kerri M Prain, Patrick Waters, Mark Woodhall, Cullen M O'Gorman, Laura Clarke, Roger A Silvestrini, Christine S Bundell, David Abernethy, Sandeep Bhuta, Stefan Blum, Mike Boggild, Karyn Boundy, Bruce J Brew, Matthew Brown, Wallace J Brownlee, Helmut Butzkueven, William M Carroll, Celia Chen, Alan Coulthard, Russell C Dale, Chandi Das, Keith Dear, Marzena J Fabis-Pedrini, David Fulcher, David Gillis, Simon Hawke, Robert Heard, Andrew P D Henderson, Saman Heshmat, Suzanne Hodgkinson, Sofia Jimenez-Sanchez, Trevor Killpatrick, John King, Christopher Kneebone, Andrew J Kornberg, Jeannette Lechner-Scott, Ming-Wei Lin, Christpher Lynch, Richard Macdonell, Deborah F Mason, Pamela A McCombe, Michael P Pender, Jennifer A Pereira, John D Pollard, Stephen W Reddel, Cameron Shaw, Judith Spies, James Stankovich, Ian Sutton, Steve Vucic, Michael Walsh, Richard C Wong, Eppie M Yiu, Michael H Barnett, Allan G Kermode, Mark P Marriott, John D E Parratt, Mark Slee, Bruce V Taylor, Ernest Willoughby, Robert J Wilson, Angela Vincent, Simon A Broadley
OBJECTIVES: We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry. BACKGROUND: NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established. METHODS: Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD...
May 26, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28549946/potential-metabolomic-biomarkers-for-reliable-diagnosis-of-behcet-s-disease-using-gas-chromatography-with-time-of-flight-mass-spectrometry
#8
Joong Kyong Ahn, Jungyeon Kim, Jiwon Hwang, Juhwan Song, Kyoung Heon Kim, Hoon-Suk Cha
OBJECTIVES: Although many diagnostic criteria of Behcet's disease (BD) have been developed and revised by experts, diagnosing BD is still complicated and challenging. No metabolomic studies on serum have been attempted to improve the diagnosis and to identify potential biomarkers of BD. The purposes of this study were to investigate distinctive metabolic changes in serum samples of BD patients and to identify metabolic candidate biomarkers for reliable diagnosis of BD using the metabolomics platform...
May 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28549927/molecular-classification-of-adult-diffuse-gliomas-conflicting-idh1-idh2-atrx-and-1p-19q-results
#9
Leomar Y Ballester, Jason T Huse, Guilin Tang, Gregory N Fuller
Until recently, the diagnosis of brain tumors was primarily based on microscopic examination of hematoxylin and eosin (H&E) stained tissue sections. The updated World Health Organization (WHO) classification of tumours of the central nervous system (CNS) incorporates genetic alterations into the classification system, with the goal of creating more homogenous disease categories with greater prognostic value. Hence, under the new classification system the diagnosis of diffuse gliomas incorporates the evaluation of mutations in the IDH1 and IDH2 genes and simultaneous deletion of chromosomes 1p and 19...
May 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28549896/concordance-among-methods-of-nutritional-assessment-in-patients-included-on-the-waiting-list-for-liver-transplantation
#10
María Teresa García-Rodríguez, Beatriz López-Calviño, María Del Carmen Piñón-Villar, Alejandra Otero-Ferreiro, Francisco Suárez-López, Manuel Gómez-Gutiérrez, Sonia Pértega-Díaz, María Teresa Seoane-Pillado, Salvador Pita-Fernández
BACKGROUND: The aim of the present study was to determine the extent of malnutrition in patients waiting for a liver transplant. The agreement among the methods of nutritional assessment and their diagnostic validity were evaluated. METHODS: Patients on the waiting list for liver transplantation (n = 110) were studied. The variables were: body mass index, analytical parameters, liver disease etiology, and complications. Liver dysfunction was evaluated using the Child-Pugh Scale...
May 23, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28549330/impact-of-post-traumatic-stress-disorder-on-oral-health
#11
Ana Cristina de Oliveira Solis, Álvaro Cabral Araújo, Felipe Corchs, Marcio Bernik, Érica Panzani Duran, Cláudio Silva, Francisco Lotufo-Neto
BACKGROUND: The stress experienced as an intense and traumatic event can increase the odds of orofacial pain, affect the biomechanics of masticatory system and compromise the periodontal health. This study was conducted to investigate the impact of post-traumatic stress disorder (PTSD) on oral health. METHODS: A case-control study with a convenience sample was designed. Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing, and plaque were recorded at 6 sites per tooth...
May 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28549119/systematic-review-of-cost-effectiveness-of-myocardial-perfusion-scintigraphy-in-patients-with-ischaemic-heart-disease-a-report-from-the-cardiovascular-committee-of-the-european-association-of-nuclear-medicine-endorsed-by-the-european-association-of-cardiovascular
#12
Elin Trägårdh, Siok Swan Tan, Jan Bucerius, Alessia Gimelli, Oliver Gaemperli, Oliver Lindner, Denis Agostini, Christopher Übleis, Roberto Sciagrà, Riemer H Slart, S Richard Underwood, Fabien Hyafil, Marcus Hacker, Hein J Verberne
Coronary artery disease (CAD) is a major cause of death and disability. Several diagnostic tests, such as myocardial perfusion scintigraphy (MPS), are accurate for the detection of CAD, as well as having prognostic value for the prediction of cardiovascular events. Nevertheless, the diagnostic and prognostic value of these tests should be cost-effective and should lead to improved clinical outcome. We have reviewed the literature on the cost-effectiveness of MPS in different circumstances: (i) the diagnosis and management of CAD; (ii) comparison with exercise electrocardiography (ECG) and other imaging tests; (iii) as gatekeeper to invasive coronary angiography (ICA), (iv) the impact of appropriate use criteria; (v) acute chest pain, and (vi) screening of asymptomatic patients with type-2 diabetes...
May 26, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28549063/food-addiction-and-obesity-unnecessary-medicalization-of-hedonic-overeating
#13
REVIEW
Graham Finlayson
The concept of addiction is loaded with connotations and is often used for its political as much as its medical utility. The scientific case for 'food addiction' as a clinical phenotype currently rests on its association with generic diagnostic criteria for substance-related disorders being applied to everyday foods and eating-related problems. This has fused the concept of obesity with addiction regardless of whether it fits the definition. The hedonic, or reward, system can account for the ingestion of foods and drugs, confirming that they share neural substrates that differentiate liking and wanting...
May 26, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28548676/the-diagnosis-and-management-of-chronic-migraine-in-primary-care
#14
Werner J Becker
BACKGROUND: Chronic migraine is common, affecting approximately 1% of the general population, and causes significant disability. OBJECTIVE: To summarize optimal involvement of primary care physicians in chronic migraine care, and to provide algorithms to assist them in the diagnosis and management of patients with chronic migraine. METHODS: An analysis of diagnostic and treatment needs in chronic migraine, based on a synthesis of the medical literature and clinical experience...
May 26, 2017: Headache
https://www.readbyqxmd.com/read/28548545/mild-chronic-obstructive-pulmonary-disease-why-spirometry-is-not-sufficient
#15
Amany F Elbehairy, Grace Parraga, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly mild airway obstruction poses a challenge in clinical practice as spirometry can obscure extensive heterogeneous pathophysiological impairment...
May 26, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28548190/-clinical-features-of-major-depressive-disorders-treated-in-secondary-health-care-facilities-in-chile
#16
Lilian Salvo, Sandra Saldivia, Carlos Parra, Román Rodríguez, Manuel Cifuentes, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
BACKGROUND: Depression is considered the second leading cause of disability worldwide. AIM: To describe the clinical characteristics and the evolution of major depressive disorder (MDD) in secondary care. To evaluate the association between socio-demographic and clinic variables with the first or recurrent major depressive events (MDE). MATERIAL AND METHODS: Clinical features, treatment, remission and duration of MDE were evaluated during a follow up lasting 12 months in 112 participants aged 44 ± 15 years (79% women)...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28547881/prevalence-and-clinical-correlates-of-insomnia-in-adults-with-attention-deficit-hyperactivity-disorder
#17
E J Brevik, A J Lundervold, A Halmøy, M-B Posserud, J T Instanes, B Bjorvatn, J Haavik
OBJECTIVE: To investigate the prevalence of insomnia in adults with Attention-deficit hyperactivity disorder (ADHD) and its association with clinical subtypes, current ADHD symptoms, and stimulant treatment. METHOD: We obtained diagnostic information, symptom rating scales and treatment history from clinically ascertained adult ADHD patients diagnosed according to DSM-IV criteria (n = 268, mean age 38.1 years) and randomly selected population controls (n = 202, mean age 36...
May 26, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28547674/diagnostic-accuracy-of-various-modalities-relative-to-open-bone-biopsy-for-detection-of-long-bone-posttraumatic-osteomyelitis
#18
Vivek Chadayammuri, Benoit Herbert, Jiandong Hao, Andreas Mavrogenis, Juan C Quispe, Ji Wan Kim, Heather Young, Mark Hake, Cyril Mauffrey
BACKGROUND: Long bone posttraumatic osteomyelitis (PTOM) is a relatively common complication following surgical fixation of open fractures. There is a lacking consensus on ideal strategies for diagnostic evaluation of long bone PTOM. While open bone biopsy and culture is considered the 'gold diagnostic standard,' its cost and invasiveness are often prohibitive and have prompted the search for alternate diagnostic methods. OBJECTIVE: To evaluate the sensitivity and specificity of various diagnostic modalities relative to open bone biopsy and culture for the detection of long bone PTOM...
May 25, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28546530/quotidian-high-spiking-fevers-in-adult-still-s-disease
#19
Jessica L Feuerstein, David E Klein, Mark A Mikhitarian, Anuj Mehta
BACKGROUND Adult Still's disease (ASD) is a rare systemic inflammatory condition, which commonly presents with the triad of quotidian fevers, rash, and non-specific rheumatologic symptoms such as myalgia and arthralgia. The etiology and pathogenesis are poorly understood and both the clinical presentation and laboratory data are typically nonspecific. As such, the presentation is often confused with infection, other autoimmune processes, and malignancy. CASE REPORT We present a case of a 29-year-old Hispanic female who presented with fever, sore throat, myalgia, and shortness of breath...
May 26, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28546336/the-value-of-18-f-fdg-pet-ct-in-diagnosis-and-during-follow-up-in-273-patients-with-chronic-q-fever
#20
Ilse Kouijzer, Linda Kampschreur, Peter Wever, Corneline Hoekstra, Marjo van Kasteren, Monique de Jager-Leclercq, Marrigje Nabuurs-Franssen, Marjolijn Wegdam-Blans, Heidi Ammerlaan, Jacqueline Buijs, Lioe-Fee de Geus-Oei, Wim Oyen, Chantal Bleeker-Rovers
In 1-5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in chronic Q fever at diagnosis and during follow-up. Methods: All Dutch adult patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015 when at least one (18)F-FDG-PET/CT was performed...
May 25, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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