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https://www.readbyqxmd.com/read/28633067/microbial-electrosynthesis-of-butyrate-from-carbon-dioxide-production-and-extraction
#1
Pau Batlle-Vilanova, Ramon Ganigué, Sara Ramió-Pujol, Lluís Bañeras, Gerard Jiménez, Manuela Hidalgo, M Dolors Balaguer, Jesús Colprim, Sebastià Puig
To date acetate is the main product of microbial electrosynthesis (MES) from carbon dioxide (CO2). In this work a tubular bioelectrochemical system was used to carry out MES and enhance butyrate production over the other organic products. Batch tests were performed at a fixed cathode potential of -0.8V vs SHE. The reproducibility of the results according to previous experiments was validated in a preliminary test. According to the literature butyrate production could take place by chain elongation reactions at low pH and high hydrogen partial pressure (pH2)...
June 15, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28632745/evaluating-patterns-and-drivers-of-spatial-change-in-the-recreational-guided-fishing-sector-in-alaska
#2
Maggie N Chan, Anne H Beaudreau, Philip A Loring
Understanding the impacts of recreational fishing on habitats and species, as well as the social and ecological importance of place to anglers, requires information on the spatial distribution of fishing activities. This study documented long-term changes in core fishing areas of a major recreational fishery in Alaska and identified biological, regulatory, social, and economic drivers of spatial fishing patterns by charter operators. Using participatory mapping and in-person interviews, we characterized the spatial footprint of 46 charter operators in the communities of Sitka and Homer since the 1990s...
2017: PloS One
https://www.readbyqxmd.com/read/28632014/coaching-the-coach-a-program-for-development-of-faculty-portfolio-coaches
#3
Jack Kopechek, Cheryl Bardales, A Todd Lash, Curtis Walker, Sheryl Pfeil, Cynthia H Ledford
PROBLEM: Faculty coaching is recognized as an essential element for effective use of portfolios in undergraduate medical education, yet best practices for training these coaches are uncertain. INTERVENTION: New portfolio coaches participated in a multifaceted training program that included orienting modules, a 7.5-hr training workshop featuring analysis of reflective writing, an Observed Structured Teaching Exercise (OSTE), and subsequent longitudinal coaches' meetings for timely task training...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28632010/designing-a-national-longitudinal-faculty-development-curriculum-focused-on-educational-scholarship-process-outcomes-and-lessons-learned
#4
Latha Chandran, Maryellen E Gusic, J Lindsey Lane, Constance D Baldwin
PROBLEM: Clinical educators at U.S. academic health centers are frequently disadvantaged in the academic promotion system, lacking needed faculty development, mentoring, and networking support. INTERVENTION: In 2006, we implemented the national Educational Scholars Program to offer faculty development in educational scholarship for early career educators in pediatrics. We aimed to provide them with skills, experience, and initial success in educational scholarship and dissemination...
March 2, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28630353/evaluation-of-a-proposal-for-reliable-low-cost-grid-power-with-100-wind-water-and-solar
#5
Christopher T M Clack, Staffan A Qvist, Jay Apt, Morgan Bazilian, Adam R Brandt, Ken Caldeira, Steven J Davis, Victor Diakov, Mark A Handschy, Paul D H Hines, Paulina Jaramillo, Daniel M Kammen, Jane C S Long, M Granger Morgan, Adam Reed, Varun Sivaram, James Sweeney, George R Tynan, David G Victor, John P Weyant, Jay F Whitacre
A number of analyses, meta-analyses, and assessments, including those performed by the Intergovernmental Panel on Climate Change, the National Oceanic and Atmospheric Administration, the National Renewable Energy Laboratory, and the International Energy Agency, have concluded that deployment of a diverse portfolio of clean energy technologies makes a transition to a low-carbon-emission energy system both more feasible and less costly than other pathways. In contrast, Jacobson et al. [Jacobson MZ, Delucchi MA, Cameron MA, Frew BA (2015) Proc Natl Acad Sci USA 112(49):15060-15065] argue that it is feasible to provide "low-cost solutions to the grid reliability problem with 100% penetration of WWS [wind, water and solar power] across all energy sectors in the continental United States between 2050 and 2055", with only electricity and hydrogen as energy carriers...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629934/recent-advances-in-leishmania-reverse-genetics-manipulating-a-manipulative-parasite
#6
REVIEW
Samuel M Duncan, Nathaniel G Jones, Jeremy C Mottram
In this review we describe the expanding repertoire of molecular tools with which to study gene function in Leishmania. Specifically we review the tools available for studying functions of essential genes, such as plasmid shuffle and DiCre, as well as the rapidly expanding portfolio of available CRISPR/Cas9 approaches for large scale gene knockout and endogenous tagging. We include detail on approaches that allow the direct manipulation of RNA using RNAi and protein levels via Tet or DiCre induced overexpression and destabilization domain mediated degradation...
June 16, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28625861/the-policy-effects-of-feed-in-tariff-and-renewable-portfolio-standard-a-case-study-of-china-s-waste-incineration-power-industry
#7
Zhao Xin-Gang, Zhang Yu-Zhuo, Ren Ling-Zhi, Zuo Yi, Wu Zhi-Gong
Among the regulatory policies, feed-in tariffs (FIT) and renewable portfolio standards (RPS) are the most popular to promote the development of renewable energy power industry. They can significantly contribute to the expansion of domestic industrial activities in terms of sustainable energy. This paper uses system dynamics (SD) to establish models of long-term development of China's waste incineration power industry under FIT and RPS schemes, and provides a case study by using scenario analysis method. The model, on the one hand, not only clearly shows the complex logical relationship between the factors but also assesses policy effects of the two policy tools in the development of the industry...
June 15, 2017: Waste Management
https://www.readbyqxmd.com/read/28624601/the-manchester-fly-facility-implementing-an-objective-driven-long-term-science-communication-initiative
#8
REVIEW
Sanjai Patel, Andreas Prokop
Science communication is increasingly important for scientists, although research, teaching and administration activities tend to eat up our time already, and budgets for science communication are usually low. It appears impossible to combine all these tasks and, in addition, to develop engagement activities to a quality and impact that would make the efforts worth their while. Here we argue that these challenges are easier addressed when centering science communication initiatives on a long-term vision with a view to eventually forming outreach networks where the load can be shared whilst being driven to higher momentum...
June 15, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28611423/catalytic-transformation-of-functionalized-carboxylic-acids-using-multifunctional-rhenium-complexes
#9
Masayuki Naruto, Santosh Agrawal, Katsuaki Toda, Susumu Saito
Carboxylic acids (CAs) are one of the most ubiquitous and important chemical feedstocks available from biorenewable resources, CO2, and the petrochemical industry. Unfortunately, chemoselective catalytic transformations of CH n CO2H (n = 1-3) groups into other functionalities remain a significant challenge. Herein, we report rhenium(V) complexes as extremely effective precatalysts for this purpose. Compared to previously reported heterogeneous and homogeneous catalysts derived from high- or low-valent metals, the present method involves a α-C-H bond functionalization, a hydrogenation, and a hydrogenolysis, which affords functionalized alcohols with a wide substrate scope and high chemoselectivity under relatively mild reaction conditions...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611186/success-failure-and-transparency-in-biomarker-based-drug-development-a-case-study-of-cholesteryl-ester-transfer-protein-inhibitors
#10
Spencer Phillips Hey, Jessica M Franklin, Jerry Avorn, Aaron S Kesselheim
BACKGROUND: Although biomarkers are used as surrogate measures for drug targeting and approval and are generally based on plausible biological hypotheses, some are found to not correlate well with clinical outcomes. Over-reliance on inadequately validated biomarkers in drug development can lead to harm to trial subjects and patients and to research waste. To shed greater light on the process and ethics of biomarker-based drug development, we conducted a systematic portfolio analysis of cholesterol ester transfer protein inhibitors, a drug class designed to improve lipid profiles and prevent cardiovascular events...
June 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28609349/-novel-approach-for-maximizing-follow-up-in-cosmetic-surgery-clinical-trials-the-ideal-implant-core-trial-experience
#11
Melissa A Mueller, Larry S Nichter, Robert S Hamas
BACKGROUND-: High follow-up rates are critical for robust research with minimal bias and particularly important for breast implant Core Studies seeking FDA approval. The Core Study for IDEAL IMPLANT, the most recently FDA-approved breast implant, utilized a novel incentive payment model to achieve higher follow-up rates than in previous breast implant trials. METHODS-: At enrollment, $3,500 was deposited into an independent, irrevocable trust for each of the 502 subjects and invested in a diversified portfolio...
June 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28606596/mini-review-recombinant-production-of-tailored-bio-pharmaceuticals-in-different-bacillus-strains-and-future-perspectives
#12
REVIEW
Antonia Lakowitz, Thibault Godard, Rebekka Biedendieck, Rainer Krull
Bio-pharmaceuticals like antibodies, hormones and growth factors represent about one-fifth of commercial pharmaceuticals. Host candidates of growing interest for recombinant production of these proteins are strains of the genus Bacillus, long being established for biotechnological production of homologous and heterologous proteins. Bacillus strains benefit from development of efficient expression systems in the last decades and emerge as major industrial workhorses for recombinant proteins due to easy cultivation, non-pathogenicity and their ability to secrete recombinant proteins directly into extracellular medium allowing cost-effective downstream processing...
June 9, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28602358/institutional-racism-in-public-health-contracting-findings-of-a-nationwide-survey-from-new-zealand
#13
H Came, C Doole, B McKenna, T McCreanor
Public institutions within New Zealand have long been accused of mono-culturalism and institutional racism. This study sought to identify inconsistencies and bias by comparing government funded contracting processes for Māori public health providers (n = 60) with those of generic providers (n = 90). Qualitative and quantitative data were collected (November 2014-May 2015), through a nationwide telephone survey of public health providers, achieving a 75% response rate. Descriptive statistical analyses were applied to quantitative responses and an inductive approach was taken to analyse data from open-ended responses in the survey domains of relationships with portfolio contract managers, contracting and funding...
June 3, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28601913/the-effects-of-a-non-cognitive-versus-cognitive-admission-procedure-within-cohorts-in-one-medical-school
#14
Marieke de Visser, Cornelia Fluit, Janke Cohen-Schotanus, Roland Laan
In medical school selection, non-cognitive performance in particular correlates with performance in clinical practice. It is arguable, therefore, that selection should focus on non-cognitive aspects despite the predictive value of prior cognitive performance for early medical school performance. The aim of this study at Radboud University Medical Center, the Netherlands, is to determine the effects of admitting students through an autonomous non-cognitive procedure on early medical school performance. We compared their performance to the performance of students selected through an autonomous cognitive selection procedure, enrolling in the Bachelor's curriculum simultaneously...
June 10, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/28600267/a-peak-price-tracking-based-learning-system-for-portfolio-selection
#15
Zhao-Rong Lai, Dao-Qing Dai, Chuan-Xian Ren, Ke-Kun Huang
We propose a novel linear learning system based on the peak price tracking (PPT) strategy for portfolio selection (PS). Recently, the topic of tracking control attracts intensive attention and some novel models are proposed based on backstepping methods, such that the system output tracks a desired trajectory. The proposed system has a similar evolution with a transform function that aggressively tracks the increasing power of different assets. As a result, the better performing assets will receive more investment...
June 7, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28595659/uses-of-nutrient-profiling-to-address-public-health-needs-from-regulation-to-reformulation
#16
Adam Drewnowski
Nutrient profiling (NP) models rate the nutritional quality of individual foods, based on their nutrient composition. Their goal is to identify nutrient-rich foods, generally defined as those that contain more nutrients than calories and are low in fat, sugar and salt. NP models have provided the scientific basis for evaluating nutrition and health claims and regulating marketing and advertising to children. The food industry has used NP methods to reformulate product portfolios. To help define what we mean by healthy foods, NP models need to be based on published nutrition standards, mandated serving sizes and open-source nutrient composition databases...
June 9, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28588592/in-depth-genomic-and-transcriptomic-analysis-of-five-k-transporter-gene-families-in-soybean-confirm-their-differential-expression-for-nodulation
#17
Hafiz M Rehman, Muhammad A Nawaz, Zahid Hussain Shah, Ihsanullah Daur, Sadia Khatoon, Seung Hwan Yang, Gyuhwa Chung
Plants have evolved a sophisticated network of K(+) transport systems to regulate growth and development. Limited K(+) resources are now forcing us to investigate how plant demand can be satisfied. To answer this complex question, we must understand the genomic and transcriptomic portfolio of K(+) transporters in plants. Here, we have identified 70 putative K(+) transporter genes from soybean, including 29 HAK/KT/KUP genes, 16 genes encoding voltage-gated K(+) channels, 9 TPK/KCO genes, 4 HKT genes, and 12 KEA genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28588145/ecosystem-based-management-and-the-wealth-of-ecosystems
#18
Seong Do Yun, Barbara Hutniczak, Joshua K Abbott, Eli P Fenichel
We merge inclusive wealth theory with ecosystem-based management (EBM) to address two challenges in the science of sustainable management of ecosystems. First, we generalize natural capital theory to approximate realized shadow prices for multiple interacting natural capital stocks (species) making up an ecosystem. These prices enable ecosystem components to be better included in wealth-based sustainability measures. We show that ecosystems are best envisioned as portfolios of assets, where the portfolio's performance depends on the performance of the underlying assets influenced by their interactions...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28587626/evaluation-of-a-novel-antibody-to-define-histone-3-3-g34r-mutant-brain-tumours
#19
Farhana Haque, Pascale Varlet, Julien Puntonet, Lisa Storer, Aikaterini Bountali, Ruman Rahman, Jacques Grill, Angel M Carcaboso, Chris Jones, Robert Layfield, Richard G Grundy
Missense somatic mutations affecting histone H3.1 and H3.3 proteins are now accepted as the hallmark of paediatric diffuse intrinsic pontine gliomas (DIPG), non-brain stem paediatric high grade gliomas (pHGG) as well as a subset of adult glioblastoma multiforme (GBM). Different mutations give rise to one of three amino acid substitutions at two critical positions within the histone tails, K27M, G34R/V. Several studies have highlighted gene expression and epigenetic changes associated with histone H3 mutations; however their precise roles in tumourigenesis remain incompletely understood...
June 6, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28584866/the-prescription-talk-an-approach-to-teach-patient-physician-conversation-about-drug-prescription-to-medical-students
#20
Katarina Hauser, Armin Koerfer, Mathilde Niehaus, Christian Albus, Stefan Herzig, Jan Matthes
Background: Medication communication from physicians to patients often is poor, by this among others enhancing the risk of non-adherence. In this context, a neglect regarding the prescription talk has been complained. Aim of the project: In a newly developed elective medical students work on physician-patient conversations dealing with drug prescription. Essential aspects related to an effective and safe drug treatment are combined with steps of shared decision-making. Together with a tutor, students develop a (model) conversation guide that might be tailored according to individual needs and views...
2017: GMS Journal for Medical Education
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