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https://www.readbyqxmd.com/read/28333971/a-note-on-contracts-on-quadratic-variation
#1
Carl Lindberg
Given a Black stochastic volatility model for a future F, and a function g, we show that the price of [Formula: see text] can be represented by portfolios of put and call options. This generalizes the classical representation result for the variance swap. Further, in a local volatility model, we give an example based on Dupire's formula which shows how the theorem can be used to design variance related contracts with desirable characteristics.
2017: PloS One
https://www.readbyqxmd.com/read/28331960/synthesis-gas-biorefinery
#2
N Dahmen, E Henrich, T Henrich
Synthesis gas or syngas is an intermediate, which can be produced by gasification from a variety of carbonaceous feedstocks including biomass. Carbon monoxide and hydrogen, the main constituents of syngas, can be subjected to a broad range of chemical and microbial synthesis processes, leading to gaseous and liquid hydrocarbon fuels as well as to platform and fine chemicals. Gasification of solid biomass differs from coal gasification by chemical composition, heating value, ash behavior, and other technical and biomass related issues...
March 23, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28329179/research-on-skin-cancer-related-behaviors-and-outcomes-in-the-nih-grant-portfolio-2000-2014-skin-cancer-intervention-across-the-cancer-control-continuum-sci-3c
#3
Frank M Perna, Laura A Dwyer, Gina Tesauro, Jennifer M Taber, Wynne E Norton, Anne M Hartman, Alan C Geller
Importance: The Surgeon General's Call to Action to Prevent Skin Cancer broadly identified research gaps, but specific objectives are needed to further behavioral intervention research. Objective: To review National Institute of Health (NIH) grants targeting skin cancer-related behaviors and relevant outcomes. Design, Setting, and Participants: A portfolio analysis of the title, abstract, specific aims, and research plans of identified grant applications from 2000 to 2014 targeting skin cancer-related behaviors or testing behavioral intervention effects on cancer-relevant outcomes along the cancer continuum...
March 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28326126/scenarios-in-tropical-forest-degradation-carbon-stock-trajectories-for-redd
#4
REVIEW
Rafael B de Andrade, Jennifer K Balch, Amoreena L Parsons, Dolors Armenteras, Rosa Maria Roman-Cuesta, Janette Bulkan
BACKGROUND: Human-caused disturbance to tropical rainforests-such as logging and fire-causes substantial losses of carbon stocks. This is a critical issue to be addressed in the context of policy discussions to implement REDD+. This work reviews current scientific knowledge about the temporal dynamics of degradation-induced carbon emissions to describe common patterns of emissions from logging and fire across tropical forest regions. Using best available information, we: (i) develop short-term emissions factors (per area) for logging and fire degradation scenarios in tropical forests; and (ii) describe the temporal pattern of degradation emissions and recovery trajectory post logging and fire disturbance...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28315665/physician-scientists-in-obstetrics-and-gynecology-predictors-of-success-in-obtaining-independent-research-funding
#5
Ijeoma Okeigwe, Cynthia Wang, Joseph A Politch, Linda J Heffner, Wendy Kuohung
BACKGROUND: Obstetrics and gynecology departments receive the smallest amount of National Institutes of Health (NIH) research funding and have significantly lower application success rates compared to pediatric, internal medicine, and surgery departments. The development of mentored early career development training grants (K awards) has been one strategy implemented by the NIH to help aspiring physician-scientists establish independent research careers. OBJECTIVE: The purpose of this study is to describe the cohort of ob/gyn physician-scientists who were K08, K12, and K23 recipients from 1988-2015 and to identify predictors of success in obtaining independent federal funding, as defined by acquisition of an R01, R21, R34, U01, U54, P01, or P50...
March 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28314841/academic-cancer-center-phase-i-program-development
#6
Arthur E Frankel, Keith T Flaherty, George J Weiner, Robert Chen, Nilofer S Azad, Michael J Pishvaian, John A Thompson, Matthew H Taylor, Daruka Mahadevan, A Craig Lockhart, Ulka N Vaishampayan, Jordan D Berlin, David C Smith, John Sarantopoulos, Matthew Riese, Mansoor N Saleh, Chul Ahn, Eugene P Frenkel
Multiple factors critical to the effectiveness of academic phase I cancer programs were assessed among 16 academic centers in the U.S. Successful cancer centers were defined as having broad phase I and I/II clinical trial portfolios, multiple investigator-initiated studies, and correlative science. The most significant elements were institutional philanthropic support, experienced clinical research managers, robust institutional basic research, institutional administrative efforts to reduce bureaucratic regulatory delays, phase I navigators to inform patients and physicians of new studies, and a large cancer center patient base...
March 17, 2017: Oncologist
https://www.readbyqxmd.com/read/28314088/engaging-with-comparative-risk-appraisals-public-views-on-policy-priorities-for-environmental-risk-governance
#7
Sophie A Rocks, Iljana Schubert, Emma Soane, Edgar Black, Rachel Muckle, Judith Petts, George Prpich, Simon J Pollard
Communicating the rationale for allocating resources to manage policy priorities and their risks is challenging. Here, we demonstrate that environmental risks have diverse attributes and locales in their effects that may drive disproportionate responses among citizens. When 2,065 survey participants deployed summary information and their own understanding to assess 12 policy-level environmental risks singularly, their assessment differed from a prior expert assessment. However, participants provided rankings similar to those of experts when these same 12 risks were considered as a group, allowing comparison between the different risks...
March 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28314064/analysis-of-patients-willingness-to-be-mobile-taking-into-account-individual-characteristics-and-two-exemplary-indications
#8
Jobst Augustin, Ines Schäfer, Matthias Augustin, Nicole Zander
BACKGROUND: With respect to health care planning, it is commonly assumed that patients consult the nearest physician. In reality, however, patients frequently accept great-er efforts/expenses than necessary to see a physician. The objective of the present study was to determine under which circumstances patients were willing to accept additional efforts/expenses, and which role sociodemographic and clinical characteristics play in this regard. METHODS: Data collection was carried out in the context of a multicenter cross-sectional study among office-based and hospital-affiliated (University Medical Center Hamburg-Eppendorf) dermatologists...
March 17, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28300987/the-rio-de-janeiro-municipality-s-services-portfolio-and-health-actions-in-primary-care-in-brazil
#9
Bianca Alves Salazar, Mônica Rodrigues Campos, Vera Lucia Luiza
This study aimed to identify the provision of actions and procedures by family health teams (FHSt), based on Rio de Janeiro Municipality's (MRJ) Health Services Portfolio (HSP) and the main factors associated with this provision, in the different population strata. Data from the National Program for Improving Access and Quality of Primary Healthcare were used and implemented at the national level into 17,202 FHSts from June to September 2012. Outcome variables were "FHSt belonging to MRJ" and "FHSt providing all nine CS-MRJ procedures"...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28300986/primary-health-care-quality-in-rocinha-rio-de-janeiro-brazil-from-the-perspective-of-children-caregivers-and-adult-users
#10
Luiz Felipe Pinto, Erno Harzheim, Lisiane Hauser, Otávio Pereira D'Avila, Marcelo Rodrigues Gonçalves, Paula Travassos, Renan Pessanha
This paper aims to evaluate the extent of PHC attributes, from the experience of users, both adults and children caregivers, comparing the area served by the health facilities of the district of Rocinha with other areas of health district 2.1 in the municipality of Rio de Janeiro. The measuring tool used to evaluate the quality of services provided was the Primary Care Assessment Tools. A cross-sectional study was conducted, with independent random samples and 802 interviewees. Results indicate a better performance for children care when compared to adult care...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28299806/an-audit-of-second-trimester-fetal-anomaly-scans-based-on-a-novel-image-scoring-method-in-the-southwest-region-of-the-netherlands
#11
Nicolette T C Ursem, Ingrid A Peters, Mieke N Kraan-van der Est, Jacqueline C I Y Reijerink-Verheij, Maarten F C M Knapen, Titia E Cohen-Overbeek
OBJECTIVES: Since 2007 the second-trimester fetal anomaly scan is offered to all pregnant women as part of the national prenatal screening program in the Netherlands. Dutch population-based screening programs generally have a well-described system to achieve quality assurance. Because of the absence of a uniform system to monitor the actual performance of the fetal anomaly scan in 2012, we developed a standardized image-scoring method. The aim of this study was to evaluate the scanning performance of all sonographers in the southwestern region of the Netherlands using this image-scoring method...
March 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28295166/engineering-oxidative-stress-defense-pathways-to-build-a-robust-lipid-production-platform-in-yarrowia-lipolytica
#12
Peng Xu, Kangjian Qiao, Gregory Stephanopoulos
Microbially-derived lipids have recently attracted renewed interests due to their broad applications in production of green diesels, cosmetic additives and oleochemicals. Metabolic engineering efforts have targeted a large portfolio of biosynthetic pathways to efficiently convert sugar to lipids in oleaginous yeast. In the engineered overproducing strains, endogenous cell metabolism typically generates harmful electrophilic molecules that compromise cell fitness and productivity. Lipids, particularly unsaturated fatty acids, are highly susceptible to oxygen radical attack and the resulting oxidative species are detrimental to cell metabolism and limit lipid productivity...
March 14, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28294320/nursing-clinical-practice-changes-to-improve-self-management-in-chronic-obstructive-pulmonary-disease
#13
J M Padilha, P A F Sousa, F M S Pereira
AIM: To propose nursing clinical practice changes to improve the development of patient self-management. BACKGROUND: Chronic obstructive pulmonary disease is one of the main causes of chronic morbidity, loss of quality of life and high mortality rates. INTRODUCTION: Control of the disease's progression, the preservation of autonomy in self-care and maintenance of quality of life are extremely challenging for patients to execute in their daily living...
March 13, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28291951/utilisation-of-an-electronic-portfolio-to-engage-rehabilitation-professionals-in-continuing-professional-development-results-of-a-provincial-survey
#14
Marie-Lyse Foucault, Brigitte Vachon, Aliki Thomas, Annie Rochette, Charles-Édouard Giguère
INTRODUCTION: ePortfolios are frequently used to support continuing professional development (CPD) of rehabilitation professionals. Though this tool is now widely implemented in many professions by regulatory organisations, very few studies have investigated the use and impact among rehabilitation professionals. Implementation of comprehensive ePortfolios that are centred on the needs of rehabilitation professionals requires documenting their level of use and perceived outcomes. OBJECTIVES: The objectives were to describe how occupational therapists use a mandatory ePortfolio that has been recently implemented by a regulatory organisation in Quebec (Canada) and the perceived outcomes of this requirement on continuing professional development and practice change...
March 14, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28290357/an-international-survey-of-mri-qualification-and-certification-frameworks-with-an-emphasis-on-identifying-elements-of-good-practice
#15
J Castillo, C J Caruana, P S Morgan, C Westbrook, A Mizzi
The purpose of the study was to survey MRI qualification and certification frameworks in the major English-speaking countries (Australia, New Zealand, US, Canada, UK, Ireland) with the aim of identifying elements of good practice. The intention is to incorporate these elements in a national framework that could be used in supporting an MRI specialist register. The study was conducted using document analysis of MRI qualification and certification documents from these states with data triangulated through a web-based questionnaire amongst an expert group of MRI radiographers (n = 59) from the same states...
February 2017: Radiography
https://www.readbyqxmd.com/read/28289014/addressing-the-crisis-of-gp-recruitment-and-retention-a-systematic-review
#16
Catherine Marchand, Stephen Peckham
BACKGROUND: The numbers of GPs and training places in general practice are declining, and retaining GPs in their practices is an increasing problem. AIM: To identify evidence on different approaches to retention and recruitment of GPs, such as intrinsic versus extrinsic motivational determinants. DESIGN AND SETTING: Synthesis of qualitative and quantitative research using seven electronic databases from 1990 onwards (Medline, Embase, Cochrane Library, Health Management Information Consortium [HMIC], Cumulative Index to Nursing and Allied Health Literature (Cinahl), PsycINFO, and the Turning Research Into Practice [TRIP] database)...
March 13, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28286781/generation-of-monoclonal-antibodies-against-immunoglobulin-proteins-of-the-domestic-ferret-mustela-putorius-furo
#17
Greg A Kirchenbaum, Ted M Ross
The domestic ferret (Mustela putorius furo) serves as an animal model for the study of several viruses that cause human disease, most notably influenza. Despite the importance of this animal model, characterization of the immune response by flow cytometry (FCM) is severely hampered due to the limited number of commercially available reagents. To begin to address this unmet need and to facilitate more in-depth study of ferret B cells including the identification of antibody-secreting cells, eight unique murine monoclonal antibodies (mAb) with specificity for ferret immunoglobulin (Ig) were generated using conventional B cell hybridoma technology...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28281437/systems-metabolic-engineering-of-escherichia-coli
#18
Kyeong Rok Choi, Jae Ho Shin, Jae Sung Cho, Dongsoo Yang, Sang Yup Lee
Systems metabolic engineering, which recently emerged as metabolic engineering integrated with systems biology, synthetic biology, and evolutionary engineering, allows engineering of microorganisms on a systemic level for the production of valuable chemicals far beyond its native capabilities. Here, we review the strategies for systems metabolic engineering and particularly its applications in Escherichia coli. First, we cover the various tools developed for genetic manipulation in E. coli to increase the production titers of desired chemicals...
March 2017: EcoSal Plus
https://www.readbyqxmd.com/read/28279838/modulation-of-sphingosine-1-phosphate-in-inflammatory-bowel-disease
#19
REVIEW
Laurent Peyrin-Biroulet, Ronald Christopher, Dominic Behan, Cheryl Lassen
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, involve an inappropriate immune reaction in the digestive tract, causing a variety of disabling symptoms. The advent of monoclonal antibodies (anti-tumor necrosis factor, anti-integrin, anti-interleukin -23) has revolutionized IBD management. Nevertheless, these agents, with potential for immunogenicity, are associated with high rates of response loss and disease relapse over time. They are also associated with high production costs...
March 6, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28265888/huntington-disease-linking-pathogenesis-to-the-development-of-experimental-therapeutics
#20
REVIEW
Tiago A Mestre, Cristina Sampaio
Huntington disease (HD) is an autosomal dominant neurodegenerative condition caused by a CAG trinucleotide expansion in the huntingtin gene. At present, the HD field is experiencing exciting times with the assessment for the first time in human subjects of interventions aimed at core disease mechanisms. Out of a portfolio of interventions that claim a potential disease-modifying effect in HD, the target huntingtin has more robust validation. In this review, we discuss the spectrum of huntingtin-lowering therapies that are currently being considered...
February 2017: Current Neurology and Neuroscience Reports
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