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https://www.readbyqxmd.com/read/28432642/emerging-use-of-early-health-technology-assessment-in-medical-product-development-a-scoping-review-of-the-literature
#1
REVIEW
Maarten J IJzerman, Hendrik Koffijberg, Elisabeth Fenwick, Murray Krahn
Early health technology assessment is increasingly being used to support health economic evidence development during early stages of clinical research. Such early models can be used to inform research and development about the design and management of new medical technologies to mitigate the risks, perceived by industry and the public sector, associated with market access and reimbursement. Over the past 25 years it has been suggested that health economic evaluation in the early stages may benefit the development and diffusion of medical products...
April 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28427281/the-servier-oncology-pipeline-in-2017
#2
Patrick Therasse, Beatrice Perron, Sarah A Novack, Jean-Pierre Abastado
Cancer is a complex, multifactorial disease that for years has been the focus of intensive research efforts to explore both the molecular and biological mechanisms involved and the development of novel agents to target these pathways. Servier is an independent French pharmaceutical company with a focus on oncology. Currently, Servier's commercial portfolio includes agents used to treat non-Hodgkin's lymphoma and metastatic colorectal cancer; Servier's oncology pipeline involves agents for the treatment of both solid and hematological tumors...
April 21, 2017: Future Oncology
https://www.readbyqxmd.com/read/28418775/research-101-an-initiative-to-encourage-and-facilitate-quality-resident-research-in-a-military-setting
#3
Kathryn E Marshall, Tanisha L Hammill
Objective Describe and evaluate a structured research program initiated at a tertiary Department of Defense (DOD) Medical Training Facility (MTF) to encourage and facilitate the conduct of research investigations, specifically among residents and junior or inexperienced investigators, but applicable for all DOD otolaryngology (ENT) and audiology providers. Methods A new comprehensive program was deployed in the ENT clinic at Madigan Army Medical Center (MAMC) to help improve the research program. Identified gaps in research methods and regulatory training were incorporated into the existing graduate medical education program along with structured mentorship between residents and senior staff...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28416201/the-impact-of-the-nurse-faculty-scholars-program-on-schools-of-nursing
#4
Angela Barron McBride, Jacquelyn Campbell, Taura Barr, Joanne Duffy, Emily Haozous, Jennifer Mallow, Georgia Narsavage, Nancy Ridenour, Laurie Theeke
BACKGROUND: The Robert Wood Johnson Foundation Nurse Faculty Scholars program was conceptualized as not only promoting the growth and development of early-career faculty but as enhancing the research infrastructure of scholars' schools of nursing. PURPOSE: At the completion of the scholars' three years of support, deans/directors were asked to provide feedback regarding the institutional impact of the scholars' participation in the program. METHODS: Phone interviews were conducted on the first five completed cohorts and a six-item questionnaire was developed to obtain some quantitative data...
March 25, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28413850/scenarios-in-tropical-forest-degradation-carbon-stock-trajectories-for-redd
#5
REVIEW
Rafael B de Andrade, Jennifer K Balch, Amoreena L Parsons, Dolors Armenteras, Rosa Maria Roman-Cuesta, Janette Bulkan
BACKGROUND: Human-caused disturbance to tropical rainforests-such as logging and fire-causes substantial losses of carbon stocks. This is a critical issue to be addressed in the context of policy discussions to implement REDD+. This work reviews current scientific knowledge about the temporal dynamics of degradation-induced carbon emissions to describe common patterns of emissions from logging and fire across tropical forest regions. Using best available information, we: (i) develop short-term emissions factors (per area) for logging and fire degradation scenarios in tropical forests; and (ii) describe the temporal pattern of degradation emissions and recovery trajectory post logging and fire disturbance...
December 2017: Carbon Balance and Management
https://www.readbyqxmd.com/read/28413313/additional-risk-minimisation-measures-for-medicinal-products-in-the-european-union-a-review-of-the-implementation-and-effectiveness-of-measures-in-the-united-kingdom-by-one-marketing-authorisation-holder
#6
Elaine Agyemang, Lorna Bailey, John Talbot
INTRODUCTION: Additional risk minimisation measures (aRMMs) for medicinal products are necessary to address specific important safety issues which may not be practically achieved through routine risk management measures alone. The implementation and determination of effectiveness for aRMMs can be a challenge as it involves multiple stakeholders. It is therefore important to have concise objectives to avoid undue burden on patients, healthcare professionals and the healthcare system. AIM: The aim of this study was to examine how aRMMs are implemented and how effectiveness is assessed in the European Union (EU) using practical examples from Roche Products Limited in the United Kingdom (UK) (referred to as the 'Company')...
2017: Pharmaceutical Medicine
https://www.readbyqxmd.com/read/28407743/new-drugs-new-toxicities-severe-side-effects-of-modern-targeted-and-immunotherapy-of-cancer-and-their-management
#7
REVIEW
Frank Kroschinsky, Friedrich Stölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl, Peter Schellongowski
Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as mild or moderate, but severe and life-threatening complications requiring ICU admission also occur. This review will focus on pathophysiology, symptoms, and management of these events based on the available literature.While standard antineoplastic therapy is associated with immunosuppression and infections, some of the recent approaches induce overwhelming inflammation and autoimmunity...
April 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28403224/hstlbo-a-hybrid-algorithm-based-on-harmony-search-and-teaching-learning-based-optimization-for-complex-high-dimensional-optimization-problems
#8
Shouheng Tuo, Longquan Yong, Fang'an Deng, Yanhai Li, Yong Lin, Qiuju Lu
Harmony Search (HS) and Teaching-Learning-Based Optimization (TLBO) as new swarm intelligent optimization algorithms have received much attention in recent years. Both of them have shown outstanding performance for solving NP-Hard optimization problems. However, they also suffer dramatic performance degradation for some complex high-dimensional optimization problems. Through a lot of experiments, we find that the HS and TLBO have strong complementarity each other. The HS has strong global exploration power but low convergence speed...
2017: PloS One
https://www.readbyqxmd.com/read/28398339/animal-models-to-improve-our-understanding-and-treatment-of-suicidal-behavior
#9
REVIEW
T D Gould, P Georgiou, L A Brenner, L Brundin, A Can, P Courtet, Z R Donaldson, Y Dwivedi, S Guillaume, I I Gottesman, S Kanekar, C A Lowry, P F Renshaw, D Rujescu, E G Smith, G Turecki, P Zanos, C A Zarate, P A Zunszain, T T Postolache
Worldwide, suicide is a leading cause of death. Although a sizable proportion of deaths by suicide may be preventable, it is well documented that despite major governmental and international investments in research, education and clinical practice suicide rates have not diminished and are even increasing among several at-risk populations. Although nonhuman animals do not engage in suicidal behavior amenable to translational studies, we argue that animal model systems are necessary to investigate candidate endophenotypes of suicidal behavior and the neurobiology underlying these endophenotypes...
April 11, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28397339/recent-trends-in-oropharyngeal-cancer-funding-and-public-interest
#10
Michael A Blasco, Peter F Svider, Troy Tenbrunsel, Gautham Vellaichamy, George H Yoo, Andrew M Fribley, S Naweed Raza
OBJECTIVES/HYPOTHESIS: The incidence of oropharyngeal cancer (OPC) has increased in the United States. This has been driven by an increase in human papillomavirus (HPV)-positive OPC. Our objective is to determine trends in National Institutes (NIH)-supported research funding and public interest in OPC. METHODS: The NIH Research Portfolio Online Reporting Tools database was evaluated for projects related to OPC between 2004 and 2015. Projects were evaluated for total funding, relation to HPV, principal investigator departmental affiliation and degree, and NIH agency or center responsible for grant...
April 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28395315/creating-a-future-for-occupational-health
#11
Trevor K Peckham, Marissa G Baker, Janice E Camp, Joel D Kaufman, Noah S Seixas
Objectives: Economic, social, technical, and political drivers are fundamentally changing the nature of work and work environments, with profound implications for the field of occupational health. Nevertheless, researchers and practitioners entering the field are largely being trained to assess and control exposures using approaches developed under old models of work and risks. Methods: A speaker series and symposium were organized to broadly explore current challenges and future directions for the occupational health field...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28395269/strategic-risk-appraisal-comparing-expert-and-literature-informed-consequence-assessments-for-environmental-policy-risks-receiving-national-attention
#12
Jérôme Dagonneau, Sophie A Rocks, George Prpich, Kenisha Garnett, Edgar Black, Simon J T Pollard
Strategic risk appraisal (SRA) has been applied to compare diverse policy level risks to and from the environment in England and Wales. Its application has relied on expert-informed assessments of the potential consequences from residual risks that attract policy attention at the national scale. Here we compare consequence assessments, across environmental, economic and social impact categories that draw on 'expert'- and 'literature-based' analyses of the evidence for 12 public risks appraised by Government...
April 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28384507/european-union-research-in-support-of-environment-and-health-building-scientific-evidence-base-for-policy
#13
REVIEW
Tuomo Karjalainen, Arnd Hoeveler, Ruxandra Draghia-Akli
Opinion polls show that the European Union citizens are increasingly concerned about the impact of environmental factors on their health. In order to respond and provide solid scientific evidence for the numerous policies related to the protection of human health and the environment managed at the Union level, the European Union made a substantial investment in research and innovation in the past two decades through its Framework Programmes for Research and Technological Development, including the current programme, Horizon 2020, which started in 2014...
April 3, 2017: Environment International
https://www.readbyqxmd.com/read/28379081/tensions-in-mentoring-medical-students-toward-self-directed-and-reflective-learning-in-a-longitudinal-portfolio-based-mentoring-system-an-activity-theory-analysis
#14
Sylvia Heeneman, Willem de Grave
BACKGROUND: In medical education, students need to acquire skills to self-direct(ed) learning (SDL), to enable their development into self-directing and reflective professionals. This study addressed the mentor perspective on how processes in the mentor-student interaction influenced development of SDL. METHODS: n = 22 mentors of a graduate-entry medical school with a problem-based curriculum and longitudinal mentoring system were interviewed (n = 1 recording failed)...
April 2017: Medical Teacher
https://www.readbyqxmd.com/read/28371764/new-alternative-energy-pathway-for-chemical-pulp-mills-from-traditional-fibers-to-methane-production
#15
Lourdes Rodriguez-Chiang, Kari Vanhatalo, Jordi Llorca, Olli Dahl
Chemical pulp mills have a need to diversify their end-product portfolio due to the current changing bio-economy. In this study, the methane potential of brown, oxygen delignified and bleached pulp were evaluated in order to assess the potential of converting traditional fibers; as well as microcrystalline cellulose and filtrates; to energy. Results showed that high yields (380mL CH4/gVS) were achieved with bleached fibers which correlates with the lower presence of lignin. Filtrates from the hydrolysis process on the other hand, had the lowest yields (253mL CH4/gVS) due to the high amount of acid and lignin compounds that cause inhibition...
March 25, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28370082/big-data-challenges-of-high-dimensional-continuous-time-mean-variance-portfolio-selection-and-a-remedy
#16
Mei Choi Chiu, Chi Seng Pun, Hoi Ying Wong
Investors interested in the global financial market must analyze financial securities internationally. Making an optimal global investment decision involves processing a huge amount of data for a high-dimensional portfolio. This article investigates the big data challenges of two mean-variance optimal portfolios: continuous-time precommitment and constant-rebalancing strategies. We show that both optimized portfolios implemented with the traditional sample estimates converge to the worst performing portfolio when the portfolio size becomes large...
March 30, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28360337/trainees-in-the-spotlight-yet-another-addition-to-our-portfolio
#17
Roberto Bolli
No abstract text is available yet for this article.
March 31, 2017: Circulation Research
https://www.readbyqxmd.com/read/28351928/ribociclib-lee011-mechanism-of-action-and-clinical-impact-of-this-selective-cyclin-dependent-kinase-4-6-inhibitor-in-various-solid-tumors
#18
Debu Tripathy, Aditya Bardia, William R Sellers
The cyclin D-cyclin-dependent kinase (CDK) 4/6-p16-retinoblastoma (Rb) pathway is commonly disrupted in cancer, leading to abnormal cell proliferation. Therapeutics targeting this pathway have demonstrated antitumor effects in preclinical and clinical studies. Ribociclib is a selective, orally bioavailable inhibitor of CDK4 and CDK6, which was granted priority review by the US Food and Drug Administration in November 2016, and is set to enter the treatment landscape alongside other CDK4/6 inhibitors, including palbociclib and abemaciclib...
March 28, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28351391/the-impact-on-healthcare-policy-and-practice-from-36-multi-project-research-programmes-findings-from-two-reviews
#19
Steve Hanney, Trisha Greenhalgh, Amanda Blatch-Jones, Matthew Glover, James Raftery
BACKGROUND: We sought to analyse the impacts found, and the methods used, in a series of assessments of programmes and portfolios of health research consisting of multiple projects. METHODS: We analysed a sample of 36 impact studies of multi-project research programmes, selected from a wider sample of impact studies included in two narrative systematic reviews published in 2007 and 2016. We included impact studies in which the individual projects in a programme had been assessed for wider impact, especially on policy or practice, and where findings had been described in such a way that allowed them to be collated and compared...
March 28, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28349207/trends-in-national-institutes-of-health-funded-congenital-heart-disease-research-from-2005-to-2015
#20
Kristin M Burns, Victoria L Pemberton, Charlene A Schramm, Gail D Pearson, Jonathan R Kaltman
In an era of ongoing need for research to enable evidence-based care for the expanding population with congenital heart disease (CHD), economic fluctuations have impacted research funding. We characterize trends in NIH-funded CHD research from 2005 to 2015. We searched the NIH RePORTER database from 2005 to 2015 using the terms "congenital heart" and "cardiac morphogenesis". Projects were characterized by year, institute, mechanism, costs, type and topic, and funding trends were analyzed. From 2005 to 2015, NIH funded 633 CHD research projects with total costs of $991 million...
March 27, 2017: Pediatric Cardiology
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