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https://www.readbyqxmd.com/read/29677219/the-association-of-adult-height-with-the-risk-of-cardiovascular-disease-and-cancer-in-the-population-of-sardinia
#1
Giovanni Mario Pes, Antonello Ganau, Eugenia Tognotti, Alessandra Errigo, Chiara Rocchi, Maria Pina Dore
The relationship between body height and the risk of non‒communicable diseases such as cardiovascular disease and cancer has been the subject of much debate in the epidemiological literature. Concerns have recently arisen over spurious associations due to confounding factors like birth cohort, especially in the context of epidemiological transition. The population of Sardinia represents an interesting case study, as the average physical stature of inhabitants was the lowest recorded in Europe until a few decades ago...
2018: PloS One
https://www.readbyqxmd.com/read/29677139/musculoskeletal-model-development-of-the-elbow-joint-with-an-experimental-evaluation
#2
Munsur Rahman, Mohsen Sharifi Renani, Akin Cil, Antonis P Stylianou
A dynamic musculoskeletal model of the elbow joint in which muscle, ligament, and articular surface contact forces are predicted concurrently would be an ideal tool for patient-specific preoperative planning, computer-aided surgery, and rehabilitation. Existing musculoskeletal elbow joint models have limited clinical applicability because of idealizing the elbow as a mechanical hinge joint or ignoring important soft tissue (e.g., cartilage) contributions. The purpose of this study was to develop a subject-specific anatomically correct musculoskeletal elbow joint model and evaluate it based on experimental kinematics and muscle electromyography measurements...
April 20, 2018: Bioengineering
https://www.readbyqxmd.com/read/29676938/the-development-of-a-biotinylated-nad-applied-human-poly-adp-ribose-polymerase-3-parp3-enzymatic-assay
#3
Ming Ji, Liyuan Wang, Nina Xue, Fangfang Lai, Sen Zhang, Jing Jin, Xiaoguang Chen
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. The biological roles of PARP3 are currently under investigation; however, several key reports indicate the integral roles of PARP3 in DNA damage repair, and thus it has been investigated as a novel target in oncology. It is clear that the identification of selective PARP3 inhibitors would further advance the understanding of the biological roles of PARP3. Herein, we describe a modified PARP3 screening assay using biotinylated NAD+ as the specialized substrate...
April 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29676651/immunohistochemical-localization-of-fam83h-during-fluorosis-induced-mouse-molar-development
#4
Guanghui Shi, Yanyan Zhou, Jing Guo, Zhongrui Yang, Yang Lu, Yaling Song, Jie Jia
The clinical and pathological features of fluorosis are similar to amelogenesis imperfecta (AI) caused by FAM83H mutations, suggesting that excess fluoride could have effects on the expression of Fam83h. Our previous study found that Fam83h was downregulated by fluorosis induction in ameloblasts; the purpose of this study was to underline the importance of understanding the relationship between fluoride administration and Fam83h expression in vivo. A total of 80 healthy female adult Kunming mice were randomly divided into control group or F group that induced the clinical features of fluorosis...
April 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29676558/utilizing-intramolecular-photoinduced-electron-transfer-to-enhance-photothermal-tumor-treatment-of-aza-bodipy-based-nir-nanoparticles
#5
Yunjian Xu, Teng Feng, Tianshe Yang, Huanjie Wei, Huiran Yang, Guo Li, Menglong Zhao, Shujuan Liu, Wei Huang, Qiang Zhao
Photothermal therapy (PTT) as a kind of noninvasive tumor treatment has attracted increasing research interest. However, the efficiency of existing PTT agents in the near-infrared (NIR) region is the major problem that has hindered further development of PTT. Herein, we present an effective strategy to construct the efficient photothermal agent by utilizing an intramolecular photoinduced electron transfer (PeT) mechanism, which is able to dramatically improve photothermal conversion efficiency in NIR region...
April 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29676497/longevity-of-ceramic-onlays-a-systematic-review
#6
REVIEW
Jaafar Abduo, Raelene Jo Sambrook
OBJECTIVE: This systematic review aimed to evaluate the longevity of ceramic onlays and identify the factors that influence their survival. MATERIALS AND METHODS: An electronic search was conducted through PubMed (MEDLINE), Google Scholar and Cochrane Library, up to August 2017. The literature search aimed to retrieve all the clinical studies on the longevity of ceramic onlays. Ceramic onlay was defined as any partial ceramic restoration that covers at least one cusp...
April 20, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29676142/-analysis-of-acne-animal-model-based-on-chinese-and-western-medicine-clinical-symptoms-characteristic
#7
Zhen-Na Fu, Ting Wang, Ming Bai, Ming-San Miao
This paper aimed to analyze the existing acne animal model based on the characteristics of acne clinical symptoms between Chinese and western medicine, in order to provide reference for the establishment of the rational acne animal model. Relevant literatures at home and abroad in recent years were reviewed to summarize the research progress of diagnostic criteria and drug treatment of acne with Chinese and western medicine, and analyze the existing acne animal model. The animal acne models were pathological models, and mainly reflected the clinical indicators of western medicine...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675509/giant-cells-osseous-tumor-in-the-tarsal-canal-after-lateral-ankle-sprain
#8
Marcello Lughi
Ankle sprain can cause injuries to the anatomic structures surrounding the tibiotarsal joint. A possible extra-articular pathology is to be hypothesized and diagnosed as early as possible. The subtalar joint, for anatomical and functional reasons, is one of the most damaged joints following an ankle sprain. In spite of this, its involvement is often underestimated. The clinical case presented in the present article is referred to a giant cells osseous tumor in the tarsal canal that was diagnosed 2 months after an inversion ankle sprain...
March 2018: Joints
https://www.readbyqxmd.com/read/29675348/clinical-histopathology-of-intrachoroidal-splitting-in-open-globe-injury-a-retrospective-case-series-of-four-patients
#9
Liang Han, Yen-Ling Cho, Zhizhong Ma, Xinrong Zhao, Xin Chang
PURPOSE: The purpose of this study is to observe the characteristics of intrachoroidal splitting (ICS) associated with choroidal detachment due to open-globe injury. METHODS: A retrospective, observational case series study of four eyes diagnosed with choroidal detachment exhibited ICS. The in vivo pathologic changes of the ICS were recorded during surgery. Four specimens were obtained from the inner part of the ICS region. One specimen was stained with hematoxylin and eosin; one specimen was examined under scanning electron microscopy, and the other two specimens were examined under transmission electron microscopy...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675062/indications-retrieval-rate-and-complications-of-inferior-vena-cava-filters-single-center-experience-in-saudi-arabia
#10
Abdullah Bin Shabib, Fahad Alsayed, Saad Aldughaythir, Hanan Habeeb, Sumayyah Al Tamimi, Emad Masuadi, Mohsen Alzahrani, Ali Alaklabi, Azzam Alotaibi, Rajkumar Rajendram, Mosaad Almegren
BACKGROUND: Inferior vena cava (IVC) filter is indicated in patients with acute venous thromboembolism (VTE) in whom therapeutic anticoagulation is contraindicated. While prophylactic insertion of an IVC filter may be considered for patients at high risk of VTE, there are significant differences between clinical guidelines on the role of IVC filters. These discrepancies have arisen predominantly because of the paucity of data on the efficacy and safety of IVC filters. We, therefore, evaluated the indications for filter insertion, the rate of filter retrieval and complications in patients who received IVC filters at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia...
April 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29674250/aspects-of-alcohol-use-disorder-affecting-social-cognition-as-assessed-using-the-mini-social-and-emotional-assessment-mini-sea
#11
Sharon Cox, Maxime Bertoux, John J D Turner, Antony Moss, Kirsty Locker, Kevin Riggs
BACKGROUND: Alcohol Use Disorder (AUD) is associated with problems with processing complex social scenarios. Little is known about the relationship between distinct AUD-related factors (e.g., years of problematic drinking), aspects of cognitive function and dysfunction in individuals diagnosed with AUD, and the relative impact these may have on social cognition. AIMS: To explore differences in social cognition between a group of participants diagnosed with AUD and controls, using a clinical measure, the Mini Social and Emotional Assessment (mini-SEA)...
April 10, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29673723/marijuana-use-by-adolescents-and-young-adults-with-inflammatory-bowel-disease
#12
Edward J Hoffenberg, Shannon K McWilliams, Susan K Mikulich-Gilbertson, Brittany V Murphy, Megan Lagueux, Kristen Robbins, Analice S Hoffenberg, Edwin de Zoeten, Christian J Hopfer
OBJECTIVE: To evaluate marijuana use by adolescents and young adults with inflammatory bowel disease (IBD). STUDY DESIGN: This descriptive cross-sectional study of patients seen between December 2015 through June 2017 at Children's Hospital Colorado for IBD enrolled patients 13-23 years of age, independent of marijuana use status. Information obtained consisted of chart review, electronic and interview self-report, and serum cannabinoid levels. Marijuana ever-users were compared with never-users for clinical characteristics and perceptions of risk with use; users provided information on routes, patterns, motivations, and perceived benefits and problems with use...
April 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29673616/nxy-059-a-failed-stroke-neuroprotectant-offers-no-protection-to-stem-cell-derived-human-neurons
#13
Ana Antonic, Mirella Dottori, Malcolm R Macleod, Geoffrey A Donnan, David W Howells
BACKGROUND: Developing new medicines is a complex process where understanding the reasons for both failure and success takes us forward. One gap in our understanding of most candidate stroke drugs before clinical trial is whether they have a protective effect on human tissues. NXY-059 is a spin-trap reagent hypothesized to have activity against the damaging oxidative biology which accompanies ischemic stroke. Re-examination of the preclinical in vivo dataset for this agent in the wake of the failed SAINT-II RCT highlighted the presence of a range of biases leading to overestimation of the magnitude of NXY-059's effects in laboratory animals...
April 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29673601/decision-support-system-for-triage-management-a-hybrid-approach-using-rule-based-reasoning-and-fuzzy-logic
#14
Mahsa Dehghani Soufi, Taha Samad-Soltani, Samad Shams Vahdati, Peyman Rezaei-Hachesu
OBJECTIVES: Fast and accurate patient triage for the response process is a critical first step in emergency situations. This process is often performed using a paper-based mode, which intensifies workload and difficulty, wastes time, and is at risk of human errors. This study aims to design and evaluate a decision support system (DSS) to determine the triage level. METHODS: A combination of the Rule-Based Reasoning (RBR) and Fuzzy Logic Classifier (FLC) approaches were used to predict the triage level of patients according to the triage specialist's opinions and Emergency Severity Index (ESI) guidelines...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29673363/efficacy-of-live-attenuated-porcine-reproductive-and-respiratory-syndrome-virus-2-strains-to-protect-pigs-from-challenge-with-a-heterologous-vietnamese-prrsv-2-field-strain
#15
Tatjana Sattler, Jutta Pikalo, Eveline Wodak, Sandra Revilla-Fernández, Adi Steinrigl, Zoltán Bagó, Ferdinand Entenfellner, Jean-Baptiste Claude, Floriane Pez, Maela Francillette, Friedrich Schmoll
BACKGROUND: Effective vaccines against porcine reproductive and respiratory syndrome virus (PRRSV), especially against highly pathogenic (HP) PRRSV are still missing. The objective of this study was to evaluate the protective efficacy of an experimental live attenuated PRRSV 2 vaccine, composed of two strains, against heterologous challenge with a Vietnamese HP PRRSV 2 field strain. For this reason, 20 PRRSV negative piglets were divided into two groups. The pigs of group 1 were vaccinated with the experimental vaccine, group 2 remained unvaccinated...
April 19, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29673278/doing-what-s-right-a-grounded-theory-of-ethical-decision-making-in-occupational-therapy
#16
Sandra VanderKaay, Lori Letts, Bonny Jung, Sandra E Moll
BACKGROUND: Ethical decision-making is an important aspect of reasoning in occupational therapy practice. However, the process of ethical decision-making within the broader context of reasoning is yet to be clearly explicated. OBJECTIVE: The purpose of this study was to advance a theoretical understanding of the process by which occupational therapists make ethical decisions in day-to-day practice. METHOD: A constructivist grounded theory approach was adopted, incorporating in-depth semi-structured interviews with 18 occupational therapists from a range of practice settings and years of experience...
April 20, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29673263/why-are-copd-patients-unable-to-complete-the-outpatient-pulmonary-rehabilitation-program
#17
Hulya Sahin, Ilknur Naz
This study aims to compare demographic and clinical characteristics of chronic obstructive pulmonary disease (COPD) patients who complete and fail to complete outpatient pulmonary rehabilitation (PR) program and to determine the reasons for not completing the program. Patients with COPD referred to the PR program were divided into two groups: Those who completed the program were classified as group 1 and those who did not complete were classified as group 2, and their data were compared. Patients who failed to complete the program were contacted through phone and asked why they ceased their participation in the program...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29673069/short-term-memory-impairment-in-vestibular-patients-can-arise-independently-of-psychiatric-impairment-fatigue-and-sleeplessness
#18
Laura Smith, David Wilkinson, Mayur Bodani, Rowena Bicknell, S S Surenthiran
Vestibular dysfunction is associated with visual short-term memory impairment; however, it remains unclear if this impairment arises as a direct result of the vestibular dysfunction or is a consequence of comorbid changes in mood, affect, fatigue, and/or sleep. To this end, we assessed the concurrence and interdependence of these comorbidities in 101 individuals recruited from a tertiary balance clinic with a neuro-otological diagnosis. Over fifty per cent of the sample showed reduced visuospatial short-term memory, 60% and 37% exceeded cut-off on the Beck Anxiety and Depression Inventories, respectively, 70% exceeded cut-off on the Fatigue Severity Scale, 44% reported daytime sleepiness on the Epworth Sleepiness Scale, and 78% scored above cut-off on the Pittsburgh Sleep Quality Index...
April 19, 2018: Journal of Neuropsychology
https://www.readbyqxmd.com/read/29672463/limited-additional-value-of-cervical-ultrasonography-over-a-negative-18f-fdg-pet-ct-for-diagnosing-cervical-lymph-node-metastases-in-patients-with-esophageal-cancer-a-systematic-review-and-meta-analysis
#19
Lucas Goense, Jihane Meziani, Peter S N van Rossum, Frank J Wessels, Gert J Meijer, Marnix G E H Lam, Richard van Hillegersberg, Jelle P Ruurda
OBJECTIVE: To assess the additional value of cervical ultrasonography as supplement to a negative fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) for detecting cervical lymph node metastases during the initial staging of patients with esophageal cancer. METHODS: PubMed/Medline, Embase, and the Cochrane library were systematically searched. The analysis included diagnostic studies describing the accuracy of cervical ultrasonography and integrated F-FDG PET/CT or standalone F-FDG PET and CT for detecting cervical lymph node metastases in patients with esophageal cancer...
April 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29672438/alterations-of-inflammatory-and-matrix-production-indices-in-celiac-disease-with-low-bone-mass-on-long-term-gluten-free-diet
#20
Michele Di Stefano, Manuela Bergonzi, Irene Benedetti, Mara De Amici, Cristina Torre, Natascia Brondino, Emanuela Miceli, Elisabetta Pagani, Gian L Marseglia, Gino R Corazza, Antonio Di Sabatino
BACKGROUND: A clinically meaningful impairment of bone mass secondary to malabsorption is frequent in untreated celiac disease. In adult patients, a rigorous gluten-free diet (GFD) significantly improves, but does not always normalize, bone mineral density (BMD). The reason for this marginal response is unclear. Accordingly, we evaluated the role of both local and systemic factors for bone loss in celiac patients on long-term GFD. STUDY: In a prospective cohort, 22 patients with low lumbar and/or femoral BMD and 22 with normal BMD underwent bone and mineral metabolism evaluation: we tested calcium, phosphate, parathyroid hormone, and vitamin D; telopeptide of type I collagen, a bone resorption index; propeptide of type I procollagen, a bone neoformation index; receptor antagonist of NF-kB ligand, an osteoclast-stimulating factor; osteoprotegerin (OPG), a decoy receptor for RANKL...
April 18, 2018: Journal of Clinical Gastroenterology
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