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https://www.readbyqxmd.com/read/29933405/influence-of-cast-change-interval-in-the-ponseti-method-a-systematic-review
#1
R B Giesberts, M C van der Steen, P G M Maathuis, A T Besselaar, E E G Hekman, G J Verkerke
BACKGROUND: Clubfeet are commonly treated using the Ponseti method. This method involves weekly manipulation and casting which gradually corrects the position of the foot. However, the reasons for following a weekly interval are not clear. QUESTION / PURPOSE: The aim is to investigate the influence of the cast change interval on treatment outcomes in the Ponseti method. METHODS: We performed a systematic review of comparative studies in which the cast change interval was varied...
2018: PloS One
https://www.readbyqxmd.com/read/29933291/vestibular-sclerosis-is-this-a-new-distinct-clinicopathological-entity
#2
Bethany A Croker, James P Scurry, Frances M Petry, Gayle Fischer
OBJECTIVES: The aims of this case series were to present a series of patients with clinical and histopathological findings consistent with a recently described condition vestibular sclerosis (VS) and to contribute to the current discussion of whether VS is a subset of lichen sclerosus (LS) or a distinct entity. MATERIALS AND METHODS: This case series of 6 women for a 12-month period was initiated from an ongoing collaboration between a gynecological dermatologist and an anatomical pathologist specializing in gynecological dermatopathology...
July 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29933123/the-effect-of-upper-instrumented-vertebra-level-on-cervical-sagittal-alignment-in-lenke-1-adolescent-idiopathic-scoliosis
#3
Ismail Emre Ketenci, Hakan Serhat Yanik, Sevki Erdem
BACKGROUND: This study aimed to evaluate the relationship between upper instrumented vertebra (UIV) level and cervical sagittal alignment (CSA) in Lenke 1 adolescent idiopathic scoliosis (AIS) patients, treated with posterior instrumentation. The hypothesis was that higher level of UIV would cause decreased cervical lordosis. METHODS: 63 Lenke 1 AIS patients that underwent posterior fusion with pedicle screw instrumentation were retrospectively evaluated. Patients were divided into three groups according to UIV level (T2, T3, T4)...
June 19, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29933071/autologous-stem-cell-transplant-for-al-amyloidosis-patients-aged-70-to-75
#4
M Hasib Sidiqi, Mohammed A Aljama, Eli Muchtar, Francis K Buadi, Rahma Warsame, Martha Q Lacy, Angela Dispenzieri, David Dingli, Nelson Leung, Wilson I Gonsalves, Prashant Kapoor, Taxiarchis V Kourelis, William J Hogan, Shaji K Kumar, Morie A Gertz
Autologous stem cell transplantation has been used in treatment for AL amyloidosis for over two decades and generally reserved for patients younger than 70 years of age. Herein we report on outcomes of ASCT in a cohort of patients with AL amyloidosis aged 70 years or older. Between August of 2002 and April of 2017, 34 patients aged 70 years or older, with biopsy proven AL amyloidosis, received an autologous stem cell transplant at the Mayo Clinic Rochester. 70% (n=24) of patients were transplanted within 6 months of diagnosis and 74% (n=25) received reduced intensity conditioning with melphalan <200mg/m2...
June 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29933003/contemporary-teaching-of-restoration-repair-at-dental-schools-in-germany-close-to-universality-and-consistency
#5
Philipp Kanzow, Annette Wiegand, Nairn H F Wilson, Christopher D Lynch, Igor R Blum
OBJECTIVES: To identify potential changes in various aspects of teaching and to ascertain whether previously found inconsistencies in the teaching of criteria, indications and operative techniques for the repair of defective composite restorations at German dental schools have been resolved. METHODS: A validated questionnaire was used to gain the information sought. It was sent to all dental schools in Germany (n = 30). Whenever possible, data were compared to previous studies conducted in 2000 and 2009...
June 19, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29932038/community-acquired-pneumonia-in-children
#6
Alexander Kc Leung, Alex H C Wong, Kam Lun Hon
BACKGROUND: Community-acquired pneumonia is an important cause of morbidity in developed countries and an important cause of morbidity and mortality in developing countries. Prompt diagnosis and appropriate treatment are very important. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of community-acquired pneumonia in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "community-acquired pneumonia"...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29931752/tackling-clinical-inertia-the-use-of-co-production-to-improve-patient-engagement
#7
REVIEW
Carmen Soto, William David Strain
Clinical inertia is common in all chronic diseases including diabetes. Despite the advent of newer agents for the management of hyperglycaemia, hypertension and dyslipidaemia, the number of people with diabetes hitting all three targets remains small. The causes of clinical inertia are multifactorial, with contributory elements from people with diabetes, physicians, and the system within which they work. Every healthcare provider should havethe best interest of their patients at heart;most people with diabetes want to maintain their health for as long as possible; and the maintenance of good health is not only the purpose of the system, but also the most cost-effective strategy...
June 22, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29931734/evaluation-of-corneal-and-lens-clarity-in-unilateral-pseudoexfoliation-syndrome-a-densitometric-analysis
#8
Irfan Durukan
BACKGROUND: Although ageing is the main reason for cataract progression, pseudoexfoliation syndrome (PES) represents an independent additional hazard for the development of nuclear sclerosis and cataract progression. PES can also affect corneal properties. From this perspective, this study aimed to perform a comparison of the corneal and lens densitometry measurements in eyes with PES and age-matched healthy eyes. METHODS: This prospective cross-sectional study included 31 patients with unilateral PES and 40 control participants...
June 21, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29931515/chronic-obstructive-pulmonary-disease-may-complicate-alzheimer-s-disease-a-comorbidity-problem
#9
Giacomo Tondo, Fabiola De Marchi, Emanuela Terazzi, Paolo Prandi, Marta Sacchetti, Cristoforo Comi, Roberto Cantello
BACKGROUND AND AIM: Chronic obstructive pulmonary disease (COPD) may be associated with worsening of cognitive performance. We studied patients with Alzheimer's disease (AD) with and without COPD, and we analyzed, in a retrospective way, clinical and neuropsychological variables to verify if COPD plays a pejorative role on cognitive or functional autonomy in patients with dementia. METHODS: We enrolled 23 adult patients (AD-COPD) with probable AD and COPD and 23 with AD only (AD-only); they were matched for sex, age, educational level, and Mini Mental State Examination (MMSE) at the disease onset...
June 21, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29931473/lung-ultrasound-in-diagnosing-pneumonia-in-childhood-a-systematic-review-and-meta-analysis
#10
REVIEW
Daniele Orso, Alessio Ban, Nicola Guglielmo
PURPOSE: Pneumonia is the third leading cause of death in children under 5 years of age worldwide. In pediatrics, both the accuracy and safety of diagnostic tools are important. Lung ultrasound (LUS) could be a safe diagnostic tool for this reason. We searched in the literature for diagnostic studies about LUS to predict pneumonia in pediatric patients using systematic review and meta-analysis. METHODS: The Medline, CINAHL, Cochrane Library, Embase, SPORTDiscus, ScienceDirect, and Web of Science databases from inception to September 2017 were searched...
June 21, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29931376/medication-compliance-in-singaporean-patients-with-alzheimer-s-disease
#11
Zheng Kang Lum, Ma Serrie P Suministrado, N Venketasubramanian, M Kamran Ikram, Christopher Chen
INTRODUCTION: Singapore has a rapidly ageing population and an increasing prevalence of Alzheimer's disease (AD). Compliance to AD medications is associated with treatment effectiveness. We investigated compliance to acetylcholinesterase inhibitors (AChEIs) and N-methyl-D-aspartate (NMDA) receptor antagonist and treatment persistence among patients seen at the General Memory Clinic of National University Hospital, Singapore. We also identified the reasons for non-compliance. METHODS: Patients seen at the General Memory Clinic between 1 January 2013 and 31 December 2014, who were prescribed AChEIs and NMDA receptor antagonist, were included in this retrospective cohort study...
June 22, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29931270/gluteal-augmentation-with-fat-retrospective-safety-study-and-literature-review
#12
Amin Kalaaji, Stine Dreyer, Line Vadseth, Ivana Maric, Vanja Jönsson, Trond H Haukebøe
Background: Use of gluteal augmentation with fat increased by 3267% from 2002 to 2015, and the rate of death is highest compared with other aesthetic procedures: 1 in 3448 patients dies, compared with 1 in 55,000. Objectives: To retrospectively investigate patients who underwent this procedure at Oslo Plastic Surgery Clinic, to review international data determine factors causing mortality, and to provide guidelines for safety. Methods: Patient data were searched for reason for the procedure, assessment of patients, techniques performed, and safety measures used...
June 20, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29931037/factor-structure-of-the-wechsler-intelligence-scale-for-children-fourth-edition-spanish-in-a-clinical-sample
#13
Alicia Nuñez, Davor N Zink, Kimberly A Barchard, Liza E San Miguel, Daniel N Allen
Objective: The Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish) is a translation and adaptation of the WISC-IV that is often used in neuropsychological evaluation of children and adolescents with acquired or developmental brain disorders. However, there is limited information on the factor structure of the WISC-IV Spanish when used with clinical populations. To address the potential effects of language and culture on the validity of the WISC-IV Spanish factor structure, this study examined the construct validity of the WISV-IV Spanish scores using confirmatory factor analysis in a clinical sample of Hispanic children with Attention-Deficit/Hyperactivity Disorder (ADHD)...
June 21, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29930727/a-tightly-controlled-src-yap-signaling-axis-determines-therapeutic-response-to-dasatinib-in-renal-cell-carcinoma
#14
Jingya Sun, Xin Wang, Boyun Tang, Hongchun Liu, Minmin Zhang, Yueqin Wang, Fangfang Ping, Jian Ding, Aijun Shen, Meiyu Geng
Over the past decade, therapies targeting the VEGF/VEGFR and mTOR pathways have served as the standard of care for the clinical management of renal cell carcinoma (RCC) patients. Albeit promising, these targeted drugs have attained only modest clinical benefits with limited prolonged progression-free survival. Therefore, alternative reasonable and applicable therapeutic approaches should be introduced to improve the clinical outcome of RCC patients. Methods: FDA approved kinase inhibitors were screened to evaluate their abilities to suppress the proliferation of RCC cells...
2018: Theranostics
https://www.readbyqxmd.com/read/29930483/sublingual-grass-allergen-specific-immunotherapy-a-retrospective-study-of-clinical-outcome-and-discontinuation
#15
Christer Janson, Fredrik Sundbom, Peter Arvidsson, Mary Kämpe
Background: Sublingual immunotherapy (SLIT) is effective, tolerable, and convenient for many allergic patients. Still, real-world evidence is scarce and the aim of this study is to assess the patient reported outcome of treatment with SLIT against grass pollen allergy in a consecutive patient population. Methods: Patients (n = 329) who were confirmed to be allergic to timothy grass and had been prescribed SLIT were consecutively enrolled in the study and completed a questionnaire online or in hard copy...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29930368/the-longevity-of-posterior-restorations-in-primary-teeth
#16
Sherry Shiqian Gao
Data sourcesSciVerse Scopus, ISIS Web of Science, Cochrane library, Medline/PubMed. Studies published from 1996 to 2017 in English were considered.Study selectionTwo independent reviewers screened the literature. Randomised clinical trials, non-randomised clinical trials with parallel groups or single group, retrospective studies) evaluating different posterior restorations (class I, class II restorations and crowns) with different materials (amalgam, compomer, composite, glass ionomer cement, stainless steel crown) placed in primary teeth by reporting different outcomes measures (survival rate, success rate, annual failure rate)...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29929818/progress-in-knee-arthroscopy-skills-of-residents-and-medical-students-a-prospective-assessment-of-simulator-exercises-and-analysis-of-learning-curves
#17
Dietmar Dammerer, David Putzer, Alexander Wurm, Michael Liebensteiner, Michael Nogler, Martin Krismer
OBJECTIVE: Knee arthroscopies are very common orthopedic procedures. For a number of reasons, including increased public awareness for medical errors, patient safety, strict regulations governing duty-hours for residents, surgeons' liability, and an increasing emphasis on the efficient use of operating room time, interest in simulator training is on the rise. It was the purpose of this study to analyze learning curves of medical students and orthopedic resident surgeons using a virtual knee arthroscopy simulator...
June 18, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29929641/outcomes-following-urgent-emergent-transcatheter-aortic-valve-replacement-insights-from-the-sts-acc-tvt-registry
#18
Dhaval Kolte, Sahil Khera, Sreekanth Vemulapalli, Dadi Dai, Stephan Heo, Andrew M Goldsweig, Herbert D Aronow, Sammy Elmariah, Ignacio Inglessis, Igor F Palacios, Vinod H Thourani, Barry L Sharaf, Paul C Gordon, J Dawn Abbott
OBJECTIVES: The authors sought to examine outcomes and identify independent predictors of mortality among patients undergoing urgent/emergent transcatheter aortic valve replacement (TAVR). BACKGROUND: Data on urgent/emergent TAVR as a rescue therapy for decompensated severe aortic stenosis (AS) are limited. METHODS: The Society of Thoracic Surgeons and the American College of Cardiology Transcatheter Valve Therapy (STS/ACC TVT) Registry linked with Centers for Medicare & Medicaid Services claims was used to identify patients who underwent urgent/emergent versus elective TAVR between November 2011 and June 2016...
June 25, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29929212/pharmacological-therapies-for-management-of-opium-withdrawal
#19
REVIEW
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29928325/hoxb13-expression-and-promoter-methylation-as-a-candidate-biomarker-in-gastric-cancer
#20
Bai-Qiang Sui, Chun-Dong Zhang, Ji-Chao Liu, Lei Wang, Dong-Qiu Dai
Homeobox b13 (HOXB13) is considered to be a tumor suppressor gene in multiple types of human cancer. The present study aimed to identify the difference in expression of HOXB13 mRNA between gastric cancer (GC) tissues and corresponding non-malignant gastric tissues. The clinical significance of HOXB13 mRNA expression was also assessed in GC and a potential association between HOXB13 mRNA expression and DNA promoter methylation was observed. The expression of HOXB13 mRNA was assessed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and HOXB13 methylation status was assessed by methylation-specific PCR (MSP) in 5 GC cell lines and 85 paired GC and normal gastric tissues...
June 2018: Oncology Letters
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